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Stephen B. Baylin - Publications

Affiliations: 
Johns Hopkins University, Baltimore, MD 
Area:
Cell Biology, Molecular Biology, Oncology
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399 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2024 Noë M, Mathios D, Annapragada AV, Koul S, Foda ZH, Medina JE, Cristiano S, Cherry C, Bruhm DC, Niknafs N, Adleff V, Ferreira L, Easwaran H, Baylin S, Phallen J, et al. DNA methylation and gene expression as determinants of genome-wide cell-free DNA fragmentation. Nature Communications. 15: 6690. PMID 39107309 DOI: 10.1038/s41467-024-50850-8  0.476
2024 Chomiak AA, Tiedemann RL, Liu Y, Kong X, Cui Y, Wiseman AK, Thurlow KE, Cornett EM, Topper MJ, Baylin SB, Rothbart SB. Select EZH2 inhibitors enhance viral mimicry effects of DNMT inhibition through a mechanism involving NFAT:AP-1 signaling. Science Advances. 10: eadk4423. PMID 38536911 DOI: 10.1126/sciadv.adk4423  0.373
2024 Tiedemann RL, Hrit J, Du Q, Wiseman AK, Eden HE, Dickson BM, Kong X, Chomiak AA, Vaughan RM, Hebert JM, David Y, Zhou W, Baylin SB, Jones PA, Clark SJ, et al. UHRF1 ubiquitin ligase activity supports the maintenance of low-density CpG methylation. Biorxiv : the Preprint Server For Biology. PMID 38405904 DOI: 10.1101/2024.02.13.580169  0.43
2024 Yang L, Tu L, Bisht S, Mao Y, Petkovich D, Thursby SJ, Liang J, Patel N, Yen RC, Largent T, Zahnow C, Brock M, Gabrielson K, Salimian KJ, Baylin SB, et al. Tissue-location-specific transcription programs drive tumor dependencies in colon cancer. Nature Communications. 15: 1384. PMID 38360902 DOI: 10.1038/s41467-024-45605-4  0.358
2023 Bhandari YR, Krishna V, Powers R, Parmar S, Thursby SJ, Gupta E, Kulak O, Gokare P, Reumers J, Van Wesenbeeck L, Bachman KE, Baylin SB, Easwaran H. Transcription factor expression repertoire basis for epigenetic and transcriptional subtypes of colorectal cancers. Proceedings of the National Academy of Sciences of the United States of America. 120: e2301536120. PMID 37487069 DOI: 10.1073/pnas.2301536120  0.751
2023 Kanholm T, Rentia U, Hadley M, Karlow JA, Cox OL, Diab N, Bendall ML, Dawson T, McDonald JI, Xie W, Crandall KA, Burns KH, Baylin SB, Easwaran H, Chiappinelli KB. Oncogenic Transformation Drives DNA Methylation Loss and Transcriptional Activation of Transposable Element Loci. Cancer Research. PMID 37249603 DOI: 10.1158/0008-5472.CAN-22-3485  0.357
2022 Pandey S, Djibo R, Darracq A, Calendo G, Zhang H, Henry RA, Andrews AJ, Baylin SB, Madzo J, Najmanovich R, Issa JJ, Raynal NJ. Selective CDK9 Inhibition by Natural Compound Toyocamycin in Cancer Cells. Cancers. 14. PMID 35884401 DOI: 10.3390/cancers14143340  0.399
2021 Pappalardi MB, Keenan K, Cockerill M, Kellner WA, Stowell A, Sherk C, Wong K, Pathuri S, Briand J, Steidel M, Chapman P, Groy A, Wiseman AK, McHugh CF, Campobasso N, ... ... Baylin SB, et al. Discovery of a first-in-class reversible DNMT1-selective inhibitor with improved tolerability and efficacy in acute myeloid leukemia. Nature Cancer. 2: 1002-1017. PMID 34790902  0.436
2021 McDonald JI, Diab N, Arthofer E, Hadley M, Kanholm T, Rentia U, Gomez S, Yu A, Grundy EE, Cox O, Topper MJ, Xing X, Strissel PL, Strick R, Wang T, ... Baylin SB, et al. Epigenetic therapies in ovarian cancer alter repetitive element expression in a TP53-dependent manner. Cancer Research. PMID 34433584 DOI: 10.1158/0008-5472.CAN-20-4243  0.361
2020 Siebenkäs C, Chiappinelli KB, Guzzetta AA, Sharma A, Jeschke J, Vatapalli R, Baylin SB, Ahuja N. Correction: Inhibiting DNA methylation activates cancer testis antigens and expression of the antigen processing and presentation machinery in colon and ovarian cancer cells. Plos One. 15: e0243944. PMID 33301506 DOI: 10.1371/journal.pone.0243944  0.361
2020 McLaughlin LJ, Stojanovic L, Kogan AA, Rutherford JL, Choi EY, Yen RC, Xia L, Zou Y, Lapidus RG, Baylin SB, Topper MJ, Rassool FV. Pharmacologic induction of innate immune signaling directly drives homologous recombination deficiency. Proceedings of the National Academy of Sciences of the United States of America. PMID 32651270 DOI: 10.1073/Pnas.2003499117  0.458
2020 Rothbart SB, Baylin SB. Epigenetic Therapy for Epithelioid Sarcoma. Cell. 181: 211. PMID 32302562 DOI: 10.1016/J.Cell.2020.03.042  0.383
2020 Lu Z, Zou J, Li S, Topper MJ, Tao Y, Zhang H, Jiao X, Xie W, Kong X, Vaz M, Li H, Cai Y, Xia L, Huang P, Rodgers K, ... ... Baylin SB, et al. Epigenetic therapy inhibits metastases by disrupting premetastatic niches. Nature. PMID 32103175 DOI: 10.1038/S41586-020-2054-X  0.418
2020 McLaughlin LJ, Kogan AA, Baylin SB, Topper MJ, Rassool FV. Abstract 969: Pharmacologic induction of innate immune signaling via STING directly drives homologous recombination deficiency Immunology. 80: 969-969. DOI: 10.1158/1538-7445.Am2020-969  0.468
2020 Tiedemann RL, Du Q, Dickson BM, Kong X, Chomiak AA, Zhou W, Johnson BK, Baylin SB, Jones PA, Clark SJ, Rothbart SB. High‐resolution Epigenome Mapping Reveals Distinct and Divergent Roles for UHRF1 in the Maintenance of DNA Methylation The Faseb Journal. 34: 1-1. DOI: 10.1096/Fasebj.2020.34.S1.05966  0.431
2019 Abbotts R, Topper MJ, Biondi C, Fontaine D, Goswami R, Stojanovic L, Choi EY, McLaughlin L, Kogan AA, Xia L, Lapidus R, Mahmood J, Baylin SB, Rassool FV. DNA methyltransferase inhibitors induce a BRCAness phenotype that sensitizes NSCLC to PARP inhibitor and ionizing radiation. Proceedings of the National Academy of Sciences of the United States of America. PMID 31591209 DOI: 10.1073/Pnas.1903765116  0.465
2019 Topper MJ, Vaz M, Marrone KA, Brahmer JR, Baylin SB. The emerging role of epigenetic therapeutics in immuno-oncology. Nature Reviews. Clinical Oncology. PMID 31548600 DOI: 10.1038/S41571-019-0266-5  0.388
2019 Travers M, Brown SM, Dunworth M, Holbert CE, Wiehagen KR, Bachman KE, Foley JR, Stone ML, Baylin SB, Casero RA, Zahnow CA. DFMO and 5-azacytidine increase M1 macrophages in the tumor microenvironment of murine ovarian cancer. Cancer Research. PMID 31088836 DOI: 10.1158/0008-5472.Can-18-4018  0.676
2019 Kong X, Chen J, Xie W, Brown SM, Cai Y, Wu K, Fan D, Nie Y, Yegnasubramanian S, Tiedemann RL, Tao Y, Chiu Yen RW, Topper MJ, Zahnow CA, Easwaran H, ... ... Baylin SB, et al. Defining UHRF1 Domains that Support Maintenance of Human Colon Cancer DNA Methylation and Oncogenic Properties. Cancer Cell. PMID 30956060 DOI: 10.1016/J.Ccell.2019.03.003  0.549
2019 Xie W, Baylin SB, Easwaran H. DNA methylation in senescence, aging and cancer. Oncoscience. 6: 291-293. PMID 30800716 DOI: 10.18632/oncoscience.476  0.391
2019 Tao Y, Kang B, Petkovich DA, Bhandari YR, In J, Stein-O'Brien G, Kong X, Xie W, Zachos N, Maegawa S, Vaidya H, Brown S, Chiu Yen RW, Shao X, Thakor J, ... ... Baylin SB, et al. Aging-like Spontaneous Epigenetic Silencing Facilitates Wnt Activation, Stemness, and Braf-Induced Tumorigenesis. Cancer Cell. 35: 315-328.e6. PMID 30753828 DOI: 10.1016/J.Ccell.2019.01.005  0.476
2019 Kogan AA, Mclaughlin LJ, Baer MR, Baylin S, Topper M, Rassool FV. DNA Methyltransferase Inhibitors Promote Homologous Recombination Deficiency through Induction of Immune Signaling, Sensitizing Acute Myeloid Leukemia Cells to PARP Inhibitors Blood. 134: 3763-3763. DOI: 10.1182/Blood-2019-129535  0.37
2019 Kong X, Chen J, Xie W, Brown SM, Cai Y, Wu K, Fan D, Nie Y, Tao Y, Yen RC, Easwaran H, Topper MJ, Rothbart SB, Xia L, Baylin SB. Abstract 947: Defining UHRF1 domains that support maintenance of human colon cancer DNA methylation and tumorigenicity Cancer Research. DOI: 10.1158/1538-7445.Sabcs18-947  0.488
2019 McLaughlin LJ, Kogan AA, Choi EY, Lapidus RS, Zou Y, Li H, Baylin SB, Topper MJ, Rassool FV. Abstract 4473: DNMT and PARP inhibitor combination therapy induces an interferon-driven homologous recombination defect in triple-negative breast cancers and acute myeloid leukemia Cancer Research. 79: 4473-4473. DOI: 10.1158/1538-7445.Am2019-4473  0.496
2018 Papp E, Hallberg D, Konecny GE, Bruhm DC, Adleff V, Noë M, Kagiampakis I, Palsgrove D, Conklin D, Kinose Y, White JR, Press MF, Drapkin R, Easwaran H, Baylin SB, et al. Integrated Genomic, Epigenomic, and Expression Analyses of Ovarian Cancer Cell Lines. Cell Reports. 25: 2617-2633. PMID 30485824 DOI: 10.1016/J.Celrep.2018.10.096  0.416
2018 Zhang H, Pandey S, Travers M, Sun H, Morton G, Madzo J, Chung W, Khowsathit J, Perez-Leal O, Barrero CA, Merali C, Okamoto Y, Sato T, Pan J, Garriga J, ... ... Baylin SB, et al. Targeting CDK9 Reactivates Epigenetically Silenced Genes in Cancer. Cell. 175: 1244-1258.e26. PMID 30454645 DOI: 10.1016/J.Cell.2018.09.051  0.514
2018 Liu M, Thomas SL, DeWitt AK, Zhou W, Madaj ZB, Ohtani H, Baylin SB, Liang G, Jones PA. Dual inhibition of DNA and histone methyltransferases increases viral mimicry in ovarian cancer cells. Cancer Research. PMID 30185548 DOI: 10.1158/0008-5472.Can-17-3953  0.499
2018 Stone ML, Chiappinelli KB, Li H, Murphy LM, Travers ME, Topper MJ, Mathios D, Lim M, Shih IM, Wang TL, Hung CF, Bhargava V, Wiehagen KR, Cowley GS, Bachman KE, ... ... Baylin SB, et al. Reply to Haffner et al.: DNA hypomethylation renders tumors more immunogenic. Proceedings of the National Academy of Sciences of the United States of America. PMID 30181297 DOI: 10.1073/Pnas.1811015115  0.736
2018 Lee V, Wang JS, Zahurak ML, Gootjes EC, Verheul HMW, Parkinson RM, Kerner Z, Sharma A, Rosner GL, De Jesus-Acosta A, Laheru DA, Le DT, Oganesian A, Lilly-Foreman E, Brown T, ... ... Baylin SB, et al. A phase I trial of a guadecitabine (SGI-110) and irinotecan in metastatic colorectal cancer patients previously exposed to irinotecan. Clinical Cancer Research : An Official Journal of the American Association For Cancer Research. PMID 30097434 DOI: 10.1158/1078-0432.Ccr-18-0421  0.374
2018 Pulliam N, Fang F, Ozes AR, Tang J, Adewuyi A, Keer HN, Lyons JF, Baylin SB, Matei D, Nakshatri H, Rassool FV, Miller KD, Nephew KP. An Effective Epigenetic-PARP inhibitor Combination Therapy for Breast and Ovarian Cancers Independent of BRCA-mutations. Clinical Cancer Research : An Official Journal of the American Association For Cancer Research. PMID 29615458 DOI: 10.1158/1078-0432.Ccr-18-0204  0.378
2018 Xie W, Kagiampakis I, Pan L, Zhang YW, Murphy L, Tao Y, Kong X, Kang B, Xia L, Carvalho FLF, Sen S, Chiu Yen RW, Zahnow CA, Ahuja N, Baylin SB, et al. DNA Methylation Patterns Separate Senescence from Transformation Potential and Indicate Cancer Risk. Cancer Cell. 33: 309-321.e5. PMID 29438699 DOI: 10.1016/J.Ccell.2018.01.008  0.533
2018 Ye F, Kong X, Zhang H, Liu Y, Shao Z, Jin J, Cai Y, Zhang R, Li L, Zhang YW, Liu YC, Zhang C, Xie W, Yu K, Ding H, ... ... Baylin SB, et al. Biochemical Studies and Molecular Dynamic Simulations Reveal the Molecular Basis of Conformational Changes in DNA methyltransferase-1 (DNMT1). Acs Chemical Biology. PMID 29381856 DOI: 10.1021/Acschembio.7B00890  0.371
2018 Szczepny A, Carey K, McKenzie L, Jayasekara WSN, Rossello F, Gonzalez-Rajal A, McCaw AS, Popovski D, Wang D, Sadler AJ, Mahar A, Russell PA, Wright G, McCloy RA, Garama DJ, ... ... Baylin SB, et al. The tumor suppressor Hic1 maintains chromosomal stability independent of Tp53. Oncogene. PMID 29367758 DOI: 10.1038/S41388-017-0022-1  0.511
2018 Zhang H, Pandey S, Travers M, Khowsathit J, Morton G, Sum H, Barrero CA, Merali C, Okamoto Y, Sato T, Garriga J, Bhanu NV, Simithy J, Patel B, Madzo J, ... ... Baylin SB, et al. Abstract 2952: Targeting CDK9 reactivates epigenetically silenced genes in cancer Cancer Research. 78: 2952-2952. DOI: 10.1158/1538-7445.Am2018-2952  0.589
2018 Abbotts R, Topper M, Fontaine D, Biondi C, Choi EY, Lapidus R, Baylin S, Rassool F. Abstract 2823: DNA methyltransferase inhibitors sensitize NSCLC cells to PARP inhibitors by induction of a double strand break repair defect Cancer Research. 78: 2823-2823. DOI: 10.1158/1538-7445.Am2018-2823  0.454
2018 In J, Xie W, Yin J, Kang B, Donowitz M, Kovbasnjuk O, Baylin SB, Easwaran H. 521 - Morphologic and Intestinal Stem Cell Gene Expression Changes in Crispr-Edited APC KO Human Colonoids Gastroenterology. 154: S-115-S-116. DOI: 10.1016/S0016-5085(18)30820-5  0.361
2017 Leadem BR, Kagiampakis I, Wilson C, Cheung TK, Arnott D, Trojer P, Classon M, Easwaran H, Baylin SB. A KDM5 Inhibitor Increases Global H3K4 Trimethylation Occupancy and Enhances the Biological Efficacy of 5-Aza-2'-Deoxycytidine. Cancer Research. PMID 29282222 DOI: 10.1158/0008-5472.Can-17-1453  0.498
2017 Stone ML, Chiappinelli KB, Li H, Murphy LM, Travers ME, Topper MJ, Mathios D, Lim M, Shih IM, Wang TL, Hung CF, Bhargava V, Wiehagen KR, Cowley GS, Bachman KE, ... ... Baylin SB, et al. Epigenetic therapy activates type I interferon signaling in murine ovarian cancer to reduce immunosuppression and tumor burden. Proceedings of the National Academy of Sciences of the United States of America. PMID 29203668 DOI: 10.1073/Pnas.1712514114  0.708
2017 Topper MJ, Vaz M, Chiappinelli KB, DeStefano Shields CE, Niknafs N, Yen RC, Wenzel A, Hicks J, Ballew M, Stone M, Tran PT, Zahnow CA, Hellmann MD, Anagnostou V, Strissel PL, ... ... Baylin SB, et al. Epigenetic Therapy Ties MYC Depletion to Reversing Immune Evasion and Treating Lung Cancer. Cell. 171: 1284-1300.e21. PMID 29195073 DOI: 10.1016/J.Cell.2017.10.022  0.433
2017 Vaz M, Hwang SY, Kagiampakis I, Phallen J, Patil A, O'Hagan HM, Murphy L, Zahnow CA, Gabrielson E, Velculescu VE, Easwaran HP, Baylin SB. Chronic Cigarette Smoke-Induced Epigenomic Changes Precede Sensitization of Bronchial Epithelial Cells to Single-Step Transformation by KRAS Mutations. Cancer Cell. 32: 360-376.e6. PMID 28898697 DOI: 10.1016/J.Ccell.2017.08.006  0.417
2017 Siebenkäs C, Chiappinelli KB, Guzzetta AA, Sharma A, Jeschke J, Vatapalli R, Baylin SB, Ahuja N. Inhibiting DNA methylation activates cancer testis antigens and expression of the antigen processing and presentation machinery in colon and ovarian cancer cells. Plos One. 12: e0179501. PMID 28622390 DOI: 10.1371/journal.pone.0179501  0.378
2017 Xia L, Huang W, Bellani M, Seidman MM, Wu K, Fan D, Nie Y, Cai Y, Zhang YW, Yu LR, Li H, Zahnow CA, Xie W, Chiu Yen RW, Rassool FV, ... Baylin SB, et al. CHD4 Has Oncogenic Functions in Initiating and Maintaining Epigenetic Suppression of Multiple Tumor Suppressor Genes. Cancer Cell. 31: 653-668.e7. PMID 28486105 DOI: 10.1016/J.Ccell.2017.04.005  0.547
2017 Chiappinelli KB, Strissel PL, Desrichard A, Li H, Henke C, Akman B, Hein A, Rote NS, Cope LM, Snyder A, Makarov V, Budhu S, Slamon DJ, Wolchok JD, Pardoll DM, ... ... Baylin SB, et al. Inhibiting DNA Methylation Causes an Interferon Response in Cancer via dsRNA Including Endogenous Retroviruses. Cell. 169: 361. PMID 28388418 DOI: 10.1016/J.Cell.2017.03.036  0.508
2017 Cai Y, Tsai HC, Yen RC, Zhang YW, Kong X, Wang W, Xia L, Baylin SB. Critical threshold levels of DNA methyltransferase 1 are required to maintain DNA methylation across the genome in human cancer cells. Genome Research. PMID 28232479 DOI: 10.1101/Gr.208108.116  0.553
2017 Azad NS, El-Khoueiry A, Yin J, Oberg AL, Flynn P, Adkins D, Sharma A, Weisenberger DJ, Brown T, Medvari P, Jones PA, Easwaran H, Kamel I, Bahary N, Kim G, ... ... Baylin S, et al. Combination epigenetic therapy in metastatic colorectal cancer (mCRC) with subcutaneous 5-azacitidine and entinostat; a phase 2 consortium/stand Up 2 cancer study. Oncotarget. PMID 28186961 DOI: 10.18632/Oncotarget.15108  0.37
2017 Zhang YW, Wang Z, Xie W, Cai Y, Xia L, Easwaran H, Luo J, Yen RC, Li Y, Baylin SB. Acetylation Enhances TET2 Function in Protecting against Abnormal DNA Methylation during Oxidative Stress. Molecular Cell. 65: 323-335. PMID 28107650 DOI: 10.1016/J.Molcel.2016.12.013  0.494
2017 Strissel PL, Chiappinelli KB, Strehl J, Würfel FM, Beckmann MW, Baylin SB, Strick R. Abstract A55: Human endogenous retroviruses differentially regulate immune checkpoints and modulation of immune responses in serous ovarian carcinoma. Cancer Immunology Research. 5. DOI: 10.1158/2326-6074.Tumimm16-A55  0.347
2017 Muvarak N, Chowdhury K, Robert C, Limin X, Choi EY, Cai Y, Bellani M, Seidman M, Baer MR, Lapidus R, Baylin SB, Rassool FV. Abstract IA13: Combination of DNA methyltransferase and PARP inhibitors as a novel therapy strategy for multiple cancers: Key data in AML and triple negative breast cancer Cancer Research. 77. DOI: 10.1158/1538-7445.Newfront17-Ia13  0.441
2017 Anagnostou V, Smith KN, Forde PM, Niknafs N, Bhattacharya R, White J, Adleff V, Phallen J, Wali N, Hruban C, Guthrie VB, Rodgers K, Naidoo J, Kang H, Sharfman W, ... ... Baylin SB, et al. Abstract NG01: Evolution of neoantigen landscape during immune checkpoint blockade in non-small cell lung cancer Cancer Research. 77. DOI: 10.1158/1538-7445.Am2017-Ng01  0.337
2017 Topper M, Vaz M, Chiappinelli K, Shields CD, Wenzel A, Zahnow C, Strissel P, Strick R, Baylin S. Abstract LB-098: Sequential azacitidine and histone deacetylase inhibition induces a potent antitumor response in Kras G12D mouse model of NSCLC Cancer Research. 77. DOI: 10.1158/1538-7445.Am2017-Lb-098  0.422
2017 Zhang H, Raynal NJ-, Sato T, Okamoto Y, Garriga J, Garcia B, Morton G, Childers W, Jacobson MA, Baylin SB, Graña X, Abou-Gharbia M, Issa JJ. Abstract 5064: Identifying novel potential epigenetic anti-cancer drugs from natural compounds using a phenotypic-based screening Cancer Research. 77: 5064-5064. DOI: 10.1158/1538-7445.Am2017-5064  0.465
2017 McLaughlin LJ, Li H, Nagaria P, Baylin SB, Zahnow CA, Rassool FV. Abstract 4045: Decreased Fanconi anemia gene expression contributes to efficacy of PARP and DNMT inhibitor combination therapy in triple negative breast cancer Cancer Research. 77: 4045-4045. DOI: 10.1158/1538-7445.Am2017-4045  0.382
2017 Biondi C, Fontaine D, Stojanovic L, Nagaria P, Lapidus R, Choi EY, Mahmood J, Baylin S, Rassool FV. Abstract 1422: Enhancing the therapeutic effects of PARP inhibitors in combination DNA methyl transferase inhibitors, using low doses of ionizing radiation in non small cell lung cancers Cancer Research. 77: 1422-1422. DOI: 10.1158/1538-7445.Am2017-1422  0.435
2017 Li H, Dimitrakopoulos F, Stone M, Murphy L, Baylin S, Zahnow CA. Abstract 1002: An epigenetic strategy to degrade the estrogen receptor in breast cancer Endocrinology. 77: 1002-1002. DOI: 10.1158/1538-7445.Am2017-1002  0.328
2016 Anagnostou V, Smith KN, Forde PM, Niknafs N, Bhattacharya R, White J, Zhang T, Adleff V, Phallen J, Wali N, Hruban C, Guthrie VB, Rodgers K, Naidoo J, Kang H, ... ... Baylin SB, et al. Evolution of Neoantigen Landscape During Immune Checkpoint Blockade in Non-Small Cell Lung Cancer. Cancer Discovery. PMID 28031159 DOI: 10.1158/2159-8290.Cd-16-0828  0.341
2016 Connolly R, Li H, Jankowitz RC, Zhang Z, Rudek MA, Jeter SC, Slater S, Powers P, Wolff AC, Fetting JH, Brufsky AM, Piekarz R, Ahuja N, Laird PW, Shen H, ... ... Baylin SB, et al. Combination Epigenetic Therapy in Advanced Breast Cancer with 5-Azacitidine and Entinostat: A Phase II National Cancer Institute/Stand Up to Cancer Study. Clinical Cancer Research : An Official Journal of the American Association For Cancer Research. PMID 27979916 DOI: 10.1158/1078-0432.Ccr-16-1729  0.42
2016 Fu T, Liu Y, Li K, Wan W, Pappou EP, Iacobuzio-Donahue CA, Kerner Z, Baylin SB, Wolfgang CL, Ahuja N. Tumors with unmethylated MLH1 and the CpG island methylator phenotype are associated with a poor prognosis in stage II colorectal cancer patients. Oncotarget. PMID 27880934 DOI: 10.18632/Oncotarget.13441  0.394
2016 Hulbert A, Jusue Torres I, Stark A, Chen C, Rodgers K, Lee B, Griffin C, Yang A, Huang P, Wrangle J, Belinsky SA, Wang TH, Yang SC, Baylin SB, Brock MV, et al. Early Detection of Lung Cancer using DNA Promoter Hypermethylation in Plasma and Sputum. Clinical Cancer Research : An Official Journal of the American Association For Cancer Research. PMID 27729459 DOI: 10.1158/1078-0432.Ccr-16-1371  0.418
2016 Muvarak NE, Chowdhury K, Xia L, Robert C, Choi EY, Cai Y, Bellani M, Zou Y, Singh ZN, Duong VH, Rutherford T, Nagaria P, Bentzen SM, Seidman MM, Baer MR, ... ... Baylin SB, et al. Enhancing the Cytotoxic Effects of PARP Inhibitors with DNA Demethylating Agents - A Potential Therapy for Cancer. Cancer Cell. 30: 637-650. PMID 27728808 DOI: 10.1016/J.Ccell.2016.09.002  0.47
2016 Zimmerlin L, Park TS, Huo JS, Verma K, Pather SR, Talbot CC, Agarwal J, Steppan D, Zhang YW, Considine M, Guo H, Zhong X, Gutierrez C, Cope L, Canto-Soler MV, ... ... Baylin SB, et al. Tankyrase inhibition promotes a stable human naïve pluripotent state with improved functionality. Development (Cambridge, England). PMID 27660325 DOI: 10.1242/Dev.138982  0.328
2016 Fu T, Sharmab A, Xie F, Liu Y, Li K, Wan W, Baylin SB, Wolfgang CL, Ahuja N. Methylation of MGMT Is Associated with Poor Prognosis in Patients with Stage III Duodenal Adenocarcinoma. Plos One. 11: e0162929. PMID 27643594 DOI: 10.1371/Journal.Pone.0162929  0.393
2016 Sen S, Block KF, Pasini A, Baylin SB, Easwaran H. Genome-wide positioning of bivalent mononucleosomes. Bmc Medical Genomics. 9: 60. PMID 27634286 DOI: 10.1186/S12920-016-0221-6  0.36
2016 Jones PA, Issa JJ, Baylin S. Targeting the cancer epigenome for therapy. Nature Reviews. Genetics. 17: 630-641. PMID 27629931 DOI: 10.1038/Nrg.2016.93  0.419
2016 Liu M, Ohtani H, Zhou W, Ørskov AD, Charlet J, Zhang YW, Shen H, Baylin SB, Liang G, Grønbæk K, Jones PA. Vitamin C increases viral mimicry induced by 5-aza-2'-deoxycytidine. Proceedings of the National Academy of Sciences of the United States of America. PMID 27573823 DOI: 10.1073/Pnas.1612262113  0.358
2016 Strick R, Strissel PL, Baylin SB, Chiappinelli KB. Unraveling the molecular pathways of DNA-methylation inhibitors: human endogenous retroviruses induce the innate immune response in tumors. Oncoimmunology. 5: e1122160. PMID 27467919 DOI: 10.1080/2162402X.2015.1122160  0.516
2016 Baylin SB. Jacob, Monod, the Lac Operon, and the PaJaMa Experiment-Gene Expression Circuitry Changing the Face of Cancer Research. Cancer Research. 76: 2060-2. PMID 27197249 DOI: 10.1158/0008-5472.Can-16-0865  0.371
2016 Baylin SB, Jones PA. Epigenetic Determinants of Cancer. Cold Spring Harbor Perspectives in Biology. PMID 27194046 DOI: 10.1101/Cshperspect.A019505  0.532
2016 Chiappinelli KB, Strissel PL, Desrichard A, Li H, Henke C, Akman B, Hein A, Rote NS, Cope LM, Snyder A, Makarov V, Budhu S, Slamon DJ, Wolchok JD, Pardoll DM, ... ... Baylin SB, et al. Inhibiting DNA Methylation Causes an Interferon Response in Cancer via dsRNA Including Endogenous Retroviruses. Cell. 164: 1073. PMID 27064190 DOI: 10.1016/J.Cell.2015.10.020  0.508
2016 Zahnow CA, Topper M, Stone M, Murray-Stewart T, Li H, Baylin SB, Casero RA. Inhibitors of DNA Methylation, Histone Deacetylation, and Histone Demethylation: A Perfect Combination for Cancer Therapy. Advances in Cancer Research. 130: 55-111. PMID 27037751 DOI: 10.1016/Bs.Acr.2016.01.007  0.557
2016 Chiappinelli KB, Zahnow CA, Ahuja N, Baylin SB. Combining Epigenetic and Immunotherapy to Combat Cancer. Cancer Research. 76: 1683-9. PMID 26988985 DOI: 10.1158/0008-5472.Can-15-2125  0.432
2016 Ahuja N, Sharma AR, Baylin SB. Epigenetic Therapeutics: A New Weapon in the War Against Cancer. Annual Review of Medicine. 67: 73-89. PMID 26768237 DOI: 10.1146/Annurev-Med-111314-035900  0.563
2016 Dimtrakopoulos FD, Kottorou A, Yang A, Rodgers K, Baylin S, Hulbert A, Brock M. Correlation of exosome concentrations in the plasma of lung cancer patients with disease stage. Journal of Clinical Oncology. 34: e23016-e23016. DOI: 10.1200/Jco.2016.34.15_Suppl.E23016  0.333
2016 Zhang H, Raynal NJ-, Sato T, Okamoto Y, Garcia B, Morton G, Childers W, Jacobson MA, Baylin SB, Abou-Gharbia M, Issa JJ. Abstract B50: A phenotypic screen to identify novel potential epigenetic anticancer drugs from natural compounds Cancer Research. 76. DOI: 10.1158/1538-7445.Chromepi15-B50  0.479
2016 Chiappinelli KB, Strissel PL, Desrichard A, Li H, Henke C, Akman B, Hein A, Rote NS, Cope LM, Snyder A, Makarov V, Budhu S, Wolchok J, Zahnow CA, Mergoub T, ... ... Baylin SB, et al. Abstract B32: Inhibiting DNA methylation causes an interferon response in cancer via dsRNA including endogenous retroviruses Cancer Research. 76. DOI: 10.1158/1538-7445.Chromepi15-B32  0.477
2016 Xie W, Zhang YW, Pan L, Carvlho F, Kang B, Xia L, Murphy L, Zahnow CA, Baylin SB, Easwaran H. Abstract B20: Malignant transformation initiates a stochastic DNA methylation alteration pattern distinct from that in senescence Cancer Research. 76. DOI: 10.1158/1538-7445.Chromepi15-B20  0.571
2016 Vaz M, Hwang SY, Patil A, Easwaran H, Baylin SB. Abstract B18: Chronic cigarette smoke exposure of bronchial epithelial cells induces progressive epigenomic changes leading to early steps of transformation Cancer Research. 76. DOI: 10.1158/1538-7445.Chromepi15-B18  0.54
2016 Ding N, Bonham EM, Hannon BE, Baylin SB, O'Hagan HM. Abstract A18: Mismatch repair proteins recruit DNA methyltransferase 1 to sites of oxidative DNA damage Cancer Research. 76. DOI: 10.1158/1538-7445.Chromepi15-A18  0.48
2016 Rassool FV, Muvarak N, Chowdury K, Robert C, Xia L, Choi EY, Cai Y, Bellani M, Zou Y, Seidman M, Bentzen S, Baer M, Lapidus R, Baylin SB. Abstract LB-205: Combination of DNA methyltransferase and PARP inhibitors as a novel therapy strategy for poor prognosis acute myeloid leukemia and triple-negative breast cancers Cancer Research. 76. DOI: 10.1158/1538-7445.Am2016-Lb-205  0.458
2016 Lee V, Wang J, Khoueiry AE, Verheul H, Gootjes E, Sharma A, Kerner Z, Jones P, Baylin S, Lilly E, Ahuja N, Brown T, Azad N. Abstract CT017: A phase I study of guadecitabine (GUA) combined with irinotecan (IRI) in previously treated metastatic colorectal cancer (mCRC) patients Cancer Research. 76. DOI: 10.1158/1538-7445.Am2016-Ct017  0.331
2016 Stone ML, Chiappinelli KB, Li H, Murphy L, Topper M, Baylin S, Zahnow C. Abstract 4907: Epigenetic treatment of ovarian cancer cells increases immune cell recruitment to the tumor microenvironment: implications for response to immune checkpoint therapy Cancer Research. 76: 4907-4907. DOI: 10.1158/1538-7445.Am2016-4907  0.384
2016 Zhang H, Raynal NJ-, Sato T, Okamoto Y, Garriga J, Morton G, Childers W, Jacobson MA, Baylin SB, Graña X, Abou-Gharbia M, Issa JJ. Abstract 4701: A phenotypic cell-based screen to identify novel potential epigenetic anti-cancer drugs from natural compounds Cancer Research. 76: 4701-4701. DOI: 10.1158/1538-7445.Am2016-4701  0.453
2016 Topper M, Hanigan C, Vaz M, Chiappinelli K, Justin J, Murphy L, Zahnow C, Baylin S. Abstract 4653: Combination Azacitidine and histone deacetylase inhibition induces a multi factorial synergistic anti-tumor response in non-small cell lung cancer (NSCLC) Cancer Research. 76: 4653-4653. DOI: 10.1158/1538-7445.Am2016-4653  0.515
2016 Chen C, Yang A, Danielle D, Rodgers K, Huang P, Lu Z, Griffin C, Lee B, Battafarano R, Yu F, Wang T, Baylin S, Herman J, Hulbert A, Brock M. Abstract 4455: DNA methylation as biomarkers to predict early recurrence of T1-2N0 lung cancer Cancer Research. 76: 4455-4455. DOI: 10.1158/1538-7445.Am2016-4455  0.459
2016 Kang B, In J, Zachos N, Huso D, Maegawa S, Issa J, Easwaran H, Baylin SB. Abstract 4273: Oncogenic BRAFV600E drives stem cell niche factors-independent growth and tumorigenic transformation in colon organoids Cancer Research. 76: 4273-4273. DOI: 10.1158/1538-7445.Am2016-4273  0.458
2016 Chiappinelli KB, Stone ML, Topper MJ, Murphy L, Strissel PL, Strick R, Zahnow CA, Baylin SB. Abstract 4019: Inhibiting DNA methylation causes an interferon response in cancer cells via endogenous retroviruses and recruits immune cells to the tumor microenvironment to sensitize to immune therapy Cancer Research. 76: 4019-4019. DOI: 10.1158/1538-7445.Am2016-4019  0.435
2016 Vaz MP, Hwang SY, Patil A, Phallen J, Murphy L, Zahnow CA, Velculescu VE, Easwaran H, Baylin SB. Abstract 2773: Chronic cigarette smoke exposure of bronchial epithelial cells induces progressive epigenomic changes leading to transformation Cancer Research. 76: 2773-2773. DOI: 10.1158/1538-7445.Am2016-2773  0.496
2016 Zambidis E, Zimmerlin L, Park TS, Huo JS, Verma K, Pather S, Talbot C, Agarwal J, Steppan D, Considine M, Guo H, Zhang Y, Cope L, Friedman A, Baylin S. Stable Reversion of Conventional Human Pluripotent Stem Cells to a Mouse ESC-like Naïve Ground State Erases Somatic Donor Epigenetic Memory and Significantly Improves Their Hemato-Vascular Differentiation Potency Biology of Blood and Marrow Transplantation. 22: S426. DOI: 10.1016/J.Bbmt.2015.11.972  0.304
2015 Raynal NJ, Lee JT, Wang Y, Beaudry A, Madireddi P, Garriga J, Malouf GG, Dumont S, Dettman EJ, Gharibyan V, Ahmed S, Chung W, Childers WE, Abou-Gharbia M, Henry RA, ... ... Baylin SB, et al. Targeting calcium signaling induces epigenetic reactivation of tumor suppressor genes in cancer. Cancer Research. PMID 26719529 DOI: 10.1158/0008-5472.Can-14-2391  0.516
2015 Baylin SB. Interview with Stephen B Baylin. Epigenomics. 7: 881-3. PMID 26418030 DOI: 10.2217/Epi.15.61  0.485
2015 Chiappinelli KB, Strissel PL, Desrichard A, Li H, Henke C, Akman B, Hein A, Rote NS, Cope LM, Snyder A, Makarov V, Buhu S, Slamon DJ, Wolchok JD, Pardoll DM, ... ... Baylin SB, et al. Inhibiting DNA Methylation Causes an Interferon Response in Cancer via dsRNA Including Endogenous Retroviruses. Cell. 162: 974-86. PMID 26317466 DOI: 10.1016/J.Cell.2015.07.011  0.454
2015 Ding N, Bonham EM, Hannon BE, Amick TR, Baylin SB, O'Hagan HM. Mismatch repair proteins recruit DNA methyltransferase 1 to sites of oxidative DNA damage. Journal of Molecular Cell Biology. PMID 26186941 DOI: 10.1093/Jmcb/Mjv050  0.366
2015 Calmon MF, Jeschke J, Zhang W, Dhir M, Siebenkäs C, Herrera A, Tsai HC, O'Hagan HM, Pappou EP, Hooker CM, Fu T, Schuebel KE, Gabrielson E, Rahal P, Herman JG, ... Baylin SB, et al. Epigenetic silencing of neurofilament genes promotes an aggressive phenotype in breast cancer. Epigenetics. 10: 622-32. PMID 25985363 DOI: 10.1080/15592294.2015.1050173  0.43
2015 Juo YY, Gong XJ, Mishra A, Cui X, Baylin SB, Azad NS, Ahuja N. Epigenetic therapy for solid tumors: from bench science to clinical trials. Epigenomics. 7: 215-35. PMID 25942532 DOI: 10.2217/Epi.14.73  0.488
2015 Fu T, Pappou EP, Guzzetta AA, Calmon MF, Sun L, Herrera A, Li F, Wolfgang CL, Baylin SB, Iacobuzio-Donahue CA, Tong W, Ahuja N. IGFBP-3 Gene Methylation in Primary Tumor Predicts Recurrence of Stage II Colorectal Cancers. Annals of Surgery. PMID 25822686 DOI: 10.1097/Sla.0000000000001204  0.429
2015 Melotte V, Yi JM, Lentjes MH, Smits KM, Van Neste L, Niessen HE, Wouters KA, Louwagie J, Schuebel KE, Herman JG, Baylin SB, van Criekinge W, Meijer GA, Ahuja N, van Engeland M. Spectrin repeat containing nuclear envelope 1 and forkhead box protein E1 are promising markers for the detection of colorectal cancer in blood. Cancer Prevention Research (Philadelphia, Pa.). 8: 157-64. PMID 25538088 DOI: 10.1158/1940-6207.Capr-14-0198  0.417
2015 Vendetti FP, Topper M, Huang P, Dobromilskaya I, Easwaran H, Wrangle J, Baylin SB, Poirier JT, Rudin CM. Evaluation of azacitidine and entinostat as sensitization agents to cytotoxic chemotherapy in preclinical models of non-small cell lung cancer. Oncotarget. 6: 56-70. PMID 25474141 DOI: 10.18632/Oncotarget.2695  0.412
2015 Reiss KA, Ahuja N, Baylin S, Mauro LA, Linden S, White S, Laheru DA, Herman JM, Wolfgang CL, Weiss MJ, Cameron JL, Makary M, Azad NS. A randomized phase II trial of epigenetic therapy following adjuvant treatment in patients with resected pancreatic cancer and high risk for recurrence. Journal of Clinical Oncology. 33: TPS4144-TPS4144. DOI: 10.1200/Jco.2015.33.15_Suppl.Tps4144  0.428
2015 Reiss KA, Rudek MA, Sartorius-Mergenthaler S, Downs M, Cosgrove D, Gaillard S, Baylin S, Ahuja N, Azad NS. A phase I trial of oral 5-azacitidine in combination with romidepsin in advanced solid tumors with an expansion cohort in virally mediated cancers and liposarcoma. Journal of Clinical Oncology. 33: TPS2619-TPS2619. DOI: 10.1200/Jco.2015.33.15_Suppl.Tps2619  0.473
2015 Tsai H, Easwaran H, Baylin SB. Abstract B27: Epigenetic regulation of stem cell fate in leukemic subpopulations. Clinical Cancer Research. 21. DOI: 10.1158/1557-3265.Hemmal14-B27  0.444
2015 Chiappinelli KB, Strissel P, Yen RC, Li H, Stone ML, Murphy L, Akman B, Zahnow CA, Strick R, Baylin SB. Abstract NG07: Immunomodulatory and tumor cell killing effects of the demethylating agent 5-azacytidine in ovarian cancer Cancer Research. 75. DOI: 10.1158/1538-7445.Am2015-Ng07  0.39
2015 Cai Y, Tsai H, Yen R, Xia L, Zhang Y, Baylin S. Abstract LB-150: Genetic depletion of DNMT1 reveals a DNMT1 threshold controlling DNA methylation in human cells Cancer Research. 75. DOI: 10.1158/1538-7445.Am2015-Lb-150  0.577
2015 He K, Zhang X, Danilova L, Pan X, Brahmer J, Pardoll D, Brock M, Baylin S, Herman J, Wrangle J. Abstract 5033: Azacitidine pretreatment sensitizes NSCLC cells to interferon-γ Cancer Research. 75: 5033-5033. DOI: 10.1158/1538-7445.Am2015-5033  0.411
2015 Chowdhury K, Lapidus RG, Choi EY, Baylin S, Rassool FV. Abstract 2948: Combination treatment of PARP inhibitor, BMN 673 and DNMT inhibitor, Azacytidine: A potential therapy for BRCA negative and positive, triple negative breast cancers Cancer Research. 75: 2948-2948. DOI: 10.1158/1538-7445.Am2015-2948  0.428
2015 Zhang Y, Cai Y, Xie W, Easwaran H, Baylin SB. Abstract 2864: Acetylation regulates TET2 stability and enzymatic activity Cancer Research. 75: 2864-2864. DOI: 10.1158/1538-7445.Am2015-2864  0.53
2015 Muvarak NE, Robert C, Nagaria PK, Chowdhury K, Choi EY, Duong V, Emadi A, Baer MR, Lapidus R, Baylin S, Rassool F. Abstract 2848: Combination of DNA methyltransferase and PARP inhibitors as a novel therapy strategy for poor prognosis acute myeloid leukemia Cancer Research. 75: 2848-2848. DOI: 10.1158/1538-7445.Am2015-2848  0.419
2015 Baylin SB, Roberts C, Shilatifard A. Part 4: Targeting cancer pathways: The epigenetics question Science. 349. DOI: 10.1126/Science.349.6248.656-C  0.479
2015 Chiappinelli KB, Strissel PL, Desrichard A, Li H, Henke C, Akman B, Hein A, Rote NS, Cope LM, Snyder A, Makarov V, Buhu S, Slamon DJ, Wolchok JD, Pardoll DM, ... ... Baylin SB, et al. Inhibiting DNA Methylation Causes an Interferon Response in Cancer via dsRNA Including Endogenous Retroviruses Cell. 162: 974-986. DOI: 10.1016/j.cell.2015.07.011  0.411
2014 Huo JS, Baylin SB, Zambidis ET. Cancer-like epigenetic derangements of human pluripotent stem cells and their impact on applications in regeneration and repair. Current Opinion in Genetics & Development. 28: 43-9. PMID 25461449 DOI: 10.1016/J.Gde.2014.09.008  0.43
2014 Easwaran H, Tsai HC, Baylin SB. Cancer epigenetics: tumor heterogeneity, plasticity of stem-like states, and drug resistance. Molecular Cell. 54: 716-27. PMID 24905005 DOI: 10.1016/J.Molcel.2014.05.015  0.425
2014 Cui Y, Hausheer F, Beaty R, Zahnow C, Issa JP, Bunz F, Baylin SB. A recombinant reporter system for monitoring reactivation of an endogenously DNA hypermethylated gene. Cancer Research. 74: 3834-43. PMID 24876104 DOI: 10.1158/0008-5472.Can-13-2287  0.608
2014 Juo YY, Johnston FM, Zhang DY, Juo HH, Wang H, Pappou EP, Yu T, Easwaran H, Baylin S, van Engeland M, Ahuja N. Prognostic value of CpG island methylator phenotype among colorectal cancer patients: a systematic review and meta-analysis. Annals of Oncology : Official Journal of the European Society For Medical Oncology / Esmo. 25: 2314-27. PMID 24718889 DOI: 10.1093/Annonc/Mdu149  0.395
2014 Li H, Chiappinelli KB, Guzzetta AA, Easwaran H, Yen RW, Vatapalli R, Topper MJ, Luo J, Connolly RM, Azad NS, Stearns V, Pardoll DM, Davidson N, Jones PA, Slamon DJ, ... Baylin SB, et al. Immune regulation by low doses of the DNA methyltransferase inhibitor 5-azacitidine in common human epithelial cancers. Oncotarget. 5: 587-98. PMID 24583822 DOI: 10.18632/Oncotarget.1782  0.546
2014 Wee S, Dhanak D, Li H, Armstrong SA, Copeland RA, Sims R, Baylin SB, Liu XS, Schweizer L. Targeting epigenetic regulators for cancer therapy. Annals of the New York Academy of Sciences. 1309: 30-6. PMID 24571255 DOI: 10.1111/Nyas.12356  0.519
2014 Sun L, Guzzetta AA, Fu T, Chen J, Jeschke J, Kwak R, Vatapalli R, Baylin SB, Iacobuzio-Donahue CA, Wolfgang CL, Ahuja N. CpG island methylator phenotype and its association with malignancy in sporadic duodenal adenomas. Epigenetics. 9: 738-46. PMID 24518818 DOI: 10.4161/epi.28082  0.345
2014 Wrangle J, Machida EO, Danilova L, Hulbert A, Franco N, Zhang W, Glöckner SC, Tessema M, Van Neste L, Easwaran H, Schuebel KE, Licchesi J, Hooker CM, Ahuja N, Amano J, ... ... Baylin SB, et al. Functional identification of cancer-specific methylation of CDO1, HOXA9, and TAC1 for the diagnosis of lung cancer Clinical Cancer Research. 20: 1856-1864. PMID 24486589 DOI: 10.1158/1078-0432.Ccr-13-2109  0.406
2014 Weinstein JN, Akbani R, Broom BM, Wang W, Verhaak RGW, McConkey D, Lerner S, Morgan M, Creighton CJ, Smith C, Cherniack AD, Kim J, Pedamallu CS, Noble MS, Al-Ahmadie HA, ... ... Baylin SB, et al. Comprehensive molecular characterization of urothelial bladder carcinoma Nature. 507: 315-322. PMID 24476821 DOI: 10.1038/Nature12965  0.424
2014 Ahuja N, Easwaran H, Baylin SB. Harnessing the potential of epigenetic therapy to target solid tumors. The Journal of Clinical Investigation. 124: 56-63. PMID 24382390 DOI: 10.1172/Jci69736  0.37
2014 Connolly RM, Jankowitz RC, Zahnow CA, Zhang Z, Rudek MA, Slater S, Powers P, Jeter S, Brufsky A, Piekarz R, Herman JG, Ahuja N, Somlo G, Garcia AA, Baylin S, et al. Phase 2 study investigating the safety, efficacy, and surrogate biomarkers of response to 5-azacitidine (5-AZA) and entinostat in advanced breast cancer. Journal of Clinical Oncology. 32: 569-569. DOI: 10.1200/Jco.2014.32.15_Suppl.569  0.444
2014 Szczepny A, McKenzie L, Jayesekara S, Russell P, Wright G, Baylin SB, Rossello FJ, Cain JE, Watkins DN. Abstract LB-81: Conditional deletion of the tumor suppressor Hic1 results in aneuploidy and single-step transformation Cancer Research. 74. DOI: 10.1158/1538-7445.Am2014-Lb-81  0.468
2014 Mitchell KA, Easwaran H, Baylin SB. Abstract 4779: DNMT3B (a de novo DNA methyltransferase) epigenetically regulates gene expression, independent of its DNA methyltransferase activity Cancer Research. 74: 4779-4779. DOI: 10.1158/1538-7445.Am2014-4779  0.616
2014 Raynal NJ, Lee JT, Wang Y, Garriga J, Malouf G, Dumont S, Dettman EJ, Gharibyan V, Ahmed S, Chung W, Childers WE, Abou-Gharbia M, Henry RA, Andrews A, Jelinek J, ... ... Baylin SB, et al. Abstract 380: Discovery of new epigenetic drugs among FDA-approved drug libraries Cancer Research. 74: 380-380. DOI: 10.1158/1538-7445.Am2014-380  0.46
2013 Wrangle J, Wang W, Koch A, Easwaran H, Mohammad HP, Vendetti F, Vancriekinge W, Demeyer T, Du Z, Parsana P, Rodgers K, Yen RW, Zahnow CA, Taube JM, Brahmer JR, ... ... Baylin SB, et al. Alterations of immune response of Non-Small Cell Lung Cancer with Azacytidine. Oncotarget. 4: 2067-79. PMID 24162015 DOI: 10.18632/Oncotarget.1542  0.398
2013 Yi JM, Guzzetta AA, Bailey VJ, Downing SR, Van Neste L, Chiappinelli KB, Keeley BP, Stark A, Herrera A, Wolfgang C, Pappou EP, Iacobuzio-Donahue CA, Goggins MG, Herman JG, Wang TH, ... Baylin SB, et al. Novel methylation biomarker panel for the early detection of pancreatic cancer. Clinical Cancer Research : An Official Journal of the American Association For Cancer Research. 19: 6544-55. PMID 24088737 DOI: 10.1158/1078-0432.Ccr-12-3224  0.449
2013 Borodovsky A, Salmasi V, Turcan S, Fabius AW, Baia GS, Eberhart CG, Weingart JD, Gallia GL, Baylin SB, Chan TA, Riggins GJ. 5-azacytidine reduces methylation, promotes differentiation and induces tumor regression in a patient-derived IDH1 mutant glioma xenograft. Oncotarget. 4: 1737-47. PMID 24077805 DOI: 10.18632/Oncotarget.1408  0.427
2013 Keeley B, Stark A, Pisanic TR, Kwak R, Zhang Y, Wrangle J, Baylin S, Herman J, Ahuja N, Brock MV, Wang TH. Extraction and processing of circulating DNA from large sample volumes using methylation on beads for the detection of rare epigenetic events. Clinica Chimica Acta; International Journal of Clinical Chemistry. 425: 169-75. PMID 23911908 DOI: 10.1016/J.Cca.2013.07.023  0.435
2013 Di Cello F, Cope L, Li H, Jeschke J, Wang W, Baylin SB, Zahnow CA. Methylation of the claudin 1 promoter is associated with loss of expression in estrogen receptor positive breast cancer. Plos One. 8: e68630. PMID 23844228 DOI: 10.1371/journal.pone.0068630  0.377
2013 Cai Y, Geutjes EJ, de Lint K, Roepman P, Bruurs L, Yu LR, Wang W, van Blijswijk J, Mohammad H, de Rink I, Bernards R, Baylin SB. The NuRD complex cooperates with DNMTs to maintain silencing of key colorectal tumor suppressor genes. Oncogene. 33: 2157-68. PMID 23708667 DOI: 10.1038/Onc.2013.178  0.588
2013 Jeschke J, O'Hagan HM, Zhang W, Vatapalli R, Calmon MF, Danilova L, Nelkenbrecher C, Van Neste L, Bijsmans IT, Van Engeland M, Gabrielson E, Schuebel KE, Winterpacht A, Baylin SB, Herman JG, et al. Frequent inactivation of cysteine dioxygenase type 1 contributes to survival of breast cancer cells and resistance to anthracyclines. Clinical Cancer Research : An Official Journal of the American Association For Cancer Research. 19: 3201-11. PMID 23630167 DOI: 10.1158/1078-0432.Ccr-12-3751  0.458
2013 Azad N, Zahnow CA, Rudin CM, Baylin SB. The future of epigenetic therapy in solid tumours--lessons from the past. Nature Reviews. Clinical Oncology. 10: 256-66. PMID 23546521 DOI: 10.1038/Nrclinonc.2013.42  0.375
2013 Pandiyan K, You JS, Yang X, Dai C, Zhou XJ, Baylin SB, Jones PA, Liang G. Functional DNA demethylation is accompanied by chromatin accessibility. Nucleic Acids Research. 41: 3973-85. PMID 23408854 DOI: 10.1093/Nar/Gkt077  0.862
2013 Easwaran H, Baylin SB. Epigenetic abnormalities in cancer find a "home on the range". Cancer Cell. 23: 1-3. PMID 23328477 DOI: 10.1016/J.Ccr.2012.12.018  0.499
2013 Azad NS, El-Khoueiry AB, Mahoney MR, Adkins D, Flynn PJ, Bahary N, Kim GP, Pitot HC, Erlichman C, Donehower RC, Herman JG, Baylin S, Ahuja N. A phase II study of combination epigenetic therapy in metastatic colorectal cancer (mCRC): A phase II consortium (P2C)/Stand Up 2 Cancer (SU2C) study. Journal of Clinical Oncology. 31: 3539-3539. DOI: 10.1200/Jco.2013.31.15_Suppl.3539  0.405
2013 Robert C, Muvarak NE, Duong VH, Baer MR, Baylin SB, Rassool F. Demethylating Agents Reprogram Myelodysplastic Syndrome and Leukemia Cells, Sensitizing Them To Poly-(ADP)-Ribose Polymerase Inhibitors Blood. 122: 3778-3778. DOI: 10.1182/Blood.V122.21.3778.3778  0.44
2013 Wrangle J, Wang W, Koch A, Easwaran H, Mohammad H, Parsana P, Vendetti F, Rodgers K, Pan X, Harbom K, Zahnow C, Taube J, Brahmer J, Jones P, Topalian S, ... ... Baylin S, et al. Abstract 4619: Epigenetic therapy and sensitization of lung cancer to immunotherapy. Cancer Research. 73: 4619-4619. DOI: 10.1158/1538-7445.Am2013-4619  0.486
2013 Chiappinelli KB, Yen RC, Li H, Topper M, Zahnow CA, Baylin SB. Abstract PR12: Immunomodulatory effects of 5-Azacyditine in ovarian cancer cell lines Clinical Cancer Research. 19. DOI: 10.1158/1078-0432.Ovca13-Pr12  0.49
2013 Guzzetta A, Kwak R, Vatapalli R, Syed L, Koch A, Easwaran H, Baylin S, Ahuja N. Epigenetic Upregulation of Beta-2 Microglobulin in Microsatellite Stable Colon Cancer Cell Lines Journal of Surgical Research. 179: 339. DOI: 10.1016/J.Jss.2012.10.764  0.38
2012 Fu T, Pappou EP, Guzzetta AA, Jeschke J, Kwak R, Dave P, Hooker CM, Morgan R, Baylin SB, Iacobuzio-Donahue CA, Wolfgang CL, Ahuja N. CpG island methylator phenotype-positive tumors in the absence of MLH1 methylation constitute a distinct subset of duodenal adenocarcinomas and are associated with poor prognosis. Clinical Cancer Research : An Official Journal of the American Association For Cancer Research. 18: 4743-52. PMID 22825585 DOI: 10.1158/1078-0432.CCR-12-0707  0.401
2012 Jeschke J, Van Neste L, Glöckner SC, Dhir M, Calmon MF, Deregowski V, Van Criekinge W, Vlassenbroeck I, Koch A, Chan TA, Cope L, Hooker CM, Schuebel KE, Gabrielson E, Winterpacht A, ... Baylin SB, et al. Biomarkers for detection and prognosis of breast cancer identified by a functional hypermethylome screen. Epigenetics. 7: 701-9. PMID 22647880 DOI: 10.4161/Epi.20445  0.364
2012 Leng S, Do K, Yingling CM, Picchi MA, Wolf HJ, Kennedy TC, Feser WJ, Baron AE, Franklin WA, Brock MV, Herman JG, Baylin SB, Byers T, Stidley CA, Belinsky SA. Defining a gene promoter methylation signature in sputum for lung cancer risk assessment. Clinical Cancer Research : An Official Journal of the American Association For Cancer Research. 18: 3387-95. PMID 22510351 DOI: 10.1158/1078-0432.Ccr-11-3049  0.46
2012 Tsai HC, Li H, Van Neste L, Cai Y, Robert C, Rassool FV, Shin JJ, Harbom KM, Beaty R, Pappou E, Harris J, Yen RW, Ahuja N, Brock MV, Stearns V, ... ... Baylin SB, et al. Transient low doses of DNA-demethylating agents exert durable antitumor effects on hematological and epithelial tumor cells. Cancer Cell. 21: 430-46. PMID 22439938 DOI: 10.1016/J.Ccr.2011.12.029  0.517
2012 Easwaran H, Johnstone SE, Van Neste L, Ohm J, Mosbruger T, Wang Q, Aryee MJ, Joyce P, Ahuja N, Weisenberger D, Collisson E, Zhu J, Yegnasubramanian S, Matsui W, Baylin SB. A DNA hypermethylation module for the stem/progenitor cell signature of cancer. Genome Research. 22: 837-49. PMID 22391556 DOI: 10.1101/Gr.131169.111  0.585
2012 Easwaran H, Baylin SB. Biomarkers for EGFR-antagonist response: in the genes and on the genes! Clinical Cancer Research : An Official Journal of the American Association For Cancer Research. 18: 2121-3. PMID 22371454 DOI: 10.1158/1078-0432.Ccr-12-0157  0.338
2012 Clements EG, Mohammad HP, Leadem BR, Easwaran H, Cai Y, Van Neste L, Baylin SB. DNMT1 modulates gene expression without its catalytic activity partially through its interactions with histone-modifying enzymes. Nucleic Acids Research. 40: 4334-46. PMID 22278882 DOI: 10.1093/Nar/Gks031  0.82
2012 Wrangle J, Mohammad HP, Abukhdeir A, Juergens RA, Harbom K, Rodgers K, Shin J, Zahnow CA, Baylin S, Herman JG, Rudin CM, Brock M. Predicting sensitivity to azacytidine in non-small cell cancer lines by absence of activating mutations. Journal of Clinical Oncology. 30: e18147-e18147. DOI: 10.1200/Jco.2012.30.15_Suppl.E18147  0.374
2012 Govindan R, Hammerman PS, Hayes DN, Wilkerson MD, Baylin S, Meyerson M. Comprehensive genomic characterization of squamous cell carcinoma of the lung. Journal of Clinical Oncology. 30: 7006-7006. DOI: 10.1200/Jco.2012.30.15_Suppl.7006  0.316
2012 Berman BP, Weisenberger DJ, Hinoue T, Noushmehr H, Liu Y, Aman JF, Hinoue T, Shen H, Malik S, Mahurkar S, Triche T, Ramjan Z, Nicolet CM, Van Den Berg D, Cope L, ... ... Baylin SB, et al. Exploring the cancer methylome Bmc Proceedings. 6. DOI: 10.1186/1753-6561-6-S6-O24  0.562
2012 Cai Y, Geutjes E, Roepman P, Yu L, Blijswijk JV, Wang W, Mohammad H, Rink Id, Baylin S, Bernards R. Abstract LB-386: The NuRD complex cooperates with DNMTs to maintain silencing of colorectal tumor suppressor genes. Cancer Research. 72. DOI: 10.1158/1538-7445.Am2012-Lb-386  0.569
2012 Tsai H, Li H, Neste LV, Cai Y, Robert C, Rassool FV, Shin JJ, Harbom KM, Beaty R, Pappou E, Harris J, Yen RC, Ahuja N, Brock MV, Stearns V, ... ... Baylin SB, et al. Abstract 995: Transient low doses of DNA demethylating agents exert durable antitumor effects on hematological and epithelial tumor cells Cancer Research. 72: 995-995. DOI: 10.1158/1538-7445.Am2012-995  0.533
2012 Jeschke J, O'Hagan H, Zhang W, Calmon MF, Dhir M, Neste Lv, Bijsmans I, Gabrielson E, Schuebel KE, Baylin SB, Winterpacht A, Herman JG, Ahuja N. Abstract 94: Epigenetic silencing of CDO1 sustains viability of breast cancer cells via the reduction of cellular ROS Cancer Research. 72: 94-94. DOI: 10.1158/1538-7445.Am2012-94  0.512
2011 Juergens RA, Wrangle J, Vendetti FP, Murphy SC, Zhao M, Coleman B, Sebree R, Rodgers K, Hooker CM, Franco N, Lee B, Tsai S, Delgado IE, Rudek MA, Belinsky SA, ... ... Baylin SB, et al. Combination epigenetic therapy has efficacy in patients with refractory advanced non-small cell lung cancer. Cancer Discovery. 1: 598-607. PMID 22586682 DOI: 10.1158/2159-8290.Cd-11-0214  0.436
2011 O'Hagan HM, Wang W, Sen S, Destefano Shields C, Lee SS, Zhang YW, Clements EG, Cai Y, Van Neste L, Easwaran H, Casero RA, Sears CL, Baylin SB. Oxidative damage targets complexes containing DNA methyltransferases, SIRT1, and polycomb members to promoter CpG Islands. Cancer Cell. 20: 606-19. PMID 22094255 DOI: 10.1016/J.Ccr.2011.09.012  0.835
2011 Baylin SB, Jones PA. A decade of exploring the cancer epigenome - biological and translational implications. Nature Reviews. Cancer. 11: 726-34. PMID 21941284 DOI: 10.1038/Nrc3130  0.538
2011 Fan J, Robert C, Jang YY, Liu H, Sharkis S, Baylin SB, Rassool FV. Human induced pluripotent cells resemble embryonic stem cells demonstrating enhanced levels of DNA repair and efficacy of nonhomologous end-joining. Mutation Research. 713: 8-17. PMID 21718709 DOI: 10.1016/J.Mrfmmm.2011.05.018  0.384
2011 Easwaran HP, Baylin SB. Role of nuclear architecture in epigenetic alterations in cancer. Cold Spring Harbor Symposia On Quantitative Biology. 75: 507-15. PMID 21447817 DOI: 10.1101/sqb.2010.75.031  0.374
2011 Fang F, Turcan S, Rimner A, Kaufman A, Giri D, Morris LG, Shen R, Seshan V, Mo Q, Heguy A, Baylin SB, Ahuja N, Viale A, Massague J, Norton L, et al. Breast cancer methylomes establish an epigenomic foundation for metastasis. Science Translational Medicine. 3: 75ra25. PMID 21430268 DOI: 10.1126/Scitranslmed.3001875  0.424
2011 Baylin SB. Resistance, epigenetics and the cancer ecosystem. Nature Medicine. 17: 288-9. PMID 21383739 DOI: 10.1038/Nm0311-288  0.377
2011 Tsai HC, Baylin SB. Cancer epigenetics: linking basic biology to clinical medicine. Cell Research. 21: 502-17. PMID 21321605 DOI: 10.1038/Cr.2011.24  0.54
2011 Mohammad HP, Zhang W, Prevas HS, Leadem BR, Zhang M, Herman JG, Hooker CM, Watkins DN, Karim B, Huso DL, Baylin SB. Loss of a single Hic1 allele accelerates polyp formation in Apc Δ716 mice Oncogene. 30: 2659-2669. PMID 21297660 DOI: 10.1038/Onc.2010.633  0.465
2011 Yi JM, Dhir M, Van Neste L, Downing SR, Jeschke J, Glöckner SC, de Freitas Calmon M, Hooker CM, Funes JM, Boshoff C, Smits KM, van Engeland M, Weijenberg MP, Iacobuzio-Donahue CA, Herman JG, ... ... Baylin SB, et al. Genomic and epigenomic integration identifies a prognostic signature in colon cancer. Clinical Cancer Research : An Official Journal of the American Association For Cancer Research. 17: 1535-45. PMID 21278247 DOI: 10.1158/1078-0432.Ccr-10-2509  0.384
2011 Belinsky SA, Grimes MJ, Picchi MA, Mitchell HD, Stidley CA, Tesfaigzi Y, Channell MM, Liu Y, Casero RA, Baylin SB, Reed MD, Tellez CS, March TH. Combination therapy with vidaza and entinostat suppresses tumor growth and reprograms the epigenome in an orthotopic lung cancer model. Cancer Research. 71: 454-62. PMID 21224363 DOI: 10.1158/0008-5472.Can-10-3184  0.491
2011 Dhir M, Yachida S, Van Neste L, Glöckner SC, Jeschke J, Pappou EP, Montgomery EA, Herman JG, Baylin SB, Iacobuzio-Donahue C, Ahuja N. Sessile serrated adenomas and classical adenomas: an epigenetic perspective on premalignant neoplastic lesions of the gastrointestinal tract. International Journal of Cancer. 129: 1889-98. PMID 21154739 DOI: 10.1002/Ijc.25847  0.474
2011 Juergens R, Vendetti F, Wrangle J, Coleman B, Sebree R, Rudek-Renaut M, Belinsky S, Brock M, Herman J, Baylin S, Rudin C. Abstract LB-411: A phase II study of combination epigenetic therapy in advanced non-small cell lung cancer Cancer Research. 71. DOI: 10.1158/1538-7445.Am2011-Lb-411  0.387
2011 O'Hagan HM, Wang W, Sen S, Lee SS, Clements EG, Cai Y, Neste LV, Easwaran H, Baylin SB. Abstract LB-185: Oxidative damage targets complexes containing DNA methyltransferases, SIRT1 and polycomb members to promoter CpG islands Cancer Research. 71. DOI: 10.1158/1538-7445.Am2011-Lb-185  0.57
2011 Easwaran H, Johnstone SE, Neste LV, Ohm JE, Mosbruger T, Aryee M, Yegnasubramanian S, Matsui W, Baylin SB. Abstract LB-174: A DNA hypermethylation module for the stem/progenitor cell signature of cancer Cancer Research. 71. DOI: 10.1158/1538-7445.Am2011-Lb-174  0.603
2011 Du Z, Wrangle J, Pelosky K, Harris J, Shin J, Vendetti F, Hulbert A, Lee B, Zahnow C, Ahuja N, Herman J, Baylin S, Brock M. Abstract 2618: DNMT1 as a marker of differential sensitivities to epigenetic therapy of a Kras mutant and Kras wild type human non small cell lung cancer cell line Cancer Research. 71: 2618-2618. DOI: 10.1158/1538-7445.Am2011-2618  0.417
2011 Harris JE, Shin J, Lee B, Pelosky K, Zahnow C, Brayton C, Yang S, Baylin S, Brock MV. Abstract 1600: A xenograft model of spontaneous metastases in NOD SCID mice of human non-small cell lung cancer Cancer Research. 71: 1600-1600. DOI: 10.1158/1538-7445.Am2011-1600  0.307
2011 Zahnow CA, Li H, Baylin SB. Abstract CN06-01: Low-dose azacytidine and epigenetic regulation of self-renewal. Molecular Cancer Therapeutics. 10. DOI: 10.1158/1535-7163.Targ-11-Cn06-01  0.492
2011 Brock MV, Juergens RA, Wrangle J, Vendetti FP, Murphy S, Zhao M, Coleman B, Sebree R, Rodgers K, Hooker CM, Franco N, Lee B, Tsai S, Delgado IE, Rudek MA, ... ... Baylin SB, et al. Abstract ED03-04: Using epigenetic biomarkers as prognostic and predictive markers in non-small cell lung cancer (NSCLC) and the promise of epigenetic therapy Cancer Epidemiology, Biomarkers & Prevention. 20. DOI: 10.1158/1055-9965.Disp-11-Ed03-04  0.523
2011 Yi JM, Bailey V, Downing S, Goggins M, Yang KM, Wang T, Herman J, Baylin SB, Ahuja N. Abstract B43: Early detection biomarker of pancreatic cancer using a nanoparticle-based methylation assay Cancer Epidemiology, Biomarkers & Prevention. 20. DOI: 10.1158/1055-9965.Disp-11-B43  0.512
2011 Connolly R, Jankowitz R, Andreopoulou E, Allred J, Jeter S, Zorzi J, Adam B, Espinoza-Delgado I, Baylin S, Zahnow C, Ahuja N, Davidson N, Stearns V. OT3-01-06: A Phase 2 Study Investigating the Safety, Efficacy and Surrogate Biomarkers of Response of 5-Azacitidine (5-AZA) and Entinostat (MS-275) in Patients with Advanced Breast Cancer. Cancer Research. 71. DOI: 10.1158/0008-5472.Sabcs11-Ot3-01-06  0.457
2010 Johnstone SE, Baylin SB. Stress and the epigenetic landscape: a link to the pathobiology of human diseases? Nature Reviews. Genetics. 11: 806-12. PMID 20921961 DOI: 10.1038/Nrg2881  0.309
2010 Ohm JE, Mali P, Van Neste L, Berman DM, Liang L, Pandiyan K, Briggs KJ, Zhang W, Argani P, Simons B, Yu W, Matsui W, Van Criekinge W, Rassool FV, Zambidis E, ... ... Baylin SB, et al. Cancer-related epigenome changes associated with reprogramming to induced pluripotent stem cells. Cancer Research. 70: 7662-73. PMID 20841480 DOI: 10.1158/0008-5472.Can-10-1361  0.839
2010 Zahnow CA, Baylin SB. Epigenetic networks and miRNAs in stem cells and cancer. Molecular Cell. 39: 661-3. PMID 20832717 DOI: 10.1016/J.Molcel.2010.08.036  0.346
2010 Easwaran HP, Van Neste L, Cope L, Sen S, Mohammad HP, Pageau GJ, Lawrence JB, Herman JG, Schuebel KE, Baylin SB. Aberrant silencing of cancer-related genes by CpG hypermethylation occurs independently of their spatial organization in the nucleus. Cancer Research. 70: 8015-24. PMID 20736368 DOI: 10.1158/0008-5472.Can-10-0765  0.596
2010 Licchesi JD, Van Neste L, Tiwari VK, Cope L, Lin X, Baylin SB, Herman JG. Transcriptional regulation of Wnt inhibitory factor-1 by Miz-1/c-Myc. Oncogene. 29: 5923-34. PMID 20697356 DOI: 10.1038/Onc.2010.322  0.448
2010 Noushmehr H, Weisenberger DJ, Diefes K, Phillips HS, Pujara K, Berman BP, Pan F, Pelloski CE, Sulman EP, Bhat KP, Verhaak RG, Hoadley KA, Hayes DN, Perou CM, Schmidt HK, ... ... Baylin SB, et al. Identification of a CpG island methylator phenotype that defines a distinct subgroup of glioma. Cancer Cell. 17: 510-22. PMID 20399149 DOI: 10.1016/J.Ccr.2010.03.017  0.414
2010 Bailey VJ, Zhang Y, Keeley BP, Yin C, Pelosky KL, Brock M, Baylin SB, Herman JG, Wang TH. Single-tube analysis of DNA methylation with silica superparamagnetic beads. Clinical Chemistry. 56: 1022-5. PMID 20360128 DOI: 10.1373/Clinchem.2009.140244  0.49
2010 Mali P, Chou BK, Yen J, Ye Z, Zou J, Dowey S, Brodsky RA, Ohm JE, Yu W, Baylin SB, Yusa K, Bradley A, Meyers DJ, Mukherjee C, Cole PA, et al. Butyrate greatly enhances derivation of human induced pluripotent stem cells by promoting epigenetic remodeling and the expression of pluripotency-associated genes. Stem Cells (Dayton, Ohio). 28: 713-20. PMID 20201064 DOI: 10.1002/Stem.402  0.479
2010 Zhang W, Zeng X, Briggs KJ, Beaty R, Simons B, Chiu Yen RW, Tyler MA, Tsai HC, Ye Y, Gesell GS, Herman JG, Baylin SB, Watkins DN. A potential tumor suppressor role for Hic1 in breast cancer through transcriptional repression of ephrin-A1. Oncogene. 29: 2467-76. PMID 20154726 DOI: 10.1038/Onc.2010.12  0.627
2010 Tiwari VK, Baylin SB. Mapping networks of protein-mediated physical interactions between chromatin elements. Current Protocols in Molecular Biology / Edited by Frederick M. Ausubel ... [Et Al.]. Unit 21.16.1-13. PMID 20069537 DOI: 10.1002/0471142727.Mb2116S89  0.31
2010 Bailey VJ, Keeley BP, Zhang Y, Ho YP, Easwaran H, Brock MV, Pelosky KL, Carraway HE, Baylin SB, Herman JG, Wang TH. Enzymatic incorporation of multiple dyes for increased sensitivity in QD-FRET sensing for DNA methylation detection. Chembiochem : a European Journal of Chemical Biology. 11: 71-4. PMID 19904794 DOI: 10.1002/Cbic.200900630  0.494
2010 Baylin SB. Epigenetic Regulation In Lymphoid Malignancies Blood. 116: SCI-28-SCI-28. DOI: 10.1182/Blood.V116.21.Sci-28.Sci-28  0.598
2010 Keeley BP, Bailey VJ, Yin C, Passlack K, Stark A, Carraway HE, Baylin SB, Herman JG, Wang T“. DNA methylation density analysis via fluorescent dye incorporation Clinical Cancer Research. 16. DOI: 10.1158/Diag-10-A9  0.471
2010 Wang T“, Zhang Y, Bailey V, Pelosky KL, Brock M, Baylin SB, James HG. Nanoparticle-enabled highly sensitive detection of DNA methylation in single tube Clinical Cancer Research. 16. DOI: 10.1158/Diag-10-A16  0.511
2010 Mohammad H, Zhang W, Selonick H, Leadem B, Zhang M, Hooker C, Watkins DN, Karim B, Huso D, Herman JG, Baylin SB. Abstract LB-92: Loss of a single Hic1 allele accelerates polyp formation in Apc mice Cancer Research. 70. DOI: 10.1158/1538-7445.Am10-Lb-92  0.466
2010 Tsai H, Neste LV, Li H, Cai Y, Robert C, Shin JJ, Pappou E, Yen R, Minn I, Ahuja N, Brock MV, Rassool FV, Jang Y, Sharkis SJ, Matsui W, ... ... Baylin SB, et al. Abstract LB-88: Transient exposure to low-dose decitabine and azacytidine reprograms cancer cells to produce a prolonged antitumor response Cancer Research. 70. DOI: 10.1158/1538-7445.Am10-Lb-88  0.503
2010 Akiyama Y, Nagasali H, Kawamoto A, Herman JG, Baylin SB, Yuasa Y. Abstract 200: Methylation of GATA4 and GATA5 transcription factor genes in gastric cancers Cancer Research. 70: 200-200. DOI: 10.1158/1538-7445.Am10-200  0.511
2010 Lin S, Zhou H, Kumar R, Herman J, DeWeese T, Iacobuzio-Donahue C, Baylin S. Reprimo-like is a P53 Responsive Gene Whose Promoter Methylation May Predict for Radiation Responsiveness in Pancreatic Cancer International Journal of Radiation Oncology*Biology*Physics. 78: S129. DOI: 10.1016/J.Ijrobp.2010.07.325  0.436
2009 Juergens RA, Vendetti F, Coleman B, Sebree RS, Rudek MA, Belinsky S, Brock M, Herman J, Baylin S, Rudin CM. Interim analysis of a phase II trial of 5-azacitidine (5AC) and entinostat (SNDX-275) in relapsed advanced lung cancer (NSCLC). Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology. 27: 8055. PMID 27962870 DOI: 10.1200/Jco.2009.27.15_Suppl.8055  0.493
2009 Tiwari VK, Baylin SB. Combined 3C-ChIP-cloning (6C) assay: a tool to unravel protein-mediated genome architecture. Cold Spring Harbor Protocols. 2009: pdb.prot5168. PMID 20147103 DOI: 10.1101/Pdb.Prot5168  0.328
2009 Huang Y, Stewart TM, Wu Y, Baylin SB, Marton LJ, Perkins B, Jones RJ, Woster PM, Casero RA. Novel oligoamine analogues inhibit lysine-specific demethylase 1 and induce reexpression of epigenetically silenced genes. Clinical Cancer Research : An Official Journal of the American Association For Cancer Research. 15: 7217-28. PMID 19934284 DOI: 10.1158/1078-0432.Ccr-09-1293  0.541
2009 Mohammad HP, Cai Y, McGarvey KM, Easwaran H, Van Neste L, Ohm JE, O'Hagan HM, Baylin SB. Polycomb CBX7 promotes initiation of heritable repression of genes frequently silenced with cancer-specific DNA hypermethylation. Cancer Research. 69: 6322-30. PMID 19602592 DOI: 10.1158/0008-5472.Can-09-0065  0.838
2009 Hellebrekers DM, Lentjes MH, van den Bosch SM, Melotte V, Wouters KA, Daenen KL, Smits KM, Akiyama Y, Yuasa Y, Sanduleanu S, Khalid-de Bakker CA, Jonkers D, Weijenberg MP, Louwagie J, van Criekinge W, ... ... Baylin SB, et al. GATA4 and GATA5 are potential tumor suppressors and biomarkers in colorectal cancer. Clinical Cancer Research : An Official Journal of the American Association For Cancer Research. 15: 3990-7. PMID 19509152 DOI: 10.1158/1078-0432.Ccr-09-0055  0.453
2009 Tiwari VK, Baylin SB. Breaching the boundaries that safeguard against repression. Molecular Cell. 34: 395-7. PMID 19481516 DOI: 10.1016/J.Molcel.2009.05.007  0.55
2009 Bailey VJ, Easwaran H, Zhang Y, Griffiths E, Belinsky SA, Herman JG, Baylin SB, Carraway HE, Wang TH. MS-qFRET: a quantum dot-based method for analysis of DNA methylation. Genome Research. 19: 1455-61. PMID 19443857 DOI: 10.1101/Gr.088831.108  0.47
2009 Tessema M, Yu YY, Stidley CA, Machida EO, Schuebel KE, Baylin SB, Belinsky SA. Concomitant promoter methylation of multiple genes in lung adenocarcinomas from current, former and never smokers. Carcinogenesis. 30: 1132-8. PMID 19435948 DOI: 10.1093/Carcin/Bgp114  0.549
2009 Glöckner SC, Dhir M, Yi JM, McGarvey KE, Van Neste L, Louwagie J, Chan TA, Kleeberger W, de Bruïne AP, Smits KM, Khalid-de Bakker CA, Jonkers DM, Stockbrügger RW, Meijer GA, Oort FA, ... ... Baylin SB, et al. Methylation of TFPI2 in stool DNA: a potential novel biomarker for the detection of colorectal cancer. Cancer Research. 69: 4691-9. PMID 19435926 DOI: 10.1158/0008-5472.Can-08-0142  0.5
2009 Zhang Y, Bailey V, Puleo CM, Easwaran H, Griffiths E, Herman JG, Baylin SB, Wang TH. DNA methylation analysis on a droplet-in-oil PCR array. Lab On a Chip. 9: 1059-64. PMID 19350087 DOI: 10.1039/B821780G  0.368
2009 Louwagie J, Pommerien W, Brichard G, Otto G, Van Criekinge W, Baylin S, Ahuja N, Adams H, Nürnberg D, Bierau K. 12LBA A Plasma-based colorectal cancer (CRC) screening assay using DNA methylation markers - first results of multicenter studies European Journal of Cancer Supplements. 7: 9. DOI: 10.1016/S1359-6349(09)72047-6  0.429
2009 Dhir M, Calmon MF, Jeschke J, Azad N, Herman J, Baylin SB, Ahuja N. W1755 Exploring Combination Epigenetic Therapy for the Treatment of Colorectal Cancer Gastroenterology. 136: A-934. DOI: 10.1016/S0016-5085(09)64324-9  0.377
2009 Dhir M, Glockner S, Neste LV, Schuebel K, Baylin S, Ahuja N. 55: Early Methylation of SYNE1 in Colorectal Cancer: Implications for Stool-Based Colorectal Cancer Screening Journal of Surgical Research. 151: 195-196. DOI: 10.1016/J.Jss.2008.11.065  0.409
2008 Tiwari VK, McGarvey KM, Licchesi JD, Ohm JE, Herman JG, Schübeler D, Baylin SB. PcG proteins, DNA methylation, and gene repression by chromatin looping. Plos Biology. 6: 2911-27. PMID 19053175 DOI: 10.1371/Journal.Pbio.0060306  0.842
2008 Yi JM, Tsai HC, Glöckner SC, Lin S, Ohm JE, Easwaran H, James CD, Costello JF, Riggins G, Eberhart CG, Laterra J, Vescovi AL, Ahuja N, Herman JG, Schuebel KE, ... Baylin SB, et al. Abnormal DNA methylation of CD133 in colorectal and glioblastoma tumors. Cancer Research. 68: 8094-103. PMID 18829568 DOI: 10.1158/0008-5472.Can-07-6208  0.524
2008 Dhir M, Montgomery EA, Glöckner SC, Schuebel KE, Hooker CM, Herman JG, Baylin SB, Gearhart SL, Ahuja N. Epigenetic regulation of WNT signaling pathway genes in inflammatory bowel disease (IBD) associated neoplasia. Journal of Gastrointestinal Surgery : Official Journal of the Society For Surgery of the Alimentary Tract. 12: 1745-53. PMID 18716850 DOI: 10.1007/S11605-008-0633-5  0.371
2008 O'Hagan HM, Mohammad HP, Baylin SB. Double strand breaks can initiate gene silencing and SIRT1-dependent onset of DNA methylation in an exogenous promoter CpG island. Plos Genetics. 4: e1000155. PMID 18704159 DOI: 10.1371/Journal.Pgen.1000155  0.563
2008 McGarvey KM, Van Neste L, Cope L, Ohm JE, Herman JG, Van Criekinge W, Schuebel KE, Baylin SB. Defining a chromatin pattern that characterizes DNA-hypermethylated genes in colon cancer cells. Cancer Research. 68: 5753-9. PMID 18632628 DOI: 10.1158/0008-5472.Can-08-0700  0.849
2008 Chan TA, Glockner S, Yi JM, Chen W, Van Neste L, Cope L, Herman JG, Velculescu V, Schuebel KE, Ahuja N, Baylin SB. Convergence of mutation and epigenetic alterations identifies common genes in cancer that predict for poor prognosis. Plos Medicine. 5: e114. PMID 18507500 DOI: 10.1371/Journal.Pmed.0050114  0.466
2008 Tiwari VK, Cope L, McGarvey KM, Ohm JE, Baylin SB. A novel 6C assay uncovers Polycomb-mediated higher order chromatin conformations. Genome Research. 18: 1171-9. PMID 18502945 DOI: 10.1101/Gr.073452.107  0.784
2008 Zhang W, Glöckner SC, Guo M, Machida EO, Wang DH, Easwaran H, Van Neste L, Herman JG, Schuebel KE, Watkins DN, Ahuja N, Baylin SB. Epigenetic inactivation of the canonical Wnt antagonist SRY-box containing gene 17 in colorectal cancer. Cancer Research. 68: 2764-72. PMID 18413743 DOI: 10.1158/0008-5472.Can-07-6349  0.525
2008 Ting AH, Suzuki H, Cope L, Schuebel KE, Lee BH, Toyota M, Imai K, Shinomura Y, Tokino T, Baylin SB. A requirement for DICER to maintain full promoter CpG island hypermethylation in human cancer cells. Cancer Research. 68: 2570-5. PMID 18413723 DOI: 10.1158/0008-5472.Can-07-6405  0.816
2008 Briggs KJ, Corcoran-Schwartz IM, Zhang W, Harcke T, Devereux WL, Baylin SB, Eberhart CG, Watkins DN. Cooperation between the Hic1 and Ptch1 tumor suppressors in medulloblastoma. Genes & Development. 22: 770-85. PMID 18347096 DOI: 10.1101/Gad.1640908  0.419
2008 Tessema M, Willink R, Do K, Yu YY, Yu W, Machida EO, Brock M, Van Neste L, Stidley CA, Baylin SB, Belinsky SA. Promoter methylation of genes in and around the candidate lung cancer susceptibility locus 6q23-25. Cancer Research. 68: 1707-14. PMID 18339850 DOI: 10.1158/0008-5472.Can-07-6325  0.515
2008 Brock MV, Hooker CM, Ota-Machida E, Han Y, Guo M, Ames S, Glöckner S, Piantadosi S, Gabrielson E, Pridham G, Pelosky K, Belinsky SA, Yang SC, Baylin SB, Herman JG. DNA methylation markers and early recurrence in stage I lung cancer. The New England Journal of Medicine. 358: 1118-28. PMID 18337602 DOI: 10.1056/Nejmoa0706550  0.464
2008 Licchesi JD, Westra WH, Hooker CM, Machida EO, Baylin SB, Herman JG. Epigenetic alteration of Wnt pathway antagonists in progressive glandular neoplasia of the lung. Carcinogenesis. 29: 895-904. PMID 18308762 DOI: 10.1093/Carcin/Bgn017  0.309
2008 Suzuki H, Toyota M, Carraway H, Caraway H, Gabrielson E, Ohmura T, Fujikane T, Nishikawa N, Sogabe Y, Nojima M, Sonoda T, Mori M, Hirata K, Imai K, Shinomura Y, ... Baylin SB, et al. Frequent epigenetic inactivation of Wnt antagonist genes in breast cancer. British Journal of Cancer. 98: 1147-56. PMID 18283316 DOI: 10.1038/Sj.Bjc.6604259  0.451
2008 Jiemjit A, Fandy TE, Carraway H, Bailey KA, Baylin S, Herman JG, Gore SD. p21WAF1/CIP1 induction by 5-azacytosine nucleosides requires DNA damage Oncogene. 27: 3615-3623. PMID 18223691 DOI: 10.1038/Sj.Onc.1211018  0.445
2008 Winter JM, Ting AH, Vilardell F, Gallmeier E, Baylin SB, Hruban RH, Kern SE, Iacobuzio-Donahue CA. Absence of E-cadherin expression distinguishes noncohesive from cohesive pancreatic cancer Clinical Cancer Research. 14: 412-418. PMID 18223216 DOI: 10.1158/1078-0432.CCR-07-0487  0.663
2008 Juergens RA, Vendetti F, Coleman B, Sebree RS, Rudek MA, Belinsky SA, Brock MV, Herman JG, Baylin SB, Rudin CM. Phase I trial of 5-azacitidine (5AC) and SNDX-275 in advanced lung cancer (NSCLC) Journal of Clinical Oncology. 26: 19036-19036. DOI: 10.1200/Jco.2008.26.15_Suppl.19036  0.431
2008 Suzuki H, Toyota M, Carraway H, Gabrielson E, Ohmura T, Fujikane T, Nishikawa N, Sogabe Y, Nojima M, Sonoda T, Mori M, Hirata K, Imai K, Shinomura Y, Baylin SB, et al. Frequent epigenetic inactivation of Wnt antagonist genes in breast cancer (British Journal of Cancer (2008) 98, (1147-1156) DOI: 10.1038/sj.bjc.6604259) British Journal of Cancer. 99: 384. DOI: 10.1038/Sj.Bjc.6604507  0.438
2008 Ahuja N, Schuebel K, Glockner S, Dhir M, Van Neste L, Yi J, Herman J, Baylin S. 42. Utilization of Genomic Approaches to Identify the Hypermethylome of Colorectal Cancer - A Strategy for Biomarker Discovery Journal of Surgical Research. 144: 194. DOI: 10.1016/J.Jss.2007.12.049  0.318
2008 Rimner A, Ho A, Ahuja N, Schuebel K, Baylin S, Gerald W, Chan T. Syne1 Promoter Hypermethylation as a Predictor of Tumor Aggressiveness in Primary Breast Cancer International Journal of Radiation Oncology*Biology*Physics. 72: S681-S682. DOI: 10.1016/J.Ijrobp.2008.06.563  0.369
2007 Riojas MA, Guo M, Glöckner SC, Machida EO, Baylin SB, Ahuja N. Methylation-induced silencing of ASC/TMS1, a pro-apoptotic gene, is a late-stage event in colorectal cancer. Cancer Biology & Therapy. 6: 1710-6. PMID 17986858 DOI: 10.4161/Cbt.6.11.4829  0.529
2007 Schuebel KE, Chen W, Cope L, Glöckner SC, Suzuki H, Yi JM, Chan TA, Van Neste L, Van Criekinge W, van den Bosch S, van Engeland M, Ting AH, Jair K, Yu W, Toyota M, ... ... Baylin SB, et al. Comparing the DNA hypermethylome with gene mutations in human colorectal cancer. Plos Genetics. 3: 1709-23. PMID 17892325 DOI: 10.1371/Journal.Pgen.0030157  0.794
2007 McGarvey KM, Greene E, Fahrner JA, Jenuwein T, Baylin SB. DNA methylation and complete transcriptional silencing of cancer genes persist after depletion of EZH2. Cancer Research. 67: 5097-102. PMID 17545586 DOI: 10.1158/0008-5472.Can-06-2029  0.857
2007 Brock MV, Herman JG, Baylin SB. Cancer as a manifestation of aberrant chromatin structure. Cancer Journal (Sudbury, Mass.). 13: 3-8. PMID 17464240 DOI: 10.1097/PPO.0b013e31803c5415  0.473
2007 Huang Y, Greene E, Murray Stewart T, Goodwin AC, Baylin SB, Woster PM, Casero RA. Inhibition of lysine-specific demethylase 1 by polyamine analogues results in reexpression of aberrantly silenced genes. Proceedings of the National Academy of Sciences of the United States of America. 104: 8023-8. PMID 17463086 DOI: 10.1073/Pnas.0700720104  0.54
2007 Ohm JE, Baylin SB. Stem cell chromatin patterns: an instructive mechanism for DNA hypermethylation? Cell Cycle (Georgetown, Tex.). 6: 1040-3. PMID 17457052 DOI: 10.4161/Cc.6.9.4210  0.567
2007 Jones PA, Baylin SB. The epigenomics of cancer. Cell. 128: 683-92. PMID 17320506 DOI: 10.1016/J.Cell.2007.01.029  0.486
2007 Ohm JE, McGarvey KM, Yu X, Cheng L, Schuebel KE, Cope L, Mohammad HP, Chen W, Daniel VC, Yu W, Berman DM, Jenuwein T, Pruitt K, Sharkis SJ, Watkins DN, ... ... Baylin SB, et al. A stem cell-like chromatin pattern may predispose tumor suppressor genes to DNA hypermethylation and heritable silencing. Nature Genetics. 39: 237-42. PMID 17211412 DOI: 10.1038/Ng1972  0.862
2007 Zinn RL, Pruitt K, Eguchi S, Baylin SB, Herman JG. hTERT is expressed in cancer cell lines despite promoter DNA methylation by preservation of unmethylated DNA and active chromatin around the transcription start site. Cancer Research. 67: 194-201. PMID 17210699 DOI: 10.1158/0008-5472.Can-06-3396  0.858
2007 Machida EO, Brock MV, Hooker CM, Nakayama J, Ishida A, Amano J, Picchi M, Belinsky SA, Herman JG, Taniguchi S, Baylin SB. Erratum: Hypermethylation of ASC/TMS1 is a sputum marker for late-stage lung cancer (Cancer Research (June 15, 2006) 66 (6210-6218)) Cancer Research. 67. DOI: 10.1158/0008-5472.Can-67-1-Cor  0.343
2007 Ahuja N, Baylin SB. Subclassifcation of microsatellite-unstable tumors in colorectal cancer Current Colorectal Cancer Reports. 3: 212-219. DOI: 10.1007/S11888-007-0033-3  0.414
2006 Ting AH, McGarvey KM, Baylin SB. The cancer epigenome--components and functional correlates. Genes & Development. 20: 3215-31. PMID 17158741 DOI: 10.1101/Gad.1464906  0.851
2006 Singh A, Misra V, Thimmulappa RK, Lee H, Ames S, Hoque MO, Herman JG, Baylin SB, Sidransky D, Gabrielson E, Brock MV, Biswal S. Dysfunctional KEAP1-NRF2 interaction in non-small-cell lung cancer. Plos Medicine. 3: e420. PMID 17020408 DOI: 10.1371/Journal.Pmed.0030420  0.385
2006 Baylin SB, Chen WY. Aberrant gene silencing in tumor progression: implications for control of cancer. Cold Spring Harbor Symposia On Quantitative Biology. 70: 427-33. PMID 16869780 DOI: 10.1101/SQB.2005.70.010  0.457
2006 Guo M, House MG, Akiyama Y, Qi Y, Capagna D, Harmon J, Baylin SB, Brock MV, Herman JG. Hypermethylation of the GATA gene family in esophageal cancer. International Journal of Cancer. Journal International Du Cancer. 119: 2078-83. PMID 16823849 DOI: 10.1002/Ijc.22092  0.556
2006 Schuebel K, Chen W, Baylin SB. CIMPle origin for promoter hypermethylation in colorectal cancer? Nature Genetics. 38: 738-40. PMID 16804535 DOI: 10.1038/Ng0706-738  0.539
2006 Gore SD, Baylin S, Sugar E, Carraway H, Miller CB, Carducci M, Grever M, Galm O, Dauses T, Karp JE, Rudek MA, Zhao M, Smith BD, Manning J, Jiemjit A, et al. Combined DNA methyltransferase and histone deacetylase inhibition in the treatment of myeloid neoplasms. Cancer Research. 66: 6361-9. PMID 16778214 DOI: 10.1158/0008-5472.Can-06-0080  0.516
2006 Machida EO, Brock MV, Hooker CM, Nakayama J, Ishida A, Amano J, Picchi MA, Belinsky SA, Herman JG, Taniguchi S, Baylin SB. Hypermethylation of ASC/TMS1 is a sputum marker for late-stage lung cancer. Cancer Research. 66: 6210-8. PMID 16778195 DOI: 10.1158/0008-5472.Can-05-4447  0.411
2006 Pruitt K, Zinn RL, Ohm JE, McGarvey KM, Kang SH, Watkins DN, Herman JG, Baylin SB. Inhibition of SIRT1 reactivates silenced cancer genes without loss of promoter DNA hypermethylation. Plos Genetics. 2: e40. PMID 16596166 DOI: 10.1371/Journal.Pgen.0020040  0.855
2006 McGarvey KM, Fahrner JA, Greene E, Martens J, Jenuwein T, Baylin SB. Silenced tumor suppressor genes reactivated by DNA demethylation do not return to a fully euchromatic chromatin state. Cancer Research. 66: 3541-9. PMID 16585178 DOI: 10.1158/0008-5472.Can-05-2481  0.858
2006 Belinsky SA, Liechty KC, Gentry FD, Wolf HJ, Rogers J, Vu K, Haney J, Kennedy TC, Hirsch FR, Miller Y, Franklin WA, Herman JG, Baylin SB, Bunn PA, Byers T. Promoter hypermethylation of multiple genes in sputum precedes lung cancer incidence in a high-risk cohort. Cancer Research. 66: 3338-44. PMID 16540689 DOI: 10.1158/0008-5472.Can-05-3408  0.463
2006 Hellebrekers DM, Jair KW, Viré E, Eguchi S, Hoebers NT, Fraga MF, Esteller M, Fuks F, Baylin SB, van Engeland M, Griffioen AW. Angiostatic activity of DNA methyltransferase inhibitors. Molecular Cancer Therapeutics. 5: 467-75. PMID 16505122 DOI: 10.1158/1535-7163.Mct-05-0417  0.803
2006 Baylin SB, Ohm JE. Epigenetic gene silencing in cancer - a mechanism for early oncogenic pathway addiction? Nature Reviews. Cancer. 6: 107-16. PMID 16491070 DOI: 10.1038/Nrc1799  0.553
2006 Galm O, Herman JG, Baylin SB. The fundamental role of epigenetics in hematopoietic malignancies. Blood Reviews. 20: 1-13. PMID 16426940 DOI: 10.1016/J.Blre.2005.01.006  0.62
2006 Ting AH, Jair KW, Schuebel KE, Baylin SB. Differential requirement for DNA methyltransferase 1 in maintaining human cancer cell gene promoter hypermethylation. Cancer Research. 66: 729-35. PMID 16424002 DOI: 10.1158/0008-5472.Can-05-1537  0.801
2006 Jair KW, Bachman KE, Suzuki H, Ting AH, Rhee I, Yen RW, Baylin SB, Schuebel KE. De novo CpG island methylation in human cancer cells. Cancer Research. 66: 682-92. PMID 16423997 DOI: 10.1158/0008-5472.Can-05-1980  0.858
2006 Wen XZ, Akiyama Y, Baylin SB, Yuasa Y. Frequent epigenetic silencing of the bone morphogenetic protein 2 gene through methylation in gastric carcinomas. Oncogene. 25: 2666-73. PMID 16314833 DOI: 10.1038/Sj.Onc.1209297  0.477
2005 Baylin SB. DNA methylation and gene silencing in cancer. Nature Clinical Practice. Oncology. 2: S4-11. PMID 16341240 DOI: 10.1038/Ncponc0354  0.63
2005 Chen WY, Wang DH, Yen RC, Luo J, Gu W, Baylin SB. Tumor suppressor HIC1 directly regulates SIRT1 to modulate p53-dependent DNA-damage responses. Cell. 123: 437-48. PMID 16269335 DOI: 10.1016/J.Cell.2005.08.011  0.502
2005 Brock MV, Hooker CM, Yung R, Guo M, Han Y, Ames SE, Chang D, Yang SC, Mason D, Sussman M, Baylin SB, Herman JG. Can we improve the cytologic examination of malignant pleural effusions using molecular analysis? The Annals of Thoracic Surgery. 80: 1241-7. PMID 16181847 DOI: 10.1016/J.Athoracsur.2005.05.088  0.44
2005 Schuebel K, Baylin SB. In living color: DNA methyltransferase caught in the act Nature Methods. 2: 736-738. PMID 16179918 DOI: 10.1038/Nmeth1005-736  0.338
2005 Ting AH, Schuebel KE, Herman JG, Baylin SB. Short double-stranded RNA induces transcriptional gene silencing in human cancer cells in the absence of DNA methylation. Nature Genetics. 37: 906-10. PMID 16025112 DOI: 10.1038/Ng1611  0.811
2005 Galm O, Suzuki H, Akiyama Y, Esteller M, Brock MV, Osieka R, Baylin SB, Herman JG. Inactivation of the tissue inhibitor of metalloproteinases-2 gene by promoter hypermethylation in lymphoid malignancies. Oncogene. 24: 4799-805. PMID 15870703 DOI: 10.1038/Sj.Onc.1208599  0.445
2005 Brock MV, Hooker CM, Syphard JE, Westra W, Xu L, Alberg AJ, Mason D, Baylin SB, Herman JG, Yung RC, Brahmer J, Rudin CM, Ettinger DS, Yang SC. Surgical resection of limited disease small cell lung cancer in the new era of platinum chemotherapy: Its time has come. The Journal of Thoracic and Cardiovascular Surgery. 129: 64-72. PMID 15632826 DOI: 10.1016/J.Jtcvs.2004.08.022  0.318
2005 Chen WY, Baylin SB. Inactivation of tumor suppressor genes: choice between genetic and epigenetic routes. Cell Cycle (Georgetown, Tex.). 4: 10-2. PMID 15611624 DOI: 10.4161/Cc.4.1.1361  0.485
2004 Guo M, Akiyama Y, House MG, Hooker CM, Heath E, Gabrielson E, Yang SC, Han Y, Baylin SB, Herman JG, Brock MV. Hypermethylation of the GATA genes in lung cancer. Clinical Cancer Research : An Official Journal of the American Association For Cancer Research. 10: 7917-24. PMID 15585625 DOI: 10.1158/1078-0432.Ccr-04-1140  0.436
2004 Chen W, Cooper TK, Zahnow CA, Overholtzer M, Zhao Z, Ladanyi M, Karp JE, Gokgoz N, Wunder JS, Andrulis IL, Levine AJ, Mankowski JL, Baylin SB. Epigenetic and genetic loss of Hic1 function accentuates the role of p53 in tumorigenesis. Cancer Cell. 6: 387-98. PMID 15488761 DOI: 10.1016/J.Ccr.2004.08.030  0.478
2004 Guo M, House MG, Hooker C, Han Y, Heath E, Gabrielson E, Yang SC, Baylin SB, Herman JG, Brock MV. Promoter hypermethylation of resected bronchial margins: a field defect of changes? Clinical Cancer Research : An Official Journal of the American Association For Cancer Research. 10: 5131-6. PMID 15297416 DOI: 10.1158/1078-0432.Ccr-03-0763  0.422
2004 Ting AH, Jair KW, Suzuki H, Yen RW, Baylin SB, Schuebel KE. Mammalian DNA methyltransferase 1: inspiration for new directions. Cell Cycle (Georgetown, Tex.). 3: 1024-6. PMID 15280656 DOI: 10.4161/Cc.3.8.1070  0.756
2004 Baylin SB. Reversal of gene silencing as a therapeutic target for cancer--roles for DNA methylation and its interdigitation with chromatin. Novartis Foundation Symposium. 259: 226-33; discussion 2. PMID 15171257  0.53
2004 Ting AH, Jair KW, Suzuki H, Yen RW, Baylin SB, Schuebel KE. CpG island hypermethylation is maintained in human colorectal cancer cells after RNAi-mediated depletion of DNMT1. Nature Genetics. 36: 582-4. PMID 15156141 DOI: 10.1038/Ng1365  0.777
2004 Suzuki H, Watkins DN, Jair KW, Schuebel KE, Markowitz SD, Chen WD, Pretlow TP, Yang B, Akiyama Y, Van Engeland M, Toyota M, Tokino T, Hinoda Y, Imai K, Herman JG, ... Baylin SB, et al. Epigenetic inactivation of SFRP genes allows constitutive WNT signaling in colorectal cancer. Nature Genetics. 36: 417-22. PMID 15034581 DOI: 10.1038/Ng1330  0.4
2004 Douglas DB, Akiyama Y, Carraway H, Belinsky SA, Esteller M, Gabrielson E, Weitzman S, Williams T, Herman JG, Baylin SB. Hypermethylation of a small CpGuanine-rich region correlates with loss of activator protein-2alpha expression during progression of breast cancer. Cancer Research. 64: 1611-20. PMID 14996719 DOI: 10.1158/0008-5472.Can-0318-2  0.417
2004 Kirk J, Herman JG, Baylin SB. Gene Silencing [4] (multiple letters) The New England Journal of Medicine. 350: 947-948. PMID 14985497 DOI: 10.1056/Nejm200402263500920  0.375
2004 Stoehr R, Wissmann C, Suzuki H, Knuechel R, Krieg RC, Klopocki E, Dahl E, Wild P, Blaszyk H, Sauter G, Simon R, Schmitt R, Zaak D, Hofstaedter F, Rosenthal A, ... Baylin SB, et al. Deletions of chromosome 8p and loss of sFRP1 expression are progression markers of papillary bladder cancer. Laboratory Investigation; a Journal of Technical Methods and Pathology. 84: 465-78. PMID 14968126 DOI: 10.1038/Labinvest.3700068  0.437
2004 Gore SD, Baylin SB, Dauses T, Grever MR, Jiemjit A, Manning J, Miller CB, Murgo AJ, Zwiebel JA, Herman JG. Changes in Promoter Methylation and Gene Expression in Patients with MDS and MDS-AML Treated with 5-Azacitidine and Sodium Phenylbutyrate. Blood. 104: 469-469. DOI: 10.1182/Blood.V104.11.469.469  0.447
2004 Baylin SB. Reversal of gene silencing as a therapeutic target for cancer--roles for DNA methylation and its interdigitation with chromatin. Novartis Foundation Symposium. 259: 226-237. DOI: 10.1002/0470862637.Ch17  0.608
2003 Herman JG, Baylin SB. Gene silencing in cancer in association with promoter hypermethylation. The New England Journal of Medicine. 349: 2042-54. PMID 14627790 DOI: 10.1056/Nejmra023075  0.502
2003 Belinsky SA, Klinge DM, Stidley CA, Issa JP, Herman JG, March TH, Baylin SB. Inhibition of DNA methylation and histone deacetylation prevents murine lung cancer. Cancer Research. 63: 7089-93. PMID 14612500  0.458
2003 Akiyama Y, Watkins N, Suzuki H, Jair KW, van Engeland M, Esteller M, Sakai H, Ren CY, Yuasa Y, Herman JG, Baylin SB. GATA-4 and GATA-5 transcription factor genes and potential downstream antitumor target genes are epigenetically silenced in colorectal and gastric cancer. Molecular and Cellular Biology. 23: 8429-39. PMID 14612389 DOI: 10.1128/Mcb.23.23.8429-8439.2003  0.538
2003 Brock MV, Gou M, Akiyama Y, Muller A, Wu TT, Montgomery E, Deasel M, Germonpré P, Rubinson L, Heitmiller RF, Yang SC, Forastiere AA, Baylin SB, Herman JG. Prognostic importance of promoter hypermethylation of multiple genes in esophageal adenocarcinoma. Clinical Cancer Research : An Official Journal of the American Association For Cancer Research. 9: 2912-9. PMID 12912936  0.324
2003 Palmisano WA, Crume KP, Grimes MJ, Winters SA, Toyota M, Esteller M, Joste N, Baylin SB, Belinsky SA. Aberrant promoter methylation of the transcription factor genes PAX5 alpha and beta in human cancers. Cancer Research. 63: 4620-5. PMID 12907641  0.457
2003 Fahrner JA, Baylin SB. Heterochromatin: stable and unstable invasions at home and abroad. Genes & Development. 17: 1805-12. PMID 12897049 DOI: 10.1101/Gad.1123303  0.755
2003 Reese BE, Bachman KE, Baylin SB, Rountree MR. The methyl-CpG binding protein MBD1 interacts with the p150 subunit of chromatin assembly factor 1. Molecular and Cellular Biology. 23: 3226-36. PMID 12697822 DOI: 10.1128/Mcb.23.9.3226-3236.2003  0.744
2003 Watkins DN, Berman DM, Burkholder SG, Wang B, Beachy PA, Baylin SB. Hedgehog signalling within airway epithelial progenitors and in small-cell lung cancer. Nature. 422: 313-7. PMID 12629553 DOI: 10.1038/Nature01493  0.326
2003 Bachman KE, Park BH, Rhee I, Rajagopalan H, Herman JG, Baylin SB, Kinzler KW, Vogelstein B. Histone modifications and silencing prior to DNA methylation of a tumor suppressor gene Cancer Cell. 3: 89-95. PMID 12559178 DOI: 10.1016/S1535-6108(02)00234-9  0.783
2003 Chen WY, Zeng X, Carter MG, Morrell CN, Chiu Yen RW, Esteller M, Watkins DN, Herman JG, Mankowski JL, Baylin SB. Heterozygous disruption of Hic1 predisposes mice to a gender-dependent spectrum of malignant tumors. Nature Genetics. 33: 197-202. PMID 12539045 DOI: 10.1038/Ng1077  0.788
2003 Baylin SB. Mechanisms underlying epigenetically mediated gene silencing in cancer. Seminars in Cancer Biology. 12: 331-7. PMID 12191632 DOI: 10.1016/S1044-579X(02)00053-6  0.549
2003 Watkins DN, Berman DM, Baylin SB. Hedgehog Signaling: Progenitor Phenotype in Small-Cell Lung Cancer Cell Cycle. 2: 195-197. DOI: 10.4161/Cc.2.3.378  0.372
2002 Fahrner JA, Eguchi S, Herman JG, Baylin SB. Dependence of histone modifications and gene expression on DNA hypermethylation in cancer. Cancer Research. 62: 7213-8. PMID 12499261  0.848
2002 Esteller M, Guo M, Moreno V, Peinado MA, Capella G, Galm O, Baylin SB, Herman JG. Hypermethylation-associated Inactivation of the Cellular Retinol-Binding-Protein 1 Gene in Human Cancer. Cancer Research. 62: 5902-5. PMID 12384555  0.409
2002 Cameron E, Mijovic A, Herman JG, Baylin SB, Pradhan A, Mufti GJ, Rassool FV. P15INK4B is not mutated in adult familial myelodysplastic syndromes. British Journal of Haematology. 119: 277-9. PMID 12358941 DOI: 10.1046/J.1365-2141.2002.37707.X  0.716
2002 Baylin S, Bestor TH. Altered methylation patterns in cancer cell genomes: cause or consequence? Cancer Cell. 1: 299-305. PMID 12086841 DOI: 10.1016/S1535-6108(02)00061-2  0.555
2002 Jones PA, Baylin SB. The fundamental role of epigenetic events in cancer. Nature Reviews. Genetics. 3: 415-28. PMID 12042769 DOI: 10.1038/Nrg816  0.591
2002 Suzuki H, Gabrielson E, Chen W, Anbazhagan R, van Engeland M, Weijenberg MP, Herman JG, Baylin SB. A genomic screen for genes upregulated by demethylation and histone deacetylase inhibition in human colorectal cancer. Nature Genetics. 31: 141-9. PMID 11992124 DOI: 10.1038/Ng892  0.549
2002 Rhee I, Bachman KE, Park BH, Jair KW, Yen RW, Schuebel KE, Cui H, Feinberg AP, Lengauer C, Kinzler KW, Baylin SB, Vogelstein B. DNMT1 and DNMT3b cooperate to silence genes in human cancer cells. Nature. 416: 552-6. PMID 11932749 DOI: 10.1038/416552A  0.801
2002 Galm O, Rountree MR, Bachman KE, Jair KW, Baylin SB, Herman JG. Enzymatic regional methylation assay: a novel method to quantify regional CpG methylation density. Genome Research. 12: 153-7. PMID 11779840 DOI: 10.1101/Gr.202501  0.742
2002 Esteller M, Gaidano G, Goodman SN, Zagonel V, Capello D, Botto B, Rossi D, Gloghini A, Vitolo U, Carbone A, Baylin SB, Herman JG. Hypermethylation of the DNA repair gene O(6)-methylguanine DNA methyltransferase and survival of patients with diffuse large B-cell lymphoma. Journal of the National Cancer Institute. 94: 26-32. PMID 11773279 DOI: 10.1093/Jnci/94.1.26  0.453
2001 Herman JG, Baylin SB. Methylation-specific PCR. Current Protocols in Human Genetics. 16: 305-323. PMID 18428243 DOI: 10.1002/0471142905.Hg1006S16  0.493
2001 Esteller M, Fraga MF, Guo M, Garcia-Foncillas J, Hedenfalk I, Godwin AK, Trojan J, Vaurs-Barrière C, Bignon YJ, Ramus S, Benitez J, Caldes T, Akiyama Y, Yuasa Y, Launonen V, ... ... Baylin SB, et al. DNA methylation patterns in hereditary human cancers mimic sporadic tumorigenesis Human Molecular Genetics. 10: 3001-3007. PMID 11751682 DOI: 10.1093/Hmg/10.26.3001  0.595
2001 Bachman KE, Rountree MR, Baylin SB. Dnmt3a and Dnmt3b are transcriptional repressors that exhibit unique localization properties to heterochromatin. The Journal of Biological Chemistry. 276: 32282-7. PMID 11427539 DOI: 10.1074/Jbc.M104661200  0.742
2001 Rountree MR, Bachman KE, Herman JG, Baylin SB. DNA methylation, chromatin inheritance, and cancer. Oncogene. 20: 3156-65. PMID 11420732 DOI: 10.1038/Sj.Onc.1204339  0.806
2001 Baylin SB, Herman JG. Promoter hypermethylation--can this change alone ever designate true tumor suppressor gene function? Journal of the National Cancer Institute. 93: 664-5. PMID 11333278 DOI: 10.1093/Jnci/93.9.664  0.389
2001 Sriuranpong V, Borges MW, Ravi RK, Arnold DR, Nelkin BD, Baylin SB, Ball DW. Notch signaling induces cell cycle arrest in small cell lung cancer cells. Cancer Research. 61: 3200-5. PMID 11306509  0.59
2001 Baylin SB, Esteller M, Rountree MR, Bachman KE, Schuebel K, Herman JG. Aberrant patterns of DNA methylation, chromatin formation and gene expression in cancer. Human Molecular Genetics. 10: 687-92. PMID 11257100 DOI: 10.1093/Hmg/10.7.687  0.811
2001 Myöhänen S, Baylin SB. Sequence-specific DNA binding activity of RNA helicase A to the p16INK4a promoter. The Journal of Biological Chemistry. 276: 1634-42. PMID 11038348 DOI: 10.1074/Jbc.M004481200  0.462
2000 Esteller M, Garcia-Foncillas J, Andion E, Goodman SN, Hidalgo OF, Vanaclocha V, Baylin SB, Herman JG. Inactivation of the DNA-repair gene MGMT and the clinical response of gliomas to alkylating agents. The New England Journal of Medicine. 343: 1350-4. PMID 11070098 DOI: 10.1056/Nejm200011093431901  0.533
2000 Baylin SB, Belinsky SA, Herman JG. Aberrant methylation of gene promoters in cancer - Concepts, misconcepts, and promise Journal of the National Cancer Institute. 92: 1460-1461. PMID 10995795 DOI: 10.1093/Jnci/92.18.1460  0.569
2000 Rountree MR, Bachman KE, Baylin SB. DNMT1 binds HDAC2 and a new co-repressor, DMAP1, to form a complex at replication foci. Nature Genetics. 25: 269-77. PMID 10888872 DOI: 10.1038/77023  0.748
2000 Krasner A, Wallace L, Thiagalingam A, Jones C, Lengauer C, Minahan L, Ma Y, Kalikin L, Feinberg AP, Jabs EW, Tunnacliffe A, Baylin SB, Ball DW, Nelkin BD. Cloning and chromosomal localization of the human BARX2 homeobox protein gene. Gene. 250: 171-80. PMID 10854790 DOI: 10.1016/S0378-1119(00)00169-4  0.335
2000 Herman JG, Baylin SB. Promoter-region hypermethylation and gene silencing in human cancer. Current Topics in Microbiology and Immunology. 249: 35-54. PMID 10802937 DOI: 10.1007/978-3-642-59696-4_3  0.434
2000 Rhee I, Jair KW, Yen RW, Lengauer C, Herman JG, Kinzler KW, Vogelstein B, Baylin SB, Schuebel KE. CpG methylation is maintained in human cancer cells lacking DNMT1. Nature. 404: 1003-7. PMID 10801130 DOI: 10.1038/35010000  0.566
2000 Antoun G, Baylin SB, Ali-Osman F. DNA methyltransferase levels and altered CpG methylation in the total genome and in the GSTP1 gene in human glioma cells transfected with sense and antisense DNA methyltransferase cDNA. Journal of Cellular Biochemistry. 77: 372-81. PMID 10760946 DOI: 10.1002/(Sici)1097-4644(20000601)77:3<372::Aid-Jcb3>3.0.Co;2-P  0.548
2000 Esteller M, Silva JM, Dominguez G, Bonilla F, Matias-Guiu X, Lerma E, Bussaglia E, Prat J, Harkes IC, Repasky EA, Gabrielson E, Schutte M, Baylin SB, Herman JG. Promoter hypermethylation and BRCA1 inactivation in sporadic breast and ovarian tumors. Journal of the National Cancer Institute. 92: 564-9. PMID 10749912 DOI: 10.1093/Jnci/92.7.564  0.378
2000 Baylin SB, Herman JG. DNA hypermethylation in tumorigenesis: epigenetics joins genetics. Trends in Genetics : Tig. 16: 168-74. PMID 10729832 DOI: 10.1016/S0168-9525(99)01971-X  0.59
2000 Carter MG, Johns MA, Zeng X, Zhou L, Zink MC, Mankowski JL, Donovan DM, Baylin SB. Mice deficient in the candidate tumor suppressor gene Hic1 exhibit developmental defects of structures affected in the Miller-Dieker syndrome. Human Molecular Genetics. 9: 413-9. PMID 10655551 DOI: 10.1093/Hmg/9.3.413  0.75
2000 Eng C, Herman JG, Baylin SB. A bird's eye view of global methylation. Nature Genetics. 24: 101-2. PMID 10655046 DOI: 10.1038/72730  0.459
2000 Esteller M, Avizienyte E, Corn PG, Lothe RA, Baylin SB, Aaltonen LA, Herman JG. Epigenetic inactivation of LKB1 in primary tumors associated with the Peutz-Jeghers syndrome. Oncogene. 19: 164-8. PMID 10644993 DOI: 10.1038/Sj.Onc.1203227  0.507
2000 Graff JR, Gabrielson E, Fujii H, Baylin SB, Herman JG. Methylation patterns of the E-cadherin 5' CpG island are unstable and reflect the dynamic, heterogeneous loss of E-cadherin expression during metastatic progression Journal of Biological Chemistry. 275: 2727-2732. PMID 10644736 DOI: 10.1074/Jbc.275.4.2727  0.44
2000 Esteller M, Baylin SB, Herman JG. Beyond the genetic lesions: Gene inactivation by promoter hypermethylation in human cancer Clinical & Translational Oncology. 2: 61-66. DOI: 10.1007/Bf02979467  0.567
1999 Esteller M, Catasus L, Matias-Guiu X, Mutter GL, Prat J, Baylin SB, Herman JG. hMLH1 promoter hypermethylation is an early event in human endometrial tumorigenesis. The American Journal of Pathology. 155: 1767-72. PMID 10550333 DOI: 10.1016/S0002-9440(10)65492-2  0.345
1999 Nuovo GJ, Plaia TW, Belinsky SA, Baylin SB, Herman JG. In situ detection of the hypermethylation-induced inactivation of the p16 gene as an early event in oncogenesis Proceedings of the National Academy of Sciences of the United States of America. 96: 12754-12759. PMID 10535995 DOI: 10.1073/Pnas.96.22.12754  0.476
1999 Cameron EE, Baylin SB, Herman JG. p15(INK4B) CpG island methylation in primary acute leukemia is heterogeneous and suggests density as a critical factor for transcriptional silencing. Blood. 94: 2445-51. PMID 10498617 DOI: 10.1182/Blood.V94.7.2445.419K19_2445_2451  0.81
1999 Toyota M, Ahuja N, Ohe-Toyota M, Herman JG, Baylin SB, Issa JP. CpG island methylator phenotype in colorectal cancer. Proceedings of the National Academy of Sciences of the United States of America. 96: 8681-6. PMID 10411935 DOI: 10.1073/Pnas.96.15.8681  0.547
1999 McGregor LM, McCune BK, Graff JR, McDowell PR, Romans KE, Yancopoulos GD, Ball DW, Baylin SB, Nelkin BD. Roles of trk family neurotrophin receptors in medullary thyroid carcinoma development and progression. Proceedings of the National Academy of Sciences of the United States of America. 96: 4540-5. PMID 10200298 DOI: 10.1073/Pnas.96.8.4540  0.329
1999 Bachman KE, Herman JG, Corn PG, Merlo A, Costello JF, Cavenee WK, Baylin SB, Graff JR. Methylation-associated silencing of the tissue inhibitor of metalloproteinase-3 gene suggest a suppressor role in kidney, brain, and other human cancers. Cancer Research. 59: 798-802. PMID 10029065  0.736
1999 Cameron EE, Bachman KE, Myöhänen S, Herman JG, Baylin SB. Synergy of demethylation and histone deacetylase inhibition in the re-expression of genes silenced in cancer. Nature Genetics. 21: 103-7. PMID 9916800 DOI: 10.1038/5047  0.857
1999 Katzenellenbogen RA, Baylin SB, Herman JG. Hypermethylation of the DAP-Kinase CpG Island Is a Common Alteration in B-Cell Malignancies Blood. 93: 4347-4353. DOI: 10.1182/Blood.V93.12.4347.412K31_4347_4353  0.362
1999 Herman J, Esteller M, Corn P, Baylin S. Methylation inactivates critical pathways in tumourgenesis European Journal of Cancer. 35: S303. DOI: 10.1016/S0959-8049(99)81635-9  0.404
1998 Esteller M, Levine R, Baylin SB, Ellenson LH, Herman JG. MLH1 promoter hypermethylation is associated with the microsatellite instability phenotype in sporadic endometrial carcinomas. Oncogene. 17: 2413-7. PMID 9811473 DOI: 10.1038/Sj.Onc.1202178  0.436
1998 Belinsky SA, Nikula KJ, Palmisano WA, Michels R, Saccomanno G, Gabrielson E, Baylin SB, Herman JG. Aberrant methylation of p16(INK4a) is an early event in lung cancer and a potential biomarker for early diagnosis Proceedings of the National Academy of Sciences of the United States of America. 95: 11891-11896. PMID 9751761 DOI: 10.1073/Pnas.95.20.11891  0.483
1998 Narayan A, Ji W, Zhang XY, Marrogi A, Graff JR, Baylin SB, Ehrlich M. Hypomethylation of pericentromeric DNA in breast adenocarcinomas. International Journal of Cancer. Journal International Du Cancer. 77: 833-8. PMID 9714050 DOI: 10.1002/(Sici)1097-0215(19980911)77:6<833::Aid-Ijc6>3.0.Co;2-V  0.497
1998 Mikovits JA, Young HA, Vertino P, Issa JP, Pitha PM, Turcoski-Corrales S, Taub DD, Petrow CL, Baylin SB, Ruscetti FW. Infection with human immunodeficiency virus type 1 upregulates DNA methyltransferase, resulting in de novo methylation of the gamma interferon (IFN-gamma) promoter and subsequent downregulation of IFN-gamma production. Molecular and Cellular Biology. 18: 5166-77. PMID 9710601 DOI: 10.1128/Mcb.18.9.5166  0.452
1998 Carson-Walter EB, Smith DP, Ponder BA, Baylin SB, Nelkin BD. Post-transcriptional silencing of RET occurs, but is not required, during raf-1 mediated differentiation of medullary thyroid carcinoma cells. Oncogene. 17: 367-76. PMID 9690518 DOI: 10.1038/Sj.Onc.1201938  0.355
1998 Li Q, Jedlicka A, Ahuja N, Gibbons MC, Baylin SB, Burger PC, Issa JP. Concordant methylation of the ER and N33 genes in glioblastoma multiforme. Oncogene. 16: 3197-202. PMID 9671399 DOI: 10.1038/Sj.Onc.1201831  0.43
1998 Herman JG, Umar A, Polyak K, Graff JR, Ahuja N, Issa JPJ, Markowitz S, Willson JKV, Hamilton SR, Kinzler KW, Kane MF, Kolodner RD, Vogelstein B, Kunkel TA, Baylin SB. Incidence and functional consequences of hMLH1 promoter hypermethylation in colorectal carcinoma Proceedings of the National Academy of Sciences of the United States of America. 95: 6870-6875. PMID 9618505 DOI: 10.1073/Pnas.95.12.6870  0.569
1998 Fujii H, Biel MA, Zhou W, Weitzman SA, Baylin SB, Gabrielson E. Methylation of the HIC-1 candidate tumor suppressor gene in human breast cancer. Oncogene. 16: 2159-64. PMID 9572497 DOI: 10.1038/Sj.Onc.1201976  0.46
1998 Ravi RK, Weber E, McMahon M, Williams JR, Baylin S, Mal A, Harter ML, Dillehay LE, Claudio PP, Giordano A, Nelkin BD, Mabry M. Activated Raf-1 causes growth arrest in human small cell lung cancer cells. The Journal of Clinical Investigation. 101: 153-9. PMID 9421477 DOI: 10.1172/Jci831  0.38
1998 Ferguson AT, Vertino PM, Spitzner JR, Baylin SB, Muller MT, Davidson NE. Role of estrogen receptor gene demethylation and DNA methyltransferase.DNA adduct formation in 5-aza-2'deoxycytidine-induced cytotoxicity in human breast cancer cells. The Journal of Biological Chemistry. 272: 32260-6. PMID 9405430 DOI: 10.1074/Jbc.272.51.32260  0.5
1998 Baylin SB, Herman JG, Graff JR, Vertino PM, Issa JP. Alterations In Dna Methylation : A Fundamental Aspect Of Neoplasia Advances in Cancer Research. 72: 141-196. DOI: 10.1016/S0065-230X(08)60702-2  0.555
1997 Baylin SB. Tying it all together: epigenetics, genetics, cell cycle, and cancer. Science (New York, N.Y.). 277: 1948-9. PMID 9333948 DOI: 10.1126/Science.277.5334.1948  0.54
1997 Graff JR, Herman JG, Myöhänen S, Baylin SB, Vertino PM. Mapping patterns of CpG island methylation in normal and neoplastic cells implicates both upstream and downstream regions in de Novo methylation Journal of Biological Chemistry. 272: 22322-22329. PMID 9268383 DOI: 10.1074/Jbc.272.35.22322  0.494
1997 Jarrard DF, Bova GS, Ewing CM, Pin SS, Nguyen SH, Baylin SB, Cairns P, Sidransky D, Herman JG, Isaacs WB. Deletional, mutational, and methylation analyses of CDKN2 (p16/MTS1) in primary and metastatic prostate cancer. Genes, Chromosomes & Cancer. 19: 90-6. PMID 9171999 DOI: 10.1002/(Sici)1098-2264(199706)19:2<90::Aid-Gcc4>3.0.Co;2-V  0.499
1997 Chen H, Thiagalingam A, Chopra H, Borges MW, Feder JN, Nelkin BD, Baylin SB, Ball DW. Conservation of the Drosophila lateral inhibition pathway in human lung cancer: a hairy-related protein (HES-1) directly represses achaete-scute homolog-1 expression. Proceedings of the National Academy of Sciences of the United States of America. 94: 5355-60. PMID 9144241 DOI: 10.1073/Pnas.94.10.5355  0.433
1997 Borges M, Linnoila RI, van de Velde HJ, Chen H, Nelkin BD, Mabry M, Baylin SB, Ball DW. An achaete-scute homologue essential for neuroendocrine differentiation in the lung. Nature. 386: 852-5. PMID 9126746 DOI: 10.1038/386852A0  0.395
1997 Swafford DS, Middleton SK, Palmisano WA, Nikula KJ, Tesfaigzi J, Baylin SB, Herman JG, Belinsky SA. Frequent aberrant methylation of p16INK4a in primary rat lung tumors. Molecular and Cellular Biology. 17: 1366-74. PMID 9032263 DOI: 10.1128/Mcb.17.3.1366  0.485
1997 Yoder JA, Yen RW, Vertino PM, Bestor TH, Baylin SB. New 5' regions of the murine and human genes for DNA (cytosine-5)-methyltransferase. The Journal of Biological Chemistry. 271: 31092-7. PMID 8940105 DOI: 10.1074/Jbc.271.49.31092  0.515
1996 Issa JP, Vertino PM, Boehm CD, Newsham IF, Baylin SB. Switch from monoallelic to biallelic human IGF2 promoter methylation during aging and carcinogenesis. Proceedings of the National Academy of Sciences of the United States of America. 93: 11757-62. PMID 8876210 DOI: 10.1073/Pnas.93.21.11757  0.467
1996 Thiagalingam A, De Bustros A, Borges M, Jasti R, Compton D, Diamond L, Mabry M, Ball DW, Baylin SB, Nelkin BD. RREB-1, a novel zinc finger protein, is involved in the differentiation response to Ras in human medullary thyroid carcinomas. Molecular and Cellular Biology. 16: 5335-45. PMID 8816445 DOI: 10.1128/Mcb.16.10.5335  0.38
1996 Herman JG, Graff JR, Myöhänen S, Nelkin BD, Baylin SB. Methylation-specific PCR: A novel PCR assay for methylation status of CpG islands Proceedings of the National Academy of Sciences of the United States of America. 93: 9821-9826. PMID 8790415 DOI: 10.1073/Pnas.93.18.9821  0.558
1996 Vertino PM, Yen RW, Gao J, Baylin SB. De novo methylation of CpG island sequences in human fibroblasts overexpressing DNA (cytosine-5-)-methyltransferase. Molecular and Cellular Biology. 16: 4555-65. PMID 8754856 DOI: 10.1128/Mcb.16.8.4555  0.525
1996 Chen H, Carson-Walter EB, Baylin SB, Nelkin BD, Ball DW. Differentiation of medullary thyroid cancer by C-Raf-1 silences expression of the neural transcription factor human achaete-scute homolog-1. Surgery. 120: 168-72; discussion 1. PMID 8751579 DOI: 10.1016/S0039-6060(96)80284-4  0.403
1996 Belinsky SA, Nikula KJ, Baylin SB, Issa JPJ. Increased cytosine DNA-methyltransferase activity is target-cell-specific and an early event in lung cancer Proceedings of the National Academy of Sciences of the United States of America. 93: 4045-4050. PMID 8633014 DOI: 10.1073/Pnas.93.9.4045  0.504
1996 Issa JPJ, Baylin SB. Epigenetics and human disease Nature Medicine. 2: 281-282. PMID 8612223 DOI: 10.1038/Nm0396-281  0.324
1995 Belinsky SA, Nikula KJ, Baylin SB, Issa Jp. A microassay for measuring cytosine DNA methyltransferase activity during tumor progression Toxicology Letters. 82: 335-340. PMID 8597074 DOI: 10.1016/0378-4274(95)03486-2  0.448
1995 Merlo A, Herman JG, Mao L, Lee DJ, Gabrielson E, Burger PC, Baylin SB, Sidransky D. 5' CpG island methylation is associated with transcriptional silencing of the tumour suppressor p16/CDKN2/MTS1 in human cancers. Nature Medicine. 1: 686-92. PMID 7585152 DOI: 10.1038/Nm0795-686  0.485
1995 Wales MM, Biel MA, el Deiry W, Nelkin BD, Issa JP, Cavenee WK, Kuerbitz SJ, Baylin SB. p53 activates expression of HIC-1, a new candidate tumour suppressor gene on 17p13.3. Nature Medicine. 1: 570-7. PMID 7585125 DOI: 10.1038/Nm0695-570  0.459
1995 Nelson C, Issa J, Giardiello F, Hamilton S, Baylin S, Petersen G. Pattern of estrogen receptor gene methylation in colonic tissue is associated with age and site Gastroenterology. 108: A514. DOI: 10.1016/0016-5085(95)26371-3  0.372
1994 Issa JP, Ottaviano YL, Celano P, Hamilton SR, Davidson NE, Baylin SB. Methylation of the oestrogen receptor CpG island links ageing and neoplasia in human colon. Nature Genetics. 7: 536-40. PMID 7951326 DOI: 10.1038/Ng0894-536  0.518
1994 Blaugrund JE, Johns MM, Eby YJ, Ball DW, Baylin SB, Hruban RH, Sidransky D. RET proto-oncogene mutations in inherited and sporadic medullary thyroid cancer. Human Molecular Genetics. 3: 1895-7. PMID 7849720 DOI: 10.1093/Hmg/3.10.1895  0.314
1994 Nelkin BD, Ball DW, Baylin SB. Molecular Abnormalities in Tumors Associated with Multiple Endocrine Neoplasia Type 2 Endocrinology and Metabolism Clinics of North America. 23: 187-213. DOI: 10.1016/S0889-8529(18)30125-7  0.31
1993 Wu J, Issa JP, Herman J, Bassett DE, Nelkin BD, Baylin SB. Expression of an exogenous eukaryotic DNA methyltransferase gene induces transformation of NIH 3T3 cells. Proceedings of the National Academy of Sciences of the United States of America. 90: 8891-5. PMID 8415627 DOI: 10.1073/Pnas.90.19.8891  0.524
1993 Ball DW, Azzoli CG, Baylin SB, Chi D, Dou S, Donis-Keller H, Cumaraswamy A, Borges M, Nelkin BD. Identification of a human achaete-scute homolog highly expressed in neuroendocrine tumors. Proceedings of the National Academy of Sciences of the United States of America. 90: 5648-52. PMID 8390674 DOI: 10.1073/Pnas.90.12.5648  0.442
1993 Issa JP, Vertino PM, Wu J, Sazawal S, Celano P, Nelkin BD, Hamilton SR, Baylin SB. Increased cytosine DNA-methyltransferase activity during colon cancer progression. Journal of the National Cancer Institute. 85: 1235-40. PMID 8331684 DOI: 10.1093/Jnci/85.15.1235  0.512
1992 Ball DW, Compton D, Nelkin BD, Baylin SB, de Bustros A. Human calcitonin gene regulation by helix-loop-helix recognition sequences. Nucleic Acids Research. 20: 117-23. PMID 1738589 DOI: 10.1093/Nar/20.1.117  0.395
1992 Yen RW, Vertino PM, Nelkin BD, Yu JJ, el-Deiry W, Cumaraswamy A, Lennon GG, Trask BJ, Celano P, Baylin SB. Isolation and characterization of the cDNA encoding human DNA methyltransferase. Nucleic Acids Research. 20: 2287-91. PMID 1594447 DOI: 10.1093/Nar/20.9.2287  0.43
1992 Fukuhara T, Hooper WC, Baylin SB, Benson J, Pruckler J, Olson AC, Evatt BL, Vogler WR. Use of the polymerase chain reaction to detect hypermethylation in the calcitonin gene. A new, sensitive approach to monitor tumor cells in acute myelogenous leukemia. Leukemia Research. 16: 1031-40. PMID 1405705 DOI: 10.1016/0145-2126(92)90083-J  0.43
1992 Makos M, Nelkin BD, Lerman MI, Latif F, Zbar B, Baylin SB. Distinct hypermethylation patterns occur at altered chromosome loci in human lung and colon cancer. Proceedings of the National Academy of Sciences of the United States of America. 89: 1929-33. PMID 1347428 DOI: 10.1073/Pnas.89.5.1929  0.511
1991 El-Deiry WS, Nelkin BD, Celano P, Yen RWC, Falco JP, Hamilton SR, Baylin SB. High expression of the DNA methyltransferase gene characterizes human neoplastic cells and progression stages of colon cancer Proceedings of the National Academy of Sciences of the United States of America. 88: 3470-3474. PMID 2014266 DOI: 10.1073/Pnas.88.8.3470  0.575
1991 Nelkin B, Przepiorka D, Burke P, Thomas E, Baylin S. Abnormal methylation of the calcitonin gene marks progression of chronic myelogenous leukemia Blood. 77: 2431-2434. DOI: 10.1182/Blood.V77.11.2431.Bloodjournal77112431  0.436
1991 Nelkin B, Przepiorka D, Burke P, Thomas E, Baylin S. Abnormal methylation of the calcitonin gene marks progression of chronic myelogenous leukemia Blood. 77: 2431-2434. DOI: 10.1182/blood.v77.11.2431.bloodjournal77112431  0.324
1990 Falco JP, Baylin SB, Lupu R, Borges M, Nelkin BD, Jasti RK, Davidson NE, Mabry M. v-rasH induces non-small cell phenotype, with associated growth factors and receptors, in a small cell lung cancer cell line. The Journal of Clinical Investigation. 85: 1740-5. PMID 2161428 DOI: 10.1172/Jci114630  0.351
1990 de Bustros A, Lee RY, Compton D, Tsong TY, Baylin SB, Nelkin BD. Differential utilization of calcitonin gene regulatory DNA sequences in cultured lines of medullary thyroid carcinoma and small-cell lung carcinoma. Molecular and Cellular Biology. 10: 1773-8. PMID 2157143 DOI: 10.1128/Mcb.10.4.1773  0.4
1990 Nelkin BD, Borges M, Mabry M, Baylin SB. Transcription factor levels in medullary thyroid carcinoma cells differentiated by Harvey ras oncogene: c-jun is increased. Biochemical and Biophysical Research Communications. 170: 140-6. PMID 2115330 DOI: 10.1016/0006-291X(90)91251-M  0.331
1989 Hausheer FH, Rao SN, Gamcsik MP, Kollman PA, Colvin OM, Saxe JD, Nelkin BD, McLennan IJ, Barnett G, Baylin SB. Computational analysis of structural and energetic consequences of DNA methylation. Carcinogenesis. 10: 1131-7. PMID 2720906 DOI: 10.1093/Carcin/10.6.1131  0.502
1989 Baylin SB. Neuroendocrine differentiation: a prognostic feature of non-small-cell lung cancer? Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology. 7: 1375-6. PMID 2550589 DOI: 10.1200/Jco.1989.7.10.1375  0.34
1989 Mabry M, Nakagawa T, Baylin S, Pettengill O, Sorenson G, Nelkin B. Insertion of the v-Ha-ras oncogene induces differentiation of calcitonin-producing human small cell lung cancer. Journal of Clinical Investigation. 84: 194-199. PMID 2544624 DOI: 10.1172/Jci114140  0.392
1989 Nigro JM, Baker SJ, Preisinger AC, Jessup JM, Hostetter R, Cleary K, Bigner SH, Davidson N, Baylin S, Devilee P. Mutations in the p53 gene occur in diverse human tumour types. Nature. 342: 705-8. PMID 2531845 DOI: 10.1038/342705A0  0.36
1988 Tockman MS, Gupta PK, Myers JD, Frost JK, Baylin SB, Gold EB, Chase AM, Wilkinson PH, Mulshine JL. Sensitive and specific monoclonal antibody recognition of human lung cancer antigen on preserved sputum cells: a new approach to early lung cancer detection. Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology. 6: 1685-93. PMID 2846790 DOI: 10.1200/Jco.1988.6.11.1685  0.355
1988 Mabry M, Nakagawa T, Nelkin BD, McDowell E, Gesell M, Eggleston JC, Casero RA, Baylin SB. v-Ha-ras oncogene insertion: a model for tumor progression of human small cell lung cancer. Proceedings of the National Academy of Sciences of the United States of America. 85: 6523-7. PMID 2842776 DOI: 10.1073/Pnas.85.17.6523  0.402
1988 de Bustros A, Nelkin BD, Silverman A, Ehrlich G, Poiesz B, Baylin SB. The short arm of chromosome 11 is a "hot spot" for hypermethylation in human neoplasia. Proceedings of the National Academy of Sciences of the United States of America. 85: 5693-7. PMID 2840671 DOI: 10.1073/Pnas.85.15.5693  0.569
1987 Nakagawa T, Mabry M, de Bustros A, Ihle JN, Nelkin BD, Baylin SB. Introduction of v-Ha-ras oncogene induces differentiation of cultured human medullary thyroid carcinoma cells. Proceedings of the National Academy of Sciences of the United States of America. 84: 5923-7. PMID 3112776 DOI: 10.1073/Pnas.84.16.5923  0.41
1987 Baylin S, Fearon E, Vogelstein B, de Bustros A, Sharkis S, Burke P, Staal S, Nelkin B. Hypermethylation of the 5' region of the calcitonin gene is a property of human lymphoid and acute myeloid malignancies Blood. 70: 412-417. DOI: 10.1182/Blood.V70.2.412.Bloodjournal702412  0.464
1987 Baylin S, Fearon E, Vogelstein B, de Bustros A, Sharkis S, Burke P, Staal S, Nelkin B. Hypermethylation of the 5' region of the calcitonin gene is a property of human lymphoid and acute myeloid malignancies Blood. 70: 412-417. DOI: 10.1182/blood.v70.2.412.412  0.359
1986 Wong AJ, Ruppert JM, Eggleston J, Hamilton SR, Baylin SB, Vogelstein B. Gene amplification of c-myc and N-myc in small cell carcinoma of the lung. Science (New York, N.Y.). 233: 461-4. PMID 3014659 DOI: 10.1126/Science.3014659  0.356
1986 Casero RA, Baylin SB, Nelkin BD, Luk GD. Human lung tumor sensitivity to difluoromethylornithine as related to ornithine decarboxylase messenger RNA levels. Biochemical and Biophysical Research Communications. 134: 572-9. PMID 3004454 DOI: 10.1016/S0006-291X(86)80458-2  0.345
1986 Ruppert JM, Eggleston JC, deBustros A, Baylin SB. Disseminated calcitonin-poor medullary thyroid carcinoma in a patient with calcitonin-rich primary tumor. The American Journal of Surgical Pathology. 10: 513-8. PMID 2873751 DOI: 10.1097/00000478-198607000-00009  0.301
1985 Griffin CA, Baylin SB. Oncogene expression in human small cell lung carcinoma Recent Results in Cancer Research. Fortschritte Der Krebsforschung. Progres Dans Les Recherches Sur Le Cancer. 99: 237-245. PMID 2999920 DOI: 10.1007/978-3-642-82533-0_25  0.34
1985 Gazdar AF, Bunn PA, Minna JD, Baylin SB. Origin of human small cell lung cancer. Science (New York, N.Y.). 229: 679-80. PMID 2992083 DOI: 10.1126/Science.2992083  0.354
1985 de Bustros A, Baylin SB. Hormone production by tumours: biological and clinical aspects. Clinics in Endocrinology and Metabolism. 14: 221-56. PMID 2990776 DOI: 10.1016/S0300-595X(85)80071-2  0.302
1985 Bernal SD, Stahel RA, Baylin SB. Cytoskeleton-associated proteins: their role as cellular integrators in the neoplastic process. Critical Reviews in Oncology Hematology. 3: 191-204. PMID 2412718 DOI: 10.1016/S1040-8428(85)80026-3  0.316
1984 Przepiorka D, Baylin SB, McBride OW, Testa JR, de Bustros A, Nelkin BD. The human calcitonin gene is located on the short arm of chromosome 11. Biochemical and Biophysical Research Communications. 120: 493-9. PMID 6547335 DOI: 10.1016/0006-291X(84)91281-6  0.361
1984 Luk GD, Baylin SB. Inhibition of intestinal epithelial DNA synthesis and adaptive hyperplasia after jejunectomy in the rat by suppression of polyamine biosynthesis. The Journal of Clinical Investigation. 74: 698-704. PMID 6432848 DOI: 10.1172/Jci111485  0.35
1984 Nelkin BD, Rosenfeld KI, de Bustros A, Leong SS, Roos BA, Baylin SB. Structure and expression of a gene encoding human calcitonin and calcitonin gene related peptide. Biochemical and Biophysical Research Communications. 123: 648-55. PMID 6148938 DOI: 10.1016/0006-291X(84)90278-X  0.377
1983 Feinberg AP, Vogelstein B, Droller MJ, Baylin SB, Nelkin BD. Mutation affecting the 12th amino acid of the c-Ha-ras oncogene product occurs infrequently in human cancer. Science (New York, N.Y.). 220: 1175-7. PMID 6304875 DOI: 10.1126/Science.6304875  0.356
1983 Goodwin G, Shaper JH, Abeloff MD, Mendelsohn G, Baylin SB. Analysis of cell surface proteins delineates a differentiation pathway linking endocrine and nonendocrine human lung cancers. Proceedings of the National Academy of Sciences of the United States of America. 80: 3807-11. PMID 6304739 DOI: 10.1073/Pnas.80.12.3807  0.358
1983 Sharkis S, Luk G, Collector M, McCann P, Baylin S, Sensenbrenner L. Regulation of hematopoiesis II: the role of polyamine inhibition on helper or suppressor influences of the thymus Blood. 61: 604-607. DOI: 10.1182/Blood.V61.3.604.604  0.333
1982 Luk GD, Civin CI, Weissman RM, Baylin SB. Ornithine decarboxylase: essential in proliferation but not differentiation of human promyelocytic leukemia cells. Science (New York, N.Y.). 216: 75-7. PMID 6950518 DOI: 10.1126/Science.6950518  0.332
1982 Baylin SB, Gazdar AF, Minna JD, Bernal SD, Shaper JH. A unique cell-surface protein phenotype distinguishes human small-cell from non-small-cell lung cancer. Proceedings of the National Academy of Sciences of the United States of America. 79: 4650-4. PMID 6289311 DOI: 10.1073/Pnas.79.15.4650  0.352
1981 Abeloff MD, Trump DL, Baylin SB. Ectopic adrenocorticotrophic (ACTH) syndrome and small cell carcinoma of the lung-assessment of clinical implications in patients on combination chemotherapy. Cancer. 48: 1082-7. PMID 6268276 DOI: 10.1002/1097-0142(19810901)48:5<1082::Aid-Cncr2820480505>3.0.Co;2-J  0.309
1981 Luk GD, Goodwin G, Marton LJ, Baylin SB. Polyamines are necessary for the survival of human small-cell lung carcinoma in culture. Proceedings of the National Academy of Sciences of the United States of America. 78: 2355-8. PMID 6264474 DOI: 10.1073/Pnas.78.4.2355  0.311
1981 Baylin SB, Mendelsohn G. Ectopic (inappropriate) hormone production by tumors: mechanisms involved and the biological and clinical implications. Endocrine Reviews. 1: 45-77. PMID 6164550 DOI: 10.1210/Edrv-1-1-45  0.302
1981 Berger CL, Goodwin G, Mendelsohn G, Eggleston JC, Abeloff MD, Aisner S, Baylin SB. Endocrine-related biochemistry in the spectrum of human lung carcinoma. The Journal of Clinical Endocrinology and Metabolism. 53: 422-9. PMID 6114110 DOI: 10.1210/Jcem-53-2-422  0.339
1980 Roos BA, Lindall AW, Baylin SB, O'Neil J, Frelinger AL, Birnbaum RS, Lambert PW. Plasma immunoreactive calcitonin in lung cancer. Endocrine Research Communications. 6: 169-90. PMID 228926 DOI: 10.1080/07435807909061104  0.304
1979 Abeloff MD, Eggleston JC, Mendelsohn G, Ettinger DS, Baylin SB. Changes in morphologic and biochemical characteristics of small cell carcinoma of the lung. A clinicopathologic study The American Journal of Medicine. 66: 757-764. PMID 220872 DOI: 10.1016/0002-9343(79)91113-6  0.33
1978 Baylin SB, Weisburger WR, Eggleston JC, Mendelsohn G, Beaven MA, Abeloff MD, Ettinger DS. Variable content of histaminase, L-dopa decarboxylase and calcitonin in small-cell carcinoma of the lung. Biologic and clinical implications. The New England Journal of Medicine. 299: 105-10. PMID 26872 DOI: 10.1056/Nejm197807202990301  0.304
1977 Baylin SB. Histaminase (diamine oxidase) activity in human tumors: an expression of a mature genome. Proceedings of the National Academy of Sciences of the United States of America. 74: 883-7. PMID 191838 DOI: 10.1073/Pnas.74.3.883  0.308
1975 Baylin SB, Abeloff MD, Wieman KC, Tomford JW, Ettinger DS. Elevated histaminase (diamine oxidase) activity in small cell carcinoma of the lung New England Journal of Medicine. 293: 1286-1290. PMID 171575 DOI: 10.1056/Nejm197512182932504  0.303
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