Yuh Min Chook, Ph.D - Publications

Pharmacology and Biophysics University of Texas Southwestern Medical Center, Dallas, TX, United States 
Nuclear Transport

29 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2022 Fung HYJ, Chook YM. Crystallization of Nuclear Export Signals or Small-Molecule Inhibitors Bound to Nuclear Exporter CRM1. Methods in Molecular Biology (Clifton, N.J.). 2502: 285-297. PMID 35412246 DOI: 10.1007/978-1-0716-2337-4_19  0.323
2021 Gonzalez A, Mannen T, Çağatay T, Fujiwara A, Matsumura H, Niesman AB, Brautigam CA, Chook YM, Yoshizawa T. Mechanism of karyopherin-β2 binding and nuclear import of ALS variants FUS(P525L) and FUS(R495X). Scientific Reports. 11: 3754. PMID 33580145 DOI: 10.1038/s41598-021-83196-y  0.327
2020 Springhower CE, Rosen MK, Chook YM. Karyopherins and condensates. Current Opinion in Cell Biology. 64: 112-123. PMID 32474299 DOI: 10.1016/J.Ceb.2020.04.003  0.512
2019 Lee Y, Pei J, Baumhardt JM, Chook YM, Grishin NV. Structural prerequisites for CRM1-dependent nuclear export signaling peptides: accessibility, adapting conformation, and the stability at the binding site. Scientific Reports. 9: 6627. PMID 31036839 DOI: 10.1038/S41598-019-43004-0  0.302
2018 Zhang K, Shang G, Padavannil A, Wang J, Sakthivel R, Chen X, Kim M, Thompson MG, García-Sastre A, Lynch KW, Chen ZJ, Chook YM, Fontoura BMA. Structural-functional interactions of NS1-BP protein with the splicing and mRNA export machineries for viral and host gene expression. Proceedings of the National Academy of Sciences of the United States of America. PMID 30538201 DOI: 10.1073/pnas.1818012115  0.615
2018 Fu SC, Fung HYJ, Cağatay T, Baumhardt J, Chook YM. Correlation of CRM1-NES affinity with nuclear export activity. Molecular Biology of the Cell. mbcE18020096. PMID 29927350 DOI: 10.1091/mbc.E18-02-0096  0.307
2018 Pinarbasi ES, Cağatay T, Fung HYJ, Li YC, Chook YM, Thomas PJ. Active nuclear import and passive nuclear export are the primary determinants of TDP-43 localization. Scientific Reports. 8: 7083. PMID 29728608 DOI: 10.1038/S41598-018-25008-4  0.338
2018 Yoshizawa T, Ali R, Jiou J, Fung HYJ, Burke KA, Kim SJ, Lin Y, Peeples WB, Saltzberg D, Soniat M, Baumhardt JM, Oldenbourg R, Sali A, Fawzi NL, Rosen MK, ... Chook YM, et al. Nuclear Import Receptor Inhibits Phase Separation of FUS through Binding to Multiple Sites. Cell. 173: 693-705.e22. PMID 29677513 DOI: 10.1016/J.Cell.2018.03.003  0.529
2018 Guo L, Kim HJ, Wang H, Monaghan J, Freyermuth F, Sung JC, O'Donovan K, Fare CM, Diaz Z, Singh N, Zhang ZC, Coughlin M, Sweeny EA, DeSantis ME, Jackrel ME, ... ... Chook YM, et al. Nuclear-Import Receptors Reverse Aberrant Phase Transitions of RNA-Binding Proteins with Prion-like Domains. Cell. 173: 677-692.e20. PMID 29677512 DOI: 10.1016/J.Cell.2018.03.002  0.475
2018 Chook YM, Fontoura BMA, Rout MP. Günter Blobel 1936-2018. Nature Structural & Molecular Biology. PMID 29610492 DOI: 10.1038/S41594-018-0053-5  0.604
2015 Fung HY, Fu SC, Brautigam CA, Chook YM. Structural determinants of nuclear export signal orientation in binding to exportin CRM1. Elife. 4. PMID 26349033 DOI: 10.7554/Elife.10034  0.315
2015 Soniat M, Chook YM. Nuclear localization signals for four distinct karyopherin-β nuclear import systems. The Biochemical Journal. 468: 353-62. PMID 26173234 DOI: 10.1042/BJ20150368  0.316
2013 Soniat M, Sampathkumar P, Collett G, Gizzi AS, Banu RN, Bhosle RC, Chamala S, Chowdhury S, Fiser A, Glenn AS, Hammonds J, Hillerich B, Khafizov K, Love JD, Matikainen B, ... ... Chook YM, et al. Crystal structure of human Karyopherin β2 bound to the PY-NLS of Saccharomyces cerevisiae Nab2. Journal of Structural and Functional Genomics. 14: 31-5. PMID 23535894 DOI: 10.1007/s10969-013-9150-1  0.391
2013 Sun Q, Carrasco YP, Hu Y, Guo X, Mirzaei H, Macmillan J, Chook YM. Nuclear export inhibition through covalent conjugation and hydrolysis of Leptomycin B by CRM1. Proceedings of the National Academy of Sciences of the United States of America. 110: 1303-8. PMID 23297231 DOI: 10.1073/Pnas.1217203110  0.313
2013 Etchin J, Sun Q, Kentsis A, Farmer A, Zhang ZC, Sanda T, Mansour MR, Barcelo C, McCauley D, Kauffman M, Shacham S, Christie AL, Kung AL, Rodig SJ, Chook YM, et al. Antileukemic activity of nuclear export inhibitors that spare normal hematopoietic cells. Leukemia. 27: 66-74. PMID 22847027 DOI: 10.1038/Leu.2012.219  0.474
2012 Zhang ZC, Chook YM. Structural and energetic basis of ALS-causing mutations in the atypical proline-tyrosine nuclear localization signal of the Fused in Sarcoma protein (FUS). Proceedings of the National Academy of Sciences of the United States of America. 109: 12017-21. PMID 22778397 DOI: 10.1073/pnas.1207247109  0.503
2011 Zhang ZC, Satterly N, Fontoura BM, Chook YM. Evolutionary development of redundant nuclear localization signals in the mRNA export factor NXF1. Molecular Biology of the Cell. 22: 4657-68. PMID 21965294 DOI: 10.1091/mbc.E11-03-0222  0.664
2009 Süel KE, Chook YM. Kap104p imports the PY-NLS-containing transcription factor Tfg2p into the nucleus. The Journal of Biological Chemistry. 284: 15416-24. PMID 19366694 DOI: 10.1074/jbc.M809384200  0.302
2009 Dong X, Biswas A, Chook YM. Structural basis for assembly and disassembly of the CRM1 nuclear export complex. Nature Structural & Molecular Biology. 16: 558-60. PMID 19339972 DOI: 10.1038/nsmb.1586  0.303
2009 Dong X, Biswas A, Süel KE, Jackson LK, Martinez R, Gu H, Chook YM. Structural basis for leucine-rich nuclear export signal recognition by CRM1. Nature. 458: 1136-41. PMID 19339969 DOI: 10.1038/nature07975  0.345
2007 Cansizoglu AE, Lee BJ, Zhang ZC, Fontoura BM, Chook YM. Structure-based design of a pathway-specific nuclear import inhibitor. Nature Structural & Molecular Biology. 14: 452-4. PMID 17435768 DOI: 10.1038/nsmb1229  0.652
2006 Faria AM, Levay A, Wang Y, Kamphorst AO, Rosa ML, Nussenzveig DR, Balkan W, Chook YM, Levy DE, Fontoura BM. The nucleoporin Nup96 is required for proper expression of interferon-regulated proteins and functions. Immunity. 24: 295-304. PMID 16546098 DOI: 10.1016/j.immuni.2006.01.014  0.548
2002 Chook YM, Jung A, Rosen MK, Blobel G. Uncoupling Kapbeta2 substrate dissociation and ran binding. Biochemistry. 41: 6955-66. PMID 12033928 DOI: 10.1021/Bi012122P  0.617
2001 Chook YM, Blobel G. Karyopherins and nuclear import. Current Opinion in Structural Biology. 11: 703-15. PMID 11751052 DOI: 10.1016/S0959-440X(01)00264-0  0.485
1999 Chook YM, Blobel G. Structure of the nuclear transport complex karyopherin-beta2-Ran x GppNHp. Nature. 399: 230-7. PMID 10353245 DOI: 10.1038/20375  0.463
1998 Chook YM, Lipscomb WN, Ke H. Detection and use of pseudo-translation in determination of protein structures. Acta Crystallographica. Section D, Biological Crystallography. 54: 822-7. PMID 9757096 DOI: 10.1107/S0907444997020064  0.429
1994 Chook YM, Gray JV, Ke H, Lipscomb WN. The monofunctional chorismate mutase from Bacillus subtilis. Structure determination of chorismate mutase and its complexes with a transition state analog and prephenate, and implications for the mechanism of the enzymatic reaction. Journal of Molecular Biology. 240: 476-500. PMID 8046752 DOI: 10.1006/Jmbi.1994.1462  0.452
1993 Chook YM, Ke H, Lipscomb WN. Crystal structures of the monofunctional chorismate mutase from Bacillus subtilis and its complex with a transition state analog. Proceedings of the National Academy of Sciences of the United States of America. 90: 8600-3. PMID 8378335 DOI: 10.1073/Pnas.90.18.8600  0.448
1991 Stevens RC, Chook YM, Cho CY, Lipscomb WN, Kantrowitz ER. Escherichia coli aspartate carbamoyltransferase: the probing of crystal structure analysis via site-specific mutagenesis. Protein Engineering. 4: 391-408. PMID 1881865 DOI: 10.1093/Protein/4.4.391  0.628
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