Leona D. Samson - Publications

Harvard University, Cambridge, MA, United States 
Genetics, Molecular Biology, Cell Biology

64 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2017 Chaim IA, Nagel ZD, Jordan JJ, Mazzucato P, Ngo LP, Samson LD. In vivo measurements of interindividual differences in DNA glycosylases and APE1 activities. Proceedings of the National Academy of Sciences of the United States of America. PMID 29122935 DOI: 10.1073/pnas.1712032114  0.56
2017 Allocca M, Corrigan JJ, Fake KR, Calvo JA, Samson LD. PARP inhibitors protect against sex- and AAG-dependent alkylation-induced neural degeneration. Oncotarget. 8: 68707-68720. PMID 28978150 DOI: 10.18632/oncotarget.19844  0.36
2017 Jordan JJ, Chhim S, Margulies CM, Allocca M, Bronson RT, Klungland A, Samson LD, Fu D. ALKBH7 drives a tissue and sex-specific necrotic cell death response following alkylation-induced damage. Cell Death & Disease. 8: e2947. PMID 28726787 DOI: 10.1038/cddis.2017.343  1
2016 Calvo JA, Allocca M, Fake KR, Muthupalani S, Corrigan JJ, Bronson RT, Samson LD. Parp1 protects against Aag-dependent alkylation-induced nephrotoxicity in a sex-dependent manner. Oncotarget. PMID 27391435 DOI: 10.18632/oncotarget.10440  1
2016 Yu AM, Calvo JA, Muthupalani S, Samson LD. The Mbd4 DNA glycosylase protects mice from inflammation-driven colon cancer and tissue injury. Oncotarget. PMID 27086921 DOI: 10.18632/oncotarget.8721  1
2015 Fu D, Samson LD, Hübscher U, van Loon B. The interaction between ALKBH2 DNA repair enzyme and PCNA is direct, mediated by the hydrophobic pocket of PCNA and perturbed in naturally-occurring ALKBH2 variants. Dna Repair. 35: 13-18. PMID 26408825 DOI: 10.1016/j.dnarep.2015.09.008  0.4
2015 McFaline-Figueroa JL, Braun CJ, Stanciu M, Nagel ZD, Mazzucato P, Sangaraju D, Cerniauskas E, Barford K, Vargas A, Chen Y, Tretyakova N, Lees JA, Hemann MT, White FM, Samson LD. Minor Changes in Expression of the Mismatch Repair Protein MSH2 Exert a Major Impact on Glioblastoma Response to Temozolomide. Cancer Research. PMID 26025730 DOI: 10.1158/0008-5472.CAN-14-3616  1
2014 Ebrahimkhani MR, Daneshmand A, Mazumder A, Allocca M, Calvo JA, Abolhassani N, Jhun I, Muthupalani S, Ayata C, Samson LD. Aag-initiated base excision repair promotes ischemia reperfusion injury in liver, brain, and kidney. Proceedings of the National Academy of Sciences of the United States of America. 111: E4878-86. PMID 25349415 DOI: 10.1073/pnas.1413582111  1
2014 Kiraly O, Gong G, Roytman MD, Yamada Y, Samson LD, Engelward BP. DNA glycosylase activity and cell proliferation are key factors in modulating homologous recombination in vivo. Carcinogenesis. 35: 2495-502. PMID 25155011 DOI: 10.1093/carcin/bgu177  0.4
2014 Meira LB, Calvo JA, Shah D, Klapacz J, Moroski-Erkul CA, Bronson RT, Samson LD. Repair of endogenous DNA base lesions modulate lifespan in mice. Dna Repair. 21: 78-86. PMID 24994062 DOI: 10.1016/j.dnarep.2014.05.012  1
2014 Nagel ZD, Margulies CM, Chaim IA, McRee SK, Mazzucato P, Ahmad A, Abo RP, Butty VL, Forget AL, Samson LD. Multiplexed DNA repair assays for multiple lesions and multiple doses via transcription inhibition and transcriptional mutagenesis. Proceedings of the National Academy of Sciences of the United States of America. 111: E1823-32. PMID 24757057 DOI: 10.1073/pnas.1401182111  1
2013 Svensson JP, Quirós Pesudo L, McRee SK, Adeleye Y, Carmichael P, Samson LD. Genomic phenotyping by barcode sequencing broadly distinguishes between alkylating agents, oxidizing agents, and non-genotoxic agents, and reveals a role for aromatic amino acids in cellular recovery after quinone exposure. Plos One. 8: e73736. PMID 24040048 DOI: 10.1371/journal.pone.0073736  1
2013 Mazumder A, Pesudo LQ, McRee S, Bathe M, Samson LD. Genome-wide single-cell-level screen for protein abundance and localization changes in response to DNA damage in S. cerevisiae. Nucleic Acids Research. 41: 9310-24. PMID 23935119 DOI: 10.1093/nar/gkt715  1
2013 Fu D, Jordan JJ, Samson LD. Human ALKBH7 is required for alkylation and oxidation-induced programmed necrosis. Genes & Development. 27: 1089-100. PMID 23666923 DOI: 10.1101/gad.215533.113  1
2013 Calvo JA, Moroski-Erkul CA, Lake A, Eichinger LW, Shah D, Jhun I, Limsirichai P, Bronson RT, Christiani DC, Meira LB, Samson LD. Aag DNA glycosylase promotes alkylation-induced tissue damage mediated by Parp1. Plos Genetics. 9: e1003413. PMID 23593019 DOI: 10.1371/journal.pgen.1003413  0.36
2013 van Loon B, Samson LD. Alkyladenine DNA glycosylase (AAG) localizes to mitochondria and interacts with mitochondrial single-stranded binding protein (mtSSB). Dna Repair. 12: 177-87. PMID 23290262 DOI: 10.1016/j.dnarep.2012.11.009  0.4
2013 Mazumder A, Tummler K, Bathe M, Samson LD. Single-cell analysis of ribonucleotide reductase transcriptional and translational response to DNA damage. Molecular and Cellular Biology. 33: 635-42. PMID 23184665 DOI: 10.1128/MCB.01020-12  1
2012 Noonan EM, Shah D, Yaffe MB, Lauffenburger DA, Samson LD. O6-Methylguanine DNA lesions induce an intra-S-phase arrest from which cells exit into apoptosis governed by early and late multi-pathway signaling network activation. Integrative Biology : Quantitative Biosciences From Nano to Macro. 4: 1237-55. PMID 22892544 DOI: 10.1039/c2ib20091k  1
2012 Calvo JA, Meira LB, Lee CY, Moroski-Erkul CA, Abolhassani N, Taghizadeh K, Eichinger LW, Muthupalani S, Nordstrand LM, Klungland A, Samson LD. DNA repair is indispensable for survival after acute inflammation. The Journal of Clinical Investigation. 122: 2680-9. PMID 22684101 DOI: 10.1172/JCI63338  1
2012 Svensson JP, Fry RC, Wang E, Somoza LA, Samson LD. Identification of novel human damage response proteins targeted through yeast orthology. Plos One. 7: e37368. PMID 22615993 DOI: 10.1371/journal.pone.0037368  1
2012 Olipitz W, Wiktor-Brown D, Shuga J, Pang B, McFaline J, Lonkar P, Thomas A, Mutamba JT, Greenberger JS, Samson LD, Dedon PC, Yanch JC, Engelward BP. Integrated molecular analysis indicates undetectable change in DNA damage in mice after continuous irradiation at ~ 400-fold natural background radiation. Environmental Health Perspectives. 120: 1130-6. PMID 22538203 DOI: 10.1289/ehp.1104294  1
2012 Tentner AR, Lee MJ, Ostheimer GJ, Samson LD, Lauffenburger DA, Yaffe MB. Combined experimental and computational analysis of DNA damage signaling reveals context-dependent roles for Erk in apoptosis and G1/S arrest after genotoxic stress. Molecular Systems Biology. 8: 568. PMID 22294094 DOI: 10.1038/msb.2012.1  1
2012 Fu D, Calvo JA, Samson LD. Balancing repair and tolerance of DNA damage caused by alkylating agents. Nature Reviews. Cancer. 12: 104-20. PMID 22237395 DOI: 10.1038/nrc3185  1
2012 Setser JW, Lingaraju GM, Davis CA, Samson LD, Drennan CL. Searching for DNA lesions: structural evidence for lower- and higher-affinity DNA binding conformations of human alkyladenine DNA glycosylase. Biochemistry. 51: 382-90. PMID 22148158 DOI: 10.1021/bi201484k  1
2012 Fu D, Samson LD. Direct repair of 3,N(4)-ethenocytosine by the human ALKBH2 dioxygenase is blocked by the AAG/MPG glycosylase. Dna Repair. 11: 46-52. PMID 22079122 DOI: 10.1016/j.dnarep.2011.10.004  1
2011 Svensson JP, Pesudo LQ, Fry RC, Adeleye YA, Carmichael P, Samson LD. Genomic phenotyping of the essential and non-essential yeast genome detects novel pathways for alkylation resistance. Bmc Systems Biology. 5: 157. PMID 21978764 DOI: 10.1186/1752-0509-5-157  1
2011 Kisby GE, Fry RC, Lasarev MR, Bammler TK, Beyer RP, Churchwell M, Doerge DR, Meira LB, Palmer VS, Ramos-Crawford AL, Ren X, Sullivan RC, Kavanagh TJ, Samson LD, Zarbl H, et al. The cycad genotoxin MAM modulates brain cellular pathways involved in neurodegenerative disease and cancer in a DNA damage-linked manner. Plos One. 6: e20911. PMID 21731631 DOI: 10.1371/journal.pone.0020911  1
2011 Lingaraju GM, Davis CA, Setser JW, Samson LD, Drennan CL. Structural basis for the inhibition of human alkyladenine DNA glycosylase (AAG) by 3,N4-ethenocytosine-containing DNA. The Journal of Biological Chemistry. 286: 13205-13. PMID 21349833 DOI: 10.1074/jbc.M110.192435  1
2010 Klapacz J, Lingaraju GM, Guo HH, Shah D, Moar-Shoshani A, Loeb LA, Samson LD. Frameshift Mutagenesis and Microsatellite Instability Induced by Human Alkyladenine DNA Glycosylase Molecular Cell. 37: 843-853. PMID 20347426 DOI: 10.1016/j.molcel.2010.01.038  1
2010 Fu D, Brophy JA, Chan CT, Atmore KA, Begley U, Paules RS, Dedon PC, Begley TJ, Samson LD. Human AlkB homolog ABH8 Is a tRNA methyltransferase required for wobble uridine modification and DNA damage survival. Molecular and Cellular Biology. 30: 2449-59. PMID 20308323 DOI: 10.1128/MCB.01604-09  1
2009 Lee CY, Delaney JC, Kartalou M, Lingaraju GM, Maor-Shoshani A, Essigmann JM, Samson LD. Recognition and processing of a new repertoire of DNA substrates by human 3-methyladenine DNA glycosylase (AAG). Biochemistry. 48: 1850-61. PMID 19219989 DOI: 10.1021/bi8018898  1
2009 Meira LB, Moroski-Erkul CA, Green SL, Calvo JA, Bronson RT, Shah D, Samson LD. Aag-initiated base excision repair drives alkylation-induced retinal degeneration in mice. Proceedings of the National Academy of Sciences of the United States of America. 106: 888-93. PMID 19139400 DOI: 10.1073/pnas.0807030106  1
2009 Klapacz J, Meira LB, Luchetti DG, Calvo JA, Bronson RT, Edelmann W, Samson LD. O6-methylguanine-induced cell death involves exonuclease 1 as well as DNA mismatch recognition in vivo. Proceedings of the National Academy of Sciences of the United States of America. 106: 576-81. PMID 19124772 DOI: 10.1073/pnas.0811991106  1
2008 Erlich RL, Fry RC, Begley TJ, Daee DL, Lahue RS, Samson LD. Anc1, a protein associated with multiple transcription complexes, is involved in postreplication repair pathway in S. cerevisiae. Plos One. 3: e3717. PMID 19005567 DOI: 10.1371/journal.pone.0003717  1
2008 Fry RC, Svensson JP, Valiathan C, Wang E, Hogan BJ, Bhattacharya S, Bugni JM, Whittaker CA, Samson LD. Genomic predictors of interindividual differences in response to DNA damaging agents. Genes & Development. 22: 2621-6. PMID 18805990 DOI: 10.1101/gad.1688508  1
2008 Chen CY, Guo HH, Shah D, Blank A, Samson LD, Loeb LA. Substrate binding pocket residues of human alkyladenine-DNA glycosylase critical for methylating agent survival Dna Repair. 7: 1731-1745. PMID 18706524 DOI: 10.1016/j.dnarep.2008.06.019  1
2008 Meira LB, Bugni JM, Green SL, Lee CW, Pang B, Borenshtein D, Rickman BH, Rogers AB, Moroski-Erkul CA, McFaline JL, Schauer DB, Dedon PC, Fox JG, Samson LD. DNA damage induced by chronic inflammation contributes to colon carcinogenesis in mice. The Journal of Clinical Investigation. 118: 2516-25. PMID 18521188 DOI: 10.1172/JCI35073  1
2008 Ringvoll J, Moen MN, Nordstrand LM, Meira LB, Pang B, Bekkelund A, Dedon PC, Bjelland S, Samson LD, Falnes PØ, Klungland A. AlkB homologue 2-mediated repair of ethenoadenine lesions in mammalian DNA. Cancer Research. 68: 4142-9. PMID 18519673 DOI: 10.1158/0008-5472.CAN-08-0796  1
2008 Nagasubramanian R, Hansen RJ, Delaney SM, Cherian MM, Samson LD, Kogan SC, Dolan ME. Survival and tumorigenesis in O6-methylguanine DNA methyltransferase-deficient mice following cyclophosphamide exposure. Mutagenesis. 23: 341-6. PMID 18477655 DOI: 10.1093/mutage/gen018  1
2008 García A, Ihrig MM, Fry RC, Feng Y, Xu S, Boutin SR, Rogers AB, Muthupalani S, Samson LD, Fox JG. Genetic susceptibility to chronic hepatitis is inherited codominantly in Helicobacter hepaticus-infected AB6F1 and B6AF1 hybrid male mice, and progression to hepatocellular carcinoma is linked to hepatic expression of lipogenic genes and immune function-associated networks. Infection and Immunity. 76: 1866-76. PMID 18285497 DOI: 10.1128/IAI.01044-07  1
2007 Rusyn I, Fry RC, Begley TJ, Klapacz J, Svensson JP, Ambrose M, Samson LD. Transcriptional networks in S. cerevisiae linked to an accumulation of base excision repair intermediates. Plos One. 2: e1252. PMID 18043759 DOI: 10.1371/journal.pone.0001252  1
2007 Fry RC, Navasumrit P, Valiathan C, Svensson JP, Hogan BJ, Luo M, Bhattacharya S, Kandjanapa K, Soontararuks S, Nookabkaew S, Mahidol C, Ruchirawat M, Samson LD. Activation of inflammation/NF-kappaB signaling in infants born to arsenic-exposed mothers. Plos Genetics. 3: e207. PMID 18039032 DOI: 10.1371/journal.pgen.0030207  1
2007 Linding R, Jensen LJ, Ostheimer GJ, van Vugt MA, Jørgensen C, Miron IM, Diella F, Colwill K, Taylor L, Elder K, Metalnikov P, Nguyen V, Pasculescu A, Jin J, Park JG, ... Samson LD, et al. Systematic discovery of in vivo phosphorylation networks. Cell. 129: 1415-26. PMID 17570479 DOI: 10.1016/j.cell.2007.05.052  1
2007 Beyer RP, Fry RC, Lasarev MR, McConnachie LA, Meira LB, Palmer VS, Powell CL, Ross PK, Bammler TK, Bradford BU, Cranson AB, Cunningham ML, Fannin RD, Higgins GM, Hurban P, ... ... Samson LD, et al. Multicenter study of acetaminophen hepatotoxicity reveals the importance of biological endpoints in genomic analyses. Toxicological Sciences : An Official Journal of the Society of Toxicology. 99: 326-37. PMID 17562736 DOI: 10.1093/toxsci/kfm150  1
2007 Hwa AJ, Fry RC, Sivaraman A, So PT, Samson LD, Stolz DB, Griffith LG. Rat liver sinusoidal endothelial cells survive without exogenous VEGF in 3D perfused co-cultures with hepatocytes. Faseb Journal : Official Publication of the Federation of American Societies For Experimental Biology. 21: 2564-79. PMID 17426068 DOI: 10.1096/fj.06-7473com  1
2007 Hansen RJ, Nagasubramanian R, Delaney SM, Samson LD, Dolan ME. Role of O6-methylguanine-DNA methyltransferase in protecting from alkylating agent-induced toxicity and mutations in mice. Carcinogenesis. 28: 1111-6. PMID 17116724 DOI: 10.1093/carcin/bgl218  1
2006 Fry RC, DeMott MS, Cosgrove JP, Begley TJ, Samson LD, Dedon PC. The DNA-damage signature in Saccharomyces cerevisiae is associated with single-strand breaks in DNA. Bmc Genomics. 7: 313. PMID 17163986 DOI: 10.1186/1471-2164-7-313  1
2006 Han J, Tranah GJ, Hankinson SE, Samson LD, Hunter DJ. Polymorphisms in O6-methylguanine DNA methyltransferase and breast cancer risk. Pharmacogenetics and Genomics. 16: 469-74. PMID 16788379 DOI: 10.1097/01.fpc.0000215065.21718.4c  1
2006 Workman CT, Mak HC, McCuine S, Tagne JB, Agarwal M, Ozier O, Begley TJ, Samson LD, Ideker T. A systems approach to mapping DNA damage response pathways. Science (New York, N.Y.). 312: 1054-9. PMID 16709784 DOI: 10.1126/science.1122088  1
2006 Benn JA, Hu J, Hogan BJ, Fry RC, Samson LD, Thorsen T. Comparative modeling and analysis of microfluidic and conventional DNA microarrays. Analytical Biochemistry. 348: 284-93. PMID 16307717 DOI: 10.1016/j.ab.2005.10.033  1
2005 Delaney JC, Smeester L, Wong C, Frick LE, Taghizadeh K, Wishnok JS, Drennan CL, Samson LD, Essigmann JM. AlkB reverses etheno DNA lesions caused by lipid oxidation in vitro and in vivo. Nature Structural & Molecular Biology. 12: 855-60. PMID 16200073 DOI: 10.1038/nsmb996  1
2005 Fry RC, Begley TJ, Samson LD. Genome-wide responses to DNA-damaging agents. Annual Review of Microbiology. 59: 357-77. PMID 16153173 DOI: 10.1146/annurev.micro.59.031805.133658  1
2005 Bammler T, Beyer RP, Bhattacharya S, Boorman GA, Boyles A, Bradford BU, Bumgarner RE, Bushel PR, Chaturvedi K, Choi D, Cunningham ML, Deng S, Dressman HK, Fannin RD, Farin FM, ... ... Samson LD, et al. Standardizing global gene expression analysis between laboratories and across platforms. Nature Methods. 2: 351-6. PMID 15846362 DOI: 10.1038/nmeth754  1
2004 Said MR, Begley TJ, Oppenheim AV, Lauffenburger DA, Samson LD. Global network analysis of phenotypic effects: protein networks and toxicity modulation in Saccharomyces cerevisiae. Proceedings of the National Academy of Sciences of the United States of America. 101: 18006-11. PMID 15608068 DOI: 10.1073/pnas.0405996101  1
2004 Begley TJ, Rosenbach AS, Ideker T, Samson LD. Hot spots for modulating toxicity identified by genomic phenotyping and localization mapping. Molecular Cell. 16: 117-25. PMID 15469827 DOI: 10.1016/j.molcel.2004.09.005  1
2004 Begley TJ, Samson LD. Reversing DNA damage with a directional bias. Nature Structural & Molecular Biology. 11: 688-90. PMID 15280878 DOI: 10.1038/nsmb0804-688  0.36
2004 Begley TJ, Samson LD. Network responses to DNA damaging agents. Dna Repair. 3: 1123-32. PMID 15279801 DOI: 10.1016/j.dnarep.2004.03.013  0.36
2004 Sandercock LE, Kwok MC, Luchman HA, Mark SC, Giesbrecht JL, Samson LD, Jirik FR. Mutational-reporter transgenes rescued from mice lacking either Mgmt, or both Mgmt and Msh6 suggest that O6-alkylguanine-induced miscoding does not contribute to the spontaneous mutational spectrum. Oncogene. 23: 5931-40. PMID 15208683 DOI: 10.1038/sj.onc.1207791  1
2004 Hickman MJ, Samson LD. Apoptotic signaling in response to a single type of DNA lesion, O(6)-methylguanine. Molecular Cell. 14: 105-16. PMID 15068807 DOI: 10.1016/S1097-2765(04)00162-5  1
2003 Hofseth LJ, Khan MA, Ambrose M, Nikolayeva O, Xu-Welliver M, Kartalou M, Hussain SP, Roth RB, Zhou X, Mechanic LE, Zurer I, Rotter V, Samson LD, Harris CC. The adaptive imbalance in base excision-repair enzymes generates microsatellite instability in chronic inflammation. The Journal of Clinical Investigation. 112: 1887-94. PMID 14679184 DOI: 10.1172/JCI19757  1
2003 Begley TJ, Samson LD. Molecular biology: A fix for RNA. Nature. 421: 795-6. PMID 12594492 DOI: 10.1038/421795a  0.36
2003 Begley TJ, Samson LD. AlkB mystery solved: oxidative demethylation of N1-methyladenine and N3-methylcytosine adducts by a direct reversal mechanism. Trends in Biochemical Sciences. 28: 2-5. PMID 12517444  0.36
2002 Begley TJ, Rosenbach AS, Ideker T, Samson LD. Damage recovery pathways in Saccharomyces cerevisiae revealed by genomic phenotyping and interactome mapping Molecular Cancer Research. 1: 103-112. PMID 12496357  1
2002 Sobol RW, Watson DE, Nakamura J, Yakes FM, Hou E, Horton JK, Ladapo J, Van Houten B, Swenberg JA, Tindall KR, Samson LD, Wilson SH. Mutations associated with base excision repair deficiency and methylation-induced genotoxic stress. Proceedings of the National Academy of Sciences of the United States of America. 99: 6860-5. PMID 11983862 DOI: 10.1073/pnas.092662499  1
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