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H. Lee Sweeney - Publications

Affiliations: 
1984 Physiology and Biophysics Harvard Medical School, Boston, MA, United States 
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Year Citation  Score
2024 Radnai L, Young EJ, Kikuti C, Hafenbreidel M, Stremel RF, Lin L, Toth K, Pasetto P, Jin X, Patel A, Conlon M, Briggs S, Heidsieck L, Sweeney HL, Sellers J, et al. Development of Clinically Viable Non-Muscle Myosin II Small Molecule Inhibitors with Broad Therapeutic Potential. Biorxiv : the Preprint Server For Biology. PMID 39416074 DOI: 10.1101/2024.10.07.617018  0.587
2023 Canon L, Kikuti C, Planelles-Herrero VJ, Lin T, Mayeux F, Sirkia H, Lee YI, Heidsieck L, Velikovsky L, David A, Liu X, Moussaoui D, Forest E, Höök P, Petersen KJ, ... ... Sweeney HL, et al. How myosin VI traps its off-state, is activated and dimerizes. Nature Communications. 14: 6732. PMID 37872146 DOI: 10.1038/s41467-023-42376-2  0.601
2023 Bodine SC, Sinha I, Sweeney HL. Mechanisms of Skeletal Muscle Atrophy and Molecular Circuitry of Stem Cell Fate in Skeletal Muscle Regeneration and Aging. The Journals of Gerontology. Series a, Biological Sciences and Medical Sciences. 78: 14-18. PMID 37325966 DOI: 10.1093/gerona/glad023  0.312
2023 Russell AJ, DuVall M, Barthel B, Qian Y, Peter AK, Newell-Stamper BL, Hunt K, Lehman SJ, Madden MR, Schlachter ST, Robertson BD, Van Deusen A, Rodriguez HM, Vera CD, Su Y, ... ... Sweeney HL, et al. Modulating fast skeletal muscle contraction protects skeletal muscle in animal models of Duchenne muscular dystrophy. The Journal of Clinical Investigation. PMID 36995778 DOI: 10.1172/JCI153837  0.644
2021 Pospich S, Sweeney HL, Houdusse A, Raunser S. High-resolution structures of the actomyosin-V complex in three nucleotide states provide insights into the force generation mechanism. Elife. 10. PMID 34812732 DOI: 10.7554/eLife.73724  0.619
2021 Hammers DW, Hart CC, Matheny MK, Heimsath EG, Lee YI, Hammer JA, Cheney RE, Sweeney HL. Filopodia powered by class X myosin promote fusion of mammalian myoblasts. Elife. 10. PMID 34519272 DOI: 10.7554/eLife.72419  0.354
2020 Hammers DW, Hart CC, Matheny MK, Wright LA, Armellini M, Barton ER, Sweeney HL. The D2.mdx mouse as a preclinical model of the skeletal muscle pathology associated with Duchenne muscular dystrophy. Scientific Reports. 10: 14070. PMID 32826942 DOI: 10.1038/S41598-020-70987-Y  0.608
2020 Sweeney HL, Houdusse A, Robert-Paganin J. Myosin Structures. Advances in Experimental Medicine and Biology. 1239: 7-19. PMID 32451853 DOI: 10.1007/978-3-030-38062-5_2  0.633
2019 Hammers DW, Hart CC, Patsalos A, Matheny MK, Wright LA, Nagy L, Sweeney HL. Glucocorticoids counteract hypertrophic effects of myostatin inhibition in dystrophic muscle. Jci Insight. PMID 31830002 DOI: 10.1172/Jci.Insight.133276  0.31
2019 Robert-Paganin J, Pylypenko O, Kikuti C, Sweeney HL, Houdusse A. Force Generation by Myosin Motors: A Structural Perspective. Chemical Reviews. PMID 31689091 DOI: 10.1021/Acs.Chemrev.9B00264  0.599
2019 Barton ER, Pham J, Brisson BK, Park S, Smith LR, Liu M, Tian Z, Hammers DW, Vassilakos G, Sweeney HL. Functional muscle hypertrophy by increased insulin-like growth factor 1 does not require dysferlin. Muscle & Nerve. PMID 31323135 DOI: 10.1002/Mus.26641  0.595
2019 Yang Y, Vassilakos G, Hammers DW, Yang Z, Barton ER, Sweeney HL. Smooth muscle atrophy and colon pathology in SMN deficient mice. American Journal of Translational Research. 11: 1789-1799. PMID 30972202  0.6
2018 Blanc F, Isabet T, Benisty H, Sweeney HL, Cecchini M, Houdusse A. An intermediate along the recovery stroke of myosin VI revealed by X-ray crystallography and molecular dynamics. Proceedings of the National Academy of Sciences of the United States of America. PMID 29844196 DOI: 10.1073/Pnas.1711512115  0.584
2018 Sweeney HL, Hammers DW. Muscle Contraction. Cold Spring Harbor Perspectives in Biology. 10. PMID 29419405 DOI: 10.1101/cshperspect.a023200  0.35
2017 Hammers DW, Merscham-Banda M, Hsiao JY, Engst S, Hartman JJ, Sweeney HL. Supraphysiological levels of GDF11 induce striated muscle atrophy. Embo Molecular Medicine. PMID 28270449 DOI: 10.15252/emmm.201607231  0.308
2016 Liu M, Hammers DW, Barton ER, Sweeney HL. Activin Receptor Type IIB Inhibition Improves Muscle Phenotype and Function in a Mouse Model of Spinal Muscular Atrophy. Plos One. 11: e0166803. PMID 27870893 DOI: 10.1371/Journal.Pone.0166803  0.635
2016 Houdusse A, Sweeney HL. How Myosin Generates Force on Actin Filaments. Trends in Biochemical Sciences. PMID 27717739 DOI: 10.1016/J.Tibs.2016.09.006  0.602
2016 Ropars V, Yang Z, Isabet T, Blanc F, Zhou K, Lin T, Liu X, Hissier P, Samazan F, Amigues B, Yang ED, Park H, Pylypenko O, Cecchini M, Sindelar CV, ... Sweeney HL, et al. The myosin X motor is optimized for movement on actin bundles. Nature Communications. 7: 12456. PMID 27580874 DOI: 10.1038/Ncomms12456  0.608
2016 Capote J, Kramerova I, Martinez L, Vetrone S, Barton ER, Sweeney HL, Miceli MC, Spencer MJ. Osteopontin ablation ameliorates muscular dystrophy by shifting macrophages to a pro-regenerative phenotype. The Journal of Cell Biology. 213: 275-88. PMID 27091452 DOI: 10.1083/Jcb.201510086  0.624
2016 Wulf SF, Ropars V, Fujita-Becker S, Oster M, Hofhaus G, Trabuco LG, Pylypenko O, Sweeney HL, Houdusse AM, Schröder RR. Force-producing ADP state of myosin bound to actin. Proceedings of the National Academy of Sciences of the United States of America. PMID 26976594 DOI: 10.1073/Pnas.1516598113  0.613
2016 Abrams J, Einhorn Z, Seiler C, Zong AB, Sweeney HL, Pack M. Graded effects of unregulated smooth muscle myosin on intestinal architecture, intestinal motility, and vascular function in zebrafish. Disease Models & Mechanisms. PMID 26893369 DOI: 10.1242/dmm.023309  0.306
2016 Schroeder RR, Wulf SF, Ropars V, Fujita-Becker S, Oster M, Hofhaus G, Trabuco LG, Pylypenko O, Sweeney HL, Houdusse A. The Force Producing ADP State of Myosin Bound to Actin Biophysical Journal. 110: 13a. DOI: 10.1016/j.bpj.2015.11.129  0.578
2015 Smith LR, Hammers DW, Sweeney HL, Barton ER. Increased collagen cross-linking is a signature of dystrophin-deficient muscle. Muscle & Nerve. PMID 26616495 DOI: 10.1002/Mus.24998  0.596
2015 Llinas P, Isabet T, Song L, Ropars V, Zong B, Benisty H, Sirigu S, Morris C, Kikuti C, Safer D, Sweeney HL, Houdusse A. How actin initiates the motor activity of Myosin. Developmental Cell. 33: 401-12. PMID 25936506 DOI: 10.1016/J.Bpj.2014.11.160  0.635
2015 Pylypenko O, Song L, Shima A, Yang Z, Houdusse AM, Sweeney HL. Myosin VI deafness mutation prevents the initiation of processive runs on actin. Proceedings of the National Academy of Sciences of the United States of America. 112: E1201-9. PMID 25751888 DOI: 10.1073/Pnas.1420989112  0.608
2014 Mukherjea M, Ali MY, Kikuti C, Safer D, Yang Z, Sirkia H, Ropars V, Houdusse A, Warshaw DM, Sweeney HL. Myosin VI must dimerize and deploy its unusual lever arm in order to perform its cellular roles. Cell Reports. 8: 1522-32. PMID 25159143 DOI: 10.1016/J.Celrep.2014.07.041  0.613
2014 Tsai MH, Chang AN, Huang J, He W, Sweeney HL, Zhu M, Kamm KE, Stull JT. Constitutive phosphorylation of myosin phosphatase targeting subunit-1 in smooth muscle. The Journal of Physiology. 592: 3031-51. PMID 24835173 DOI: 10.1113/Jphysiol.2014.273011  0.31
2014 Forbes SC, Bish LT, Ye F, Spinazzola J, Baligand C, Plant D, Vandenborne K, Barton ER, Sweeney HL, Walter GA. Gene transfer of arginine kinase to skeletal muscle using adeno-associated virus. Gene Therapy. 21: 387-92. PMID 24572791 DOI: 10.1038/Gt.2014.9  0.564
2013 Selsby JT, Acosta P, Sleeper MM, Barton ER, Sweeney HL. Long-term wheel running compromises diaphragm function but improves cardiac and plantarflexor function in the mdx mouse. Journal of Applied Physiology (Bethesda, Md. : 1985). 115: 660-6. PMID 23823150 DOI: 10.1152/Japplphysiol.00252.2013  0.604
2013 Ye F, Mathur S, Liu M, Borst SE, Walter GA, Sweeney HL, Vandenborne K. Overexpression of insulin-like growth factor-1 attenuates skeletal muscle damage and accelerates muscle regeneration and functional recovery after disuse. Experimental Physiology. 98: 1038-52. PMID 23291913 DOI: 10.1113/Expphysiol.2012.070722  0.311
2013 Ali MY, Previs SB, Trybus KM, Sweeney HL, Warshaw DM. Myosin VI has a one track mind versus myosin Va when moving on actin bundles or at an intersection. Traffic (Copenhagen, Denmark). 14: 70-81. PMID 23046080 DOI: 10.1111/tra.12017  0.307
2012 Ménétrey J, Isabet T, Ropars V, Mukherjea M, Pylypenko O, Liu X, Perez J, Vachette P, Sweeney HL, Houdusse AM. Processive steps in the reverse direction require uncoupling of the lead head lever arm of myosin VI. Molecular Cell. 48: 75-86. PMID 22940248 DOI: 10.1016/J.Molcel.2012.07.034  0.625
2012 Selsby JT, Morine KJ, Pendrak K, Barton ER, Sweeney HL. Rescue of dystrophic skeletal muscle by PGC-1α involves a fast to slow fiber type shift in the mdx mouse. Plos One. 7: e30063. PMID 22253880 DOI: 10.1371/Journal.Pone.0030063  0.605
2012 Llinas P, Pylypenko O, Isabet T, Mukherjea M, Sweeney HL, Houdusse AM. How myosin motors power cellular functions: an exciting journey from structure to function: based on a lecture delivered at the 34th FEBS Congress in Prague, Czech Republic, July 2009. The Febs Journal. 279: 551-62. PMID 22171985 DOI: 10.1111/J.1742-4658.2011.08449.X  0.621
2012 Qaisar R, Renaud G, Morine K, Barton ER, Sweeney HL, Larsson L. Is functional hypertrophy and specific force coupled with the addition of myonuclei at the single muscle fiber level? Faseb Journal : Official Publication of the Federation of American Societies For Experimental Biology. 26: 1077-85. PMID 22125316 DOI: 10.1096/Fj.11-192195  0.654
2011 Bish LT, Yarchoan M, Sleeper MM, Gazzara JA, Morine KJ, Acosta P, Barton ER, Sweeney HL. Chronic losartan administration reduces mortality and preserves cardiac but not skeletal muscle function in dystrophic mice. Plos One. 6: e20856. PMID 21731628 DOI: 10.1371/Journal.Pone.0020856  0.615
2011 Pylypenko O, Song L, Squires G, Liu X, Zong AB, Houdusse A, Sweeney HL. Role of insert-1 of myosin VI in modulating nucleotide affinity. The Journal of Biological Chemistry. 286: 11716-23. PMID 21278381 DOI: 10.1074/Jbc.M110.200626  0.578
2011 Shima A, Pham J, Blanco E, Barton ER, Sweeney HL, Matsuda R. IGF-I and vitamin C promote myogenic differentiation of mouse and human skeletal muscle cells at low temperatures. Experimental Cell Research. 317: 356-66. PMID 21070767 DOI: 10.1016/J.Yexcr.2010.11.001  0.573
2011 Sen S, Tewari M, Zajac A, Barton E, Sweeney HL, Discher DE. Upregulation of paxillin and focal adhesion signaling follows Dystroglycan Complex deletions and promotes a hypertensive state of differentiation. European Journal of Cell Biology. 90: 249-60. PMID 20663583 DOI: 10.1016/J.Ejcb.2010.06.005  0.592
2010 Selsby J, Pendrak K, Zadel M, Tian Z, Pham J, Carver T, Acosta P, Barton E, Sweeney HL. Leupeptin-based inhibitors do not improve the mdx phenotype. American Journal of Physiology. Regulatory, Integrative and Comparative Physiology. 299: R1192-201. PMID 20844259 DOI: 10.1152/Ajpregu.00586.2009  0.611
2010 Stevens-Lapsley JE, Ye F, Liu M, Borst SE, Conover C, Yarasheski KE, Walter GA, Sweeney HL, Vandenborne K. Impact of viral-mediated IGF-I gene transfer on skeletal muscle following cast immobilization. American Journal of Physiology. Endocrinology and Metabolism. 299: E730-40. PMID 20739512 DOI: 10.1152/Ajpendo.00230.2010  0.331
2010 Morine KJ, Bish LT, Selsby JT, Gazzara JA, Pendrak K, Sleeper MM, Barton ER, Lee SJ, Sweeney HL. Activin IIB receptor blockade attenuates dystrophic pathology in a mouse model of Duchenne muscular dystrophy. Muscle & Nerve. 42: 722-30. PMID 20730876 DOI: 10.1002/Mus.21743  0.6
2010 Wang B, Yang Z, Brisson BK, Feng H, Zhang Z, Welch EM, Peltz SW, Barton ER, Brown RH, Sweeney HL. Membrane blebbing as an assessment of functional rescue of dysferlin-deficient human myotubes via nonsense suppression. Journal of Applied Physiology (Bethesda, Md. : 1985). 109: 901-5. PMID 20558759 DOI: 10.1152/Japplphysiol.01366.2009  0.579
2010 Barton ER, Wang BJ, Brisson BK, Sweeney HL. Diaphragm displays early and progressive functional deficits in dysferlin-deficient mice. Muscle & Nerve. 42: 22-9. PMID 20544921 DOI: 10.1002/Mus.21645  0.638
2010 Morine KJ, Sleeper MM, Barton ER, Sweeney HL. Overexpression of SERCA1a in the mdx diaphragm reduces susceptibility to contraction-induced damage. Human Gene Therapy. 21: 1735-9. PMID 20540606 DOI: 10.1089/Hum.2010.077  0.604
2010 Sweeney HL, Houdusse A. Myosin VI Rewrites the Rules for Myosin Motors Cell. 141: 573-582. PMID 20478251 DOI: 10.1016/J.Cell.2010.04.028  0.631
2010 Sweeney HL, Houdusse A. Structural and functional insights into the myosin motor mechanism Annual Review of Biophysics. 39: 539-557. PMID 20192767 DOI: 10.1146/Annurev.Biophys.050708.133751  0.658
2010 Morine KJ, Bish LT, Pendrak K, Sleeper MM, Barton ER, Sweeney HL. Systemic myostatin inhibition via liver-targeted gene transfer in normal and dystrophic mice. Plos One. 5: e9176. PMID 20161803 DOI: 10.1371/Journal.Pone.0009176  0.572
2010 Shima A, Barton E, Sweeney H, Matsuda R. P3.20 Mouse and human skeletal muscle cells differentiate in a temperature-dependent manner Neuromuscular Disorders. 20: 647. DOI: 10.1016/J.Nmd.2010.07.162  0.589
2010 Kim H, Hsin J, Liu Y, Mukherjea M, Safer D, Houdusse A, Sweeney HL, Schulten K, Selvin PR. Single-Molecule and Molecular Dynamics Study of the Dimerization of Myosin VI Medial Tail Domain Biophysical Journal. 98: 724a. DOI: 10.1016/J.Bpj.2009.12.3969  0.568
2010 Mukherjea M, Llinas P, Safer D, Houdusse A, Sweeney HL. Dimerization is Essential for the Large Step Size of Myosin VI Biophysical Journal. 98: 724a. DOI: 10.1016/J.Bpj.2009.12.3967  0.633
2010 Liu Y, Hsin J, Kim H, Houdusse A, Sweeney HL, Selvin PR, Schulten K. Steered Molecular Dynamics Simulation of Unfolding of Myosin VI Proximal Tail Domain Biophysical Journal. 98: 724a. DOI: 10.1016/J.Bpj.2009.12.3966  0.582
2009 Mukherjea M, Llinas P, Kim H, Travaglia M, Safer D, Ménétrey J, Franzini-Armstrong C, Selvin PR, Houdusse A, Sweeney HL. Myosin VI dimerization triggers an unfolding of a three-helix bundle in order to extend its reach. Molecular Cell. 35: 305-15. PMID 19664948 DOI: 10.1016/J.Molcel.2009.07.010  0.631
2009 Qaiasr R, Morine K, Barton E, Sweeney H, Larsson L. EM.P.1.07 Effects of muscle hypertrophy on individual myonuclear domain sizes in single muscle fibers from myostatin deficient or IGF-1 over-expressing mice Neuromuscular Disorders. 19: 551. DOI: 10.1016/J.Nmd.2009.06.028  0.624
2009 Mukherjea M, Safer D, Ménétrey J, Llinas P, Houdusse A, Sweeney HL. Myosin VI Dimerizes And Walks Processively Along Actin Biophysical Journal. 96: 142a. DOI: 10.1016/J.Bpj.2008.12.3884  0.627
2009 Phichith D, Travaglia M, Yang Z, Zong AB, Safer D, Franzini-Armstrong C, Sweeney HL. Cargo-mediated dimerization of Myosin VI Biophysical Journal. 96: 141a. DOI: 10.1016/J.Bpj.2008.12.3877  0.348
2008 Millay DP, Sargent MA, Osinska H, Baines CP, Barton ER, Vuagniaux G, Sweeney HL, Robbins J, Molkentin JD. Genetic and pharmacologic inhibition of mitochondrial-dependent necrosis attenuates muscular dystrophy. Nature Medicine. 14: 442-7. PMID 18345011 DOI: 10.1038/Nm1736  0.594
2008 Ménétrey J, Llinas P, Cicolari J, Squires G, Liu X, Li A, Sweeney HL, Houdusse A. The post-rigor structure of myosin VI and implications for the recovery stroke. The Embo Journal. 27: 244-52. PMID 18046460 DOI: 10.1038/Sj.Emboj.7601937  0.622
2008 Houdusse A, Llinas P, Menetrey J, Cicolari J, Sweeney H. Structural description of the ATPase cycle of a myosin that moves backward Acta Crystallographica Section a Foundations of Crystallography. 64: C78-C79. DOI: 10.1107/S0108767308097481  0.559
2007 Ménétrey J, Llinas P, Mukherjea M, Sweeney HL, Houdusse A. The structural basis for the large powerstroke of myosin VI. Cell. 131: 300-8. PMID 17956731 DOI: 10.1016/J.Cell.2007.08.027  0.628
2007 Sweeney HL, Park H, Zong AB, Yang Z, Selvin PR, Rosenfeld SS. How myosin VI coordinates its heads during processive movement. The Embo Journal. 26: 2682-92. PMID 17510632 DOI: 10.1038/Sj.Emboj.7601720  0.318
2007 Welch EM, Barton ER, Zhuo J, Tomizawa Y, Friesen WJ, Trifillis P, Paushkin S, Patel M, Trotta CR, Hwang S, Wilde RG, Karp G, Takasugi J, Chen G, Jones S, ... ... Sweeney HL, et al. PTC124 targets genetic disorders caused by nonsense mutations. Nature. 447: 87-91. PMID 17450125 DOI: 10.1038/Nature05756  0.573
2007 Parsons SA, Millay DP, Sargent MA, Naya FJ, McNally EM, Sweeney HL, Molkentin JD. Genetic disruption of calcineurin improves skeletal muscle pathology and cardiac disease in a mouse model of limb-girdle muscular dystrophy. The Journal of Biological Chemistry. 282: 10068-78. PMID 17289669 DOI: 10.1074/Jbc.M609368200  0.339
2007 Park H, Li A, Chen LQ, Houdusse A, Selvin PR, Sweeney HL. The unique insert at the end of the myosin VI motor is the sole determinant of directionality. Proceedings of the National Academy of Sciences of the United States of America. 104: 778-83. PMID 17213313 DOI: 10.1073/Pnas.0610066104  0.614
2007 Sweeney HL, Houdusse A. What can myosin VI do in cells? Current Opinion in Cell Biology. 19: 57-66. PMID 17175153 DOI: 10.1016/J.Ceb.2006.12.005  0.617
2005 Chevreux G, Potier N, Van Dorsselaer A, Bahloul A, Houdusse A, Wells A, Sweeney HL. Electrospray ionization mass spectrometry studies of noncovalent myosin VI complexes reveal a new specific calmodulin binding site. Journal of the American Society For Mass Spectrometry. 16: 1367-76. PMID 15979337 DOI: 10.1016/J.Jasms.2005.03.023  0.575
2005 Morris CA, Morris LD, Kennedy AR, Sweeney HL. Attenuation of skeletal muscle atrophy via protease inhibition. Journal of Applied Physiology (Bethesda, Md. : 1985). 99: 1719-27. PMID 15976355 DOI: 10.1152/japplphysiol.01419.2004  0.314
2005 Ménétrey J, Bahloul A, Wells AL, Yengo CM, Morris CA, Sweeney HL, Houdusse A. The structure of the myosin VI motor reveals the mechanism of directionality reversal. Nature. 435: 779-85. PMID 15944696 DOI: 10.1038/Nature03592  0.633
2005 Rosenfeld SS, Houdusse A, Sweeney HL. Magnesium regulates ADP dissociation from myosin V Journal of Biological Chemistry. 280: 6072-6079. PMID 15579901 DOI: 10.1074/Jbc.M412717200  0.578
2004 Sweeney HL, Houdusse A. The motor mechanism of myosin V: insights for muscle contraction. Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences. 359: 1829-41. PMID 15647159 DOI: 10.1098/Rstb.2004.1576  0.662
2004 Holmes KC, Schröder RR, Sweeney HL, Houdusse A. The structure of the rigor complex and its implications for the power stroke. Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences. 359: 1819-28. PMID 15647158 DOI: 10.1098/Rstb.2004.1566  0.596
2004 Coureux PD, Sweeney HL, Houdusse A. Three myosin V structures delineate essential features of chemo-mechanical transduction Embo Journal. 23: 4527-4537. PMID 15510214 DOI: 10.1038/Sj.Emboj.7600458  0.618
2004 Bahloul A, Chevreux G, Wells AL, Martin D, Nolt J, Yang Z, Chen LQ, Potier N, Van Dorsselaer A, Rosenfeld S, Houdusse A, Sweeney HL. The unique insert in myosin VI is a structural calcium-calmodulin binding site. Proceedings of the National Academy of Sciences of the United States of America. 101: 4787-92. PMID 15037754 DOI: 10.1073/Pnas.0306892101  0.577
2004 Lee S, Barton ER, Sweeney HL, Farrar RP. Viral expression of insulin-like growth factor-I enhances muscle hypertrophy in resistance-trained rats. Journal of Applied Physiology (Bethesda, Md. : 1985). 96: 1097-104. PMID 14766764 DOI: 10.1152/Japplphysiol.00479.2003  0.582
2003 Kobinger GP, Louboutin JP, Barton ER, Sweeney HL, Wilson JM. Correction of the dystrophic phenotype by in vivo targeting of muscle progenitor cells. Human Gene Therapy. 14: 1441-9. PMID 14577924 DOI: 10.1089/104303403769211655  0.604
2003 Coureux PD, Wells AL, Ménétrey J, Yengo CM, Morris CA, Sweeney HL, Houdusse A. A structural state of the myosin V motor without bound nucleotide. Nature. 425: 419-23. PMID 14508494 DOI: 10.1038/Nature01927  0.636
2003 Joel PB, Sweeney HL, Trybus KM. Addition of lysines to the 50/20 kDa junction of myosin strengthens weak binding to actin without affecting the maximum ATPase activity Biochemistry. 42: 9160-9166. PMID 12885250 DOI: 10.1021/bi034415j  0.322
2003 Chatterjee S, Bish LT, Jayasankar V, Stewart AS, Woo YJ, Crow MT, Gardner TJ, Sweeney HL. Blocking the development of postischemic cardiomyopathy with viral gene transfer of the apoptosis repressor with caspase recruitment domain. The Journal of Thoracic and Cardiovascular Surgery. 125: 1461-9. PMID 12830068 DOI: 10.1016/S0022-5223(02)73229-7  0.525
2003 Xiao M, Reifenberger JG, Wells AL, Baldacchino C, Chen LQ, Ge P, Sweeney HL, Selvin PR. An actin-dependent conformational change in myosin. Nature Structural Biology. 10: 402-8. PMID 12679807 DOI: 10.1038/Nsb916  0.319
2002 Barton ER, Morris L, Musaro A, Rosenthal N, Sweeney HL. Muscle-specific expression of insulin-like growth factor I counters muscle decline in mdx mice. The Journal of Cell Biology. 157: 137-48. PMID 11927606 DOI: 10.1083/Jcb.200108071  0.636
2002 Chatterjee S, Jayasankar V, Bish LT, Stewart AS, Woo Y, Crow MT, Gardner TJ, Sweeney H. 05 Viral gene transfer of ARC and BCL-2 confers similar protection against cardiomyopathy after myocardial ischemia Journal of Molecular and Cellular Cardiology. 34: A32. DOI: 10.1016/S0022-2828(02)90181-1  0.513
2001 Rock RS, Rice SE, Wells AL, Purcell TJ, Spudich JA, Sweeney HL. Myosin VI is a processive motor with a large step size. Proceedings of the National Academy of Sciences of the United States of America. 98: 13655-9. PMID 11707568 DOI: 10.1073/Pnas.191512398  0.33
2001 De La Cruz EM, Ostap EM, Sweeney HL. Kinetic mechanism and regulation of myosin VI. The Journal of Biological Chemistry. 276: 32373-81. PMID 11423557 DOI: 10.1074/Jbc.M104136200  0.3
2001 Houdusse A, Sweeney HL. Myosin motors: Missing structures and hidden springs Current Opinion in Structural Biology. 11: 182-194. PMID 11297926 DOI: 10.1016/S0959-440X(00)00188-3  0.645
2001 Musarò A, McCullagh K, Paul A, Houghton L, Dobrowolny G, Molinaro M, Barton ER, Sweeney HL, Rosenthal N. Localized Igf-1 transgene expression sustains hypertrophy and regeneration in senescent skeletal muscle. Nature Genetics. 27: 195-200. PMID 11175789 DOI: 10.1038/84839  0.63
2000 Sweeney HL, Barton ER. The dystrophin-associated glycoprotein complex: What parts can you do without? Proceedings of the National Academy of Sciences of the United States of America. 97: 13464-13466. PMID 11095702 DOI: 10.1073/Pnas.011510597  0.613
2000 Sweeney HL, Chen LQ, Trybus KM. Regulation of asymmetric smooth muscle myosin II molecules Journal of Biological Chemistry. 275: 41273-41277. PMID 11018047 DOI: 10.1074/jbc.M008310200  0.304
2000 Cordier L, Hack AA, Scott MO, Barton-Davis ER, Gao G, Wilson JM, McNally EM, Sweeney HL. Rescue of skeletal muscles of gamma-sarcoglycan-deficient mice with adeno-associated virus-mediated gene transfer. Molecular Therapy : the Journal of the American Society of Gene Therapy. 1: 119-29. PMID 10933922 DOI: 10.1006/Mthe.1999.0019  0.315
2000 Rosenfeld SS, Xing J, Whitaker M, Cheung HC, Brown F, Wells A, Milligan RA, Sweeney HL. Kinetic and spectroscopic evidence for three actomyosin:ADP states in smooth muscle. The Journal of Biological Chemistry. 275: 25418-26. PMID 10827085 DOI: 10.1074/Jbc.M002685200  0.376
2000 Walter G, Barton ER, Sweeney HL. Noninvasive measurement of gene expression in skeletal muscle Proceedings of the National Academy of Sciences of the United States of America. 97: 5151-5155. PMID 10805778 DOI: 10.1073/Pnas.97.10.5151  0.556
1999 De La Cruz EM, Wells AL, Rosenfeld SS, Ostap EM, Sweeney HL. The kinetic mechanism of myosin V. Proceedings of the National Academy of Sciences of the United States of America. 96: 13726-31. PMID 10570140 DOI: 10.1073/Pnas.96.24.13726  0.306
1999 Wells AL, Lin AW, Chen LQ, Safer D, Cain SM, Hasson T, Carragher BO, Milligan RA, Sweeney HL. Myosin VI is an actin-based motor that moves backwards. Nature. 401: 505-8. PMID 10519557 DOI: 10.1038/46835  0.327
1999 Hack AA, Cordier L, Shoturma DI, Lam MY, Sweeney HL, McNally EM. Muscle degeneration without mechanical injury in sarcoglycan deficiency. Proceedings of the National Academy of Sciences of the United States of America. 96: 10723-8. PMID 10485893 DOI: 10.1073/Pnas.96.19.10723  0.318
1999 Dantzig JA, Barsotti RJ, Manz S, Sweeney HL, Goldman YE. The ADP release step of the smooth muscle cross-bridge cycle is not directly associated with force generation. Biophysical Journal. 77: 386-97. PMID 10388765 DOI: 10.1016/S0006-3495(99)76897-9  0.368
1999 Barton-Davis ER, Shoturma DI, Musaro A, Rosenthal N, Sweeney HL. Viral mediated expression of insulin-like growth factor I blocks the aging-related loss of skeletal muscle function. Proceedings of the National Academy of Sciences of the United States of America. 95: 15603-7. PMID 9861016 DOI: 10.1073/Pnas.95.26.15603  0.325
1998 Sweeney HL. Regulation and tuning of smooth muscle myosin American Journal of Respiratory and Critical Care Medicine. 158. PMID 9817731  0.384
1998 Trybus KM, Naroditskaya V, Sweeney HL. The light chain-binding domain of the smooth muscle myosin heavy chain is not the only determinant of regulation Journal of Biological Chemistry. 273: 18423-18428. PMID 9660810 DOI: 10.1074/jbc.273.29.18423  0.376
1997 Trybus KM, Freyzon Y, Faust LZ, Sweeney HL. Spare the rod, spoil the regulation: necessity for a myosin rod. Proceedings of the National Academy of Sciences of the United States of America. 94: 48-52. PMID 8990159 DOI: 10.1073/pnas.94.1.48  0.334
1995 Levine RJC, Kensler RW, Yang Z, Sweeney HL. Myosin regulatory light chain phosphorylation and the production of functionally significant changes in myosin head arrangement on striated muscle thick filaments Biophysical Journal. 68. PMID 7787078  0.314
1995 Sweeney HL, Reggiani C, Lowey S, Rayment I, Schutt C, Chase PB, Cremo C. Function of the N terminus of the myosin essential light chain of vertebrate striated muscle Biophysical Journal. 68: 112s-119s. PMID 7787052  0.573
1995 Yang Z, Sweeney HL. Restoration of phosphorylation-dependent regulation to the skeletal muscle myosin regulatory light chain Journal of Biological Chemistry. 270: 24646-24649. PMID 7559573 DOI: 10.1074/Jbc.270.42.24646  0.31
1995 Whittaker M, Wilson-Kubalek EM, Smith JE, Faust L, Milligan RA, Sweeney HL. A 35-A movement of smooth muscle myosin on ADP release. Nature. 378: 748-51. PMID 7501026 DOI: 10.1038/378748A0  0.316
1994 Sweeney HL, Yang Z, Zhi G, Stull JT, Trybus KM. Charge replacement near the phosphorylatable serine of the myosin regulatory light chain mimics aspects of phosphorylation. Proceedings of the National Academy of Sciences of the United States of America. 91: 1490-1494. PMID 8108436 DOI: 10.1073/Pnas.91.4.1490  0.351
1993 Petrof BJ, Shrager JB, Stedman HH, Kelly AM, Sweeney HL. Dystrophin protects the sarcolemma from stresses developed during muscle contraction Proceedings of the National Academy of Sciences of the United States of America. 90: 3710-3714. PMID 8475120 DOI: 10.1073/Pnas.90.8.3710  0.322
1993 Sweeney HL, Bowman BF, Stull JT. Myosin light chain phosphorylation in vertebrate striated muscle: Regulation and function American Journal of Physiology - Cell Physiology. 264. PMID 8388631 DOI: 10.1152/Ajpcell.1993.264.5.C1085  0.345
1991 Stedman HH, Sweeney HL, Shrager JB, Maguire HC, Panettieri RA, Petrof B, Narusawa M, Leferovich JM, Sladky JT, Kelly AM. The mdx mouse diaphragm reproduces the degenerative changes of Duchenne muscular dystrophy. Nature. 352: 536-9. PMID 1865908 DOI: 10.1038/352536A0  0.311
1990 Stull JT, Bowman BF, Gallagher PJ, Herring BP, Hsu LC, Kamm KE, Kubota Y, Leachman SA, Sweeney HL, Tansey MG. Myosin phosphorylation in smooth and skeletal muscles: regulation and function. Progress in Clinical and Biological Research. 327: 107-26. PMID 2181457  0.324
1990 Sweeney HL, Stull JT. Alteration of cross-bridge kinetics by myosin light chain phosphorylation in rabbit skeletal muscle: Implications for regulation of actin-myosin interaction Proceedings of the National Academy of Sciences of the United States of America. 87: 414-418. PMID 2136951 DOI: 10.1073/Pnas.87.1.414  0.308
1988 Sweeney HL, Kushmerick MJ, Mabuchi K, Sréter FA, Gergely J. Myosin alkali light chain and heavy chain variations correlate with altered shortening velocity of isolated skeletal muscle fibers. The Journal of Biological Chemistry. 263: 9034-9. PMID 3379059  0.535
1987 Sweeney HL, Corteselli SA, Kushmerick MJ. Measurements on permeabilized skeletal muscle fibers during continuous activation. The American Journal of Physiology. 252: C575-80. PMID 3578507 DOI: 10.1152/ajpcell.1987.252.5.C575  0.572
1986 Kushmerick MJ, Dillon PF, Meyer RA, Brown TR, Krisanda JM, Sweeney HL. 31P NMR spectroscopy, chemical analysis, and free Mg2+ of rabbit bladder and uterine smooth muscle. The Journal of Biological Chemistry. 261: 14420-9. PMID 3771537  0.534
1986 Sweeney HL, Kushmerick MJ, Mabuchi K, Gergely J, Sréter FA. Velocity of shortening and myosin isozymes in two types of rabbit fast-twitch muscle fibers. The American Journal of Physiology. 251: C431-4. PMID 3019147 DOI: 10.1152/Ajpcell.1986.251.3.C431  0.568
1985 Sweeney HL, Kushmerick MJ. Myosin phosphorylation in permeabilized rabbit psoas fibers. The American Journal of Physiology. 249: C362-5. PMID 4037077 DOI: 10.1152/ajpcell.1985.249.3.C362  0.549
1985 Sweeney HL, Kushmerick MJ, Mabuchi K, Gergely J, Sreter F. DIFFERENTIAL MYOSIN ISOZYME DISTRIBUTIONS AND SHORTENING VELOCITIES OF RABBIT SKINED SKELETAL MUSCLE FIBERS Medicine & Science in Sports & Exercise. 17: 244. DOI: 10.1249/00005768-198504000-00279  0.592
1984 Meyer RA, Sweeney HL, Kushmerick MJ. A simple analysis of the "phosphocreatine shuttle". The American Journal of Physiology. 246: C365-77. PMID 6372517 DOI: 10.1152/ajpcell.1984.246.5.C365  0.503
Low-probability matches (unlikely to be authored by this person)
1986 Sweeney HL, Stull JT. Phosphorylation of myosin in permeabilized mammalian cardiac and skeletal muscle cells American Journal of Physiology - Cell Physiology. 250. PMID 3754389 DOI: 10.1152/Ajpcell.1986.250.4.C657  0.296
2004 Yildiz A, Park H, Safer D, Yang Z, Chen LQ, Selvin PR, Sweeney HL. Myosin VI steps via a hand-over-hand mechanism with its lever arm undergoing fluctuations when attached to actin. The Journal of Biological Chemistry. 279: 37223-6. PMID 15254036 DOI: 10.1074/Jbc.C400252200  0.295
1990 Walters TJ, Sweeney HL, Farrar RP. Aging does not affect contractile properties of type IIb FDL muscle in Fischer 344 rats American Journal of Physiology - Cell Physiology. 258. PMID 2360618 DOI: 10.1152/Ajpcell.1990.258.6.C1031  0.295
2020 Qin X, Yoo H, Man Cheng HC, Nguyen QQ, Li J, Liu X, Prunetti L, Chen X, Liu T, Sweeney HL, Park H. Simultaneous tracking of two motor domains reveals near simultaneous steps and stutter steps of myosin 10 on actin filament bundles. Biochemical and Biophysical Research Communications. PMID 32081426 DOI: 10.1016/J.Bbrc.2020.02.039  0.294
2009 Phichith D, Travaglia M, Yang Z, Liu X, Zong AB, Safer D, Sweeney HL. Cargo binding induces dimerization of myosin VI. Proceedings of the National Academy of Sciences of the United States of America. 106: 17320-4. PMID 19805065 DOI: 10.1073/Pnas.0909748106  0.293
2010 Chaudhuri T, Rehfeldt F, Sweeney HL, Discher DE. Preparation of collagen-coated gels that maximize in vitro myogenesis of stem cells by matching the lateral elasticity of in vivo muscle. Methods in Molecular Biology (Clifton, N.J.). 621: 185-202. PMID 20405368 DOI: 10.1007/978-1-60761-063-2_13  0.291
2005 Walter G, Cordier L, Bloy D, Sweeney HL. Noninvasive monitoring of gene correction in dystrophic muscle Magnetic Resonance in Medicine. 54: 1369-1376. PMID 16261578 DOI: 10.1002/mrm.20721  0.291
2008 Hertzano R, Shalit E, Rzadzinska AK, Dror AA, Song L, Ron U, Tan JT, Shitrit AS, Fuchs H, Hasson T, Ben-Tal N, Sweeney HL, de Angelis MH, Steel KP, Avraham KB. A Myo6 mutation destroys coordination between the myosin heads, revealing new functions of myosin VI in the stereocilia of mammalian inner ear hair cells. Plos Genetics. 4: e1000207. PMID 18833301 DOI: 10.1371/Journal.Pgen.1000207  0.29
1999 Barton-Davis ER, Cordier L, Shoturma DI, Leland SE, Sweeney HL. Aminoglycoside antibiotics restore dystrophin function to skeletal muscles of mdx mice. The Journal of Clinical Investigation. 104: 375-81. PMID 10449429 DOI: 10.1172/JCI7866  0.29
1990 Sweeney HL, Brito RM, Rosevear PR, Putkey JA. The low-affinity Ca2(+)-binding sites in cardiac/slow skeletal muscle troponin C perform distinct functions: site I alone cannot trigger contraction. Proceedings of the National Academy of Sciences of the United States of America. 87: 9538-42. PMID 2263608 DOI: 10.1073/Pnas.87.24.9538  0.289
1993 Petrof BJ, Stedman HH, Shrager JB, Eby J, Sweeney HL, Kelly AM. Adaptations in myosin heavy chain expression and contractile function in dystrophic mouse diaphragm. The American Journal of Physiology. 265: C834-41. PMID 8214039 DOI: 10.1152/Ajpcell.1993.265.3.C834  0.289
2005 Purcell TJ, Sweeney HL, Spudich JA. A force-dependent state controls the coordination of processive myosin V. Proceedings of the National Academy of Sciences of the United States of America. 102: 13873-8. PMID 16150709 DOI: 10.1073/Pnas.0506441102  0.288
2004 Yengo CM, Sweeney HL. Functional role of loop 2 in myosin V. Biochemistry. 43: 2605-12. PMID 14992598 DOI: 10.1021/Bi035510V  0.287
2003 Chakrabarty T, Yengo C, Baldacchino C, Chen LQ, Sweeney HL, Selvin PR. Does the S2 rod of myosin II uncoil upon two-headed binding to actin? A leucine-zippered HMM study. Biochemistry. 42: 12886-92. PMID 14596602 DOI: 10.1021/Bi035144F  0.287
2018 Sweeney HL. Too much of a good thing. Elife. 7. PMID 30222106 DOI: 10.7554/eLife.41178  0.286
2003 Rosenfeld SS, Xing J, Chen LQ, Sweeney HL. Myosin IIb is unconventionally conventional. The Journal of Biological Chemistry. 278: 27449-55. PMID 12740390 DOI: 10.1074/jbc.M302555200  0.286
2012 Forbes SC, Lott DJ, Finkel RS, Senesac C, Byrne BJ, Sweeney HL, Walter GA, Vandenborne K. MRI/MRS evaluation of a female carrier of Duchenne muscular dystrophy. Neuromuscular Disorders : Nmd. 22: S111-21. PMID 22980762 DOI: 10.1016/J.Nmd.2012.05.013  0.286
1991 Putkey JA, Liu W, Sweeney HL. Function of the N-terminal calcium-binding sites in cardiac/slow troponin C assessed in fast skeletal muscle fibers. The Journal of Biological Chemistry. 266: 14881-4. PMID 1869527  0.285
2013 Arpan I, Forbes SC, Lott DJ, Senesac CR, Daniels MJ, Triplett WT, Deol JK, Sweeney HL, Walter GA, Vandenborne K. Tâ‚‚ mapping provides multiple approaches for the characterization of muscle involvement in neuromuscular diseases: a cross-sectional study of lower leg muscles in 5-15-year-old boys with Duchenne muscular dystrophy. Nmr in Biomedicine. 26: 320-8. PMID 23044995 DOI: 10.1002/Nbm.2851  0.284
2010 Morris CA, Selsby JT, Morris LD, Pendrak K, Sweeney HL. Bowman-Birk inhibitor attenuates dystrophic pathology in mdx mice. Journal of Applied Physiology (Bethesda, Md. : 1985). 109: 1492-9. PMID 20847128 DOI: 10.1152/japplphysiol.01283.2009  0.281
2004 Engler AJ, Griffin MA, Sen S, Bönnemann CG, Sweeney HL, Discher DE. Myotubes differentiate optimally on substrates with tissue-like stiffness: pathological implications for soft or stiff microenvironments. The Journal of Cell Biology. 166: 877-87. PMID 15364962 DOI: 10.1083/Jcb.200405004  0.281
2004 Rosenfeld SS, Sweeney HL. A model of myosin V processivity Journal of Biological Chemistry. 279: 40100-40111. PMID 15254035 DOI: 10.1074/jbc.M402583200  0.28
1997 Levine RJ, Kensler RW, Yang Z, Stull JT, Sweeney HL. Myosin light chain phosphorylation affects the structure of rabbit skeletal muscle thick filaments. Biophysical Journal. 71: 898-907. PMID 8842229 DOI: 10.1016/S0006-3495(96)79293-7  0.278
1998 Rosenfeld SS, Xing J, Cheung HC, Brown F, Kar S, Sweeney HL. Structural and kinetic studies of phosphorylation-dependent regulation in smooth muscle myosin. The Journal of Biological Chemistry. 273: 28682-90. PMID 9786863 DOI: 10.1074/Jbc.273.44.28682  0.278
2006 Park H, Ramamurthy B, Travaglia M, Safer D, Chen LQ, Franzini-Armstrong C, Selvin PR, Sweeney HL. Full-length myosin VI dimerizes and moves processively along actin filaments upon monomer clustering. Molecular Cell. 21: 331-6. PMID 16455488 DOI: 10.1016/J.Molcel.2005.12.015  0.276
2002 Yengo CM, De la Cruz EM, Safer D, Ostap EM, Sweeney HL. Kinetic characterization of the weak binding states of myosin V. Biochemistry. 41: 8508-17. PMID 12081502 DOI: 10.1021/Bi015969U  0.276
2016 Chang AN, Mahajan P, Knapp S, Barton H, Sweeney HL, Kamm KE, Stull JT. Cardiac myosin light chain is phosphorylated by Ca2+/calmodulin-dependent and -independent kinase activities. Proceedings of the National Academy of Sciences of the United States of America. PMID 27325775 DOI: 10.1073/Pnas.1600633113  0.275
1992 Negele JC, Dotson DG, Liu W, Sweeney HL, Putkey JA. Mutation of the high affinity calcium binding sites in cardiac troponin C. The Journal of Biological Chemistry. 267: 825-31. PMID 1530938  0.275
1991 Wilkinson RS, Nemeth PM, Rosser BW, Sweeney HL. Metabolic capacity and myosin expression in single muscle fibres of the garter snake. The Journal of Physiology. 440: 113-29. PMID 1804957  0.275
2005 Wallace KN, Dolan AC, Seiler C, Smith EM, Yusuff S, Chaille-Arnold L, Judson B, Sierk R, Yengo C, Sweeney HL, Pack M. Mutation of smooth muscle myosin causes epithelial invasion and cystic expansion of the zebrafish intestine. Developmental Cell. 8: 717-26. PMID 15866162 DOI: 10.1016/J.Devcel.2005.02.015  0.274
2010 Chaudhuri T, Discher DE, Sweeney HL. A Suitably Compliant Microenvironment Commits Mesenchymal Stem Cells to Differentiate into Muscle Like Cells Which Restore Muscular Defects in Dystrophic Models Biophysical Journal. 98: 611a. DOI: 10.1016/J.Bpj.2009.12.3332  0.273
2018 Willcocks RJ, Triplett WT, Lott DJ, Forbes SC, Batra A, Sweeney HL, Mendell JR, Vandenborne K, Walter GA. Leg muscle MRI in identical twin boys with Duchenne muscular dystrophy. Muscle & Nerve. PMID 29365354 DOI: 10.1002/Mus.26081  0.272
2001 Cordier L, Gao GP, Hack AA, McNally EM, Wilson JM, Chirmule N, Sweeney HL. Muscle-specific promoters may be necessary for adeno-associated virus-mediated gene transfer in the treatment of muscular dystrophies. Human Gene Therapy. 12: 205-15. PMID 11177557 DOI: 10.1089/104303401750061267  0.271
2005 Griffin MA, Feng H, Tewari M, Acosta P, Kawana M, Sweeney HL, Discher DE. gamma-Sarcoglycan deficiency increases cell contractility, apoptosis and MAPK pathway activation but does not affect adhesion. Journal of Cell Science. 118: 1405-16. PMID 15769854 DOI: 10.1242/Jcs.01717  0.271
1998 Sweeney HL, Rosenfeld SS, Brown F, Faust L, Smith J, Xing J, Stein LA, Sellers JR. Kinetic tuning of myosin via a flexible loop adjacent to the nucleotide binding pocket. The Journal of Biological Chemistry. 273: 6262-70. PMID 9497352 DOI: 10.1074/jbc.273.11.6262  0.27
2014 Nelson MD, Rader F, Tang X, Tavyev J, Nelson SF, Miceli MC, Elashoff RM, Sweeney HL, Victor RG. PDE5 inhibition alleviates functional muscle ischemia in boys with Duchenne muscular dystrophy. Neurology. 82: 2085-91. PMID 24808022 DOI: 10.1212/Wnl.0000000000000498  0.27
1999 Barton-Davis ER, Shoturma DI, Sweeney HL. Contribution of satellite cells to IGF-I induced hypertrophy of skeletal muscle Acta Physiologica Scandinavica. 167: 301-305. PMID 10632630 DOI: 10.1046/j.1365-201X.1999.00618.x  0.269
2001 Joel PB, Trybus KM, Sweeney HL. Two Conserved Lysines at the 50/20-kDa Junction of Myosin Are Necessary for Triggering Actin Activation Journal of Biological Chemistry. 276: 2998-3003. PMID 11042210 DOI: 10.1074/jbc.M006930200  0.268
2009 Reifenberger JG, Toprak E, Kim H, Safer D, Sweeney HL, Selvin PR. Myosin VI undergoes a 180 degrees power stroke implying an uncoupling of the front lever arm. Proceedings of the National Academy of Sciences of the United States of America. 106: 18255-60. PMID 19828438 DOI: 10.1073/Pnas.0900005106  0.267
2002 Purcell TJ, Morris C, Spudich JA, Sweeney HL. Role of the lever arm in the processive stepping of myosin V. Proceedings of the National Academy of Sciences of the United States of America. 99: 14159-64. PMID 12386339 DOI: 10.1073/Pnas.182539599  0.267
2000 Hack AA, Lam MY, Cordier L, Shoturma DI, Ly CT, Hadhazy MA, Hadhazy MR, Sweeney HL, McNally EM. Differential requirement for individual sarcoglycans and dystrophin in the assembly and function of the dystrophin-glycoprotein complex. Journal of Cell Science. 113: 2535-44. PMID 10862711  0.266
2011 Bish LT, Sleeper MM, Forbes SC, Morine KJ, Reynolds C, Singletary GE, Trafny D, Pham J, Bogan J, Kornegay JN, Vandenborne K, Walter GA, Sweeney HL. Long-term systemic myostatin inhibition via liver-targeted gene transfer in golden retriever muscular dystrophy Human Gene Therapy. 22: 1499-1509. PMID 21787232 DOI: 10.1089/Hum.2011.102  0.266
2012 Kuang SQ, Kwartler CS, Byanova KL, Pham J, Gong L, Prakash SK, Huang J, Kamm KE, Stull JT, Sweeney HL, Milewicz DM. Rare, nonsynonymous variant in the smooth muscle-specific isoform of myosin heavy chain, MYH11, R247C, alters force generation in the aorta and phenotype of smooth muscle cells. Circulation Research. 110: 1411-22. PMID 22511748 DOI: 10.1161/Circresaha.111.261743  0.266
2012 Lewis JH, Beausang JF, Sweeney HL, Goldman YE. The azimuthal path of myosin V and its dependence on lever-arm length. The Journal of General Physiology. 139: 101-20. PMID 22291144 DOI: 10.1085/Jgp.201110715  0.263
2005 Rock RS, Ramamurthy B, Dunn AR, Beccafico S, Rami BR, Morris C, Spink BJ, Franzini-Armstrong C, Spudich JA, Sweeney HL. A flexible domain is essential for the large step size and processivity of myosin VI. Molecular Cell. 17: 603-9. PMID 15721263 DOI: 10.1016/J.Molcel.2005.01.015  0.263
2015 Vohra RS, Lott D, Mathur S, Senesac C, Deol J, Germain S, Bendixen R, Forbes SC, Sweeney HL, Walter GA, Vandenborne K. Magnetic Resonance Assessment of Hypertrophic and Pseudo-Hypertrophic Changes in Lower Leg Muscles of Boys with Duchenne Muscular Dystrophy and Their Relationship to Functional Measurements. Plos One. 10: e0128915. PMID 26103164 DOI: 10.1371/Journal.Pone.0128915  0.262
2011 Krementsova EB, Hodges AR, Bookwalter CS, Sladewski TE, Travaglia M, Sweeney HL, Trybus KM. Two single-headed myosin V motors bound to a tetrameric adapter protein form a processive complex. The Journal of Cell Biology. 195: 631-41. PMID 22084309 DOI: 10.1083/jcb.201106146  0.262
2014 Wyatt EJ, Sweeney HL, McNally EM. Meeting Report: New Directions in Biology and Disease of Skeletal Muscle 2014. Journal of Neuromuscular Diseases. 1: 197-206. PMID 27858776  0.26
2014 Wyatt EJ, Sweeney HL, McNally EM. Meeting Report: New Directions in the Biology and Disease of Skeletal Muscle 2014. Journal of Neuromuscular Diseases. 1: 197-206. PMID 26207203 DOI: 10.3233/Jnd-149003  0.26
2005 Pathare N, Walter GA, Stevens JE, Yang Z, Okerke E, Gibbs JD, Esterhai JL, Scarborough MT, Gibbs CP, Sweeney HL, Vandenborne K. Changes in inorganic phosphate and force production in human skeletal muscle after cast immobilization. Journal of Applied Physiology (Bethesda, Md. : 1985). 98: 307-14. PMID 15333614 DOI: 10.1152/Japplphysiol.00612.2004  0.26
2018 Sweeney HL, Holzbaur ELF. Motor Proteins. Cold Spring Harbor Perspectives in Biology. 10. PMID 29716949 DOI: 10.1101/cshperspect.a021931  0.26
1998 Levine RJ, Yang Z, Epstein ND, Fananapazir L, Stull JT, Sweeney HL. Structural and functional responses of mammalian thick filaments to alterations in myosin regulatory light chains. Journal of Structural Biology. 122: 149-61. PMID 9724616 DOI: 10.1006/Jsbi.1998.3980  0.259
2019 Qin X, Man Cheng HC, Li J, Yoo H, Liu X, Lin T, Sweeney HL, Park H. Tracking of Labeled Motor Domains of Single Full-Length Myosin X on Actin Bundles Biophysical Journal. 116: 259a. DOI: 10.1016/J.Bpj.2018.11.1411  0.259
1998 Yang Z, Stull JT, Levine RJC, Sweeney HL. Changes in interfilament spacing mimic the effects of myosin regulatory light chain phosphorylation in rabbit psoas fibers Journal of Structural Biology. 122: 139-148. PMID 9724615 DOI: 10.1006/Jsbi.1998.3979  0.258
2004 Moise MA, Berry M, Grand T, Fisher O, Morris L, Kolakowski S, Hsu V, Cohen J, Sweeney H, Woo Y. GMCSF and SDF treatment induces neovasculogenesis in a mouse ischemic hindlimb model Journal of the American College of Surgeons. 199: 105. DOI: 10.1016/J.Jamcollsurg.2004.05.236  0.257
2001 Tikunov BA, Sweeney HL, Rome LC. Quantitative electrophoretic analysis of myosin heavy chains in single muscle fibers Journal of Applied Physiology. 90: 1927-1935. PMID 11299287 DOI: 10.1152/JAPPL.2001.90.5.1927  0.256
2023 Neyroud D, Laitano O, Dasgupta A, Lopez C, Schmitt RE, Schneider JZ, Hammers DW, Sweeney HL, Walter GA, Doles J, Judge SM, Judge AR. Blocking muscle wasting via deletion of the muscle-specific E3 ligase MuRF1 impedes pancreatic tumor growth. Communications Biology. 6: 519. PMID 37179425 DOI: 10.1038/s42003-023-04902-2  0.256
2010 Mathur S, Lott DJ, Senesac C, Germain SA, Vohra RS, Sweeney HL, Walter GA, Vandenborne K. Age-related differences in lower-limb muscle cross-sectional area and torque production in boys with Duchenne muscular dystrophy. Archives of Physical Medicine and Rehabilitation. 91: 1051-8. PMID 20599043 DOI: 10.1016/J.Apmr.2010.03.024  0.255
1994 Sweeney HL, Straceski AJ, Leinwand LA, Tikunov BA, Faust L. Heterologous expression of a cardiomyopathic myosin that is defective in its actin interaction. The Journal of Biological Chemistry. 269: 1603-5. PMID 8294404  0.255
2015 Castillero E, Akashi H, Wang C, Najjar M, Ji R, Kennel PJ, Sweeney HL, Schulze PC, George I. Cardiac myostatin upregulation occurs immediately after myocardial ischemia and is involved in skeletal muscle activation of atrophy. Biochemical and Biophysical Research Communications. 457: 106-11. PMID 25528587 DOI: 10.1016/j.bbrc.2014.12.057  0.254
2016 Hammers DW, Sleeper MM, Forbes SC, Coker CC, Jirousek MR, Zimmer M, Walter GA, Sweeney HL. Disease-modifying effects of orally bioavailable NF-κB inhibitors in dystrophin-deficient muscle. Jci Insight. 1: e90341. PMID 28018975 DOI: 10.1172/jci.insight.90341  0.254
2000 De La Cruz EM, Sweeney HL, Ostap EM. ADP inhibition of myosin V ATPase activity. Biophysical Journal. 79: 1524-9. PMID 10969013 DOI: 10.1016/S0006-3495(00)76403-4  0.254
1995 Lankford EB, Epstein ND, Fananapazir L, Sweeney HL. Abnormal contractile properties of muscle fibers expressing β-myosin heavy chain gene mutations in patients with hypertrophic cardiomyopathy Journal of Clinical Investigation. 95: 1409-1414. PMID 7883988 DOI: 10.1172/JCI117795  0.253
2023 Chen X, Arciola JM, Lee YI, Wong PHP, Yin H, Tao Q, Jin Y, Qin X, Sweeney HL, Park H. Myo10 tail is crucial for promoting long filopodia. The Journal of Biological Chemistry. 105523. PMID 38043799 DOI: 10.1016/j.jbc.2023.105523  0.252
2000 De La Cruz EM, Ostap EM, Brundage RA, Reddy KS, Sweeney HL, Safer D. Thymosin-beta(4) changes the conformation and dynamics of actin monomers. Biophysical Journal. 78: 2516-27. PMID 10777749 DOI: 10.1016/S0006-3495(00)76797-X  0.251
2014 Ermolova NV, Martinez L, Vetrone SA, Jordan MC, Roos KP, Sweeney HL, Spencer MJ. Long-term administration of the TNF blocking drug Remicade (cV1q) to mdx mice reduces skeletal and cardiac muscle fibrosis, but negatively impacts cardiac function. Neuromuscular Disorders : Nmd. 24: 583-95. PMID 24844454 DOI: 10.1016/j.nmd.2014.04.006  0.249
2016 Milewicz DM, Trybus KM, Guo D, Sweeney HL, Regalado E, Kamm K, Stull JT. Altered Smooth Muscle Cell Force Generation as a Driver of Thoracic Aortic Aneurysms and Dissections. Arteriosclerosis, Thrombosis, and Vascular Biology. PMID 27879251 DOI: 10.1161/Atvbaha.116.303229  0.248
1999 Ra HJ, Picart C, Feng H, Sweeney HL, Discher DE. Muscle cell peeling from micropatterned collagen: direct probing of focal and molecular properties of matrix adhesion. Journal of Cell Science. 112: 1425-36. PMID 10212137  0.248
1990 Farrar RP, Waiters TJ, Wilkinson K, Starnes JW, Sweeney HL. 813 INCREASING OXIDATIVE CAPACITY OF SKELETAL MUSCLE DOES NOT NECESSITATE AN INCREASE IN VO2 MAX Medicine & Science in Sports & Exercise. 22: S136. DOI: 10.1249/00005768-199004000-00812  0.247
2000 De La Cruz EM, Wells AL, Sweeney HL, Ostap EM. Actin and light chain isoform dependence of myosin V kinetics. Biochemistry. 39: 14196-202. PMID 11087368 DOI: 10.1021/Bi001701B  0.246
2011 Ali MY, Kennedy GG, Safer D, Trybus KM, Sweeney HL, Warshaw DM. Myosin Va and myosin VI coordinate their steps while engaged in an in vitro tug of war during cargo transport. Proceedings of the National Academy of Sciences of the United States of America. 108: E535-41. PMID 21808051 DOI: 10.1073/pnas.1104298108  0.244
2024 Hart CC, Lee YI, Xie J, Gao G, Lin BL, Hammers DW, Sweeney HL. Potential limitations of micro-dystrophin gene therapy for Duchenne muscular dystrophy. Jci Insight. PMID 38713520 DOI: 10.1172/jci.insight.165869  0.242
2014 Forbes SC, Willcocks RJ, Triplett WT, Rooney WD, Lott DJ, Wang DJ, Pollaro J, Senesac CR, Daniels MJ, Finkel RS, Russman BS, Byrne BJ, Finanger EL, Tennekoon GI, Walter GA, ... Sweeney HL, et al. Magnetic resonance imaging and spectroscopy assessment of lower extremity skeletal muscles in boys with Duchenne muscular dystrophy: a multicenter cross sectional study. Plos One. 9: e106435. PMID 25203313 DOI: 10.1371/Journal.Pone.0106435  0.241
2004 Ramamurthy B, Yengo CM, Straight AF, Mitchison TJ, Sweeney HL. Kinetic mechanism of blebbistatin inhibition of nonmuscle myosin IIb. Biochemistry. 43: 14832-9. PMID 15544354 DOI: 10.1021/Bi0490284  0.238
2009 Kim H, Mukherjea M, Sweeney HL, Selvin PR. The Medial-tail Domain of Myosin-VI as a Dimerization Region Biophysical Journal. 96: 140a. DOI: 10.1016/J.Bpj.2008.12.3875  0.238
2004 Griffin MA, Sen S, Sweeney HL, Discher DE. Adhesion-contractile balance in myocyte differentiation. Journal of Cell Science. 117: 5855-63. PMID 15522893 DOI: 10.1242/Jcs.01496  0.235
2022 Barnard AM, Hammers DW, Triplett WT, Kim S, Forbes SC, Willcocks RJ, Daniels MJ, Senesac CR, Lott DJ, Arpan I, Rooney WD, Wang RT, Nelson SF, Sweeney HL, Vandenborne K, et al. Evaluating Genetic Modifiers of Duchenne Muscular Dystrophy Disease Progression Using Modeling and MRI. Neurology. PMID 36240102 DOI: 10.1212/WNL.0000000000201163  0.233
2021 Finkel RS, Finanger E, Vandenborne K, Sweeney HL, Tennekoon G, Shieh PB, Willcocks R, Walter G, Rooney WD, Forbes SC, Triplett WT, Yum SW, Mancini M, MacDougall J, Fretzen A, et al. Disease-modifying effects of edasalonexent, an NF-κB inhibitor, in young boys with Duchenne muscular dystrophy: Results of the MoveDMD phase 2 and open label extension trial: Running title: Edasalonexent for Duchenne muscular dystrophy. Neuromuscular Disorders : Nmd. PMID 33678513 DOI: 10.1016/j.nmd.2021.02.001  0.232
2023 Nguyen QQ, Zhou Y, Cheng MS, Qin X, Cheng HCM, Liu X, Sweeney HL, Park H. The Antiparallel Coiled-Coil Domain Allows Multiple Forward Step Sizes of Myosin X. The Journal of Physical Chemistry Letters. 4914-4922. PMID 37202741 DOI: 10.1021/acs.jpclett.3c00512  0.232
2004 Walter GA, Cahill KS, Huard J, Feng H, Douglas T, Sweeney HL, Bulte JWM. Noninvasive Monitoring of Stem Cell Transfer for Muscle Disorders Magnetic Resonance in Medicine. 51: 273-277. PMID 14755651 DOI: 10.1002/Mrm.10684  0.23
2018 Shima A, Morimoto Y, Sweeney HL, Takeuchi S. Three-dimensional contractile muscle tissue consisting of human skeletal myocyte cell line. Experimental Cell Research. 370: 168-173. PMID 29928867 DOI: 10.1016/j.yexcr.2018.06.015  0.229
1996 Haecker SE, Stedman HH, Balice-Gordon RJ, Smith DB, Greelish JP, Mitchell MA, Wells A, Sweeney HL, Wilson JM. In vivo expression of full-length human dystrophin from adenoviral vectors deleted of all viral genes. Human Gene Therapy. 7: 1907-14. PMID 8894682 DOI: 10.1089/Hum.1996.7.15-1907  0.228
2024 Gandhi S, Sweeney HL, Hart CC, Han R, Perry CGR. Cardiomyopathy in Duchenne Muscular Dystrophy and the Potential for Mitochondrial Therapeutics to Improve Treatment Response. Cells. 13. PMID 39056750 DOI: 10.3390/cells13141168  0.227
2003 Morris CA, Wells AL, Yang Z, Chen LQ, Baldacchino CV, Sweeney HL. Calcium functionally uncouples the heads of myosin VI. The Journal of Biological Chemistry. 278: 23324-30. PMID 12682054 DOI: 10.1074/Jbc.M208957200  0.225
1991 Walters TJ, Sweeney HL, Farrar RP. Influence of electrical stimulation on a fast-twitch muscle in aging rats Journal of Applied Physiology. 71: 1921-1928. PMID 1761492 DOI: 10.1152/Jappl.1991.71.5.1921  0.223
2014 Sano S, Kodera N, Safer D, Sweeney HL, Ando T. 2P166 Direct observation of functioning myosin VI by high-speed AFM(11. Molecular motor,Poster,The 52nd Annual Meeting of the Biophysical Society of Japan(BSJ2014)) Seibutsu Butsuri. 54: S222. DOI: 10.2142/biophys.54.S222_4  0.221
2014 Arpan I, Willcocks RJ, Forbes SC, Finkel RS, Lott DJ, Rooney WD, Triplett WT, Senesac CR, Daniels MJ, Byrne BJ, Finanger EL, Russman BS, Wang DJ, Tennekoon GI, Walter GA, ... Sweeney HL, et al. Examination of effects of corticosteroids on skeletal muscles of boys with DMD using MRI and MRS. Neurology. 83: 974-80. PMID 25098537 DOI: 10.1212/Wnl.0000000000000775  0.217
2010 Ali MY, Nelson SR, Kennedy GG, Trybus KM, Sweeney HL, Warshaw DM. Myosin Va and Myosin VI Engage in a “Tug of War” on Actin Tracks while Transporting Cargoes in vitro Biophysical Journal. 98: 431a. DOI: 10.1016/j.bpj.2009.12.2338  0.217
2018 Barnard AM, Willcocks RJ, Finanger EL, Daniels MJ, Triplett WT, Rooney WD, Lott DJ, Forbes SC, Wang DJ, Senesac CR, Harrington AT, Finkel RS, Russman BS, Byrne BJ, Tennekoon GI, ... ... Sweeney HL, et al. Skeletal muscle magnetic resonance biomarkers correlate with function and sentinel events in Duchenne muscular dystrophy. Plos One. 13: e0194283. PMID 29554116 DOI: 10.1371/Journal.Pone.0194283  0.216
2009 Ali M, Trybus KM, Warshaw DM, Sweeney H. How Do Myosin VI and Myosin Va Navigate Intersections And Cooperate On Actin Tracks While Transporting Cargo In Vitro? Biophysical Journal. 96: 546a. DOI: 10.1016/j.bpj.2008.12.2955  0.212
2023 Höök P, Lee YI, Sweeney HL. Myosin VI powers self-organization of branched contractile actin network. Biochemical and Biophysical Research Communications. 691: 149329. PMID 38042035 DOI: 10.1016/j.bbrc.2023.149329  0.212
2004 Griffin MA, Engler AJ, Barber TA, Healy KE, Sweeney HL, Discher DE. Patterning, prestress, and peeling dynamics of myocytes. Biophysical Journal. 86: 1209-22. PMID 14747355 DOI: 10.1016/S0006-3495(04)74195-8  0.211
2000 Ojima K, Lin ZX, Bang M, Holtzer S, Matsuda R, Labeit S, Sweeney HL, Holtzer H. Distinct families of Z-line targeting modules in the COOH-terminal region of nebulin. The Journal of Cell Biology. 150: 553-66. PMID 10931867 DOI: 10.1083/jcb.150.3.553  0.206
2024 Poukalov KK, Valero MC, Muscato DR, Adams LM, Chun H, Lee YI, Andrade NS, Zeier Z, Sweeney HL, Wang ET. Myospreader improves gene editing in skeletal muscle by myonuclear propagation. Proceedings of the National Academy of Sciences of the United States of America. 121: e2321438121. PMID 38687782 DOI: 10.1073/pnas.2321438121  0.205
2023 Poukalov KK, Valero MC, Muscato DR, Adams LM, Chun H, Lee YI, Andrade NS, Zeier Z, Sweeney HL, Wang ET. Myospreader improves gene editing in skeletal muscle by myonuclear propagation. Biorxiv : the Preprint Server For Biology. PMID 37986992 DOI: 10.1101/2023.11.06.565807  0.205
2010 Krieger CC, Bhasin N, Tewari M, Brown AE, Safer D, Sweeney HL, Discher DE. Exon-skipped dystrophins for treatment of Duchenne muscular dystrophy: mass spectrometry mapping of most exons and cooperative domain designs based on single molecule mechanics. Cytoskeleton (Hoboken, N.J.). 67: 796-807. PMID 20886611 DOI: 10.1002/Cm.20489  0.204
2020 Rooney WD, Berlow YA, Triplett WT, Forbes SC, Willcocks RJ, Wang DJ, Arpan I, Arora H, Senesac C, Lott DJ, Tennekoon G, Finkel R, Russman BS, Finanger EL, Chakraborty S, ... ... Sweeney HL, et al. Modeling disease trajectory in Duchenne muscular dystrophy. Neurology. PMID 32184340 DOI: 10.1212/Wnl.0000000000009244  0.202
1988 Templeton GH, Sweeney HL, Timson BF, Padalino M, Dudenhoeffer GA. Changes in fiber composition of soleus muscle during rat hindlimb suspension Journal of Applied Physiology. 65: 1191-1195. PMID 2972672 DOI: 10.1152/jappl.1988.65.3.1191  0.2
2014 Castillero E, Akashi H, Ji R, Pendrak K, Najjar M, Sorabella R, Yerebakan H, Shiomi T, Wang C, Ali Z, Mancini D, D'Armiento J, Sweeney HL, Schulze PC, George I. MYOSTATIN INHIBITION AFTER EXPERIMENTAL HEART FAILURE IMPROVES CARDIAC FUNCTION AND MUSCLE WASTING Journal of the American College of Cardiology. 63: A767. DOI: 10.1016/S0735-1097(14)60767-1  0.2
2004 Altman D, Sweeney HL, Spudich JA. The mechanism of myosin VI translocation and its load-induced anchoring. Cell. 116: 737-49. PMID 15006355 DOI: 10.1016/S0092-8674(04)00211-9  0.2
1996 Sweeney HL, Holzbaur EL. Mutational analysis of motor proteins. Annual Review of Physiology. 58: 751-92. PMID 8815819 DOI: 10.1146/annurev.ph.58.030196.003535  0.198
2024 Patsalos A, Halasz L, Oleksak D, Wei X, Nagy G, Tzerpos P, Conrad T, Hammers DW, Sweeney HL, Nagy L. Spatiotemporal transcriptomic mapping of regenerative inflammation in skeletal muscle reveals a dynamic multilayered tissue architecture. The Journal of Clinical Investigation. PMID 39190487 DOI: 10.1172/JCI173858  0.197
2009 Zhang ZQ, Bish LT, Holtzer H, Sweeney HL. Sarcomeric-alpha-actinin defective in vinculin-binding causes Z-line expansion and nemaline-like body formation in cultured chick myotubes. Experimental Cell Research. 315: 748-59. PMID 19166831 DOI: 10.1016/j.yexcr.2008.12.019  0.195
2008 Alhopuro P, Phichith D, Tuupanen S, Sammalkorpi H, Nybondas M, Saharinen J, Robinson JP, Yang Z, Chen LQ, Orntoft T, Mecklin JP, Järvinen H, Eng C, Moeslein G, Shibata D, ... ... Sweeney HL, et al. Unregulated smooth-muscle myosin in human intestinal neoplasia. Proceedings of the National Academy of Sciences of the United States of America. 105: 5513-8. PMID 18391202 DOI: 10.1073/Pnas.0801213105  0.195
1989 Putkey JA, Sweeney HL, Campbell ST. Site-directed mutation of the trigger calcium-binding sites in cardiac troponin C Journal of Biological Chemistry. 264: 12370-12378. PMID 2745448  0.193
1996 Levine S, Tikunov B, Henson D, Lamanca J, Sweeney HL. Creatine depletion elicits structural, biochemical, and physiological adaptations in rat costal diaphragm American Journal of Physiology - Cell Physiology. 271. PMID 8944630 DOI: 10.1152/ajpcell.1996.271.5.C1480  0.192
2013 Gruntman AM, Bish LT, Mueller C, Sweeney HL, Flotte TR, Gao G. Gene transfer in skeletal and cardiac muscle using recombinant adeno-associated virus. Current Protocols in Microbiology. Unit 14D.3. PMID 23408131 DOI: 10.1002/9780471729259.Mc14D03S28  0.189
1994 Sweeney HL. The importance of the creatine kinase reaction: The concept of metabolic capacitance Medicine and Science in Sports and Exercise. 26: 30-36. PMID 8133735  0.188
2014 Willcocks RJ, Arpan IA, Forbes SC, Lott DJ, Senesac CR, Senesac E, Deol J, Triplett WT, Baligand C, Daniels MJ, Sweeney HL, Walter GA, Vandenborne K. Longitudinal measurements of MRI-T2 in boys with Duchenne muscular dystrophy: effects of age and disease progression. Neuromuscular Disorders : Nmd. 24: 393-401. PMID 24491484 DOI: 10.1016/J.Nmd.2013.12.012  0.187
1997 Watkins H, Seidman CE, Seidman JG, Feng HS, Sweeney HL. Expression and functional assessment of a truncated cardiac troponin T that causes hypertrophic cardiomyopathy. Evidence for a dominant negative action. The Journal of Clinical Investigation. 98: 2456-61. PMID 8958207 DOI: 10.1172/JCI119063  0.187
2006 Stevens JE, Borst SE, Li Y, Conover CF, Sweeney HL, Walter GA, Vandenborne K, White LJ. Insulin-like Growth Factor-1 Gene Transfer Augments Muscle IGF Protein Content Despite Cast Immobilization Medicine & Science in Sports & Exercise. 38: S52. DOI: 10.1249/00005768-200605001-01111  0.187
2013 Forbes SC, Walter GA, Rooney WD, Wang DJ, DeVos S, Pollaro J, Triplett W, Lott DJ, Willcocks RJ, Senesac C, Daniels MJ, Byrne BJ, Russman B, Finkel RS, Meyer JS, ... Sweeney HL, et al. Skeletal muscles of ambulant children with Duchenne muscular dystrophy: validation of multicenter study of evaluation with MR imaging and MR spectroscopy. Radiology. 269: 198-207. PMID 23696684 DOI: 10.1148/Radiol.13121948  0.186
2005 Stevens JE, Yarasheski KE, Li Y, Sweeney HL, Vandenborne K. Insulin-like Growth Factor-1 Gene Transfer Augments Muscle Protein Synthesis Rate And Size In Adult Mice Medicine & Science in Sports & Exercise. 37: S71???S72. DOI: 10.1097/00005768-200505001-00405  0.186
2005 Balci H, Ha T, Sweeney HL, Selvin PR. Interhead distance measurements in myosin VI via SHRImP support a simplified hand-over-hand model. Biophysical Journal. 89: 413-7. PMID 15863481 DOI: 10.1529/Biophysj.105.060608  0.185
1996 Sweeney HL. Molecular motors of eukaryotic cells Annual Review of Physiology. 58: 669-670. PMID 8815814  0.183
2005 Bhasin N, Law R, Liao G, Safer D, Ellmer J, Discher BM, Sweeney HL, Discher DE. Molecular extensibility of mini-dystrophins and a dystrophin rod construct. Journal of Molecular Biology. 352: 795-806. PMID 16139300 DOI: 10.1016/J.Jmb.2005.07.064  0.182
2012 Herson S, Hentati F, Rigolet A, Behin A, Romero NB, Leturcq F, Laforêt P, Maisonobe T, Amouri R, Haddad H, Audit M, Montus M, Masurier C, Gjata B, Georger C, ... ... Sweeney HL, et al. A phase I trial of adeno-associated virus serotype 1-γ-sarcoglycan gene therapy for limb girdle muscular dystrophy type 2C. Brain : a Journal of Neurology. 135: 483-92. PMID 22240777 DOI: 10.1093/Brain/Awr342  0.181
1997 Hijikata T, Lin ZX, Holtzer S, Choi J, Sweeney HL, Holtzer H. Unanticipated temporal and spatial effects of sarcomeric alpha-actinin peptides expressed in PtK2 cells. Cell Motility and the Cytoskeleton. 38: 54-74. PMID 9295141 DOI: 10.1002/(Sici)1097-0169(1997)38:1<54::Aid-Cm6>3.0.Co;2-H  0.179
1998 Sweeney HL, Feng HS, Yang Z, Watkins H. Functional analyses of troponin T mutations that cause hypertrophic cardiomyopathy: Insights into disease pathogenesis and troponin function Proceedings of the National Academy of Sciences of the United States of America. 95: 14406-14410. PMID 9826713 DOI: 10.1073/pnas.95.24.14406  0.178
2019 Castillero E, Akashi H, Najjar M, Ji R, Brandstetter LM, Wang C, Liao X, Zhang X, Sperry A, Gailes M, Guaman K, Recht A, Schlosberg I, Sweeney HL, Ali ZA, et al. Activin Type II Receptor Ligand Signaling Inhibition After Experimental Ischemic Heart Failure Attenuates Cardiac Remodeling and Prevents Fibrosis. American Journal of Physiology. Heart and Circulatory Physiology. PMID 31886717 DOI: 10.1152/Ajpheart.00302.2019  0.175
2015 Duan D, Hakim CH, Ambrosio CE, Smith BF, Sweeney HL. Early loss of ambulation is not a representative clinical feature in Duchenne muscular dystrophy dogs: remarks on the article of Barthélémy et al. Disease Models & Mechanisms. 8: 193-4. PMID 25740329 DOI: 10.1242/Dmm.019216  0.172
2012 Bish LT, Sleeper MM, Forbes SC, Wang B, Reynolds C, Singletary GE, Trafny D, Morine KJ, Sanmiguel J, Cecchini S, Virag T, Vulin A, Beley C, Bogan J, Wilson JM, ... ... Sweeney HL, et al. Long-term restoration of cardiac dystrophin expression in golden retriever muscular dystrophy following rAAV6-mediated exon skipping. Molecular Therapy : the Journal of the American Society of Gene Therapy. 20: 580-9. PMID 22146342 DOI: 10.1038/Mt.2011.264  0.162
1997 Sweeney HL, Feng H. Structure-function analysis of cytoskeletal/contractile proteins in avian myotubes. Methods in Cell Biology. 52: 275-82. PMID 9379954  0.158
2024 Carraro U, Alberty MS, Anton S, Barbieri E, Bersch I, Blaauw B, Bosco G, Forni R, Ganassi M, Gargiulo P, Gentil P, Gorgey AS, Leeuwenburgh C, Maccarone MC, Martini A, ... ... Sweeney HL, et al. Mobility Medicine: A call to unify hyper-fragmented specialties by abstracts sent to 2025Pdm3, and typescripts to Ejtm3, and . European Journal of Translational Myology. 34. PMID 39665691 DOI: 10.4081/ejtm.2024.13432  0.158
2010 Bish LT, Morine KJ, Sleeper MM, Sweeney HL. Myostatin is upregulated following stress in an Erk-dependent manner and negatively regulates cardiomyocyte growth in culture and in a mouse model Plos One. 5. PMID 20419100 DOI: 10.1371/journal.pone.0010230  0.156
1998 Lin Z, Hijikata T, Zhang Z, Choi J, Holtzer S, Sweeney HL, Holtzer H. Dispensability of the actin-binding site and spectrin repeats for targeting sarcomeric alpha-actinin into maturing Z bands in vivo: implications for in vitro binding studies. Developmental Biology. 199: 291-308. PMID 9698448 DOI: 10.1006/Dbio.1998.8920  0.155
2022 Hart CC, Lee YI, Hammers DW, Sweeney HL. Evaluation of the DBA/2J mouse as a potential background strain for genetic models of cardiomyopathy. Journal of Molecular and Cellular Cardiology Plus. 1. PMID 37206988 DOI: 10.1016/j.jmccpl.2022.100012  0.151
2020 Forbes SC, Arora H, Willcocks RJ, Triplett WT, Rooney WD, Barnard AM, Alabasi U, Wang DJ, Lott DJ, Senesac CR, Harrington AT, Finanger EL, Tennekoon GI, Brandsema J, Daniels MJ, ... Sweeney HL, et al. Upper and Lower Extremities in Duchenne Muscular Dystrophy Evaluated with Quantitative MRI and Proton MR Spectroscopy in a Multicenter Cohort. Radiology. 192210. PMID 32286193 DOI: 10.1148/Radiol.2020192210  0.149
2011 Bish LT, George I, Maybaum S, Yang J, Chen JM, Sweeney HL. Myostatin is elevated in congenital heart disease and after mechanical unloading. Plos One. 6: e23818. PMID 21931616 DOI: 10.1371/journal.pone.0023818  0.149
2016 Willcocks RJ, Rooney WD, Triplett WT, Forbes SC, Lott DJ, Senesac CR, Daniels MJ, Wang DJ, Harrington AT, Tennekoon GI, Russman BS, Finanger EL, Byrne BJ, Finkel RS, Walter GA, ... Sweeney HL, et al. Multicenter prospective longitudinal study of magnetic resonance biomarkers in a large duchenne muscular dystrophy cohort. Annals of Neurology. PMID 26891991 DOI: 10.1002/Ana.24599  0.147
1994 Yu KR, Hijikata T, Lin ZX, Sweeney HL, Englander SW, Holtzer H. Truncated desmin in PtK2 cells induces desmin-vimentin-cytokeratin coprecipitation, involution of intermediate filament networks, and nuclear fragmentation: a model for many degenerative diseases. Proceedings of the National Academy of Sciences of the United States of America. 91: 2497-501. PMID 7511811 DOI: 10.1073/Pnas.91.7.2497  0.139
2023 Zampieri S, Bersch I, Smeriglio P, Barbieri E, Ganassi M, Leeuwenburg C, Rosati R, Gargiulo P, Pond A, Sweeney HL, Carraro U. Five Padua days on muscle and mobility medicine (2024Pdm3) 27 February - 2 March, 2024 at Hotel Petrarca, Thermae of Euganean Hills, Padua, and San Luca Hall, Prato della Valle, Padua, Italy. European Journal of Translational Myology. 33. PMID 38112609 DOI: 10.4081/ejtm.2023.12161  0.138
2018 Daniel B, Nagy G, Czimmerer Z, Horvath A, Hammers DW, Cuaranta-Monroy I, Poliska S, Tzerpos P, Kolostyak Z, Hays TT, Patsalos A, Houtman R, Sauer S, Francois-Deleuze J, Rastinejad F, ... ... Sweeney HL, et al. The Nuclear Receptor PPARγ Controls Progressive Macrophage Polarization as a Ligand-Insensitive Epigenomic Ratchet of Transcriptional Memory. Immunity. 49: 615-626.e6. PMID 30332629 DOI: 10.1016/J.Immuni.2018.09.005  0.138
2023 Willcocks RJ, Barnard AM, Daniels MJ, Forbes SC, Triplett WT, Brandsema JF, Finanger EL, Rooney WD, Kim S, Wang DJ, Lott DJ, Senesac CR, Walter GA, Sweeney HL, Vandenborne K. Clinical importance of changes in magnetic resonance biomarkers for Duchenne muscular dystrophy. Annals of Clinical and Translational Neurology. PMID 37932907 DOI: 10.1002/acn3.51933  0.136
1998 Spindler M, Saupe KW, Christe ME, Sweeney HL, Seidman CE, Seidman JG, Ingwall JS. Diastolic dysfunction and altered energetics in the alphaMHC403/+ mouse model of familial hypertrophic cardiomyopathy. The Journal of Clinical Investigation. 101: 1775-83. PMID 9541509 DOI: 10.1172/JCI1940  0.136
1990 Sweeney HL. 680 INTERACTIONS BETWEEN FREQUENCY, LENGTH, AND TENSION IN MOTOR UNITS OF VARYING SPEEDS A. G. Nelson Medicine & Science in Sports & Exercise. 22: S114. DOI: 10.1249/00005768-199004000-00679  0.135
2006 Engler AJ, Sen S, Sweeney HL, Discher DE. Matrix elasticity directs stem cell lineage specification. Cell. 126: 677-89. PMID 16923388 DOI: 10.1016/J.Cell.2006.06.044  0.129
1999 Ojima K, Lin ZX, Zhang ZQ, Hijikata T, Holtzer S, Labeit S, Sweeney HL, Holtzer H. Initiation and maturation of I-Z-I bodies in the growth tips of transfected myotubes. Journal of Cell Science. 112: 4101-12. PMID 10547369  0.128
2018 Castillero E, Ali ZA, Akashi H, Giangreco N, Wang C, Stöhr EJ, Ji R, Zhang X, Kheysin N, Park JS, Hegde S, Patel S, Stein S, Cuenca C, Leung D, ... ... Sweeney HL, et al. Structural and Functional Cardiac Profile after Prolonged Duration of Mechanical Unloading: Potential Implications for Myocardial Recovery. American Journal of Physiology. Heart and Circulatory Physiology. PMID 30141986 DOI: 10.1152/Ajpheart.00187.2018  0.127
2006 Berry MF, Engler AJ, Woo YJ, Pirolli TJ, Bish LT, Jayasankar V, Morine KJ, Gardner TJ, Discher DE, Sweeney HL. Mesenchymal stem cell injection after myocardial infarction improves myocardial compliance. American Journal of Physiology. Heart and Circulatory Physiology. 290: H2196-203. PMID 16473959 DOI: 10.1152/Ajpheart.01017.2005  0.124
2014 Triplett WT, Baligand C, Forbes SC, Willcocks RJ, Lott DJ, DeVos S, Pollaro J, Rooney WD, Sweeney HL, Bönnemann CG, Wang DJ, Vandenborne K, Walter GA. Chemical shift-based MRI to measure fat fractions in dystrophic skeletal muscle. Magnetic Resonance in Medicine. 72: 8-19. PMID 24006208 DOI: 10.1002/Mrm.24917  0.122
1997 Holtzer H, Hijikata T, Lin ZX, Zhang ZQ, Holtzer S, Protasi F, Franzini-Armstrong C, Sweeney HL. Independent assembly of 1.6 microns long bipolar MHC filaments and I-Z-I bodies. Cell Structure and Function. 22: 83-93. PMID 9113394 DOI: 10.1247/Csf.22.83  0.12
2025 Radnai L, Young EJ, Kikuti C, Toth K, Zhou M, Hafenbreidel M, Stremel RF, Lin L, Pasetto P, Jin X, Patel A, Conlon M, Briggs SB, Heidsieck L, Sweeney HL, et al. Development of clinically viable non-muscle myosin II small molecule inhibitors. Cell. PMID 40602401 DOI: 10.1016/j.cell.2025.06.006  0.12
2011 Bish LT, Sleeper MM, Reynolds C, Gazzara J, Withnall E, Singletary GE, Buchlis G, Hui D, High KA, Gao G, Wilson JM, Sweeney HL. Cardiac gene transfer of short hairpin RNA directed against phospholamban effectively knocks down gene expression but causes cellular toxicity in canines. Human Gene Therapy. 22: 969-77. PMID 21542669 DOI: 10.1089/Hum.2011.035  0.12
2013 Chen SJ, Johnston J, Sandhu A, Bish LT, Hovhannisyan R, Jno-Charles O, Sweeney HL, Wilson JM. Enhancing the utility of adeno-associated virus gene transfer through inducible tissue-specific expression. Human Gene Therapy Methods. 24: 270-8. PMID 23895325 DOI: 10.1089/Hgtb.2012.129  0.118
2015 Castillero E, Akashi H, Pendrak K, Yerebakan H, Najjar M, Wang C, Naka Y, Mancini DM, Sweeney HL, D'Armiento JM, Ali ZA, Schulze PC, George I. Attenuation of the Unfolded Protein Response and Endoplasmic Reticulum Stress after Mechanical Unloading in Dilated Cardiomyopathy. American Journal of Physiology. Heart and Circulatory Physiology. ajpheart.00056.2015. PMID 26055788 DOI: 10.1152/ajpheart.00056.2015  0.117
2009 Sleeper MM, Bish LT, Sweeney HL. Gene therapy in large animal models of human cardiovascular genetic disease Ilar Journal. 50: 199-205. PMID 19293462  0.117
2008 Bish LT, Morine K, Sleeper MM, Sanmiguel J, Wu D, Gao G, Wilson JM, Sweeney HL. Adeno-associated virus (AAV) serotype 9 provides global cardiac gene transfer superior to AAV1, AAV6, AAV7, and AAV8 in the mouse and rat. Human Gene Therapy. 19: 1359-68. PMID 18795839 DOI: 10.1089/Hum.2008.123  0.116
2013 Finkel RS, Flanigan KM, Wong B, Bönnemann C, Sampson J, Sweeney HL, Reha A, Northcutt VJ, Elfring G, Barth J, Peltz SW. Phase 2a study of ataluren-mediated dystrophin production in patients with nonsense mutation Duchenne muscular dystrophy. Plos One. 8: e81302. PMID 24349052 DOI: 10.1371/Journal.Pone.0081302  0.114
2011 Gao G, Bish LT, Sleeper MM, Mu X, Sun L, Lou Y, Duan J, Hu C, Wang L, Sweeney HL. Transendocardial delivery of AAV6 results in highly efficient and global cardiac gene transfer in rhesus macaques. Human Gene Therapy. 22: 979-84. PMID 21563985 DOI: 10.1089/Hum.2011.042  0.112
2009 Zhang ZQ, Bish LT, Holtzer H, Sweeney HL. Corrigendum to "Sarcomeric-alpha-actinin defective in vinculin-binding causes Z-line expansion and nemaline-like body formation in cultured chick myotubes" [Experimental Cell Research 315 (2009) 748-759] (DOI:10.1016/j.yexcr.2008.12.019) Experimental Cell Research. 315: 2140. DOI: 10.1016/j.yexcr.2009.04.010  0.11
2016 Hammers DW, Sleeper MM, Forbes SC, Shima A, Walter GA, Sweeney HL. Tadalafil Treatment Delays the Onset of Cardiomyopathy in Dystrophin-Deficient Hearts. Journal of the American Heart Association. 5. PMID 27506543 DOI: 10.1161/JAHA.116.003911  0.109
2010 Sleeper MM, Bish LT, Sweeney HL. Status of therapeutic gene transfer to treat canine dilated cardiomyopathy in dogs Veterinary Clinics of North America - Small Animal Practice. 40: 717-724. PMID 20610021 DOI: 10.1016/j.cvsm.2010.03.005  0.106
2022 Sweeney HL, Masiero S, Carraro U. The 2022 On-site Padua Days on Muscle and Mobility Medicine hosts the University of Florida Institute of Myology and the Wellstone Center, March 30 - April 3, 2022 at the University of Padua and Thermae of Euganean Hills, Padua, Italy: The collection of abstracts. European Journal of Translational Myology. 32. PMID 35272451 DOI: 10.4081/ejtm.2022.10440  0.106
2017 McDonald CM, Campbell C, Torricelli RE, Finkel RS, Flanigan KM, Goemans N, Heydemann P, Kaminska A, Kirschner J, Muntoni F, Osorio AN, Schara U, Sejersen T, Shieh PB, Sweeney HL, et al. Ataluren in patients with nonsense mutation Duchenne muscular dystrophy (ACT DMD): a multicentre, randomised, double-blind, placebo-controlled, phase 3 trial. Lancet (London, England). PMID 28728956 DOI: 10.1016/S0140-6736(17)31611-2  0.105
2006 Cohen JE, Atluri P, Taylor MD, Grand TJ, Liao GP, Panlilio CM, Suarez EE, Zentko SE, Hsu VM, Berry MF, Smith MJ, Gardner TJ, Sweeney HL, Woo YJ. Fructose 1,6-diphosphate administration attenuates post-ischemic ventricular dysfunction. Heart, Lung & Circulation. 15: 119-23. PMID 16469539 DOI: 10.1016/j.hlc.2005.12.004  0.102
1998 Zhang JC, Woo Y, Chen J, Swain JL, Sweeney H. Efficient transmural cardiac gene transfer by intrapericardial injection in neonatal mice Journal of Cardiac Failure. 4: 22. DOI: 10.1016/S1071-9164(98)90079-3  0.101
2005 Woo YJ, Zhang JC, Taylor MD, Cohen JE, Hsu VM, Sweeney HL. One year transgene expression with adeno-associated virus cardiac gene transfer. International Journal of Cardiology. 100: 421-6. PMID 15837086 DOI: 10.1016/j.ijcard.2004.09.003  0.099
1988 Farrar RP, Starnes JW, Cartee GD, Oh PY, Sweeney HL. Effects of exercise on cardiac myosin isozyme composition during the aging process Journal of Applied Physiology. 64: 880-883. PMID 2967277 DOI: 10.1152/Jappl.1988.64.2.880  0.096
2011 Bish LT, Sweeney HL, Müller OJ, Bekeredjian R. Adeno-associated virus vector delivery to the heart. Methods in Molecular Biology (Clifton, N.J.). 807: 219-37. PMID 22034032 DOI: 10.1007/978-1-61779-370-7_9  0.095
2000 Zhu HL, Stewart AS, Taylor MD, Vijayasarathy C, Gardner TJ, Sweeney HL. Blocking free radical production via adenoviral gene transfer decreases cardiac ischemia-reperfusion injury. Molecular Therapy : the Journal of the American Society of Gene Therapy. 2: 470-5. PMID 11082320 DOI: 10.1006/mthe.2000.0193  0.095
2014 Wilson FP, Xie D, Anderson AH, Leonard MB, Reese PP, Delafontaine P, Horwitz E, Kallem R, Navaneethan S, Ojo A, Porter AC, Sondheimer JH, Sweeney HL, Townsend RR, Feldman HI, et al. Urinary creatinine excretion, bioelectrical impedance analysis, and clinical outcomes in patients with CKD: the CRIC study. Clinical Journal of the American Society of Nephrology : Cjasn. 9: 2095-103. PMID 25381342 DOI: 10.2215/Cjn.03790414  0.094
2025 Cox D, Byrne B, Hammers DW, Landry J, Sweeney HL. Effect of Tadalafil on cardiac function and left ventricular dimensions in Duchenne muscular dystrophy: safety and cardiac MRI substudy results from a randomized, placebo-controlled trial. Bmc Cardiovascular Disorders. 25: 276. PMID 40217158 DOI: 10.1186/s12872-025-04727-3  0.093
2015 Hathout Y, Brody E, Clemens PR, Cripe L, DeLisle RK, Furlong P, Gordish-Dressman H, Hache L, Henricson E, Hoffman EP, Kobayashi YM, Lorts A, Mah JK, McDonald C, Mehler B, ... ... Sweeney HL, et al. Large-scale serum protein biomarker discovery in Duchenne muscular dystrophy. Proceedings of the National Academy of Sciences of the United States of America. 112: 7153-8. PMID 26039989 DOI: 10.1073/Pnas.1507719112  0.092
2009 Peltz SW, Welch EM, Jacobson A, Trotta CR, Naryshkin N, Sweeney HL, Bedwell DM. Nonsense suppression activity of PTC124 (ataluren). Proceedings of the National Academy of Sciences of the United States of America. 106: E64; author reply E6. PMID 19506240 DOI: 10.1073/Pnas.0901936106  0.091
1998 Woo YJ, Zhang JC, Vijayasarathy C, Zwacka RM, Englehardt JF, Gardner TJ, Sweeney HL. Recombinant adenovirus-mediated cardiac gene transfer of superoxide dismutase and catalase attenuates postischemic contractile dysfunction. Circulation. 98: II255-60; discussion. PMID 9852911  0.091
2011 Sleeper M, Bish LT, Haskins M, Ponder KP, Sweeney HL. Status of therapeutic gene transfer to treat cardiovascular disease in dogs and cats. Journal of Veterinary Cardiology : the Official Journal of the European Society of Veterinary Cardiology. 13: 131-40. PMID 21640678 DOI: 10.1016/j.jvc.2011.04.001  0.09
2011 Bish LT, Sleeper MM, Sweeney HL. Percutaneous transendocardial delivery of self-complementary adeno-associated virus 6 in the canine Methods in Molecular Biology (Clifton, N.J.). 709: 369-378. PMID 21194041 DOI: 10.1007/978-1-61737-982-6_24  0.09
2008 Bish LT, Sleeper MM, Brainard B, Cole S, Russell N, Withnall E, Arndt J, Reynolds C, Davison E, Sanmiguel J, Wu D, Gao G, Wilson JM, Sweeney HL. Percutaneous transendocardial delivery of self-complementary adeno-associated virus 6 achieves global cardiac gene transfer in canines. Molecular Therapy : the Journal of the American Society of Gene Therapy. 16: 1953-9. PMID 18813281 DOI: 10.1038/mt.2008.202  0.089
2018 Arora H, Willcocks RJ, Lott DJ, Harrington AT, Senesac CR, Zilke KL, Daniels MJ, Xu D, Tennekoon GI, Finanger EL, Russman BS, Finkel RS, Triplett WT, Byrne BJ, Walter GA, ... Sweeney HL, et al. Longitudinal timed function tests in Duchenne muscular dystrophy: ImagingDMD cohort natural history. Muscle & Nerve. PMID 29742798 DOI: 10.1002/Mus.26161  0.088
2021 Pham K, Maxwell MJ, Sweeney H, Alt J, Rais R, Eberhart CG, Slusher BS, Raabe EH. Novel Glutamine Antagonist JHU395 Suppresses MYC-Driven Medulloblastoma Growth and Induces Apoptosis. Journal of Neuropathology and Experimental Neurology. PMID 33712838 DOI: 10.1093/jnen/nlab018  0.086
2024 McDonald C, Camino E, Escandon R, Finkel RS, Fischer R, Flanigan K, Furlong P, Juhasz R, Martin AS, Villa C, Sweeney HL. Draft Guidance for Industry Duchenne Muscular Dystrophy, Becker Muscular Dystrophy, and Related Dystrophinopathies - Developing Potential Treatments for the Entire Spectrum of Disease. Journal of Neuromuscular Diseases. PMID 38363616 DOI: 10.3233/JND-230219  0.085
2020 Yang Y, Wu ZP, Shu Y, Sweeney HL, Huang B. [Pathophysiological Study on Thoracic Ascending Aorta of Mice with 11 Heterozygous Mutation in Norepinephrine-induced Hypertension Model]. Sichuan Da Xue Xue Bao. Yi Xue Ban = Journal of Sichuan University. Medical Science Edition. 51: 200-206. PMID 32220188 DOI: 10.12182/20200360102  0.085
2021 Maxwell MJ, Arnold A, Sweeney H, Chen L, Lih TM, Schnaubelt M, Eberhart CG, Rubens JA, Zhang H, Clark DJ, Raabe EH. Unbiased proteomic and phosphoproteomic analysis identifies response signatures and novel susceptibilities after combined MEK and mTOR inhibition in BRAF mutant glioma. Molecular & Cellular Proteomics : McP. 100123. PMID 34298159 DOI: 10.1016/j.mcpro.2021.100123  0.084
2006 Atluri P, Liao GP, Panlilio CM, Hsu VM, Leskowitz MJ, Morine KJ, Cohen JE, Berry MF, Suarez EE, Murphy DA, Lee WM, Gardner TJ, Sweeney HL, Woo YJ. Neovasculogenic therapy to augment perfusion and preserve viability in ischemic cardiomyopathy. The Annals of Thoracic Surgery. 81: 1728-36. PMID 16631663 DOI: 10.1016/j.athoracsur.2005.12.015  0.08
2020 Barnard AM, Willcocks RJ, Triplett WT, Forbes SC, Daniels MJ, Chakraborty S, Lott DJ, Senesac CR, Finanger EL, Harrington AT, Tennekoon G, Arora H, Wang DJ, Sweeney HL, Rooney WD, et al. MR biomarkers predict clinical function in Duchenne muscular dystrophy. Neurology. PMID 32024675 DOI: 10.1212/Wnl.0000000000009012  0.078
2020 Shahab S, Rubens J, Kaur H, Sweeney H, Eberhart CG, Raabe EH. MEK Inhibition Suppresses Growth of Atypical Teratoid/Rhabdoid Tumors. Journal of Neuropathology and Experimental Neurology. PMID 32472116 DOI: 10.1093/Jnen/Nlaa042  0.075
2016 Castillero E, Ji R, Wu S, Akashi H, Wang C, Ali Z, Sweeney HL, Schulze PC, George I. INCREASED MYOSTATIN IS ASSOCIATED WITH DECREASED AMPK AND WORSENED CARDIAC FUNCTION IN HEART FAILURE WITH PREVIOUS INSULIN RESISTANCE Journal of the American College of Cardiology. 67: 1400. DOI: 10.1016/S0735-1097(16)31401-2  0.073
2010 George I, Bish LT, Kamalakkannan G, Petrilli CM, Oz MC, Naka Y, Sweeney HL, Maybaum S. Myostatin activation in patients with advanced heart failure and after mechanical unloading. European Journal of Heart Failure. 12: 444-53. PMID 20348550 DOI: 10.1093/eurjhf/hfq039  0.073
2018 Aartsma-Rus A, Ferlini A, McNally EM, Spitali P, Sweeney HL. 226th ENMC International Workshop:: Towards validated and qualified biomarkers for therapy development for Duchenne muscular dystrophy 20-22 January 2017, Heemskerk, The Netherlands. Neuromuscular Disorders : Nmd. 28: 77-86. PMID 29203356 DOI: 10.1016/J.Nmd.2017.10.002  0.072
2002 Chatterjee S, Stewart AS, Bish LT, Jayasankar V, Kim EM, Pirolli T, Burdick J, Woo YJ, Gardner TJ, Sweeney HL. Viral gene transfer of the antiapoptotic factor Bcl-2 protects against chronic postischemic heart failure. Circulation. 106: I212-7. PMID 12354736  0.072
2003 Jayasankar V, Woo YJ, Bish LT, Pirolli TJ, Chatterjee S, Berry MF, Burdick J, Gardner TJ, Sweeney HL. Gene transfer of hepatocyte growth factor attenuates postinfarction heart failure. Circulation. 108: II230-6. PMID 12970238 DOI: 10.1161/01.cir.0000087444.53354.66  0.07
1972 Magill CW, Sweeney H, Woodward VW. Histidine uptake in strains of Neurospora crassa with normal and mutant transport systems Journal of Bacteriology. 110: 313-320. PMID 4259665 DOI: 10.1128/Jb.110.1.313-320.1972  0.069
2015 Furlong P, Bridges JF, Charnas L, Fallon JR, Fischer R, Flanigan KM, Franson TR, Gulati N, McDonald C, Peay H, Sweeney HL. How a patient advocacy group developed the first proposed draft guidance document for industry for submission to the U.S. Food and Drug Administration. Orphanet Journal of Rare Diseases. 10: 82. PMID 26104810 DOI: 10.1186/s13023-015-0281-2  0.063
2000 Stewart A, Bish L, Brinster D, Sweeney H, Gardner T. Cardiac gene transfer of HGF is superior to TMR in inducing therapeutic coronary neoangiogenesis Journal of the American College of Surgeons. 191: S38. DOI: 10.1016/S1072-7515(00)00486-5  0.063
2005 Jayasankar V, Woo YJ, Pirolli TJ, Bish LT, Berry MF, Burdick J, Gardner TJ, Sweeney HL. Induction of angiogenesis and inhibition of apoptosis by hepatocyte growth factor effectively treats postischemic heart failure. Journal of Cardiac Surgery. 20: 93-101. PMID 15673421 DOI: 10.1111/j.0886-0440.2005.200373.x  0.063
2004 Jayasankar V, Woo YJ, Bish LT, Pirolli TJ, Berry MF, Burdick J, Bhalla RC, Sharma RV, Gardner TJ, Sweeney HL. Inhibition of matrix metalloproteinase activity by TIMP-1 gene transfer effectively treats ischemic cardiomyopathy. Circulation. 110: II180-6. PMID 15364860 DOI: 10.1161/01.Cir.0000138946.29375.49  0.059
2004 Berry MF, Woo YJ, Pirolli TJ, Bish LT, Moise MA, Burdick JW, Morine KJ, Jayasankar V, Gardner TJ, Sweeney HL. Administration of a tumor necrosis factor inhibitor at the time of myocardial infarction attenuates subsequent ventricular remodeling. The Journal of Heart and Lung Transplantation : the Official Publication of the International Society For Heart Transplantation. 23: 1061-8. PMID 15454172 DOI: 10.1016/j.healun.2004.06.021  0.058
2014 Castillero E, kashi H, Yerebakan H, Sorabella R, Najjar M, Pendrak K, Wang C, Ali Z, Mancini D, D'rmiento J, Sweeney HL, Schulze PC, George I. DIFFERING PATTERNS OF MYOSTATIN SIGNALING REGULATE HYPERTROPHY IN SEVERE AORTIC STENOSIS AND HYPERTROPHIC CARDIOMYOPATHY Journal of the American College of Cardiology. 63: A954. DOI: 10.1016/S0735-1097(14)60954-2  0.057
2005 Woo YJ, Grand TJ, Berry MF, Atluri P, Moise MA, Hsu VM, Cohen J, Fisher O, Burdick J, Taylor M, Zentko S, Liao G, Smith M, Kolakowski S, Jayasankar V, ... ... Sweeney HL, et al. Stromal cell-derived factor and granulocyte-monocyte colony-stimulating factor form a combined neovasculogenic therapy for ischemic cardiomyopathy. The Journal of Thoracic and Cardiovascular Surgery. 130: 321-9. PMID 16077394 DOI: 10.1016/J.Jtcvs.2004.11.041  0.055
2017 Victor RG, Sweeney HL, Finkel R, McDonald CM, Byrne B, Eagle M, Goemans N, Vandenborne K, Dubrovsky AL, Topaloglu H, Miceli MC, Furlong P, Landry J, Elashoff R, Cox D, et al. A phase 3 randomized placebo-controlled trial of tadalafil for Duchenne muscular dystrophy. Neurology. PMID 28972192 DOI: 10.1212/Wnl.0000000000004570  0.054
2007 Engler AJ, Sweeney HL, Discher DE, Schwarzbauer JE. Extracellular matrix elasticity directs stem cell differentiation. Journal of Musculoskeletal & Neuronal Interactions. 7: 335. PMID 18094500  0.052
2015 Castillero E, Akashi H, Ji R, Wang C, Ali Z, Sweeney HL, Schulze PC, George I. MYOSTATIN INHIBITION IMPROVES CARDIAC GLUCOSE METABOLISM IN A MURINE MODEL OF HEART FAILURE Journal of the American College of Cardiology. 65: A1626. DOI: 10.1016/S0735-1097(15)61626-6  0.052
2005 Atluri P, Liao G, Panlilio C, Morine K, Berry M, Hsu V, Cohen J, Suarez E, Smith M, Sweeney HL, Woo YJ. Treatment with granulocyte monocyte colony stimulating factor and stromal cell derived factor-1alpha enhances endothelial progenitor cell mediated myocardial perfusion and viability in ischemic cardiomyopathy Journal of the American College of Surgeons. 201: S44. DOI: 10.1016/j.jamcollsurg.2005.06.093  0.05
2022 Pham K, Hanaford AR, Poore BA, Maxwell MJ, Sweeney H, Parthasarathy A, Alt J, Rais R, Slusher BS, Eberhart CG, Raabe EH. Comprehensive Metabolic Profiling of MYC-Amplified Medulloblastoma Tumors Reveals Key Dependencies on Amino Acid, Tricarboxylic Acid and Hexosamine Pathways. Cancers. 14. PMID 35267619 DOI: 10.3390/cancers14051311  0.046
2017 Collum SD, Chen NY, Hernandez AM, Hanmandlu A, Sweeney H, Mertens TCJ, Weng T, Luo F, Molina JG, Davies J, Horan IP, Morrell NW, Amione-Guerra J, Al-Jabbari O, Youker K, et al. Inhibition of Hyaluronan Synthesis Attenuates Pulmonary Hypertension Associated with Lung Fibrosis. British Journal of Pharmacology. PMID 28688167 DOI: 10.1111/Bph.13947  0.043
2004 Berry M, Pirolli T, Bish L, Moise M, Burdick J, Morine K, Jayasankar V, Gardner T, Sweeney H, Woo Y. TNF inhibition at the time of myocardial infarction attenuates the subsequent development of heart failure The Journal of Heart and Lung Transplantation. 23: S174. DOI: 10.1016/J.HEALUN.2003.11.392  0.042
2004 Sweeney HL. Gene doping. Scientific American. 291: 62-9. PMID 15255589 DOI: 10.1038/scientificamerican0704-62  0.041
2009 Sweeney HL. Editorial [Suppression of Premature Stop Codons for the Treatment of a Subset of Patients with Genetic Disorders] Journal of Medical Sciences. 2: 1-4. DOI: 10.2174/1996327000902010001  0.04
2015 Castillero E, Akashi H, Ji R, Wang C, Ali Z, Sweeney HL, Schulze PC, George I. MYOSTATIN INHIBITION IMPROVES CARDIAC GLUCOSE METABOLISM IN A MURINE MODEL OF OBESITY Journal of the American College of Cardiology. 65: A1009. DOI: 10.1016/S0735-1097(15)61009-9  0.037
2008 Sweeney H, Rzepski B, Hochman H, Kim C, Lerer T, Ferrer F. Identifying characteristics of children requiring sedation for urodynamics. Urologic Nursing. 28: 269-72. PMID 18771161  0.034
1996 de Wildt G, Sweeney H. Moving away from rational medicine? Bmj (Clinical Research Ed.). 312: 1367. PMID 11644783  0.031
2022 Parker CC, James ND, Brawley CD, Clarke NW, Ali A, Amos CL, Attard G, Chowdhury S, Cook A, Cross W, Dearnaley DP, Douis H, Gilbert DC, Gilson C, Gillessen S, ... ... Sweeney H, et al. Radiotherapy to the prostate for men with metastatic prostate cancer in the UK and Switzerland: Long-term results from the STAMPEDE randomised controlled trial. Plos Medicine. 19: e1003998. PMID 35671327 DOI: 10.1371/journal.pmed.1003998  0.029
2023 Tavakoli A, Donovan K, Sweeney H, Uquillas K, Gordon B. Inpatient Buprenorphine Induction for Opioid Use Disorder in Pregnancy. Cureus. 15: e36376. PMID 37090287 DOI: 10.7759/cureus.36376  0.027
1997 Subramanian S, Goker H, Kanji A, Sweeney H. Clinical adrenal insufficiency in patients receiving megestrol therapy Archives of Internal Medicine. 157: 1008-1011. PMID 9140272  0.027
2000 Sweeney H, Pelegano J. Wilms tumor in a child with trisomy 13 Journal of Pediatric Hematology/Oncology. 22: 171-172. PMID 10779034 DOI: 10.1097/00043426-200003000-00018  0.026
2004 Albright JP, Powell JW, Martindale A, Black R, Crowley E, Schmidt P, Monroe J, Locy D, Aggler T, Davis WR, Salvaterra G, Miller D, Helwig D, Soboroff S, Nivens J, ... ... Sweeney H, et al. Injury patterns in big ten conference football. The American Journal of Sports Medicine. 32: 1394-404. PMID 15310563 DOI: 10.1177/0363546504264159  0.02
2014 Sweeney H, Willcocks R, Forbes S, Rooney W, Arpan I, Triplett W, Daniels M, Lott D, Senesac C, Finkel R, Byrne B, Finanger E, RussmanBS B, Wang D, Tennekoon G, et al. O15 Emerging results from the Imaging DMD study Neuromuscular Disorders. 24: S5. DOI: 10.1016/S0960-8966(14)70016-1  0.018
1965 COHEN S, SWEENEY H, LEITNER F. TEMPERATURE-SENSITIVE REPRESSION OF STAPHYLOCOCCAL PENICILLINASE. Science (New York, N.Y.). 149: 877-9. PMID 14332852  0.015
2008 Sweeney H, Marai S, Kim C, Ferrer F. Creating a sedation service for pediatric urodynamics: our experience. Urologic Nursing. 28: 273-8. PMID 18771162  0.01
2006 Sweeney H. Delayed presentation of posterior urethral valves in a child with autism. Urologic Nursing. 26: 71, 76. PMID 16562391  0.01
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