Bruce Tidor
Affiliations: | Biological Engineering | Massachusetts Institute of Technology, Cambridge, MA, United States |
Area:
structure and properties of proteins, nucleic acids, and their complexesWebsite:
http://web.mit.edu/be/people/tidor.shtmlGoogle:
"Bruce Tidor"Bio:
http://groups.csail.mit.edu/tidor/
Bruce Tidor received his Ph.D. (1990) in Biophysics from Harvard University under the supervision of Professor Martin Karplus, where he studied protein folding and binding with free energy simulations and normal mode calculations. In 1990 he moved to the Whitehead Institute for Biomedical Research, where he started his independent research as a Whitehead Fellow. In 1994 he was appointed to the faculty at MIT. He is currently Professor of Biological Engineering and Computer Science. His research focuses on the analysis of complex biological systems at the molecular and cellular level. Using molecular modeling, theory, and computation, he explores the structure, function, and interactions of proteins and the roles played by specific chemical groups in defining the stability and specificity of molecular interactions. Using cell-level models his group is exploring the relationship between network structure and biological function. He is actively applying knowledge from modeling studies to rational design.
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Mean distance: 7.46 | S | N | B | C | P |
Parents
Sign in to add mentor| Martin Karplus | grad student | 1990 | Harvard | |
| (Molecular modeling of contributions to free energy changes: Applications to proteins) | ||||
Children
Sign in to add trainee| Lillian T. Chong | research assistant | 1995-1997 | MIT |
| David F. Green | grad student | 1997-2002 | |
| Lisa C. Tucker-Kellogg | grad student | 2000-2002 | (Neurotree) |
| Mark Bathe | grad student | 2001-2004 | MIT |
| Brian A. Joughin | grad student | 2001-2006 | MIT |
| Mala L. Radhakrishnan | grad student | 2007 | MIT |
| David J. Huggins | post-doc | MIT | |
| Amy E. Keating | post-doc | 2002 | MIT |
| Alessandro Senes | post-doc | 2001-2003 | MIT |
| Kelly Marie Thayer | post-doc | 2007-2009 | MIT |
| Devanathan Raghunathan | post-doc | 2010-2012 | MIT |
| sudipta samanta | research scientist | 2012-2016 | MIT |
Publications
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| Traxlmayr MW, Kiefer JD, Srinivas RR, et al. (2016) Strong Enrichment of Aromatic Residues in Binding Sites from a Charge-Neutralized Hyperthermostable Sso7d Scaffold Library. The Journal of Biological Chemistry |
| Shen Y, Radhakrishnan ML, Tidor B. (2015) Molecular mechanisms and design principles for promiscuous inhibitors to avoid drug resistance: lessons learned from HIV-1 protease inhibition. Proteins. 83: 351-72 |
| Shen Y, Radhakrishnan ML, Tidor B. (2015) Molecular mechanisms and design principles for promiscuous inhibitors to avoid drug resistance: Lessons learned from HIV-1 protease inhibition Proteins: Structure, Function and Bioinformatics. 83: 351-372 |
| Silver NW, King BM, Nalam MN, et al. (2013) Efficient Computation of Small-Molecule Configurational Binding Entropy and Free Energy Changes by Ensemble Enumeration. Journal of Chemical Theory and Computation. 9: 5098-5115 |
| Nalam MN, Ali A, Reddy GS, et al. (2013) Substrate envelope-designed potent HIV-1 protease inhibitors to avoid drug resistance. Chemistry & Biology. 20: 1116-24 |
| Shen Y, Altman MD, Ali A, et al. (2013) Testing the substrate-envelope hypothesis with designed pairs of compounds. Acs Chemical Biology. 8: 2433-41 |
| Shen Y, Gilson MK, Tidor B. (2012) Charge Optimization Theory for Induced-Fit Ligands. Journal of Chemical Theory and Computation. 8: 4580-4592 |
| Parai MK, Huggins DJ, Cao H, et al. (2012) Design, synthesis, and biological and structural evaluations of novel HIV-1 protease inhibitors to combat drug resistance. Journal of Medicinal Chemistry. 55: 6328-41 |
| Huggins DJ, Sherman W, Tidor B. (2012) Rational approaches to improving selectivity in drug design Journal of Medicinal Chemistry. 55: 1424-1444 |
| King BM, Silver NW, Tidor B. (2012) Efficient calculation of molecular configurational entropies using an information theoretic approximation. The Journal of Physical Chemistry. B. 116: 2891-904 |