David V. Schaffer, Ph.D. - Publications

Chemistry University of California, Berkeley, Berkeley, CA 
viral gene delivery, stem cells

313 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2021 Öztürk BE, Johnson ME, Kleyman M, Turunç S, He J, Jabalameli S, Xi Z, Visel M, Dufour VL, Iwabe S, Pompeo Marinho F, Aguirre GD, Sahel JA, Schaffer DV, Pfenning AR, et al. scAAVengr, a transcriptome-based pipeline for quantitative ranking of engineered AAVs with single-cell resolution. Elife. 10. PMID 34664552 DOI: 10.7554/eLife.64175  1
2021 Barnes CR, Lee H, Ojala DS, Lewis KK, Limsirichai P, Schaffer DV. Genome-wide activation screens to increase adeno-associated virus production. Molecular Therapy. Nucleic Acids. 26: 94-103. PMID 34513296 DOI: 10.1016/j.omtn.2021.06.026  1
2021 Lei R, Akins EA, Wong KCY, Repina NA, Wolf KJ, Dempsey GE, Schaffer DV, Stahl A, Kumar S. Multiwell Combinatorial Hydrogel Array for High-Throughput Analysis of Cell-ECM Interactions. Acs Biomaterials Science & Engineering. PMID 34028263 DOI: 10.1021/acsbiomaterials.1c00065  1
2021 Zhu D, Schieferecke AJ, Lopez PA, Schaffer DV. Adeno-Associated Virus Vector for Central Nervous System Gene Therapy. Trends in Molecular Medicine. PMID 33895085 DOI: 10.1016/j.molmed.2021.03.010  1
2021 Ramasubramanian A, Muckom R, Sugnaux C, Fuentes C, Ekerdt BL, Clark DS, Healy KE, Schaffer DV. High-Throughput Discovery of Targeted, Minimally Complex Peptide Surfaces for Human Pluripotent Stem Cell Culture. Acs Biomaterials Science & Engineering. PMID 33750112 DOI: 10.1021/acsbiomaterials.0c01462  1
2021 Cabral KA, Patterson DM, Scheideler OJ, Cole R, Abate AR, Schaffer DV, Sohn LL, Gartner ZJ. Simple, Affordable, and Modular Patterning of Cells using DNA. Journal of Visualized Experiments : Jove. PMID 33720126 DOI: 10.3791/61937  1
2020 Muckom RJ, Sampayo RG, Johnson HJ, Schaffer DV. Advanced Materials to Enhance Central Nervous System Tissue Modeling and Cell Therapy. Advanced Functional Materials. 30. PMID 33510596 DOI: 10.1002/Adfm.202002931  1
2020 Repina NA, Johnson HJ, McClave T, Kane RS, Schaffer DV. Protocol to Fabricate Engineered Illumination Devices for Optogenetic Control of Cellular Signaling Dynamics. Star Protocols. 1: 100141. PMID 33377035 DOI: 10.1016/j.xpro.2020.100141  1
2020 Rosenbloom AB, Tarczyński M, Lam N, Kane RS, Bugaj LJ, Schaffer DV. β-Catenin signaling dynamics regulate cell fate in differentiating neural stem cells. Proceedings of the National Academy of Sciences of the United States of America. PMID 33139571 DOI: 10.1073/pnas.2008509117  1
2020 Muckom R, Bao X, Tran E, Chen E, Murugappan A, Dordick JS, Clark DS, Schaffer DV. High-throughput 3D screening for differentiation of hPSC-derived cell therapy candidates. Science Advances. 6: eaaz1457. PMID 32821815 DOI: 10.1126/Sciadv.Aaz1457  1
2020 Carneiro A, Lee HC, Lin L, van Haasteren J, Schaffer D. Novel lung tropic AAV capsids for therapeutic gene delivery. Human Gene Therapy. PMID 32799685 DOI: 10.1089/Hum.2020.169  1
2020 Mukherjee A, Sudrik C, Hu Y, Arha M, Stathos M, Baek J, Schaffer DV, Kane RS. CL6mN: Rationally Designed Optogenetic Photoswitches with Tunable Dissociation Dynamics. Acs Synthetic Biology. PMID 32794731 DOI: 10.1021/Acssynbio.0C00362  1
2020 van Haasteren J, Li J, Scheideler OJ, Murthy N, Schaffer DV. The delivery challenge: fulfilling the promise of therapeutic genome editing. Nature Biotechnology. PMID 32601435 DOI: 10.1038/S41587-020-0565-5  1
2020 Repina NA, McClave T, Johnson HJ, Bao X, Kane RS, Schaffer DV. Engineered Illumination Devices for Optogenetic Control of Cellular Signaling Dynamics. Cell Reports. 31: 107737. PMID 32521262 DOI: 10.1016/J.Celrep.2020.107737  1
2020 Tou CJ, Schaffer DV, Dueber JE. Targeted diversification in the genome with CRISPR-guided DNA polymerase I. Acs Synthetic Biology. PMID 32485105 DOI: 10.1021/Acssynbio.0C00149  0.04
2020 Byrne LC, Day TP, Visel M, Fortuny C, Dalkara D, Merigan WH, Schaffer DV, Flannery JG. In vivo directed evolution of AAV in the primate retina. Jci Insight. PMID 32271719 DOI: 10.1172/Jci.Insight.135112  1
2020 Scheideler OJ, Yang C, Kozminsky M, Mosher KI, Falcón-Banchs R, Ciminelli EC, Bremer AW, Chern SA, Schaffer DV, Sohn LL. Recapitulating complex biological signaling environments using a multiplexed, DNA-patterning approach. Science Advances. 6: eaay5696. PMID 32206713 DOI: 10.1126/Sciadv.Aay5696  1
2020 Mukherjee A, Stathos ME, Varner C, Arsiwala A, Frey S, Hu Y, Smalley DM, Schaffer DV, Kane RS. One-pot synthesis of heterodimeric agonists that activate the canonical Wnt signaling pathway. Chemical Communications (Cambridge, England). PMID 32119023 DOI: 10.1039/D0Cc00920B  1
2020 Kang PH, Schaffer DV, Kumar S. Angiomotin links ROCK and YAP signaling in mechanosensitive differentiation of neural stem cells. Molecular Biology of the Cell. mbcE19110602. PMID 31940260 DOI: 10.1091/Mbc.E19-11-0602  1
2019 Kim SH, Lee S, Lee H, Cho M, Schaffer DV, Jang JH. AAVR-Displaying Interfaces: Serotype-Independent Adeno-Associated Virus Capture and Local Delivery Systems. Molecular Therapy. Nucleic Acids. 18: 432-443. PMID 31670142 DOI: 10.1016/J.Omtn.2019.09.015  1
2019 Bao X, Adil MM, Muckom R, Zimmermann JA, Tran A, Suhy N, Xu Y, Sampayo RG, Clark DS, Schaffer DV. Gene Editing to Generate Versatile Human Pluripotent Stem Cell Reporter Lines for Analysis of Differentiation and Lineage Tracing. Stem Cells (Dayton, Ohio). PMID 31634414 DOI: 10.1002/Stem.3096  1
2019 Ekman FK, Ojala DS, Adil MM, Lopez PA, Schaffer DV, Gaj T. CRISPR-Cas9-Mediated Genome Editing Increases Lifespan and Improves Motor Deficits in a Huntington's Disease Mouse Model. Molecular Therapy. Nucleic Acids. 17: 829-839. PMID 31465962 DOI: 10.1016/J.Omtn.2019.07.009  1
2019 Qiao EL, Kumar S, Schaffer DV. Mastering their own fates through the matrix. Nature Materials. 18: 779-780. PMID 31332317 DOI: 10.1038/S41563-019-0429-X  1
2019 Chen S, Sun S, Moonen D, Lee C, Lee AY, Schaffer DV, He L. CRISPR-READI: Efficient Generation of Knockin Mice by CRISPR RNP Electroporation and AAV Donor Infection. Cell Reports. 27: 3780-3789.e4. PMID 31242412 DOI: 10.1016/J.Celrep.2019.05.103  1
2019 Zimmermann JA, Schaffer DV. Engineering biomaterials to control the neural differentiation of stem cells. Brain Research Bulletin. 150: 50-60. PMID 31103526 DOI: 10.1016/J.Brainresbull.2019.05.007  1
2019 Barnes C, Scheideler O, Schaffer D. Engineering the AAV capsid to evade immune responses. Current Opinion in Biotechnology. 60: 99-103. PMID 30807882 DOI: 10.1016/J.Copbio.2019.01.002  0.16
2018 Fuentes CM, Schaffer DV. Adeno-associated virus-mediated delivery of CRISPR-Cas9 for genome editing in the central nervous system. Current Opinion in Biomedical Engineering. 7: 33-41. PMID 34046535 DOI: 10.1016/j.cobme.2018.08.003  1
2018 Adil MM, Schaffer DV. Cheaper and less variable expansion. Nature Biomedical Engineering. 2: 144-145. PMID 31015716 DOI: 10.1038/S41551-018-0209-Y  1
2018 Mukherjee A, Dhar N, Stathos M, Schaffer DV, Kane RS. Understanding How Wnt Influences Destruction Complex Activity and β-Catenin Dynamics. Iscience. 6: 13-21. PMID 30240607 DOI: 10.1016/J.Isci.2018.07.007  1
2018 Nierode GJ, Gopal S, Kwon P, Clark DS, Schaffer DV, Dordick JS. High-throughput identification of factors promoting neuronal differentiation of human neural progenitor cells in microscale 3D cell culture. Biotechnology and Bioengineering. PMID 30229860 DOI: 10.1002/Bit.26839  1
2018 Sun S, Schaffer DV. Corrigendum to "Engineered viral vectors for functional interrogation, deconvolution, and manipulation of neural circuits" [Curr. Opin. Neurobiol. 50 (2018) 163-170]. Current Opinion in Neurobiology. PMID 30196036 DOI: 10.1016/J.Conb.2018.08.005  1
2018 Muckom R, McFarland S, Yang C, Perea B, Gentes M, Murugappan A, Tran E, Dordick JS, Clark DS, Schaffer DV. High-Throughput Combinatorial Screening Reveals Interactions Between Signaling Molecules that Regulate Adult Neural Stem Cell Fate. Biotechnology and Bioengineering. PMID 30102775 DOI: 10.1002/Bit.26815  1
2018 Hauser M, Yan R, Li W, Repina NA, Schaffer DV, Xu K. The Spectrin-Actin-Based Periodic Cytoskeleton as a Conserved Nanoscale Scaffold and Ruler of the Neural Stem Cell Lineage. Cell Reports. 24: 1512-1522. PMID 30089262 DOI: 10.1016/J.Celrep.2018.07.005  1
2018 Dong M, Spelke DP, Lee YK, Chung JK, Yu CH, Schaffer DV, Groves JT. Spatiomechanical Modulation of EphB4-ephrin-B2 Signaling in Neural Stem Cell Differentiation. Biophysical Journal. PMID 30075851 DOI: 10.1016/J.Bpj.2018.06.031  1
2018 Mosher KI, Schaffer DV. Proliferation versus Differentiation: Redefining Retinoic Acid's Role. Stem Cell Reports. 10: 1673-1675. PMID 29874625 DOI: 10.1016/J.Stemcr.2018.05.011  1
2018 Ekerdt BL, Fuentes CM, Lei Y, Adil MM, Ramasubramanian A, Segalman RA, Schaffer DV. Thermoreversible Hyaluronic Acid-PNIPAAm Hydrogel Systems for 3D Stem Cell Culture. Advanced Healthcare Materials. e1800225. PMID 29717823 DOI: 10.1002/Adhm.201800225  1
2018 Adil MM, Gaj T, Rao AT, Kulkarni RU, Fuentes CM, Ramadoss GN, Ekman FK, Miller EW, Schaffer DV. hPSC-Derived Striatal Cells Generated Using a Scalable 3D Hydrogel Promote Recovery in a Huntington Disease Mouse Model. Stem Cell Reports. PMID 29628395 DOI: 10.1016/J.Stemcr.2018.03.007  1
2018 Sun S, Schaffer DV. Engineered viral vectors for functional interrogation, deconvolution, and manipulation of neural circuits. Current Opinion in Neurobiology. 50: 163-170. PMID 29614429 DOI: 10.1016/J.Conb.2017.12.011  1
2018 Adil MM, Schaffer DV. hPSC-derived Midbrain Dopaminergic Neurons Generated in a Scalable 3-D Biomaterial. Current Protocols in Stem Cell Biology. 44: 2D.21.1-2D.21.17. PMID 29512105 DOI: 10.1002/Cpsc.47  1
2018 Chen KS, Xu M, Zhang Z, Chang WC, Gaj T, Schaffer DV, Dan Y. A Hypothalamic Switch for REM and Non-REM Sleep. Neuron. PMID 29478915 DOI: 10.1016/J.Neuron.2018.02.005  1
2018 Day TP, Byrne LC, Flannery JG, Schaffer DV. Screening for Neutralizing Antibodies Against Natural and Engineered AAV Capsids in Nonhuman Primate Retinas. Methods in Molecular Biology (Clifton, N.J.). 1715: 239-249. PMID 29188518 DOI: 10.1007/978-1-4939-7522-8_17  1
2017 Kang P, Kumar S, Schaffer D. Novel biomaterials to study neural stem cell mechanobiology and improve cell-replacement therapies. Current Opinion in Biomedical Engineering. 4: 13-20. PMID 29399646 DOI: 10.1016/J.Cobme.2017.09.005  1
2017 Mukherjee A, Repina NA, Schaffer DV, Kane RS. Optogenetic tools for cell biological applications. Journal of Thoracic Disease. 9: 4867-4870. PMID 29312679 DOI: 10.21037/Jtd.2017.11.73  1
2017 Gaj T, Ojala DS, Ekman FK, Byrne LC, Limsirichai P, Schaffer DV. In vivo genome editing improves motor function and extends survival in a mouse model of ALS. Science Advances. 3: eaar3952. PMID 29279867 DOI: 10.1126/Sciadv.Aar3952  1
2017 Kang PH, Kumar S, Schaffer DV. Matrix degradation: Making way for neural stemness. Nature Materials. 16: 1174-1176. PMID 29170553 DOI: 10.1038/Nmat5043  1
2017 Epstein BE, Schaffer DV. Combining Engineered Nucleases with Adeno-associated Viral Vectors for Therapeutic Gene Editing. Advances in Experimental Medicine and Biology. 1016: 29-42. PMID 29130152 DOI: 10.1007/978-3-319-63904-8_2  1
2017 Mosher KI, Schaffer DV. Influence of hippocampal niche signals on neural stem cell functions during aging. Cell and Tissue Research. PMID 29124394 DOI: 10.1007/S00441-017-2709-6  1
2017 Ojala DS, Sun S, Santiago-Ortiz JL, Shapiro MG, Romero PA, Schaffer DV. In Vivo Selection of a Computationally Designed SCHEMA AAV Library Yields a Novel Variant for Infection of Adult Neural Stem Cells in the SVZ. Molecular Therapy : the Journal of the American Society of Gene Therapy. PMID 28988711 DOI: 10.1016/J.Ymthe.2017.09.006  1
2017 Wooley DP, Sharma P, Weinstein JR, Narayan PKL, Schaffer DV, Excoffon KJDA. A directed evolution approach to select for novel Adeno-associated virus capsids on an HIV-1 producer T cell line. Journal of Virological Methods. PMID 28918073 DOI: 10.1016/J.Jviromet.2017.09.008  1
2017 Sinn PL, Hwang BY, Li N, Ortiz JLS, Shirazi E, Parekh KR, Cooney AL, Schaffer DV, McCray PB. Novel GP64 envelope variants for improved delivery to human airway epithelial cells. Gene Therapy. PMID 28880020 DOI: 10.1038/Gt.2017.78  1
2017 Repina NA, Rosenbloom A, Mukherjee A, Schaffer DV, Kane RS. At Light Speed: Advances in Optogenetic Systems for Regulating Cell Signaling and Behavior. Annual Review of Chemical and Biomolecular Engineering. 8: 13-39. PMID 28592174 DOI: 10.1146/Annurev-Chembioeng-060816-101254  1
2017 Rodrigues GMC, Gaj T, Adil MM, Wahba J, Rao AT, Lorbeer FK, Kulkarni RU, Diogo MM, Cabral JMS, Miller EW, Hockemeyer D, Schaffer DV. Defined and Scalable Differentiation of Human Oligodendrocyte Precursors from Pluripotent Stem Cells in a 3D Culture System. Stem Cell Reports. PMID 28552605 DOI: 10.1016/J.Stemcr.2017.04.027  1
2017 Adil MM, Vazin T, Ananthanarayanan B, Rodrigues GMC, Rao AT, Kulkarni RU, Miller EW, Kumar S, Schaffer DV. Engineered hydrogels increase the post-transplantation survival of encapsulated hESC-derived midbrain dopaminergic neurons. Biomaterials. 136: 1-11. PMID 28505596 DOI: 10.1016/J.Biomaterials.2017.05.008  1
2017 Gaj T, Staahl BT, Rodrigues GM, Limsirichai P, Ekman FK, Doudna JA, Schaffer DV. Targeted gene knock-in by homology-directed genome editing using Cas9 ribonucleoprotein and AAV donor delivery. Nucleic Acids Research. PMID 28334779 DOI: 10.1093/Nar/Gkx154  1
2017 Adil MM, Rodrigues GM, Kulkarni RU, Rao AT, Chernavsky NE, Miller EW, Schaffer DV. Efficient generation of hPSC-derived midbrain dopaminergic neurons in a fully defined, scalable, 3D biomaterial platform. Scientific Reports. 7: 40573. PMID 28091566 DOI: 10.1038/Srep40573  1
2016 Nierode GJ, Perea BC, McFarland SK, Pascoal JF, Clark DS, Schaffer DV, Dordick JS. High-Throughput Toxicity and Phenotypic Screening of 3D Human Neural Progenitor Cell Cultures on a Microarray Chip Platform. Stem Cell Reports. 7: 970-982. PMID 28157485 DOI: 10.1016/J.Stemcr.2016.10.001  1
2016 Kulkarni RU, Yin H, Pourmandi N, James F, Adil MM, Schaffer DV, Wang Y, Miller EW. A Rationally Designed, General Strategy for Membrane Orientation of Photoinduced Electron Transfer-Based Voltage-Sensitive Dyes. Acs Chemical Biology. PMID 28004909 DOI: 10.1021/Acschembio.6B00981  1
2016 Gaj T, Schaffer DV. Adeno-Associated Virus-Mediated Delivery of CRISPR-Cas Systems for Genome Engineering in Mammalian Cells. Cold Spring Harbor Protocols. 2016: pdb.prot086868. PMID 27803249 DOI: 10.1101/Pdb.Prot086868  1
2016 Tervo DG, Hwang BY, Viswanathan S, Gaj T, Lavzin M, Ritola KD, Lindo S, Michael S, Kuleshova E, Ojala D, Huang CC, Gerfen CR, Schiller J, Dudman JT, Hantman AW, ... ... Schaffer DV, et al. A Designer AAV Variant Permits Efficient Retrograde Access to Projection Neurons. Neuron. PMID 27720486 DOI: 10.1016/J.Neuron.2016.09.021  1
2016 Steines B, Dickey DD, Bergen J, Excoffon KJ, Weinstein JR, Li X, Yan Z, Alaiwa MH, Shah VS, Bouzek DC, Powers LS, Gansemer ND, Ostedgaard LS, Engelhardt JF, Stoltz DA, ... ... Schaffer DV, et al. CFTR gene transfer with AAV improves early cystic fibrosis pig phenotypes. Jci Insight. 1: e88728. PMID 27699238 DOI: 10.1172/Jci.Insight.88728  1
2016 Yao K, Qiu S, Tian L, Snider WD, Flannery JG, Schaffer DV, Chen B. Wnt Regulates Proliferation and Neurogenic Potential of Müller Glial Cells via a Lin28/let-7 miRNA-Dependent Pathway in Adult Mammalian Retinas. Cell Reports. 17: 165-78. PMID 27681429 DOI: 10.1016/J.Celrep.2016.08.078  1
2016 Rammensee S, Kang MS, Georgiou K, Kumar S, Schaffer DV. Dynamics of Mechanosensitive Neural Stem Cell Differentiation. Stem Cells (Dayton, Ohio). PMID 27573749 DOI: 10.1002/Stem.2489  1
2016 Sun S, Schaffer DV. Viral infection: A key host receptor for AAV. Nature Microbiology. 1: 15027. PMID 27572162 DOI: 10.1038/Nmicrobiol.2015.27  1
2016 Luque T, Kang MS, Schaffer DV, Kumar S. Microelastic mapping of the rat dentate gyrus. Royal Society Open Science. 3: 150702. PMID 27152213 DOI: 10.1098/Rsos.150702  1
2016 Altiok EI, Santiago-Ortiz JL, Svedlund FL, Zbinden A, Jha AK, Bhatnagar D, Loskill P, Jackson WM, Schaffer DV, Healy KE. Multivalent hyaluronic acid bioconjugates improve sFlt-1 activity in vitro. Biomaterials. 93: 95-105. PMID 27086270 DOI: 10.1016/J.Biomaterials.2016.03.017  1
2016 Zheng B, von See MP, Yu E, Gunel B, Lu K, Vazin T, Schaffer DV, Goodwill PW, Conolly SM. Quantitative Magnetic Particle Imaging Monitors the Transplantation, Biodistribution, and Clearance of Stem Cells In Vivo. Theranostics. 6: 291-301. PMID 26909106 DOI: 10.7150/Thno.13728  1
2016 Santiago-Ortiz JL, Schaffer DV. Adeno-associated virus (AAV) vectors in cancer gene therapy. Journal of Controlled Release : Official Journal of the Controlled Release Society. PMID 26796040 DOI: 10.1016/J.Jconrel.2016.01.001  1
2016 Chen S, Bremer AW, Scheideler OJ, Na YS, Todhunter ME, Hsiao S, Bomdica PR, Maharbiz MM, Gartner ZJ, Schaffer DV. Interrogating cellular fate decisions with high-throughput arrays of multiplexed cellular communities. Nature Communications. 7: 10309. PMID 26754526 DOI: 10.1038/Ncomms10309  1
2016 Luque T, Kang MS, Schaffer DV, Kumar S. Microelastic mapping of the rat dentate gyrus Royal Society Open Science. 3. DOI: 10.1098/rsos.150702  1
2016 Byrne LC, Visel M, Dufour V, Marinho FP, Aguirre GD, Beltran WA, Flannery JG, Schaffer DV. 617. Identification of Novel AAV Capsid Variants with Enhanced Tropism for the Canine Outer Retina Following Intravitreal Delivery Molecular Therapy. 24: S244-S245. DOI: 10.1016/S1525-0016(16)33425-6  1
2015 A Kotterman M, Schaffer DV. Engineered AAV vectors for improved central nervous system gene delivery. Neurogenesis (Austin, Tex.). 2: e1122700. PMID 27606332 DOI: 10.1080/23262133.2015.1122700  0.01
2015 Kotterman MA, Chalberg TW, Schaffer DV. Viral Vectors for Gene Therapy: Translational and Clinical Outlook. Annual Review of Biomedical Engineering. 17: 63-89. PMID 26643018 DOI: 10.1146/Annurev-Bioeng-071813-104938  1
2015 Limsirichai P, Gaj T, Schaffer DV. CRISPR-mediated activation of latent HIV-1 expression. Molecular Therapy : the Journal of the American Society of Gene Therapy. PMID 26607397 DOI: 10.1038/Mt.2015.213  1
2015 Tsukamoto A, Abbot SE, Kadyk LC, DeWitt ND, Schaffer DV, Wertheim JA, Whittlesey KJ, Werner MJ. Challenging Regeneration to Transform Medicine. Stem Cells Translational Medicine. PMID 26607174 DOI: 10.5966/Sctm.2015-0180  1
2015 Burroughs AM, Zhang D, Schäffer DE, Iyer LM, Aravind L. Comparative genomic analyses reveal a vast, novel network of nucleotide-centric systems in biological conflicts, immunity and signaling. Nucleic Acids Research. PMID 26590262 DOI: 10.1093/nar/gkv1267  0.04
2015 Raposo AC, Ofri R, Schaffer DP, Gomes Júnior DC, Libório FA, Martins Filho EF, Oriá AP. Evaluation of ophthalmic and hemodynamic parameters in capuchin monkeys (Sapajus sp.) submitted to dissociative anesthetic protocols. Journal of Medical Primatology. PMID 26457384 DOI: 10.1111/Jmp.12200  0.01
2015 Ringwalt C, Shanahan M, Wodarski S, Jones J, Schaffer D, Fusaro A, Paulozzi L, Garrettson M, Ford M. A Randomized Controlled Trial of an Emergency Department Intervention for Patients with Chronic Noncancer Pain. The Journal of Emergency Medicine. PMID 26423915 DOI: 10.1016/J.Jemermed.2015.03.004  1
2015 Gaj T, Epstein BE, Schaffer DV. Genome Engineering Using Adeno-associated Virus: Basic and Clinical Research Applications. Molecular Therapy : the Journal of the American Society of Gene Therapy. PMID 26373345 DOI: 10.1038/Mt.2015.151  1
2015 Zheng B, Vazin T, Goodwill PW, Conway A, Verma A, Ulku Saritas E, Schaffer D, Conolly SM. Magnetic Particle Imaging tracks the long-term fate of in vivo neural cell implants with high image contrast. Scientific Reports. 5: 14055. PMID 26358296 DOI: 10.1038/Srep14055  1
2015 Santiago-Ortiz J, Ojala DS, Westesson O, Weinstein JR, Wong SY, Steinsapir A, Kumar S, Holmes I, Schaffer DV. AAV ancestral reconstruction library enables selection of broadly infectious viral variants. Gene Therapy. PMID 26186661 DOI: 10.1038/Gt.2015.74  1
2015 Han BW, Layman H, Rode NA, Conway A, Schaffer DV, Boudreau NJ, Jackson WM, Healy KE. Multivalent Conjugates of Sonic Hedgehog Accelerate Diabetic Wound Healing. Tissue Engineering. Part A. 21: 2366-78. PMID 26154888 DOI: 10.1089/Ten.Tea.2014.0281  1
2015 Yousef H, Conboy MJ, Morgenthaler A, Schlesinger C, Bugaj L, Paliwal P, Greer C, Conboy IM, Schaffer D. Systemic attenuation of the TGF-β pathway by a single drug simultaneously rejuvenates hippocampal neurogenesis and myogenesis in the same old mammal. Oncotarget. 6: 11959-78. PMID 26003168 DOI: 10.18632/Oncotarget.3851  1
2015 Deng Y, Wang H, Hamamoto R, Schaffer D, Duan S. Functional genomics, genetics, and bioinformatics. Biomed Research International. 2015: 184824. PMID 25977917 DOI: 10.1155/2015/184824  0.04
2015 Kotterman MA, Vazin T, Schaffer DV. Enhanced selective gene delivery to neural stem cells in vivo by an adeno-associated viral variant. Development (Cambridge, England). 142: 1885-92. PMID 25968319 DOI: 10.1242/Dev.115253  1
2015 Dey SS, Foley JE, Limsirichai P, Schaffer DV, Arkin AP. Orthogonal control of expression mean and variance by epigenetic features at different genomic loci. Molecular Systems Biology. 11: 806. PMID 25943345 DOI: 10.15252/Msb.20145704  1
2015 Bugaj LJ, Spelke DP, Mesuda CK, Varedi M, Kane RS, Schaffer DV. Regulation of endogenous transmembrane receptors through optogenetic Cry2 clustering. Nature Communications. 6: 6898. PMID 25902152 DOI: 10.1038/Ncomms7898  1
2015 Jha AK, Tharp KM, Ye J, Santiago-Ortiz JL, Jackson WM, Stahl A, Schaffer DV, Yeghiazarians Y, Healy KE. Enhanced survival and engraftment of transplanted stem cells using growth factor sequestering hydrogels. Biomaterials. 47: 1-12. PMID 25682155 DOI: 10.1016/J.Biomaterials.2014.12.043  1
2015 Fritz AL, Adil MM, Mao SR, Schaffer DV. cAMP and EPAC Signaling Functionally Replace OCT4 During Induced Pluripotent Stem Cell Reprogramming. Molecular Therapy : the Journal of the American Society of Gene Therapy. 23: 952-63. PMID 25666918 DOI: 10.1038/Mt.2015.28  1
2015 Yousef H, Morgenthaler A, Schlesinger C, Bugaj L, Conboy IM, Schaffer DV. Age-Associated Increase in BMP Signaling Inhibits Hippocampal Neurogenesis. Stem Cells (Dayton, Ohio). 33: 1577-88. PMID 25538007 DOI: 10.1002/Stem.1943  1
2015 Kotterman MA, Yin L, Strazzeri JM, Flannery JG, Merigan WH, Schaffer DV. Antibody neutralization poses a barrier to intravitreal adeno-associated viral vector gene delivery to non-human primates. Gene Therapy. 22: 116-26. PMID 25503696 DOI: 10.1038/Gt.2014.115  1
2015 Byrne LC, Lin YJ, Lee T, Schaffer DV, Flannery JG. The expression pattern of systemically injected AAV9 in the developing mouse retina is determined by age. Molecular Therapy : the Journal of the American Society of Gene Therapy. 23: 290-6. PMID 25224467 DOI: 10.1038/Mt.2014.181  1
2015 Fritz AL, Mao SR, West MG, Schaffer DV. A medium-throughput analysis of signaling pathways involved in early stages of stem cell reprogramming. Biotechnology and Bioengineering. 112: 209-19. PMID 25065366 DOI: 10.1002/Bit.25336  1
2015 Ojala DS, Amara DP, Schaffer DV. Adeno-associated virus vectors and neurological gene therapy. The Neuroscientist : a Review Journal Bringing Neurobiology, Neurology and Psychiatry. 21: 84-98. PMID 24557878 DOI: 10.1177/1073858414521870  1
2015 Ojala DS, Santiago-Ortiz J, Westesson O, Weinstein JR, Wong SY, Steinsapir A, Kumar S, Holmes I, Schaffer D. 260. AAV Ancestral Reconstruction Library Enables Selection of Broadly Infectious Viral Variants Molecular Therapy. 23. DOI: 10.1016/S1525-0016(16)33869-2  1
2014 Schaffer DV. AAV shuffles to the liver: commentary on Lisowski et al. Molecular Therapy. Methods & Clinical Development. 1: 14006. PMID 26015952 DOI: 10.1038/Mtm.2014.6  0.01
2014 Lei Y, Jeong D, Xiao J, Schaffer DV. Developing Defined and Scalable 3D Culture Systems for Culturing Human Pluripotent Stem Cells at High Densities. Cellular and Molecular Bioengineering. 7: 172-183. PMID 25419247 DOI: 10.1007/S12195-014-0333-Z  1
2014 Reinhart-King CA, Mooney DJ, Schaffer DV. The Young Innovators of Cellular and Molecular Bioengineering. Cellular and Molecular Bioengineering. 7: 291-292. PMID 25309632 DOI: 10.1007/s12195-014-0352-9  1
2014 Zimmermann R, Marcus U, Schäffer D, Leicht A, Wenz B, Nielsen S, Santos-Hövener C, Ross RS, Stambouli O, Ratsch BA, Bannert N, Bock CT, Kücherer C, Hamouda O. A multicentre sero-behavioural survey for hepatitis B and C, HIV and HTLV among people who inject drugs in Germany using respondent driven sampling. Bmc Public Health. 14: 845. PMID 25124485 DOI: 10.1186/1471-2458-14-845  1
2014 Yousef H, Conboy MJ, Mamiya H, Zeiderman M, Schlesinger C, Schaffer DV, Conboy IM. Mechanisms of action of hESC-secreted proteins that enhance human and mouse myogenesis. Aging. 6: 602-20. PMID 25109702  1
2014 Stöver HJ, Schäffer D. SMOKE IT! Promoting a change of opiate consumption pattern - from injecting to inhaling. Harm Reduction Journal. 11: 18. PMID 24973031 DOI: 10.1186/1477-7517-11-18  0.04
2014 Shapiro MG, Ramirez RM, Sperling LJ, Sun G, Sun J, Pines A, Schaffer DV, Bajaj VS. Genetically encoded reporters for hyperpolarized xenon magnetic resonance imaging. Nature Chemistry. 6: 629-34. PMID 24950334 DOI: 10.1038/Nchem.1934  1
2014 Hughes AJ, Spelke DP, Xu Z, Kang CC, Schaffer DV, Herr AE. Single-cell western blotting. Nature Methods. 11: 749-55. PMID 24880876 DOI: 10.1038/Nmeth.2992  1
2014 Kotterman MA, Schaffer DV. Engineering adeno-associated viruses for clinical gene therapy. Nature Reviews. Genetics. 15: 445-51. PMID 24840552 DOI: 10.1038/Nrg3742  1
2014 Yin L, Masella B, Dalkara D, Zhang J, Flannery JG, Schaffer DV, Williams DR, Merigan WH. Imaging light responses of foveal ganglion cells in the living macaque eye. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 34: 6596-605. PMID 24806684 DOI: 10.1523/Jneurosci.4438-13.2014  1
2014 Byrne LC, Oztürk BE, Lee T, Fortuny C, Visel M, Dalkara D, Schaffer DV, Flannery JG. Retinoschisin gene therapy in photoreceptors, Müller glia or all retinal cells in the Rs1h-/- mouse. Gene Therapy. 21: 585-92. PMID 24694538 DOI: 10.1038/Gt.2014.31  1
2014 Cao J, Arha M, Sudrik C, Schaffer DV, Kane RS. Bidirectional regulation of mRNA translation in mammalian cells by using PUF domains. Angewandte Chemie (International Ed. in English). 53: 4900-4. PMID 24677733 DOI: 10.1002/Anie.201402095  1
2014 Day TP, Byrne LC, Schaffer DV, Flannery JG. Advances in AAV vector development for gene therapy in the retina. Advances in Experimental Medicine and Biology. 801: 687-93. PMID 24664759 DOI: 10.1007/978-1-4614-3209-8_86  1
2014 Shapiro MG, Goodwill PW, Neogy A, Yin M, Foster FS, Schaffer DV, Conolly SM. Biogenic gas nanostructures as ultrasonic molecular reporters. Nature Nanotechnology. 9: 311-6. PMID 24633522 DOI: 10.1038/Nnano.2014.32  1
2014 Bartel MA, Schaffer DV. Enhanced gene targeting of adult and pluripotent stem cells using evolved adeno-associated virus. Methods in Molecular Biology (Clifton, N.J.). 1114: 169-79. PMID 24557903 DOI: 10.1007/978-1-62703-761-7_11  1
2014 Conway A, Schaffer DV. Biomaterial microenvironments to support the generation of new neurons in the adult brain. Stem Cells (Dayton, Ohio). 32: 1220-9. PMID 24449485 DOI: 10.1002/Stem.1650  1
2014 Loring JF, McDevitt TC, Palecek SP, Schaffer DV, Zandstra PW, Nerem RM. A global assessment of stem cell engineering. Tissue Engineering. Part A. 20: 2575-89. PMID 24428577 DOI: 10.1089/Ten.Tea.2013.0468  1
2014 Vacca O, Darche M, Schaffer DV, Flannery JG, Sahel JA, Rendon A, Dalkara D. AAV-mediated gene delivery in Dp71-null mouse model with compromised barriers. Glia. 62: 468-76. PMID 24382652 DOI: 10.1002/Glia.22617  1
2014 Vazin T, Ashton RS, Conway A, Rode NA, Lee SM, Bravo V, Healy KE, Kane RS, Schaffer DV. The effect of multivalent Sonic hedgehog on differentiation of human embryonic stem cells into dopaminergic and GABAergic neurons. Biomaterials. 35: 941-8. PMID 24172856 DOI: 10.1016/J.Biomaterials.2013.10.025  1
2014 Vazin T, Ball KA, Lu H, Park H, Ataeijannati Y, Head-Gordon T, Poo MM, Schaffer DV. Efficient derivation of cortical glutamatergic neurons from human pluripotent stem cells: a model system to study neurotoxicity in Alzheimer's disease. Neurobiology of Disease. 62: 62-72. PMID 24055772 DOI: 10.1016/J.Nbd.2013.09.005  1
2014 Conway A, Spelke DP, Schaffer DV. Conjugation of proteins to polymer chains to create multivalent molecules. Methods in Molecular Biology (Clifton, N.J.). 1202: 95-102. PMID 24014311 DOI: 10.1007/7651_2013_32  1
2014 Sudrik C, Arha M, Cao J, Kane RS, Schaffer DV. Design of a translational repression based RNA switch in mammalian cells Proceedings of the Ieee Annual Northeast Bioengineering Conference, Nebec. 2014. DOI: 10.1109/NEBEC.2014.6972948  1
2014 Cao J, Arha M, Sudrik C, Kane RS, Bugaj LJ, Schaffer DV. Characterization of an optogenetic translation activation system Proceedings of the Ieee Annual Northeast Bioengineering Conference, Nebec. 2014. DOI: 10.1109/NEBEC.2014.6972749  1
2014 Vazin T, Ball KA, Lu H, Park H, Ataeijannati Y, Head-Gordon T, Poo Mm, Schaffer DV. Corrigendum to "Efficient derivation of cortical glutamatergic neurons from human pluripotent stem cells: A model system to study neurotoxicity in Alzheimer's disease" [Neurobiol. Dis. 62 (2014) 62-72] Neurobiology of Disease. 65: 1. DOI: 10.1016/J.Nbd.2013.12.012  1
2013 Ekerdt BL, Segalman RA, Schaffer DV. Spatial organization of cell-adhesive ligands for advanced cell culture. Biotechnology Journal. 8: 1411-23. PMID 24318636 DOI: 10.1002/Biot.201300302  1
2013 Lei Y, Schaffer DV. A fully defined and scalable 3D culture system for human pluripotent stem cell expansion and differentiation. Proceedings of the National Academy of Sciences of the United States of America. 110: E5039-48. PMID 24248365 DOI: 10.1073/Pnas.1309408110  1
2013 Conway A, Vazin T, Spelke DP, Rode NA, Healy KE, Kane RS, Schaffer DV. Multivalent ligands control stem cell behaviour in vitro and in vivo. Nature Nanotechnology. 8: 831-8. PMID 24141540 DOI: 10.1038/Nnano.2013.205  1
2013 Downing TL, Soto J, Morez C, Houssin T, Fritz A, Yuan F, Chu J, Patel S, Schaffer DV, Li S. Biophysical regulation of epigenetic state and cell reprogramming. Nature Materials. 12: 1154-62. PMID 24141451 DOI: 10.1038/Nmat3777  1
2013 Byrne LC, Khalid F, Lee T, Zin EA, Greenberg KP, Visel M, Schaffer DV, Flannery JG. AAV-mediated, optogenetic ablation of Müller Glia leads to structural and functional changes in the mouse retina. Plos One. 8: e76075. PMID 24086689 DOI: 10.1371/Journal.Pone.0076075  1
2013 Cao J, Arha M, Sudrik C, Bugaj LJ, Schaffer DV, Kane RS. Light-inducible activation of target mRNA translation in mammalian cells. Chemical Communications (Cambridge, England). 49: 8338-40. PMID 23925486 DOI: 10.1039/C3Cc44866E  1
2013 Miller-Jensen K, Skupsky R, Shah PS, Arkin AP, Schaffer DV. Genetic selection for context-dependent stochastic phenotypes: Sp1 and TATA mutations increase phenotypic noise in HIV-1 gene expression. Plos Computational Biology. 9: e1003135. PMID 23874178 DOI: 10.1371/Journal.Pcbi.1003135  1
2013 Sudrik C, Arha M, Cao J, Schaffer DV, Kane RS. Translational repression using BIV Tat peptide-TAR RNA interaction in mammalian cells. Chemical Communications (Cambridge, England). 49: 7457-9. PMID 23852014 DOI: 10.1039/C3Cc43086C  1
2013 Yousef H, Conboy MJ, Li J, Zeiderman M, Vazin T, Schlesinger C, Schaffer DV, Conboy IM. hESC-secreted proteins can be enriched for multiple regenerative therapies by heparin-binding. Aging. 5: 357-72. PMID 23793469  1
2013 Dalkara D, Byrne LC, Klimczak RR, Visel M, Yin L, Merigan WH, Flannery JG, Schaffer DV. In vivo-directed evolution of a new adeno-associated virus for therapeutic outer retinal gene delivery from the vitreous. Science Translational Medicine. 5: 189ra76. PMID 23761039 DOI: 10.1126/Scitranslmed.3005708  1
2013 Keung AJ, Dong M, Schaffer DV, Kumar S. Pan-neuronal maturation but not neuronal subtype differentiation of adult neural stem cells is mechanosensitive. Scientific Reports. 3: 1817. PMID 23660869 DOI: 10.1038/Srep01817  1
2013 Wikswo JP, Block FE, Cliffel DE, Goodwin CR, Marasco CC, Markov DA, McLean DL, McLean JA, McKenzie JR, Reiserer RS, Samson PC, Schaffer DK, Seale KT, Sherrod SD. Engineering challenges for instrumenting and controlling integrated organ-on-chip systems. Ieee Transactions On Bio-Medical Engineering. 60: 682-90. PMID 23380852 DOI: 10.1109/Tbme.2013.2244891  1
2013 Bugaj LJ, Choksi AT, Mesuda CK, Kane RS, Schaffer DV. Optogenetic protein clustering and signaling activation in mammalian cells. Nature Methods. 10: 249-52. PMID 23377377 DOI: 10.1038/Nmeth.2360  1
2013 Hwang BY, Schaffer DV. Engineering a serum-resistant and thermostable vesicular stomatitis virus G glycoprotein for pseudotyping retroviral and lentiviral vectors. Gene Therapy. 20: 807-15. PMID 23364315 DOI: 10.1038/Gt.2013.1  1
2013 Chen S, Schaffer DV. Newborn neuroblasts feel the field in the adult brain. Embo Reports. 14: 105-6. PMID 23328741 DOI: 10.1038/Embor.2012.223  1
2013 Pernet V, Joly S, Dalkara D, Jordi N, Schwarz O, Christ F, Schaffer DV, Flannery JG, Schwab ME. Long-distance axonal regeneration induced by CNTF gene transfer is impaired by axonal misguidance in the injured adult optic nerve. Neurobiology of Disease. 51: 202-13. PMID 23194670 DOI: 10.1016/J.Nbd.2012.11.011  1
2013 Yin L, Masella BD, Geng Y, Dalkara D, Osakada F, Sharma R, Zhang J, Cetin AH, Callaway EM, Flannery JG, Schaffer DV, Williams DR, Merigan WH. Optical recording of the light response of ganglion cells in the living eye Optics Infobase Conference Papers. DOI: 10.1364/Fio.2013.Ftu4I.3  1
2013 Yang W, Zheng B, Vazin T, Goodwill PW, Saritas EU, Schaffer DV, Conolly SM. In vivo magnetic nanoparticle cytometer for stem cells in small animals 2013 International Workshop On Magnetic Particle Imaging, Iwmpi 2013. DOI: 10.1109/IWMPI.2013.6528383  1
2013 Zheng B, Vazin T, Yang W, Goodwill PW, Saritas EU, Croft LR, Schaffer DV, Conolly SM. Quantitative stem cell imaging with magnetic particle imaging 2013 International Workshop On Magnetic Particle Imaging, Iwmpi 2013. DOI: 10.1109/IWMPI.2013.6528323  1
2013 Campbell AS, Land WH, Margolis D, Mathur R, Schaffer D. Investigating the GRNN oracle as a method for combining multiple predictive models of colon cancer recurrence from gene microarrays Procedia Computer Science. 20: 374-378. DOI: 10.1016/j.procs.2013.09.289  1
2013 Irwin EF, Pollock JF, Schaffer DV, Healy KE. Designing Tunable Artificial Matrices for Stem Cell Culture Handbook of Stem Cells. 2: 927-935. DOI: 10.1016/B978-0-12-385942-6.00076-7  1
2013 Hogle LF, Palecek SP, Schaffer D, Zandstra PW. Characterizing international stem cell research niches Regenerative Medicine Ethics: Governing Research and Knowledge Practices. 29-65. DOI: 10.1007/978-1-4614-9062-3_2  1
2013 Perry SL, Neumann SG, Neumann T, Cheng K, Ni J, Weinstein JR, Schaffer DV, Tirrell M. Challenges in nucleic acid-lipid films for transfection Aiche Journal. 59: 3203-3213. DOI: 10.1002/Aic.14198  1
2013 Sutton WM, Bowlin D, Schaffer D. Securing critical control systems in the power industry 56th Isa Powid Symposium 2013. 496: 275-289.  0.01
2013 Hughes AJ, Spelke DP, Xu Z, Schaffer DV, Herr AE. Single cell western blotting 17th International Conference On Miniaturized Systems For Chemistry and Life Sciences, Microtas 2013. 2: 1338-1340.  1
2013 Kotterman MA, Asuri P, Jang JH, Vazin T, Schaffer DV. Directed evolution of adeno-associated virus for enhanced gene delivery to pluripotent and adult neural stem cells Food, Pharmaceutical and Bioengineering Division 2013 - Core Programming Area At the 2013 Aiche Annual Meeting: Global Challenges For Engineering a Sustainable Future. 324.  1
2013 Lei Y, Schaffer D. Scalable production of dopaminergic neuron progenitors for treating parkinson's disease Food, Pharmaceutical and Bioengineering Division 2013 - Core Programming Area At the 2013 Aiche Annual Meeting: Global Challenges For Engineering a Sustainable Future. 316.  1
2013 Kotterman MA, Hwang BY, Stone D, Koerber JT, Couto L, Mingozzi F, High K, Schaffer DV. Directed evolution of adeno-associated virus for enhanced evasion of human neutralizing antibodies Food, Pharmaceutical and Bioengineering Division 2013 - Core Programming Area At the 2013 Aiche Annual Meeting: Global Challenges For Engineering a Sustainable Future. 413-414.  1
2012 Shah PS, Schaffer DV. Response to "HIV Escape From RNAi Antivirals: Yet Another Houdini Action?" Molecular Therapy. Nucleic Acids. 1: e28. PMID 28187853 DOI: 10.1038/mtna.2012.23  1
2012 Asokan A, Schaffer DV, Jude Samulski R. The AAV Vector Toolkit: Poised at the Clinical Crossroads. Molecular Therapy : the Journal of the American Society of Gene Therapy. 20: 699-708. PMID 28160612 DOI: 10.1038/mt.2011.287  1
2012 Shah PS, Schaffer DV. Response to "HIV Escape From RNAi Antivirals: Yet Another Houdini Action?". Molecular Therapy. Nucleic Acids. 1: e28. PMID 23344080 DOI: 10.1038/Mtna.2012.23  1
2012 Conway A, Schaffer DV. Biophysical regulation of stem cell behavior within the niche. Stem Cell Research & Therapy. 3: 50. PMID 23241436 DOI: 10.1186/Scrt141  1
2012 Goodwill PW, Saritas EU, Croft LR, Kim TN, Krishnan KM, Schaffer DV, Conolly SM. X-space MPI: magnetic nanoparticles for safe medical imaging. Advanced Materials (Deerfield Beach, Fla.). 24: 3870-7. PMID 22988557 DOI: 10.1002/Adma.201200221  1
2012 Ashton RS, Conway A, Pangarkar C, Bergen J, Lim KI, Shah P, Bissell M, Schaffer DV. Astrocytes regulate adult hippocampal neurogenesis through ephrin-B signaling. Nature Neuroscience. 15: 1399-406. PMID 22983209 DOI: 10.1038/Nn.3212  1
2012 Keung AJ, Asuri P, Kumar S, Schaffer DV. Soft microenvironments promote the early neurogenic differentiation but not self-renewal of human pluripotent stem cells. Integrative Biology : Quantitative Biosciences From Nano to Macro. 4: 1049-58. PMID 22854634 DOI: 10.1039/C2Ib20083J  1
2012 Pollock JF, Ashton RS, Rode NA, Schaffer DV, Healy KE. Molecular characterization of multivalent bioconjugates by size-exclusion chromatography with multiangle laser light scattering. Bioconjugate Chemistry. 23: 1794-801. PMID 22794081 DOI: 10.1021/Bc3000595  1
2012 Bugaj LJ, Schaffer DV. Bringing next-generation therapeutics to the clinic through synthetic biology. Current Opinion in Chemical Biology. 16: 355-61. PMID 22609142 DOI: 10.1016/J.Cbpa.2012.04.009  1
2012 Miller-Jensen K, Dey SS, Pham N, Foley JE, Arkin AP, Schaffer DV. Chromatin accessibility at the HIV LTR promoter sets a threshold for NF-κB mediated viral gene expression. Integrative Biology : Quantitative Biosciences From Nano to Macro. 4: 661-71. PMID 22555315 DOI: 10.1039/C2Ib20009K  1
2012 Bartel MA, Weinstein JR, Schaffer DV. Directed evolution of novel adeno-associated viruses for therapeutic gene delivery. Gene Therapy. 19: 694-700. PMID 22402323 DOI: 10.1038/Gt.2012.20  1
2012 Jgamadze D, Bergen J, Stone D, Jang JH, Schaffer DV, Isacoff EY, Pautot S. Colloids as mobile substrates for the implantation and integration of differentiated neurons into the mammalian brain. Plos One. 7: e30293. PMID 22295079 DOI: 10.1371/Journal.Pone.0030293  1
2012 Shah PS, Pham NP, Schaffer DV. HIV develops indirect cross-resistance to combinatorial RNAi targeting two distinct and spatially distant sites. Molecular Therapy : the Journal of the American Society of Gene Therapy. 20: 840-8. PMID 22294151 DOI: 10.1038/Mt.2012.3  1
2012 Asokan A, Schaffer DV, Samulski RJ. The AAV vector toolkit: poised at the clinical crossroads. Molecular Therapy : the Journal of the American Society of Gene Therapy. 20: 699-708. PMID 22273577 DOI: 10.1038/Mt.2011.287  1
2012 Dey SS, Xue Y, Joachimiak MP, Friedland GD, Burnett JC, Zhou Q, Arkin AP, Schaffer DV. Mutual information analysis reveals coevolving residues in Tat that compensate for two distinct functions in HIV-1 gene expression. The Journal of Biological Chemistry. 287: 7945-55. PMID 22253435 DOI: 10.1074/Jbc.M111.302653  1
2012 Pernet V, Joly S, Dalkara D, Schwarz O, Christ F, Schaffer D, Flannery JG, Schwab ME. Neuronal Nogo-A upregulation does not contribute to ER stress-associated apoptosis but participates in the regenerative response in the axotomized adult retina. Cell Death and Differentiation. 19: 1096-108. PMID 22193546 DOI: 10.1038/Cdd.2011.191  1
2012 An HJ, Gip P, Kim J, Wu S, Park KW, McVaugh CT, Schaffer DV, Bertozzi CR, Lebrilla CB. Extensive determination of glycan heterogeneity reveals an unusual abundance of high mannose glycans in enriched plasma membranes of human embryonic stem cells. Molecular & Cellular Proteomics : McP. 11: M111.010660. PMID 22147732 DOI: 10.1074/Mcp.M111.010660  1
2012 Asuri P, Bartel MA, Vazin T, Jang JH, Wong TB, Schaffer DV. Directed evolution of adeno-associated virus for enhanced gene delivery and gene targeting in human pluripotent stem cells. Molecular Therapy : the Journal of the American Society of Gene Therapy. 20: 329-38. PMID 22108859 DOI: 10.1038/Mt.2011.255  1
2012 Dalkara D, Byrne LC, Lee T, Hoffmann NV, Schaffer DV, Flannery JG. Enhanced gene delivery to the neonatal retina through systemic administration of tyrosine-mutated AAV9. Gene Therapy. 19: 176-81. PMID 22011645 DOI: 10.1038/Gt.2011.163  1
2012 Andrus BM, Blizinsky K, Vedell PT, Dennis K, Shukla PK, Schaffer DJ, Radulovic J, Churchill GA, Redei EE. Gene expression patterns in the hippocampus and amygdala of endogenous depression and chronic stress models. Molecular Psychiatry. 17: 49-61. PMID 21079605 DOI: 10.1038/Mp.2010.119  1
2012 Schaffer DL. It's time to stand up for earth science Journal of Geoscience Education. 60: 291-294. DOI: 10.5408/11-264.1  1
2011 Ashton RS, Keung AJ, Peltier J, Schaffer DV. Progress and prospects for stem cell engineering. Annual Review of Chemical and Biomolecular Engineering. 2: 479-502. PMID 22432628 DOI: 10.1146/Annurev-Chembioeng-061010-114105  1
2011 Bartel M, Schaffer D, Büning H. Enhancing the Clinical Potential of AAV Vectors by Capsid Engineering to Evade Pre-Existing Immunity. Frontiers in Microbiology. 2: 204. PMID 22065962 DOI: 10.3389/Fmicb.2011.00204  1
2011 Keung AJ, de Juan-Pardo EM, Schaffer DV, Kumar S. Rho GTPases mediate the mechanosensitive lineage commitment of neural stem cells. Stem Cells (Dayton, Ohio). 29: 1886-97. PMID 21956892 DOI: 10.1002/Stem.746  1
2011 Shah PS, Schaffer DV. Antiviral RNAi: translating science towards therapeutic success. Pharmaceutical Research. 28: 2966-82. PMID 21826573 DOI: 10.1007/S11095-011-0549-8  1
2011 Hester ME, Murtha MJ, Song S, Rao M, Miranda CJ, Meyer K, Tian J, Boulting G, Schaffer DV, Zhu MX, Pfaff SL, Gage FH, Kaspar BK. Rapid and efficient generation of functional motor neurons from human pluripotent stem cells using gene delivered transcription factor codes. Molecular Therapy : the Journal of the American Society of Gene Therapy. 19: 1905-12. PMID 21772256 DOI: 10.1038/Mt.2011.135  1
2011 Miller-Jensen K, Dey SS, Schaffer DV, Arkin AP. Varying virulence: epigenetic control of expression noise and disease processes. Trends in Biotechnology. 29: 517-25. PMID 21700350 DOI: 10.1016/J.Tibtech.2011.05.004  1
2011 Dickey DD, Excoffon KJ, Koerber JT, Bergen J, Steines B, Klesney-Tait J, Schaffer DV, Zabner J. Enhanced sialic acid-dependent endocytosis explains the increased efficiency of infection of airway epithelia by a novel adeno-associated virus. Journal of Virology. 85: 9023-30. PMID 21697483 DOI: 10.1128/Jvi.05154-11  1
2011 Jang JH, Schaffer DV, Shea LD. Engineering biomaterial systems to enhance viral vector gene delivery. Molecular Therapy : the Journal of the American Society of Gene Therapy. 19: 1407-15. PMID 21629221 DOI: 10.1038/Mt.2011.111  1
2011 Dalkara D, Kolstad KD, Guerin KI, Hoffmann NV, Visel M, Klimczak RR, Schaffer DV, Flannery JG. AAV mediated GDNF secretion from retinal glia slows down retinal degeneration in a rat model of retinitis pigmentosa. Molecular Therapy : the Journal of the American Society of Gene Therapy. 19: 1602-8. PMID 21522134 DOI: 10.1038/Mt.2011.62  1
2011 Arkin AP, Schaffer DV. Network news: innovations in 21st century systems biology. Cell. 144: 844-9. PMID 21414475 DOI: 10.1016/J.Cell.2011.03.008  1
2011 Chow EK, Zhang XQ, Chen M, Lam R, Robinson E, Huang H, Schaffer D, Osawa E, Goga A, Ho D. Nanodiamond therapeutic delivery agents mediate enhanced chemoresistant tumor treatment. Science Translational Medicine. 3: 73ra21. PMID 21389265 DOI: 10.1126/Scitranslmed.3001713  1
2011 Yin L, Greenberg K, Hunter JJ, Dalkara D, Kolstad KD, Masella BD, Wolfe R, Visel M, Stone D, Libby RT, Diloreto D, Schaffer D, Flannery J, Williams DR, Merigan WH. Intravitreal injection of AAV2 transduces macaque inner retina. Investigative Ophthalmology & Visual Science. 52: 2775-83. PMID 21310920 DOI: 10.1167/Iovs.10-6250  1
2011 Jang JH, Koerber JT, Kim JS, Asuri P, Vazin T, Bartel M, Keung A, Kwon I, Park KI, Schaffer DV. An evolved adeno-associated viral variant enhances gene delivery and gene targeting in neural stem cells. Molecular Therapy : the Journal of the American Society of Gene Therapy. 19: 667-75. PMID 21224831 DOI: 10.1038/Mt.2010.287  1
2011 Dickinson BC, Peltier J, Stone D, Schaffer DV, Chang CJ. Nox2 redox signaling maintains essential cell populations in the brain. Nature Chemical Biology. 7: 106-12. PMID 21186346 DOI: 10.1038/Nchembio.497  1
2011 Adnan A, Lam R, Chen H, Lee J, Schaffer DJ, Barnard AS, Schatz GC, Ho D, Liu WK. Atomistic simulation and measurement of pH dependent cancer therapeutic interactions with nanodiamond carrier. Molecular Pharmaceutics. 8: 368-74. PMID 21171586 DOI: 10.1021/Mp1002398  1
2011 Little LE, Dane KY, Daugherty PS, Healy KE, Schaffer DV. Exploiting bacterial peptide display technology to engineer biomaterials for neural stem cell culture. Biomaterials. 32: 1484-94. PMID 21129772 DOI: 10.1016/J.Biomaterials.2010.10.032  1
2011 Peltier J, Conway A, Keung AJ, Schaffer DV. Akt increases sox2 expression in adult hippocampal neural progenitor cells, but increased sox2 does not promote proliferation. Stem Cells and Development. 20: 1153-61. PMID 21028992 DOI: 10.1089/Scd.2010.0130  1
2011 Chen S, Patel N, Schaffer D, Maharbiz MM. Trap and corral: A two-step approach for constructing and constraining dynamic cell contact events in differentiating progenitor cell populations Journal of Micromechanics and Microengineering. 21. DOI: 10.1088/0960-1317/21/5/054027  1
2011 Willerth S, Schaffer D. Scaffold materials for hes cell culture and differentiation Comprehensive Biomaterials. 5: 95-113.  1
2011 Bergen J, Schaffer D. Engineering viruses for gene therapy Comprehensive Biomaterials. 2: 17-33.  1
2010 Saha K, Kim J, Irwin E, Yoon J, Momin F, Trujillo V, Schaffer DV, Healy KE, Hayward RC. Surface creasing instability of soft polyacrylamide cell culture substrates. Biophysical Journal. 99: L94-6. PMID 21156124 DOI: 10.1016/J.Bpj.2010.09.045  1
2010 Willerth SM, Pedro HA, Pachter L, Humeau LM, Arkin AP, Schaffer DV. Development of a low bias method for characterizing viral populations using next generation sequencing technology. Plos One. 5: e13564. PMID 21042592 DOI: 10.1371/Journal.Pone.0013564  1
2010 Darby SG, Moore MR, Friedlander TA, Schaffer DK, Reiserer RS, Wikswo JP, Seale KT. A metering rotary nanopump for microfluidic systems. Lab On a Chip. 10: 3218-26. PMID 20959938 DOI: 10.1039/C0Lc00087F  1
2010 Skupsky R, Burnett JC, Foley JE, Schaffer DV, Arkin AP. HIV promoter integration site primarily modulates transcriptional burst size rather than frequency. Plos Computational Biology. 6. PMID 20941390 DOI: 10.1371/Journal.Pcbi.1000952  1
2010 Punyadeera C, Schneider EM, Schaffer D, Hsu HY, Joos TO, Kriebel F, Weiss M, Verhaegh WF. Authors's reply. Journal of Emergencies, Trauma, and Shock. 3: 308. PMID 20931008  1
2010 Schaffer DJ, Tunc-Ozcan E, Shukla PK, Volenec A, Redei EE. Nuclear orphan receptor Nor-1 contributes to depressive behavior in the Wistar-Kyoto rat model of depression. Brain Research. 1362: 32-9. PMID 20851110 DOI: 10.1016/j.brainres.2010.09.041  1
2010 Keung AJ, Healy KE, Kumar S, Schaffer DV. Biophysics and dynamics of natural and engineered stem cell microenvironments. Wiley Interdisciplinary Reviews. Systems Biology and Medicine. 2: 49-64. PMID 20836010 DOI: 10.1002/Wsbm.46  1
2010 Schaffer DV. Microarraying for mechanosensivitity. Cell Stem Cell. 7: 273-4. PMID 20804961 DOI: 10.1016/J.Stem.2010.08.007  1
2010 Ananthanarayanan B, Little L, Schaffer DV, Healy KE, Tirrell M. Neural stem cell adhesion and proliferation on phospholipid bilayers functionalized with RGD peptides. Biomaterials. 31: 8706-15. PMID 20728935 DOI: 10.1016/J.Biomaterials.2010.07.104  1
2010 Aviran S, Shah PS, Schaffer DV, Arkin AP. Computational models of HIV-1 resistance to gene therapy elucidate therapy design principles. Plos Computational Biology. 6. PMID 20711350 DOI: 10.1371/Journal.Pcbi.1000883  1
2010 Lim KI, Klimczak R, Yu JH, Schaffer DV. Specific insertions of zinc finger domains into Gag-Pol yield engineered retroviral vectors with selective integration properties. Proceedings of the National Academy of Sciences of the United States of America. 107: 12475-80. PMID 20616052 DOI: 10.1073/Pnas.1001402107  1
2010 Keung AJ, Kumar S, Schaffer DV. Presentation counts: microenvironmental regulation of stem cells by biophysical and material cues. Annual Review of Cell and Developmental Biology. 26: 533-56. PMID 20590452 DOI: 10.1146/Annurev-Cellbio-100109-104042  1
2010 Shah PS, Schaffer DV. Gene therapy takes a cue from HAART: combinatorial antiviral therapeutics reach the clinic. Science Translational Medicine. 2: 36ps30. PMID 20555021 DOI: 10.1126/Scitranslmed.3001298  1
2010 Jang JH, Koerber JT, Gujraty K, Bethi SR, Kane RS, Schaffer DV. Surface immobilization of hexa-histidine-tagged adeno-associated viral vectors for localized gene delivery. Gene Therapy. 17: 1384-9. PMID 20508598 DOI: 10.1038/Gt.2010.81  1
2010 Markov DA, Samson PC, Schaffer DK, Dhummakupt A, Wikswo JP, Shor LM. Window on a microworld: simple microfluidic systems for studying microbial transport in porous media. Journal of Visualized Experiments : Jove. PMID 20440259 DOI: 10.3791/1741  1
2010 Peltier J, Schaffer DV. Viral packaging and transduction of adult hippocampal neural progenitors. Methods in Molecular Biology (Clifton, N.J.). 621: 103-16. PMID 20405362 DOI: 10.1007/978-1-60761-063-2_7  1
2010 Robertson MJ, Peltier J, Schaffer DV. In vivo analysis of engrafted adult hippocampal neural progenitors. Methods in Molecular Biology (Clifton, N.J.). 621: 89-102. PMID 20405361 DOI: 10.1007/978-1-60761-063-2_6  1
2010 Peltier J, Agrawal S, Robertson MJ, Schaffer DV. In vitro culture and analysis of adult hippocampal neural progenitors. Methods in Molecular Biology (Clifton, N.J.). 621: 65-87. PMID 20405360 DOI: 10.1007/978-1-60761-063-2_5  1
2010 Peltier J, Ormerod BK, Schaffer DV. Isolation of adult hippocampal neural progenitors. Methods in Molecular Biology (Clifton, N.J.). 621: 57-63. PMID 20405359 DOI: 10.1007/978-1-60761-063-2_4  1
2010 Burnett JC, Lim KI, Calafi A, Rossi JJ, Schaffer DV, Arkin AP. Combinatorial latency reactivation for HIV-1 subtypes and variants. Journal of Virology. 84: 5958-74. PMID 20357084 DOI: 10.1128/Jvi.00161-10  1
2010 Punyadeera C, Schneider EM, Schaffer D, Hsu HY, Joos TO, Kriebel F, Weiss M, Verhaegh WF. A biomarker panel to discriminate between systemic inflammatory response syndrome and sepsis and sepsis severity. Journal of Emergencies, Trauma, and Shock. 3: 26-35. PMID 20165718 DOI: 10.4103/0974-2700.58666  1
2010 Kurpinski K, Lam H, Chu J, Wang A, Kim A, Tsay E, Agrawal S, Schaffer DV, Li S. Transforming growth factor-beta and notch signaling mediate stem cell differentiation into smooth muscle cells. Stem Cells (Dayton, Ohio). 28: 734-42. PMID 20146266 DOI: 10.1002/Stem.319  1
2010 Vazin T, Schaffer DV. Engineering strategies to emulate the stem cell niche. Trends in Biotechnology. 28: 117-24. PMID 20042248 DOI: 10.1016/J.Tibtech.2009.11.008  1
2010 Kolstad KD, Dalkara D, Guerin K, Visel M, Hoffmann N, Schaffer DV, Flannery JG. Changes in adeno-associated virus-mediated gene delivery in retinal degeneration. Human Gene Therapy. 21: 571-8. PMID 20021232 DOI: 10.1089/Hum.2009.194  1
2010 Shukla PK, Sittig LJ, Andrus BM, Schaffer DJ, Batra KK, Redei EE. Prenatal thyroxine treatment disparately affects peripheral and amygdala thyroid hormone levels. Psychoneuroendocrinology. 35: 791-7. PMID 20005050 DOI: 10.1016/J.Psyneuen.2009.10.019  1
2010 Peltier J, Schaffer DV. Systems biology approaches to understanding stem cell fate choice. Iet Systems Biology. 4: 1-11. PMID 20001088 DOI: 10.1049/Iet-Syb.2009.0011  1
2010 Meng Y, Eshghi S, Li YJ, Schmidt R, Schaffer DV, Healy KE. Characterization of integrin engagement during defined human embryonic stem cell culture. Faseb Journal : Official Publication of the Federation of American Societies For Experimental Biology. 24: 1056-65. PMID 19933311 DOI: 10.1096/Fj.08-126821  1
2009 Klimczak RR, Koerber JT, Dalkara D, Flannery JG, Schaffer DV. A novel adeno-associated viral variant for efficient and selective intravitreal transduction of rat Müller cells. Plos One. 4: e7467. PMID 19826483 DOI: 10.1371/Journal.Pone.0007467  1
2009 Carlson ME, Conboy MJ, Hsu M, Barchas L, Jeong J, Agrawal A, Mikels AJ, Agrawal S, Schaffer DV, Conboy IM. Relative roles of TGF-beta1 and Wnt in the systemic regulation and aging of satellite cell responses. Aging Cell. 8: 676-89. PMID 19732043 DOI: 10.1111/J.1474-9726.2009.00517.X  1
2009 Dalkara D, Kolstad KD, Caporale N, Visel M, Klimczak RR, Schaffer DV, Flannery JG. Inner limiting membrane barriers to AAV-mediated retinal transduction from the vitreous. Molecular Therapy : the Journal of the American Society of Gene Therapy. 17: 2096-102. PMID 19672248 DOI: 10.1038/Mt.2009.181  1
2009 Koerber JT, Klimczak R, Jang JH, Dalkara D, Flannery JG, Schaffer DV. Molecular evolution of adeno-associated virus for enhanced glial gene delivery. Molecular Therapy : the Journal of the American Society of Gene Therapy. 17: 2088-95. PMID 19672246 DOI: 10.1038/Mt.2009.184  1
2009 Banerjee A, Arha M, Choudhary S, Ashton RS, Bhatia SR, Schaffer DV, Kane RS. The influence of hydrogel modulus on the proliferation and differentiation of encapsulated neural stem cells. Biomaterials. 30: 4695-9. PMID 19539367 DOI: 10.1016/J.Biomaterials.2009.05.050  1
2009 Agrawal S, Archer C, Schaffer DV. Computational models of the Notch network elucidate mechanisms of context-dependent signaling. Plos Computational Biology. 5: e1000390. PMID 19468305 DOI: 10.1371/Journal.Pcbi.1000390  1
2009 Schaffer D. A lesson or two from a regional economic argument. Nature. 458: 1101. PMID 19407773 DOI: 10.1038/4581101b  0.12
2009 Excoffon KJ, Koerber JT, Dickey DD, Murtha M, Keshavjee S, Kaspar BK, Zabner J, Schaffer DV. Directed evolution of adeno-associated virus to an infectious respiratory virus. Proceedings of the National Academy of Sciences of the United States of America. 106: 3865-70. PMID 19237554 DOI: 10.1073/Pnas.0813365106  1
2009 Burnett JC, Miller-Jensen K, Shah PS, Arkin AP, Schaffer DV. Control of stochastic gene expression by host factors at the HIV promoter. Plos Pathogens. 5: e1000260. PMID 19132086 DOI: 10.1371/Journal.Ppat.1000260  1
2009 Wang G, Auerbach A, Wei M, Dow N, Barry TS, Hodge L, Schaffer D, Sobin LH, Aguilera NS. t(11;18)(q21;q21) in extranodal marginal zone B-cell lymphoma of mucosa-associated lymphoid tissue in stomach: a study of 48 cases. Modern Pathology : An Official Journal of the United States and Canadian Academy of Pathology, Inc. 22: 79-86. PMID 18820661 DOI: 10.1038/modpathol.2008.155  1
2008 Eshghi S, Schaffer DV. Engineering microenvironments to control stem cell fate and function Stembook. PMID 20614608 DOI: 10.3824/Stembook.1.5.1  1
2008 Leonard JN, Shah PS, Burnett JC, Schaffer DV. HIV evades RNA interference directed at TAR by an indirect compensatory mechanism. Cell Host & Microbe. 4: 484-94. PMID 18996348 DOI: 10.1016/J.Chom.2008.09.008  1
2008 Faley S, Seale K, Hughey J, Schaffer DK, VanCompernolle S, McKinney B, Baudenbacher F, Unutmaz D, Wikswo JP. Microfluidic platform for real-time signaling analysis of multiple single T cells in parallel. Lab On a Chip. 8: 1700-12. PMID 18813394 DOI: 10.1039/B719799C  1
2008 Koerber JT, Jang JH, Schaffer DV. DNA shuffling of adeno-associated virus yields functionally diverse viral progeny. Molecular Therapy : the Journal of the American Society of Gene Therapy. 16: 1703-9. PMID 18728640 DOI: 10.1038/Mt.2008.167  1
2008 Saha K, Keung AJ, Irwin EF, Li Y, Little L, Schaffer DV, Healy KE. Substrate modulus directs neural stem cell behavior. Biophysical Journal. 95: 4426-38. PMID 18658232 DOI: 10.1529/Biophysj.108.132217  1
2008 Schaffer DV, Koerber JT, Lim KI. Molecular engineering of viral gene delivery vehicles. Annual Review of Biomedical Engineering. 10: 169-94. PMID 18647114 DOI: 10.1146/Annurev.Bioeng.10.061807.160514  1
2008 Little L, Healy KE, Schaffer D. Engineering biomaterials for synthetic neural stem cell microenvironments. Chemical Reviews. 108: 1787-96. PMID 18476674 DOI: 10.1021/Cr078228T  1
2008 Koerber JT, Schaffer DV. Transposon-based mutagenesis generates diverse adeno-associated viral libraries with novel gene delivery properties. Methods in Molecular Biology (Clifton, N.J.). 434: 161-70. PMID 18470644 DOI: 10.1007/978-1-60327-248-3_10  1
2008 Wall ST, Saha K, Ashton RS, Kam KR, Schaffer DV, Healy KE. Multivalency of Sonic hedgehog conjugated to linear polymer chains modulates protein potency. Bioconjugate Chemistry. 19: 806-12. PMID 18380472 DOI: 10.1021/Bc700265K  1
2008 Lim KI, Schaffer DV. Library selection approaches to engineering enhanced retroviral and lentiviral vectors. Combinatorial Chemistry & High Throughput Screening. 11: 111-7. PMID 18336204 DOI: 10.2174/138620708783744444  1
2008 Ricci C, Pastukh V, Leonard J, Turrens J, Wilson G, Schaffer D, Schaffer SW. Mitochondrial DNA damage triggers mitochondrial-superoxide generation and apoptosis. American Journal of Physiology. Cell Physiology. 294: C413-22. PMID 18077603 DOI: 10.1152/Ajpcell.00362.2007  1
2008 Robertson MJ, Gip P, Schaffer DV. Neural stem cell engineering: directed differentiation of adult and embryonic stem cells into neurons. Frontiers in Bioscience : a Journal and Virtual Library. 13: 21-50. PMID 17981526 DOI: 10.2741/2558  1
2008 Kwon I, Schaffer DV. Designer gene delivery vectors: molecular engineering and evolution of adeno-associated viral vectors for enhanced gene transfer. Pharmaceutical Research. 25: 489-99. PMID 17763830 DOI: 10.1007/S11095-007-9431-0  1
2008 Miller-Jensen K, Lauffenburger DA, Schaffer DV. Systems biology approaches to studying intracellular signaling interactions between virus and host Aiche Annual Meeting, Conference Proceedings 1
2008 Koerber JT, Excoffon K, Kaspar B, Zabner J, Schaffer DV. Engineering of a novel AAV vector in a human airway model system for cystic fibrosis gene therapy Aiche Annual Meeting, Conference Proceedings 1
2008 Kwon I, Koerber JT, Schaffer DV. Directed evolution of AAV to target tissue-specific vascular endothelium Aiche Annual Meeting, Conference Proceedings 1
2008 Koerber JT, Schaffer DV. A rapid, general platform to identify structure/function relationships of a viral protein Aiche Annual Meeting, Conference Proceedings 1
2007 Schaffer D. Exploring and Engineering Stem Cells and their Niches. Current Opinion in Chemical Biology. 11: 355-356. PMID 18670582 DOI: 10.1016/J.Cbpa.2007.07.001  0.12
2007 Ashton RS, Banerjee A, Punyani S, Schaffer DV, Kane RS. Scaffolds based on degradable alginate hydrogels and poly(lactide-co-glycolide) microspheres for stem cell culture. Biomaterials. 28: 5518-25. PMID 17881048 DOI: 10.1016/J.Biomaterials.2007.08.038  1
2007 Ashton RS, Peltier J, Fasano CA, O'Neill A, Leonard J, Temple S, Schaffer DV, Kane RS. High-throughput screening of gene function in stem cells using clonal microarrays. Stem Cells (Dayton, Ohio). 25: 2928-35. PMID 17673524 DOI: 10.1634/Stemcells.2007-0468  1
2007 Saha K, Pollock JF, Schaffer DV, Healy KE. Designing synthetic materials to control stem cell phenotype. Current Opinion in Chemical Biology. 11: 381-7. PMID 17669680 DOI: 10.1016/J.Cbpa.2007.05.030  1
2007 Peltier J, O'Neill A, Schaffer DV. PI3K/Akt and CREB regulate adult neural hippocampal progenitor proliferation and differentiation. Developmental Neurobiology. 67: 1348-61. PMID 17638387 DOI: 10.1002/Dneu.20506  1
2007 Jang JH, Lim KI, Schaffer DV. Library selection and directed evolution approaches to engineering targeted viral vectors. Biotechnology and Bioengineering. 98: 515-24. PMID 17614321 DOI: 10.1002/Bit.21541  1
2007 Ho JE, Chung EH, Wall S, Schaffer DV, Healy KE. Immobilized sonic hedgehog N-terminal signaling domain enhances differentiation of bone marrow-derived mesenchymal stem cells. Journal of Biomedical Materials Research. Part A. 83: 1200-8. PMID 17600327 DOI: 10.1002/Jbm.A.31355  1
2007 Koerber JT, Jang JH, Yu JH, Kane RS, Schaffer DV. Engineering adeno-associated virus for one-step purification via immobilized metal affinity chromatography. Human Gene Therapy. 18: 367-78. PMID 17437357 DOI: 10.1089/Hum.2006.139  1
2007 Greenberg KP, Geller SF, Schaffer DV, Flannery JG. Targeted transgene expression in muller glia of normal and diseased retinas using lentiviral vectors. Investigative Ophthalmology & Visual Science. 48: 1844-52. PMID 17389520 DOI: 10.1167/Iovs.05-1570  1
2007 Schäffer DA, Gábriel R. GABA-immunoreactive photoreceptors in the retina of an anuran, Pelobates fuscus. Neuroscience Letters. 416: 202-5. PMID 17349745 DOI: 10.1016/j.neulet.2007.02.009  1
2007 Leonard JN, Ferstl P, Delgado A, Schaffer DV. Enhanced preparation of adeno-associated viral vectors by using high hydrostatic pressure to selectively inactivate helper adenovirus. Biotechnology and Bioengineering. 97: 1170-9. PMID 17252611 DOI: 10.1002/Bit.21355  1
2007 Saha K, Irwin EF, Kozhukh J, Schaffer DV, Healy KE. Biomimetic interfacial interpenetrating polymer networks control neural stem cell behavior. Journal of Biomedical Materials Research. Part A. 81: 240-9. PMID 17236216 DOI: 10.1002/Jbm.A.30986  1
2006 Koerber JT, Maheshri N, Kaspar BK, Schaffer DV. Construction of diverse adeno-associated viral libraries for directed evolution of enhanced gene delivery vehicles. Nature Protocols. 1: 701-6. PMID 17406299 DOI: 10.1038/Nprot.2006.93  1
2006 Greenberg KP, Lee ES, Schaffer DV, Flannery JG. Gene delivery to the retina using lentiviral vectors. Advances in Experimental Medicine and Biology. 572: 255-66. PMID 17249582 DOI: 10.1007/0-387-32442-9_36  1
2006 Schaffer D, Florin T, Eagle C, Marschner I, Singh G, Grobler M, Fenn C, Schou M, Curnow KM. Risk of serious NSAID-related gastrointestinal events during long-term exposure: a systematic review. The Medical Journal of Australia. 185: 501-6. PMID 17137455  1
2006 Yu JH, Schaffer DV. High-throughput, library-based selection of a murine leukemia virus variant to infect nondividing cells. Journal of Virology. 80: 8981-8. PMID 16940510 DOI: 10.1128/Jvi.00615-06  1
2006 Jang JH, Schaffer DV. Microarraying the cellular microenvironment. Molecular Systems Biology. 2: 39. PMID 16820780 DOI: 10.1038/Msb4100079  1
2006 Enger SM, Van den Eeden SK, Sternfeld B, Loo RK, Quesenberry CP, Rowell S, Sadler MC, Schaffer DM, Habel LA, Caan BJ. California Men's Health Study (CMHS): a multiethnic cohort in a managed care setting. Bmc Public Health. 6: 172. PMID 16813653 DOI: 10.1186/1471-2458-6-172  1
2006 Velie EM, Shaw GM, Malcoe LH, Schaffer DM, Samuels SJ, Todoroff K, Block G. Understanding the increased risk of neural tube defect-affected pregnancies among Mexico-born women in California: immigration and anthropometric factors. Paediatric and Perinatal Epidemiology. 20: 219-30. PMID 16629696 DOI: 10.1111/J.1365-3016.2006.00722.X  1
2006 Yu JH, Schaffer DV. Selection of novel vesicular stomatitis virus glycoprotein variants from a peptide insertion library for enhanced purification of retroviral and lentiviral vectors. Journal of Virology. 80: 3285-92. PMID 16537595 DOI: 10.1128/Jvi.80.7.3285-3292.2006  1
2006 Saha K, Schaffer DV. Signal dynamics in Sonic hedgehog tissue patterning. Development (Cambridge, England). 133: 889-900. PMID 16452094 DOI: 10.1242/Dev.02254  1
2006 Maheshri N, Koerber JT, Kaspar BK, Schaffer DV. Directed evolution of adeno-associated virus yields enhanced gene delivery vectors. Nature Biotechnology. 24: 198-204. PMID 16429148 DOI: 10.1038/Nbt1182  1
2006 Abranches E, O'Neill A, Robertson MJ, Schaffer DV, Cabral JM. Development of quantitative PCR methods to analyse neural progenitor cell culture state. Biotechnology and Applied Biochemistry. 44: 1-8. PMID 16336211 DOI: 10.1042/Ba20050218  1
2006 Leonard JN, Schaffer DV. Antiviral RNAi therapy: emerging approaches for hitting a moving target. Gene Therapy. 13: 532-40. PMID 16177819 DOI: 10.1038/Sj.Gt.3302645  1
2005 Yu JH, Schaffer DV. Advanced targeting strategies for murine retroviral and adeno-associated viral vectors. Advances in Biochemical Engineering/Biotechnology. 99: 147-67. PMID 16568891 DOI: 10.1007/10_006  1
2005 Weinberger LS, Burnett JC, Toettcher JE, Arkin AP, Schaffer DV. Stochastic gene expression in a lentiviral positive-feedback loop: HIV-1 Tat fluctuations drive phenotypic diversity. Cell. 122: 169-82. PMID 16051143 DOI: 10.1016/J.Cell.2005.06.006  1
2005 Ges IA, Ivanov BL, Schaffer DK, Lima EA, Werdich AA, Baudenbacher FJ. Thin-film IrOx pH microelectrode for microfluidic-based microsystems. Biosensors & Bioelectronics. 21: 248-56. PMID 16023951 DOI: 10.1016/J.Bios.2004.09.021  0.01
2005 Schäffer DA, Gábriel R. Two major tachykinins, substance P and substance K, are localized to distinct subsets of amacrine cells in the anuran retina. Neuroscience Letters. 386: 194-8. PMID 16005149 DOI: 10.1016/j.neulet.2005.06.011  1
2005 Lee GK, Maheshri N, Kaspar B, Schaffer DV. PEG conjugation moderately protects adeno-associated viral vectors against antibody neutralization. Biotechnology and Bioengineering. 92: 24-34. PMID 15937953 DOI: 10.1002/Bit.20562  1
2005 Shaw GM, Carmichael SL, Yang W, Schaffer DM. Periconceptional dietary intake of myo-inositol and neural tube defects in offspring. Birth Defects Research. Part a, Clinical and Molecular Teratology. 73: 184-7. PMID 15744734 DOI: 10.1002/Bdra.20112  1
2005 Gordon NP, Schaffer DM. Use of dietary supplements by female seniors in a large Northern California health plan. Bmc Geriatrics. 5: 4. PMID 15703066 DOI: 10.1186/1471-2318-5-4  0.01
2005 Agrawal S, Schaffer DV. In situ stem cell therapy: novel targets, familiar challenges. Trends in Biotechnology. 23: 78-83. PMID 15661344 DOI: 10.1016/J.Tibtech.2004.12.004  1
2005 Leonard JN, Schaffer DV. Computational design of antiviral RNA interference strategies that resist human immunodeficiency virus escape. Journal of Virology. 79: 1645-54. PMID 15650190 DOI: 10.1128/Jvi.79.3.1645-1654.2005  1
2005 Koerber JT, Maheshri N, Kaspar B, Schaffer DV. 1085. Directed Evolution of AAV2 Leads to Improved Viral Function Molecular Therapy. 11. DOI: 10.1016/J.Ymthe.2005.07.632  1
2005 Leonard JN, Schaffer DV. 1002. Therapeutic Design Principles for Achieving Long-Term Suppression of HIV-1 with RNA Interference Molecular Therapy. 11. DOI: 10.1016/J.Ymthe.2005.07.549  1
2005 Leonard JN, Schaffer DV, Ferstl P, Delgado A. 519. Selective Inactivation of Helper Adenovirus with High Hydrostatic Pressure for AAV-2 Vector Production Molecular Therapy. 11. DOI: 10.1016/J.Ymthe.2005.07.059  1
2005 Yu JH, Schaffer DV. 488. Engineering Enhanced Retroviral Vectors through the Insertion of a His6 Tag into VSV-G Molecular Therapy. 11. DOI: 10.1016/J.Ymthe.2005.07.028  1
2005 Schaffer DV, Zhou W. Gene therapy and gene delivery systems as future human therapeutics Advances in Biochemical Engineering/Biotechnology. 99: 1-5. DOI: 10.1007/10_001  1
2005 Weinberger LS, Burnett JC, Toettcher JE, Arkin AP, Schaffer DV. Stochastic gene expression in a lentiviral positive feedback loop: HIV-1 tat fluctuations drive phenotypic diversity Aiche Annual Meeting, Conference Proceedings. 10416.  1
2005 Leonard JN, Schaffer DV. Computational design of RNA interference gene therapy strategies to treat HIV-1 infections and block viral escape Aiche Annual Meeting, Conference Proceedings. 8356-8357.  1
2005 Koerber JT, Maheshri N, Schaffer DV. Directed evolution of Aav to generate mutants with enhanced transport properties Aiche Annual Meeting, Conference Proceedings. 8565.  1
2005 Yu JH, Schaffer DV. Engineering enhanced retroviral vectors for gene therapy Through the generation and selection of 6xhis peptide insertion libraries into Vsv-G Aiche Annual Meeting, Conference Proceedings. 8084.  1
2005 Leonard JN, Ferstl P, Delgado A, Schaffer DV. Purification of Aav gene therapy vectors by selectively inactivating helper adenovirus using high hydrostatic pressure Aiche Annual Meeting, Conference Proceedings. 12143.  1
2004 Schaffer DV, O'Neill A, Hochrein L, McGranahan T. Quantitative analysis of signaling mechanisms controlling adult neural progenitor cell proliferation. Conference Proceedings : ... Annual International Conference of the Ieee Engineering in Medicine and Biology Society. Ieee Engineering in Medicine and Biology Society. Annual Conference. 7: 4965. PMID 17271428 DOI: 10.1109/IEMBS.2004.1404372  1
2004 Schaffer DV, Maheshri N. Directed evolution of AAV mutants for enhanced gene delivery. Conference Proceedings : ... Annual International Conference of the Ieee Engineering in Medicine and Biology Society. Ieee Engineering in Medicine and Biology Society. Annual Conference. 5: 3520-3. PMID 17271049 DOI: 10.1109/IEMBS.2004.1403990  1
2004 Prokop A, Prokop Z, Schaffer D, Kozlov E, Wikswo J, Cliffel D, Baudenbacher F. NanoLiterBioReactor: long-term mammalian cell culture at nanofabricated scale. Biomedical Microdevices. 6: 325-39. PMID 15548879 DOI: 10.1023/B:Bmmd.0000048564.37800.D6  1
2004 Fenn GC, Grobler M, Schaffer D. Impact of selective cyclooxygenase-2 inhibitors on anti-ulcer medication and non-steroidal anti-inflammatory drug use in patients with rheumatic disease. Internal Medicine Journal. 34: 647-9; discussion 65. PMID 15546461 DOI: 10.1111/j.1445-5994.2004.00683.x  1
2004 O'Neill A, Schaffer DV. The biology and engineering of stem-cell control. Biotechnology and Applied Biochemistry. 40: 5-16. PMID 15270702 DOI: 10.1042/Ba20030195  1
2004 Shaw GM, Carmichael SL, Yang W, Selvin S, Schaffer DM. Periconceptional dietary intake of choline and betaine and neural tube defects in offspring. American Journal of Epidemiology. 160: 102-9. PMID 15234930 DOI: 10.1093/Aje/Kwh187  1
2004 Ignowski JM, Schaffer DV. Kinetic analysis and modeling of firefly luciferase as a quantitative reporter gene in live mammalian cells. Biotechnology and Bioengineering. 86: 827-34. PMID 15162459 DOI: 10.1002/Bit.20059  1
2004 Lai K, Robertson MJ, Schaffer DV. The sonic hedgehog signaling system as a bistable genetic switch. Biophysical Journal. 86: 2748-57. PMID 15111393 DOI: 10.1016/S0006-3495(04)74328-3  1
2004 Schaffer DV, Gage FH. Neurogenesis and neuroadaptation. Neuromolecular Medicine. 5: 1-9. PMID 15001808 DOI: 10.1385/Nmm:5:1:001  1
2004 Yu JH, Schaffer DV. 725. Engineering Enhanced Retroviral Vectors by Random Insertion of Functional Peptides Molecular Therapy. 9. DOI: 10.1016/J.Ymthe.2004.06.654  1
2004 Leonard JN, Schaffer DV. 547. Antiviral RNA Interference Strategies That Resist HIV Escape Molecular Therapy. 9. DOI: 10.1016/J.Ymthe.2004.06.463  1
2004 Lee GK, Schaffer DV. 401. Engineering Retroviral Vectors for Stem Cell Therapies-Overcoming the Effect of Gene Silencing Molecular Therapy. 9. DOI: 10.1016/J.Ymthe.2004.06.350  1
2004 Maheshri N, Kaspar B, Schaffer DV. 20. Directed Evolution of AAV2 Yields Novel Capsid Variants Molecular Therapy. 9. DOI: 10.1016/J.Ymthe.2004.05.101  1
2003 Weinberger LS, Schaffer DV, Arkin AP. Theoretical design of a gene therapy to prevent AIDS but not human immunodeficiency virus type 1 infection. Journal of Virology. 77: 10028-36. PMID 12941913 DOI: 10.1128/Jvi.77.18.10028-10036.2003  1
2003 Maheshri N, Schaffer DV. Computational and experimental analysis of DNA shuffling. Proceedings of the National Academy of Sciences of the United States of America. 100: 3071-6. PMID 12626764 DOI: 10.1073/Pnas.0537968100  1
2003 Lai K, Kaspar BK, Gage FH, Schaffer DV. Sonic hedgehog regulates adult neural progenitor proliferation in vitro and in vivo. Nature Neuroscience. 6: 21-7. PMID 12469128 DOI: 10.1038/Nn983  1
2002 Lee G, Schaffer D. Engineering the surface properties of synthetic gene delivery vectors Somatic Cell and Molecular Genetics. 27: 17-25. PMID 12774938 DOI: 10.1023/A:1022940100090  1
2002 Bonadio J, Woo SL, High K, Ghivizzani S, Schaffer D. Genetic approaches to tissue engineering: breakout session summary. Annals of the New York Academy of Sciences. 961: 71-2. PMID 12081869 DOI: 10.1111/J.1749-6632.2002.Tb03053.X  1
2002 Schaffer DV. Genetic approaches to tissue repair. Annals of the New York Academy of Sciences. 961: 68-70. PMID 12081868 DOI: 10.1111/J.1749-6632.2002.Tb03052.X  1
2002 Kaspar BK, Vissel B, Bengoechea T, Crone S, Randolph-Moore L, Muller R, Brandon EP, Schaffer D, Verma IM, Lee KF, Heinemann SF, Gage FH. Adeno-associated virus effectively mediates conditional gene modification in the brain. Proceedings of the National Academy of Sciences of the United States of America. 99: 2320-5. PMID 11842206 DOI: 10.1073/Pnas.042678699  1
2002 Wiewrodt R, Thomas AP, Cipelletti L, Christofidou-Solomidou M, Weitz DA, Feinstein SI, Schaffer D, Albelda SM, Koval M, Muzykantov VR. Size-dependent intracellular immunotargeting of therapeutic cargoes into endothelial cells. Blood. 99: 912-22. PMID 11806994 DOI: 10.1182/Blood.V99.3.912  0.01
2002 Kaspar BK, Erickson D, Schaffer D, Hinh L, Gage FH, Peterson DA. Targeted retrograde gene delivery for neuronal protection. Molecular Therapy : the Journal of the American Society of Gene Therapy. 5: 50-6. PMID 11786045 DOI: 10.1006/mthe.2001.0520  1
2001 Mozaffari MS, Schaffer D. Taurine modulates arginine vasopressin-mediated regulation of renal function. Journal of Cardiovascular Pharmacology. 37: 742-750. PMID 11392471 DOI: 10.1097/00005344-200106000-00012  0.08
2000 Schaffer DV, Lauffenburger DA. Targeted synthetic gene delivery vectors. Current Opinion in Molecular Therapeutics. 2: 155-61. PMID 11249636  1
2000 Schaffer DV, Fidelman NA, Dan N, Lauffenburger DA. Vector unpacking as a potential barrier for receptor-mediated polyplex gene delivery. Biotechnology and Bioengineering. 67: 598-606. PMID 10649234 DOI: 10.1002/(Sici)1097-0290(20000305)67:5<598::Aid-Bit10>3.0.Co;2-G  1
1999 Lauffenburger DA, Schaffer DV. The matrix delivers. Nature Medicine. 5: 733-4. PMID 10395312 DOI: 10.1038/10451  1
1998 Schaffer DV, Lauffenburger DA. Optimization of cell surface binding enhances efficiency and specificity of molecular conjugate gene delivery. The Journal of Biological Chemistry. 273: 28004-9. PMID 9774415 DOI: 10.1074/Jbc.273.43.28004  1
1997 Schaffer DV, Neve RL, Lauffenburger DA. Use of the green fluorescent protein as a quantitative reporter of epidermal growth factor receptor-mediated gene delivery Tissue Engineering. 3: 53-63. DOI: 10.1089/Ten.1997.3.53  1
1994 Gramer MJ, Schaffer DV, Sliwkowski MB, Goochee CF. Purification and characterization of alpha-L-fucosidase from Chinese hamster ovary cell culture supernatant. Glycobiology. 4: 611-6. PMID 7881175 DOI: 10.1093/glycob/4.5.611  1
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