John M. Sedivy - Publications

Affiliations: 
Molecular Biology, Cell Biology and Biochemistry Brown University, Providence, RI 
Website:
http://www.brown.edu/Divisions/Medical_School/biomed/Faculty/S/SedivyJ.html

132 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2022 Taylor JR, Wood JG, Mizerak E, Hinthorn S, Liu J, Finn M, Gordon S, Zingas L, Chang C, Klein MA, Denu JM, Gorbunova V, Seluanov A, Boeke JD, Sedivy JM, et al. Sirt6 regulates lifespan in . Proceedings of the National Academy of Sciences of the United States of America. 119. PMID 35091469 DOI: 10.1073/pnas.2111176119  0.301
2019 Gorgoulis V, Adams PD, Alimonti A, Bennett DC, Bischof O, Bishop C, Campisi J, Collado M, Evangelou K, Ferbeyre G, Gil J, Hara E, Krizhanovsky V, Jurk D, Maier AB, ... ... Sedivy J, et al. Cellular Senescence: Defining a Path Forward. Cell. 179: 813-827. PMID 31675495 DOI: 10.1016/J.Cell.2019.10.005  0.401
2019 Zhao X, Petrashen AP, Sanders JA, Peterson AL, Sedivy JM. SLC1A5 glutamine transporter is a target of MYC and mediates reduced mTORC1 signaling and increased fatty acid oxidation in long-lived Myc hypomorphic mice. Aging Cell. e12947. PMID 30909319 DOI: 10.1111/Acel.12947  0.403
2018 Ito T, Teo YV, Evans SA, Neretti N, Sedivy JM. Regulation of Cellular Senescence by Polycomb Chromatin Modifiers through Distinct DNA Damage- and Histone Methylation-Dependent Pathways. Cell Reports. 22: 3480-3492. PMID 29590617 DOI: 10.1016/J.Celrep.2018.03.002  0.419
2016 Sarosiek KA, Fraser C, Muthalagu N, Bhola PD, Chang W, McBrayer SK, Cantlon A, Fisch S, Golomb-Mello G, Ryan JA, Deng J, Jian B, Corbett C, Goldenberg M, Madsen JR, ... ... Sedivy J, et al. Developmental Regulation of Mitochondrial Apoptosis by c-Myc Governs Age- and Tissue-Specific Sensitivity to Cancer Therapeutics. Cancer Cell. PMID 28017613 DOI: 10.1016/J.Ccell.2016.11.011  0.367
2016 Bacalini MG, Deelen J, Pirazzini C, De Cecco M, Giuliani C, Lanzarini C, Ravaioli F, Marasco E, van Heemst D, Suchiman HE, Slieker R, Giampieri E, Recchioni R, Mercheselli F, Salvioli S, ... ... Sedivy JM, et al. Systemic Age-Associated DNA Hypermethylation of ELOVL2 Gene: In Vivo and In Vitro Evidences of a Cell Replication Process. The Journals of Gerontology. Series a, Biological Sciences and Medical Sciences. PMID 27672102 DOI: 10.1093/Gerona/Glw185  0.343
2016 Criscione SW, De Cecco M, Siranosian B, Zhang Y, Kreiling JA, Sedivy JM, Neretti N. Reorganization of chromosome architecture in replicative cellular senescence. Science Advances. 2: e1500882. PMID 26989773 DOI: 10.1126/Sciadv.1500882  0.36
2016 Gravina S, Sedivy JM, Vijg J. The dark side of circulating nucleic acids. Aging Cell. PMID 26910468 DOI: 10.1111/Acel.12454  0.382
2016 Waaijer ME, Croco E, Westendorp RG, Slagboom PE, Sedivy JM, Lorenzini A, Maier AB. DNA damage markers in dermal fibroblasts in vitro reflect chronological donor age. Aging. PMID 26830451 DOI: 10.18632/Aging.100890  0.302
2016 Borghesan M, Fusilli C, Rappa F, Panebianco C, Rizzo G, Oben JA, Mazzoccoli G, Faulkes C, Pata I, Agodi A, Rezaee F, Minogue S, Warren A, Peterson A, Sedivy JM, et al. DNA Hypomethylation and Histone Variant macroH2A1 Synergistically Attenuate Chemotherapy-Induced Senescence to Promote Hepatocellular Carcinoma Progression. Cancer Research. PMID 26772755 DOI: 10.1158/0008-5472.Can-15-1336  0.342
2016 Kumari A, Iwasaki T, Folk WP, Abdulovic-Cui AL, Pyndiah S, Prendergast GC, Sedivy JM, Sakamuro D. Abstract PR09: c-MYC preserves genomic integrity during DNA replication: a paradigm shift of c-MYC Molecular Cancer Research. 14. DOI: 10.1158/1557-3125.Cellcycle16-Pr09  0.431
2015 Hofmann JW, Zhao X, De Cecco M, Peterson AL, Pagliaroli L, Manivannan J, Hubbard GB, Ikeno Y, Zhang Y, Feng B, Li X, Serre T, Qi W, Van Remmen H, Miller RA, ... ... Sedivy JM, et al. Reduced expression of MYC increases longevity and enhances healthspan. Cell. 160: 477-88. PMID 25619689 DOI: 10.1016/J.Cell.2014.12.016  0.385
2015 Sedivy JM. Abstract IA20: Reduced expression of MYC increases longevity and enhances healthspan Molecular Cancer Research. 13. DOI: 10.1158/1557-3125.Myc15-Ia20  0.386
2014 Nelson DM, McBryan T, Jeyapalan JC, Sedivy JM, Adams PD. A comparison of oncogene-induced senescence and replicative senescence: implications for tumor suppression and aging. Age (Dordrecht, Netherlands). 36: 9637. PMID 24647599 DOI: 10.1007/S11357-014-9637-0  0.394
2014 Hofmann JW, McBryan T, Adams PD, Sedivy JM. The effects of aging on the expression of Wnt pathway genes in mouse tissues. Age (Dordrecht, Netherlands). 36: 9618. PMID 24488586 DOI: 10.1007/S11357-014-9618-3  0.374
2014 Adams P, Antebi A, Cuervo AM, Kennedy B, Sedivy J. Aging Cell: open access to all. Aging Cell. 13: 1. PMID 24433409 DOI: 10.1111/Acel.12187  0.336
2013 Sedivy JM, Kreiling JA, Neretti N, De Cecco M, Criscione SW, Hofmann JW, Zhao X, Ito T, Peterson AL. Death by transposition - the enemy within? Bioessays : News and Reviews in Molecular, Cellular and Developmental Biology. 35: 1035-43. PMID 24129940 DOI: 10.1002/Bies.201300097  0.308
2013 Baker DJ, Sedivy JM. Probing the depths of cellular senescence. The Journal of Cell Biology. 202: 11-3. PMID 23816622 DOI: 10.1083/Jcb.201305155  0.409
2013 De Cecco M, Criscione SW, Peckham EJ, Hillenmeyer S, Hamm EA, Manivannan J, Peterson AL, Kreiling JA, Neretti N, Sedivy JM. Genomes of replicatively senescent cells undergo global epigenetic changes leading to gene silencing and activation of transposable elements. Aging Cell. 12: 247-56. PMID 23360310 DOI: 10.1111/Acel.12047  0.4
2013 Adams P, Antebi A, Cuervo AM, Kennedy B, Sedivy J. Aging Cell Prize for Best Paper 2012 Aging Cell. 12: 1148-1148. DOI: 10.1111/Acel.12162  0.338
2012 Waaijer ME, Parish WE, Strongitharm BH, van Heemst D, Slagboom PE, de Craen AJ, Sedivy JM, Westendorp RG, Gunn DA, Maier AB. The number of p16INK4a positive cells in human skin reflects biological age. Aging Cell. 11: 722-5. PMID 22612594 DOI: 10.1111/J.1474-9726.2012.00837.X  0.337
2012 Sanders JA, Schorl C, Patel A, Sedivy JM, Gruppuso PA. Postnatal liver growth and regeneration are independent of c-myc in a mouse model of conditional hepatic c-myc deletion. Bmc Physiology. 12: 1. PMID 22397685 DOI: 10.1186/1472-6793-12-1  0.357
2012 Zwolinska AK, Heagle Whiting A, Beekman C, Sedivy JM, Marine JC. Suppression of Myc oncogenic activity by nucleostemin haploinsufficiency. Oncogene. 31: 3311-21. PMID 22081066 DOI: 10.1038/Onc.2011.507  0.508
2011 Sedivy JM. Phosphatidylenthanolamine Binding Protein aka Raf Kinase Inhibitor Protein: A Brief History of Its Discovery and the Remarkable Diversity of Biological Functions. Forum On Immunopathological Diseases and Therapeutics. 2: 1-12. PMID 23227430 DOI: 10.1615/Forumimmundisther.V2.I1.20  0.302
2011 Yap CS, Peterson AL, Castellani G, Sedivy JM, Neretti N. Kinetic profiling of the c-Myc transcriptome and bioinformatic analysis of repressed gene promoters. Cell Cycle (Georgetown, Tex.). 10: 2184-96. PMID 21623162 DOI: 10.4161/Cc.10.13.16249  0.483
2011 Kreiling JA, Tamamori-Adachi M, Sexton AN, Jeyapalan JC, Munoz-Najar U, Peterson AL, Manivannan J, Rogers ES, Pchelintsev NA, Adams PD, Sedivy JM. Age-associated increase in heterochromatic marks in murine and primate tissues. Aging Cell. 10: 292-304. PMID 21176091 DOI: 10.1111/J.1474-9726.2010.00666.X  0.367
2011 Antebi A, Cuervo AM, Kennedy B, Martin G, Sedivy J. Aging Cell Prize for Best Paper 2010 Aging Cell. 10: 1092-1092. DOI: 10.1111/J.1474-9726.2011.00761.X  0.338
2010 Agrawal P, Yu K, Salomon AR, Sedivy JM. Proteomic profiling of Myc-associated proteins. Cell Cycle (Georgetown, Tex.). 9: 4908-21. PMID 21150319 DOI: 10.4161/Cc.9.24.14199  0.636
2010 Jimenez RH, Lee JS, Francesconi M, Castellani G, Neretti N, Sanders JA, Sedivy J, Gruppuso PA. Regulation of gene expression in hepatic cells by the mammalian Target of Rapamycin (mTOR). Plos One. 5: e9084. PMID 20140209 DOI: 10.1371/Journal.Pone.0009084  0.508
2010 Paul E, Kielbasinski M, Sedivy JM, Murga-Zamalloa C, Khanna H, Klysik JE. Widespread expression of the Supv3L1 mitochondrial RNA helicase in the mouse. Transgenic Research. 19: 691-701. PMID 19937380 DOI: 10.1007/S11248-009-9346-0  0.362
2010 Alves H, Munoz-Najar U, De Wit J, Renard AJ, Hoeijmakers JH, Sedivy JM, Van Blitterswijk C, De Boer J. A link between the accumulation of DNA damage and loss of multi-potency of human mesenchymal stromal cells. Journal of Cellular and Molecular Medicine. 14: 2729-38. PMID 19818093 DOI: 10.1111/J.1582-4934.2009.00931.X  0.325
2010 Antebi A, Cuervo AM, Martin G, Miller R, Sedivy J. Aging Cell Prize for Best Paper 2009 Aging Cell. 9: 650-650. DOI: 10.1111/J.1474-9726.2010.00603.X  0.338
2009 Campisi J, Sedivy J. How does proliferative homeostasis change with age? What causes it and how does it contribute to aging? The Journals of Gerontology. Series a, Biological Sciences and Medical Sciences. 64: 164-6. PMID 19228778 DOI: 10.1093/Gerona/Gln073  0.336
2009 Paul E, Cronan R, Weston PJ, Boekelheide K, Sedivy JM, Lee SY, Wiest DL, Resnick MB, Klysik JE. Disruption of Supv3L1 damages the skin and causes sarcopenia, loss of fat, and death. Mammalian Genome : Official Journal of the International Mammalian Genome Society. 20: 92-108. PMID 19145458 DOI: 10.1007/S00335-008-9168-Z  0.336
2009 Antebi A, Cuervo AM, Miller R, Sedivy J. Aging Cell Prize for Best Paper Aging Cell. 8: 345-345. DOI: 10.1111/J.1474-9726.2009.00500.X  0.338
2008 Acosta JC, Ferrándiz N, Bretones G, Torrano V, Blanco R, Richard C, O'Connell B, Sedivy J, Delgado MD, León J. Myc inhibits p27-induced erythroid differentiation of leukemia cells by repressing erythroid master genes without reversing p27-mediated cell cycle arrest. Molecular and Cellular Biology. 28: 7286-95. PMID 18838534 DOI: 10.1128/Mcb.00752-08  0.733
2008 Liu YC, Li F, Handler J, Huang CR, Xiang Y, Neretti N, Sedivy JM, Zeller KI, Dang CV. Global regulation of nucleotide biosynthetic genes by c-Myc. Plos One. 3: e2722. PMID 18628958 DOI: 10.1371/Journal.Pone.0002722  0.529
2008 Jeyapalan JC, Sedivy JM. Cellular senescence and organismal aging. Mechanisms of Ageing and Development. 129: 467-74. PMID 18502472 DOI: 10.1016/J.Mad.2008.04.001  0.397
2008 Francesconi M, Remondini D, Neretti N, Sedivy JM, Cooper LN, Verondini E, Milanesi L, Castellani G. Reconstructing networks of pathways via significance analysis of their intersections. Bmc Bioinformatics. 9: S9. PMID 18460182 DOI: 10.1186/1471-2105-9-S4-S9  0.307
2008 Morrish F, Neretti N, Sedivy JM, Hockenbery DM. The oncogene c-Myc coordinates regulation of metabolic networks to enable rapid cell cycle entry. Cell Cycle (Georgetown, Tex.). 7: 1054-66. PMID 18414044 DOI: 10.4161/Cc.7.8.5739  0.483
2008 Rath O, Park S, Tang HH, Banfield MJ, Brady RL, Lee YC, Dignam JD, Sedivy JM, Kolch W, Yeung KC. The RKIP (Raf-1 Kinase Inhibitor Protein) conserved pocket binds to the phosphorylated N-region of Raf-1 and inhibits the Raf-1-mediated activated phosphorylation of MEK. Cellular Signalling. 20: 935-41. PMID 18294816 DOI: 10.1016/J.Cellsig.2008.01.012  0.328
2008 Klysik J, Theroux SJ, Sedivy JM, Moffit JS, Boekelheide K. Signaling crossroads: the function of Raf kinase inhibitory protein in cancer, the central nervous system and reproduction. Cellular Signalling. 20: 1-9. PMID 17706925 DOI: 10.1016/J.Cellsig.2007.07.003  0.374
2008 Antebi A, Cuervo AM, Miller R, Sedivy J. Aging Cell manuscripts on the road to PubMed Central: shifting from manual to automatic transmission Aging Cell. 7: 447-447. DOI: 10.1111/J.1474-9726.2008.00405.X  0.328
2008 Sedivy JM, Munoz-Najar UM, Jeyapalan JC, Campisi J. 8 Cellular Senescence: A Link between Tumor Suppression and Organismal Aging? Cold Spring Harbor Monograph Archive. 51: 185-214. DOI: 10.1101/087969824.51.185  0.407
2008 Ferrandiz N, Acosta J, Bretones G, Torrano V, Blanco R, Richard C, O'Conell B, Sedivy J, Delgado M, Leon J. MYC inhibition of p27-induced erythroid differentiation is mediated by the repression of erythroid master genes and uncoupled from its cell cycle promoting activity European Journal of Cancer Supplements. 6: 79-80. DOI: 10.1016/S1359-6349(08)71482-4  0.476
2007 Manley K, Gee GV, Simkevich CP, Sedivy JM, Atwood WJ. Microarray analysis of glial cells resistant to JCV infection suggests a correlation between viral infection and inflammatory cytokine gene expression. Virology. 366: 394-404. PMID 17555786 DOI: 10.1016/J.Virol.2007.05.016  0.358
2007 Moffit JS, Boekelheide K, Sedivy JM, Klysik J. Mice lacking Raf kinase inhibitor protein-1 (RKIP-1) have altered sperm capacitation and reduced reproduction rates with a normal response to testicular injury. Journal of Andrology. 28: 883-90. PMID 17554109 DOI: 10.2164/Jandrol.107.002964  0.341
2007 Sedivy JM. Telomeres limit cancer growth by inducing senescence: long-sought in vivo evidence obtained. Cancer Cell. 11: 389-91. PMID 17482128 DOI: 10.1016/J.Ccr.2007.04.014  0.34
2007 Neretti N, Remondini D, Tatar M, Sedivy JM, Pierini M, Mazzatti D, Powell J, Franceschi C, Castellani GC. Correlation analysis reveals the emergence of coherence in the gene expression dynamics following system perturbation. Bmc Bioinformatics. 8: S16. PMID 17430560 DOI: 10.1186/1471-2105-8-S1-S16  0.371
2007 Theroux S, Pereira M, Casten KS, Burwell RD, Yeung KC, Sedivy JM, Klysik J. Raf kinase inhibitory protein knockout mice: expression in the brain and olfaction deficit. Brain Research Bulletin. 71: 559-67. PMID 17292798 DOI: 10.1016/J.Brainresbull.2006.11.010  0.334
2007 Schorl C, Sedivy JM. Analysis of cell cycle phases and progression in cultured mammalian cells. Methods (San Diego, Calif.). 41: 143-50. PMID 17189856 DOI: 10.1016/J.Ymeth.2006.07.022  0.398
2007 Jeyapalan JC, Ferreira M, Sedivy JM, Herbig U. Accumulation of senescent cells in mitotic tissue of aging primates. Mechanisms of Ageing and Development. 128: 36-44. PMID 17116315 DOI: 10.1016/J.Mad.2006.11.008  0.406
2007 Remondini D, Neretti N, Franceschi C, Tieri P, Sedivy JM, Milanesi L, Castellani GC. Networks from gene expression time series: Characterization of correlation patterns International Journal of Bifurcation and Chaos. 17: 2477-2483. DOI: 10.1142/S0218127407018543  0.361
2006 Guney I, Sedivy JM. Cellular senescence, epigenetic switches and c-Myc. Cell Cycle (Georgetown, Tex.). 5: 2319-23. PMID 17102614 DOI: 10.4161/Cc.5.20.3348  0.725
2006 Lee HC, Tian B, Sedivy JM, Wands JR, Kim M. Loss of Raf kinase inhibitor protein promotes cell proliferation and migration of human hepatoma cells. Gastroenterology. 131: 1208-17. PMID 17030190 DOI: 10.1053/J.Gastro.2006.07.012  0.334
2006 Guney I, Wu S, Sedivy JM. Reduced c-Myc signaling triggers telomere-independent senescence by regulating Bmi-1 and p16(INK4a). Proceedings of the National Academy of Sciences of the United States of America. 103: 3645-50. PMID 16537449 DOI: 10.1073/Pnas.0600069103  0.759
2006 Herbig U, Ferreira M, Condel L, Carey D, Sedivy JM. Cellular senescence in aging primates. Science (New York, N.Y.). 311: 1257. PMID 16456035 DOI: 10.1126/Science.1122446  0.416
2006 Herbig U, Sedivy JM. Regulation of growth arrest in senescence: telomere damage is not the end of the story. Mechanisms of Ageing and Development. 127: 16-24. PMID 16229875 DOI: 10.1016/J.Mad.2005.09.002  0.464
2005 Kujoth GC, Hiona A, Pugh TD, Someya S, Panzer K, Wohlgemuth SE, Hofer T, Seo AY, Sullivan R, Jobling WA, Morrow JD, Van Remmen H, Sedivy JM, Yamasoba T, Tanokura M, et al. Mitochondrial DNA mutations, oxidative stress, and apoptosis in mammalian aging. Science (New York, N.Y.). 309: 481-4. PMID 16020738 DOI: 10.1126/Science.1112125  0.742
2005 Tamura K, Hua B, Adachi S, Guney I, Kawauchi J, Morioka M, Tamamori-Adachi M, Tanaka Y, Nakabeppu Y, Sunamori M, Sedivy JM, Kitajima S. Stress response gene ATF3 is a target of c-myc in serum-induced cell proliferation. The Embo Journal. 24: 2590-601. PMID 15990869 DOI: 10.1038/Sj.Emboj.7600742  0.744
2005 Remondini D, O'Connell B, Intrator N, Sedivy JM, Neretti N, Castellani GC, Cooper LN. Targeting c-Myc-activated genes with a correlation method: detection of global changes in large gene expression network dynamics. Proceedings of the National Academy of Sciences of the United States of America. 102: 6902-6. PMID 15867157 DOI: 10.1073/Pnas.0502081102  0.676
2005 Rothermund K, Rogulski K, Fernandes E, Whiting A, Sedivy J, Pu L, Prochownik EV. C-Myc-independent restoration of multiple phenotypes by two C-Myc target genes with overlapping functions. Cancer Research. 65: 2097-107. PMID 15781619 DOI: 10.1158/0008-5472.Can-04-2928  0.816
2005 Muñoz-Alonso MJ, Acosta JC, Richard C, Delgado MD, Sedivy J, León J. p21Cip1 and p27Kip1 induce distinct cell cycle effects and differentiation programs in myeloid leukemia cells. The Journal of Biological Chemistry. 280: 18120-9. PMID 15746092 DOI: 10.1074/Jbc.M500758200  0.433
2004 Smith KP, Byron M, O'Connell BC, Tam R, Schorl C, Guney I, Hall LL, Agrawal P, Sedivy JM, Lawrence JB. c-Myc localization within the nucleus: evidence for association with the PML nuclear body. Journal of Cellular Biochemistry. 93: 1282-96. PMID 15503302 DOI: 10.1002/Jcb.20273  0.79
2004 Csoka AB, English SB, Simkevich CP, Ginzinger DG, Butte AJ, Schatten GP, Rothman FG, Sedivy JM. Genome-scale expression profiling of Hutchinson-Gilford progeria syndrome reveals widespread transcriptional misregulation leading to mesodermal/mesenchymal defects and accelerated atherosclerosis. Aging Cell. 3: 235-43. PMID 15268757 DOI: 10.1111/J.1474-9728.2004.00105.X  0.409
2004 Charrier-Savournin FB, Château MT, Gire V, Sedivy J, Piette J, Dulic V. p21-Mediated nuclear retention of cyclin B1-Cdk1 in response to genotoxic stress. Molecular Biology of the Cell. 15: 3965-76. PMID 15181148 DOI: 10.1091/Mbc.E03-12-0871  0.431
2004 Herbig U, Jobling WA, Chen BP, Chen DJ, Sedivy JM. Telomere shortening triggers senescence of human cells through a pathway involving ATM, p53, and p21(CIP1), but not p16(INK4a). Molecular Cell. 14: 501-13. PMID 15149599 DOI: 10.1016/S1097-2765(04)00256-4  0.788
2004 Martin-Ruiz C, Saretzki G, Petrie J, Ladhoff J, Jeyapalan J, Wei W, Sedivy J, von Zglinicki T. Stochastic variation in telomere shortening rate causes heterogeneity of human fibroblast replicative life span. The Journal of Biological Chemistry. 279: 17826-33. PMID 14963037 DOI: 10.1074/Jbc.M311980200  0.585
2004 Chatterjee D, Bai Y, Wang Z, Beach S, Mott S, Roy R, Braastad C, Sun Y, Mukhopadhyay A, Aggarwal BB, Darnowski J, Pantazis P, Wyche J, Fu Z, Kitagwa Y, ... ... Sedivy JM, et al. RKIP sensitizes prostate and breast cancer cells to drug-induced apoptosis. The Journal of Biological Chemistry. 279: 17515-23. PMID 14766752 DOI: 10.1074/Jbc.M313816200  0.37
2004 Hindley AD, Park S, Wang L, Shah K, Wang Y, Hu X, Shokat KM, Kolch W, Sedivy JM, Yeung KC. Engineering the serine/threonine protein kinase Raf-1 to utilise an orthogonal analogue of ATP substituted at the N6 position. Febs Letters. 556: 26-34. PMID 14706820 DOI: 10.1016/S0014-5793(03)01352-8  0.32
2003 Ma W, Hommel C, Brenneisen P, Peters T, Smit N, Sedivy J, Scharffetter-Kochanek K, Wlaschek M. Long-term growth arrest of PUVA-treated fibroblasts in G2/M in the absence of p16(INK4a) p21(CIP1) or p53. Experimental Dermatology. 12: 629-37. PMID 14705804 DOI: 10.1034/j.1600-0625.2003.00024.x  0.3
2003 Herbig U, Wei W, Dutriaux A, Jobling WA, Sedivy JM. Real-time imaging of transcriptional activation in live cells reveals rapid up-regulation of the cyclin-dependent kinase inhibitor gene CDKN1A in replicative cellular senescence. Aging Cell. 2: 295-304. PMID 14677632 DOI: 10.1046/J.1474-9728.2003.00067.X  0.801
2003 Wei W, Herbig U, Wei S, Dutriaux A, Sedivy JM. Loss of retinoblastoma but not p16 function allows bypass of replicative senescence in human fibroblasts. Embo Reports. 4: 1061-6. PMID 14566323 DOI: 10.1038/Sj.Embor.7400001  0.706
2003 Collins CJ, Sedivy JM. Involvement of the INK4a/Arf gene locus in senescence. Aging Cell. 2: 145-50. PMID 12882406 DOI: 10.1046/J.1474-9728.2003.00048.X  0.394
2003 Hemmer R, Wei W, Dutriaux A, Sedivy J. Somatic cell knockouts of tumor suppressor genes. Methods in Molecular Biology (Clifton, N.J.). 223: 187-206. PMID 12777730 DOI: 10.1385/1-59259-329-1:187  0.553
2003 Sedivy JM. Reproductive cloning conserves cellular senescence. Nature Cell Biology. 5: 495-6. PMID 12776121 DOI: 10.1038/Ncb0603-495  0.327
2003 Junqueira D, Cilenti L, Musumeci L, Sedivy JM, Zervos AS. Random mutagenesis of PDZ(Omi) domain and selection of mutants that specifically bind the Myc proto-oncogene and induce apoptosis. Oncogene. 22: 2772-81. PMID 12743600 DOI: 10.1038/Sj.Onc.1206359  0.348
2003 Lindvall C, Hou M, Komurasaki T, Zheng C, Henriksson M, Sedivy JM, Björkholm M, Teh BT, Nordenskjöld M, Xu D. Molecular characterization of human telomerase reverse transcriptase-immortalized human fibroblasts by gene expression profiling: activation of the epiregulin gene. Cancer Research. 63: 1743-7. PMID 12702554  0.388
2003 Wei W, Jobling WA, Chen W, Hahn WC, Sedivy JM. Abolition of cyclin-dependent kinase inhibitor p16Ink4a and p21Cip1/Waf1 functions permits Ras-induced anchorage-independent growth in telomerase-immortalized human fibroblasts. Molecular and Cellular Biology. 23: 2859-70. PMID 12665584 DOI: 10.1128/Mcb.23.8.2859-2870.2003  0.776
2003 Young JI, Sedivy JM, Smith JR. Telomerase expression in normal human fibroblasts stabilizes DNA 5-methylcytosine transferase I. The Journal of Biological Chemistry. 278: 19904-8. PMID 12665523 DOI: 10.1074/Jbc.M301685200  0.411
2003 Schorl C, Sedivy JM. Loss of protooncogene c-Myc function impedes G1 phase progression both before and after the restriction point. Molecular Biology of the Cell. 14: 823-35. PMID 12631706 DOI: 10.1091/Mbc.E02-10-0649  0.449
2003 O'Connell BC, Cheung AF, Simkevich CP, Tam W, Ren X, Mateyak MK, Sedivy JM. A large scale genetic analysis of c-Myc-regulated gene expression patterns. The Journal of Biological Chemistry. 278: 12563-73. PMID 12529326 DOI: 10.1074/Jbc.M210462200  0.815
2003 Wei W, Herbig U, Wei S, Dutriaux A, Sedivy JM. Loss of retinoblastoma but not p16 function allows bypass of replicative senescence in human fibroblasts Embo Reports. 4: 1061-1065. DOI: 10.1038/sj.embor.7400001  0.613
2002 Wang Z, Bhattacharya N, Mixter PF, Wei W, Sedivy J, Magnuson NS. Phosphorylation of the cell cycle inhibitor p21Cip1/WAF1 by Pim-1 kinase. Biochimica Et Biophysica Acta. 1593: 45-55. PMID 12431783 DOI: 10.1016/S0167-4889(02)00347-6  0.572
2002 You Z, Madrid LV, Saims D, Sedivy J, Wang CY. c-Myc sensitizes cells to tumor necrosis factor-mediated apoptosis by inhibiting nuclear factor kappa B transactivation. The Journal of Biological Chemistry. 277: 36671-7. PMID 12149248 DOI: 10.1074/Jbc.M203213200  0.417
2002 Nikiforov MA, Chandriani S, O'Connell B, Petrenko O, Kotenko I, Beavis A, Sedivy JM, Cole MD. A functional screen for Myc-responsive genes reveals serine hydroxymethyltransferase, a major source of the one-carbon unit for cell metabolism. Molecular and Cellular Biology. 22: 5793-800. PMID 12138190 DOI: 10.1128/Mcb.22.16.5793-5800.2002  0.714
2002 Obaya AJ, Kotenko I, Cole MD, Sedivy JM. The proto-oncogene c-myc acts through the cyclin-dependent kinase (Cdk) inhibitor p27(Kip1) to facilitate the activation of Cdk4/6 and early G(1) phase progression. The Journal of Biological Chemistry. 277: 31263-9. PMID 12070150 DOI: 10.1074/Jbc.M202528200  0.467
2002 Han Z, Wei W, Dunaway S, Darnowski JW, Calabresi P, Sedivy J, Hendrickson EA, Balan KV, Pantazis P, Wyche JH. Role of p21 in apoptosis and senescence of human colon cancer cells treated with camptothecin. The Journal of Biological Chemistry. 277: 17154-60. PMID 11877436 DOI: 10.1074/Jbc.M112401200  0.591
2002 Obaya AJ, Sedivy JM. Regulation of cyclin-Cdk activity in mammalian cells. Cellular and Molecular Life Sciences : Cmls. 59: 126-42. PMID 11846025 DOI: 10.1007/S00018-002-8410-1  0.439
2002 Raderschall E, Bazarov A, Cao J, Lurz R, Smith A, Mann W, Ropers HH, Sedivy JM, Golub EI, Fritz E, Haaf T. Formation of higher-order nuclear Rad51 structures is functionally linked to p21 expression and protection from DNA damage-induced apoptosis. Journal of Cell Science. 115: 153-64. PMID 11801733  0.306
2001 Yeung KC, Rose DW, Dhillon AS, Yaros D, Gustafsson M, Chatterjee D, McFerran B, Wyche J, Kolch W, Sedivy JM. Raf kinase inhibitor protein interacts with NF-kappaB-inducing kinase and TAK1 and inhibits NF-kappaB activation. Molecular and Cellular Biology. 21: 7207-17. PMID 11585904 DOI: 10.1128/Mcb.21.21.7207-7217.2001  0.325
2001 Wei W, Hemmer RM, Sedivy JM. Role of p14(ARF) in replicative and induced senescence of human fibroblasts. Molecular and Cellular Biology. 21: 6748-57. PMID 11564860 DOI: 10.1128/Mcb.21.20.6748-6757.2001  0.608
2001 Adachi S, Obaya AJ, Han Z, Ramos-Desimone N, Wyche JH, Sedivy JM. c-Myc is necessary for DNA damage-induced apoptosis in the G(2) phase of the cell cycle. Molecular and Cellular Biology. 21: 4929-37. PMID 11438650 DOI: 10.1128/Mcb.21.15.4929-4937.2001  0.489
2001 Soucie EL, Annis MG, Sedivy J, Filmus J, Leber B, Andrews DW, Penn LZ. Myc potentiates apoptosis by stimulating Bax activity at the mitochondria. Molecular and Cellular Biology. 21: 4725-36. PMID 11416148 DOI: 10.1128/Mcb.21.14.4725-4736.2001  0.415
2001 Bowman T, Broome MA, Sinibaldi D, Wharton W, Pledger WJ, Sedivy JM, Irby R, Yeatman T, Courtneidge SA, Jove R. Stat3-mediated Myc expression is required for Src transformation and PDGF-induced mitogenesis. Proceedings of the National Academy of Sciences of the United States of America. 98: 7319-24. PMID 11404481 DOI: 10.1073/Pnas.131568898  0.425
2000 Oster SK, Marhin WW, Asker C, Facchini LM, Dion PA, Funa K, Post M, Sedivy JM, Penn LZ. Myc is an essential negative regulator of platelet-derived growth factor beta receptor expression. Molecular and Cellular Biology. 20: 6768-78. PMID 10958674 DOI: 10.1128/Mcb.20.18.6768-6778.2000  0.385
2000 Landay M, Oster SK, Khosravi F, Grove LE, Yin X, Sedivy J, Penn LZ, Prochownik EV. Promotion of growth and apoptosis in c-myc nullizygous fibroblasts by other members of the myc oncoprotein family. Cell Death and Differentiation. 7: 697-705. PMID 10918443 DOI: 10.1038/Sj.Cdd.4400701  0.497
2000 Yeung K, Janosch P, McFerran B, Rose DW, Mischak H, Sedivy JM, Kolch W. Mechanism of suppression of the Raf/MEK/extracellular signal-regulated kinase pathway by the raf kinase inhibitor protein. Molecular and Cellular Biology. 20: 3079-85. PMID 10757792 DOI: 10.1128/Mcb.20.9.3079-3085.2000  0.334
2000 Hermeking H, Rago C, Schuhmacher M, Li Q, Barrett JF, Obaya AJ, O'Connell BC, Mateyak MK, Tam W, Kohlhuber F, Dang CV, Sedivy JM, Eick D, Vogelstein B, Kinzler KW. Identification of CDK4 as a target of c-MYC. Proceedings of the National Academy of Sciences of the United States of America. 97: 2229-34. PMID 10688915 DOI: 10.1073/Pnas.050586197  0.815
1999 Wei W, Sedivy JM. Differentiation between senescence (M1) and crisis (M2) in human fibroblast cultures. Experimental Cell Research. 253: 519-22. PMID 10585275 DOI: 10.1006/Excr.1999.4665  0.56
1999 Yeung K, Seitz T, Li S, Janosch P, McFerran B, Kaiser C, Fee F, Katsanakis KD, Rose DW, Mischak H, Sedivy JM, Kolch W. Suppression of Raf-1 kinase activity and MAP kinase signalling by RKIP. Nature. 401: 173-7. PMID 10490027 DOI: 10.1038/43686  0.349
1999 Obaya AJ, Mateyak MK, Sedivy JM. Mysterious liaisons: the relationship between c-Myc and the cell cycle. Oncogene. 18: 2934-41. PMID 10378690 DOI: 10.1038/Sj.Onc.1202749  0.792
1999 Mateyak MK, Obaya AJ, Sedivy JM. c-Myc regulates cyclin D-Cdk4 and -Cdk6 activity but affects cell cycle progression at multiple independent points. Molecular and Cellular Biology. 19: 4672-83. PMID 10373516 DOI: 10.1128/Mcb.19.7.4672  0.806
1999 Sedivy JM, Dutriaux A. Gene targeting and somatic cell genetics--a rebirth or a coming of age? Trends in Genetics : Tig. 15: 88-90. PMID 10203800 DOI: 10.1016/S0168-9525(98)01689-8  0.426
1999 Sedivy JM. Gene Targeting in Human Cells Without Isogenic DNA Science. 283: 9a-9. DOI: 10.1126/Science.283.5398.9A  0.393
1998 Xiao Q, Claassen G, Shi J, Adachi S, Sedivy J, Hann SR. Transactivation-defective c-MycS retains the ability to regulate proliferation and apoptosis. Genes & Development. 12: 3803-8. PMID 9869633 DOI: 10.1101/Gad.12.24.3803  0.436
1998 Bush A, Mateyak M, Dugan K, Obaya A, Adachi S, Sedivy J, Cole M. c-myc null cells misregulate cad and gadd45 but not other proposed c-Myc targets. Genes & Development. 12: 3797-802. PMID 9869632 DOI: 10.1101/Gad.12.24.3797  0.793
1998 Counter CM, Hahn WC, Wei W, Caddle SD, Beijersbergen RL, Lansdorp PM, Sedivy JM, Weinberg RA. Dissociation among in vitro telomerase activity, telomere maintenance, and cellular immortalization. Proceedings of the National Academy of Sciences of the United States of America. 95: 14723-8. PMID 9843956 DOI: 10.1073/Pnas.95.25.14723  0.604
1998 Bunz F, Dutriaux A, Lengauer C, Waldman T, Zhou S, Brown JP, Sedivy JM, Kinzler KW, Vogelstein B. Requirement for p53 and p21 to sustain G2 arrest after DNA damage. Science (New York, N.Y.). 282: 1497-501. PMID 9822382 DOI: 10.1126/Science.282.5393.1497  0.416
1998 Sedivy JM. Can ends justify the means?: telomeres and the mechanisms of replicative senescence and immortalization in mammalian cells. Proceedings of the National Academy of Sciences of the United States of America. 95: 9078-81. PMID 9689036 DOI: 10.1073/Pnas.95.16.9078  0.405
1998 Prouty SM, Maroo A, Maucher C, Mischak H, Kolch W, Sedivy JM. Studies of perinuclear and nuclear translocation of the Raf-1 protein in rodent fibroblasts. Biochimica Et Biophysica Acta. 1402: 6-16. PMID 9551081 DOI: 10.1016/S0167-4889(97)00136-5  0.384
1998 Shichiri M, Sedivy JM, Marumo F, Hirata Y. Endothelin-1 is a potent survival factor for c-Myc-dependent apoptosis. Molecular Endocrinology (Baltimore, Md.). 12: 172-80. PMID 9482660 DOI: 10.1210/Mend.12.2.0064  0.447
1997 Shichiri M, Adachi S, Sedivy JM, Marumo F, Hirata Y. Biphasic regulation of the preproendothelin-1 gene by c-myc. Endocrinology. 138: 4584-90. PMID 9348182 DOI: 10.1210/Endo.138.11.5538  0.474
1997 Brown JP, Wei W, Sedivy JM. Bypass of senescence after disruption of p21CIP1/WAF1 gene in normal diploid human fibroblasts. Science (New York, N.Y.). 277: 831-4. PMID 9242615 DOI: 10.1126/Science.277.5327.831  0.652
1997 Weissinger EM, Eissner G, Grammer C, Fackler S, Haefner B, Yoon LS, Lu KS, Bazarov A, Sedivy JM, Mischak H, Kolch W. Inhibition of the Raf-1 kinase by cyclic AMP agonists causes apoptosis of v-abl-transformed cells. Molecular and Cellular Biology. 17: 3229-41. PMID 9154822 DOI: 10.1128/Mcb.17.6.3229  0.408
1997 Brown JP, Wei W, Sedivy JM. Bypass of senescenoe after disruption of p21(CIP1)/(WAF1) gene in normal diploid human fibroblasts Science. 277: 831-834. DOI: 10.1126/science.277.5327.831  0.603
1995 Li S, Janosch P, Tanji M, Rosenfeld GC, Waymire JC, Mischak H, Kolch W, Sedivy JM. Regulation of Raf-1 kinase activity by the 14-3-3 family of proteins. The Embo Journal. 14: 685-96. PMID 7882972 DOI: 10.1002/J.1460-2075.1995.Tb07047.X  0.368
1995 Hanson KD, Sedivy JM. Analysis of biological selections for high-efficiency gene targeting. Molecular and Cellular Biology. 15: 45-51. PMID 7799954 DOI: 10.1128/Mcb.15.1.45  0.368
1995 Yang TA, Heiser WC, Sedivy JM. Efficient in situ electroporation of mammalian cells grown on microporous membranes. Nucleic Acids Research. 23: 2803-10. PMID 7659501 DOI: 10.1093/Nar/23.15.2803  0.356
1994 Hanson KD, Shichiri M, Follansbee MR, Sedivy JM. Effects of c-myc expression on cell cycle progression. Molecular and Cellular Biology. 14: 5748-55. PMID 8065309 DOI: 10.1128/Mcb.14.9.5748  0.421
1993 Shichiri M, Hanson KD, Sedivy JM. Effects of c-myc expression on proliferation, quiescence, and the G0 to G1 transition in nontransformed cells. Cell Growth & Differentiation : the Molecular Biology Journal of the American Association For Cancer Research. 4: 93-104. PMID 8494788  0.393
1993 Prouty SM, Hanson KD, Boyle AL, Brown JR, Shichiri M, Follansbee MR, Kang W, Sedivy JM. A cell culture model system for genetic analyses of the cell cycle by targeted homologous recombination. Oncogene. 8: 899-907. PMID 8455944  0.396
1993 Li S, Sedivy JM. Raf-1 protein kinase activates the NF-kappa B transcription factor by dissociating the cytoplasmic NF-kappa B-I kappa B complex. Proceedings of the National Academy of Sciences of the United States of America. 90: 9247-51. PMID 8415686 DOI: 10.1073/Pnas.90.20.9247  0.331
1993 Karantza V, Maroo A, Fay D, Sedivy JM. Overproduction of Rb protein after the G1/S boundary causes G2 arrest. Molecular and Cellular Biology. 13: 6640-52. PMID 8413260 DOI: 10.1128/Mcb.13.11.6640  0.435
1989 Sedivy JM, Sharp PA. Positive genetic selection for gene disruption in mammalian cells by homologous recombination. Proceedings of the National Academy of Sciences of the United States of America. 86: 227-31. PMID 2536156 DOI: 10.1073/Pnas.86.1.227  0.546
1988 Sedivy JM. New Genetic methods for mammalian cells Bio/Technology. 6: 1192-1196. DOI: 10.1038/Nbt1088-1192  0.377
1987 Sedivy JM, Capone JP, RajBhandary UL, Sharp PA. An inducible mammalian amber suppressor: propagation of a poliovirus mutant. Cell. 50: 379-89. PMID 3038332 DOI: 10.1016/0092-8674(87)90492-2  0.57
1986 Capone JP, Sedivy JM, Sharp PA, RajBhandary UL. Introduction of UAG, UAA, and UGA nonsense mutations at a specific site in the Escherichia coli chloramphenicol acetyltransferase gene: use in measurement of amber, ochre, and opal suppression in mammalian cells. Molecular and Cellular Biology. 6: 3059-67. PMID 3023959 DOI: 10.1128/Mcb.6.9.3059  0.577
1986 Sedivy JM, Babul J, Fraenkel DG. AMP-insensitive fructose bisphosphatase in Escherichia coli and its consequences. Proceedings of the National Academy of Sciences of the United States of America. 83: 1656-9. PMID 3006063 DOI: 10.1073/Pnas.83.6.1656  0.583
1985 Sedivy JM, Fraenkel DG. Fructose bisphosphatase of Saccharomyces cerevisiae. Cloning, disruption and regulation of the FBP1 structural gene. Journal of Molecular Biology. 186: 307-19. PMID 3003364 DOI: 10.1016/0022-2836(85)90107-X  0.647
1984 Sedivy JM, Daldal F, Fraenkel DG. Fructose bisphosphatase of Escherichia coli: cloning of the structural gene (fbp) and preparation of a chromosomal deletion. Journal of Bacteriology. 158: 1048-53. PMID 6327623 DOI: 10.1128/Jb.158.3.1048-1053.1984  0.635
1982 Goldstein R, Sedivy J, Ljungquist E. Propagation of satellite phage P4 as a plasmid. Proceedings of the National Academy of Sciences of the United States of America. 79: 515-9. PMID 7043461 DOI: 10.1073/Pnas.79.2.515  0.342
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