Raquel L. Lieberman, Ph.D. - Publications

Affiliations: 
Northwestern University, Evanston, IL 
 Chemistry and Biochemistry Georgia Institute of Technology, Atlanta, GA 
Area:
bionorganic chemistry, protein crystallography
Website:
https://www.chemistry.gatech.edu/faculty/lieberman/

50 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2019 Hill SE, Cho H, Raut P, Lieberman RL. Calcium-ligand variants of the myocilin olfactomedin propeller selected from invertebrate phyla reveal cross-talk with N-terminal blade and surface helices. Acta Crystallographica. Section D, Structural Biology. 75: 817-824. PMID 31478904 DOI: 10.1107/S205979831901074X  1
2019 Hill SE, Kwon MS, Martin MD, Suntharalingam A, Hazel A, Dickey CA, Gumbart JC, Lieberman RL. Stable calcium-free myocilin olfactomedin domain variants reveal challenges in differentiating between benign and glaucoma-causing mutations. The Journal of Biological Chemistry. PMID 31270212 DOI: 10.1074/jbc.RA119.009419  1
2019 Patterson-Orazem AC, Hill SE, Wang Y, Dominic IM, Hall CK, Lieberman RL. Differential misfolding properties of glaucoma-associated olfactomedin domains from human and mouse. Biochemistry. PMID 30802039 DOI: 10.1021/acs.biochem.8b01309  1
2018 Patterson-Orazem AC, Hill SE, Fautsch MP, Lieberman RL. Epitope mapping of commercial antibodies that detect myocilin. Experimental Eye Research. PMID 29752947 DOI: 10.1016/j.exer.2018.05.002  1
2018 Wang Y, Gao Y, Hill SE, Huard DJE, Tomlin MO, Lieberman RL, Paravastu AK, Hall CK. Simulations and Experiments Delineate Amyloid Fibrilization by Peptides Derived from Glaucoma-Associated Myocilin. The Journal of Physical Chemistry. B. PMID 29724098 DOI: 10.1021/acs.jpcb.8b03000  1
2018 Goldenzweig A, Goldsmith M, Hill SE, Gertman O, Laurino P, Ashani Y, Dym O, Unger T, Albeck S, Prilusky J, Lieberman RL, Aharoni A, Silman I, Sussman JL, Tawfik DS, et al. Automated Structure- and Sequence-Based Design of Proteins for High Bacterial Expression and Stability. Molecular Cell. 70: 380. PMID 29677494 DOI: 10.1016/j.molcel.2018.03.035  1
2018 Huard DJ, Crowley VM, Du Y, Cordova RA, Sun Z, Tomlin MO, Dickey CA, Koren J, Blair L, Fu H, Blagg BSJ, Lieberman RL. Trifunctional high-throughput screen identifies promising scaffold to inhibit Grp94 and treat myocilin-associated glaucoma. Acs Chemical Biology. PMID 29402077 DOI: 10.1021/acschembio.7b01083  1
2017 Stothert AR, Suntharalingam A, Tang X, Crowley VM, Mishra SJ, Webster JM, Nordhues BA, Huard DJE, Passaglia CL, Lieberman RL, Blagg BSJ, Blair LJ, Koren J, Dickey CA. Isoform-selective Hsp90 inhibition rescues model of hereditary open-angle glaucoma. Scientific Reports. 7: 17951. PMID 29263415 DOI: 10.1038/s41598-017-18344-4  1
2017 Hill SE, Nguyen E, Donegan RK, Patterson-Orazem AC, Hazel A, Gumbart JC, Lieberman RL. Structure and Misfolding of the Flexible Tripartite Coiled-Coil Domain of Glaucoma-Associated Myocilin. Structure (London, England : 1993). PMID 29056483 DOI: 10.1016/j.str.2017.09.008  1
2017 Hill SE, Nguyen E, Ukachukwu CU, Freeman DM, Quirk S, Lieberman RL. Metal ion coordination in the E. coli Nudix hydrolase dihydroneopterin triphosphate pyrophosphatase: New clues into catalytic mechanism. Plos One. 12: e0180241. PMID 28742822 DOI: 10.1371/journal.pone.0180241  1
2016 Goldenzweig A, Goldsmith M, Hill SE, Gertman O, Laurino P, Ashani Y, Dym O, Unger T, Albeck S, Prilusky J, Lieberman RL, Aharoni A, Silman I, Sussman JL, Tawfik DS, et al. Automated Structure- and Sequence-Based Design of Proteins for High Bacterial Expression and Stability. Molecular Cell. PMID 27425410 DOI: 10.1016/j.molcel.2016.06.012  1
2016 Crowley VM, Khandelwal A, Mishra S, Stothert AR, Huard DJ, Zhao J, Muth A, Duerfeldt AS, Kizziah JL, Lieberman RL, Dickey CA, Blagg BS. Development of Glucose Regulated Protein 94-Selective Inhibitors based on the BnIm and Radamide Scaffold. Journal of Medicinal Chemistry. PMID 27003516 DOI: 10.1021/acs.jmedchem.6b00085  1
2015 Donegan RK, Lieberman RL. Discovery of Molecular Therapeutics for Glaucoma: Challenges, Successes, and Promising Directions. Journal of Medicinal Chemistry. PMID 26356532 DOI: 10.1021/acs.jmedchem.5b00828  1
2015 Entzminger KC, Johnson JL, Hyun J, Lieberman RL, Maynard JA. Increased Fab thermoresistance via VH-targeted directed evolution. Protein Engineering, Design & Selection : Peds. PMID 26283664 DOI: 10.1093/protein/gzv037  1
2015 Hill SE, Donegan RK, Nguyen E, Desai TM, Lieberman RL. Molecular Details of Olfactomedin Domains Provide Pathway to Structure-Function Studies. Plos One. 10: e0130888. PMID 26121352 DOI: 10.1371/journal.pone.0130888  1
2015 Naing SH, Vukoti KM, Drury JE, Johnson JL, Kalyoncu S, Hill SE, Torres MP, Lieberman RL. Catalytic properties of intramembrane aspartyl protease substrate hydrolysis evaluated using a FRET peptide cleavage assay. Acs Chemical Biology. PMID 26118406 DOI: 10.1021/acschembio.5b00305  1
2015 Johnson JL, Entzminger KC, Hyun J, Kalyoncu S, Heaner DP, Morales IA, Sheppard A, Gumbart JC, Maynard JA, Lieberman RL. Structural and biophysical characterization of an epitope-specific engineered Fab fragment and complexation with membrane proteins: implications for co-crystallization. Acta Crystallographica. Section D, Biological Crystallography. 71: 896-906. PMID 25849400 DOI: 10.1107/S1399004715001856  1
2015 Donegan RK, Hill SE, Freeman DM, Nguyen E, Orwig SD, Turnage KC, Lieberman RL. Structural basis for misfolding in myocilin-associated glaucoma. Human Molecular Genetics. 24: 2111-24. PMID 25524706 DOI: 10.1093/hmg/ddu730  1
2014 Stothert AR, Suntharalingam A, Huard DJ, Fontaine SN, Crowley VM, Mishra S, Blagg BS, Lieberman RL, Dickey CA. Exploiting the interaction between Grp94 and aggregated myocilin to treat glaucoma. Human Molecular Genetics. 23: 6470-80. PMID 25027323 DOI: 10.1093/hmg/ddu367  1
2014 Yu Y, Mena-Barragán T, Higaki K, Johnson JL, Drury JE, Lieberman RL, Nakasone N, Ninomiya H, Tsukimura T, Sakuraba H, Suzuki Y, Nanba E, Mellet CO, García Fernández JM, Ohno K. Molecular basis of 1-deoxygalactonojirimycin arylthiourea binding to human α-galactosidase a: pharmacological chaperoning efficacy on Fabry disease mutants. Acs Chemical Biology. 9: 1460-9. PMID 24783948 DOI: 10.1021/cb500143h  1
2014 Kalyoncu S, Hyun J, Pai JC, Johnson JL, Entzminger K, Jain A, Heaner DP, Morales IA, Truskett TM, Maynard JA, Lieberman RL. Effects of protein engineering and rational mutagenesis on crystal lattice of single chain antibody fragments. Proteins. 82: 1884-95. PMID 24615866 DOI: 10.1002/prot.24542  1
2014 Hill SE, Donegan RK, Lieberman RL. The glaucoma-associated olfactomedin domain of myocilin forms polymorphic fibrils that are constrained by partial unfolding and peptide sequence. Journal of Molecular Biology. 426: 921-35. PMID 24333014 DOI: 10.1016/j.jmb.2013.12.002  1
2014 Orwig SD, Chi PV, Du Y, Hill SE, Cavitt MA, Suntharalingam A, Turnage KC, Dickey CA, France S, Fu H, Lieberman RL. Ligands for glaucoma-associated myocilin discovered by a generic binding assay. Acs Chemical Biology. 9: 517-25. PMID 24279319 DOI: 10.1021/cb4007776  1
2014 Bethel CM, Lieberman RL. Protein structure and function: An interdisciplinary multimedia-based guided-inquiry education module for the high school science classroom Journal of Chemical Education. 91: 52-55. DOI: 10.1021/ed300677t  1
2013 Lieberman RL, Peek ME, Watkins JD. Determination of soluble and membrane protein structures by X-ray crystallography. Methods in Molecular Biology (Clifton, N.J.). 955: 475-93. PMID 23132076 DOI: 10.1007/978-1-62703-176-9_25  1
2012 Donegan RK, Lieberman RL. New direction for glaucoma therapeutics: focus on the olfactomedin domain of myocilin. Future Medicinal Chemistry. 4: 2131-4. PMID 23190098 DOI: 10.4155/fmc.12.132  1
2012 Donegan RK, Hill SE, Turnage KC, Orwig SD, Lieberman RL. The glaucoma-associated olfactomedin domain of myocilin is a novel calcium binding protein. The Journal of Biological Chemistry. 287: 43370-7. PMID 23129764 DOI: 10.1074/jbc.M112.408906  1
2012 Suntharalingam A, Abisambra JF, O'Leary JC, Koren J, Zhang B, Joe MK, Blair LJ, Hill SE, Jinwal UK, Cockman M, Duerfeldt AS, Tomarev S, Blagg BS, Lieberman RL, Dickey CA. Glucose-regulated protein 94 triage of mutant myocilin through endoplasmic reticulum-associated degradation subverts a more efficient autophagic clearance mechanism. The Journal of Biological Chemistry. 287: 40661-9. PMID 23035116 DOI: 10.1074/jbc.M112.384800  1
2012 Orwig SD, Perry CW, Kim LY, Turnage KC, Zhang R, Vollrath D, Schmidt-Krey I, Lieberman RL. Amyloid fibril formation by the glaucoma-associated olfactomedin domain of myocilin. Journal of Molecular Biology. 421: 242-55. PMID 22197377 DOI: 10.1016/j.jmb.2011.12.016  1
2011 Orwig SD, Tan YL, Grimster NP, Yu Z, Powers ET, Kelly JW, Lieberman RL. Binding of 3,4,5,6-tetrahydroxyazepanes to the acid-β-glucosidase active site: implications for pharmacological chaperone design for Gaucher disease. Biochemistry. 50: 10647-57. PMID 22047104 DOI: 10.1021/bi201619z  1
2011 Lieberman RL, Culver JA, Entzminger KC, Pai JC, Maynard JA. Crystallization chaperone strategies for membrane proteins. Methods (San Diego, Calif.). 55: 293-302. PMID 21854852 DOI: 10.1016/j.ymeth.2011.08.004  1
2011 Burns JN, Turnage KC, Walker CA, Lieberman RL. The stability of myocilin olfactomedin domain variants provides new insight into glaucoma as a protein misfolding disorder. Biochemistry. 50: 5824-33. PMID 21612213 DOI: 10.1021/bi200231x  1
2011 Orwig SD, Lieberman RL. Biophysical characterization of the olfactomedin domain of myocilin, an extracellular matrix protein implicated in inherited forms of glaucoma. Plos One. 6: e16347. PMID 21283635 DOI: 10.1371/journal.pone.0016347  1
2011 Pai JC, Culver JA, Drury JE, Motani RS, Lieberman RL, Maynard JA. Conversion of scFv peptide-binding specificity for crystal chaperone development. Protein Engineering, Design & Selection : Peds. 24: 419-28. PMID 21217145 DOI: 10.1093/protein/gzq120  1
2010 Burns JN, Orwig SD, Harris JL, Watkins JD, Vollrath D, Lieberman RL. Rescue of glaucoma-causing mutant myocilin thermal stability by chemical chaperones. Acs Chemical Biology. 5: 477-87. PMID 20334347 DOI: 10.1021/cb900282e  1
2009 Landon MR, Lieberman RL, Hoang QQ, Ju S, Caaveiro JM, Orwig SD, Kozakov D, Brenke R, Chuang GY, Beglov D, Vajda S, Petsko GA, Ringe D. Detection of ligand binding hot spots on protein surfaces via fragment-based methods: application to DJ-1 and glucocerebrosidase. Journal of Computer-Aided Molecular Design. 23: 491-500. PMID 19521672 DOI: 10.1007/s10822-009-9283-2  1
2009 Lieberman RL, D'aquino JA, Ringe D, Petsko GA. Effects of pH and iminosugar pharmacological chaperones on lysosomal glycosidase structure and stability. Biochemistry. 48: 4816-27. PMID 19374450 DOI: 10.1021/bi9002265  1
2007 Lieberman RL, Wustman BA, Huertas P, Powe AC, Pine CW, Khanna R, Schlossmacher MG, Ringe D, Petsko GA. Structure of acid beta-glucosidase with pharmacological chaperone provides insight into Gaucher disease. Nature Chemical Biology. 3: 101-7. PMID 17187079 DOI: 10.1038/nchembio850  1
2006 Lieberman RL, Kondapalli KC, Shrestha DB, Hakemian AS, Smith SM, Telser J, Kuzelka J, Gupta R, Borovik AS, Lippard SJ, Hoffman BM, Rosenzweig AC, Stemmler TL. Characterization of the particulate methane monooxygenase metal centers in multiple redox states by X-ray absorption spectroscopy. Inorganic Chemistry. 45: 8372-81. PMID 16999437 DOI: 10.1021/ic060739v  1
2006 Lieberman RL, Rosenzweig AC. Biophysical and structural characterization of particulate methane monooxygenase Acs National Meeting Book of Abstracts. 231.  1
2005 Lieberman RL, Rosenzweig AC. The quest for the particulate methane monooxygenase active site. Dalton Transactions (Cambridge, England : 2003). 3390-6. PMID 16234916 DOI: 10.1039/b506651d  1
2005 Sommerhalter M, Lieberman RL, Rosenzweig AC. X-ray crystallography and biological metal centers: is seeing believing? Inorganic Chemistry. 44: 770-8. PMID 15859245 DOI: 10.1021/ic0485256  1
2005 Lieberman RL, Rosenzweig AC. Crystal structure of a membrane-bound metalloenzyme that catalyses the biological oxidation of methane. Nature. 434: 177-82. PMID 15674245 DOI: 10.1038/nature03311  1
2004 Lieberman RL, Rosenzweig AC. Biological methane oxidation: regulation, biochemistry, and active site structure of particulate methane monooxygenase. Critical Reviews in Biochemistry and Molecular Biology. 39: 147-64. PMID 15596549 DOI: 10.1080/10409230490475507  1
2004 Lieberman RL, Rosenzweig AC. Metal Ion Homeostasis Comprehensive Coordination Chemistry Ii. 8: 195-211. DOI: 10.1016/B0-08-043748-6/08136-6  1
2004 Lieberman RL, Rosenzweig AC. Metal Ion Homeostasis Comprehensive Coordination Chemistry Ii. 8: 195-211. DOI: 10.1016/B0-08-043748-6/08136-6  1
2004 Lieberman RL, Rosenzweig AC. Crystallographic trapping of a precatalytic enzyme complex provides new insight into dioxygen activation at a mononuclear copper center Chemtracts. 17: 562-568.  1
2003 Lieberman RL, Shrestha DB, Doan PE, Hoffman BM, Stemmler TL, Rosenzweig AC. Purified particulate methane monooxygenase from Methylococcus capsulatus (Bath) is a dimer with both mononuclear copper and a copper-containing cluster. Proceedings of the National Academy of Sciences of the United States of America. 100: 3820-5. PMID 12634423 DOI: 10.1073/pnas.0536703100  1
2001 Lieberman RL, Arciero DM, Hooper AB, Rosenzweig AC. Crystal structure of a novel red copper protein from Nitrosomonas europaea. Biochemistry. 40: 5674-81. PMID 11341832 DOI: 10.1021/bi0102611  1
2000 Lieberman RL, Bino A, Mirsky N, Summers DA, Thompson RC. Synthesis, structure and magnetic properties of a chromium(III)-nicotinamide complex [Cr3O(O2CCH3)6(na)3]+ (na = nicotinamide) Inorganica Chimica Acta. 297: 1-5. DOI: 10.1016/S0020-1693(99)00251-0  1
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