John C. Chaput, Ph.D. - Publications

Affiliations: 
Arizona State University, Tempe, AZ, United States 
 Havard Medical School, Boston, MA, United States 
 University of California, Riverside, Riverside, CA, United States 
Website:
http://www.faculty.uci.edu/profile.cfm?faculty_id=6145

77 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any innacuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2019 McCloskey CM, Liao JY, Bala S, Chaput JC. Ligase-Mediated Threose Nucleic Acid Synthesis on DNA Templates. Acs Synthetic Biology. PMID 30629885 DOI: 10.1021/acssynbio.8b00511  0.32
2018 Wang Y, Ngor AK, Nikoomanzar A, Chaput JC. Evolution of a General RNA-Cleaving FANA Enzyme. Nature Communications. 9: 5067. PMID 30498223 DOI: 10.1038/s41467-018-07611-1  0.8
2018 Mehta AP, Wang Y, Reed SA, Supekova L, Javahishvili T, Chaput JC, Schultz PG. Bacterial Genome Containing Chimeric DNA-RNA Sequences. Journal of the American Chemical Society. PMID 30160955 DOI: 10.1021/jacs.8b07046  0.8
2018 Bala S, Liao JY, Zhang L, Tran CN, Chim N, Chaput JC. Synthesis of 2'-Deoxy-α-L-Threofuranosyl Nucleoside Triphosphates. The Journal of Organic Chemistry. PMID 30011988 DOI: 10.1021/acs.joc.8b00875  0.32
2018 Mei H, Liao JY, Jimenez RM, Wang Y, Bala S, McCloskey C, Switzer C, Chaput JC. Synthesis and Evolution of a TNA Aptamer Bearing 7-Deaza-7-Substituted Guanosine Residues. Journal of the American Chemical Society. PMID 29667819 DOI: 10.1021/jacs.7b13031  1
2018 Mei H, Chaput JC. Expanding the chemical diversity of TNA with tUTP derivatives that are substrates for a TNA polymerase. Chemical Communications (Cambridge, England). PMID 29340357 DOI: 10.1039/c7cc09130c  0.6
2018 Feldman AW, Fischer EC, Ledbetter MP, Liao JY, Chaput JC, Romesberg FE. A Tool for the Import of Natural and Unnatural Nucleoside Triphosphates into Bacteria. Journal of the American Chemical Society. PMID 29338214 DOI: 10.1021/jacs.7b11404  0.32
2017 Chim N, Shi C, Sau SP, Nikoomanzar A, Chaput JC. Structural basis for TNA synthesis by an engineered TNA polymerase. Nature Communications. 8: 1810. PMID 29180809 DOI: 10.1038/s41467-017-02014-0  0.8
2017 Nikoomanzar A, Dunn MR, Chaput JC. Evaluating the Rate and Substrate Specificity of Laboratory Evolved XNA Polymerases. Analytical Chemistry. PMID 29148714 DOI: 10.1021/acs.analchem.7b03807  0.8
2017 Nikoomanzar A, Dunn MR, Chaput JC. Engineered Polymerases with Altered Substrate Specificity: Expression and Purification. Current Protocols in Nucleic Acid Chemistry. 69: 4.75.1-4.75.20. PMID 28628207 DOI: 10.1002/cpnc.33  0.8
2017 Bala S, Liao JY, Mei H, Chaput JC. Synthesis of α-L-Threofuranosyl Nucleoside 3'-Monophosphates, 3'-Phosphoro(2-Methyl)imidazolides, and 3'-Triphosphates. The Journal of Organic Chemistry. PMID 28490177 DOI: 10.1021/acs.joc.7b00892  0.6
2017 Mei H, Shi C, Jimenez RM, Wang Y, Kardouh M, Chaput JC. Synthesis and polymerase activity of a fluorescent cytidine TNA triphosphate analogue. Nucleic Acids Research. PMID 28472363 DOI: 10.1093/nar/gkx368  0.8
2016 Liao JY, Anosova I, Bala S, Van Horn WD, Chaput JC. A Parallel Stranded G-Quadruplex Composed of Threose Nucleic Acid (TNA). Biopolymers. PMID 27718227 DOI: 10.1002/bip.22999  0.32
2016 Dunn MR, Chaput JC. Reverse Transcription of Threose Nucleic Acid by a Naturally Occurring DNA Polymerase. Chembiochem : a European Journal of Chemical Biology. PMID 27383648 DOI: 10.1002/cbic.201600338  0.36
2016 Anosova I, Kowal EA, Sisco NJ, Sau S, Liao JY, Bala S, Rozners E, Egli M, Chaput JC, Van Horn WD. Structural Insights into Conformational Differences between DNA/TNA and RNA/TNA Chimeric Duplexes. Chembiochem : a European Journal of Chemical Biology. PMID 27347671 DOI: 10.1002/cbic.201600349  1
2016 Sau SP, Chaput JC. A one-pot synthesis of α-l-threofuranosyl nucleoside triphosphates (tNTPs). Bioorganic & Medicinal Chemistry Letters. PMID 27246616 DOI: 10.1016/j.bmcl.2016.05.057  1
2016 Culbertson MC, Temburnikar KW, Sau SP, Liao JY, Bala S, Chaput JC. Evaluating TNA stability under simulated physiological conditions. Bioorganic & Medicinal Chemistry Letters. PMID 27080186 DOI: 10.1016/j.bmcl.2016.03.118  1
2016 Larsen AC, Dunn MR, Hatch A, Sau SP, Youngbull C, Chaput JC. A general strategy for expanding polymerase function by droplet microfluidics. Nature Communications. 7: 11235. PMID 27044725 DOI: 10.1038/ncomms11235  1
2016 Sau SP, Fahmi NE, Liao JY, Bala S, Chaput JC. A Scalable Synthesis of alpha-L-Threose Nucleic Acid Monomers. The Journal of Organic Chemistry. PMID 26895480 DOI: 10.1021/acs.joc.5b02768  1
2016 Dunn MR, Otto C, Fenton KE, Chaput JC. Improving Polymerase Activity with Unnatural Substrates by Sampling Mutations in Homologous Protein Architectures. Acs Chemical Biology. PMID 26860781 DOI: 10.1021/acschembio.5b00949  0.36
2015 Anosova I, Kowal EA, Dunn MR, Chaput JC, Van Horn WD, Egli M. The structural diversity of artificial genetic polymers. Nucleic Acids Research. PMID 26673703 DOI: 10.1093/nar/gkv1472  1
2015 Dunn MR, Larsen AC, Zahurancik WJ, Fahmi NE, Meyers M, Suo Z, Chaput JC. DNA polymerase-mediated synthesis of unbiased threose nucleic acid (TNA) polymers requires 7-deazaguanine to suppress G:G mispairing during TNA transcription. Journal of the American Chemical Society. 137: 4014-7. PMID 25785966 DOI: 10.1021/ja511481n  1
2014 Hartsough EM, Shah P, Larsen AC, Chaput JC. Comparative analysis of eukaryotic cell-free expression systems. Biotechniques. 59: 149-51. PMID 26345507 DOI: 10.2144/000114327  1
2014 Sau SP, Larsen AC, Chaput JC. Automated solid-phase synthesis of high capacity oligo-dT cellulose for affinity purification of poly-A tagged biomolecules. Bioorganic & Medicinal Chemistry Letters. 24: 5692-4. PMID 25467163 DOI: 10.1016/j.bmcl.2014.10.065  1
2014 Chaput JC. Replicating an expanded genetic alphabet in cells Chembiochem : a European Journal of Chemical Biology. 15: 1869-1871. PMID 25044483 DOI: 10.1002/cbic.201402289  1
2014 Larsen AC, Gillig A, Shah P, Sau SP, Fenton KE, Chaput JC. General approach for characterizing in vitro selected peptides with protein binding affinity. Analytical Chemistry. 86: 7219-23. PMID 24970615 DOI: 10.1021/ac501614d  1
2014 Dunn MR, Chaput JC. An In Vitro Selection Protocol for Threose Nucleic Acid (TNA) Using DNA Display. Current Protocols in Nucleic Acid Chemistry / Edited by Serge L. Beaucage ... [Et Al.]. 57: 9.8.1-9.8.19. PMID 24961723 DOI: 10.1002/0471142700.nc0908s57  1
2014 Saul J, Petritis B, Sau S, Rauf F, Gaskin M, Ober-Reynolds B, Mineyev I, Magee M, Chaput J, Qiu J, LaBaer J. Development of a full-length human protein production pipeline. Protein Science : a Publication of the Protein Society. 23: 1123-35. PMID 24806540 DOI: 10.1002/pro.2484  1
2013 Wellensiek BP, Larsen AC, Flores J, Jacobs BL, Chaput JC. A leader sequence capable of enhancing RNA expression and protein synthesis in mammalian cells. Protein Science : a Publication of the Protein Society. 22: 1392-8. PMID 23908110 DOI: 10.1002/pro.2325  1
2013 Wellensiek BP, Larsen AC, Stephens B, Kukurba K, Waern K, Briones N, Liu L, Snyder M, Jacobs BL, Kumar S, Chaput JC. Genome-wide profiling of human cap-independent translation-enhancing elements. Nature Methods. 10: 747-50. PMID 23770754 DOI: 10.1038/nmeth.2522  1
2013 Zhang S, Yu H, Chaput JC. Synthesis of threose nucleic acid (TNA) triphosphates and oligonucleotides by polymerase-mediated primer extension. Current Protocols in Nucleic Acid Chemistry / Edited by Serge L. Beaucage ... [Et Al.]. Unit 4.54. PMID 23512696 DOI: 10.1002/0471142700.nc0454s52  1
2013 Yu H, Zhang S, Dunn MR, Chaput JC. An efficient and faithful in vitro replication system for threose nucleic acid Journal of the American Chemical Society. 135: 3583-3591. PMID 23432469 DOI: 10.1021/ja3118703  1
2013 Zhang S, Chaput JC. Synthesis and enzymatic incorporation of α-l-threofuranosyl adenine triphosphate (tATP) Bioorganic and Medicinal Chemistry Letters. 23: 1447-1449. PMID 23352269 DOI: 10.1016/j.bmcl.2012.12.080  1
2013 Korch SB, Stomel JM, León MA, Hamada MA, Stevenson CR, Simpson BW, Gujulla SK, Chaput JC. ATP sequestration by a synthetic ATP-binding protein leads to novel phenotypic changes in Escherichia coli. Acs Chemical Biology. 8: 451-63. PMID 23181457 DOI: 10.1021/cb3004786  1
2013 Zhang S, Yu H, Chaput JC. Synthesis of threose nucleic acid (TNA) triphosphates and oligonucleotides by polymerase-mediated primer extension Current Protocols in Nucleic Acid Chemistry. DOI: 10.1002/0471142700.nc0454s52  1
2012 Chaput JC, Yu H, Zhang S. The emerging world of synthetic genetics Chemistry and Biology. 19: 1360-1371. PMID 23177191 DOI: 10.1016/j.chembiol.2012.10.011  1
2012 Zhang S, Chaput JC. Synthesis of threose Nucleic Acid (TNA) phosphoramidite monomers and oligonucleotide polymers Current Protocols in Nucleic Acid Chemistry. PMID 22956457 DOI: 10.1002/0471142700.nc0451s50  1
2012 Kang M, Heuberger B, Chaput JC, Switzer C, Feigon J. Solution structure of a parallel-stranded oligoisoguanine DNA pentaplex formed by d(T(iG)4T) in the presence of Cs+ ions Angewandte Chemie - International Edition. 51: 7952-7955. PMID 22767484 DOI: 10.1002/anie.201203459  1
2012 Pinheiro VB, Taylor AI, Cozens C, Abramov M, Renders M, Zhang S, Chaput JC, Wengel J, Peak-Chew SY, McLaughlin SH, Herdewijn P, Holliger P. Synthetic genetic polymers capable of heredity and evolution. Science (New York, N.Y.). 336: 341-4. PMID 22517858 DOI: 10.1126/science.1217622  1
2012 Yu H, Zhang S, Chaput JC. Darwinian evolution of an alternative genetic system provides support for TNA as an RNA progenitor Nature Chemistry. 4: 183-187. PMID 22354431 DOI: 10.1038/nchem.1241  1
2011 Yu H, Jiang B, Chaput JC. Aptamers can discriminate alkaline proteins with high specificity Chembiochem. 12: 2659-2666. PMID 22021204 DOI: 10.1002/cbic.201100252  1
2011 Liu R, Jiang B, Yu H, Chaput JC. Generating DNA Synbodies from Previously Discovered Peptides Chembiochem. 12: 1813-1817. PMID 21692159 DOI: 10.1002/cbic.201100284  1
2010 Zhang J, Williams BA, Nilsson MT, Chaput JC. The evolvability of lead peptides from small library screens. Chemical Communications (Cambridge, England). 46: 7778-80. PMID 20830334 DOI: 10.1039/c0cc01475c  1
2010 Williams BA, Chaput JC. Synthesis of peptide-oligonucleotide conjugates using a heterobifunctional crosslinker. Current Protocols in Nucleic Acid Chemistry / Edited by Serge L. Beaucage ... [Et Al.]. Unit4.41. PMID 20827717 DOI: 10.1002/0471142700.nc0441s42  1
2010 Zhang S, Chaput JC. Synthesis of glycerol nucleic acid (GNA) phosphoramidite monomers and oligonucleotide polymers Current Protocols in Nucleic Acid Chemistry. 4.40.1-4.40.18. PMID 20827716 DOI: 10.1002/0471142700.nc0440s42  1
2010 Simmons CR, Magee CL, Smith DA, Lauman L, Chaput JC, Allen JP. Three-dimensional structures reveal multiple ADP/ATP binding modes for a synthetic class of artificial proteins. Biochemistry. 49: 8689-99. PMID 20822107 DOI: 10.1021/bi100398p  1
2010 McCullum EO, Williams BA, Zhang J, Chaput JC. Random mutagenesis by error-prone PCR. Methods in Molecular Biology (Clifton, N.J.). 634: 103-9. PMID 20676978 DOI: 10.1007/978-1-60761-652-8_7  1
2010 Zhang S, Switzer C, Chaput JC. The resurgence of acyclic nucleic acids Chemistry and Biodiversity. 7: 245-258. PMID 20151377 DOI: 10.1002/cbdv.200900281  1
2009 Williams BA, Diehnelt CW, Belcher P, Greving M, Woodbury NW, Johnston SA, Chaput JC. Creating protein affinity reagents by combining peptide ligands on synthetic DNA scaffolds. Journal of the American Chemical Society. 131: 17233-41. PMID 19894711 DOI: 10.1021/ja9051735  1
2009 Stomel JM, Wilson JW, Léon MA, Stafford P, Chaput JC. A man-made ATP-binding protein evolved independent of nature causes abnormal growth in bacterial cells Plos One. 4. PMID 19812699 DOI: 10.1371/journal.pone.0007385  1
2009 Stearns LA, Chhabra R, Sharma J, Liu Y, Petuskey WT, Yan H, Chaput JC. Template-directed nucleation and growth of inorganic nanoparticles on DNA scaffolds. Angewandte Chemie (International Ed. in English). 48: 8494-6. PMID 19795428 DOI: 10.1002/anie.200903319  1
2009 Lin L, Fu Q, Williams BA, Azzaz AM, Shogren-Knaak MA, Chaput JC, Lindsay S. Recognition imaging of acetylated chromatin using a DNA aptamer. Biophysical Journal. 97: 1804-7. PMID 19751687 DOI: 10.1016/j.bpj.2009.06.045  1
2009 Lin S, Horning DP, Szostak JW, Chaput JC. Conformational analysis of DNA repair intermediates by time-resolved fluorescence spectroscopy Journal of Physical Chemistry A. 113: 9585-9587. PMID 19673467 DOI: 10.1021/jp906746w  1
2009 Simmons CR, Stomel JM, McConnell MD, Smith DA, Watkins JL, Allen JP, Chaput JC. A synthetic protein selected for ligand binding affinity mediates ATP hydrolysis. Acs Chemical Biology. 4: 649-58. PMID 19522480 DOI: 10.1021/cb900109w  1
2009 McCullum EO, Chaput JC. Transcription of an RNA aptamer by a DNA polymerase Chemical Communications. 2938-2940. PMID 19436916 DOI: 10.1039/b820678c  1
2009 Williams BA, Lin L, Lindsay SM, Chaput JC. Evolution of a histone H4-K16 acetyl-specific DNA aptamer. Journal of the American Chemical Society. 131: 6330-1. PMID 19385619 DOI: 10.1021/ja900916p  1
2009 Stearns LA, Chhabra R, Petuskey WT, Yan H, Chaput JC. Template-directed synthesis of self-assembled inorganic nanostructures Extended Abstracts For 6th Annual Conference On Foundations of Nanoscience: Self-Assembled Architectures and Devices, Fnano 2009. 89-92.  1
2008 Chaput JC, Woodbury NW, Stearns LA, Williams BA. Creating protein biocatalysts as tools for future industrial applications. Expert Opinion On Biological Therapy. 8: 1087-98. PMID 18613761 DOI: 10.1517/14712598.8.8.1087  1
2008 Watkins JL, Chaput JC. Searching combinatorial libraries for native proteins with novel folds Chembiochem. 9: 1361-1363. PMID 18464233 DOI: 10.1002/cbic.200800147  1
2008 Zhang RS, McCullum EO, Chaput JC. Synthesis of two mirror image 4-helix junctions derived from glycerol nucleic acid. Journal of the American Chemical Society. 130: 5846-7. PMID 18407636 DOI: 10.1021/ja800079j  1
2007 Lin L, Hom D, Lindsay SM, Chaput JC. In vitro selection of histone H4 aptamers for recognition imaging microscopy. Journal of the American Chemical Society. 129: 14568-9. PMID 17985909 DOI: 10.1021/ja076488m  1
2007 Yang YW, Zhang S, McCullum EO, Chaput JC. Experimental evidence that GNA and TNA were not sequential polymers in the prebiotic evolution of RNA. Journal of Molecular Evolution. 65: 289-95. PMID 17828568 DOI: 10.1007/s00239-007-9017-9  1
2007 Mansy SS, Zhang J, Kümmerle R, Nilsson M, Chou JJ, Szostak JW, Chaput JC. Structure and evolutionary analysis of a non-biological ATP-binding protein. Journal of Molecular Biology. 371: 501-13. PMID 17583732 DOI: 10.1016/j.jmb.2007.05.062  1
2007 Smith MD, Rosenow MA, Wang M, Allen JP, Szostak JW, Chaput JC. Structural insights into the evolution of a non-biological protein: Importance of surface residues in protein fold optimization Plos One. 2. PMID 17520026 DOI: 10.1371/journal.pone.0000467  1
2007 Williams BA, Lund K, Liu Y, Yan H, Chaput JC. Self-assembled peptide nanoarrays: an approach to studying protein-protein interactions. Angewandte Chemie (International Ed. in English). 46: 3051-4. PMID 17361972 DOI: 10.1002/anie.200603919  1
2005 Horhota A, Zou K, Ichida JK, Yu B, McLaughlin LW, Szostak JW, Chaput JC. Kinetic analysis of an efficient DNA-dependent TNA polymerase. Journal of the American Chemical Society. 127: 7427-34. PMID 15898792 DOI: 10.1021/ja0428255  1
2004 Chaput JC, Szostak JW. Evolutionary optimization of a nonbiological ATP binding protein for improved folding stability Chemistry and Biology. 11: 865-874. PMID 15217619 DOI: 10.1016/j.chembiol.2004.04.006  1
2003 Chaput JC, Szostak JW. TNA synthesis by DNA polymerases Journal of the American Chemical Society. 125: 9274-9275. PMID 12889939 DOI: 10.1021/ja035917n  1
2003 Chaput JC, Ichida JK, Szostak JW. DNA polymerase-mediated DNA synthesis on a TNA template. Journal of the American Chemical Society. 125: 856-7. PMID 12537469 DOI: 10.1021/ja028589k  1
2002 Chaput JC, Sinha S, Switzer C. 5-propynyluracil.diaminopurine: an efficient base-pair for non-enzymatic transcription of DNA. Chemical Communications (Cambridge, England). 1568-9. PMID 12170785  1
2002 Chaput JC, Sinha S, Switzer C. 5-propynyluracil·diaminopurine: An efficient base-pair for non-enzymatic transcription of DNA Chemical Communications. 1568-1569.  1
2001 Switzer C, Chaput JC. Probing structure and function with alternative nucleic acids bearing 2′,5′-linked, zwitterionic, and isocytosine·isoguanine components Methods. 23: 141-148. PMID 11181033 DOI: 10.1006/meth.2000.1115  1
2000 Chaput JC, Switzer C. Nonenzymatic oligomerization on templates containing phosphodiester-linked acyclic glycerol nucleic acid analogues Journal of Molecular Evolution. 51: 464-470. PMID 11080369  1
2000 Rice KP, Chaput JC, Cox MM, Switzer C. RecA protein promotes strand exchange with DNA substrates containing isoguanine and 5-methyl isocytosine Biochemistry. 39: 10177-10188. PMID 10956007 DOI: 10.1021/bi0003339  1
2000 Chaput JC, Switzer C. Non-enzymatic transcription of an isoG·isoC base pair [2] Journal of the American Chemical Society. 122: 12866-12867. DOI: 10.1021/ja002260m  1
1999 Chaput JC, Switzer C. A DNA pentaplex incorporating nucleobase quintets Proceedings of the National Academy of Sciences of the United States of America. 96: 10614-10619. PMID 10485874 DOI: 10.1073/pnas.96.19.10614  1
1997 Roberts C, Chaput JC, Switzer C. Beyond guanine quartets: Cation-induced formation of homogenous and chimeric DNA tetraplexes incorporating iso-guanine and guanine Chemistry and Biology. 4: 899-908. PMID 9427655  1
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