Kenneth H. Downing - Publications

Affiliations: 
Comparative Biochemistry University of California, Berkeley, Berkeley, CA 
Area:
Cell Biology, Neuroscience Biology, Biochemistry

150 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any innacuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2018 Kellogg EH, Hejab NMA, Poepsel S, Downing KH, DiMaio F, Nogales E. Near-atomic model of microtubule-tau interactions. Science (New York, N.Y.). PMID 29748322 DOI: 10.1126/science.aat1780  1
2017 Killilea AN, Csencsits R, Le E, Patel AM, Kenny SJ, Xu K, Downing KH. Cytoskeletal Organization in Microtentacles. Experimental Cell Research. PMID 28551375 DOI: 10.1016/j.yexcr.2017.05.024  0.6
2017 Kellogg EH, Hejab NM, Howes S, Northcote P, Miller JH, Fernando Díaz J, Downing KH, Nogales E. Insights into the distinct mechanisms of action of taxane and non-taxane microtubule stabilizers from cryo-EM structures. Journal of Molecular Biology. PMID 28104363 DOI: 10.1016/j.jmb.2017.01.001  1
2015 Marabini R, Carragher B, Chen S, Chen J, Cheng A, Downing KH, Frank J, Grassucci RA, Bernard Heymann J, Jiang W, Jonic S, Liao HY, Ludtke SJ, Patwari S, Piotrowski AL, et al. CTF Challenge: Result summary. Journal of Structural Biology. 190: 348-59. PMID 25913484 DOI: 10.1016/j.jsb.2015.04.003  0.44
2015 Luef B, Frischkorn KR, Wrighton KC, Holman HY, Birarda G, Thomas BC, Singh A, Williams KH, Siegerist CE, Tringe SG, Downing KH, Comolli LR, Banfield JF. Diverse uncultivated ultra-small bacterial cells in groundwater. Nature Communications. 6: 6372. PMID 25721682 DOI: 10.1038/ncomms7372  1
2014 Sarkar P, Bosneaga E, Yap EG, Das J, Tsai WT, Cabal A, Neuhaus E, Maji D, Kumar S, Joo M, Yakovlev S, Csencsits R, Yu Z, Bajaj C, Downing KH, et al. Electron tomography of cryo-immobilized plant tissue: a novel approach to studying 3D macromolecular architecture of mature plant cell walls in situ. Plos One. 9: e106928. PMID 25207917 DOI: 10.1371/journal.pone.0106928  0.44
2014 Chen XC, Wong DT, Yakovlev S, Beers KM, Downing KH, Balsara NP. Effect of morphology of nanoscale hydrated channels on proton conductivity in block copolymer electrolyte membranes. Nano Letters. 14: 4058-64. PMID 24854241 DOI: 10.1021/nl501537p  1
2014 Beers KM, Yakovlev S, Jackson A, Wang X, Hexemer A, Downing KH, Balsara NP. Absence of Schroeder's paradox in a nanostructured block copolymer electrolyte membrane. The Journal of Physical Chemistry. B. 118: 6785-91. PMID 24842682 DOI: 10.1021/jp501374r  1
2013 Yakovlev S, Balsara NP, Downing KH. Insights on the study of nafion nanoscale morphology by transmission electron microscopy. Membranes. 3: 424-39. PMID 24957067 DOI: 10.3390/membranes3040424  1
2013 Glaeser RM, Sassolini S, Cambie R, Jin J, Cabrini S, Schmid AK, Danev R, Buijsse B, Csencsits R, Downing KH, Larson DM, Typke D, Han BG. Minimizing electrostatic charging of an aperture used to produce in-focus phase contrast in the TEM. Ultramicroscopy. 135: 6-15. PMID 23872037 DOI: 10.1016/j.ultramic.2013.05.023  1
2013 Ounjai P, Kim KD, Liu H, Dong M, Tauscher AN, Witkowska HE, Downing KH. Architectural insights into a ciliary partition. Current Biology : Cb. 23: 339-44. PMID 23375896 DOI: 10.1016/j.cub.2013.01.029  1
2013 Yakovlev S, Downing KH. Visualization of clusters in polymer electrolyte membranes by electron microscopy. Physical Chemistry Chemical Physics : Pccp. 15: 1052-64. PMID 23165242 DOI: 10.1039/c2cp42969a  1
2013 Downing KH. Future developments in instrumentation for electron crystallography. Methods in Molecular Biology (Clifton, N.J.). 955: 353-79. PMID 23132071 DOI: 10.1007/978-1-62703-176-9_20  1
2013 Luef B, Fakra SC, Csencsits R, Wrighton KC, Williams KH, Wilkins MJ, Downing KH, Long PE, Comolli LR, Banfield JF. Iron-reducing bacteria accumulate ferric oxyhydroxide nanoparticle aggregates that may support planktonic growth. The Isme Journal. 7: 338-50. PMID 23038172 DOI: 10.1038/ismej.2012.103  1
2012 Watkins BY, Joshi SA, Ball DA, Leggett H, Park S, Kim J, Austin CD, Paler-Martinez A, Xu M, Downing KH, Brown EJ. Mycobacterium marinum SecA2 promotes stable granulomas and induces tumor necrosis factor alpha in vivo. Infection and Immunity. 80: 3512-20. PMID 22851747 DOI: 10.1128/IAI.00686-12  1
2012 Ounjai P, Kim KD, Lishko PV, Downing KH. Three-dimensional structure of the bovine sperm connecting piece revealed by electron cryotomography. Biology of Reproduction. 87: 73. PMID 22767409 DOI: 10.1095/biolreprod.112.101980  1
2012 Dong H, Shu JY, Dube N, Ma Y, Tirrell MV, Downing KH, Xu T. 3-Helix micelles stabilized by polymer springs. Journal of the American Chemical Society. 134: 11807-14. PMID 22731391 DOI: 10.1021/ja3048128  1
2012 Henderson R, Sali A, Baker ML, Carragher B, Devkota B, Downing KH, Egelman EH, Feng Z, Frank J, Grigorieff N, Jiang W, Ludtke SJ, Medalia O, Penczek PA, Rosenthal PB, et al. Outcome of the first electron microscopy validation task force meeting. Structure (London, England : 1993). 20: 205-14. PMID 22325770 DOI: 10.1016/j.str.2011.12.014  1
2012 Comolli LR, Duarte R, Baum D, Luef B, Downing KH, Larson DM, Csencsits R, Banfield JF. A portable cryo-plunger for on-site intact cryogenic microscopy sample preparation in natural environments. Microscopy Research and Technique. 75: 829-36. PMID 22213355 DOI: 10.1002/jemt.22001  1
2012 Yakovlev S, Balsara NP, Downing KH. Limits of spatial and compositional resolution of electron energy loss spectroscopy of soft materials Ultramicroscopy. 116: 39-46. DOI: 10.1016/j.ultramic.2012.03.003  1
2011 Yakovlev S, Wang X, Ercius P, Balsara NP, Downing KH. Direct imaging of nanoscale acidic clusters in a polymer electrolyte membrane. Journal of the American Chemical Society. 133: 20700-3. PMID 22107080 DOI: 10.1021/ja209240d  1
2011 Yakovlev S, Downing KH. Freezing in sealed capillaries for preparation of frozen hydrated sections Journal of Microscopy. 244: 235-247. PMID 22077543 DOI: 10.1111/j.1365-2818.2011.03530.x  1
2011 Yakovlev S, Downing KH. Crystalline ice as a cryoprotectant: Theoretical calculation of cooling speed in capillary tubes Journal of Microscopy. 243: 8-14. PMID 21534954 DOI: 10.1111/j.1365-2818.2011.03498.x  1
2011 Larson DM, Downing KH, Glaeser RM. The surface of evaporated carbon films is an insulating, high-bandgap material. Journal of Structural Biology. 174: 420-3. PMID 21338687 DOI: 10.1016/j.jsb.2011.02.005  1
2011 Wang H, Downing KH. Specimen preparation for electron diffraction of thin crystals. Micron (Oxford, England : 1993). 42: 132-40. PMID 20561794 DOI: 10.1016/j.micron.2010.05.003  1
2010 Downing KH. Commentary on "Structure of a conserved retroviral RNA packaging element by NMR spectroscopy and cryo-electron tomography" by Y. Miyazaki et al. Journal of Molecular Biology. 404: 749-50. PMID 20965201 DOI: 10.1016/j.jmb.2010.10.021  1
2010 Downing KH, Nogales E. Cryoelectron microscopy applications in the study of tubulin structure, microtubule architecture, dynamics and assemblies, and interaction of microtubules with motors. Methods in Enzymology. 483: 121-42. PMID 20888472 DOI: 10.1016/S0076-6879(10)83006-X  1
2010 Amat F, Comolli LR, Nomellini JF, Moussavi F, Downing KH, Smit J, Horowitz M. Analysis of the intact surface layer of Caulobacter crescentus by cryo-electron tomography. Journal of Bacteriology. 192: 5855-65. PMID 20833802 DOI: 10.1128/JB.00747-10  1
2010 Sui H, Downing KH. Structural basis of interprotofilament interaction and lateral deformation of microtubules. Structure (London, England : 1993). 18: 1022-31. PMID 20696402 DOI: 10.1016/j.str.2010.05.010  1
2010 Yeh YC, Comolli LR, Downing KH, Shapiro L, McAdams HH. The caulobacter Tol-Pal complex is essential for outer membrane integrity and the positioning of a polar localization factor. Journal of Bacteriology. 192: 4847-58. PMID 20693330 DOI: 10.1128/JB.00607-10  0.36
2010 Amat F, Comolli LR, Moussavi F, Smit J, Downing KH, Horowitz M. Subtomogram alignment by adaptive Fourier coefficient thresholding. Journal of Structural Biology. 171: 332-44. PMID 20621702 DOI: 10.1016/j.jsb.2010.05.013  1
2010 Byrne ME, Ball DA, Guerquin-Kern JL, Rouiller I, Wu TD, Downing KH, Vali H, Komeili A. Desulfovibrio magneticus RS-1 contains an iron- and phosphorus-rich organelle distinct from its bullet-shaped magnetosomes. Proceedings of the National Academy of Sciences of the United States of America. 107: 12263-8. PMID 20566879 DOI: 10.1073/pnas.1001290107  1
2010 Goley ED, Comolli LR, Fero KE, Downing KH, Shapiro L. DipM links peptidoglycan remodelling to outer membrane organization in Caulobacter. Molecular Microbiology. 77: 56-73. PMID 20497504 DOI: 10.1111/j.1365-2958.2010.07222.x  1
2010 Sindelar CV, Downing KH. An atomic-level mechanism for activation of the kinesin molecular motors. Proceedings of the National Academy of Sciences of the United States of America. 107: 4111-6. PMID 20160108 DOI: 10.1073/pnas.0911208107  1
2010 Bowman GR, Comolli LR, Gaietta GM, Fero M, Hong SH, Jones Y, Lee JH, Downing KH, Ellisman MH, McAdams HH, Shapiro L. Caulobacter PopZ forms a polar subdomain dictating sequential changes in pole composition and function. Molecular Microbiology. 76: 173-89. PMID 20149103 DOI: 10.1111/j.1365-2958.2010.07088.x  1
2010 Yeh YC, Comolli LR, Downing KH, Shapiro L, McAdams HH. The Caulobacter Tol-Pal complex is essential for outer membrane integrity and the positioning of a polar localization factor Journal of Bacteriology. 192: 4847-4858. DOI: 10.1128/JB.00607-10  1
2010 Wang X, Yakovlev S, Beers KM, Park MJ, Mullin SA, Downing KH, Balsara NP. On the origin of slow changes in ionic conductivity of model block copolymer electrolyte membranes in contact with humid air Macromolecules. 43: 5306-5314. DOI: 10.1021/ma100719m  1
2009 Nettles JH, Downing KH. The tubulin binding mode of microtubule stabilizing agents studied by electron crystallography. Topics in Current Chemistry. 286: 209-57. PMID 23563614 DOI: 10.1007/128_2008_24  1
2009 Han BG, Dong M, Liu H, Camp L, Geller J, Singer M, Hazen TC, Choi M, Witkowska HE, Ball DA, Typke D, Downing KH, Shatsky M, Brenner SE, Chandonia JM, et al. Survey of large protein complexes in D. vulgaris reveals great structural diversity. Proceedings of the National Academy of Sciences of the United States of America. 106: 16580-5. PMID 19805340 DOI: 10.1073/pnas.0813068106  1
2009 Holman HY, Wozei E, Lin Z, Comolli LR, Ball DA, Borglin S, Fields MW, Hazen TC, Downing KH. Real-time molecular monitoring of chemical environment in obligate anaerobes during oxygen adaptive response. Proceedings of the National Academy of Sciences of the United States of America. 106: 12599-604. PMID 19541631 DOI: 10.1073/pnas.0902070106  1
2009 Gomez ED, Panday A, Feng EH, Chen V, Stone GM, Minor AM, Kisielowski C, Downing KH, Borodin O, Smith GD, Balsara NP. Effect of ion distribution on conductivity of block copolymer electrolytes. Nano Letters. 9: 1212-6. PMID 19193125 DOI: 10.1021/nl900091n  1
2009 Comolli LR, Baker BJ, Downing KH, Siegerist CE, Banfield JF. Three-dimensional analysis of the structure and ecology of a novel, ultra-small archaeon. The Isme Journal. 3: 159-67. PMID 18946497 DOI: 10.1038/ismej.2008.99  1
2008 Bowman GR, Comolli LR, Zhu J, Eckart M, Koenig M, Downing KH, Moerner WE, Earnest T, Shapiro L. A polymeric protein anchors the chromosomal origin/ParB complex at a bacterial cell pole. Cell. 134: 945-55. PMID 18805088 DOI: 10.1016/j.cell.2008.07.015  1
2008 Dietrich KA, Sindelar CV, Brewer PD, Downing KH, Cremo CR, Rice SE. The kinesin-1 motor protein is regulated by a direct interaction of its head and tail. Proceedings of the National Academy of Sciences of the United States of America. 105: 8938-43. PMID 18579780 DOI: 10.1073/pnas.0803575105  1
2008 Downing KH, Glaeser RM. Restoration of weak phase-contrast images recorded with a high degree of defocus: the "twin image" problem associated with CTF correction. Ultramicroscopy. 108: 921-8. PMID 18508199 DOI: 10.1016/j.ultramic.2008.03.004  1
2008 Downing KH, Mooney PE. A charge coupled device camera with electron decelerator for intermediate voltage electron microscopy. The Review of Scientific Instruments. 79: 043702. PMID 18447528 DOI: 10.1063/1.2902853  1
2008 Comolli LR, Spakowitz AJ, Siegerist CE, Jardine PJ, Grimes S, Anderson DL, Bustamante C, Downing KH. Three-dimensional architecture of the bacteriophage phi29 packaged genome and elucidation of its packaging process. Virology. 371: 267-77. PMID 18001811 DOI: 10.1016/j.virol.2007.07.035  1
2008 Amat F, Moussavi F, Comolli LR, Elidan G, Downing KH, Horowitz M. Markov random field based automatic image alignment for electron tomography. Journal of Structural Biology. 161: 260-75. PMID 17855124 DOI: 10.1016/j.jsb.2007.07.007  1
2008 Radenovic A, Trepagnier E, Csencsits R, Downing KH, Liphardt J. Fabrication of 10 nm diameter hydrocarbon nanopores Applied Physics Letters. 93. DOI: 10.1063/1.3012376  1
2008 Gomez ED, Ruegg ML, Minor AM, Kisielowski C, Downing KH, Glaeser RM, Balsara NP. Interfacial concentration profiles of rubbery polyolefin lamellae determined by quantitative electron microscopy Macromolecules. 41: 156-162. DOI: 10.1021/ma071498t  1
2008 Typke D, Glaeser RM, Downing KH, Tiemeijer PC, Cambie R, Jin J. Aspects of using a Boersch type phase shifting device for contrast enhancement in macromolecular electron microscopy Microscopy and Microanalysis. 14: 74-75. DOI: 10.1017/S1431927608088946  1
2008 Sui H, Downing KH. Structural study of multiple microtubule types by cryo-electron microscopy Microscopy and Microanalysis. 14: 1478-1479. DOI: 10.1017/S1431927608087771  1
2007 Downing KH, Sui H, Auer M. Electron tomography: a 3D view of the subcellular world. Analytical Chemistry. 79: 7949-57. PMID 18044021 DOI: 10.1021/ac071982u  1
2007 Park MJ, Downing KH, Jackson A, Gomez ED, Minor AM, Cookson D, Weber AZ, Balsara NP. Increased water retention in polymer electrolyte membranes at elevated temperatures assisted by capillary condensation. Nano Letters. 7: 3547-52. PMID 17960948 DOI: 10.1021/nl072617l  1
2007 Wille H, Govaerts C, Borovinskiy A, Latawiec D, Downing KH, Cohen FE, Prusiner SB. Electron crystallography of the scrapie prion protein complexed with heavy metals. Archives of Biochemistry and Biophysics. 467: 239-48. PMID 17935686 DOI: 10.1016/j.abb.2007.08.010  1
2007 Killilea AN, Downing KH, Killilea DW. Zinc deficiency reduces paclitaxel efficacy in LNCaP prostate cancer cells. Cancer Letters. 258: 70-9. PMID 17905512 DOI: 10.1016/j.canlet.2007.08.010  1
2007 Sindelar CV, Downing KH. The beginning of kinesin's force-generating cycle visualized at 9-A resolution. The Journal of Cell Biology. 177: 377-85. PMID 17470637 DOI: 10.1083/jcb.200612090  1
2007 Downing KH, Sui H. Structural insights into microtubule doublet interactions in axonemes. Current Opinion in Structural Biology. 17: 253-9. PMID 17387011 DOI: 10.1016/j.sbi.2007.03.013  1
2007 Typke D, Gilpin CJ, Downing KH, Glaeser RM. Stroboscopic image capture: reducing the dose per frame by a factor of 30 does not prevent beam-induced specimen movement in paraffin. Ultramicroscopy. 107: 106-15. PMID 16905258 DOI: 10.1016/j.ultramic.2006.06.005  1
2007 Cambie R, Downing KH, Typke D, Glaeser RM, Jin J. Design of a microfabricated, two-electrode phase-contrast element suitable for electron microscopy Ultramicroscopy. 107: 329-339. DOI: 10.1016/j.ultramic.2006.09.001  1
2006 Comolli LR, Kundmann M, Downing KH. Characterization of intact subcellular bodies in whole bacteria by cryo-electron tomography and spectroscopic imaging. Journal of Microscopy. 223: 40-52. PMID 16872430 DOI: 10.1111/j.1365-2818.2006.01597.x  1
2006 Sui H, Downing KH. Molecular architecture of axonemal microtubule doublets revealed by cryo-electron tomography. Nature. 442: 475-8. PMID 16738547 DOI: 10.1038/nature04816  1
2006 Rosenberg OS, Deindl S, Comolli LR, Hoelz A, Downing KH, Nairn AC, Kuriyan J. Oligomerization states of the association domain and the holoenyzme of Ca2+/CaM kinase II. The Febs Journal. 273: 682-94. PMID 16441656 DOI: 10.1111/j.1742-4658.2005.05088.x  1
2005 Judd EM, Comolli LR, Chen JC, Downing KH, Moerner WE, McAdams HH. Distinct constrictive processes, separated in time and space, divide caulobacter inner and outer membranes. Journal of Bacteriology. 187: 6874-82. PMID 16199556 DOI: 10.1128/JB.187.20.6874-6882.2005  1
2005 Comolli LR, Downing KH. Dose tolerance at helium and nitrogen temperatures for whole cell electron tomography. Journal of Structural Biology. 152: 149-56. PMID 16198601 DOI: 10.1016/j.jsb.2005.08.004  1
2005 Typke D, Nordmeyer RA, Jones A, Lee J, Avila-Sakar A, Downing KH, Glaeser RM. High-throughput film-densitometry: an efficient approach to generate large data sets. Journal of Structural Biology. 149: 17-29. PMID 15629654 DOI: 10.1016/j.jsb.2004.09.003  1
2005 Kim TK, Wells J, Kirkegaard C, Li Z, Hoffmann SV, Gayone JE, Fernandez-Torrente I, Häberle P, Pascual JI, Moore KT, Schwartz AJ, He H, Spence JCH, Downing KH, Lazar S, et al. Evidence against a charge density wave on Bi(111) Physical Review B - Condensed Matter and Materials Physics. 72. DOI: 10.1103/PhysRevB.72.085440  1
2004 Glaeser RM, Downing KH. Specimen charging on thin films with one conducting layer: discussion of physical principles. Microscopy and Microanalysis : the Official Journal of Microscopy Society of America, Microbeam Analysis Society, Microscopical Society of Canada. 10: 790-6. PMID 19780321 DOI: 10.1017/S1431927604040668  1
2004 Downing KH, McCartney MR, Glaeser RM. Experimental characterization and mitigation of specimen charging on thin films with one conducting layer. Microscopy and Microanalysis : the Official Journal of Microscopy Society of America, Microbeam Analysis Society, Microscopical Society of Canada. 10: 783-9. PMID 19780320 DOI: 10.1017/S143192760404067X  1
2004 Typke D, Downing KH, Glaeser RM. Electron microscopy of biological macromolecules: bridging the gap between what physics allows and what we currently can get. Microscopy and Microanalysis : the Official Journal of Microscopy Society of America, Microbeam Analysis Society, Microscopical Society of Canada. 10: 21-7. PMID 15306063 DOI: 10.1017/S1431927604040164  1
2004 Nettles JH, Li H, Cornett B, Krahn JM, Snyder JP, Downing KH. The binding mode of epothilone A on alpha,beta-tubulin by electron crystallography. Science (New York, N.Y.). 305: 866-9. PMID 15297674 DOI: 10.1126/science.1099190  1
2004 Paluh JL, Killilea AN, Detrich HW, Downing KH. Meiosis-specific failure of cell cycle progression in fission yeast by mutation of a conserved beta-tubulin residue. Molecular Biology of the Cell. 15: 1160-71. PMID 14657251 DOI: 10.1091/mbc.E03-06-0389  1
2004 Downing KH, Mooney PE. CCD camera with electron decelerator for intermediate voltage electron microscopy Microscopy and Microanalysis. 10: 1378-1379. DOI: 10.1017/S1431927604882977  1
2004 Downing KH, Sui H, Comolli LR, Holman HY. Electron tomographic studies of bacterial structure and function Microscopy and Microanalysis. 10: 1184-1185. DOI: 10.1017/S1431927604882953  1
2004 Downing KH, Li H, Nettles JH, Snyder JP. Studies of ligand binding to tubulin by electron crystallography Microscopy and Microanalysis. 10: 1500-1501. DOI: 10.1017/S1431927604882941  1
2003 Spence JCH, Weierstall U, Fricke TT, Glaeser RM, Downing KH. Three-dimensional diffractive imaging for crystalline monolayers with one-dimensional compact support Journal of Structural Biology. 144: 209-218. PMID 14643223 DOI: 10.1016/j.jsb.2003.09.019  1
2002 Li H, DeRosier DJ, Nicholson WV, Nogales E, Downing KH. Microtubule structure at 8 A resolution. Structure (London, England : 1993). 10: 1317-28. PMID 12377118 DOI: 10.1016/S0969-2126(02)00827-4  1
2002 Zhong S, Dadarlat VM, Glaeser RM, Head-Gordon T, Downing KH. Modeling chemical bonding effects for protein electron crystallography: the transferable fragmental electrostatic potential (TFESP) method. Acta Crystallographica. Section a, Foundations of Crystallography. 58: 162-70. PMID 11832586 DOI: 10.1107/S0108767301020256  1
2001 Downing KH, Li H. Accurate Recording and Measurement of Electron Diffraction Data in Structural and Difference Fourier Studies of Proteins. Microscopy and Microanalysis : the Official Journal of Microscopy Society of America, Microbeam Analysis Society, Microscopical Society of Canada. 7: 407-417. PMID 12597803 DOI: 10.1017/S1431927601010406  1
2001 Avila-Sakar AJ, Misaghi S, Wilson-Kubalek EM, Downing KH, Zgurskaya H, Nikaido H, Nogales E. Lipid-layer crystallization and preliminary three-dimensional structural analysis of AcrA, the periplasmic component of a bacterial multidrug efflux pump Journal of Structural Biology. 136: 81-88. PMID 11858709 DOI: 10.1006/jsbi.2001.4418  1
2001 Hud NV, Downing KH. Cryoelectron microscopy of lambda phage DNA condensates in vitreous ice: the fine structure of DNA toroids. Proceedings of the National Academy of Sciences of the United States of America. 98: 14925-30. PMID 11734630 DOI: 10.1073/pnas.261560398  1
2001 Facciotti MT, Rouhani S, Burkard FT, Betancourt FM, Downing KH, Rose RB, McDermott G, Glaeser RM. Structure of an early intermediate in the M-state phase of the bacteriorhodopsin photocycle. Biophysical Journal. 81: 3442-55. PMID 11721006 DOI: 10.1016/S0006-3495(01)75976-0  1
2001 Löwe J, Li H, Downing KH, Nogales E. Refined structure of alpha beta-tubulin at 3.5 A resolution. Journal of Molecular Biology. 313: 1045-57. PMID 11700061 DOI: 10.1006/jmbi.2001.5077  1
2001 Snyder JP, Nettles JH, Cornett B, Downing KH, Nogales E. The binding conformation of Taxol in beta-tubulin: a model based on electron crystallographic density. Proceedings of the National Academy of Sciences of the United States of America. 98: 5312-6. PMID 11309480 DOI: 10.1073/pnas.051309398  1
2001 Traub-Cseko YM, Ramalho-Ortigão JM, Dantas AP, De Castro SL, Barbosa HS, Downing KH. Dinitroaniline herbicides against protozoan parasites: The case of Trypanosoma cruzi Trends in Parasitology. 17: 136-141. PMID 11286798 DOI: 10.1016/S1471-4922(00)01834-1  1
2000 Downing KH. Structural basis for the interaction of tubulin with proteins and drugs that affect microtubule dynamics Annual Review of Cell and Developmental Biology. 16: 89-111. PMID 11031231 DOI: 10.1146/annurev.cellbio.16.1.89  1
2000 Detrich HW, Parker SK, Williams RC, Nogales E, Downing KH. Cold adaptation of microtubule assembly and dynamics. Structural interpretation of primary sequence changes present in the alpha- and beta-tubulins of Antarctic fishes. The Journal of Biological Chemistry. 275: 37038-47. PMID 10956651 DOI: 10.1074/jbc.M005699200  1
2000 Richards KL, Anders KR, Nogales E, Schwartz K, Downing KH, Botstein D. Structure-function relationships in yeast tubulins. Molecular Biology of the Cell. 11: 1887-903. PMID 10793159  1
2000 Giannakakou P, Gussio R, Nogales E, Downing KH, Zaharevitz D, Bollbuck B, Poy G, Sackett D, Nicolaou KC, Fojo T. A common pharmacophore for epothilone and taxanes: molecular basis for drug resistance conferred by tubulin mutations in human cancer cells. Proceedings of the National Academy of Sciences of the United States of America. 97: 2904-9. PMID 10688884 DOI: 10.1073/pnas.040546297  1
2000 Downing KH. Structural basis for the action of drugs that affect microtubule dynamics Expert Opinion On Therapeutic Targets. 4: 219-237. DOI: 10.1517/14728222.4.2.219  1
2000 Shen MR, Downing KH, Balhorn R, Hud NV. Nucleation of DNA condensation by static loops: Formation of DNA toroids with reduced dimensions Journal of the American Chemical Society. 122: 4833-4834. DOI: 10.1021/ja000200a  1
1999 Downing KH, Nogales E. Crystallographic structure of tubulin: implications for dynamics and drug binding. Cell Structure and Function. 24: 269-75. PMID 15216882 DOI: 10.1247/csf.24.269  1
1999 Chang S, Head-Gordon T, Glaeser RM, Downing KH. Chemical bonding effects in the determination of protein structures by electron crystallography. Acta Crystallographica Section a: Foundations of Crystallography. 55: Pt 2 Pt 2/-. PMID 10927261  1
1999 Han Y, Sablin EP, Nogales E, Fletterick RJ, Downing KH. Visualizing a new binding site of ncd-motor domain on tubulin. Journal of Structural Biology. 128: 26-33. PMID 10600555 DOI: 10.1006/jsbi.1999.4162  1
1999 Nicholson WV, Lee M, Downing KH, Nogales E. Cryo-electron microscopy of GDP-tubulin rings. Cell Biochemistry and Biophysics. 31: 175-83. PMID 10593258 DOI: 10.1007/BF02738171  1
1999 Nogales E, Whittaker M, Milligan RA, Downing KH. High-resolution model of the microtubule. Cell. 96: 79-88. PMID 9989499 DOI: 10.1016/S0092-8674(00)80961-7  1
1999 Downing KH, Hendrickson FM. Performance of a 2k CCD camera designed for electron crystallography at 400 kV Ultramicroscopy. 75: 215-233. PMID 9919710 DOI: 10.1016/S0304-3991(98)00065-5  1
1999 Feierbach B, Nogales E, Downing KH, Stearns T. Alf1p, a CLIP-170 domain-containing protein, is functionally and physically associated with alpha-tubulin. The Journal of Cell Biology. 144: 113-24. PMID 9885248 DOI: 10.1083/jcb.144.1.113  1
1999 Weierstall U, Spence JCH, Stevens M, Downing KH. Point-projection electron imaging of tobacco mosaic virus at 40 eV electron energy Micron. 30: 335-338. DOI: 10.1016/S0968-4328(99)00022-0  1
1998 Downing KH, Nogales E. Tubulin structure: insights into microtubule properties and functions. Current Opinion in Structural Biology. 8: 785-91. PMID 9914260 DOI: 10.1016/S0959-440X(98)80099-7  1
1998 Downing KH, Nogales E. New insights into microtubule structure and function from the atomic model of tubulin. European Biophysics Journal : Ebj. 27: 431-6. PMID 9760724 DOI: 10.1007/s002490050153  1
1998 Nogales E, Downing KH, Amos LA, Löwe J. Tubulin and FtsZ form a distinct family of GTPases. Nature Structural Biology. 5: 451-8. PMID 9628483 DOI: 10.1038/nsb0698-451  1
1998 Fan GY, Datte P, Beuville E, Beche JF, Millaud J, Downing KH, Burkard FT, Ellisman MH, Xuong NH. ASIC-based event-driven 2D digital electron counter for TEM imaging. Ultramicroscopy. 70: 107-13. PMID 9499588 DOI: 10.1016/S0304-3991(97)00109-5  1
1998 Downing KH, Nogales E. Tubulin and microtubule structure. Current Opinion in Cell Biology. 10: 16-22. PMID 9484591 DOI: 10.1016/S0955-0674(98)80082-3  1
1998 Nogales E, Wolf SG, Downing KH. Structure of the alpha beta tubulin dimer by electron crystallography. Nature. 391: 199-203. PMID 9428769 DOI: 10.1038/34465  1
1997 Nogales E, Wolf SG, Downing KH. Visualizing the secondary structure of tubulin: three-dimensional map at 4 A. Journal of Structural Biology. 118: 119-27. PMID 9126638 DOI: 10.1006/jsbi.1997.3841  1
1996 Wolf SG, Nogales E, Kikkawa M, Gratzinger D, Hirokawa N, Downing KH. Interpreting a medium-resolution model of tubulin: comparison of zinc-sheet and microtubule structure. Journal of Molecular Biology. 262: 485-501. PMID 8893858 DOI: 10.1006/jmbi.1996.0530  1
1996 Grigorieff N, Ceska TA, Downing KH, Baldwin JM, Henderson R. Electron-crystallographic refinement of the structure of bacteriorhodopsin. Journal of Molecular Biology. 259: 393-421. PMID 8676377 DOI: 10.1006/jmbi.1996.0328  1
1996 Cady SL, Wenk HR, Downing KH. HRTEM of microcrystalline opal in chert and porcelanite from the Monterey Formation, California American Mineralogist. 81: 1380-1395.  1
1995 McEwen BF, Downing KH, Glaeser RM. The relevance of dose-fractionation in tomography of radiation-sensitive specimens Ultramicroscopy. 60: 357-373. PMID 8525549 DOI: 10.1016/0304-3991(95)00082-8  1
1995 Nogales E, Wolf SG, Khan IA, Ludueña RF, Downing KH. Structure of tubulin at 6.5 A and location of the taxol-binding site. Nature. 375: 424-7. PMID 7760939 DOI: 10.1038/375424a0  1
1995 Hud NV, Downing KH, Balhorn R. A constant radius of curvature model for the organization of DNA in toroidal condensates. Proceedings of the National Academy of Sciences of the United States of America. 92: 3581-5. PMID 7724602  1
1995 Ray S, Wolf SG, Howard J, Downing KH. Kinesin does not support the motility of zinc-macrotubes. Cell Motility and the Cytoskeleton. 30: 146-52. PMID 7606807 DOI: 10.1002/cm.970300206  1
1995 Nogales E, Wolf SG, Zhang SX, Downing KH. Preservation of 2-D crystals of tubulin for electron crystallography. Journal of Structural Biology. 115: 199-208. PMID 7577240 DOI: 10.1006/jsbi.1995.1044  1
1995 Perkins GA, Downing KH, Glaeser RM. Crystallographic extraction and averaging of data from small image areas Ultramicroscopy. 60: 283-294. PMID 7502383 DOI: 10.1016/0304-3991(95)00063-5  1
1994 Barnakov AN, Downing KH, Hazelbauer GL. Studies of the structural organization of a bacterial chemoreceptor by electron microscopy Journal of Structural Biology. 112: 117-124. PMID 8060729 DOI: 10.1006/jsbi.1994.1013  1
1993 Hud NV, Allen MJ, Downing KH, Lee J, Balhorn R. Identification of the elemental packing unit of DNA in mammalian sperm cells by atomic force microscopy. Biochemical and Biophysical Research Communications. 193: 1347-54. PMID 8323555 DOI: 10.1006/bbrc.1993.1773  1
1993 Glaeser RM, Downing KH. High-resolution electron crystallography of protein molecules Ultramicroscopy. 52: 478-486. PMID 8116103 DOI: 10.1016/0304-3991(93)90064-5  1
1993 Wolf SG, Mosser G, Downing KH. Tubulin conformation in zinc-induced sheets and macrotubes. Journal of Structural Biology. 111: 190-9. PMID 8003380 DOI: 10.1006/jsbi.1993.1049  1
1992 Glaeser RM, Downing KH. Assessment of resolution in biological electron crystallography Ultramicroscopy. 47: 256-265. PMID 1481279 DOI: 10.1016/0304-3991(92)90201-T  1
1992 Downing KH. Automatic focus correction for spot-scan imaging of tilted specimens Ultramicroscopy. 46: 199-206. PMID 1481271 DOI: 10.1016/0304-3991(92)90015-C  1
1992 Wenk HR, Downing KH, Hu M, O'Keefe MA. 3D structure determination from electron-microscope images: electron crystallography of staurolite. Acta Crystallographica. Section a, Foundations of Crystallography. 48: 700-16. PMID 1445681 DOI: 10.1107/S0108767392000850  1
1992 Downing KH. Three-dimensional crystallographic reconstruction for atomic resolution Scanning Microscopy. Supplement. 6: 43-52. PMID 1366340  1
1992 Downing KH, Jontes J. Projection map of tubulin in zinc-induced sheets at 4 Å resolution Journal of Structural Biology. 109: 152-159. PMID 1288616 DOI: 10.1016/1047-8477(92)90046-D  1
1992 Downing KH, Koster AJ, Typke D. Overview of computer-aided electron microscopy Ultramicroscopy. 46: 189-197. DOI: 10.1016/0304-3991(92)90014-B  1
1991 Glaeser RM, Downing KH, Jap BK. What spectroscopy can still tell us about the secondary structure of bacteriorhodopsin Biophysical Journal. 59: 934-938. PMID 2065193  1
1991 Downing KH. Spot-scan imaging in transmission electron microscopy Science. 251: 53-59. PMID 1846047  1
1991 Sikerwar SS, Downing KH, Glaeser RM. Three-dimensional structure of an invertebrate intercellular communicating junction Journal of Structural Biology. 106: 255-263. PMID 1804280 DOI: 10.1016/1047-8477(91)90075-8  1
1990 Henderson R, Baldwin JM, Ceska TA, Zemlin F, Beckmann E, Downing KH. Model for the structure of bacteriorhodopsin based on high-resolution electron cryo-microscopy. Journal of Molecular Biology. 213: 899-929. PMID 2359127 DOI: 10.1016/S0022-2836(05)80271-2  1
1990 Butt HJ, Downing KH, Hansma PK. Imaging the membrane protein bacteriorhodopsin with the atomic force microscope. Biophysical Journal. 58: 1473-80. PMID 2275963 DOI: 10.1016/S0006-3495(90)82492-9  1
1990 Downing KH, Chiu W. Cold stage design for high resolution electron microscopy of biological materials Electron Microscopy Reviews. 3: 213-226. PMID 2103342 DOI: 10.1016/0892-0354(90)90002-A  1
1990 Henderson R, Baldwin JM, Ceska TA, Zemlin F, Beckmann E, Downing KH. An atomic model for the structure of bacteriorhodopsin. Biochemical Society Transactions. 18: 844. PMID 2083691  1
1990 Jap BK, Downing KH, Walian PJ. Structure of PhoE porin in projection at 3.5 Å resolution Journal of Structural Biology. 103: 57-63. PMID 1697759 DOI: 10.1016/1047-8477(90)90086-R  1
1990 Brillinger DR, Downing KH, Glaeser RM. Some statistical aspects of low-dose electron imaging of crystals Journal of Statistical Planning and Inference. 25: 235-259. DOI: 10.1016/0378-3758(90)90075-6  1
1990 Downing KH, Meisheng H, Wenk HR, O'Keefe MA. Resolution of oxygen atoms in staurolite by three-dimensional transmission electron microscopy Nature. 348: 525-528.  1
1989 Kühlbrandt W, Downing KH. Two-dimensional structure of plant light-harvesting complex at 37 Å resolution by electron crystallography Journal of Molecular Biology. 207: 823-828. PMID 2760931 DOI: 10.1016/0022-2836(89)90247-7  1
1988 Downing KH. Observations of restricted beam-induced specimen motion with small-spot illumination Ultramicroscopy. 24: 387-397. PMID 3363743 DOI: 10.1016/0304-3991(88)90129-5  1
1986 Downing KH, Glaeser RM. Improvement in high resolution image quality of radiation-sensitive specimens achieved with reduced spot size of the electron beam. Ultramicroscopy. 20: 269-78. PMID 3824680 DOI: 10.1016/0304-3991(86)90191-9  1
1986 Dickson MR, Downing KH, Wu WH, Glaeser RM. Three-dimensional structure of the surface layer protein of Aquaspirillum serpens VHA determined by electron crystallography. Journal of Bacteriology. 167: 1025-34. PMID 3745114  1
1986 Henderson R, Baldwin JM, Downing KH, Lepault J, Zemlin F. Structure of purple membrane from halobacterium halobium: recording, measurement and evaluation of electron micrographs at 3.5 Å resolution Ultramicroscopy. 19: 147-178. DOI: 10.1016/0304-3991(86)90203-2  1
1984 Downing KH. Electron crystallographic studies of DNA Ultramicroscopy. 13: 35-46. PMID 6474599 DOI: 10.1016/0304-3991(84)90055-X  1
1983 Chang CF, Williams RC, Grano DA, Downing KH, Glaeser RM. Quantitative evaluation of high-resolution features in images of negatively stained Tobacco Mosaic Virus. Ultramicroscopy. 11: 3-11. PMID 6193626 DOI: 10.1016/0304-3991(83)90050-5  1
1983 Downing KH. Temperature dependence of the critical electron exposure for hydrocarbon monolayers Ultramicroscopy. 11: 229-237. DOI: 10.1016/0304-3991(83)90003-7  1
1982 Downing KH, Grano DA. Analysis of photographic emulsions for electron microscopy of two-dimensional crystalline specimens Ultramicroscopy. 7: 381-403. DOI: 10.1016/0304-3991(82)90262-5  1
1980 Downing KH, Glaeser RM. Electron diffraction from single crystals of DNA. Biophysical Journal. 32: 851-6. PMID 7260304 DOI: 10.1016/S0006-3495(80)85020-X  1
1980 Downing KH, Chiu W. Effect of stray magnetic field on image resolution in transmission electron microscopy Ultramicroscopy. 5: 351-356. DOI: 10.1016/0304-3991(80)90039-X  1
1979 Downing KH. Possibilities of heavy atom discrimination using single-sideband techniques Ultramicroscopy. 4: 13-31. DOI: 10.1016/0304-3991(79)90005-6  1
1978 Frank J, McFarlane SC, Downing KH. NOTE ON THE EFFECT OF ILLUMINATION APERTURE AND DEFOCUS SPREAD IN BRIGHTFIELD ELECTRON MICROSCOPY Optik (Jena). 52: 49-60.  1
1975 Downing KH. NOTE ON TRANSFER FUNCTIONS IN ELECTRON MICROSCOPY WITH TILTED ILLUMINATION Optik (Jena). 43: 199-203.  1
1975 Mueller M, Downing KH, Kuebler O, Koller T. Encapsulation of macromolecules into 'low noise' supports J.Microsc.Biol.Cell.. 23: 117-126.  1
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