Alan S Perelson - Publications

Affiliations: 
Theoretical Division Los Alamos National Laboratory, Los Alamos, NM, United States 

272 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2024 Phan T, Ribeiro RM, Edelstein GE, Boucau J, Uddin R, Marino C, Liew MY, Barry M, Choudhary MC, Tien D, Su K, Reynolds Z, Li Y, Sagar S, Vyas TD, ... ... Perelson AS, et al. Modeling suggests SARS-CoV-2 rebound after nirmatrelvir-ritonavir treatment is driven by target cell preservation coupled with incomplete viral clearance. Biorxiv : the Preprint Server For Biology. PMID 39345409 DOI: 10.1101/2024.09.13.613000  0.643
2024 Phan T, Conway JM, Pagane N, Kreig J, Sambaturu N, Iyaniwura S, Li JZ, Ribeiro RM, Ke R, Perelson AS. Understanding early HIV-1 rebound dynamics following antiretroviral therapy interruption: The importance of effector cell expansion. Plos Pathogens. 20: e1012236. PMID 39074163 DOI: 10.1371/journal.ppat.1012236  0.631
2024 Iyaniwura SA, Cassidy T, Ribeiro RM, Perelson AS. A multiscale model of the action of a capsid assembly modulator for the treatment of chronic hepatitis B. Biorxiv : the Preprint Server For Biology. PMID 39071423 DOI: 10.1101/2024.07.16.603658  0.62
2024 Phan T, Conway JM, Pagane N, Kreig J, Sambaturu N, Iyaniwura S, Li JZ, Ribeiro RM, Ke R, Perelson AS. Understanding early HIV-1 rebound dynamics following antiretroviral therapy interruption: The importance of effector cell expansion. Biorxiv : the Preprint Server For Biology. PMID 38746144 DOI: 10.1101/2024.05.03.592318  0.631
2024 Phan T, Zitzmann C, Chew KW, Smith DM, Daar ES, Wohl DA, Eron JJ, Currier JS, Hughes MD, Choudhary MC, Deo R, Li JZ, Ribeiro RM, Ke R, Perelson AS. Modeling the emergence of viral resistance for SARS-CoV-2 during treatment with an anti-spike monoclonal antibody. Plos Pathogens. 20: e1011680. PMID 38635853 DOI: 10.1371/journal.ppat.1011680  0.625
2024 Zitzmann C, Ke R, Ribeiro RM, Perelson AS. How robust are estimates of key parameters in standard viral dynamic models? Plos Computational Biology. 20: e1011437. PMID 38626190 DOI: 10.1371/journal.pcbi.1011437  0.637
2024 Kitagawa K, Kim KS, Iwamoto M, Hayashi S, Park H, Nishiyama T, Nakamura N, Fujita Y, Nakaoka S, Aihara K, Perelson AS, Allweiss L, Dandri M, Watashi K, Tanaka Y, et al. Multiscale modeling of HBV infection integrating intra- and intercellular viral propagation to analyze extracellular viral markers. Plos Computational Biology. 20: e1011238. PMID 38466770 DOI: 10.1371/journal.pcbi.1011238  0.389
2024 Lim SY, Lee J, Osuna CE, Vikhe P, Schalk DR, Chen E, Fray E, Kumar M, Schultz-Darken N, Rakasz E, Capuano S, Ladd RA, Gil HM, Evans DT, Jeng EK, ... ... Perelson AS, et al. Induction of durable remission by dual immunotherapy in SHIV-infected ART-suppressed macaques. Science (New York, N.Y.). eadf7966. PMID 38422185 DOI: 10.1126/science.adf7966  0.412
2024 Williams B, Carruthers J, Gillard JJ, Lythe G, Perelson AS, Ribeiro RM, Molina-París C, López-García M. The reproduction number and its probability distribution for stochastic viral dynamics. Journal of the Royal Society, Interface. 21: 20230400. PMID 38264928 DOI: 10.1098/rsif.2023.0400  0.619
2023 Sambaturu N, Fray EJ, Wu F, Zitzmann C, Simonetti FR, Barouch DH, Siliciano JD, Siliciano RF, Ribeiro RM, Perelson AS, Molina-París C, Leitner T. Last in first out: SIV proviruses seeded later in infection are harbored in short-lived CD4 T cells. Biorxiv : the Preprint Server For Biology. PMID 37961482 DOI: 10.1101/2023.11.03.565539  0.663
2023 Policicchio BB, Cardozo-Ojeda EF, Xu C, Ma D, He T, Raehtz KD, Sivanandham R, Kleinman AJ, Perelson AS, Apetrei C, Pandrea I, Ribeiro RM. CD8 T cells control SIV infection using both cytolytic effects and non-cytolytic suppression of virus production. Nature Communications. 14: 6657. PMID 37863982 DOI: 10.1038/s41467-023-42435-8  0.647
2023 Kumar MR, Fray EJ, Bender AM, Zitzmann C, Ribeiro RM, Perelson AS, Barouch DH, Siliciano JD, Siliciano RF. Biphasic decay of intact SHIV genomes following initiation of antiretroviral therapy complicates analysis of interventions targeting the reservoir. Proceedings of the National Academy of Sciences of the United States of America. 120: e2313209120. PMID 37844236 DOI: 10.1073/pnas.2313209120  0.601
2023 Dashti A, Sukkestad S, Horner AM, Neja M, Siddiqi Z, Waller C, Goldy J, Monroe D, Lin A, Schoof N, Singh V, Mavigner M, Lifson JD, Deleage C, Tuyishime M, ... ... Perelson AS, et al. AZD5582 plus SIV-specific antibodies reduce lymph node viral reservoirs in antiretroviral therapy-suppressed macaques. Nature Medicine. 29: 2535-2546. PMID 37783968 DOI: 10.1038/s41591-023-02570-7  0.343
2023 Phan T, Zitzmann C, Chew KW, Smith DM, Daar ES, Wohl DA, Eron JJ, Currier JS, Hughes MD, Choudhary MC, Deo R, Li JZ, Ribeiro RM, Ke R, Perelson AS. Modeling the emergence of viral resistance for SARS-CoV-2 during treatment with an anti-spike monoclonal antibody. Biorxiv : the Preprint Server For Biology. PMID 37745410 DOI: 10.1101/2023.09.14.557679  0.627
2023 Ribeiro RM, Choudhary MC, Deo R, Giganti MJ, Moser C, Ritz J, Greninger AL, Regan J, Flynn JP, Wohl DA, Currier JS, Eron JJ, Hughes MD, Smith DM, Chew KW, ... ... Perelson AS, et al. Variant-Specific Viral Kinetics in Acute COVID-19. The Journal of Infectious Diseases. 228: S136-S143. PMID 37650233 DOI: 10.1093/infdis/jiad314  0.588
2023 Phan T, Brozak S, Pell B, Oghuan J, Gitter A, Hu T, Ribeiro RM, Ke R, Mena KD, Perelson AS, Kuang Y, Wu F. Making waves: Integrating wastewater surveillance with dynamic modeling to track and predict viral outbreaks. Water Research. 243: 120372. PMID 37494742 DOI: 10.1016/j.watres.2023.120372  0.522
2023 McMyn NF, Varriale J, Fray EJ, Zitzmann C, MacLeod HJ, Lai J, Singhal A, Moskovljevic M, Garcia MA, Lopez BM, Hariharan V, Rhodehouse K, Lynn K, Tebas P, Mounzer K, ... ... Perelson AS, et al. The latent reservoir of inducible, infectious HIV-1 does not decrease despite decades of antiretroviral therapy. The Journal of Clinical Investigation. PMID 37463049 DOI: 10.1172/JCI171554  0.572
2023 Perelson AS, Ribeiro RM, Phan T. An explanation for SARS-CoV-2 rebound after Paxlovid treatment. Medrxiv : the Preprint Server For Health Sciences. PMID 37398088 DOI: 10.1101/2023.05.30.23290747  0.623
2023 Kitagawa K, Kim KS, Iwamoto M, Hayashi S, Park H, Nishiyama T, Nakamura N, Fujita Y, Nakaoka S, Aihara K, Perelson AS, Allweiss L, Dandri M, Watashi K, Tanaka Y, et al. Multiscale modeling of HBV infection integrating intra- and intercellular viral propagation for analyzing extracellular viral markers. Biorxiv : the Preprint Server For Biology. PMID 37333409 DOI: 10.1101/2023.06.06.543822  0.396
2023 Phan T, Brozak S, Pell B, Ciupe SM, Ke R, Ribeiro RM, Gitter A, Mena KD, Perelson AS, Kuang Y, Wu F. Prolonged viral shedding from noninfectious individuals confounds wastewater-based epidemiology. Medrxiv : the Preprint Server For Health Sciences. PMID 37333173 DOI: 10.1101/2023.06.08.23291144  0.604
2023 Zitzmann C, Dächert C, Schmid B, van der Schaar H, van Hemert M, Perelson AS, van Kuppeveld FJM, Bartenschlager R, Binder M, Kaderali L. Mathematical modeling of plus-strand RNA virus replication to identify broad-spectrum antiviral treatment strategies. Plos Computational Biology. 19: e1010423. PMID 37014904 DOI: 10.1371/journal.pcbi.1010423  0.395
2023 Nair MS, Ribeiro RM, Wang M, Bowen AD, Liu L, Guo Y, Chang JY, Wang P, Sheng Z, Sobieszczyk ME, Perelson AS, Huang Y, Ho DD. Changes in serum-neutralizing antibody potency and breadth post-SARS-CoV-2 mRNA vaccine boost. Iscience. 26: 106345. PMID 36925721 DOI: 10.1016/j.isci.2023.106345  0.462
2023 Fray EJ, Wu F, Simonetti FR, Zitzmann C, Sambaturu N, Molina-Paris C, Bender AM, Liu PT, Ventura JD, Wiseman RW, O'Connor DH, Geleziunas R, Leitner T, Ribeiro RM, Perelson AS, et al. Antiretroviral therapy reveals triphasic decay of intact SIV genomes and persistence of ancestral variants. Cell Host & Microbe. PMID 36809762 DOI: 10.1016/j.chom.2023.01.016  0.653
2023 Chew KW, Moser C, Daar ES, Wohl DA, Li JZ, Coombs RW, Ritz J, Giganti M, Javan AC, Li Y, Choudhary MC, Deo R, Malvestutto C, Klekotka P, Price K, ... ... Perelson AS, et al. Publisher Correction: Antiviral and clinical activity of bamlanivimab in a randomized trial of non-hospitalized adults with COVID-19. Nature Communications. 14: 333. PMID 36658128 DOI: 10.1038/s41467-023-35835-3  0.44
2022 Choudhary MC, Chew KW, Deo R, Flynn JP, Regan J, Crain CR, Moser C, Hughes MD, Ritz J, Ribeiro RM, Ke R, Dragavon JA, Javan AC, Nirula A, Klekotka P, ... ... Perelson AS, et al. Emergence of SARS-CoV-2 escape mutations during Bamlanivimab therapy in a phase II randomized clinical trial. Nature Microbiology. 7: 1906-1917. PMID 36289399 DOI: 10.1038/s41564-022-01254-1  0.555
2022 Chew KW, Moser C, Daar ES, Wohl DA, Li JZ, Coombs RW, Ritz J, Giganti M, Javan AC, Li Y, Choudhary MC, Deo R, Malvestutto C, Klekotka P, Price K, ... ... Perelson AS, et al. Antiviral and clinical activity of bamlanivimab in a randomized trial of non-hospitalized adults with COVID-19. Nature Communications. 13: 4931. PMID 35995785 DOI: 10.1038/s41467-022-32551-2  0.482
2022 Sanche S, Cassidy T, Chu P, Perelson AS, Ribeiro RM, Ke R. A simple model of COVID-19 explains disease severity and the effect of treatments. Scientific Reports. 12: 14210. PMID 35988008 DOI: 10.1038/s41598-022-18244-2  0.579
2022 Zitzmann C, Dächert C, Schmid B, van der Schaar H, van Hemert M, Perelson AS, van Kuppeveld FJM, Bartenschlager R, Binder M, Kaderali L. Mathematical modeling of plus-strand RNA virus replication to identify broad-spectrum antiviral treatment strategies. Biorxiv : the Preprint Server For Biology. PMID 35923314 DOI: 10.1101/2022.07.25.501353  0.395
2022 Kumata R, Iwanami S, Mar KB, Kakizoe Y, Misawa N, Nakaoka S, Koyanagi Y, Perelson AS, Schoggins JW, Iwami S, Sato K. Antithetic effect of interferon-α on cell-free and cell-to-cell HIV-1 infection. Plos Computational Biology. 18: e1010053. PMID 35468127 DOI: 10.1371/journal.pcbi.1010053  0.443
2022 White JA, Simonetti FR, Beg S, McMyn NF, Dai W, Bachmann N, Lai J, Ford WC, Bunch C, Jones JL, Ribeiro RM, Perelson AS, Siliciano JD, Siliciano RF. Complex decay dynamics of HIV virions, intact and defective proviruses, and 2LTR circles following initiation of antiretroviral therapy. Proceedings of the National Academy of Sciences of the United States of America. 119. PMID 35110411 DOI: 10.1073/pnas.2120326119  0.617
2021 Chew KW, Moser C, Daar ES, Wohl DA, Li JZ, Coombs R, Ritz J, Giganti M, Javan AC, Li Y, Malvestutto C, Klekotka P, Price K, Nirula A, Fischer W, ... ... Perelson AS, et al. Bamlanivimab reduces nasopharyngeal SARS-CoV-2 RNA levels but not symptom duration in non-hospitalized adults with COVID-19. Medrxiv : the Preprint Server For Health Sciences. PMID 34981077 DOI: 10.1101/2021.12.17.21268009  0.484
2021 Ke R, Zitzmann C, Ho DD, Ribeiro RM, Perelson AS. In vivo kinetics of SARS-CoV-2 infection and its relationship with a person's infectiousness. Proceedings of the National Academy of Sciences of the United States of America. 118. PMID 34857628 DOI: 10.1073/pnas.2111477118  0.602
2021 Shekhtman L, Navasa M, Sansone N, Crespo G, Subramanya G, Chung TL, Cardozo-Ojeda EF, Pérez-Del-Pulgar S, Perelson AS, Cotler SJ, Forns X, Uprichard SL, Dahari H. Modeling hepatitis C virus kinetics during liver transplantation reveals the role of the liver in virus clearance. Elife. 10. PMID 34730511 DOI: 10.7554/eLife.65297  0.326
2021 Stephenson KE, Julg B, Tan CS, Zash R, Walsh SR, Rolle CP, Monczor AN, Lupo S, Gelderblom HC, Ansel JL, Kanjilal DG, Maxfield LF, Nkolola J, Borducchi EN, Abbink P, ... ... Perelson AS, et al. Safety, pharmacokinetics and antiviral activity of PGT121, a broadly neutralizing monoclonal antibody against HIV-1: a randomized, placebo-controlled, phase 1 clinical trial. Nature Medicine. PMID 34621054 DOI: 10.1038/s41591-021-01509-0  0.331
2021 Choudhary MC, Chew KW, Deo R, Flynn JP, Regan J, Crain CR, Moser C, Hughes M, Ritz J, Ribeiro RM, Ke R, Dragavon JA, Javan AC, Nirula A, Klekotka P, ... ... Perelson AS, et al. Emergence of SARS-CoV-2 Resistance with Monoclonal Antibody Therapy. Medrxiv : the Preprint Server For Health Sciences. PMID 34545376 DOI: 10.1101/2021.09.03.21263105  0.546
2021 Cardozo-Ojeda EF, Perelson AS. Modeling HIV-1 Within-Host Dynamics After Passive Infusion of the Broadly Neutralizing Antibody VRC01. Frontiers in Immunology. 12: 710012. PMID 34531859 DOI: 10.3389/fimmu.2021.710012  0.385
2021 Vaidya NK, Bloomquist A, Perelson AS. Modeling Within-Host Dynamics of SARS-CoV-2 Infection: A Case Study in Ferrets. Viruses. 13. PMID 34452499 DOI: 10.3390/v13081635  0.443
2021 Regan J, Flynn JP, Rosenthal A, Jordan H, Li Y, Chishti R, Giguel F, Corry H, Coxen K, Fajnzylber J, Gillespie E, Kuritzkes DR, Hacohen N, Goldberg MB, Filbin MR, ... ... Perelson AS, et al. Viral Load Kinetics of Severe Acute Respiratory Syndrome Coronavirus 2 in Hospitalized Individuals With Coronavirus Disease 2019. Open Forum Infectious Diseases. 8: ofab153. PMID 34430669 DOI: 10.1093/ofid/ofab153  0.518
2021 Ke R, Zitzmann C, Ho DD, Ribeiro RM, Perelson AS. In vivo kinetics of SARS-CoV-2 infection and its relationship with a person's infectiousness. Medrxiv : the Preprint Server For Health Sciences. PMID 34230935 DOI: 10.1101/2021.06.26.21259581  0.592
2021 Wells CR, Cao Y, Durham DP, Byrareddy SN, Ansari AA, Ruddle NH, Townsend JP, Galvani AP, Perelson AS. Mechanistic basis of post-treatment control of SIV after anti-α4β7 antibody therapy. Plos Computational Biology. 17: e1009031. PMID 34106916 DOI: 10.1371/journal.pcbi.1009031  0.362
2021 McCann CD, van Dorp CH, Danesh A, Ward AR, Dilling TR, Mota TM, Zale E, Stevenson EM, Patel S, Brumme CJ, Dong W, Jones DS, Andresen TL, Walker BD, Brumme ZL, ... ... Perelson AS, et al. A participant-derived xenograft model of HIV enables long-term evaluation of autologous immunotherapies. The Journal of Experimental Medicine. 218. PMID 33988715 DOI: 10.1084/jem.20201908  0.305
2021 Reinharz V, Ishida Y, Tsuge M, Durso-Cain K, Chung TL, Tateno C, Perelson AS, Uprichard SL, Chayama K, Dahari H. Understanding Hepatitis B Virus Dynamics and the Antiviral Effect of Interferon Alpha Treatment in Humanized Chimeric Mice. Journal of Virology. 95: e0049220. PMID 33910953 DOI: 10.1128/JVI.00492-20  0.345
2021 Conway JM, Meily P, Li JZ, Perelson AS. Unified model of short- and long-term HIV viral rebound for clinical trial planning. Journal of the Royal Society, Interface. 18: 20201015. PMID 33849338 DOI: 10.1098/rsif.2020.1015  0.359
2021 Kim KS, Ejima K, Iwanami S, Fujita Y, Ohashi H, Koizumi Y, Asai Y, Nakaoka S, Watashi K, Aihara K, Thompson RN, Ke R, Perelson AS, Iwami S. A quantitative model used to compare within-host SARS-CoV-2, MERS-CoV, and SARS-CoV dynamics provides insights into the pathogenesis and treatment of SARS-CoV-2. Plos Biology. 19: e3001128. PMID 33750978 DOI: 10.1371/journal.pbio.3001128  0.433
2021 Czuppon P, Débarre F, Gonçalves A, Tenaillon O, Perelson AS, Guedj J, Blanquart F. Success of prophylactic antiviral therapy for SARS-CoV-2: Predicted critical efficacies and impact of different drug-specific mechanisms of action. Plos Computational Biology. 17: e1008752. PMID 33647008 DOI: 10.1371/journal.pcbi.1008752  0.423
2021 Mavigner M, Liao LE, Brooks AD, Ke R, Mattingly C, Schoof N, McBrien J, Carnathan D, Liang S, Vanderford TH, Paiardini M, Kulpa D, Lifson JD, Dunham RM, Easley KA, ... ... Perelson AS, et al. CD8 lymphocyte depletion enhances the latency reversal activity of the SMAC mimetic AZD5582 in ART-suppressed SIV-infected rhesus macaques. Journal of Virology. PMID 33568515 DOI: 10.1128/JVI.01429-20  0.435
2021 Best K, Barouch DH, Guedj J, Ribeiro RM, Perelson AS. Zika virus dynamics: Effects of inoculum dose, the innate immune response and viral interference. Plos Computational Biology. 17: e1008564. PMID 33471814 DOI: 10.1371/journal.pcbi.1008564  0.649
2021 Lee S, Goyal A, Perelson AS, Ishida Y, Saito T, Gale M. Suppression of hepatitis B virus through therapeutic activation of RIG-I and IRF3 signaling in hepatocytes. Iscience. 24: 101969. PMID 33458618 DOI: 10.1016/j.isci.2020.101969  0.355
2021 Dahari H, Guedj J, Perelson AS, Layden TJ. Hepatitis C Viral Kinetics in the Era of Direct Acting Antiviral Agents and IL28B. Current Hepatitis Reports. 10: 214-227. PMID 22180724 DOI: 10.1007/s11901-011-0101-7  0.311
2021 Reluga TC, Dahari H, Perelson AS. ANALYSIS OF HEPATITIS C VIRUS INFECTION MODELS WITH HEPATOCYTE HOMEOSTASIS. Siam Journal On Applied Mathematics. 69: 999-1023. PMID 19183708 DOI: 10.1137/080714579  0.462
2021 Dahari H, Layden-Almer JE, Perelson AS, Layden TJ. Hepatitis C Viral Kinetics in Special Populations. Current Hepatitis Reports. 7: 97-105. PMID 19148305 DOI: 10.1007/s11901-008-0022-2  0.384
2020 Zitzmann C, Kaderali L, Perelson AS. Mathematical modeling of hepatitis C RNA replication, exosome secretion and virus release. Plos Computational Biology. 16: e1008421. PMID 33151933 DOI: 10.1371/journal.pcbi.1008421  0.352
2020 Liao LE, Carruthers J, Smither SJ, Weller SA, Williamson D, Laws TR, García-Dorival I, Hiscox J, Holder BP, Beauchemin CAA, Perelson AS, López-García M, Lythe G, Barr J, et al. Quantification of Ebola virus replication kinetics in vitro. Plos Computational Biology. 16: e1008375. PMID 33137116 DOI: 10.1371/journal.pcbi.1008375  0.453
2020 Goyal A, Perelson AS, Kandathil AJ, Quinn J, Balagopal A, Ribeiro RM. HIV influences clustering and intracellular replication of hepatitis C virus. Journal of Viral Hepatitis. PMID 33128322 DOI: 10.1111/jvh.13429  0.614
2020 Balagopal A, Grudda T, Ribeiro RM, Saad YS, Hwang HS, Quinn J, Murphy M, Ward K, Sterling RK, Zhang Y, Perelson AS, Sulkowski MS, Osburn WO, Thio CL. Single hepatocytes show persistence and transcriptional inactivity of hepatitis B. Jci Insight. 5. PMID 33004689 DOI: 10.1172/jci.insight.140584  0.603
2020 van Dorp CH, Conway JM, Barouch DH, Whitney JB, Perelson AS. Models of SIV rebound after treatment interruption that involve multiple reactivation events. Plos Computational Biology. 16: e1008241. PMID 33001979 DOI: 10.1371/journal.pcbi.1008241  0.334
2020 Asokan M, Dias J, Liu C, Maximova A, Ernste K, Pegu A, McKee K, Shi W, Chen X, Almasri C, Promsote W, Ambrozak DR, Gama L, Hu J, Douek DC, ... ... Perelson AS, et al. Fc-mediated effector function contributes to the in vivo antiviral effect of an HIV neutralizing antibody. Proceedings of the National Academy of Sciences of the United States of America. PMID 32690707 DOI: 10.1073/Pnas.2008236117  0.409
2020 Wang P, Gajjar MR, Yu J, Padte NN, Gettie A, Blanchard JL, Russell-Lodrigue K, Liao LE, Perelson AS, Huang Y, Ho DD. Quantifying the contribution of Fc-mediated effector functions to the antiviral activity of anti-HIV-1 IgG1 antibodies in vivo. Proceedings of the National Academy of Sciences of the United States of America. PMID 32665438 DOI: 10.1073/Pnas.2008190117  0.386
2020 Gonçalves A, Bertrand J, Ke R, Comets E, de Lamballerie X, Malvy D, Pizzorno A, Terrier O, Rosa Calatrava M, Mentré F, Smith P, Perelson AS, Guedj J. Timing of antiviral treatment initiation is critical to reduce SARS-CoV-2 viral load. Cpt: Pharmacometrics & Systems Pharmacology. PMID 32558354 DOI: 10.1002/psp4.12543  0.344
2020 Lim SY, Osuna CE, Best K, Taylor R, Chen E, Yoon G, Kublin JL, Schalk D, Schultz-Darken N, Capuano S, Safronetz D, Luo M, MacLennan S, Mathis A, Babu YS, ... ... Perelson AS, et al. A direct-acting antiviral drug abrogates viremia in Zika virus-infected rhesus macaques. Science Translational Medicine. 12. PMID 32522808 DOI: 10.1126/Scitranslmed.Aau9135  0.417
2020 Gonçalves A, Bertrand J, Ke R, Comets E, de Lamballerie X, Malvy D, Pizzorno A, Terrier O, Calatrava MR, Mentré F, Smith P, Perelson AS, Guedj J. Timing of antiviral treatment initiation is critical to reduce SARS-Cov-2 viral load. Medrxiv : the Preprint Server For Health Sciences. PMID 32511641 DOI: 10.1101/2020.04.04.20047886  0.344
2020 Akın E, Yeni G, Perelson AS. Continuous and discrete modeling of HIV-1 decline on therapy. Journal of Mathematical Biology. PMID 32488570 DOI: 10.1007/S00285-020-01492-Z  0.337
2020 Zitzmann C, Schmid B, Ruggieri A, Perelson AS, Binder M, Bartenschlager R, Kaderali L. A Coupled Mathematical Model of the Intracellular Replication of Dengue Virus and the Host Cell Immune Response to Infection. Frontiers in Microbiology. 11: 725. PMID 32411105 DOI: 10.3389/fmicb.2020.00725  0.429
2019 Goyal A, Liao LE, Perelson AS. Within-host mathematical models of hepatitis B virus infection: Past, present, and future. Current Opinion in Systems Biology. 18: 27-35. PMID 31930181 DOI: 10.1016/j.coisb.2019.10.003  0.44
2019 Wang C, Liu D, Zuo T, Hora B, Cai F, Ding H, Kappes J, Ochsenbauer C, Kong W, Yu X, Bhattacharya T, Perelson AS, Gao F. Accumulated mutations by 6 months of infection collectively render transmitted/founder HIV-1 significantly less fit. The Journal of Infection. PMID 31812703 DOI: 10.1016/J.Jinf.2019.12.001  0.341
2019 Wethington D, Harder O, Uppulury K, Stewart WCL, Chen P, King T, Reynolds SD, Perelson AS, Peeples ME, Niewiesk S, Das J. Mathematical modelling identifies the role of adaptive immunity as a key controller of respiratory syncytial virus in cotton rats. Journal of the Royal Society, Interface. 16: 20190389. PMID 31771450 DOI: 10.1098/Rsif.2019.0389  0.389
2019 Hataye JM, Casazza JP, Best K, Liang CJ, Immonen TT, Ambrozak DR, Darko S, Henry AR, Laboune F, Maldarelli F, Douek DC, Hengartner NW, Yamamoto T, Keele BF, Perelson AS, et al. Principles Governing Establishment versus Collapse of HIV-1 Cellular Spread. Cell Host & Microbe. PMID 31761718 DOI: 10.1016/j.chom.2019.10.006  0.404
2019 Cardozo EF, Ji D, Lau G, Schinazi RF, Chen GF, Ribeiro RM, Perelson AS. Disentangling the life-spans of hepatitis C virus infected cells and intracellular vRNA replication-complexes during direct acting antiviral therapy. Journal of Viral Hepatitis. PMID 31670859 DOI: 10.1111/Jvh.13229  0.657
2019 Conway JM, Perelson AS, Li JZ. Predictions of time to HIV viral rebound following ART suspension that incorporate personal biomarkers. Plos Computational Biology. 15: e1007229. PMID 31339888 DOI: 10.1371/Journal.Pcbi.1007229  0.385
2019 Mutua JM, Perelson AS, Kumar A, Vaidya NK. Modeling the Effects of Morphine-Altered Virus Specific Antibody Responses on HIV/SIV Dynamics. Scientific Reports. 9: 5423. PMID 30931971 DOI: 10.1038/s41598-019-41751-8  0.462
2019 Best K, Perelson AS. Mathematical modeling of within-host Zika virus dynamics. Immunological Reviews. 285: 81-96. PMID 30129207 DOI: 10.1111/imr.12687  0.392
2018 Conway JM, Perelson AS. Early HIV infection predictions: role of viral replication errors. Siam Journal On Applied Mathematics. 78: 1863-1890. PMID 31231142 DOI: 10.1137/17M1134019  0.451
2018 Cao Y, Lei X, Ribeiro RM, Perelson AS, Liang J. Probabilistic control of HIV latency and transactivation by the Tat gene circuit. Proceedings of the National Academy of Sciences of the United States of America. PMID 30455316 DOI: 10.1073/Pnas.1811195115  0.566
2018 Ke R, Conway JM, Margolis DM, Perelson AS. Determinants of the efficacy of HIV latency-reversing agents and implications for drug and treatment design. Jci Insight. 3. PMID 30333308 DOI: 10.1172/Jci.Insight.123052  0.316
2018 Kandathil AJ, Sugawara S, Goyal A, Durand CM, Quinn J, Sachithanandham J, Cameron AM, Bailey JR, Perelson AS, Balagopal A. No recovery of replication-competent HIV-1 from human liver macrophages. The Journal of Clinical Investigation. PMID 30198905 DOI: 10.1172/Jci121678  0.3
2018 Perelson AS, Ribeiro RM. Introduction to modeling viral infections and immunity. Immunological Reviews. 285: 5-8. PMID 30129196 DOI: 10.1111/Imr.12700  0.622
2018 Ke R, Li H, Wang S, Ding W, Ribeiro RM, Giorgi EE, Bhattacharya T, Barnard RJO, Hahn BH, Shaw GM, Perelson AS. Superinfection and cure of infected cells as mechanisms for hepatitis C virus adaptation and persistence. Proceedings of the National Academy of Sciences of the United States of America. PMID 29987026 DOI: 10.1073/Pnas.1805267115  0.665
2018 Vaidya NK, Ribeiro RM, Liu P, Haynes BF, Tomaras GD, Perelson AS. Correlation Between Anti-gp41 Antibodies and Virus Infectivity Decay During Primary HIV-1 Infection. Frontiers in Microbiology. 9: 1326. PMID 29973924 DOI: 10.3389/Fmicb.2018.01326  0.626
2018 Quintela BM, Conway JM, Hyman JM, Guedj J, Dos Santos RW, Lobosco M, Perelson AS. A New Age-Structured Multiscale Model of the Hepatitis C Virus Life-Cycle During Infection and Therapy With Direct-Acting Antiviral Agents. Frontiers in Microbiology. 9: 601. PMID 29670586 DOI: 10.3389/Fmicb.2018.00601  0.424
2018 Ishida Y, Chung TL, Imamura M, Hiraga N, Sen S, Yokomichi H, Tateno C, Canini L, Perelson AS, Uprichard SL, Dahari H, Chayama K. Acute HBV infection in humanized chimeric mice has multiphasic viral kinetics. Hepatology (Baltimore, Md.). PMID 29572897 DOI: 10.1002/Hep.29891  0.369
2018 Aunins TR, Marsh KA, Subramanya G, Uprichard SL, Perelson AS, Chatterjee A. Intracellular hepatitis C modeling predicts infection dynamics and viral protein mechanisms. Journal of Virology. PMID 29563295 DOI: 10.1128/Jvi.02098-17  0.461
2017 Canini L, Lemenuel-Diot A, Brennan BJ, Smith PF, Perelson AS. A pharmacokinetic/viral kinetic model to evaluate treatment of chronic HCV infection with a non-nucleoside polymerase inhibitor. Antiviral Therapy. PMID 29317572 DOI: 10.3851/IMP3216  0.384
2017 Goyal A, Ribeiro RM, Perelson AS. The Role of Infected Cell Proliferation in the Clearance of Acute HBV Infection in Humans. Viruses. 9. PMID 29156567 DOI: 10.3390/V9110350  0.636
2017 Nguyen THT, Guedj J, Uprichard SL, Kohli A, Kottilil S, Perelson AS. The paradox of highly effective sofosbuvir-based combination therapy despite slow viral decline: can we still rely on viral kinetics? Scientific Reports. 7: 10233. PMID 28860456 DOI: 10.1038/S41598-017-09776-Z  0.415
2017 Best K, Guedj J, Madelain V, de Lamballerie X, Lim SY, Osuna CE, Whitney JB, Perelson AS. Zika plasma viral dynamics in nonhuman primates provides insights into early infection and antiviral strategies. Proceedings of the National Academy of Sciences of the United States of America. PMID 28765371 DOI: 10.1073/Pnas.1704011114  0.4
2017 Ke R, Cong ME, Li D, Garcia-Lerma G, Perelson AS. On the death rate of abortively infected cells: estimation from simian/human immunodeficiency virus infection. Journal of Virology. PMID 28679753 DOI: 10.1128/JVI.00352-17  0.43
2017 Cardozo EF, Andrade A, Mellors JW, Kuritzkes DR, Perelson AS, Ribeiro RM. Treatment with integrase inhibitor suggests a new interpretation of HIV RNA decay curves that reveals a subset of cells with slow integration. Plos Pathogens. 13: e1006478. PMID 28678879 DOI: 10.1371/Journal.Ppat.1006478  0.676
2017 Aid M, Abbink P, Larocca RA, Boyd M, Nityanandam R, Nanayakkara O, Martinot AJ, Moseley ET, Blass E, Borducchi EN, Chandrashekar A, Brinkman AL, Molloy K, Jetton D, Tartaglia LJ, ... ... Perelson AS, et al. Zika Virus Persistence in the Central Nervous System and Lymph Nodes of Rhesus Monkeys. Cell. PMID 28457610 DOI: 10.1016/j.cell.2017.04.008  0.338
2017 Malespin M, Benyashvili T, Uprichard SL, Perelson AS, Dahari H, Cotler SJ. Prevalence of end of treatment RNA-positive/sustained viral response in HCV patients treated with sofosbuvir combination therapies. Therapeutic Advances in Gastroenterology. 10: 68-73. PMID 28286560 DOI: 10.1177/1756283X16672392  0.341
2017 Koizumi Y, Ohashi H, Nakajima S, Tanaka Y, Wakita T, Perelson AS, Iwami S, Watashi K. Quantifying antiviral activity optimizes drug combinations against hepatitis C virus infection. Proceedings of the National Academy of Sciences of the United States of America. PMID 28174263 DOI: 10.1073/pnas.1610197114  0.367
2016 Lau G, Benhamou Y, Chen G, Li J, Shao Q, Ji D, Li F, Li B, Liu J, Hou J, Sun J, Wang C, Chen J, Wu V, Wong A, ... ... Perelson AS, et al. Efficacy and safety of 3-week response-guided triple direct-acting antiviral therapy for chronic hepatitis C infection: a phase 2, open-label, proof-of-concept study. The Lancet. Gastroenterology & Hepatology. 1: 97-104. PMID 27917405 DOI: 10.1016/S2468-1253(16)30015-2  0.354
2016 Osuna CE, Lim SY, Deleage C, Griffin BD, Stein D, Schroeder LT, Omage R, Best K, Luo M, Hraber PT, Andersen-Elyard H, Ojeda EF, Huang S, Vanlandingham DL, Higgs S, ... Perelson AS, et al. Zika viral dynamics and shedding in rhesus and cynomolgus macaques. Nature Medicine. PMID 27694931 DOI: 10.1038/Nm.4206  0.404
2016 Vaidya NK, Ribeiro RM, Perelson AS, Kumar A. Modeling the Effects of Morphine on Simian Immunodeficiency Virus Dynamics. Plos Computational Biology. 12: e1005127. PMID 27668463 DOI: 10.1371/Journal.Pcbi.1005127  0.64
2016 Graw F, Perelson AS. Modeling Viral Spread. Annual Review of Virology. 3: 555-572. PMID 27618637 DOI: 10.1146/annurev-virology-110615-042249  0.384
2016 Canini L, Guedj J, Perelson AS. Reply to: Danoprevir pharmacokinetic/viral kinetic model for treating chronic HCV - some considerations. Antiviral Therapy. 21: 648-649. PMID 27550924 DOI: 10.3851/IMP3045  0.308
2016 Banerjee S, Guedj J, Ribeiro RM, Moses M, Perelson AS. Estimating biologically relevant parameters under uncertainty for experimental within-host murine West Nile virus infection. Journal of the Royal Society, Interface / the Royal Society. 13. PMID 27075003 DOI: 10.1098/Rsif.2016.0130  0.612
2016 Conway JM, Perelson AS. Residual Viremia in Treated HIV+ Individuals. Plos Computational Biology. 12: e1004677. PMID 26735135 DOI: 10.1371/Journal.Pcbi.1004677  0.45
2015 Love TM, Park SY, Giorgi EE, Mack WJ, Perelson AS, Lee HY. SPMM: estimating infection duration of multi-variant HIV-1 infections. Bioinformatics (Oxford, England). PMID 26722117 DOI: 10.1093/Bioinformatics/Btv749  0.37
2015 Immonen TT, Conway JM, Romero-Severson EO, Perelson AS, Leitner T. Recombination Enhances HIV-1 Envelope Diversity by Facilitating the Survival of Latent Genomic Fragments in the Plasma Virus Population. Plos Computational Biology. 11: e1004625. PMID 26693708 DOI: 10.1371/Journal.Pcbi.1004625  0.349
2015 Andrade A, Guedj J, Rosenkranz SL, Lu D, Mellors J, Kuritzkes DR, Perelson AS, Ribeiro RM. Early HIV RNA decay during raltegravir-containing regimens exhibits two distinct subphases (1a and 1b). Aids (London, England). 29: 2419-26. PMID 26558541 DOI: 10.1097/Qad.0000000000000843  0.627
2015 Canini L, Guedj J, Chatterjee A, Lemenuel-Diot A, Smith PF, Perelson AS. Modelling the interaction between danoprevir and mericitabine in the treatment of chronic HCV infection. Antiviral Therapy. PMID 26555159 DOI: 10.3851/Imp3006  0.324
2015 Ke R, Lewin SR, Elliott JH, Perelson AS. Modeling the Effects of Vorinostat In Vivo Reveals both Transient and Delayed HIV Transcriptional Activation and Minimal Killing of Latently Infected Cells. Plos Pathogens. 11: e1005237. PMID 26496627 DOI: 10.1371/journal.ppat.1005237  0.318
2015 Li H, Stoddard M, Wang S, Giorgi EE, Blair L, Learn G, Hahn B, Alter H, Busch M, Fierer D, Ribeiro RM, Perelson AS, Bhattacharya T, Shaw GM. Single Genome Sequencing of Hepatitis C Virus in Donor-Recipient Pairs Distinguishes Modes and Models of Virus Transmission and Early Diversification. Journal of Virology. PMID 26468546 DOI: 10.1128/Jvi.02156-15  0.624
2015 Perelson AS, Guedj J. Modelling hepatitis C therapy--predicting effects of treatment. Nature Reviews. Gastroenterology & Hepatology. 12: 437-45. PMID 26122475 DOI: 10.1038/nrgastro.2015.97  0.367
2015 Conway JM, Perelson AS. Post-treatment control of HIV infection. Proceedings of the National Academy of Sciences of the United States of America. 112: 5467-72. PMID 25870266 DOI: 10.1073/Pnas.1419162112  0.414
2015 Graw F, Martin DN, Perelson AS, Uprichard SL, Dahari H. Quantification of Hepatitis C Virus Cell-to-Cell Spread Using a Stochastic Modeling Approach. Journal of Virology. 89: 6551-61. PMID 25833046 DOI: 10.1128/Jvi.00016-15  0.338
2015 Yue L, Pfafferott KJ, Baalwa J, Conrod K, Dong CC, Chui C, Rong R, Claiborne DT, Prince JL, Tang J, Ribeiro RM, Cormier E, Hahn BH, Perelson AS, Shaw GM, et al. Transmitted virus fitness and host T cell responses collectively define divergent infection outcomes in two HIV-1 recipients. Plos Pathogens. 11: e1004565. PMID 25569444 DOI: 10.1371/Journal.Ppat.1004565  0.672
2014 Graw F, Balagopal A, Kandathil AJ, Ray SC, Thomas DL, Ribeiro RM, Perelson AS. Inferring viral dynamics in chronically HCV infected patients from the spatial distribution of infected hepatocytes. Plos Computational Biology. 10: e1003934. PMID 25393308 DOI: 10.1371/Journal.Pcbi.1003934  0.629
2014 Althaus CL, Joos B, Perelson AS, Günthard HF. Quantifying the turnover of transcriptional subclasses of HIV-1-infected cells. Plos Computational Biology. 10: e1003871. PMID 25340797 DOI: 10.1371/journal.pcbi.1003871  0.439
2014 Canini L, Chatterjee A, Guedj J, Lemenuel-Diot A, Brennan B, Smith PF, Perelson AS. A pharmacokinetic/viral kinetic model to evaluate the treatment effectiveness of danoprevir against chronic HCV. Antiviral Therapy. PMID 25321394 DOI: 10.3851/Imp2879  0.335
2014 Miao H, Sangster MY, Livingstone AM, Hilchey SP, Zhang L, Topham DJ, Mosmann TR, Holden-Wiltse J, Perelson AS, Wu H, Zand MS. Modeling the dynamics and migratory pathways of virus-specific antibody-secreting cell populations in primary influenza infection. Plos One. 9: e104781. PMID 25171166 DOI: 10.1371/Journal.Pone.0104781  0.316
2014 Conway JM, Perelson AS. A hepatitis C virus infection model with time-varying drug effectiveness: solution and analysis. Plos Computational Biology. 10: e1003769. PMID 25101902 DOI: 10.1371/Journal.Pcbi.1003769  0.386
2014 Sherman KE, Guedj J, Shata MT, Blackard JT, Rouster SD, Castro M, Feinberg J, Sterling RK, Goodman Z, Aronow BJ, Perelson AS. Modulation of HCV replication after combination antiretroviral therapy in HCV/HIV co-infected patients. Science Translational Medicine. 6: 246ra98. PMID 25101888 DOI: 10.1126/Scitranslmed.3008195  0.385
2014 Ciupe SM, Ribeiro RM, Perelson AS. Antibody responses during hepatitis B viral infection. Plos Computational Biology. 10: e1003730. PMID 25078553 DOI: 10.1371/Journal.Pcbi.1003730  0.635
2014 Canini L, Perelson AS. Viral kinetic modeling: state of the art. Journal of Pharmacokinetics and Pharmacodynamics. 41: 431-43. PMID 24961742 DOI: 10.1007/s10928-014-9363-3  0.353
2014 Canini L, Conway JM, Perelson AS, Carrat F. Impact of different oseltamivir regimens on treating influenza A virus infection and resistance emergence: insights from a modelling study. Plos Computational Biology. 10: e1003568. PMID 24743564 DOI: 10.1371/Journal.Pcbi.1003568  0.303
2014 Hernandez-Vargas EA, Wilk E, Canini L, Toapanta FR, Binder SC, Uvarovskii A, Ross TM, Guzmán CA, Perelson AS, Meyer-Hermann M. Effects of aging on influenza virus infection dynamics. Journal of Virology. 88: 4123-31. PMID 24478442 DOI: 10.1128/Jvi.03644-13  0.362
2014 Fletcher CV, Staskus K, Wietgrefe SW, Rothenberger M, Reilly C, Chipman JG, Beilman GJ, Khoruts A, Thorkelson A, Schmidt TE, Anderson J, Perkey K, Stevenson M, Perelson AS, Douek DC, et al. Persistent HIV-1 replication is associated with lower antiretroviral drug concentrations in lymphatic tissues. Proceedings of the National Academy of Sciences of the United States of America. 111: 2307-12. PMID 24469825 DOI: 10.1073/Pnas.1318249111  0.349
2014 Guedj J, Pang PS, Denning J, Rodriguez-Torres M, Lawitz E, Symonds W, Perelson AS. Analysis of hepatitis C viral kinetics during administration of two nucleotide analogues: sofosbuvir (GS-7977) and GS-0938. Antiviral Therapy. 19: 211-20. PMID 24464551 DOI: 10.3851/IMP2733  0.334
2014 Guedj J, Yu J, Levi M, Li B, Kern S, Naoumov NV, Perelson AS. Modeling viral kinetics and treatment outcome during alisporivir interferon-free treatment in hepatitis C virus genotype 2 and 3 patients. Hepatology (Baltimore, Md.). 59: 1706-14. PMID 24375768 DOI: 10.1002/hep.26989  0.371
2013 Ganusov VV, Neher RA, Perelson AS. Mathematical modeling of escape of HIV from cytotoxic T lymphocyte responses. Journal of Statistical Mechanics (Online). 2013: P01010. PMID 24660019 DOI: 10.1088/1742-5468/2013/01/P01010  0.402
2013 Kessinger TA, Perelson AS, Neher RA. Inferring HIV Escape Rates from Multi-Locus Genotype Data. Frontiers in Immunology. 4: 252. PMID 24027569 DOI: 10.3389/fimmu.2013.00252  0.369
2013 Perelson AS, Ribeiro RM. Modeling the within-host dynamics of HIV infection. Bmc Biology. 11: 96. PMID 24020860 DOI: 10.1186/1741-7007-11-96  0.634
2013 Kandathil AJ, Graw F, Quinn J, Hwang HS, Torbenson M, Perelson AS, Ray SC, Thomas DL, Ribeiro RM, Balagopal A. Use of laser capture microdissection to map hepatitis C virus-positive hepatocytes in human liver. Gastroenterology. 145: 1404-13.e1-10. PMID 23973767 DOI: 10.1053/J.Gastro.2013.08.034  0.592
2013 Guedj J, Dahari H, Uprichard SL, Perelson AS. The hepatitis C virus NS5A inhibitor daclatasvir has a dual mode of action and leads to a new virus half-life estimate. Expert Review of Gastroenterology & Hepatology. 7: 397-9. PMID 23899277 DOI: 10.1586/17474124.2013.811050  0.396
2013 Rong L, Perelson AS. Mathematical analysis of multiscale models for hepatitis C virus dynamics under therapy with direct-acting antiviral agents. Mathematical Biosciences. 245: 22-30. PMID 23684949 DOI: 10.1016/J.Mbs.2013.04.012  0.45
2013 Murillo LN, Murillo MS, Perelson AS. Towards multiscale modeling of influenza infection. Journal of Theoretical Biology. 332: 267-90. PMID 23608630 DOI: 10.1016/J.Jtbi.2013.03.024  0.318
2013 Giorgi EE, Korber BT, Perelson AS, Bhattacharya T. Modeling sequence evolution in HIV-1 infection with recombination. Journal of Theoretical Biology. 329: 82-93. PMID 23567647 DOI: 10.1016/J.Jtbi.2013.03.026  0.311
2013 Smith AM, Adler FR, Ribeiro RM, Gutenkunst RN, McAuley JL, McCullers JA, Perelson AS. Kinetics of coinfection with influenza A virus and Streptococcus pneumoniae. Plos Pathogens. 9: e1003238. PMID 23555251 DOI: 10.1371/Journal.Ppat.1003238  0.584
2013 Rong L, Guedj J, Dahari H, Coffield DJ, Levi M, Smith P, Perelson AS. Analysis of hepatitis C virus decline during treatment with the protease inhibitor danoprevir using a multiscale model. Plos Computational Biology. 9: e1002959. PMID 23516348 DOI: 10.1371/Journal.Pcbi.1002959  0.463
2013 Guedj J, Dahari H, Rong L, Sansone ND, Nettles RE, Cotler SJ, Layden TJ, Uprichard SL, Perelson AS. Modeling shows that the NS5A inhibitor daclatasvir has two modes of action and yields a shorter estimate of the hepatitis C virus half-life. Proceedings of the National Academy of Sciences of the United States of America. 110: 3991-6. PMID 23431163 DOI: 10.1073/Pnas.1203110110  0.344
2013 Arazi A, Pendergraft WF, Ribeiro RM, Perelson AS, Hacohen N. Human systems immunology: hypothesis-based modeling and unbiased data-driven approaches. Seminars in Immunology. 25: 193-200. PMID 23375135 DOI: 10.1016/J.Smim.2012.11.003  0.511
2013 Zhang J, Lipton HL, Perelson AS, Dahari H. Modeling the acute and chronic phases of Theiler murine encephalomyelitis virus infection. Journal of Virology. 87: 4052-9. PMID 23365440 DOI: 10.1128/JVI.03395-12  0.357
2013 Chatterjee A, Smith PF, Perelson AS. Hepatitis C viral kinetics: the past, present, and future. Clinics in Liver Disease. 17: 13-26. PMID 23177280 DOI: 10.1016/J.Cld.2012.09.003  0.318
2013 Lau DT, Negash A, Chen J, Crochet N, Sinha M, Zhang Y, Guedj J, Holder S, Saito T, Lemon SM, Luxon BA, Perelson AS, Gale M. Innate immune tolerance and the role of kupffer cells in differential responses to interferon therapy among patients with HCV genotype 1 infection. Gastroenterology. 144: 402-413.e12. PMID 23123437 DOI: 10.1053/J.Gastro.2012.10.044  0.348
2012 Chatterjee A, Guedj J, Perelson AS. Mathematical modelling of HCV infection: what can it teach us in the era of direct-acting antiviral agents? Antiviral Therapy. 17: 1171-82. PMID 23186606 DOI: 10.3851/Imp2428  0.41
2012 Ribeiro RM, Li H, Wang S, Stoddard MB, Learn GH, Korber BT, Bhattacharya T, Guedj J, Parrish EH, Hahn BH, Shaw GM, Perelson AS. Quantifying the diversification of hepatitis C virus (HCV) during primary infection: estimates of the in vivo mutation rate. Plos Pathogens. 8: e1002881. PMID 22927817 DOI: 10.1371/Journal.Ppat.1002881  0.651
2012 Li H, Stoddard MB, Wang S, Blair LM, Giorgi EE, Parrish EH, Learn GH, Hraber P, Goepfert PA, Saag MS, Denny TN, Haynes BF, Hahn BH, Ribeiro RM, Perelson AS, et al. Elucidation of hepatitis C virus transmission and early diversification by single genome sequencing. Plos Pathogens. 8: e1002880. PMID 22927816 DOI: 10.1371/Journal.Ppat.1002880  0.649
2012 Pawelek KA, Huynh GT, Quinlivan M, Cullinane A, Rong L, Perelson AS. Modeling within-host dynamics of influenza virus infection including immune responses. Plos Computational Biology. 8: e1002588. PMID 22761567 DOI: 10.1371/Journal.Pcbi.1002588  0.438
2012 Zhou Y, Callendret B, Xu D, Brasky KM, Feng Z, Hensley LL, Guedj J, Perelson AS, Lemon SM, Lanford RE, Walker CM. Dominance of the CD4(+) T helper cell response during acute resolving hepatitis A virus infection. The Journal of Experimental Medicine. 209: 1481-92. PMID 22753925 DOI: 10.1084/Jem.20111906  0.38
2012 Chaudhury S, Perelson AS, Sinitstyn NA. Spontaneous clearance of viral infections by mesoscopic fluctuations. Plos One. 7: e38549. PMID 22693646 DOI: 10.1371/Journal.Pone.0038549  0.443
2012 Bar KJ, Tsao CY, Iyer SS, Decker JM, Yang Y, Bonsignori M, Chen X, Hwang KK, Montefiori DC, Liao HX, Hraber P, Fischer W, Li H, Wang S, Sterrett S, ... ... Perelson AS, et al. Early low-titer neutralizing antibodies impede HIV-1 replication and select for virus escape. Plos Pathogens. 8: e1002721. PMID 22693447 DOI: 10.1371/Journal.Ppat.1002721  0.36
2012 Archin NM, Vaidya NK, Kuruc JD, Liberty AL, Wiegand A, Kearney MF, Cohen MS, Coffin JM, Bosch RJ, Gay CL, Eron JJ, Margolis DM, Perelson AS. Immediate antiviral therapy appears to restrict resting CD4+ cell HIV-1 infection without accelerating the decay of latent infection. Proceedings of the National Academy of Sciences of the United States of America. 109: 9523-8. PMID 22645358 DOI: 10.1073/pnas.1120248109  0.394
2012 Rong L, Ribeiro RM, Perelson AS. Modeling quasispecies and drug resistance in hepatitis C patients treated with a protease inhibitor. Bulletin of Mathematical Biology. 74: 1789-817. PMID 22639338 DOI: 10.1007/S11538-012-9736-Y  0.596
2012 De Boer RJ, Perelson AS, Ribeiro RM. Modelling deuterium labelling of lymphocytes with temporal and/or kinetic heterogeneity. Journal of the Royal Society, Interface / the Royal Society. 9: 2191-200. PMID 22513720 DOI: 10.1098/Rsif.2012.0149  0.535
2012 Guedj J, Dahari H, Pohl RT, Ferenci P, Perelson AS. Understanding silibinin's modes of action against HCV using viral kinetic modeling. Journal of Hepatology. 56: 1019-1024. PMID 22245888 DOI: 10.1016/j.jhep.2011.12.012  0.342
2012 Guedj J, Dahari H, Shudo E, Smith P, Perelson AS. Hepatitis C viral kinetics with the nucleoside polymerase inhibitor mericitabine (RG7128). Hepatology (Baltimore, Md.). 55: 1030-7. PMID 22095398 DOI: 10.1002/hep.24788  0.371
2011 Wu H, Kumar A, Miao H, Holden-Wiltse J, Mosmann TR, Livingstone AM, Belz GT, Perelson AS, Zand MS, Topham DJ. Modeling of influenza-specific CD8+ T cells during the primary response indicates that the spleen is a major source of effectors. Journal of Immunology (Baltimore, Md. : 1950). 187: 4474-82. PMID 21948988 DOI: 10.4049/Jimmunol.1101443  0.318
2011 Asmal M, Hellmann I, Liu W, Keele BF, Perelson AS, Bhattacharya T, Gnanakaran S, Daniels M, Haynes BF, Korber BT, Hahn BH, Shaw GM, Letvin NL. A signature in HIV-1 envelope leader peptide associated with transition from acute to chronic infection impacts envelope processing and infectivity. Plos One. 6: e23673. PMID 21876761 DOI: 10.1371/Journal.Pone.0023673  0.369
2011 Liu P, Overman RG, Yates NL, Alam SM, Vandergrift N, Chen Y, Graw F, Freel SA, Kappes JC, Ochsenbauer C, Montefiori DC, Gao F, Perelson AS, Cohen MS, Haynes BF, et al. Dynamic antibody specificities and virion concentrations in circulating immune complexes in acute to chronic HIV-1 infection. Journal of Virology. 85: 11196-207. PMID 21865397 DOI: 10.1128/Jvi.05601-11  0.339
2011 Ganusov VV, Goonetilleke N, Liu MK, Ferrari G, Shaw GM, McMichael AJ, Borrow P, Korber BT, Perelson AS. Fitness costs and diversity of the cytotoxic T lymphocyte (CTL) response determine the rate of CTL escape during acute and chronic phases of HIV infection. Journal of Virology. 85: 10518-28. PMID 21835793 DOI: 10.1128/Jvi.00655-11  0.454
2011 Perelson AS, Deeks SG. Drug effectiveness explained: the mathematics of antiviral agents for HIV. Science Translational Medicine. 3: 91ps30. PMID 21753120 DOI: 10.1126/scitranslmed.3002656  0.307
2011 Guedj J, Dahari H, Perelson AS. Understanding the nature of early HCV RNA blips and the use of mathematical modeling of viral kinetics during IFN-based therapy. Proceedings of the National Academy of Sciences of the United States of America. 108: E302; author reply E. PMID 21719708 DOI: 10.1073/pnas.1104149108  0.308
2011 Lanford RE, Feng Z, Chavez D, Guerra B, Brasky KM, Zhou Y, Yamane D, Perelson AS, Walker CM, Lemon SM. Acute hepatitis A virus infection is associated with a limited type I interferon response and persistence of intrahepatic viral RNA. Proceedings of the National Academy of Sciences of the United States of America. 108: 11223-8. PMID 21690403 DOI: 10.1073/Pnas.1101939108  0.439
2011 Weinberger AD, Perelson AS. Persistence and emergence of X4 virus in HIV infection Mathematical Biosciences and Engineering. 8: 605-626. PMID 21631149 DOI: 10.3934/mbe.2011.8.605  0.328
2011 Wang D, Hicks CB, Goswami ND, Tafoya E, Ribeiro RM, Cai F, Perelson AS, Gao F. Evolution of drug-resistant viral populations during interruption of antiretroviral therapy. Journal of Virology. 85: 6403-15. PMID 21490094 DOI: 10.1128/Jvi.02389-10  0.537
2011 Guedj J, Perelson AS. Second-phase hepatitis C virus RNA decline during telaprevir-based therapy increases with drug effectiveness: implications for treatment duration. Hepatology (Baltimore, Md.). 53: 1801-8. PMID 21384401 DOI: 10.1002/hep.24272  0.453
2011 Smith AM, Adler FR, McAuley JL, Gutenkunst RN, Ribeiro RM, McCullers JA, Perelson AS. Effect of 1918 PB1-F2 expression on influenza A virus infection kinetics. Plos Computational Biology. 7: e1001081. PMID 21379324 DOI: 10.1371/Journal.Pcbi.1001081  0.588
2011 Pearson JE, Krapivsky P, Perelson AS. Stochastic theory of early viral infection: continuous versus burst production of virions. Plos Computational Biology. 7: e1001058. PMID 21304934 DOI: 10.1371/journal.pcbi.1001058  0.384
2011 Smith AM, Perelson AS. Influenza A virus infection kinetics: quantitative data and models. Wiley Interdisciplinary Reviews. Systems Biology and Medicine. 3: 429-45. PMID 21197654 DOI: 10.1002/wsbm.129  0.328
2010 Vaidya NK, Rong L, Marconi VC, Kuritzkes DR, Deeks SG, Perelson AS. Treatment-mediated alterations in HIV fitness preserve CD4+ T cell counts but have minimal effects on viral load. Plos Computational Biology. 6: e1001012. PMID 21124866 DOI: 10.1371/Journal.Pcbi.1001012  0.378
2010 Giorgi EE, Funkhouser B, Athreya G, Perelson AS, Korber BT, Bhattacharya T. Estimating time since infection in early homogeneous HIV-1 samples using a poisson model. Bmc Bioinformatics. 11: 532. PMID 20973976 DOI: 10.1186/1471-2105-11-532  0.303
2010 Ribeiro RM, Germanidis G, Powers KA, Pellegrin B, Nikolaidis P, Perelson AS, Pawlotsky JM. Hepatitis B virus kinetics under antiviral therapy sheds light on differences in hepatitis B e antigen positive and negative infections. The Journal of Infectious Diseases. 202: 1309-18. PMID 20874517 DOI: 10.1086/656528  0.612
2010 De Boer RJ, Ribeiro RM, Perelson AS. Current estimates for HIV-1 production imply rapid viral clearance in lymphoid tissues. Plos Computational Biology. 6: e1000906. PMID 20824126 DOI: 10.1371/Journal.Pcbi.1000906  0.622
2010 Fischer W, Ganusov VV, Giorgi EE, Hraber PT, Keele BF, Leitner T, Han CS, Gleasner CD, Green L, Lo CC, Nag A, Wallstrom TC, Wang S, McMichael AJ, Haynes BF, ... ... Perelson AS, et al. Transmission of single HIV-1 genomes and dynamics of early immune escape revealed by ultra-deep sequencing. Plos One. 5: e12303. PMID 20808830 DOI: 10.1371/Journal.Pone.0012303  0.37
2010 Li H, Bar KJ, Wang S, Decker JM, Chen Y, Sun C, Salazar-Gonzalez JF, Salazar MG, Learn GH, Morgan CJ, Schumacher JE, Hraber P, Giorgi EE, Bhattacharya T, Korber BT, ... Perelson AS, et al. High Multiplicity Infection by HIV-1 in Men Who Have Sex with Men. Plos Pathogens. 6: e1000890. PMID 20485520 DOI: 10.1371/Journal.Ppat.1000890  0.39
2010 Rong L, Dahari H, Ribeiro RM, Perelson AS. Rapid emergence of protease inhibitor resistance in hepatitis C virus. Science Translational Medicine. 2: 30ra32. PMID 20445200 DOI: 10.1126/Scitranslmed.3000544  0.639
2010 Miao H, Hollenbaugh JA, Zand MS, Holden-Wiltse J, Mosmann TR, Perelson AS, Wu H, Topham DJ. Quantifying the early immune response and adaptive immune response kinetics in mice infected with influenza A virus. Journal of Virology. 84: 6687-98. PMID 20410284 DOI: 10.1128/Jvi.00266-10  0.416
2010 Rong L, Perelson AS. Treatment of hepatitis C virus infection with interferon and small molecule direct antivirals: viral kinetics and modeling. Critical Reviews in Immunology. 30: 131-48. PMID 20370626 DOI: 10.1615/Critrevimmunol.V30.I2.30  0.395
2010 Ribeiro RM, Qin L, Chavez LL, Li D, Self SG, Perelson AS. Estimation of the initial viral growth rate and basic reproductive number during acute HIV-1 infection. Journal of Virology. 84: 6096-102. PMID 20357090 DOI: 10.1128/Jvi.00127-10  0.653
2010 Vaidya NK, Ribeiro RM, Miller CJ, Perelson AS. Viral dynamics during primary simian immunodeficiency virus infection: effect of time-dependent virus infectivity. Journal of Virology. 84: 4302-10. PMID 20147390 DOI: 10.1128/Jvi.02284-09  0.657
2010 Klatt NR, Shudo E, Ortiz AM, Engram JC, Paiardini M, Lawson B, Miller MD, Else J, Pandrea I, Estes JD, Apetrei C, Schmitz JE, Ribeiro RM, Perelson AS, Silvestri G. CD8+ lymphocytes control viral replication in SIVmac239-infected rhesus macaques without decreasing the lifespan of productively infected cells. Plos Pathogens. 6: e1000747. PMID 20126441 DOI: 10.1371/Journal.Ppat.1000747  0.632
2010 Smith AM, Adler FR, Perelson AS. An accurate two-phase approximate solution to an acute viral infection model. Journal of Mathematical Biology. 60: 711-26. PMID 19633852 DOI: 10.1007/S00285-009-0281-8  0.37
2009 Rong L, Perelson AS. Modeling latently infected cell activation: viral and latent reservoir persistence, and viral blips in HIV-infected patients on potent therapy. Plos Computational Biology. 5: e1000533. PMID 19834532 DOI: 10.1371/Journal.Pcbi.1000533  0.457
2009 Weinberger AD, Perelson AS, Ribeiro RM, Weinberger LS. Accelerated immunodeficiency by anti-CCR5 treatment in HIV infection. Plos Computational Biology. 5: e1000467. PMID 19680436 DOI: 10.1371/Journal.Pcbi.1000467  0.621
2009 Lee HY, Giorgi EE, Keele BF, Gaschen B, Athreya GS, Salazar-Gonzalez JF, Pham KT, Goepfert PA, Kilby JM, Saag MS, Delwart EL, Busch MP, Hahn BH, Shaw GM, Korber BT, ... ... Perelson AS, et al. Modeling sequence evolution in acute HIV-1 infection. Journal of Theoretical Biology. 261: 341-60. PMID 19660475 DOI: 10.1016/J.Jtbi.2009.07.038  0.41
2009 Rong L, Perelson AS. Modeling HIV persistence, the latent reservoir, and viral blips. Journal of Theoretical Biology. 260: 308-31. PMID 19539630 DOI: 10.1016/J.Jtbi.2009.06.011  0.364
2009 Salazar-Gonzalez JF, Salazar MG, Keele BF, Learn GH, Giorgi EE, Li H, Decker JM, Wang S, Baalwa J, Kraus MH, Parrish NF, Shaw KS, Guffey MB, Bar KJ, Davis KL, ... ... Perelson AS, et al. Genetic identity, biological phenotype, and evolutionary pathways of transmitted/founder viruses in acute and early HIV-1 infection. The Journal of Experimental Medicine. 206: 1273-89. PMID 19487424 DOI: 10.1084/Jem.20090378  0.383
2009 Goonetilleke N, Liu MK, Salazar-Gonzalez JF, Ferrari G, Giorgi E, Ganusov VV, Keele BF, Learn GH, Turnbull EL, Salazar MG, Weinhold KJ, Moore S, Letvin N, Haynes BF, ... ... Perelson AS, et al. The first T cell response to transmitted/founder virus contributes to the control of acute viremia in HIV-1 infection. The Journal of Experimental Medicine. 206: 1253-72. PMID 19487423 DOI: 10.1084/Jem.20090365  0.424
2009 Dahari H, Shudo E, Cotler SJ, Layden TJ, Perelson AS. Modelling hepatitis C virus kinetics: The relationship between the infected cell loss rate and the final slope of viral decay Antiviral Therapy. 14: 459-464. PMID 19474480  0.463
2009 Lee HY, Topham DJ, Park SY, Hollenbaugh J, Treanor J, Mosmann TR, Jin X, Ward BM, Miao H, Holden-Wiltse J, Perelson AS, Zand M, Wu H. Simulation and prediction of the adaptive immune response to influenza A virus infection. Journal of Virology. 83: 7151-65. PMID 19439465 DOI: 10.1128/Jvi.00098-09  0.416
2009 Keele BF, Li H, Learn GH, Hraber P, Giorgi EE, Grayson T, Sun C, Chen Y, Yeh WW, Letvin NL, Mascola JR, Nabel GJ, Haynes BF, Bhattacharya T, Perelson AS, et al. Low-dose rectal inoculation of rhesus macaques by SIVsmE660 or SIVmac251 recapitulates human mucosal infection by HIV-1. The Journal of Experimental Medicine. 206: 1117-34. PMID 19414559 DOI: 10.1084/Jem.20082831  0.407
2009 Shudo E, Ribeiro RM, Perelson AS. Modeling HCV kinetics under therapy using PK and PD information. Expert Opinion On Drug Metabolism & Toxicology. 5: 321-32. PMID 19331594 DOI: 10.1517/17425250902787616  0.586
2009 Dahari H, Layden-Almer JE, Kallwitz E, Ribeiro RM, Cotler SJ, Layden TJ, Perelson AS. A mathematical model of hepatitis C virus dynamics in patients with high baseline viral loads or advanced liver disease. Gastroenterology. 136: 1402-9. PMID 19208338 DOI: 10.1053/J.Gastro.2008.12.060  0.595
2009 Lewin SR, Ribeiro RM, Avihingsanon A, Bowden S, Matthews G, Marks P, Locarnini SA, Ruxrungtham K, Perelson AS, Dore GJ. Viral dynamics of hepatitis B virus DNA in human immunodeficiency virus-1-hepatitis B virus coinfected individuals: similar effectiveness of lamivudine, tenofovir, or combination therapy. Hepatology (Baltimore, Md.). 49: 1113-21. PMID 19115219 DOI: 10.1002/Hep.22754  0.678
2009 Dahari H, Shudo E, Ribeiro RM, Perelson AS. Modeling complex decay profiles of hepatitis B virus during antiviral therapy. Hepatology (Baltimore, Md.). 49: 32-8. PMID 19065674 DOI: 10.1002/Hep.22586  0.604
2009 Dahari H, Shudo E, Ribeiro RM, Perelson AS. Mathematical modeling of HCV infection and treatment. Methods in Molecular Biology (Clifton, N.J.). 510: 439-53. PMID 19009281 DOI: 10.1007/978-1-59745-394-3_33  0.64
2009 Rong L, Perelson AS. Asymmetric division of activated latently infected cells may explain the decay kinetics of the HIV-1 latent reservoir and intermittent viral blips. Mathematical Biosciences. 217: 77-87. PMID 18977369 DOI: 10.1016/J.Mbs.2008.10.006  0.465
2008 Shudo E, Ribeiro RM, Talal AH, Perelson AS. A hepatitis C viral kinetic model that allows for time-varying drug effectiveness. Antiviral Therapy. 13: 919-26. PMID 19043926  0.587
2008 Tomaras GD, Yates NL, Liu P, Qin L, Fouda GG, Chavez LL, Decamp AC, Parks RJ, Ashley VC, Lucas JT, Cohen M, Eron J, Hicks CB, Liao HX, Self SG, ... ... Perelson AS, et al. Initial B-cell responses to transmitted human immunodeficiency virus type 1: virion-binding immunoglobulin M (IgM) and IgG antibodies followed by plasma anti-gp41 antibodies with ineffective control of initial viremia. Journal of Virology. 82: 12449-63. PMID 18842730 DOI: 10.1128/Jvi.01708-08  0.338
2008 Chavez LL, Davenport MP, Shiver JW, Tussey LG, Cox KS, Bachinsky M, Wang F, Huang L, Schleif WA, Davies ME, Tang A, Casimiro DR, Perelson AS, Ribeiro RM. The effect of early versus delayed challenge after vaccination in controlling SHIV 89.6P infection. Virology. 381: 75-80. PMID 18793788 DOI: 10.1016/J.Virol.2008.07.042  0.573
2008 Beauchemin CA, McSharry JJ, Drusano GL, Nguyen JT, Went GT, Ribeiro RM, Perelson AS. Modeling amantadine treatment of influenza A virus in vitro. Journal of Theoretical Biology. 254: 439-51. PMID 18653201 DOI: 10.1016/J.Jtbi.2008.05.031  0.632
2008 Keele BF, Giorgi EE, Salazar-Gonzalez JF, Decker JM, Pham KT, Salazar MG, Sun C, Grayson T, Wang S, Li H, Wei X, Jiang C, Kirchherr JL, Gao F, Anderson JA, ... ... Perelson AS, et al. Identification and characterization of transmitted and early founder virus envelopes in primary HIV-1 infection. Proceedings of the National Academy of Sciences of the United States of America. 105: 7552-7. PMID 18490657 DOI: 10.1073/Pnas.0802203105  0.424
2008 Kilby JM, Lee HY, Hazelwood JD, Bansal A, Bucy RP, Saag MS, Shaw GM, Acosta EP, Johnson VA, Perelson AS, Goepfert PA. Treatment response in acute/early infection versus advanced AIDS: equivalent first and second phases of HIV RNA decline. Aids (London, England). 22: 957-62. PMID 18453855 DOI: 10.1097/Qad.0B013E3282Fbd1Da  0.346
2008 Tuckwell HC, Shipman PD, Perelson AS. The probability of HIV infection in a new host and its reduction with microbicides. Mathematical Biosciences. 214: 81-6. PMID 18445499 DOI: 10.1016/J.Mbs.2008.03.005  0.312
2008 Soriano V, Perelson AS, Zoulim F. Why are there different dynamics in the selection of drug resistance in HIV and hepatitis B and C viruses? The Journal of Antimicrobial Chemotherapy. 62: 1-4. PMID 18441341 DOI: 10.1093/jac/dkn175  0.397
2008 Pandrea I, Ribeiro RM, Gautam R, Gaufin T, Pattison M, Barnes M, Monjure C, Stoulig C, Dufour J, Cyprian W, Silvestri G, Miller MD, Perelson AS, Apetrei C. Simian immunodeficiency virus SIVagm dynamics in African green monkeys. Journal of Virology. 82: 3713-24. PMID 18216122 DOI: 10.1128/Jvi.02402-07  0.678
2008 Gordon SN, Dunham RM, Engram JC, Estes J, Wang Z, Klatt NR, Paiardini M, Pandrea IV, Apetrei C, Sodora DL, Lee HY, Haase AT, Miller MD, Kaur A, Staprans SI, ... Perelson AS, et al. Short-lived infected cells support virus replication in sooty mangabeys naturally infected with simian immunodeficiency virus: implications for AIDS pathogenesis. Journal of Virology. 82: 3725-35. PMID 18216113 DOI: 10.1128/Jvi.02408-07  0.486
2008 Kaur A, Di Mascio M, Barabasz A, Rosenzweig M, McClure HM, Perelson AS, Ribeiro RM, Johnson RP. Dynamics of T- and B-lymphocyte turnover in a natural host of simian immunodeficiency virus. Journal of Virology. 82: 1084-93. PMID 18032490 DOI: 10.1128/Jvi.02197-07  0.591
2008 Perelson AS, Ribeiro RM. Estimating drug efficacy and viral dynamic parameters: HIV and HCV. Statistics in Medicine. 27: 4647-57. PMID 17960579 DOI: 10.1002/Sim.3116  0.67
2007 Chen HY, Di Mascio M, Perelson AS, Ho DD, Zhang L. Determination of virus burst size in vivo using a single-cycle SIV in rhesus macaques Proceedings of the National Academy of Sciences of the United States of America. 104: 19079-19084. PMID 18025463 DOI: 10.1073/pnas.0707449104  0.479
2007 Lau GK, Cooksley H, Ribeiro RM, Powers KA, Shudo E, Bowden S, Hui CK, Anderson J, Sorbel J, Mondou E, Rousseau F, Lewin S, Perelson AS, Locornini S, Naoumov NV. Impact of early viral kinetics on T-cell reactivity during antiviral therapy in chronic hepatitis B. Antiviral Therapy. 12: 705-18. PMID 17713154  0.595
2007 Pandrea IV, Gautam R, Ribeiro RM, Brenchley JM, Butler IF, Pattison M, Rasmussen T, Marx PA, Silvestri G, Lackner AA, Perelson AS, Douek DC, Veazey RS, Apetrei C. Acute loss of intestinal CD4+ T cells is not predictive of simian immunodeficiency virus virulence. Journal of Immunology (Baltimore, Md. : 1950). 179: 3035-46. PMID 17709518 DOI: 10.4049/Jimmunol.179.5.3035  0.626
2007 Dahari H, Ribeiro RM, Perelson AS. Triphasic decline of hepatitis C virus RNA during antiviral therapy. Hepatology (Baltimore, Md.). 46: 16-21. PMID 17596864 DOI: 10.1002/Hep.21657  0.665
2007 Dahari H, Perelson AS. Hepatitis C virus RNA kinetics: drug efficacy and the rate of HCV-infected cells loss. World Journal of Gastroenterology. 13: 3020-1. PMID 17589958 DOI: 10.3748/wjg.v13.i21.3020  0.392
2007 Rong L, Gilchrist MA, Feng Z, Perelson AS. Modeling within-host HIV-1 dynamics and the evolution of drug resistance: trade-offs between viral enzyme function and drug susceptibility. Journal of Theoretical Biology. 247: 804-18. PMID 17532343 DOI: 10.1016/J.Jtbi.2007.04.014  0.348
2007 Jones LE, Perelson AS. Transient viremia, plasma viral load, and reservoir replenishment in HIV-infected patients on antiretroviral therapy. Journal of Acquired Immune Deficiency Syndromes (1999). 45: 483-93. PMID 17496565 DOI: 10.1097/QAI.0b013e3180654836  0.426
2007 Perelson AS, Layden TJ. Ribavirin: is it a mutagen for hepatitis C virus? Gastroenterology. 132: 2050-2. PMID 17484896 DOI: 10.1053/j.gastro.2007.03.077  0.311
2007 Dahari H, Lo A, Ribeiro RM, Perelson AS. Modeling hepatitis C virus dynamics: liver regeneration and critical drug efficacy. Journal of Theoretical Biology. 247: 371-81. PMID 17451750 DOI: 10.1016/J.Jtbi.2007.03.006  0.622
2007 Ciupe SM, Ribeiro RM, Nelson PW, Perelson AS. Modeling the mechanisms of acute hepatitis B virus infection. Journal of Theoretical Biology. 247: 23-35. PMID 17428501 DOI: 10.1016/J.Jtbi.2007.02.017  0.669
2007 Dahari H, Markatou M, Zeremski M, Haller I, Ribeiro RM, Licholai T, Perelson AS, Talal AH. Early ribavirin pharmacokinetics, HCV RNA and alanine aminotransferase kinetics in HIV/HCV co-infected patients during treatment with pegylated interferon and ribavirin. Journal of Hepatology. 47: 23-30. PMID 17412448 DOI: 10.1016/J.Jhep.2007.01.027  0.631
2007 Davenport MP, Ribeiro RM, Zhang L, Wilson DP, Perelson AS. Understanding the mechanisms and limitations of immune control of HIV. Immunological Reviews. 216: 164-75. PMID 17367342 DOI: 10.1111/J.1600-065X.2006.00485.X  0.652
2007 Ribeiro RM, Perelson AS. Determining thymic output quantitatively: using models to interpret experimental T-cell receptor excision circle (TREC) data. Immunological Reviews. 216: 21-34. PMID 17367332 DOI: 10.1111/J.1600-065X.2006.00493.X  0.59
2007 Ciupe SM, Ribeiro RM, Nelson PW, Dusheiko G, Perelson AS. The role of cells refractory to productive infection in acute hepatitis B viral dynamics. Proceedings of the National Academy of Sciences of the United States of America. 104: 5050-5. PMID 17360406 DOI: 10.1073/Pnas.0603626104  0.665
2007 Dahari H, Ribeiro RM, Rice CM, Perelson AS. Mathematical modeling of subgenomic hepatitis C virus replication in Huh-7 cells. Journal of Virology. 81: 750-60. PMID 17035310 DOI: 10.1128/Jvi.01304-06  0.567
2006 Kim H, Perelson AS. Dynamic characteristics of HIV-1 reservoirs. Current Opinion in Hiv and Aids. 1: 152-6. PMID 19372800 DOI: 10.1097/01.Coh.0000203836.08974.96  0.362
2006 Kim H, Perelson AS. Viral and latent reservoir persistence in HIV-1-infected patients on therapy. Plos Computational Biology. 2: e135. PMID 17040122 DOI: 10.1371/Journal.Pcbi.0020135  0.476
2006 Baccam P, Beauchemin C, Macken CA, Hayden FG, Perelson AS. Kinetics of influenza A virus infection in humans. Journal of Virology. 80: 7590-9. PMID 16840338 DOI: 10.1128/Jvi.01623-05  0.44
2006 Talal AH, Ribeiro RM, Powers KA, Grace M, Cullen C, Hussain M, Markatou M, Perelson AS. Pharmacodynamics of PEG-IFN alpha differentiate HIV/HCV coinfected sustained virological responders from nonresponders. Hepatology (Baltimore, Md.). 43: 943-53. PMID 16761329 DOI: 10.1002/Hep.21136  0.569
2006 Davenport MP, Zhang L, Shiver JW, Casmiro DR, Ribeiro RM, Perelson AS. Influence of peak viral load on the extent of CD4+ T-cell depletion in simian HIV infection. Journal of Acquired Immune Deficiency Syndromes (1999). 41: 259-65. PMID 16540926 DOI: 10.1097/01.Qai.0000199232.31340.D3  0.627
2006 Powers KA, Ribeiro RM, Patel K, Pianko S, Nyberg L, Pockros P, Conrad AJ, McHutchison J, Perelson AS. Kinetics of hepatitis C virus reinfection after liver transplantation. Liver Transplantation : Official Publication of the American Association For the Study of Liver Diseases and the International Liver Transplantation Society. 12: 207-16. PMID 16447184 DOI: 10.1002/Lt.20572  0.612
2006 Ribeiro RM, Hazenberg MD, Perelson AS, Davenport MP. Naïve and memory cell turnover as drivers of CCR5-to-CXCR4 tropism switch in human immunodeficiency virus type 1: implications for therapy. Journal of Virology. 80: 802-9. PMID 16378982 DOI: 10.1128/Jvi.80.2.802-809.2006  0.613
2005 Perelson AS, Herrmann E, Micol F, Zeuzem S. New kinetic models for the hepatitis C virus. Hepatology (Baltimore, Md.). 42: 749-54. PMID 16175615 DOI: 10.1002/hep.20882  0.377
2005 Layden-Almer JE, Kuiken C, Ribeiro RM, Kunstman KJ, Perelson AS, Layden TJ, Wolinsky SM. Hepatitis C virus genotype 1a NS5A pretreatment sequence variation and viral kinetics in African American and white patients. The Journal of Infectious Diseases. 192: 1078-87. PMID 16107963 DOI: 10.1086/432760  0.59
2005 Perelson AS, Ribeiro RM. Mutagenic effects of ribavirin in vivo. Journal of Hepatology. 43: 553-5. PMID 16099528 DOI: 10.1016/J.Jhep.2005.07.003  0.589
2005 Jones LE, Perelson AS. Opportunistic infection as a cause of transient viremia in chronically infected HIV patients under treatment with HAART. Bulletin of Mathematical Biology. 67: 1227-51. PMID 16023709 DOI: 10.1016/j.bulm.2005.01.006  0.424
2005 Davenport MP, Zhang L, Bagchi A, Fridman A, Fu TM, Schleif W, Shiver JW, Ribeiro RM, Perelson AS. High-potency human immunodeficiency virus vaccination leads to delayed and reduced CD8+ T-cell expansion but improved virus control. Journal of Virology. 79: 10059-62. PMID 16014966 DOI: 10.1128/Jvi.79.15.10059-10062.2005  0.586
2005 Wu H, Huang Y, Acosta EP, Rosenkranz SL, Kuritzkes DR, Eron JJ, Perelson AS, Gerber JG. Modeling long-term HIV dynamics and antiretroviral response: effects of drug potency, pharmacokinetics, adherence, and drug resistance. Journal of Acquired Immune Deficiency Syndromes (1999). 39: 272-83. PMID 15980686 DOI: 10.1097/01.Qai.0000165907.04710.Da  0.346
2005 Dixit NM, Perelson AS. HIV dynamics with multiple infections of target cells. Proceedings of the National Academy of Sciences of the United States of America. 102: 8198-203. PMID 15928092 DOI: 10.1073/Pnas.0407498102  0.433
2005 Di Mascio M, Percus JK, Percus OE, Markowitz M, Ho DD, Perelson AS. Duration of an intermittent episode of viremia. Bulletin of Mathematical Biology. 67: 885-900. PMID 15893558 DOI: 10.1016/J.Bulm.2004.11.003  0.349
2005 Dahari H, Major M, Zhang X, Mihalik K, Rice CM, Perelson AS, Feinstone SM, Neumann AU. Mathematical modeling of primary hepatitis C infection: Noncytolytic clearance and early blockage of virion production Gastroenterology. 128: 1056-1066. PMID 15825086 DOI: 10.1053/J.Gastro.2005.01.049  0.486
2005 Speirs C, van Nimwegen E, Bolton D, Zavolan M, Duvall M, Angleman S, Siegel R, Perelson AS, Lenardo MJ. Analysis of human immunodeficiency virus cytopathicity by using a new method for quantitating viral dynamics in cell culture. Journal of Virology. 79: 4025-32. PMID 15767404 DOI: 10.1128/JVI.79.7.4025-4032.2005  0.383
2005 Arron ST, Ribeiro RM, Gettie A, Bohm R, Blanchard J, Yu J, Perelson AS, Ho DD, Zhang L. Impact of thymectomy on the peripheral T cell pool in rhesus macaques before and after infection with simian immunodeficiency virus. European Journal of Immunology. 35: 46-55. PMID 15593297 DOI: 10.1002/Eji.200424996  0.586
2004 Nelson PW, Gilchrist MA, Coombs D, Hyman JM, Perelson AS. An age-structured model of hiv infection that allows for variations in the production rate of viral particles and the death rate of productively infected cells. Mathematical Biosciences and Engineering : Mbe. 1: 267-88. PMID 20369971 DOI: 10.3934/Mbe.2004.1.267  0.417
2004 Dixit NM, Layden-Almer JE, Layden TJ, Perelson AS. Modelling how ribavirin improves interferon response rates in hepatitis C virus infection. Nature. 432: 922-4. PMID 15602565 DOI: 10.1038/Nature03153  0.372
2004 Davenport MP, Ribeiro RM, Chao DL, Perelson AS. Predicting the impact of a nonsterilizing vaccine against human immunodeficiency virus. Journal of Virology. 78: 11340-51. PMID 15452255 DOI: 10.1128/Jvi.78.20.11340-11351.2004  0.535
2004 Di Mascio M, Markowitz M, Louie M, Hurley A, Hogan C, Simon V, Follmann D, Ho DD, Perelson AS. Dynamics of intermittent viremia during highly active antiretroviral therapy in patients who initiate therapy during chronic versus acute and early human immunodeficiency virus type 1 infection Journal of Virology. 78: 10566-10573. PMID 15367623 DOI: 10.1128/JVI.78.19.10566-10573.2004  0.44
2004 Davenport MP, Ribeiro RM, Perelson AS. Kinetics of virus-specific CD8+ T cells and the control of human immunodeficiency virus infection. Journal of Virology. 78: 10096-103. PMID 15331742 DOI: 10.1128/Jvi.78.18.10096-10103.2004  0.666
2004 Dixit NM, Perelson AS. Multiplicity of human immunodeficiency virus infections in lymphoid tissue. Journal of Virology. 78: 8942-5. PMID 15280505 DOI: 10.1128/Jvi.78.16.8942-8945.2004  0.409
2004 Perelson AS, Ribeiro RM. Hepatitis B virus kinetics and mathematical modeling. Seminars in Liver Disease. 24: 11-6. PMID 15192796 DOI: 10.1055/S-2004-828673  0.625
2004 Dixit NM, Markowitz M, Ho DD, Perelson AS. Estimates of intracellular delay and average drug efficacy from viral load data of HIV-infected individuals under antiretroviral therapy. Antiviral Therapy. 9: 237-46. PMID 15134186  0.364
2004 Zhang L, Ribeiro RM, Mascola JR, Lewis MG, Stiegler G, Katinger H, Perelson AS, Davenport MP. Effects of antibody on viral kinetics in simian/human immunodeficiency virus infection: implications for vaccination. Journal of Virology. 78: 5520-2. PMID 15113932 DOI: 10.1128/Jvi.78.10.5520-5522.2004  0.645
2004 Chao DL, Davenport MP, Forrest S, Perelson AS. A stochastic model of cytotoxic T cell responses. Journal of Theoretical Biology. 228: 227-40. PMID 15094017 DOI: 10.1016/J.Jtbi.2003.12.011  0.338
2004 Elson K, Ribeiro RM, Perelson AS, Simmons A, Speck P. The life span of ganglionic glia in murine sensory ganglia estimated by uptake of bromodeoxyuridine. Experimental Neurology. 186: 99-103. PMID 14980814 DOI: 10.1016/J.Expneurol.2003.10.017  0.486
2004 Di Mascio M, Ribeiro RM, Markowitz M, Ho DD, Perelson AS. Modeling the long-term control of viremia in HIV-1 infected patients treated with antiretroviral therapy. Mathematical Biosciences. 188: 47-62. PMID 14766093 DOI: 10.1016/J.Mbs.2003.08.003  0.608
2004 Talal AH, Shata MT, Markatou M, Dorante G, Chadburn A, Koch R, Neumann AU, Ribeiro RM, Perelson AS. Virus dynamics and immune responses during treatment in patients coinfected with hepatitis C and HIV. Journal of Acquired Immune Deficiency Syndromes (1999). 35: 103-13. PMID 14722440 DOI: 10.1097/00126334-200402010-00001  0.65
2004 Ramratnam B, Ribeiro R, He T, Chung C, Simon V, Vanderhoeven J, Hurley A, Zhang L, Perelson AS, Ho DD, Markowitz M. Intensification of Antiretroviral Therapy Accelerates the Decay of the HIV-1 Latent Reservoir and Decreases, but Does Not Eliminate, Ongoing Virus Replication Journal of Acquired Immune Deficiency Syndromes. 35: 33-37. PMID 14707789 DOI: 10.1097/00126334-200401010-00004  0.613
2004 Dixit NM, Perelson AS. Complex patterns of viral load decay under antiretroviral therapy: influence of pharmacokinetics and intracellular delay. Journal of Theoretical Biology. 226: 95-109. PMID 14637059 DOI: 10.1016/J.Jtbi.2003.09.002  0.308
2003 Hlavacek WS, Faeder JR, Blinov ML, Perelson AS, Goldstein B. The complexity of complexes in signal transduction. Biotechnology and Bioengineering. 84: 783-94. PMID 14708119 DOI: 10.1002/Bit.10842  0.494
2003 Torriani FJ, Ribeiro RM, Gilbert TL, Schrenk UM, Clauson M, Pacheco DM, Perelson AS. Hepatitis C virus (HCV) and human immunodeficiency virus (HIV) dynamics during HCV treatment in HCV/HIV coinfection. The Journal of Infectious Diseases. 188: 1498-507. PMID 14624375 DOI: 10.1086/379255  0.619
2003 Coombs D, Gilchrist MA, Percus J, Perelson AS. Optimal viral production. Bulletin of Mathematical Biology. 65: 1003-23. PMID 14607286 DOI: 10.1016/S0092-8240(03)00056-9  0.324
2003 Di Mascio M, Markowitz M, Louie M, Hogan C, Hurley A, Chung C, Ho DD, Perelson AS. Viral Blip Dynamics during Highly Active Antiretroviral Therapy Journal of Virology. 77: 12165-12172. PMID 14581553 DOI: 10.1128/JVI.77.22.12165-12172.2003  0.356
2003 Powers KA, Dixit NM, Ribeiro RM, Golia P, Talal AH, Perelson AS. Modeling viral and drug kinetics: hepatitis C virus treatment with pegylated interferon alfa-2b. Seminars in Liver Disease. 23: 13-8. PMID 12934163 DOI: 10.1055/S-2003-41630  0.634
2003 Ribeiro RM, Layden-Almer J, Powers KA, Layden TJ, Perelson AS. Dynamics of alanine aminotransferase during hepatitis C virus treatment. Hepatology (Baltimore, Md.). 38: 509-17. PMID 12883496 DOI: 10.1053/Jhep.2003.50344  0.597
2003 Fan X, Lang DM, Xu Y, Lyra AC, Yusim K, Everhart JE, Korber BT, Perelson AS, Di Bisceglie AM. Liver transplantation with hepatitis C virus-infected graft: interaction between donor and recipient viral strains. Hepatology (Baltimore, Md.). 38: 25-33. PMID 12829983 DOI: 10.1053/jhep.2003.50264  0.321
2003 Louie M, Hogan C, Hurley A, Simon V, Chung C, Padte N, Lamy P, Flaherty J, Coakley D, Di Mascio M, Perelson AS, Markowitz M. Determining the antiviral activity of tenofovir disoproxil fumarate in treatment-naive chronically HIV-1-infected individuals Aids. 17: 1151-1156. PMID 12819516 DOI: 10.1097/00002030-200305230-00006  0.325
2003 Layden-Almer JE, Ribeiro RM, Wiley T, Perelson AS, Layden TJ. Viral dynamics and response differences in HCV-infected African American and white patients treated with IFN and ribavirin. Hepatology (Baltimore, Md.). 37: 1343-50. PMID 12774013 DOI: 10.1053/Jhep.2003.50217  0.643
2003 Layden TJ, Layden JE, Ribeiro RM, Perelson AS. Mathematical modeling of viral kinetics: a tool to understand and optimize therapy. Clinics in Liver Disease. 7: 163-78. PMID 12691465 DOI: 10.1016/S1089-3261(02)00063-6  0.655
2003 Percus JK, Percus OE, Markowitz M, Ho DD, Di Mascio M, Perelson AS. The distribution of viral blips observed in HIV-1 infected patients treated with combination antiretroviral therapy. Bulletin of Mathematical Biology. 65: 263-77. PMID 12675332 DOI: 10.1016/S0092-8240(02)00095-2  0.375
2003 Markowitz M, Louie M, Hurley A, Sun E, Di Mascio M, Perelson AS, Ho DD. A novel antiviral intervention results in more accurate assessment of human immunodeficiency virus type 1 replication dynamics and T-cell decay in vivo Journal of Virology. 77: 5037-5038. PMID 12663814 DOI: 10.1128/JVI.77.8.5037-5038.2003  0.365
2003 Di Mascio M, Dornadula G, Zhang H, Sullivan J, Xu Y, Kulkosky J, Pomerantz RJ, Perelson AS. In a subset of subjects on highly active antiretroviral therapy, human immunodeficiency virus type 1 RNA in plasma decays from 50 to <5 copies per milliliter, with a half-life of 6 months. Journal of Virology. 77: 2271-5. PMID 12525664 DOI: 10.1128/jvi.77.3.2271-2275.2003  0.363
2002 Jones LE, Perelson AS. Modeling the effects of vaccination on chronically infected HIV-positive patients. Journal of Acquired Immune Deficiency Syndromes (1999). 31: 369-77. PMID 12447006  0.381
2002 Ribeiro RM, Mohri H, Ho DD, Perelson AS. In vivo dynamics of T cell activation, proliferation, and death in HIV-1 infection: why are CD4+ but not CD8+ T cells depleted? Proceedings of the National Academy of Sciences of the United States of America. 99: 15572-7. PMID 12434018 DOI: 10.1073/Pnas.242358099  0.565
2002 Lewin SR, Ribeiro RM, Kaufmann GR, Smith D, Zaunders J, Law M, Solomon A, Cameron PU, Cooper D, Perelson AS. Dynamics of T cells and TCR excision circles differ after treatment of acute and chronic HIV infection. Journal of Immunology (Baltimore, Md. : 1950). 169: 4657-66. PMID 12370406 DOI: 10.4049/Jimmunol.169.8.4657  0.593
2002 Ribeiro RM, Lo A, Perelson AS. Dynamics of hepatitis B virus infection. Microbes and Infection / Institut Pasteur. 4: 829-35. PMID 12270730 DOI: 10.1016/S1286-4579(02)01603-9  0.675
2002 Markowitz M, Jin X, Hurley A, Simon V, Ramratnam B, Louie M, Deschenes GR, Ramanathan M, Barsoum S, Vanderhoeven J, He T, Chung C, Murray J, Perelson AS, Zhang L, et al. Discontinuation of antiretroviral therapy commenced early during the course of human immunodeficiency virus type 1 infection, with or without adjunctive vaccination Journal of Infectious Diseases. 186: 634-643. PMID 12195350 DOI: 10.1086/342559  0.352
2002 Ribeiro RM, Perelson AS. Hepatitis B virus viral dynamics: effects of drug dose and baseline alanine aminotransferase. Journal of Hepatology. 37: 277-9. PMID 12127436 DOI: 10.1016/S0168-8278(02)00210-6  0.697
2002 Nelson PW, Perelson AS. Mathematical analysis of delay differential equation models of HIV-1 infection. Mathematical Biosciences. 179: 73-94. PMID 12047922 DOI: 10.1016/S0025-5564(02)00099-8  0.34
2002 Ribeiro RM, Mohri H, Ho DD, Perelson AS. Modeling deuterated glucose labeling of T-lymphocytes. Bulletin of Mathematical Biology. 64: 385-405. PMID 11926122 DOI: 10.1006/Bulm.2001.0282  0.621
2002 Hlavacek WS, Percus JK, Percus OE, Perelson AS, Wofsy C. Retention of antigen on follicular dendritic cells and B lymphocytes through complement-mediated multivalent ligand-receptor interactions: theory and application to HIV treatment. Mathematical Biosciences. 176: 185-202. PMID 11916508 DOI: 10.1016/S0025-5564(02)00091-3  0.644
2002 Perelson AS. Modelling viral and immune system dynamics. Nature Reviews. Immunology. 2: 28-36. PMID 11905835 DOI: 10.1038/nri700  0.432
2002 Callaway DS, Perelson AS. HIV-1 infection and low steady state viral loads. Bulletin of Mathematical Biology. 64: 29-64. PMID 11868336 DOI: 10.1006/bulm.2001.0266  0.445
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