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H Peter Spielmann - Publications

Affiliations: 
University of Kentucky, Lexington, KY 
Area:
Biochemistry
Website:
https://biochemistry.med.uky.edu/users/hps
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42 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2015 Rising KA, Crenshaw CM, Koo HJ, Subramanian T, Chehade KA, Starks C, Allen KD, Andres DA, Spielmann HP, Noel JP, Chappell J. Formation of a Novel Macrocyclic Alkaloid from the Unnatural Farnesyl Diphosphate Analogue Anilinogeranyl Diphosphate by 5-Epi-Aristolochene Synthase. Acs Chemical Biology. 10: 1729-36. PMID 25897591 DOI: 10.1021/Acschembio.5B00145  0.764
2013 Onono F, Subramanian T, Sunkara M, Subramanian KL, Spielmann HP, Morris AJ. Efficient use of exogenous isoprenols for protein isoprenylation by MDA-MB-231 cells is regulated independently of the mevalonate pathway. The Journal of Biological Chemistry. 288: 27444-55. PMID 23908355 DOI: 10.1074/Jbc.M113.482307  0.331
2012 Subramanian T, Parkin S, Spielmann HP. Synthesis of Farnesol Analogues Containing Triazoles in Place of Isoprenes through 'Click Chemistry' Synlett : Accounts and Rapid Communications in Synthetic Organic Chemistry. 23: 2539-2543. PMID 23125482 DOI: 10.1055/S-0031-1290461  0.314
2012 Subramanian T, Pais JE, Liu S, Troutman JM, Suzuki Y, Leela Subramanian K, Fierke CA, Andres DA, Spielmann HP. Farnesyl diphosphate analogues with aryl moieties are efficient alternate substrates for protein farnesyltransferase. Biochemistry. 51: 8307-19. PMID 22989235 DOI: 10.1021/Bi3011362  0.739
2012 Chang SY, Hudon-Miller SE, Yang SH, Jung HJ, Lee JM, Farber E, Subramanian T, Andres DA, Spielmann HP, Hrycyna CA, Young SG, Fong LG. Inhibitors of protein geranylgeranyltransferase-I lead to prelamin A accumulation in cells by inhibiting ZMPSTE24. Journal of Lipid Research. 53: 1176-82. PMID 22448028 DOI: 10.1194/Jlr.M026161  0.31
2010 Adams VR, Deremer DL, Stevich B, Mattingly CA, Gallt B, Subramanian T, Troutman JM, Spielmann HP. Anticancer activity of novel unnatural synthetic isoprenoids. Anticancer Research. 30: 2505-12. PMID 20682975  0.662
2010 Davies BS, Barnes RH, Tu Y, Ren S, Andres DA, Spielmann HP, Lammerding J, Wang Y, Young SG, Fong LG. An accumulation of non-farnesylated prelamin A causes cardiomyopathy but not progeria. Human Molecular Genetics. 19: 2682-94. PMID 20421363 DOI: 10.1093/Hmg/Ddq158  0.308
2010 Miriyala S, Subramanian T, Panchatcharam M, Ren H, McDermott MI, Sunkara M, Drennan T, Smyth SS, Spielmann HP, Morris AJ. Functional characterization of the atypical integral membrane lipid phosphatase PDP1/PPAPDC2 identifies a pathway for interconversion of isoprenols and isoprenoid phosphates in mammalian cells. The Journal of Biological Chemistry. 285: 13918-29. PMID 20110354 DOI: 10.1074/Jbc.M109.083931  0.309
2010 Onono FO, Morgan MA, Spielmann HP, Andres DA, Subramanian T, Ganser A, Reuter CW. A tagging-via-substrate approach to detect the farnesylated proteome using two-dimensional electrophoresis coupled with Western blotting. Molecular & Cellular Proteomics : McP. 9: 742-51. PMID 20103566 DOI: 10.1074/Mcp.M900597-Mcp200  0.374
2010 SHI YB, LIPSON SE, CHI DY, SPIELMANN HP, MONFORTE JA, HEARST JE. ChemInform Abstract: Applications of Psoralens as Probes of Nucleic Acid Structure and Function Cheminform. 22: no-no. DOI: 10.1002/chin.199116327  0.442
2009 Onono FO, Morgan MA, Spielmann HP, Andres DA, Scherr M, Venturini L, Dallman I, Ganser A, Reuter CW. A Novel Proteomic Approach to Define Leukemia Cell Resistance to Farnesyltransferase Inhibitors. Blood. 114: 3761-3761. DOI: 10.1182/Blood.V114.22.3761.3761  0.349
2008 Subramanian T, Liu S, Troutman JM, Andres DA, Spielmann HP. Protein farnesyltransferase-catalyzed isoprenoid transfer to peptide depends on lipid size and shape, not hydrophobicity. Chembiochem : a European Journal of Chemical Biology. 9: 2872-82. PMID 18985644 DOI: 10.1002/Cbic.200800248  0.724
2007 Troutman JM, Andres DA, Spielmann HP. Protein farnesyl transferase target selectivity is dependent upon peptide stimulated product release. Biochemistry. 46: 11299-309. PMID 17877368 DOI: 10.1021/Bi700513N  0.703
2007 Troutman JM, Subramanian T, Andres DA, Spielmann HP. Selective modification of CaaX peptides with ortho-substituted anilinogeranyl lipids by protein farnesyl transferase: competitive substrates and potent inhibitors from a library of farnesyl diphosphate analogues. Biochemistry. 46: 11310-21. PMID 17854205 DOI: 10.1021/Bi700516M  0.737
2006 Roberts MJ, Troutman JM, Chehade KA, Cha HC, Kao JP, Huang X, Zhan CG, Peterson YK, Subramanian T, Kamalakkannan S, Andres DA, Spielmann HP. Hydrophilic anilinogeranyl diphosphate prenyl analogues are Ras function inhibitors. Biochemistry. 45: 15862-72. PMID 17176109 DOI: 10.1021/BI061704+  0.735
2005 Nielsen KE, Spielmann HP. The structure of a mixed LNA/DNA:RNA duplex is driven by conformational coupling between LNA and deoxyribose residues as determined from 13C relaxation measurements. Journal of the American Chemical Society. 127: 15273-82. PMID 16248670 DOI: 10.1021/Ja051026Z  0.3
2005 Troutman JM, Roberts MJ, Andres DA, Spielmann HP. Tools to analyze protein farnesylation in cells. Bioconjugate Chemistry. 16: 1209-17. PMID 16173800 DOI: 10.1021/Bc050068+  0.701
2005 Subramanian T, Wang Z, Troutman JM, Andres DA, Spielmann HP. Directed library of anilinogeranyl analogues of farnesyl diphosphate via mixed solid- and solution-phase synthesis. Organic Letters. 7: 2109-12. PMID 15901146 DOI: 10.1021/Ol050386O  0.686
2004 Troutman JM, Chehade KA, Kiegiel K, Andres DA, Spielmann HP. Synthesis of acyloxymethyl ester prodrugs of the transferable protein farnesyl transferase substrate farnesyl methylenediphosphonate. Bioorganic & Medicinal Chemistry Letters. 14: 4979-82. PMID 15341963 DOI: 10.1016/J.Bmcl.2004.07.017  0.757
2004 Isaacs RJ, Spielmann HP. A model for initial DNA lesion recognition by NER and MMR based on local conformational flexibility. Dna Repair. 3: 455-64. PMID 15162792 DOI: 10.1016/J.Dnarep.2004.01.004  0.679
2004 Isaacs RJ, Spielmann HP. Insight into G[bond]T mismatch recognition using molecular dynamics with time-averaged restraints derived from NMR spectroscopy. Journal of the American Chemical Society. 126: 583-90. PMID 14719957 DOI: 10.1021/Ja037333R  0.684
2003 Minutolo F, Bertini S, Betti L, Di Bussolo V, Giannaccini G, Placanica G, Rapposelli S, Spielmann HP, Macchia M. Synthesis of aniline-type analogues of farnesyl diphosphate and their biological assays for prenyl protein transferase inhibitory activity. Farmaco (Società Chimica Italiana : 1989). 58: 1277-81. PMID 14630239 DOI: 10.1016/J.Farmac.2003.08.002  0.36
2002 Meier MS, Bergosh RG, Gallagher ME, Spielmann HP, Wang Z. Alkylation of dihydrofullerenes. The Journal of Organic Chemistry. 67: 5946-52. PMID 12182626 DOI: 10.1021/Jo020216E  0.32
2002 Chehade KA, Kiegiel K, Isaacs RJ, Pickett JS, Bowers KE, Fierke CA, Andres DA, Spielmann HP. Photoaffinity analogues of farnesyl pyrophosphate transferable by protein farnesyl transferase. Journal of the American Chemical Society. 124: 8206-19. PMID 12105898 DOI: 10.1021/Ja0124717  0.771
2002 Isaacs RJ, Rayens WS, Spielmann HP. Structural differences in the NOE-derived structure of G-T mismatched DNA relative to normal DNA are correlated with differences in (13)C relaxation-based internal dynamics. Journal of Molecular Biology. 319: 191-207. PMID 12051946 DOI: 10.1016/S0022-2836(02)00265-6  0.692
2001 Micali E, Chehade KA, Isaacs RJ, Andres DA, Spielmann HP. Protein farnesyltransferase isoprenoid substrate discrimination is dependent on isoprene double bonds and branched methyl groups. Biochemistry. 40: 12254-65. PMID 11591144 DOI: 10.1021/Bi011133F  0.76
2001 Isaacs RJ, Spielmann HP. NMR evidence for mechanical coupling of phosphate B(I)-B(II) transitions with deoxyribose conformational exchange in DNA. Journal of Molecular Biology. 311: 149-60. PMID 11469864 DOI: 10.1006/Jmbi.2001.4855  0.693
2001 Than C, Morimoto H, Williams PG, Chehade KA, Andres DA, Spielmann HP. Preparation, NMR characterization, and labeling reactions of tritiated triacetoxy sodium borohydride. The Journal of Organic Chemistry. 66: 3602-5. PMID 11348153 DOI: 10.1021/Jo005753I  0.745
2001 Isaacs RJ, Spielmann HP. Relationship of DNA structure to internal dynamics: correlation of helical parameters from NOE-based NMR solution structures of d(GCGTACGC)(2) and d(CGCTAGCG)(2) with (13)C order parameters implies conformational coupling in dinucleotide units. Journal of Molecular Biology. 307: 525-40. PMID 11254380 DOI: 10.1006/Jmbi.2001.4498  0.68
2000 Chehade KA, Spielmann HP. Facile and efficient synthesis of 4-azidotetrafluoroaniline: a new photoaffinity reagent. The Journal of Organic Chemistry. 65: 4949-53. PMID 10956477 DOI: 10.1021/Jo000402P  0.766
2000 Chehade KA, Andres DA, Morimoto H, Spielmann HP. Design and synthesis of a transferable farnesyl pyrophosphate analogue to Ras by protein farnesyltransferase. The Journal of Organic Chemistry. 65: 3027-33. PMID 10814193 DOI: 10.1021/Jo991735T  0.785
1996 Fagan PA, Spielmann HP, Sigurdsson S, Rink SM, Hopkins PB, Wemmer DE. An NMR study of [d(CGCGAATTCGCG)]2 containing an interstrand cross-link derived from a distamycin-pyrrole conjugate. Nucleic Acids Research. 24: 1566-73. PMID 8628693 DOI: 10.1093/Nar/24.8.1566  0.348
1995 Spielmann HP, Dwyer TJ, Sastry SS, Hearst JE, Wemmer DE. DNA structural reorganization upon conversion of a psoralen furan-side monoadduct to an interstrand cross-link: implications for DNA repair. Proceedings of the National Academy of Sciences of the United States of America. 92: 2345-9. PMID 7892269 DOI: 10.1073/Pnas.92.6.2345  0.507
1995 Spielmann HP, Chi DY, Hunt NG, Klein MP, Hearst JE. Spin-labeled psoralen probes for the study of DNA dynamics. Biochemistry. 34: 14801-14. PMID 7578089 DOI: 10.1021/bi00045a022  0.479
1995 Spielmann HP, Dwyer TJ, Hearst JE, Wemmer DE. Solution structures of psoralen monoadducted and cross-linked DNA oligomers by NMR spectroscopy and restrained molecular dynamics. Biochemistry. 34: 12937-53. PMID 7548052 DOI: 10.1021/Bi00040A004  0.492
1994 Sastry SS, Spielmann HP, Hoang QS, Phillips AM, Sancar A, Hearst JE. Laser-induced protein-DNA cross-links via psoralen furanoside monoadducts. [Erratum to document cited in CA119(3):23710w] Biochemistry. 33: 1616-1616. DOI: 10.1021/Bi00172A043  0.509
1993 Sastry SS, Spielmann HP, Hoang QS, Phillips AM, Sancar A, Hearst JE. Laser-induced protein-DNA cross-links via psoralen furanside monoadducts. Biochemistry. 32: 5526-38. PMID 8504073 DOI: 10.1021/Bi00072A006  0.502
1993 Sastry SS, Spielmann HP, Hearst JE. Psoralens and their application to the study of some molecular biological processes. Advances in Enzymology and Related Areas of Molecular Biology. 66: 85-148. PMID 8430517 DOI: 10.1002/9780470123126.ch3  0.404
1992 Spielmann HP, Sastry SS, Hearst JE. Methods for the large-scale synthesis of psoralen furan-side monoadducts and diadducts. Proceedings of the National Academy of Sciences of the United States of America. 89: 4514-8. PMID 1584785 DOI: 10.1073/Pnas.89.10.4514  0.47
1992 Sastry SS, Spielmann HP, Dwyer TJ, Wemmer DE, Hearst JE. Recent advances in the synthesis and structure determination of site specifically psoralen-modified DNA oligonucleotides. Journal of Photochemistry and Photobiology. B, Biology. 14: 65-79. PMID 1432385 DOI: 10.1016/1011-1344(92)85083-7  0.545
1988 Shi YB, Spielmann HP, Hearst JE. Base-catalyzed reversal of a psoralen-DNA cross-link. Biochemistry. 27: 5174-8. PMID 3167039 DOI: 10.1021/bi00414a034  0.496
1986 Spielmann HP, Kahn JD, Hearst JE. New methods for probing nucleic acids. Bioessays : News and Reviews in Molecular, Cellular and Developmental Biology. 5: 232-4. PMID 2434078 DOI: 10.1002/Bies.950050512  0.685
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