Huib Ovaa - Publications

Affiliations: 
Chemical Immunology Leiden University Medical Center, Leiden, Netherlands 

213 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2021 Rumpret M, von Richthofen HJ, van der Linden M, Westerlaken GHA, Talavera Ormeño C, van Strijp JAG, Landau M, Ovaa H, van Sorge NM, Meyaard L. Signal inhibitory receptor on leukocytes-1 recognizes bacterial and endogenous amphipathic α-helical peptides. Faseb Journal : Official Publication of the Federation of American Societies For Experimental Biology. 35: e21875. PMID 34533845 DOI: 10.1096/fj.202100812R  1
2021 Janssen GV, Zhang S, Merkx R, Schiesswohl C, Chatterjee C, Darwin KH, Geurink PP, Ovaa H, van der Heden van Noort G. Development of Tyrphostin Analogues to Study Inhibition of the Mycobacterium tuberculosis Pup Proteasome System. Chembiochem : a European Journal of Chemical Biology. PMID 34387015 DOI: 10.1002/cbic.202100333  1
2021 Rumpret M, von Richthofen HJ, van der Linden M, Westerlaken GHA, Talavera Ormeño C, Low TY, Ovaa H, Meyaard L. Recognition of S100 proteins by Signal Inhibitory Receptor on Leukocytes-1 negatively regulates human neutrophils. European Journal of Immunology. PMID 34145909 DOI: 10.1002/eji.202149278  1
2021 Gangaev A, Ketelaars SLC, Isaeva OI, Patiwael S, Dopler A, Hoefakker K, De Biasi S, Gibellini L, Mussini C, Guaraldi G, Girardis M, Ormeno CMPT, Hekking PJM, Lardy NM, Toebes M, ... ... Ovaa H, et al. Identification and characterization of a SARS-CoV-2 specific CD8 T cell response with immunodominant features. Nature Communications. 12: 2593. PMID 33972535 DOI: 10.1038/s41467-021-22811-y  1
2021 Mons E, Kim RQ, van Doodewaerd BR, van Veelen PA, Mulder MPC, Ovaa H. Exploring the Versatility of the Covalent Thiol-Alkyne Reaction with Substituted Propargyl Warheads: A Deciding Role for the Cysteine Protease. Journal of the American Chemical Society. 143: 6423-6433. PMID 33885283 DOI: 10.1021/jacs.0c10513  1
2021 Brunner AM, Lössl P, Geurink PP, Ovaa H, Albanese P, Altelaar AFM, Heck AJR, Scheltema RA. Quantifying Positional Isomers (QPI) by top-down mass spectrometry. Molecular & Cellular Proteomics : McP. 100070. PMID 33711480 DOI: 10.1016/j.mcpro.2021.100070  1
2021 Horn-Ghetko D, Krist DT, Prabu JR, Baek K, Mulder MPC, Klügel M, Scott DC, Ovaa H, Kleiger G, Schulman BA. Ubiquitin ligation to F-box protein targets by SCF-RBR E3-E3 super-assembly. Nature. PMID 33536622 DOI: 10.1038/s41586-021-03197-9  1
2021 González-Prieto R, Eifler-Olivi K, Claessens LA, Willemstein E, Xiao Z, Talavera Ormeno CMP, Ovaa H, Ulrich HD, Vertegaal ACO. Global non-covalent SUMO interaction networks reveal SUMO-dependent stabilization of the non-homologous end joining complex. Cell Reports. 34: 108691. PMID 33503430 DOI: 10.1016/j.celrep.2021.108691  1
2021 D'Amico F, Mukhopadhyay R, Ovaa H, Mulder MPC. Targeting TRIM Proteins: A quest towards drugging an emerging protein class. Chembiochem : a European Journal of Chemical Biology. PMID 33482040 DOI: 10.1002/cbic.202000787  1
2020 Liwocha J, Krist DT, van der Heden van Noort GJ, Hansen FM, Truong VH, Karayel O, Purser N, Houston D, Burton N, Bostock MJ, Sattler M, Mann M, Harrison JS, Kleiger G, Ovaa H, et al. Linkage-specific ubiquitin chain formation depends on a lysine hydrocarbon ruler. Nature Chemical Biology. PMID 33288957 DOI: 10.1038/s41589-020-00696-0  1
2020 van Tilburg GBA, Murachelli AG, Fish A, van der Heden van Noort GJ, Ovaa H, Sixma TK. K27-Linked Diubiquitin Inhibits UCHL3 via an Unusual Kinetic Trap. Cell Chemical Biology. PMID 33238157 DOI: 10.1016/j.chembiol.2020.11.005  1
2020 Shin D, Bhattacharya A, Cheng YL, Alonso MC, Mehdipour AR, van der Heden van Noort GJ, Ovaa H, Hummer G, Dikic I. Bacterial OTU deubiquitinases regulate substrate ubiquitination upon infection. Elife. 9. PMID 33185526 DOI: 10.7554/eLife.58277  1
2020 van der Heden van Noort G, Kim RQ, Misra M, Alexis G, Tomašković I, Shin D, Schindelin H, Filippov DV, Ovaa H, Dikic I. Development of ADPribosyl ubiquitin analogs to study enzymes involved in Legionella infection. Chemistry (Weinheim An Der Bergstrasse, Germany). PMID 33075184 DOI: 10.1002/chem.202004590  1
2020 Walser F, Mulder MPC, Bragantini B, Burger S, Gubser T, Gatti M, Botuyan MV, Villa A, Altmeyer M, Neri D, Ovaa H, Mer G, Penengo L. Ubiquitin Phosphorylation at Thr12 Modulates the DNA Damage Response. Molecular Cell. PMID 33022275 DOI: 10.1016/j.molcel.2020.09.017  1
2020 Kooij R, Liu S, Sapmaz A, Xin BT, Janssen GMC, van Veelen PA, Ovaa H, Ten Dijke P, Geurink PP. A Small-Molecule Activity-Based Probe for Monitoring Ubiquitin C-terminal Hydrolase L1 (UCHL1) Activity in Live Cells and Zebrafish Embryos. Journal of the American Chemical Society. PMID 32886496 DOI: 10.1021/Jacs.0C07726  1
2020 Klemm T, Ebert G, Calleja DJ, Allison CC, Richardson LW, Bernardini JP, Lu BG, Kuchel NW, Grohmann C, Shibata Y, Gan ZY, Cooney JP, Doerflinger M, Au AE, Blackmore TR, ... ... Ovaa H, et al. Mechanism and inhibition of the papain-like protease, PLpro, of SARS-CoV-2. The Embo Journal. e106275. PMID 32845033 DOI: 10.15252/Embj.2020106275  1
2020 Shin D, Mukherjee R, Grewe D, Bojkova D, Baek K, Bhattacharya A, Schulz L, Widera M, Mehdipour AR, Tascher G, Geurink PP, Wilhelm A, van der Heden van Noort GJ, Ovaa H, Müller S, et al. Papain-like protease regulates SARS-CoV-2 viral spread and innate immunity. Nature. PMID 32726803 DOI: 10.1038/S41586-020-2601-5  1
2020 Armstrong Z, Kuo CL, Lahav D, Liu B, Johnson R, Beenakker TJM, de Boer C, Wong CS, van Rijssel ER, Debets MF, Florea BI, Hissink C, Boot RG, Geurink PP, Ovaa H, et al. Manno-epi-cyclophellitols Enable Activity-Based Protein Profiling of Human α-Mannosidases and Discovery of New Golgi Mannosidase II Inhibitors. Journal of the American Chemical Society. PMID 32605368 DOI: 10.1021/Jacs.0C03880  1
2020 Schubert AF, Nguyen JV, Franklin TG, Geurink PP, Roberts CG, Sanderson DJ, Miller LN, Ovaa H, Hofmann K, Pruneda JN, Komander D. Identification and characterization of diverse OTU deubiquitinases in bacteria. The Embo Journal. e105127. PMID 32567101 DOI: 10.15252/Embj.2020105127  1
2020 Mulder MPC, Zhuang Z, Liu L, Kessler BM, Ovaa H. Editorial: Probing the Ubiquitin Landscape. Frontiers in Chemistry. 8: 449. PMID 32509738 DOI: 10.3389/Fchem.2020.00449  1
2020 Wössner N, Alhalabi Z, González J, Swyter S, Gan J, Schmidtkunz K, Zhang L, Vaquero A, Ovaa H, Einsle O, Sippl W, Jung M. Sirtuin 1 Inhibiting Thiocyanates (S1th)-A New Class of Isotype Selective Inhibitors of NAD Dependent Lysine Deacetylases. Frontiers in Oncology. 10: 657. PMID 32426286 DOI: 10.3389/Fonc.2020.00657  1
2020 van der Heden van Noort G, Madern JM, Kim RQ, Misra M, Dikic I, Zhang Y, Ovaa H, Codee JDC, Filippov DV. Synthesis of Stable NAD+ Mimics as Inhibitors for the Legionella pneumophila Phosphoribosyl Ubiquitinating Enzyme SdeC. Chembiochem : a European Journal of Chemical Biology. PMID 32421893 DOI: 10.1002/Cbic.202000230  1
2020 van der Zanden SY, Luimstra JJ, Neefjes J, Borst J, Ovaa H. Opportunities for Small Molecules in Cancer Immunotherapy. Trends in Immunology. PMID 32381382 DOI: 10.1016/J.It.2020.04.004  1
2020 Wu HQ, Baker D, Ovaa H. Small molecules that target the ubiquitin system. Biochemical Society Transactions. PMID 32196552 DOI: 10.1042/Bst20190535  0.01
2020 Poramba-Liyanage DW, Korthout T, Cucinotta CE, van Kruijsbergen I, van Welsem T, El Atmioui D, Ovaa H, Tsukiyama T, van Leeuwen F. Inhibition of transcription leads to rewiring of locus-specific chromatin proteomes. Genome Research. PMID 32188699 DOI: 10.1101/Gr.256255.119  1
2020 van Kruijsbergen I, Mulder MPC, Uckelmann M, van Welsem T, de Widt J, Spanjaard A, Jacobs H, El Oualid F, Ovaa H, van Leeuwen F. Strategy for Development of Site-Specific Ubiquitin Antibodies. Frontiers in Chemistry. 8: 111. PMID 32154221 DOI: 10.3389/Fchem.2020.00111  1
2019 Gjonaj L, Sapmaz A, Flierman D, Janssen GMC, van Veelen PA, Ovaa H. Development of a DUB-selective fluorogenic substrate. Chemical Science. 10: 10290-10296. PMID 32110315 DOI: 10.1039/C9Sc02226K  1
2019 Pérez Berrocal DA, Witting KF, Ovaa H, Mulder MPC. Hybrid Chains: A Collaboration of Ubiquitin and Ubiquitin-Like Modifiers Introducing Cross-Functionality to the Ubiquitin Code. Frontiers in Chemistry. 7: 931. PMID 32039151 DOI: 10.3389/Fchem.2019.00931  1
2019 Shahul Hameed D, van Tilburg GBA, Merkx R, Flierman D, Wienk H, El Oualid F, Hofmann K, Boelens R, Ovaa H. Diubiquitin-Based NMR Analysis: Interactions Between Lys6-Linked diUb and UBA Domain of UBXN1. Frontiers in Chemistry. 7: 921. PMID 32039147 DOI: 10.3389/Fchem.2019.00921  1
2019 Liu S, González Prieto R, Zhang M, Geurink PP, Kooij R, Iyengar PV, van Dinther M, Bos E, Zhang X, Le Dévédec SE, van de Water B, Koning RI, Zhu HJ, Mesker WE, Vertegaal A, ... Ovaa H, et al. Deubiquitinase activity profiling identifies UCHL1 as a candidate oncoprotein that promotes TGFβ-induced breast cancer metastasis. Clinical Cancer Research : An Official Journal of the American Association For Cancer Research. PMID 31857432 DOI: 10.1158/1078-0432.Ccr-19-1373  1
2019 Xin BT, Jin G, Fernandez DJ, Knobeloch KP, Geurink PP, Ovaa H. Total chemical synthesis of murine ISG15 and an activity-based probe with physiological binding properties. Organic & Biomolecular Chemistry. PMID 31710063 DOI: 10.1039/C9Ob02127B  1
2019 Mulder MPC, Witting KF, Ovaa H. Cracking the Ubiquitin Code: The Ubiquitin Toolbox. Current Issues in Molecular Biology. 37: 1-20. PMID 31674341 DOI: 10.21775/Cimb.037.001  1
2019 Karpiyevich M, Adjalley S, Mol M, Ascher DB, Mason B, van der Heden van Noort GJ, Laman H, Ovaa H, Lee MCS, Artavanis-Tsakonas K. Nedd8 hydrolysis by UCH proteases in Plasmodium parasites. Plos Pathogens. 15: e1008086. PMID 31658303 DOI: 10.1371/Journal.Ppat.1008086  1
2019 Luimstra JJ, Franken KLMC, Garstka MA, Drijfhout JW, Neefjes J, Ovaa H. Production and Thermal Exchange of Conditional Peptide-MHC I Multimers. Current Protocols in Immunology. 126. PMID 31483102 DOI: 10.1002/Cpim.85  1
2019 Schipper-Krom S, Sanz AS, van Bodegraven EJ, Speijer D, Florea BI, Ovaa H, Reits EA. Visualizing Proteasome Activity and Intracellular Localization Using Fluorescent Proteins and Activity-Based Probes. Frontiers in Molecular Biosciences. 6: 56. PMID 31482094 DOI: 10.3389/Fmolb.2019.00056  1
2019 Hameed DS, Sapmaz A, Burggraaff L, Amore A, Slingerland CJ, van Westen GJP, Ovaa H. Development of a Ubiquitin based probe for metalloprotease deubiquitinases. Angewandte Chemie (International Ed. in English). PMID 31381834 DOI: 10.1002/Anie.201906790  1
2019 Jia Y, Claessens LA, Vertegaal ACO, Ovaa H. Chemical Tools and Biochemical Assays for SUMO Specific Proteases (SENPs). Acs Chemical Biology. PMID 31361113 DOI: 10.1021/Acschembio.9B00402  1
2019 Narasimhan S, Scherpe S, Lucini Paioni A, van der Zwan J, Folkers GE, Ovaa H, Baldus M. DNP supported solid-state NMR of proteins inside Mammalian Cells. Angewandte Chemie (International Ed. in English). PMID 31233270 DOI: 10.1002/anie.201903246  0.01
2019 Resnick E, Bradley A, Gan J, Douangamath A, Krojer T, Sethi R, Geurink PP, Aimon A, Amitai G, Bellini D, Bennett J, Fairhead M, Fedorov O, Gabizon R, Gan J, ... ... Ovaa H, et al. Rapid covalent-probe discovery by electrophile-fragment screening. Journal of the American Chemical Society. PMID 31060360 DOI: 10.1021/Jacs.9B02822  1
2019 Spits M, Janssen LJ, Voortman LM, Kooij R, Neefjes ACM, Ovaa H, Neefjes J. Homeostasis of soluble proteins and the proteasome post nuclear envelope reformation in mitosis. Journal of Cell Science. 132. PMID 30992344 DOI: 10.1242/Jcs.225524  1
2019 Gjonaj L, Sapmaz A, González-Prieto R, Vertegaal ACO, Flierman D, Ovaa H. USP7: combining tools towards selectivity. Chemical Communications (Cambridge, England). 55: 5075-5078. PMID 30972393 DOI: 10.1039/C9Cc00969H  1
2019 Gan J, Leestemaker Y, Sapmaz A, Ovaa H. Highlighting the Proteasome: Using Fluorescence to Visualize Proteasome Activity and Distribution. Frontiers in Molecular Biosciences. 6: 14. PMID 30968028 DOI: 10.3389/Fmolb.2019.00014  1
2019 Sapmaz A, Berlin I, Bos E, Wijdeven RH, Janssen H, Konietzny R, Akkermans JJ, Erson-Bensan AE, Koning RI, Kessler BM, Neefjes J, Ovaa H. USP32 regulates late endosomal transport and recycling through deubiquitylation of Rab7. Nature Communications. 10: 1454. PMID 30926795 DOI: 10.1038/S41467-019-09437-X  1
2019 van der Heden van Noort GJ, Gan J, Ovaa H. Synthetic ubiquitinated proteins meet the proteasome: Distinct roles of ubiquitin in a chain. Proceedings of the National Academy of Sciences of the United States of America. PMID 30926663 DOI: 10.1073/Pnas.1903405116  1
2019 Geurink PP, van der Heden van Noort GJ, Mulder MPC, Knaap RCM, Kikkert M, Ovaa H. Profiling DUBs and Ubl-specific proteases with activity-based probes. Methods in Enzymology. 618: 357-387. PMID 30850060 DOI: 10.1016/Bs.Mie.2018.12.037  1
2019 Mons E, Jansen IDC, Loboda J, van Doodewaerd BR, Hermans J, Verdoes M, van Boeckel CAA, van Veelen PA, Turk B, Turk D, Ovaa H. The Alkyne Moiety as a Latent Electrophile in Irreversible Covalent Small Molecule Inhibitors of Cathepsin K. Journal of the American Chemical Society. 141: 3507-3514. PMID 30689386 DOI: 10.1021/Jacs.8B11027  1
2019 van der Kant R, Langness VF, Herrera CM, Williams DA, Fong LK, Leestemaker Y, Steenvoorden E, Rynearson KD, Brouwers JF, Helms JB, Ovaa H, Giera M, Wagner SL, Bang AG, Goldstein LSB. Cholesterol Metabolism Is a Druggable Axis that Independently Regulates Tau and Amyloid-β in iPSC-Derived Alzheimer's Disease Neurons. Cell Stem Cell. PMID 30686764 DOI: 10.1016/J.Stem.2018.12.013  1
2019 Kim RQ, Geurink PP, Mulder MPC, Fish A, Ekkebus R, El Oualid F, van Dijk WJ, van Dalen D, Ovaa H, van Ingen H, Sixma TK. Kinetic analysis of multistep USP7 mechanism shows critical role for target protein in activity. Nature Communications. 10: 231. PMID 30651545 DOI: 10.1038/S41467-018-08231-5  1
2019 Liebelt F, Sebastian RM, Moore CL, Mulder MPC, Ovaa H, Shoulders MD, Vertegaal ACO. SUMOylation and the HSF1-Regulated Chaperone Network Converge to Promote Proteostasis in Response to Heat Shock. Cell Reports. 26: 236-249.e4. PMID 30605679 DOI: 10.1016/J.Celrep.2018.12.027  1
2019 Heijkants R, Teunisse A, de Vries J, Ovaa H, Jochemsen A. Selective PKCδ Inhibitor B106 Elicits Uveal Melanoma Growth Inhibitory Effects Independent of Activated PKC Isoforms. Acs Chemical Biology. 14: 132-136. PMID 30525429 DOI: 10.1021/Acschembio.8B00292  1
2019 van der Heden van Noort GJ, Talavera Ormeño C, van Dalen D, Ovaa H. One-Step Chemical Synthesis of Native Met1-Linked Poly-Ubiquitin Chains. Chembiochem : a European Journal of Chemical Biology. 20: 62-65. PMID 30264452 DOI: 10.1002/Cbic.201800520  1
2019 van der Heden van Noort GJ, Ovaa H. How to Target Viral and Bacterial Effector Proteins Interfering with Ubiquitin Signaling. Current Topics in Microbiology and Immunology. 420: 111-130. PMID 30178261 DOI: 10.1007/82_2018_134  1
2018 Hameed DS, Sapmaz A, Gjonaj L, Merkx R, Ovaa H. Enhanced Delivery of Synthetic Labelled Ubiquitin into Live Cells by Using Next-Generation Ub-TAT Conjugates. Chembiochem : a European Journal of Chemical Biology. 19: 2553-2557. PMID 30351505 DOI: 10.1002/Cbic.201800649  1
2018 van Tol BDM, Geurink PP, Ovaa H. A MALDI-TOF Approach to Ubiquitin Ligase Activity. Cell Chemical Biology. 25: 1053-1055. PMID 30241600 DOI: 10.1016/J.Chembiol.2018.09.002  1
2018 van Welsem T, Korthout T, Ekkebus R, Morais D, Molenaar TM, van Harten K, Poramba-Liyanage DW, Sun SM, Lenstra TL, Srivas R, Ideker T, Holstege FCP, van Attikum H, El Oualid F, Ovaa H, et al. Dot1 promotes H2B ubiquitination by a methyltransferase-independent mechanism. Nucleic Acids Research. PMID 30203048 DOI: 10.1093/Nar/Gky801  1
2018 Witting K, van der Heden van Noort G, Kofoed C, Talavera Ormeno C, El Atmioui D, Mulder MPC, Ovaa H. Generation of the UFM1 toolkit for profiling UFM1-specific proteases and ligases. Angewandte Chemie (International Ed. in English). PMID 30188611 DOI: 10.1002/Anie.201809232  1
2018 Xin BT, van Tol BDM, Ovaa H, Geurink PP. Native chemical ligation at methionine bioisostere norleucine allows for N-terminal chemical protein ligation. Organic & Biomolecular Chemistry. PMID 30117511 DOI: 10.1039/C8Ob01627E  1
2018 Mulder MPC, Merkx R, Witting K, Hameed D, El Atmioui D, Lelieveld L, Liebelt F, Neefjes J, Berlin I, Vertegaal A, Ovaa H. Total chemical synthesis of SUMO and SUMO ABPs to profile activity of SUMO-specific proteases. Angewandte Chemie (International Ed. in English). PMID 29771001 DOI: 10.1002/Anie.201803483  1
2018 Liepe J, Ovaa H, Mishto M. Why do proteases mess up with antigen presentation by re-shuffling antigen sequences? Current Opinion in Immunology. 52: 81-86. PMID 29723668 DOI: 10.1016/J.Coi.2018.04.016  1
2018 Luimstra JJ, Garstka MA, Roex MCJ, Redeker A, Janssen GMC, van Veelen PA, Arens R, Falkenburg JHF, Neefjes J, Ovaa H. A flexible MHC class I multimer loading system for large-scale detection of antigen-specific T cells. The Journal of Experimental Medicine. PMID 29666167 DOI: 10.1084/Jem.20180156  1
2018 Ovaa H, Vertegaal ACO. Probing ubiquitin and SUMO conjugation and deconjugation. Biochemical Society Transactions. 46: 423-436. PMID 29588386 DOI: 10.1042/Bst20170086  1
2018 Eifler K, Cuijpers SAG, Willemstein E, Raaijmakers JA, El Atmioui D, Ovaa H, Medema RH, Vertegaal ACO. SUMO targets the APC/C to regulate transition from metaphase to anaphase. Nature Communications. 9: 1119. PMID 29549242 DOI: 10.1038/S41467-018-03486-4  1
2018 Hermanns T, Pichlo C, Woiwode I, Klopffleisch K, Witting KF, Ovaa H, Baumann U, Hofmann K. A family of unconventional deubiquitinases with modular chain specificity determinants. Nature Communications. 9: 799. PMID 29476094 DOI: 10.1038/S41467-018-03148-5  1
2018 Swatek KN, Aumayr M, Pruneda JN, Visser LJ, Berryman S, Kueck AF, Geurink PP, Ovaa H, van Kuppeveld FJM, Tuthill TJ, Skern T, Komander D. Irreversible inactivation of ISG15 by a viral leader protease enables alternative infection detection strategies. Proceedings of the National Academy of Sciences of the United States of America. PMID 29463763 DOI: 10.1073/Pnas.1710617115  1
2018 Zhang X, Smits AH, van Tilburg GB, Ovaa H, Huber W, Vermeulen M. Proteome-wide identification of ubiquitin interactions using UbIA-MS. Nature Protocols. 13: 530-550. PMID 29446774 DOI: 10.1038/Nprot.2017.147  1
2018 Oerlemans R, Berkers CR, Assaraf YG, Scheffer GL, Peters GJ, Verbrugge SE, Cloos J, Slootstra J, Meloen RH, Shoemaker RH, Dijkmans BAC, Scheper RJ, Ovaa H, Jansen G. Proteasome inhibition and mechanism of resistance to a synthetic, library-based hexapeptide. Investigational New Drugs. PMID 29442210 DOI: 10.1007/S10637-018-0569-X  1
2018 Juenemann K, Jansen AHP, van Riel L, Merkx R, Mulder MPC, An H, Statsyuk A, Kirstein J, Ovaa H, Reits EA. Dynamic recruitment of ubiquitin to mutant huntingtin inclusion bodies. Scientific Reports. 8: 1405. PMID 29362455 DOI: 10.1038/S41598-018-19538-0  1
2018 Janssen GV, van den Heuvel JAC, Megens RP, Benningshof JCJ, Ovaa H. Microwave-assisted diastereoselective two-step three-component synthesis for rapid access to drug-like libraries of substituted 3-amino-β-lactams. Bioorganic & Medicinal Chemistry. 26: 41-49. PMID 29174508 DOI: 10.1016/J.Bmc.2017.11.014  1
2017 Palmer AL, de Jong A, Leestemaker Y, Geurink PP, Wijdeven RH, Ovaa H, Dolan BP. Inhibition of the Deubiquitinase Usp14 Diminishes Direct MHC Class I Antigen Presentation. Journal of Immunology (Baltimore, Md. : 1950). PMID 29282303 DOI: 10.4049/Jimmunol.1700273  1
2017 Leestemaker Y, Ovaa H. Tools to investigate the ubiquitin proteasome system. Drug Discovery Today. Technologies. 26: 25-31. PMID 29249239 DOI: 10.1016/J.Ddtec.2017.11.006  1
2017 Liu Q, Kistemaker HAV, Bhogaraju S, Dikic I, Overkleeft HS, van der Marel GA, Ovaa H, van der Heden van Noort G, Filippov DV. A General Approach Towards Triazole-linked Adenosine Diphosphate Ribosylated Peptides and Proteins. Angewandte Chemie (International Ed. in English). PMID 29215186 DOI: 10.1002/Anie.201710527  1
2017 van der Heden van Noort GJ, Kooij R, Elliott PR, Komander D, Ovaa H. Synthesis of Poly-Ubiquitin Chains Using a Bifunctional Ubiquitin Monomer. Organic Letters. 19: 6490-6493. PMID 29172548 DOI: 10.1021/Acs.Orglett.7B03085  1
2017 Dohmen AJC, Qiao X, Duursma A, Wijdeven RH, Lieftink C, Hageman F, Morris B, Halonen P, Vens C, van den Brekel MWM, Ovaa H, Neefjes J, Zuur CL. Identification of a novel ATM inhibitor with cancer cell specific radiosensitization activity. Oncotarget. 8: 73925-73937. PMID 29088757 DOI: 10.18632/Oncotarget.18034  1
2017 van Nuland M, Rosing H, de Vries J, Ovaa H, Schellens JHM, Beijnen JH. An LC-MS/MS method for quantification of the active abiraterone metabolite Δ(4)-abiraterone (D4A) in human plasma. Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences. 1068: 119-124. PMID 29059586 DOI: 10.1016/J.Jchromb.2017.10.033  1
2017 Lahav D, Liu B, van den Berg RJBHN, van den Nieuwendijk AMCH, Wennekes T, Ghisaidoobe AT, Breen I, Ferraz MJ, Kuo CL, Wu L, Geurink PP, Ovaa H, van der Marel GA, van der Stelt M, Boot RG, et al. A Fluorescence Polarization Activity-Based Protein Profiling Assay in the Discovery of Potent, Selective Inhibitors for Human Non-lysosomal Glucosylceramidase. Journal of the American Chemical Society. PMID 28937220 DOI: 10.1021/Jacs.7B07352  1
2017 Widjaja CE, Olvera JG, Metz PJ, Phan AT, Savas JN, de Bruin G, Leestemaker Y, Berkers CR, de Jong A, Florea BI, Fisch K, Lopez J, Kim SH, Garcia DA, Searles S, ... ... Ovaa H, et al. Proteasome activity regulates CD8+ T lymphocyte metabolism and fate specification. The Journal of Clinical Investigation. PMID 28846070 DOI: 10.1172/Jci90895  1
2017 de Jong A, Witting K, Kooij R, Flierman D, Ovaa H. Release of Enzymatically Active Deubiquitinating Enzymes upon Reversible Capture by Disulfide Ubiquitin Reagents. Angewandte Chemie (International Ed. in English). PMID 28841265 DOI: 10.1002/Anie.201706738  1
2017 Leney AC, El Atmioui D, Wu W, Ovaa H, Heck AJR. Elucidating crosstalk mechanisms between phosphorylation and O-GlcNAcylation. Proceedings of the National Academy of Sciences of the United States of America. PMID 28808029 DOI: 10.1073/Pnas.1620529114  1
2017 Leestemaker Y, de Jong A, Witting KF, Penning R, Schuurman K, Rodenko B, Zaal EA, van de Kooij B, Laufer S, Heck AJR, Borst J, Scheper W, Berkers CR, Ovaa H. Proteasome Activation by Small Molecules. Cell Chemical Biology. PMID 28552582 DOI: 10.1016/J.Chembiol.2017.05.010  1
2017 Witting KF, Mulder MPC, Ovaa H. Advancing our understanding of ubiquitination using the Ub-Toolkit. Journal of Molecular Biology. PMID 28410891 DOI: 10.1016/J.Jmb.2017.04.002  1
2017 Chojnacki M, Mansour W, Hameed DS, Singh RK, El Oualid F, Rosenzweig R, Nakasone MA, Yu Z, Glaser F, Kay LE, Fushman D, Ovaa H, Glickman MH. Polyubiquitin-Photoactivatable Crosslinking Reagents for Mapping Ubiquitin Interactome Identify Rpn1 as a Proteasome Ubiquitin-Associating Subunit. Cell Chemical Biology. PMID 28330605 DOI: 10.1016/J.Chembiol.2017.02.013  1
2017 Zhang S, Burns-Huang KE, Janssen GV, Li H, Ovaa H, Hedstrom L, Darwin KH. Mycobacterium tuberculosis Proteasome Accessory Factor A (PafA) Can Transfer Prokaryotic Ubiquitin-Like Protein (Pup) between Substrates. Mbio. 8. PMID 28223451 DOI: 10.1128/Mbio.00122-17  1
2017 Zhang X, Smits AH, van Tilburg GB, Jansen PW, Makowski MM, Ovaa H, Vermeulen M. An Interaction Landscape of Ubiquitin Signaling. Molecular Cell. PMID 28190767 DOI: 10.1016/J.Molcel.2017.01.004  1
2017 Basters A, Geurink PP, Röcker A, Witting KF, Tadayon R, Hess S, Semrau MS, Storici P, Ovaa H, Knobeloch KP, Fritz G. Structural basis of the specificity of USP18 toward ISG15. Nature Structural & Molecular Biology. PMID 28165509 DOI: 10.1038/Nsmb.3371  1
2017 Leestemaker Y, de Jong A, Ovaa H. Profiling the Activity of Deubiquitinating Enzymes Using Chemically Synthesized Ubiquitin-Based Probes. Methods in Molecular Biology (Clifton, N.J.). 1491: 113-130. PMID 27778285 DOI: 10.1007/978-1-4939-6439-0_9  1
2017 Hameed DS, Sapmaz A, Ovaa H. How Chemical Synthesis of Ubiquitin Conjugates Helps To Understand Ubiquitin Signal Transduction. Bioconjugate Chemistry. 28: 805-815. PMID 27077728 DOI: 10.1021/Acs.Bioconjchem.6B00140  1
2016 Shah P, Cheasty A, Foxton C, Raynham T, Farooq M, Gutierrez IF, Lejeune A, Pritchard M, Turnbull A, Pang L, Owen P, Boyd S, Stowell A, Jordan A, Hamilton NM, ... ... Ovaa H, et al. Discovery of potent inhibitors of the lysophospholipase autotaxin. Bioorganic & Medicinal Chemistry Letters. PMID 27780639 DOI: 10.1016/J.Bmcl.2016.10.036  1
2016 Mevissen TE, Kulathu Y, Mulder MP, Geurink PP, Maslen SL, Gersch M, Elliott PR, Burke JE, van Tol BD, Akutsu M, El Oualid F, Kawasaki M, Freund SM, Ovaa H, Komander D. Molecular basis of Lys11-polyubiquitin specificity in the deubiquitinase Cezanne. Nature. PMID 27732584 DOI: 10.1038/Nature19836  1
2016 Platteel AC, Marit de Groot A, Keller C, Andersen P, Ovaa H, Kloetzel PM, Mishto M, Sijts AJ. Strategies to enhance immunogenicity of cDNA vaccine encoded antigens by modulation of antigen processing. Vaccine. PMID 27593157 DOI: 10.1016/J.Vaccine.2016.08.039  1
2016 Scott DC, Rhee DY, Duda DM, Kelsall IR, Olszewski JL, Paulo JA, de Jong A, Ovaa H, Alpi AF, Harper JW, Schulman BA. Two Distinct Types of E3 Ligases Work in Unison to Regulate Substrate Ubiquitylation. Cell. 166: 1198-1214.e24. PMID 27565346 DOI: 10.1016/J.Cell.2016.07.027  1
2016 Pruneda JN, Durkin CH, Geurink PP, Ovaa H, Santhanam B, Holden DW, Komander D. The Molecular Basis for Ubiquitin and Ubiquitin-like Specificities in Bacterial Effector Proteases. Molecular Cell. PMID 27425412 DOI: 10.1016/J.Molcel.2016.06.015  1
2016 Rosendahl Huber SK, Luimstra JJ, van Beek J, Hoppes R, Jacobi RH, Hendriks M, Kapteijn K, Ouwerkerk C, Rodenko B, Ovaa H, de Jonge J. Chemical Modification of Influenza CD8+ T-Cell Epitopes Enhances Their Immunogenicity Regardless of Immunodominance. Plos One. 11: e0156462. PMID 27333291 DOI: 10.1371/Journal.Pone.0156462  1
2016 van Tilburg GB, Elhebieshy AF, Ovaa H. Synthetic and semi-synthetic strategies to study ubiquitin signaling. Current Opinion in Structural Biology. 38: 92-101. PMID 27315041 DOI: 10.1016/J.Sbi.2016.05.022  1
2016 Békés M, van der Heden van Noort GJ, Ekkebus R, Ovaa H, Huang TT, Lima CD. Recognition of Lys48-Linked Di-ubiquitin and Deubiquitinating Activities of the SARS Coronavirus Papain-like Protease. Molecular Cell. 62: 572-585. PMID 27203180 DOI: 10.1016/J.Molcel.2016.04.016  1
2016 Mulder MP, Witting K, Berlin I, Pruneda JN, Wu KP, Chang JG, Merkx R, Bialas J, Groettrup M, Vertegaal AC, Schulman BA, Komander D, Neefjes J, El Oualid F, Ovaa H. A cascading activity-based probe sequentially targets E1-E2-E3 ubiquitin enzymes. Nature Chemical Biology. PMID 27182664 DOI: 10.1038/Nchembio.2084  1
2016 Flierman D, van der Heden van Noort GJ, Ekkebus R, Geurink PP, Mevissen TE, Hospenthal MK, Komander D, Ovaa H. Non-hydrolyzable Diubiquitin Probes Reveal Linkage-Specific Reactivity of Deubiquitylating Enzymes Mediated by S2 Pockets. Cell Chemical Biology. 23: 472-82. PMID 27066941 DOI: 10.1016/J.Chembiol.2016.03.009  1
2016 Geurink PP, van Tol BD, van Dalen D, Brundel PJ, Mevissen TE, Pruneda JN, Elliott PR, van Tilburg GB, Komander D, Ovaa H. Development of Diubiquitin-Based FRET Probes To Quantify Ubiquitin Linkage Specificity of Deubiquitinating Enzymes. Chembiochem : a European Journal of Chemical Biology. PMID 26996281 DOI: 10.1002/Cbic.201600017  1
2016 Banno A, Garcia DA, van Baarsel ED, Metz PJ, Fisch K, Widjaja CE, Kim SH, Lopez J, Chang AN, Geurink PP, Florea BI, Overkleeft HS, Ovaa H, Bui JD, Yang J, et al. Downregulation of 26S proteasome catalytic activity promotes epithelial-mesenchymal transition. Oncotarget. PMID 26930717 DOI: 10.18632/Oncotarget.7596  1
2016 Sahtoe DD, van Dijk WJ, Ekkebus R, Ovaa H, Sixma TK. BAP1/ASXL1 recruitment and activation for H2A deubiquitination. Nature Communications. 7: 10292. PMID 26739236 DOI: 10.1038/Ncomms10292  1
2016 Bekes M, Ekkebus R, Noort GJvdHv, Ovaa H, Huang TT, Lima CD. Structural basis for the diUb-Lys48 recognition and specificity of the SARS coronavirus deubiquitinating enzyme, SARS PLpro Molecular Cell. 62. DOI: 10.2210/Pdb5E6J/Pdb  1
2015 Nelson JK, Cook EC, Loregger A, Hoeksema MA, Scheij S, Kovacevic I, Hordijk PL, Ovaa H, Zelcer N. De-ubiquitylase inhibition reveals LXR-independent transcriptional regulation of the E3 ubiquitin ligase IDOL and lipoprotein uptake. The Journal of Biological Chemistry. PMID 26719329 DOI: 10.1074/Jbc.M115.698688  1
2015 Leestemaker Y, Ovaa H. Hitting the target. Nature Methods. 12: 1127-8. PMID 26624797 DOI: 10.1038/Nmeth.3660  1
2015 Navarro-Yepes J, Anandhan A, Bradley E, Bohovych I, Yarabe B, de Jong A, Ovaa H, Zhou Y, Khalimonchuk O, Quintanilla-Vega B, Franco R. Inhibition of Protein Ubiquitination by Paraquat and 1-Methyl-4-Phenylpyridinium Impairs Ubiquitin-Dependent Protein Degradation Pathways. Molecular Neurobiology. PMID 26409479 DOI: 10.1007/S12035-015-9414-9  1
2015 Berkers CR, de Jong A, Schuurman KG, Linnemann C, Meiring HD, Janssen L, Neefjes JJ, Schumacher TN, Rodenko B, Ovaa H. Definition of Proteasomal Peptide Splicing Rules for High-Efficiency Spliced Peptide Presentation by MHC Class I Molecules. Journal of Immunology (Baltimore, Md. : 1950). PMID 26401003 DOI: 10.4049/Jimmunol.1402455  1
2015 Berkers CR, de Jong A, Schuurman KG, Linnemann C, Geenevasen JA, Schumacher TN, Rodenko B, Ovaa H. Peptide Splicing in the Proteasome Creates a Novel Type of Antigen with an Isopeptide Linkage. Journal of Immunology (Baltimore, Md. : 1950). 195: 4075-84. PMID 26401000 DOI: 10.4049/Jimmunol.1402454  1
2014 Groettrup M, Ovaa H. Editorial overview: Molecular immunology: targeting the immune system. Current Opinion in Chemical Biology. 23. PMID 25467126 DOI: 10.1016/J.Cbpa.2014.10.012  0.01
2014 Ekkebus R, Flierman D, Geurink PP, Ovaa H. Catching a DUB in the act: novel ubiquitin-based active site directed probes. Current Opinion in Chemical Biology. 23: 63-70. PMID 25461387 DOI: 10.1016/J.Cbpa.2014.10.005  1
2014 van Kasteren SI, Overkleeft H, Ovaa H, Neefjes J. Chemical biology of antigen presentation by MHC molecules Current Opinion in Immunology. 26: 21-31. PMID 24556397 DOI: 10.1016/J.Coi.2013.10.005  1
2014 Wijdeven RH, Neefjes J, Ovaa H. How chemistry supports cell biology: The chemical toolbox at your service Trends in Cell Biology. 24: 751-760. DOI: 10.1016/J.Tcb.2014.07.002  1
2013 Neefjes J, Ovaa H. A peptide's perspective on antigen presentation to the immune system Nature Chemical Biology. 9: 769-775. PMID 24231618 DOI: 10.1038/Nchembio.1391  1
2013 Gao Y, Koppen A, Rakhshandehroo M, Tasdelen I, van de Graaf SF, van Loosdregt J, van Beekum O, Hamers N, van Leenen D, Berkers CR, Berger R, Holstege FC, Coffer PJ, Brenkman AB, Ovaa H, et al. Early adipogenesis is regulated through USP7-mediated deubiquitination of the histone acetyltransferase TIP60. Nature Communications. 4: 2656. PMID 24141283 DOI: 10.1038/Ncomms3656  1
2013 Smit JJ, van Dijk WJ, El Atmioui D, Merkx R, Ovaa H, Sixma TK. Target specificity of the E3 ligase LUBAC for ubiquitin and NEMO relies on different minimal requirements. The Journal of Biological Chemistry. 288: 31728-37. PMID 24030825 DOI: 10.1074/Jbc.M113.495846  1
2013 van Loosdregt J, Fleskens V, Fu J, Brenkman AB, Bekker CP, Pals CE, Meerding J, Berkers CR, Barbi J, Gröne A, Sijts AJ, Maurice MM, Kalkhoven E, Prakken BJ, Ovaa H, et al. Stabilization of the transcription factor Foxp3 by the deubiquitinase USP7 increases Treg-cell-suppressive capacity. Immunity. 39: 259-71. PMID 23973222 DOI: 10.1016/J.Immuni.2013.05.018  1
2013 Mevissen TE, Hospenthal MK, Geurink PP, Elliott PR, Akutsu M, Arnaudo N, Ekkebus R, Kulathu Y, Wauer T, El Oualid F, Freund SM, Ovaa H, Komander D. OTU deubiquitinases reveal mechanisms of linkage specificity and enable ubiquitin chain restriction analysis. Cell. 154: 169-84. PMID 23827681 DOI: 10.1016/J.Cell.2013.05.046  1
2013 Pang B, Qiao X, Janssen L, Velds A, Groothuis T, Kerkhoven R, Nieuwland M, Ovaa H, Rottenberg S, van Tellingen O, Janssen J, Huijgens P, Zwart W, Neefjes J. Drug-induced histone eviction from open chromatin contributes to the chemotherapeutic effects of doxorubicin. Nature Communications. 4: 1908. PMID 23715267 DOI: 10.1038/Ncomms2921  1
2013 Miyabe Y, Miyabe C, Iwai Y, Takayasu A, Fukuda S, Yokoyama W, Nagai J, Jona M, Tokuhara Y, Ohkawa R, Albers HM, Ovaa H, Aoki J, Chun J, Yatomi Y, et al. Necessity of lysophosphatidic acid receptor 1 for development of arthritis. Arthritis and Rheumatism. 65: 2037-47. PMID 23666827 DOI: 10.1002/Art.37991  1
2013 Orre M, Kamphuis W, Dooves S, Kooijman L, Chan ET, Kirk CJ, Dimayuga Smith V, Koot S, Mamber C, Jansen AH, Ovaa H, Hol EM. Reactive glia show increased immunoproteasome activity in Alzheimer's disease. Brain : a Journal of Neurology. 136: 1415-31. PMID 23604491 DOI: 10.1093/Brain/Awt083  1
2013 Ekkebus R, van Kasteren SI, Kulathu Y, Scholten A, Berlin I, Geurink PP, de Jong A, Goerdayal S, Neefjes J, Heck AJ, Komander D, Ovaa H. On terminal alkynes that can react with active-site cysteine nucleophiles in proteases. Journal of the American Chemical Society. 135: 2867-70. PMID 23387960 DOI: 10.1021/Ja309802N  1
2013 Bai Z, Cai L, Umemoto E, Takeda A, Tohya K, Komai Y, Veeraveedu PT, Hata E, Sugiura Y, Kubo A, Suematsu M, Hayasaka H, Okudaira S, Aoki J, Tanaka T, ... ... Ovaa H, et al. Constitutive lymphocyte transmigration across the basal lamina of high endothelial venules is regulated by the autotaxin/lysophosphatidic acid axis. Journal of Immunology (Baltimore, Md. : 1950). 190: 2036-48. PMID 23365076 DOI: 10.4049/Jimmunol.1202025  1
2013 Amore A, Wals K, Koekoek E, Hoppes R, Toebes M, Schumacher TNM, Rodenko B, Ovaa H. Development of a Hypersensitive Periodate‐Cleavable Amino Acid that is Methionine‐ and Disulfide‐Compatible and its Application in MHC Exchange Reagents for T Cell Characterisation Chembiochem. 14: 123-131. PMID 23280887 DOI: 10.1002/Cbic.201200540  1
2013 Hoppes R, Lokhorst H, Spaapen RM, Ovaa H, Mutis T. Improved Vaccine Design For Adoptive Immunotherapy In Hematological Malignancies Through Chemically Modified Minor Histocompatibility Antigen Epitopes Blood. 122: 5435-5435. DOI: 10.1182/Blood.V122.21.5435.5435  1
2013 Merkx R, Bruin Gd, Kruithof A, Bergh Tvd, Snip E, Lutz M, Oualid FE, Ovaa H. Scalable synthesis of γ-thiolysine starting from lysine and a side by side comparison with δ-thiolysine in non-enzymatic ubiquitination Chemical Science. 4: 4494-4498. DOI: 10.1039/C3Sc51599K  1
2012 Lai SL, Yao WL, Tsao KC, Houben AJ, Albers HM, Ovaa H, Moolenaar WH, Lee SJ. Autotaxin/Lpar3 signaling regulates Kupffer's vesicle formation and left-right asymmetry in zebrafish. Development (Cambridge, England). 139: 4439-48. PMID 23095890 DOI: 10.1242/Dev.081745  1
2012 de Jong A, Merkx R, Berlin I, Rodenko B, Wijdeven RH, El Atmioui D, Yalçin Z, Robson CN, Neefjes JJ, Ovaa H. Ubiquitin-based probes prepared by total synthesis to profile the activity of deubiquitinating enzymes. Chembiochem : a European Journal of Chemical Biology. 13: 2251-8. PMID 23011887 DOI: 10.1002/Cbic.201200497  1
2012 Burns KE, McAllister FE, Schwerdtfeger C, Mintseris J, Cerda-Maira F, Noens EE, Wilmanns M, Hubbard SR, Melandri F, Ovaa H, Gygi SP, Darwin KH. Mycobacterium tuberculosis prokaryotic ubiquitin-like protein-deconjugating enzyme is an unusual aspartate amidase. The Journal of Biological Chemistry. 287: 37522-9. PMID 22942282 DOI: 10.1074/Jbc.M112.384784  1
2012 Merkx R, Burns KE, Slobbe P, El Oualid F, El Atmioui D, Darwin KH, Ovaa H. Synthesis and evaluation of a selective fluorogenic Pup derived assay reagent for Dop, a potential drug target in Mycobacterium tuberculosis. Chembiochem : a European Journal of Chemical Biology. 13: 2056-60. PMID 22927162 DOI: 10.1002/Cbic.201200460  1
2012 Schulz S, Chachami G, Kozaczkiewicz L, Winter U, Stankovic-Valentin N, Haas P, Hofmann K, Urlaub H, Ovaa H, Wittbrodt J, Meulmeester E, Melchior F. Ubiquitin-specific protease-like 1 (USPL1) is a SUMO isopeptidase with essential, non-catalytic functions. Embo Reports. 13: 930-8. PMID 22878415 DOI: 10.1038/Embor.2012.125  1
2012 Federico L, Ren H, Mueller PA, Wu T, Liu S, Popovic J, Blalock EM, Sunkara M, Ovaa H, Albers HM, Mills GB, Morris AJ, Smyth SS. Autotaxin and its product lysophosphatidic acid suppress brown adipose differentiation and promote diet-induced obesity in mice. Molecular Endocrinology (Baltimore, Md.). 26: 786-97. PMID 22474126 DOI: 10.1210/Me.2011-1229  1
2012 Berkers CR, Leestemaker Y, Schuurman KG, Ruggeri B, Jones-Bolin S, Williams M, Ovaa H. Probing the specificity and activity profiles of the proteasome inhibitors bortezomib and delanzomib. Molecular Pharmaceutics. 9: 1126-1135. PMID 22432738 DOI: 10.1021/Mp2004143  1
2012 Oualid FE, Hameed DS, Atmioui DE, Hilkmann H, Ovaa H. Synthesis of Atypical Diubiquitin Chains Methods of Molecular Biology. 832: 597-609. PMID 22350915 DOI: 10.1007/978-1-61779-474-2_42  1
2012 Albers HM, Ovaa H. Chemical evolution of autotaxin inhibitors. Chemical Reviews. 112: 2593-603. PMID 22335786 DOI: 10.1021/Cr2003213  1
2012 Licchesi JD, Mieszczanek J, Mevissen TE, Rutherford TJ, Akutsu M, Virdee S, El Oualid F, Chin JW, Ovaa H, Bienz M, Komander D. An ankyrin-repeat ubiquitin-binding domain determines TRABID's specificity for atypical ubiquitin chains. Nature Structural & Molecular Biology. 19: 62-71. PMID 22157957 DOI: 10.1038/Nsmb.2169  1
2012 Jong Ad, Schuurman KG, Rodenko B, Ovaa H, Berkers CR. Fluorescence-based proteasome activity profiling. Methods of Molecular Biology. 803: 183-204. PMID 22065226 DOI: 10.1007/978-1-61779-364-6_13  1
2012 Wijdeven R, Berlin I, Ovaa H, Neefjes J. Finding inhibitors for de-ubiquitinating enzymes (DUBs) that regulate MHCII transcription Molecular Immunology. 51: 36. DOI: 10.1016/J.Molimm.2012.02.104  1
2012 Sadaka C, Gerink P, Rodenko B, Ovaa H, Neefjes J. Identification of “drugable” molecular targets implicated in cross-presentation by dendritic cells Molecular Immunology. 51: 29. DOI: 10.1016/J.Molimm.2012.02.079  1
2012 Amore A, Wals K, Koekoek E, Hoppes R, Toebes M, Schumacher T, Rodenko B, Ovaa H. A novel chemocleavable linker and its application in MHC class I peptide exchange Molecular Immunology. 51: 6-7. DOI: 10.1016/J.Molimm.2012.02.011  1
2011 Geurink PP, El Oualid F, Jonker A, Hameed DS, Ovaa H. A general chemical ligation approach towards isopeptide-linked ubiquitin and ubiquitin-like assay reagents. Chembiochem : a European Journal of Chemical Biology. 13: 293-7. PMID 22213387 DOI: 10.1002/Cbic.201100706  1
2011 Faesen AC, Luna-Vargas MP, Geurink PP, Clerici M, Merkx R, van Dijk WJ, Hameed DS, El Oualid F, Ovaa H, Sixma TK. The differential modulation of USP activity by internal regulatory domains, interactors and eight ubiquitin chain types. Chemistry & Biology. 18: 1550-61. PMID 22195557 DOI: 10.1016/J.Chembiol.2011.10.017  1
2011 Faesen AC, Dirac AM, Shanmugham A, Ovaa H, Perrakis A, Sixma TK. Mechanism of USP7/HAUSP activation by its C-terminal ubiquitin-like domain and allosteric regulation by GMP-synthetase. Molecular Cell. 44: 147-59. PMID 21981925 DOI: 10.1016/J.Molcel.2011.06.034  1
2011 van Kasteren SI, Berlin I, Colbert JD, Keane D, Ovaa H, Watts C. A multifunctional protease inhibitor to regulate endolysosomal function. Acs Chemical Biology. 6: 1198-204. PMID 21910425 DOI: 10.1021/Cb200292C  1
2011 Albers HM, Hendrickx LJ, van Tol RJ, Hausmann J, Perrakis A, Ovaa H. Structure-based design of novel boronic acid-based inhibitors of autotaxin. Journal of Medicinal Chemistry. 54: 4619-26. PMID 21615078 DOI: 10.1021/Jm200310Q  1
2011 Paul P, van den Hoorn T, Jongsma ML, Bakker MJ, Hengeveld R, Janssen L, Cresswell P, Egan DA, van Ham M, Ten Brinke A, Ovaa H, Beijersbergen RL, Kuijl C, Neefjes J. A Genome-wide multidimensional RNAi screen reveals pathways controlling MHC class II antigen presentation. Cell. 145: 268-83. PMID 21458045 DOI: 10.1016/J.Cell.2011.03.023  1
2011 Nijholt DAT, Graaf TRd, Haastert ESv, Oliveira AO, Berkers CR, Zwart R, Ovaa H, Baas F, Hoozemans JJM, Scheper W. Endoplasmic reticulum stress activates autophagy but not the proteasome in neuronal cells: implications for Alzheimer's disease Cell Death & Differentiation. 18: 1071-1081. PMID 21252911 DOI: 10.1038/Cdd.2010.176  1
2011 Potts BC, Albitar MX, Anderson KC, Baritaki S, Berkers C, Bonavida B, Chandra J, Chauhan D, Cusack JC, Fenical W, Ghobrial IM, Groll M, Jensen PR, Lam KS, Lloyd GK, ... ... Ovaa H, et al. Marizomib, a proteasome inhibitor for all seasons: preclinical profile and a framework for clinical trials. Current Cancer Drug Targets. 11: 254-84. PMID 21247382 DOI: 10.2174/156800911794519716  1
2011 Frederiks F, Stulemeijer IJE, Ovaa H, Leeuwen Fv. A modified epigenetics toolbox to study histone modifications on the nucleosome core. Chembiochem. 12: 308-313. PMID 21243718 DOI: 10.1002/Cbic.201000617  0.01
2011 Hausmann J, Kamtekar S, Christodoulou E, Day JE, Wu T, Fulkerson Z, Albers HM, van Meeteren LA, Houben AJ, van Zeijl L, Jansen S, Andries M, Hall T, Pegg LE, Benson TE, ... ... Ovaa H, et al. Structural basis of substrate discrimination and integrin binding by autotaxin. Nature Structural & Molecular Biology. 18: 198-204. PMID 21240271 DOI: 10.1038/Nsmb.1980  1
2010 El Oualid F, Merkx R, Ekkebus R, Hameed DS, Smit JJ, de Jong A, Hilkmann H, Sixma TK, Ovaa H. Chemical synthesis of ubiquitin, ubiquitin-based probes, and diubiquitin. Angewandte Chemie (International Ed. in English). 49: 10149-53. PMID 21117055 DOI: 10.1002/Anie.201005995  1
2010 Cavalli S, Houben AJ, Albers HM, van Tilburg EW, de Ru A, Aoki J, van Veelen P, Moolenaar WH, Ovaa H. Development of an activity-based probe for autotaxin. Chembiochem : a European Journal of Chemical Biology. 11: 2311-7. PMID 20941725 DOI: 10.1002/Cbic.201000349  1
2010 Hoppes R, Ekkebus R, Schumacher TNM, Ovaa H. Technologies for MHC class I immunoproteomics. Journal of Proteomics. 73: 1945-1953. PMID 20546957 DOI: 10.1016/J.Jprot.2010.05.009  1
2010 Shanmugham A, Fish A, Luna-Vargas MP, Faesen AC, El Oualid F, Sixma TK, Ovaa H. Nonhydrolyzable ubiquitin-isopeptide isosteres as deubiquitinating enzyme probes. Journal of the American Chemical Society. 132: 8834-5. PMID 20540574 DOI: 10.1021/Ja101803S  1
2010 Albers HM, van Meeteren LA, Egan DA, van Tilburg EW, Moolenaar WH, Ovaa H. Discovery and optimization of boronic acid based inhibitors of autotaxin. Journal of Medicinal Chemistry. 53: 4958-67. PMID 20536182 DOI: 10.1021/Jm1005012  1
2010 Pelletier S, Schuurman KG, Berkers CR, Ovaa H, Heck AJR, Raijmakers R. Quantifying cross-tissue diversity in proteasome complexes by mass spectrometry Molecular Biosystems. 6: 1450-1453. PMID 20498902 DOI: 10.1039/C004989A  1
2010 Albers HM, Dong A, van Meeteren LA, Egan DA, Sunkara M, van Tilburg EW, Schuurman K, van Tellingen O, Morris AJ, Smyth SS, Moolenaar WH, Ovaa H. Boronic acid-based inhibitor of autotaxin reveals rapid turnover of LPA in the circulation. Proceedings of the National Academy of Sciences of the United States of America. 107: 7257-62. PMID 20360563 DOI: 10.1073/Pnas.1001529107  1
2010 Berkers CR, Ovaa H. Drug discovery and assay development in the ubiquitin–proteasome system Biochemical Society Transactions. 38: 14-20. PMID 20074028 DOI: 10.1042/Bst0380014  1
2010 Verzijlbergen KF, Menendez-Benito V, van Welsem T, van Deventer SJ, Lindstrom DL, Ovaa H, Neefjes J, Gottschling DE, van Leeuwen F. Recombination-induced tag exchange to track old and new proteins. Proceedings of the National Academy of Sciences of the United States of America. 107: 64-8. PMID 20018668 DOI: 10.1073/Pnas.0911164107  1
2010 Duynstee HI, Ovaa H, Marel GAvd, Boom JHv. Synthesis of niruriside a HIV REV/RRE binding inhibitor Recueil Des Travaux Chimiques Des Pays-Bas. 115: 339-340. DOI: 10.1002/Recl.19961150607  1
2009 Hadrup SR, Toebes M, Rodenko B, Bakker AH, Egan DA, Ovaa H, Schumacher TN. High-throughput T-cell epitope discovery through MHC peptide exchange. Methods in Molecular Biology (Clifton, N.J.). 524: 383-405. PMID 19377960 DOI: 10.1007/978-1-59745-450-6_28  1
2009 Middeldorp J, Kamphuis W, Sluijs JA, Achoui D, Leenaars CH, Feenstra MG, van Tijn P, Fischer DF, Berkers C, Ovaa H, Quinlan RA, Hol EM. Intermediate filament transcription in astrocytes is repressed by proteasome inhibition. Faseb Journal : Official Publication of the Federation of American Societies For Experimental Biology. 23: 2710-26. PMID 19332645 DOI: 10.1096/Fj.08-127696  1
2009 Crawford LJ, Windrum P, Magill L, Melo JV, McCallum L, McMullin MF, Ovaa H, Walker B, Irvine AE. Proteasome proteolytic profile is linked to Bcr-Abl expression. Experimental Hematology. 37: 357-66. PMID 19157685 DOI: 10.1016/J.Exphem.2008.11.004  1
2009 Ovaa H, Kuijl C, Neefjes J. Recent and new targets for small molecule anti-cancer agents Drug Discovery Today: Technologies. 6: e3-e11. DOI: 10.1016/J.Ddtec.2010.01.001  1
2008 Kraus M, Malenke E, Gogel J, Müller H, Rückrich T, Overkleeft H, Ovaa H, Koscielniak E, Hartmann JT, Driessen C. Ritonavir induces endoplasmic reticulum stress and sensitizes sarcoma cells toward bortezomib-induced apoptosis. Molecular Cancer Therapeutics. 7: 1940-8. PMID 18645004 DOI: 10.1158/1535-7163.Mct-07-2375  1
2008 Raijmakers R, Berkers CR, de Jong A, Ovaa H, Heck AJ, Mohammed S. Automated online sequential isotope labeling for protein quantitation applied to proteasome tissue-specific diversity. Molecular & Cellular Proteomics : McP. 7: 1755-62. PMID 18534969 DOI: 10.1074/Mcp.M800093-Mcp200  1
2008 Birks EJ, Latif N, Enesa K, Folkvang T, Luong LA, Sarathchandra P, Khan M, Ovaa H, Terracciano CM, Barton PJR, Yacoub MH, Evans PC. Elevated p53 expression is associated with dysregulation of the ubiquitin-proteasome system in dilated cardiomyopathy Cardiovascular Research. 79: 472-480. PMID 18375498 DOI: 10.1093/Cvr/Cvn083  1
2008 Bakker AH, Hoppes R, Linnemann C, Toebes M, Rodenko B, Berkers CR, Hadrup SR, van Esch WJ, Heemskerk MH, Ovaa H, Schumacher TN. Conditional MHC class I ligands and peptide exchange technology for the human MHC gene products HLA-A1, -A3, -A11, and -B7. Proceedings of the National Academy of Sciences of the United States of America. 105: 3825-30. PMID 18308940 DOI: 10.1073/Pnas.0709717105  1
2008 Piva R, Ruggeri B, Williams M, Costa G, Tamagno I, Ferrero D, Giai V, Coscia M, Peola S, Massaia M, Pezzoni G, Allievi C, Pescalli N, Cassin M, di Giovine S, ... ... Ovaa H, et al. CEP-18770: A novel, orally active proteasome inhibitor with a tumor-selective pharmacologic profile competitive with bortezomib. Blood. 111: 2765-75. PMID 18057228 DOI: 10.1182/Blood-2007-07-100651  1
2008 Crawford L, Windrum P, Magill L, Melo JV, McCallum L, McMullin M, Ovaa H, Walker B, Irvine A. Bcr-Abl Positive Cells Display Increased Proteasome Activity and Greater Sensitivity to Proteasome Inhibition Blood. 112: 3192-3192. DOI: 10.1182/Blood.V112.11.3192.3192  1
2007 Butterworth MB, Edinger RS, Ovaa H, Burg D, Johnson JP, Frizzell RA. The deubiquitinating enzyme UCH-L3 regulates the apical membrane recycling of the epithelial sodium channel. The Journal of Biological Chemistry. 282: 37885-93. PMID 17967898 DOI: 10.1074/Jbc.M707989200  0.01
2007 Berkers CR, van Leeuwen FW, Groothuis TA, Peperzak V, van Tilburg EW, Borst J, Neefjes JJ, Ovaa H. Profiling proteasome activity in tissue with fluorescent probes. Molecular Pharmaceutics. 4: 739-48. PMID 17708652 DOI: 10.1021/Mp0700256  1
2007 Ovaa H. Active-site directed probes to report enzymatic action in the ubiquitin proteasome system Nature Reviews Cancer. 7: 613-620. PMID 17646866 DOI: 10.1038/Nrc2128  0.01
2007 Kristiansen M, Deriziotis P, Dimcheff DE, Jackson GS, Ovaa H, Naumann H, Clarke AR, van Leeuwen FW, Menéndez-Benito V, Dantuma NP, Portis JL, Collinge J, Tabrizi SJ. Disease-associated prion protein oligomers inhibit the 26S proteasome. Molecular Cell. 26: 175-88. PMID 17466621 DOI: 10.1016/J.Molcel.2007.04.001  1
2007 Ponnappan S, Ovaa H, Ponnappan U. Lower expression of catalytic and structural subunits of the proteasome contributes to decreased proteolysis in peripheral blood T lymphocytes during aging. The International Journal of Biochemistry & Cell Biology. 39: 799-809. PMID 17317272 DOI: 10.1016/J.Biocel.2007.01.002  0.01
2007 Kang SH, Kim GR, Seong M, Baek SH, Seol JH, Bang OS, Ovaa H, Tatsumi K, Komatsu M, Tanaka K, Chung CH. Two novel ubiquitin-fold modifier 1 (Ufm1)-specific proteases, UfSP1 and UfSP2. The Journal of Biological Chemistry. 282: 5256-62. PMID 17182609 DOI: 10.1074/Jbc.M610590200  0.01
2007 Kraus M, Rückrich T, Reich M, Gogel J, Beck A, Kammer W, Berkers CR, Burg D, Overkleeft H, Ovaa H, Driessen C. Activity patterns of proteasome subunits reflect bortezomib sensitivity of hematologic malignancies and are variable in primary human leukemia cells. Leukemia. 21: 84-92. PMID 17024115 DOI: 10.1038/Sj.Leu.2404414  1
2006 Rodenko B, Toebes M, Hadrup SR, Esch WJEv, Molenaar AM, Schumacher TNM, Ovaa H. Generation of peptide-MHC class I complexes through UV-mediated ligand exchange. Nature Protocols. 1: 1120-1132. PMID 17406393 DOI: 10.1038/Nprot.2006.121  1
2006 Verdoes M, Florea BI, Menendez-Benito V, Maynard CJ, Witte MD, van der Linden WA, van den Nieuwendijk AM, Hofmann T, Berkers CR, van Leeuwen FW, Groothuis TA, Leeuwenburgh MA, Ovaa H, Neefjes JJ, Filippov DV, et al. A fluorescent broad-spectrum proteasome inhibitor for labeling proteasomes in vitro and in vivo. Chemistry & Biology. 13: 1217-26. PMID 17114003 DOI: 10.1016/J.Chembiol.2006.09.013  1
2006 Hol EM, Fischer DF, Ovaa H, Scheper W. Ubiquitin proteasome system as a pharmacological target in neurodegeneration. Expert Review of Neurotherapeutics. 6: 1337-47. PMID 17009921 DOI: 10.1586/14737175.6.9.1337  1
2006 Verdoes M, Berkers CR, Florea BI, Swieten PFv, Overkleeft HS, Ovaa H. Chemical proteomics profiling of proteasome activity. Methods of Molecular Biology. 328: 51-69. PMID 16785641 DOI: 10.1385/1-59745-026-X:51  1
2006 Crawford LJA, Walker B, Ovaa H, Chauhan D, Anderson KC, Morris TCM, Irvine AE. Comparative selectivity and specificity of the proteasome inhibitors BzLLLCOCHO, PS-341, and MG-132. Cancer Research. 66: 6379-6386. PMID 16778216 DOI: 10.1158/0008-5472.Can-06-0605  1
2006 Groll M, Berkers CR, Ploegh HL, Ovaa H. Crystal structure of the boronic acid-based proteasome inhibitor bortezomib in complex with the yeast 20S proteasome Structure. 14: 451-456. PMID 16531229 DOI: 10.1016/J.Str.2005.11.019  1
2006 Toebes M, Coccoris M, Bins A, Rodenko B, Gomez R, Nieuwkoop NJ, Kasteele Wvd, Rimmelzwaan GF, Haanen JBAG, Ovaa H, Schumacher TNM. Design and use of conditional MHC class I ligands Nature Medicine. 12: 246-251. PMID 16462803 DOI: 10.1038/Nm1360  1
2006 Rolén U, Kobzeva V, Gasparjan N, Ovaa H, Winberg G, Kisseljov F, Masucci MG. Activity profiling of deubiquitinating enzymes in cervical carcinoma biopsies and cell lines. Molecular Carcinogenesis. 45: 260-269. PMID 16402389 DOI: 10.1002/Mc.20177  1
2006 Chauhan D, Singh A, Velankar M, Hideshima T, Ovaa H, Berkers C, Bianchi G, Sitia R, Munshi NC, Richardson P, Palladino MA, Anderson KC. Distinct Dynamic Profiles for NPI-0052-And Bortezomib-Induced Apoptosis in Multiple Myeloma. Blood. 108: 3396-3396. DOI: 10.1182/Blood.V108.11.3396.3396  1
2006 Risseeuw MDP, Berkers CR, Ploegh HL, Ovaa H. Synthesis of tritium labeled KRN7000 Tetrahedron Letters. 47: 3677-3679. DOI: 10.1016/J.Tetlet.2006.03.131  1
2005 Ovaa H, Galardy PJ, Ploegh HL. Mechanism-based proteomics tools based on ubiquitin and ubiquitin-like proteins: Synthesis of active site-directed probes Methods in Enzymology. 399: 468-478. PMID 16338376 DOI: 10.1016/S0076-6879(05)99032-0  1
2005 Galardy P, Ploegh HL, Ovaa H. Mechanism-based proteomics tools based on ubiquitin and ubiquitin-like proteins: Crystallography, activity profiling, and protease identification Methods in Enzymology. 399: 120-131. PMID 16338352 DOI: 10.1016/S0076-6879(05)99008-3  1
2005 Chauhan D, Catley L, Li G, Podar K, Hideshima T, Velankar M, Mitsiades C, Mitsiades N, Yasui H, Letai A, Ovaa H, Berkers C, Nicholson B, Chao TH, Neuteboom ST, et al. A novel orally active proteasome inhibitor induces apoptosis in multiple myeloma cells with mechanisms distinct from Bortezomib. Cancer Cell. 8: 407-19. PMID 16286248 DOI: 10.1016/J.Ccr.2005.10.013  1
2005 Tseng HC, Ovaa H, Wei NJ, Ploegh H, Tsai LH. Phosphoproteomic analysis with a solid-phase capture-release-tag approach. Chemistry & Biology. 12: 769-77. PMID 16039524 DOI: 10.1016/J.Chembiol.2005.05.012  0.01
2005 Meulmeester E, Maurice MM, Boutell C, Teunisse AFAS, Ovaa H, Abraham TE, Dirks RW, Jochemsen AG. Loss of HAUSP-mediated deubiquitination contributes to DNA damage-induced destabilization of Hdmx and Hdm2 Molecular Cell. 18: 565-576. PMID 15916963 DOI: 10.1016/J.Molcel.2005.04.024  1
2005 Berkers CR, Ovaa H. Immunotherapeutic potential for ceramide-based activators of iNKT cells Trends in Pharmacological Sciences. 26: 252-257. PMID 15860372 DOI: 10.1016/J.Tips.2005.03.005  1
2005 Berkers CR, Verdoes M, Lichtman E, Fiebiger E, Kessler BM, Anderson KC, Ploegh HL, Ovaa H, Galardy PJ. Activity probe for in vivo profiling of the specificity of proteasome inhibitor bortezomib Nature Methods. 2: 357-362. PMID 15846363 DOI: 10.1038/Nmeth759  1
2005 Borodovsky A, Ovaa H, Meester WJ, Venanzi ES, Bogyo MS, Hekking BG, Ploegh HL, Kessler BM, Overkleeft HS. Small-molecule inhibitors and probes for ubiquitin- and ubiquitin-like-specific proteases. Chembiochem : a European Journal of Chemical Biology. 6: 287-91. PMID 15651044 DOI: 10.1002/Cbic.200400236  1
2005 Misaghi S, Galardy PJ, Meester WJ, Ovaa H, Ploegh HL, Gaudet R. Structure of the ubiquitin hydrolase UCH-L3 complexed with a suicide substrate. The Journal of Biological Chemistry. 280: 1512-20. PMID 15531586 DOI: 10.1074/Jbc.M410770200  1
2005 Driessen C, Kraus M, Gogel J, Beck A, Kammer W, Ovaa H, Overkleeft H, Rückrich T. Activity Profiling of Proteasome Subunits and Deubiquitinating Enzymes in Human Hematopoetic Malignancies. Blood. 106: 617-617. DOI: 10.1182/Blood.V106.11.617.617  1
2005 Driessen C, Gogel J, Kraus M, Ovaa H, Beck A, Rückrich T. Acquired Bortezomib (Velcade®)-Resistance Is Accompanied by Downmodulation of Proteasome Activity and Upregulation of Tripeptidyl Peptidase II (TPPII) and a Ubiquitin-Specific Protease. Blood. 106: 3375-3375. DOI: 10.1182/Blood.V106.11.3375.3375  1
2005 Crawford LJA, Ovaa H, Walker B, Chauhan D, Anderson KC, Morris TCM, Irvine AE. Evaluation of the Specificity and Cytotoxicity of Three Proteasome Inhibitors. Blood. 106: 3366-3366. DOI: 10.1182/Blood.V106.11.3366.3366  1
2005 Chauhan D, Chao T, Catley L, Nicholson B, Velanker M, Hideshima T, Berkers C, Ovaa H, Neuteboom S, Palladino M, Anderson KC. In vitro and in vivo proteasome activity profiles of bortezomib and a novel proteasome inhibitor NPI-0052 Blood. 106: 3363-3363. DOI: 10.1182/Blood.V106.11.3363.3363  1
2004 Bogyo M, Baruch A, Jeffery DA, Greenbaum D, Borodovsky A, Ovaa H, Kessler B. Applications for chemical probes of proteolytic activity. Current Protocols in Protein Science / Editorial Board, John E. Coligan ... [Et Al.]. Unit 21.17. PMID 18429259 DOI: 10.1002/0471140864.Ps2117S36  1
2004 Hemelaar J, Galardy PJ, Borodovsky A, Kessler BM, Ploegh HL, Ovaa H. Chemistry-based functional proteomics: mechanism-based activity-profiling tools for ubiquitin and ubiquitin-like specific proteases. Journal of Proteome Research. 3: 268-76. PMID 15113103 DOI: 10.1021/Pr0341080  1
2004 Schmidt-Supprian M, Tian J, Grant EP, Pasparakis M, Maehr R, Ovaa H, Ploegh HL, Coyle AJ, Rajewsky K. Differential dependence of CD4+CD25+ regulatory and natural killer-like T cells on signals leading to NF-κB activation Proceedings of the National Academy of Sciences of the United States of America. 101: 4566-4571. PMID 15070758 DOI: 10.1073/Pnas.0400885101  1
2004 Ovaa H, Kessler BM, Rolén U, Galardy PJ, Ploegh HL, Masucci MG. Activity-based ubiquitin-specific protease (USP) profiling of virus-infected and malignant human cells. Proceedings of the National Academy of Sciences of the United States of America. 101: 2253-8. PMID 14982996 DOI: 10.1073/Pnas.0308411100  1
2004 Evans PC, Ovaa H, Hamon M, Kilshaw PJ, Hamm S, Bauer S, Ploegh HL, Smith TS. Zinc-finger protein A20, a regulator of inflammation and cell survival, has de-ubiquitinating activity. The Biochemical Journal. 378: 727-34. PMID 14748687 DOI: 10.1042/Bj20031377  1
2004 Hemelaar J, Borodovsky A, Kessler BM, Reverter D, Cook J, Kolli N, Gan-Erdene T, Wilkinson KD, Gill G, Lima CD, Ploegh HL, Ovaa H. Specific and covalent targeting of conjugating and deconjugating enzymes of ubiquitin-like proteins. Molecular and Cellular Biology. 24: 84-95. PMID 14673145 DOI: 10.1128/Mcb.24.1.84-95.2004  1
2003 Ovaa H, van Swieten PF, Kessler BM, Leeuwenburgh MA, Fiebiger E, van den Nieuwendijk AM, Galardy PJ, van der Marel GA, Ploegh HL, Overkleeft HS. Chemistry in living cells: detection of active proteasomes by a two-step labeling strategy. Angewandte Chemie (International Ed. in English). 42: 3626-9. PMID 12916032 DOI: 10.1002/Anie.200351314  1
2002 Borodovsky A, Ovaa H, Kolli N, Gan-Erdene T, Wilkinson KD, Ploegh HL, Kessler BM. Chemistry-based functional proteomics reveals novel members of the deubiquitinating enzyme family. Chemistry & Biology. 9: 1149-59. PMID 12401499 DOI: 10.1016/S1074-5521(02)00248-X  1
2002 Verhelst SHL, Wiedenhof W, Ovaa H, Van Der Marel GA, Overkleeft HS, Van Boeckel CAA, Van Boom JH. A stereoselective route towards highly functionalized 4,6-diaminocyclohexene derivatives Tetrahedron Letters. 43: 6451-6455. DOI: 10.1016/S0040-4039(02)01364-3  1
2001 Timmer MSM, Ovaa H, Filippov DV, Van Der Marel GA, Van Boom JH. Synthesis of phosphorus mono- and bicycles by catalytic ring-closing metathesis Tetrahedron Letters. 42: 8231-8233. DOI: 10.1016/S0040-4039(01)01740-3  1
2001 Ovaa H, Van der Marel GA, Van Boom JH. A convenient approach towards 2′-analogs of zoapatanol from D-glucose Tetrahedron Letters. 42: 5749-5752. DOI: 10.1016/S0040-4039(01)00932-7  1
2000 Ovaa H, Stragies R, Marel GAvd, Boom JHv, Blechert S. Asymmetric synthesis of indolizidine alkaloids by ring-closing–ring-opening metathesis Chemical Communications. 1501-1502. DOI: 10.1039/B004106H  1
2000 Timmer MSM, Ovaa H, Filippov DV, Marel GAvd, Boom JHv. An expeditious route to phosphorus heterocycles based on ring-closing metathesis Tetrahedron Letters. 41: 8635-8638. DOI: 10.1016/S0040-4039(00)01511-2  1
1999 Ovaa H, Codée JDC, Lastdrager B, Overkleeft HS, Van Der Marel GA, Van Boom JH. A versatile approach to the synthesis of highly functionalised carbocycles Tetrahedron Letters. 40: 5063-5066. DOI: 10.1016/S0040-4039(99)00911-9  1
1999 Duynstee HI, Koning MCd, Ovaa H, Marel GAvd, Boom JHv. Synthesis of Verbascoside: A Dihydroxyphenylethyl Glycoside with Diverse Bioactivity European Journal of Organic Chemistry. 1999: 2623-2632. DOI: 10.1002/(Sici)1099-0690(199910)1999:10<2623::Aid-Ejoc2623>3.0.Co;2-K  1
1998 Ovaa H, Codée JDC, Lastdrager B, Overkleeft HS, Van Der Marel GA, Van Boom JH. A stereoselective and efficient route to (3S, 4R, 5S)-(+)-4,5- dihydroxycyclopent-1-en-3-ylamine: The side chain of the hypermodified nucleoside Q Tetrahedron Letters. 39: 7987-7990. DOI: 10.1016/S0040-4039(98)01738-9  1
1998 Ovaa H, Leeuwenburgh MA, Overkleeft HS, Van Der Marel GA, Van Boom JH. An expeditious route to the synthesis of highly functionalized chiral oxepines from monosaccharides Tetrahedron Letters. 39: 3025-3028. DOI: 10.1016/S0040-4039(98)00324-4  1
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