Scott A. Strobel, Ph.D. - Publications

Affiliations: 
Molecular Biochemistry and Biophysics Yale University, New Haven, CT 
Area:
RNA, Ribosome
Website:
http://medicine.yale.edu/mbb/faculty/scott_strobel.profile

169 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2021 Tausta SL, Berbasova T, Peverelli M, Strobel SA. The fluoride transporter FLUORIDE EXPORTER (FEX) is the major mechanism of tolerance to fluoride toxicity in plants. Plant Physiology. PMID 33744970 DOI: 10.1093/plphys/kiab131  0.36
2020 Johnston NR, Nallur S, Gordon PB, Smith KD, Strobel SA. Genome-Wide Identification of Genes Involved in General Acid Stress and Fluoride Toxicity in . Frontiers in Microbiology. 11: 1410. PMID 32670247 DOI: 10.3389/fmicb.2020.01410  1
2020 Adaku N, Park HB, Spakowicz DJ, Tiwari MK, Strobel SA, Crawford JM, Rogers FA. A DNA Repair Inhibitor Isolated from an Ecuadorian Fungal Endophyte Exhibits Synthetic Lethality in PTEN-Deficient Glioblastoma. Journal of Natural Products. PMID 32407116 DOI: 10.1021/acs.jnatprod.0c00012  0.72
2020 Hiller DA, Dunican BF, Nallur S, Li NS, Piccirilli JA, Strobel SA. The positively charged active site of the bacterial toxin RelE causes a large shift in the general base pKa. Biochemistry. PMID 32320214 DOI: 10.1021/acs.biochem.9b01047  0.56
2020 Torgerson CD, Hiller DA, Strobel SA. The asymmetry and cooperativity of tandem glycine riboswitch aptamers. Rna (New York, N.Y.). PMID 31992591 DOI: 10.1261/rna.073577.119  0.44
2018 Torgerson CD, Hiller DA, Stav S, Strobel SA. Gene regulation by a glycine riboswitch singlet uses a finely tuned energetic landscape for helical switching. Rna (New York, N.Y.). PMID 30237163 DOI: 10.1261/rna.067884.118  0.44
2017 Berbasova T, Nallur S, Sells T, Smith KD, Gordon PB, Tausta SL, Strobel SA. Fluoride export (FEX) proteins from fungi, plants and animals are 'single barreled' channels containing one functional and one vestigial ion pore. Plos One. 12: e0177096. PMID 28472134 DOI: 10.1371/journal.pone.0177096  1
2017 Hutchings ML, Alpha-Cobb CJ, Hiller DA, Berro J, Strobel SA. Mycofumigation Through Production of the Volatile DNA Methylating Agent N-methyl-N-nitrosoisobutyramide by Fungi in the Genus Muscodor. The Journal of Biological Chemistry. PMID 28283571 DOI: 10.1074/jbc.M117.779009  0.44
2016 Ruff KM, Muhammad A, McCown PJ, Breaker RR, Strobel SA. Singlet glycine riboswitches bind ligand as well as tandem riboswitches. Rna (New York, N.Y.). PMID 27659053 DOI: 10.1261/rna.057935.116  0.32
2016 de Sena Filho JG, Quin MB, Spakowicz DJ, Shaw JJ, Kucera K, Dunican B, Strobel SA, Schmidt-Dannert C. Genome of Diaporthe sp. provides insights into the potential inter-phylum transfer of a fungal sesquiterpenoid biosynthetic pathway. Fungal Biology. 120: 1050-63. PMID 27521636 DOI: 10.1016/j.funbio.2016.04.001  0.72
2016 Meehan RE, Torgerson CD, Gaffney BL, Jones RA, Strobel SA. Nuclease-resistant c-di-AMP derivatives that differentially recognize RNA and protein receptors. Biochemistry. PMID 26789423 DOI: 10.1021/acs.biochem.5b00965  1
2016 de Sena Filho JG, Quin MB, Spakowicz DJ, Shaw JJ, Kucera K, Dunican B, Strobel SA, Schmidt-Dannert C. Genome of Diaporthe sp. provides insights into the potential inter-phylum transfer of a fungal sesquiterpenoid biosynthetic pathway Fungal Biology. DOI: 10.1016/j.funbio.2016.04.001  0.36
2016 Kolařík M, Spakowicz DJ, Gazis R, Shaw J, Kubátová A, Nováková A, Chudíčková M, Forcina GC, Kang KW, Kelnarová I, Skaltsas D, Portero CE, Strobel SA, Narváez-Trujillo A. Biatriospora (Ascomycota: Pleosporales) is an ecologically diverse genus including facultative marine fungi and endophytes with biotechnological potential Plant Systematics and Evolution. 1-16. DOI: 10.1007/s00606-016-1350-2  0.36
2015 Rundell SM, Spakowicz DJ, Narváez-Trujillo A, Strobel SA. The Biological Diversity and Production of Volatile Organic Compounds by Stem-Inhabiting Endophytic Fungi of Ecuador. Journal of Fungi (Basel, Switzerland). 1: 384-396. PMID 29376917 DOI: 10.3390/jof1030384  0.72
2015 Patridge EV, Darnell A, Kucera K, Phillips GM, Bokesch HR, Gustafson KR, Spakowicz DJ, Zhou L, Hungerford WM, Plummer M, Hoyer D, Narváez-Trujillo A, Phillips AJ, Strobel SA. Pyrrolocin A, a 3-Decalinoyltetramic Acid with Selective Biological Activity, Isolated from Amazonian Cultures of the Novel Endophyte Diaporthales sp. E6927E. Natural Product Communications. 10: 1649-54. PMID 26669095  1
2015 Forcina GC, Castro A, Bokesch HR, Spakowicz DJ, Legaspi ME, Kucera K, Villota S, Narváez-Trujillo A, McMahon JB, Gustafson KR, Strobel SA. Stelliosphaerols A and B, Sesquiterpene-Polyol Conjugates from an Ecuadorian Fungal Endophyte. Journal of Natural Products. PMID 26651879 DOI: 10.1021/acs.jnatprod.5b00749  1
2015 Dunican BF, Hiller DA, Strobel SA. Transition State Charge Stabilization and Acid-Base Catalysis of mRNA Cleavage by the Endoribonuclease RelE. Biochemistry. PMID 26535789 DOI: 10.1021/acs.biochem.5b00866  1
2015 Smith KD, Gordon PB, Rivetta A, Allen KE, Berbasova T, Slayman C, Strobel SA. Yeast FEX1 is a Constitutively Expressed Fluoride Channel with Functional Asymmetry of its Two Homologous Domains. The Journal of Biological Chemistry. PMID 26055717 DOI: 10.1074/jbc.M115.651976  1
2015 Spakowicz DJ, Strobel SA. Biosynthesis of hydrocarbons and volatile organic compounds by fungi: bioengineering potential. Applied Microbiology and Biotechnology. 99: 4943-51. PMID 25957494 DOI: 10.1007/s00253-015-6641-y  1
2015 Yin ES, Rakhmankulova M, Kucera K, de Sena Filho JG, Portero CE, Narváez-Trujillo A, Holley SA, Strobel SA. Fusaric acid induces a notochord malformation in zebrafish via copper chelation. Biometals : An International Journal On the Role of Metal Ions in Biology, Biochemistry, and Medicine. 28: 783-9. PMID 25913293 DOI: 10.1007/s10534-015-9855-7  1
2015 Shaw JJ, Spakowicz DJ, Dalal RS, Davis JH, Lehr NA, Dunican BF, Orellana EA, Narváez-Trujillo A, Strobel SA. Biosynthesis and genomic analysis of medium-chain hydrocarbon production by the endophytic fungal isolate Nigrograna mackinnonii E5202H. Applied Microbiology and Biotechnology. 99: 3715-28. PMID 25672844 DOI: 10.1007/s00253-014-6206-5  1
2015 Shaw JJ, Berbasova T, Sasaki T, Jefferson-George K, Spakowicz DJ, Dunican BF, Portero CE, Narváez-Trujillo A, Strobel SA. Identification of a fungal 1,8-cineole synthase from Hypoxylon sp. with specificity determinants in common with the plant synthases. The Journal of Biological Chemistry. 290: 8511-26. PMID 25648891 DOI: 10.1074/jbc.M114.636159  1
2015 Alpha CJ, Campos M, Jacobs-Wagner C, Strobel SA. Mycofumigation by the volatile organic compound-producing Fungus Muscodor albus induces bacterial cell death through DNA damage. Applied and Environmental Microbiology. 81: 1147-56. PMID 25452287 DOI: 10.1128/AEM.03294-14  1
2014 Ruff KM, Strobel SA. Ligand binding by the tandem glycine riboswitch depends on aptamer dimerization but not double ligand occupancy. Rna (New York, N.Y.). 20: 1775-88. PMID 25246650 DOI: 10.1261/rna.047266.114  1
2013 Griffin MA, Davis JH, Strobel SA. Bacterial toxin RelE: a highly efficient ribonuclease with exquisite substrate specificity using atypical catalytic residues. Biochemistry. 52: 8633-42. PMID 24251350 DOI: 10.1021/bi401325c  1
2013 Strobel SA. Biochemistry: Metal ghosts in the splicing machine. Nature. 503: 201-2. PMID 24196709 DOI: 10.1038/nature12705  1
2013 Santiago M, Strobel S. Thin layer chromatography. Methods in Enzymology. 533: 303-24. PMID 24182936 DOI: 10.1016/B978-0-12-420067-8.00024-6  1
2013 Li S, Smith KD, Davis JH, Gordon PB, Breaker RR, Strobel SA. Eukaryotic resistance to fluoride toxicity mediated by a widespread family of fluoride export proteins. Proceedings of the National Academy of Sciences of the United States of America. 110: 19018-23. PMID 24173035 DOI: 10.1073/pnas.1310439110  1
2013 Baraban EG, Morin JB, Phillips GM, Phillips AJ, Strobel SA, Handelsman J. Xyolide, a bioactive nonenolide from an Amazonian endophytic fungus, Xylaria feejeensis. Tetrahedron Letters. 54: 4058-4060. PMID 23913990 DOI: 10.1016/j.tetlet.2013.05.093  1
2013 Shanahan CA, Gaffney BL, Jones RA, Strobel SA. Identification of c-di-GMP derivatives resistant to an EAL domain phosphodiesterase. Biochemistry. 52: 365-77. PMID 23256840 DOI: 10.1021/bi301510v  1
2012 Hanauer DI, Frederick J, Fotinakes B, Strobel SA. Linguistic analysis of project ownership for undergraduate research experiences. Cbe Life Sciences Education. 11: 378-85. PMID 23222833 DOI: 10.1187/cbe.12-04-0043  1
2012 Bascom-Slack CA, Arnold AE, Strobel SA. IBI series winner. Student-directed discovery of the plant microbiome and its products. Science (New York, N.Y.). 338: 485-6. PMID 23112324 DOI: 10.1126/science.1215227  1
2012 Shanahan CA, Strobel SA. The bacterial second messenger c-di-GMP: probing interactions with protein and RNA binding partners using cyclic dinucleotide analogs. Organic & Biomolecular Chemistry. 10: 9113-29. PMID 23108253 DOI: 10.1039/c2ob26724a  1
2012 Gianoulis TA, Griffin MA, Spakowicz DJ, Dunican BF, Alpha CJ, Sboner A, Sismour AM, Kodira C, Egholm M, Church GM, Gerstein MB, Strobel SA. Genomic analysis of the hydrocarbon-producing, cellulolytic, endophytic fungus Ascocoryne sarcoides. Plos Genetics. 8: e1002558. PMID 22396667 DOI: 10.1371/journal.pgen.1002558  0.72
2012 Smith KD, Lipchock SV, Strobel SA. Structural and biochemical characterization of linear dinucleotide analogues bound to the c-di-GMP-I aptamer. Biochemistry. 51: 425-32. PMID 22148472 DOI: 10.1021/bi2016662  1
2012 Kingery DA, Strobel SA. Analysis of enzymatic transacylase Brønsted studies with application to the ribosome. Accounts of Chemical Research. 45: 495-503. PMID 22122380 DOI: 10.1021/ar100162b  1
2011 Anderson WA, Amasino RM, Ares M, Banerjee U, Bartel B, Corces VG, Drennan CL, Elgin SC, Epstein IR, Fanning E, Guillette LJ, Handelsman J, Hatfull GF, Hoy RR, Kelley D, ... ... Strobel SA, et al. Competencies: a cure for pre-med curriculum. Science (New York, N.Y.). 334: 760-1. PMID 22076362 DOI: 10.1126/science.334.6057.760-b  1
2011 Carrasco N, Hiller DA, Strobel SA. Minimal transition state charge stabilization of the oxyanion during peptide bond formation by the ribosome. Biochemistry. 50: 10491-8. PMID 22035282 DOI: 10.1021/bi201290s  1
2011 Hiller DA, Strobel SA. The chemical versatility of RNA. Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences. 366: 2929-35. PMID 21930584 DOI: 10.1098/rstb.2011.0143  1
2011 Shanahan CA, Gaffney BL, Jones RA, Strobel SA. Differential analogue binding by two classes of c-di-GMP riboswitches. Journal of the American Chemical Society. 133: 15578-92. PMID 21838307 DOI: 10.1021/ja204650q  1
2011 Davis JH, Dunican BF, Strobel SA. glmS Riboswitch binding to the glucosamine-6-phosphate α-anomer shifts the pKa toward neutrality. Biochemistry. 50: 7236-42. PMID 21770472 DOI: 10.1021/bi200471c  1
2011 Hiller DA, Singh V, Zhong M, Strobel SA. A two-step chemical mechanism for ribosome-catalysed peptide bond formation. Nature. 476: 236-9. PMID 21765427 DOI: 10.1038/nature10248  1
2011 Russell JR, Huang J, Anand P, Kucera K, Sandoval AG, Dantzler KW, Hickman D, Jee J, Kimovec FM, Koppstein D, Marks DH, Mittermiller PA, Núñez SJ, Santiago M, Townes MA, ... ... Strobel SA, et al. Biodegradation of polyester polyurethane by endophytic fungi. Applied and Environmental Microbiology. 77: 6076-84. PMID 21764951 DOI: 10.1128/AEM.00521-11  1
2011 Zaher HS, Shaw JJ, Strobel SA, Green R. The 2'-OH group of the peptidyl-tRNA stabilizes an active conformation of the ribosomal PTC. The Embo Journal. 30: 2445-53. PMID 21552203 DOI: 10.1038/emboj.2011.142  1
2011 Smith KD, Shanahan CA, Moore EL, Simon AC, Strobel SA. Structural basis of differential ligand recognition by two classes of bis-(3'-5')-cyclic dimeric guanosine monophosphate-binding riboswitches. Proceedings of the National Academy of Sciences of the United States of America. 108: 7757-62. PMID 21518891 DOI: 10.1073/pnas.1018857108  1
2011 Butler EB, Xiong Y, Wang J, Strobel SA. Structural basis of cooperative ligand binding by the glycine riboswitch. Chemistry & Biology. 18: 293-8. PMID 21439473 DOI: 10.1016/j.chembiol.2011.01.013  1
2011 Smith KD, Strobel SA. Interactions of the c-di-GMP riboswitch with its second messenger ligand. Biochemical Society Transactions. 39: 647-51. PMID 21428955 DOI: 10.1042/BST0390647  1
2011 Anderson WA, Banerjee U, Drennan CL, Elgin SC, Epstein IR, Handelsman J, Hatfull GF, Losick R, O'Dowd DK, Olivera BM, Strobel SA, Walker GC, Warner IM. Science education. Changing the culture of science education at research universities. Science (New York, N.Y.). 331: 152-3. PMID 21233371 DOI: 10.1126/science.1198280  1
2011 Erion TV, Strobel SA. Identification of a tertiary interaction important for cooperative ligand binding by the glycine riboswitch. Rna (New York, N.Y.). 17: 74-84. PMID 21098652 DOI: 10.1261/rna.2271511  1
2011 Hunt KA, Mallette N, Carlson RP, Smooke M, Strobel G, Strobel S, Peyton B. Fungal processes for direct bioconversion of cellulose to hydrocarbons 11aiche - 2011 Aiche Annual Meeting, Conference Proceedings 1
2010 Griffin MA, Spakowicz DJ, Gianoulis TA, Strobel SA. Volatile organic compound production by organisms in the genus Ascocoryne and a re-evaluation of myco-diesel production by NRRL 50072. Microbiology (Reading, England). 156: 3814-29. PMID 20705658 DOI: 10.1099/mic.0.041327-0  1
2010 Smith KD, Lipchock SV, Livingston AL, Shanahan CA, Strobel SA. Structural and biochemical determinants of ligand binding by the c-di-GMP riboswitch . Biochemistry. 49: 7351-9. PMID 20690679 DOI: 10.1021/bi100671e  1
2010 Suydam IT, Levandoski SD, Strobel SA. Catalytic importance of a protonated adenosine in the hairpin ribozyme active site. Biochemistry. 49: 3723-32. PMID 20373826 DOI: 10.1021/bi100234v  1
2010 Hiller DA, Zhong M, Singh V, Strobel SA. Transition states of uncatalyzed hydrolysis and aminolysis reactions of a ribosomal P-site substrate determined by kinetic isotope effects. Biochemistry. 49: 3868-78. PMID 20359191 DOI: 10.1021/bi901458x  1
2010 Antonioli AH, Cochrane JC, Lipchock SV, Strobel SA. Plasticity of the RNA kink turn structural motif. Rna (New York, N.Y.). 16: 762-8. PMID 20145044 DOI: 10.1261/rna.1883810  1
2010 Strobel G, Tomsheck A, Geary B, Spakowicz D, Strobel S, Mattner S, Mann R. Endophyte Strain NRRL 50072 producing volatile organics is a species of Ascocoryne Mycology. 1: 187-194. DOI: 10.1080/21501203.2010.510122  1
2010 Kwon M, Strobel SA. Chemical basis of glycine riboswitch cooperativity (RNA (2008) 14, (25-34)) Rna. 16: 2291.  1
2009 Suydam IT, Strobel SA. Nucleotide analog interference mapping. Methods in Enzymology. 468: 3-30. PMID 20946762 DOI: 10.1016/S0076-6879(09)68001-0  1
2009 Smith KD, Lipchock SV, Ames TD, Wang J, Breaker RR, Strobel SA. Structural basis of ligand binding by a c-di-GMP riboswitch. Nature Structural & Molecular Biology. 16: 1218-23. PMID 19898477 DOI: 10.1038/nsmb.1702  1
2009 Bascom-Slack CA, Ma C, Moore E, Babbs B, Fenn K, Greene JS, Hann BD, Keehner J, Kelley-Swift EG, Kembaiyan V, Lee SJ, Li P, Light DY, Lin EH, Schorn MA, ... ... Strobel SA, et al. Multiple, novel biologically active endophytic actinomycetes isolated from upper Amazonian rainforests. Microbial Ecology. 58: 374-83. PMID 19252940 DOI: 10.1007/s00248-009-9494-z  1
2009 Cochrane JC, Lipchock SV, Smith KD, Strobel SA. Structural and chemical basis for glucosamine 6-phosphate binding and activation of the glmS ribozyme. Biochemistry. 48: 3239-46. PMID 19228039 DOI: 10.1021/bi802069p  1
2009 Lee SJ, Strobel GA, Eisenman K, Geary B, Vargas PN, Strobel SA. Aurosphaeria, a novel coelomycetous genus Mycotaxon. 107: 463-472.  1
2008 Suydam IT, Strobel SA. Fluorine substituted adenosines as probes of nucleobase protonation in functional RNAs. Journal of the American Chemical Society. 130: 13639-48. PMID 18803382 DOI: 10.1021/ja803336y  1
2008 Smith SA, Tank DC, Boulanger LA, Bascom-Slack CA, Eisenman K, Kingery D, Babbs B, Fenn K, Greene JS, Hann BD, Keehner J, Kelley-Swift EG, Kembaiyan V, Lee SJ, Li P, ... ... Strobel SA, et al. Bioactive endophytes warrant intensified exploration and conservation. Plos One. 3: e3052. PMID 18725962 DOI: 10.1371/journal.pone.0003052  1
2008 Huang KS, Carrasco N, Pfund E, Strobel SA. Transition state chirality and role of the vicinal hydroxyl in the ribosomal peptidyl transferase reaction. Biochemistry. 47: 8822-7. PMID 18672893 DOI: 10.1021/bi800299u  1
2008 Cochrane JC, Strobel SA. Catalytic strategies of self-cleaving ribozymes. Accounts of Chemical Research. 41: 1027-35. PMID 18652494 DOI: 10.1021/ar800050c  1
2008 Kingery DA, Pfund E, Voorhees RM, Okuda K, Wohlgemuth I, Kitchen DE, Rodnina MV, Strobel SA. An uncharged amine in the transition state of the ribosomal peptidyl transfer reaction. Chemistry & Biology. 15: 493-500. PMID 18482701 DOI: 10.1016/j.chembiol.2008.04.005  1
2008 Cochrane JC, Strobel SA. Riboswitch effectors as protein enzyme cofactors. Rna (New York, N.Y.). 14: 993-1002. PMID 18430893 DOI: 10.1261/rna.908408  1
2008 Lipchock SV, Strobel SA. A relaxed active site after exon ligation by the group I intron. Proceedings of the National Academy of Sciences of the United States of America. 105: 5699-704. PMID 18408159 DOI: 10.1073/pnas.0712016105  1
2008 Zhong M, Strobel SA. Synthesis of isotopically labeled P-site substrates for the ribosomal peptidyl transferase reaction. The Journal of Organic Chemistry. 73: 603-11. PMID 18081346 DOI: 10.1021/jo702070m  1
2008 Kwon M, Strobel SA. Chemical basis of glycine riboswitch cooperativity. Rna (New York, N.Y.). 14: 25-34. PMID 18042658 DOI: 10.1261/rna.771608  1
2007 Strobel SA, Cochrane JC. RNA catalysis: ribozymes, ribosomes, and riboswitches. Current Opinion in Chemical Biology. 11: 636-43. PMID 17981494 DOI: 10.1016/j.cbpa.2007.09.010  1
2007 Stahley MR, Adams PL, Wang J, Strobel SA. Structural metals in the group I intron: a ribozyme with a multiple metal ion core. Journal of Molecular Biology. 372: 89-102. PMID 17612557 DOI: 10.1016/j.jmb.2007.06.026  1
2007 Strobel SA, Strobel GA. Plant endophytes as a platform for discovery-based undergraduate science education. Nature Chemical Biology. 3: 356-9. PMID 17576416 DOI: 10.1038/nchembio0707-356  1
2007 Anderson RM, Kwon M, Strobel SA. Toward ribosomal RNA catalytic activity in the absence of protein. Journal of Molecular Evolution. 64: 472-83. PMID 17417708 DOI: 10.1007/s00239-006-0211-y  1
2007 Cochrane JC, Lipchock SV, Strobel SA. Structural investigation of the GlmS ribozyme bound to Its catalytic cofactor. Chemistry & Biology. 14: 97-105. PMID 17196404 DOI: 10.1016/j.chembiol.2006.12.005  1
2007 Weinger JS, Strobel SA. Exploring the mechanism of protein synthesis with modified substrates and novel intermediate mimics. Blood Cells, Molecules & Diseases. 38: 110-6. PMID 17188006 DOI: 10.1016/j.bcmd.2006.11.002  1
2006 Gill ML, Strobel SA, Loria JP. Crystallization and characterization of the thallium form of the Oxytricha nova G-quadruplex. Nucleic Acids Research. 34: 4506-14. PMID 16945956 DOI: 10.1093/nar/gkl616  1
2006 Stahley MR, Strobel SA. RNA splicing: group I intron crystal structures reveal the basis of splice site selection and metal ion catalysis. Current Opinion in Structural Biology. 16: 319-26. PMID 16697179 DOI: 10.1016/j.sbi.2006.04.005  1
2006 Weinger JS, Strobel SA. Participation of the tRNA A76 hydroxyl groups throughout translation. Biochemistry. 45: 5939-48. PMID 16681365 DOI: 10.1021/bi060183n  1
2006 Huang KS, Weinger JS, Butler EB, Strobel SA. Regiospecificity of the peptidyl tRNA ester within the ribosomal P site. Journal of the American Chemical Society. 128: 3108-9. PMID 16522067 DOI: 10.1021/ja0554099  1
2006 Zhong M, Strobel SA. Synthesis of the ribosomal P-site substrate CCA-pcb. Organic Letters. 8: 55-8. PMID 16381566 DOI: 10.1021/ol052484f  1
2006 Strobel SA. Intron splicing: A general two-metal mechanism for RNA and protein catalysts Biochemist. 28: 21-24.  1
2005 Strobel SA. Ribonucleic general acid. Nature Chemical Biology. 1: 5-6. PMID 16407982 DOI: 10.1038/nchembio0605-5  1
2005 Schmeing TM, Huang KS, Strobel SA, Steitz TA. An induced-fit mechanism to promote peptide bond formation and exclude hydrolysis of peptidyl-tRNA. Nature. 438: 520-4. PMID 16306996 DOI: 10.1038/nature04152  1
2005 Gill ML, Strobel SA, Loria JP. 205Tl NMR methods for the characterization of monovalent cation binding to nucleic acids. Journal of the American Chemical Society. 127: 16723-32. PMID 16305263 DOI: 10.1021/ja055358f  1
2005 Schmeing TM, Huang KS, Kitchen DE, Strobel SA, Steitz TA. Structural insights into the roles of water and the 2' hydroxyl of the P site tRNA in the peptidyl transferase reaction. Molecular Cell. 20: 437-48. PMID 16285925 DOI: 10.1016/j.molcel.2005.09.006  1
2005 Stahley MR, Strobel SA. Structural evidence for a two-metal-ion mechanism of group I intron splicing. Science (New York, N.Y.). 309: 1587-90. PMID 16141079 DOI: 10.1126/science.1114994  1
2005 Szewczak LB, Gabrielsen JS, Degregorio SJ, Strobel SA, Steitz JA. Molecular basis for RNA kink-turn recognition by the h15.5K small RNP protein. Rna (New York, N.Y.). 11: 1407-19. PMID 16120832 DOI: 10.1261/rna.2830905  1
2005 Okuda K, Seila AC, Strobel SA. Uncovering the enzymatic pKa of the ribosomal peptidyl transferase reaction utilizing a fluorinated puromycin derivative. Biochemistry. 44: 6675-84. PMID 15850401 DOI: 10.1021/bi047419c  1
2005 Seila AC, Okuda K, Núñez S, Seila AF, Strobel SA. Kinetic isotope effect analysis of the ribosomal peptidyl transferase reaction. Biochemistry. 44: 4018-27. PMID 15751978 DOI: 10.1021/bi047742f  1
2005 Strobel SA, Muir TW. Biopolymers: Exploring biological function through chemical manipulation of biopolymers Current Opinion in Chemical Biology. 9: 545-547. DOI: 10.1016/j.cbpa.2005.10.017  1
2004 Cochrane JC, Strobel SA. Probing RNA structure and function by nucleotide analog interference mapping. Current Protocols in Nucleic Acid Chemistry / Edited by Serge L. Beaucage ... [Et Al.]. Unit 6.9. PMID 18428931 DOI: 10.1002/0471142700.nc0609s17  1
2004 Adams PL, Stahley MR, Gill ML, Kosek AB, Wang J, Strobel SA. Crystal structure of a group I intron splicing intermediate. Rna (New York, N.Y.). 10: 1867-87. PMID 15547134 DOI: 10.1261/rna.7140504  1
2004 Strobel SA, Adams PL, Stahley MR, Wang J. RNA kink turns to the left and to the right. Rna (New York, N.Y.). 10: 1852-4. PMID 15547133 DOI: 10.1261/rna.7141504  1
2004 Weinger JS, Parnell KM, Dorner S, Green R, Strobel SA. Substrate-assisted catalysis of peptide bond formation by the ribosome. Nature Structural & Molecular Biology. 11: 1101-6. PMID 15475967 DOI: 10.1038/nsmb841  1
2004 Hesslein AE, Katunin VI, Beringer M, Kosek AB, Rodnina MV, Strobel SA. Exploration of the conserved A+C wobble pair within the ribosomal peptidyl transferase center using affinity purified mutant ribosomes. Nucleic Acids Research. 32: 3760-70. PMID 15256541 DOI: 10.1093/nar/gkh672  1
2004 Adams PL, Stahley MR, Kosek AB, Wang J, Strobel SA. Crystal structure of a self-splicing group I intron with both exons. Nature. 430: 45-50. PMID 15175762 DOI: 10.1038/nature02642  1
2004 Weinger JS, Kitchen D, Scaringe SA, Strobel SA, Muth GW. Solid phase synthesis and binding affinity of peptidyl transferase transition state mimics containing 2'-OH at P-site position A76. Nucleic Acids Research. 32: 1502-11. PMID 14999092 DOI: 10.1093/nar/gkh311  1
2004 Okuda K, Seila AC, Strobel SA. Synthesis of isotopically labeled puromycin derivatives for kinetic isotope effect analysis of ribosome catalyzed peptide bond formation Tetrahedron. 60: 12101-12112. DOI: 10.1016/j.tet.2004.10.023  1
2003 Parnell KM, Strobel SA. HIS & HERS, magic magnesium and the ballet of protein synthesis. Current Opinion in Chemical Biology. 7: 528-33. PMID 14580554 DOI: 10.1016/j.cbpa.2003.08.003  1
2003 Strobel SA, Jones FD, Oyelere AK, Ryder SP. Biochemical detection of adenosine and cytidine ionization within RNA by interference analysis. Nucleic Acids Research. Supplement (2001). 229-30. PMID 14510464  1
2003 Cochrane JC, Batey RT, Strobel SA. Quantitation of free energy profiles in RNA-ligand interactions by nucleotide analog interference mapping. Rna (New York, N.Y.). 9: 1282-9. PMID 13130142 DOI: 10.1261/rna.5102803  1
2003 Cho HD, Oyelere AK, Strobel SA, Weiner AM. Use of nucleotide analogs by class I and class II CCA-adding enzymes (tRNA nucleotidyltransferase): deciphering the basis for nucleotide selection. Rna (New York, N.Y.). 9: 970-81. PMID 12869708 DOI: 10.1261/rna.2110903  1
2003 Jones FD, Strobel SA. Ionization of a critical adenosine residue in the neurospora Varkud Satellite ribozyme active site. Biochemistry. 42: 4265-76. PMID 12680781 DOI: 10.1021/bi020707t  1
2002 Strobel SA. Biochemical identification of A-minor motifs within RNA tertiary structure by interference analysis. Biochemical Society Transactions. 30: 1126-31. PMID 12440988 DOI: 10.1042/  1
2002 Szewczak LB, DeGregorio SJ, Strobel SA, Steitz JA. Exclusive interaction of the 15.5 kD protein with the terminal box C/D motif of a methylation guide snoRNP. Chemistry & Biology. 9: 1095-107. PMID 12401494 DOI: 10.1016/S1074-5521(02)00239-9  1
2002 Katunin VI, Muth GW, Strobel SA, Wintermeyer W, Rodnina MV. Important contribution to catalysis of peptide bond formation by a single ionizing group within the ribosome. Molecular Cell. 10: 339-46. PMID 12191479 DOI: 10.1016/S1097-2765(02)00566-X  1
2002 Parnell KM, Seila AC, Strobel SA. Evidence against stabilization of the transition state oxyanion by a pKa-perturbed RNA base in the peptidyl transferase center. Proceedings of the National Academy of Sciences of the United States of America. 99: 11658-63. PMID 12185248 DOI: 10.1073/pnas.182210099  1
2002 Soukup JK, Minakawa N, Matsuda A, Strobel SA. Identification of A-minor tertiary interactions within a bacterial group I intron active site by 3-deazaadenosine interference mapping. Biochemistry. 41: 10426-38. PMID 12173929 DOI: 10.1021/bi020265l  1
2002 Oyelere AK, Kardon JR, Strobel SA. pK(a) perturbation in genomic Hepatitis Delta Virus ribozyme catalysis evidenced by nucleotide analogue interference mapping. Biochemistry. 41: 3667-75. PMID 11888283 DOI: 10.1021/bi011816v  1
2002 Ryder SP, Strobel SA. Comparative analysis of hairpin ribozyme structures and interference data. Nucleic Acids Research. 30: 1287-91. PMID 11884625  1
2002 Szewczak AA, Kosek AB, Piccirilli JA, Strobel SA. Identification of an active site ligand for a group I ribozyme catalytic metal ion. Biochemistry. 41: 2516-25. PMID 11851398 DOI: 10.1021/bi011973u  1
2002 Schmeing TM, Seila AC, Hansen JL, Freeborn B, Soukup JK, Scaringe SA, Strobel SA, Moore PB, Steitz TA. A pre-translocational intermediate in protein synthesis observed in crystals of enzymatically active 50S subunits. Nature Structural Biology. 9: 225-30. PMID 11828326 DOI: 10.1038/nsb758  0.88
2001 Strobel SA, Muth GW, Chen L. Exploring the mechanism of the peptidyl transfer reaction by chemical footprinting. Cold Spring Harbor Symposia On Quantitative Biology. 66: 109-17. PMID 12762013  1
2001 Jones FD, Ryder SP, Strobel SA. An efficient ligation reaction promoted by a Varkud Satellite ribozyme with extended 5'- and 3'-termini. Nucleic Acids Research. 29: 5115-20. PMID 11812844  1
2001 Oyelere AK, Strobel SA. Site specific incorporation of 6-azauridine into the genomic HDV ribozyme active site. Nucleosides, Nucleotides & Nucleic Acids. 20: 1851-8. PMID 11719998 DOI: 10.1081/NCN-100107196  1
2001 Ryder SP, Oyelere AK, Padilla JL, Klostermeier D, Millar DP, Strobel SA. Investigation of adenosine base ionization in the hairpin ribozyme by nucleotide analog interference mapping. Rna (New York, N.Y.). 7: 1454-63. PMID 11680850  1
2001 Muth GW, Chen L, Kosek AB, Strobel SA. pH-dependent conformational flexibility within the ribosomal peptidyl transferase center. Rna (New York, N.Y.). 7: 1403-15. PMID 11680845  1
2001 Strobel SA. Repopulating the RNA world. Nature. 411: 1003-6. PMID 11429582 DOI: 10.1038/35082661  1
2001 Strobel SA, Ryder SP. Biological catalysis. The hairpin's turn. Nature. 410: 761-3. PMID 11298426 DOI: 10.1038/35071209  1
2001 Basu S, Strobel SA. Biochemical detection of monovalent metal ion binding sites within RNA. Methods (San Diego, Calif.). 23: 264-75. PMID 11243839 DOI: 10.1006/meth.2000.1137  1
2001 Strobel SA. Methods: Editorial Methods. 23: 199-200. DOI: 10.1006/meth.2000.1130  1
2000 Strauss-Soukup JK, Strobel SA. A chemical phylogeny of group I introns based upon interference mapping of a bacterial ribozyme. Journal of Molecular Biology. 302: 339-58. PMID 10970738 DOI: 10.1006/jmbi.2000.4056  1
2000 Muth GW, Ortoleva-Donnelly L, Strobel SA. A single adenosine with a neutral pKa in the ribosomal peptidyl transferase center. Science (New York, N.Y.). 289: 947-50. PMID 10937997 DOI: 10.1126/science.289.5481.947  1
2000 Ryder SP, Ortoleva-Donnelly L, Kosek AB, Strobel SA. Chemical probing of RNA by nucleotide analog interference mapping. Methods in Enzymology. 317: 92-109. PMID 10829274  1
2000 Basu S, Szewczak AA, Cocco M, Strobel SA. Direct detection of monovalent metal ion binding to a DNA G-quartet by 205Tl NMR [13] Journal of the American Chemical Society. 122: 3240-3241. DOI: 10.1021/ja993614g  1
2000 Oyelere AK, Strobel SA. Biochemical detection of cytidine protonation within RNA Journal of the American Chemical Society. 122: 10259-10267. DOI: 10.1021/ja001918t  1
1999 Basu S, Strobel SA. Thiophilic metal ion rescue of phosphorothioate interference within the Tetrahymena ribozyme P4-P6 domain. Rna (New York, N.Y.). 5: 1399-407. PMID 10580468 DOI: 10.1017/S135583829999115X  1
1999 Szewczak AA, Ortoleva-Donnelly L, Zivarts MV, Oyelere AK, Kazantsev AV, Strobel SA. An important base triple anchors the substrate helix recognition surface within the Tetrahymena ribozyme active site. Proceedings of the National Academy of Sciences of the United States of America. 96: 11183-8. PMID 10500151 DOI: 10.1073/pnas.96.20.11183  1
1999 Ryder SP, Strobel SA. Nucleotide analog interference mapping of the hairpin ribozyme: implications for secondary and tertiary structure formation. Journal of Molecular Biology. 291: 295-311. PMID 10438622 DOI: 10.1006/jmbi.1999.2959  1
1999 Strobel SA. A chemogenetic approach to RNA function/structure analysis. Current Opinion in Structural Biology. 9: 346-52. PMID 10361087 DOI: 10.1016/S0959-440X(99)80046-3  1
1999 Ryder SP, Strobel SA. Nucleotide analog interference mapping. Methods (San Diego, Calif.). 18: 38-50. PMID 10208815 DOI: 10.1006/meth.1999.0755  1
1999 Strobel SA, Ortoleva-Donnelly L. A hydrogen-bonding triad stabilizes the chemical transition state of a group I ribozyme. Chemistry & Biology. 6: 153-65. PMID 10074469 DOI: 10.1016/S1074-5521(99)89007-3  1
1999 Siew D, Zahler NH, Cassano AG, Strobel SA, Harris ME. Identification of adenosine functional groups involved in substrate binding by the ribonuclease P ribozyme. Biochemistry. 38: 1873-83. PMID 10026268 DOI: 10.1021/bi982329r  1
1998 Szewczak AA, Ortoleva-Donnelly L, Ryder SP, Moncoeur E, Strobel SA. A minor groove RNA triple helix within the catalytic core of a group I intron. Nature Structural Biology. 5: 1037-42. PMID 9846872 DOI: 10.1038/4146  1
1998 Strobel SA. Ribozyme chemogenetics. Biopolymers. 48: 65-81. PMID 9846125 DOI: 10.1002/(SICI)1097-0282(1998)48:1<65::AID-BIP7>3.0.CO;2-D  1
1998 Basu S, Rambo RP, Strauss-Soukup J, Cate JH, Ferré-D'Amaré AR, Strobel SA, Doudna JA. A specific monovalent metal ion integral to the AA platform of the RNA tetraloop receptor. Nature Structural Biology. 5: 986-92. PMID 9808044 DOI: 10.1038/2960  1
1998 Ortoleva-Donnelly L, Kronman M, Strobel SA. Identifying RNA minor groove tertiary contacts by nucleotide analogue interference mapping with N2-methylguanosine. Biochemistry. 37: 12933-42. PMID 9737873 DOI: 10.1021/bi980723j  1
1998 Rife JP, Cheng CS, Moore PB, Strobel SA. N 2-methylguanosine is iso-energetic with guanosine in RNA duplexes and GNRA tetraloops. Nucleic Acids Research. 26: 3640-4. PMID 9685477 DOI: 10.1093/nar/26.16.3640  1
1998 Ortoleva-Donnelly L, Szewczak AA, Gutell RR, Strobel SA. The chemical basis of adenosine conservation throughout the Tetrahymena ribozyme. Rna (New York, N.Y.). 4: 498-519. PMID 9582093 DOI: 10.1017/S1355838298980086  1
1998 Strobel SA, Ortoleva-Donnelly L, Ryder SP, Cate JH, Moncoeur E. Complementary sets of noncanonical base pairs mediate RNA helix packing in the group I intron active site. Nature Structural Biology. 5: 60-6. PMID 9437431 DOI: 10.1038/nsb0198-60  1
1998 Rife JP, Cheng CS, Moore PB, Strobel SA. The synthesis of RNA containing the modified nucleotides N2- methylguanosine and N6,N6-dimethyladenosine Nucleosides and Nucleotides. 17: 2281-2288.  1
1997 Strobel SA, Doudna JA. RNA seeing double: close-packing of helices in RNA tertiary structure. Trends in Biochemical Sciences. 22: 262-6. PMID 9255068 DOI: 10.1016/S0968-0004(97)01056-6  1
1997 Strobel SA, Shetty K. Defining the chemical groups essential for Tetrahymena group I intron function by nucleotide analog interference mapping. Proceedings of the National Academy of Sciences of the United States of America. 94: 2903-8. PMID 9096319 DOI: 10.1073/pnas.94.7.2903  1
1996 Query CC, Strobel SA, Sharp PA. Three recognition events at the branch-site adenine. The Embo Journal. 15: 1392-402. PMID 8635472  1
1996 Strobel SA, Cech TR. Exocyclic amine of the conserved G.U pair at the cleavage site of the Tetrahymena ribozyme contributes to 5'-splice site selection and transition state stabilization. Biochemistry. 35: 1201-11. PMID 8573575 DOI: 10.1021/bi952244f  1
1995 Query CC, Strobel SA, Sharp PA. The branch site adenosine is recognized differently for the two steps of pre-mRNA splicing. Nucleic Acids Symposium Series. 224-5. PMID 8643377  1
1995 Strobel SA, Cech TR. Minor groove recognition of the conserved G.U pair at the Tetrahymena ribozyme reaction site. Science (New York, N.Y.). 267: 675-9. PMID 7839142  1
1994 Pyle AM, Moran S, Strobel SA, Chapman T, Turner DH, Cech TR. Replacement of the conserved G.U with a G-C pair at the cleavage site of the Tetrahymena ribozyme decreases binding, reactivity, and fidelity. Biochemistry. 33: 13856-63. PMID 7947794 DOI: 10.1021/bi00250a040  1
1994 Strobel SA, Cech TR. Translocation of an RNA duplex on a ribozyme. Nature Structural Biology. 1: 13-7. PMID 7544680  1
1994 Strobel SA, Cech TR, Usman N, Beigelman L. The 2,6-diaminopurine riboside.5-methylisocytidine wobble base pair: an isoenergetic substitution for the study of G.U pairs in RNA. Biochemistry. 33: 13824-35. PMID 7524665  1
1994 Strobel SA, Cech TR, Usman N, Beigelman L. The 2,6-diaminopurine riboside·5-methylisocytidine wobble base pair: An isoenergetic substitution for the study of G·U pairs in RNA Biochemistry. 33: 13824-13835. DOI: 10.1021/bi00250a037  1
1993 MacDonald ME, Ambrose CM, Duyao MP, Myers RH, Lin C, Srinidhi L, Barnes G, Taylor SA, James M, Groot N, MacFarlane H, Jenkins B, Anderson MA, Wexler NS, Gusella JF, ... ... Strobel SA, et al. A novel gene containing a trinucleotide repeat that is expanded and unstable on Huntington's disease chromosomes Cell. 72: 971-983. PMID 8458085 DOI: 10.1016/0092-8674(93)90585-E  1
1993 Strobel SA, Cech TR. Tertiary interactions with the internal guide sequence mediate docking of the P1 helix into the catalytic core of the Tetrahymena ribozyme. Biochemistry. 32: 13593-604. PMID 7504953 DOI: 10.1021/bi00212a027  1
1992 Strobel SA, Dervan PB. Triple helix-mediated single-site enzymatic cleavage of megabase genomic DNA. Methods in Enzymology. 216: 309-21. PMID 1336095 DOI: 10.1016/0076-6879(92)16029-J  1
1992 Povsic TJ, Strobel SA, Dervan PB. Sequence-specific double-strand alkylation and cleavage of DNA mediated by triple-helix formation Journal of the American Chemical Society. 114: 5934-5941. DOI: 10.1021/ja00041a005  1
1992 Povsic TJ, Strobel SA, Dervan PB. Sequence-specific double-strand alkylation and cleavage of dna mediated by triple-helix formation Journal of the American Chemical Society. 114: 5934-5941.  1
1991 Strobel SA, Dervan PB. Single-site enzymatic cleavage of yeast genomic DNA mediated by triple helix formation. Nature. 350: 172-4. PMID 1848684 DOI: 10.1038/350172a0  1
1991 Strobel SA, Doucette-Stamm LA, Riba L, Housman DE, Dervan PB. Site-specific cleavage of human chromosome 4 mediated by triple-helix formation. Science (New York, N.Y.). 254: 1639-42. PMID 1836279 DOI: 10.1126/science.1836279  1
1990 Strobel SA, Dervan PB. Site-specific cleavage of a yeast chromosome by oligonucleotide-directed triple-helix formation. Science (New York, N.Y.). 249: 73-5. PMID 2195655 DOI: 10.1126/science.2195655  1
1990 Wiemer DF, K. Wolfe L, Fenical W, Strobel SA, Clardy J. Palmosalides A-C, new sesquiterpenoids from the indian ocean telestacean octocoral Coelogorgia palmosa Tetrahedron Letters. 31: 1973-1976. DOI: 10.1016/S0040-4039(00)88892-9  1
1990 Roussis V, Wu Z, Fenical W, Strobel SA, Van Duyne GD, Clardy J. New antiinflammatory pseudopterosins from the marine octocoral Pseudopterogorgia elisabethae Journal of Organic Chemistry. 55: 4916-4922.  1
1989 Strobel SA, Dervan PB. Cooperative site specific binding of oligonucleotides to duplex DNA Journal of the American Chemical Society. 111: 7286-7287. DOI: 10.1021/ja00200a073  1
1989 Strobel SA, Dervan PB. Cooperative site specific binding of oligonucleotides to duplex DNA Journal of the American Chemical Society. 111: 7286-7287.  1
1988 Strobel SA, Moser HE, Dervan PB. Double strand cleavage of genomic DNA at a single site by triple helix formation Journal of the American Chemical Society. 110: 7927-7929. DOI: 10.1021/ja00231a082  1
1988 Sugawara F, Takahashi N, Strobel GA, Strobel SA, Lu HSM, Clardy J. Triticones A and B, novel phytotoxins from the plant pathogenic fungus Drechslera tritici-repentis Journal of the American Chemical Society. 110: 4086-4087.  1
1988 Strobel SA, Moser HE, Dervan PB. Double-strand cleavage of genomic DNA at a single site by triple-helix formation Journal of the American Chemical Society. 110: 7927-7929.  1
1987 Cardellina JH, Hendrickson RL, Manfredi KP, Strobel SA, Clardy J. Bissetone, a unique antimicrobial pyranone from the gorgonian Briareu polyanthes Tetrahedron Letters. 28: 727-730. DOI: 10.1016/S0040-4039(01)80973-4  1
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