Dorothee Kern, Ph.D. - Publications

Affiliations: 
Biochemistry Brandeis University, Waltham, MA, United States 
Area:
enzymology, NMR

57 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2019 Zorba A, Nguyen V, Koide A, Hoemberger M, Zheng Y, Kutter S, Kim C, Koide S, Kern D. Allosteric modulation of a human protein kinase with monobodies. Proceedings of the National Academy of Sciences of the United States of America. PMID 31239342 DOI: 10.1073/pnas.1906024116  0.44
2018 Pitsawong W, Buosi V, Otten R, Agafonov RV, Zorba A, Kern N, Kutter S, Kern G, Pádua RA, Meniche X, Kern D. Dynamics of human protein kinase Aurora A linked to drug selectivity. Elife. 7. PMID 29901437 DOI: 10.7554/eLife.36656  0.52
2018 Otten R, Liu L, Kenner LR, Clarkson MW, Mavor D, Tawfik DS, Kern D, Fraser JS. Rescue of conformational dynamics in enzyme catalysis by directed evolution. Nature Communications. 9: 1314. PMID 29615624 DOI: 10.1038/s41467-018-03562-9  0.4
2016 Nguyen V, Wilson C, Hoemberger M, Stiller JB, Agafonov RV, Kutter S, English J, Theobald DL, Kern D. Evolutionary drivers of thermoadaptation in enzyme catalysis. Science (New York, N.Y.). PMID 28008087 DOI: 10.1126/science.aah3717  0.44
2016 Eichner T, Kutter S, Labeikovsky W, Buosi V, Kern D. Molecular mechanism of Pin1-tau recognition and catalysis. Journal of Molecular Biology. PMID 26996941 DOI: 10.1016/j.jmb.2016.03.009  0.44
2016 Kutter S, Eichner T, Deaconescu AM, Kern D. Regulation of microtubule assembly by tau and not by Pin1. Journal of Molecular Biology. PMID 26996940 DOI: 10.1016/j.jmb.2016.03.010  0.44
2015 Chakrabarti KS, Agafonov RV, Pontiggia F, Otten R, Higgins MK, Schertler GF, Oprian DD, Kern D. Conformational Selection in a Protein-Protein Interaction Revealed by Dynamic Pathway Analysis. Cell Reports. PMID 26725117 DOI: 10.1016/j.celrep.2015.12.010  1
2015 Pontiggia F, Pachov DV, Clarkson MW, Villali J, Hagan MF, Pande VS, Kern D. Free energy landscape of activation in a signalling protein at atomic resolution. Nature Communications. 6: 7284. PMID 26073309 DOI: 10.1038/ncomms8284  0.44
2015 Wilson C, Agafonov RV, Hoemberger M, Kutter S, Zorba A, Halpin J, Buosi V, Otten R, Waterman D, Theobald DL, Kern D. Kinase dynamics. Using ancient protein kinases to unravel a modern cancer drug's mechanism. Science (New York, N.Y.). 347: 882-6. PMID 25700521 DOI: 10.1126/science.aaa1823  1
2015 Kerns SJ, Agafonov RV, Cho YJ, Pontiggia F, Otten R, Pachov DV, Kutter S, Phung LA, Murphy PN, Thai V, Alber T, Hagan MF, Kern D. The energy landscape of adenylate kinase during catalysis. Nature Structural & Molecular Biology. 22: 124-31. PMID 25580578 DOI: 10.1038/nsmb.2941  1
2015 Pontiggia F, Pachov DV, Clarkson MW, Villali J, Hagan MF, Pande VS, Kern D. Free energy landscape of activation in a signalling protein at atomic resolution Nature Communications. 6. DOI: 10.1038/ncomms8284  1
2015 Hass MAS, Liu WM, Agafonov RV, Otten R, Phung LA, Schilder JT, Kern D, Ubbink M. A minor conformation of a lanthanide tag on adenylate kinase characterized by paramagnetic relaxation dispersion NMR spectroscopy Journal of Biomolecular Nmr. 61: 123-136. DOI: 10.1007/s10858-014-9894-3  1
2014 Agafonov RV, Wilson C, Otten R, Buosi V, Kern D. Energetic dissection of Gleevec's selectivity toward human tyrosine kinases. Nature Structural & Molecular Biology. 21: 848-53. PMID 25218445 DOI: 10.1038/nsmb.2891  1
2014 Zorba A, Buosi V, Kutter S, Kern N, Pontiggia F, Cho YJ, Kern D. Molecular mechanism of Aurora A kinase autophosphorylation and its allosteric activation by TPX2. Elife. 3: e02667. PMID 24867643  0.44
2014 Villali J, Pontiggia F, Clarkson MW, Hagan MF, Kern D. Evidence against the "Y-T coupling" mechanism of activation in the response regulator NtrC. Journal of Molecular Biology. 426: 1554-67. PMID 24406745 DOI: 10.1016/j.jmb.2013.12.027  1
2014 Zorba A, Buosi V, Kutter S, Kern N, Pontiggia F, Cho YJ, Kern D. Molecular mechanism of Aurora A kinase autophosphorylation and its allosteric activation by TPX2 Elife. 2014. DOI: 10.7554/eLife.02667.001  1
2013 Ranaghan MJ, Kumar RP, Chakrabarti KS, Buosi V, Kern D, Oprian DD. A highly conserved cysteine of neuronal calcium-sensing proteins controls cooperative binding of Ca2+ to recoverin. The Journal of Biological Chemistry. 288: 36160-7. PMID 24189072 DOI: 10.1074/jbc.M113.524355  1
2013 Park JM, Hu JH, Milshteyn A, Zhang PW, Moore CG, Park S, Datko MC, Domingo RD, Reyes CM, Wang XJ, Etzkorn FA, Xiao B, Szumlinski KK, Kern D, Linden DJ, et al. A prolyl-isomerase mediates dopamine-dependent plasticity and cocaine motor sensitization. Cell. 154: 637-50. PMID 23911326 DOI: 10.1016/j.cell.2013.07.001  1
2012 Morrison EA, DeKoster GT, Dutta S, Vafabakhsh R, Clarkson MW, Bahl A, Kern D, Ha T, Henzler-Wildman KA. Antiparallel EmrE exports drugs by exchanging between asymmetric structures. Nature. 481: 45-50. PMID 22178925 DOI: 10.1038/nature10703  1
2010 Otten R, Villali J, Kern D, Mulder FA. Probing microsecond time scale dynamics in proteins by methyl (1)H Carr-Purcell-Meiboom-Gill relaxation dispersion NMR measurements. Application to activation of the signaling protein NtrC(r). Journal of the American Chemical Society. 132: 17004-14. PMID 21058670 DOI: 10.1021/ja107410x  1
2010 Villali J, Kern D. Choreographing an enzyme's dance. Current Opinion in Chemical Biology. 14: 636-43. PMID 20822946 DOI: 10.1016/j.cbpa.2010.08.007  1
2010 Bosco DA, Eisenmesser EZ, Clarkson MW, Wolf-Watz M, Labeikovsky W, Millet O, Kern D. Dissecting the microscopic steps of the cyclophilin A enzymatic cycle on the biological HIV-1 capsid substrate by NMR. Journal of Molecular Biology. 403: 723-38. PMID 20708627 DOI: 10.1016/j.jmb.2010.08.001  1
2009 Gardino AK, Villali J, Kivenson A, Lei M, Liu CF, Steindel P, Eisenmesser EZ, Labeikovsky W, Wolf-Watz M, Clarkson MW, Kern D. Transient non-native hydrogen bonds promote activation of a signaling protein. Cell. 139: 1109-18. PMID 20005804 DOI: 10.1016/j.cell.2009.11.022  1
2009 Fraser JS, Clarkson MW, Degnan SC, Erion R, Kern D, Alber T. Hidden alternative structures of proline isomerase essential for catalysis Nature. 462: 669-673. PMID 19956261 DOI: 10.1038/nature08615  1
2009 Shim S, Yuan JP, Kim JY, Zeng W, Huang G, Milshteyn A, Kern D, Muallem S, Ming GL, Worley PF. Peptidyl-prolyl isomerase FKBP52 controls chemotropic guidance of neuronal growth cones via regulation of TRPC1 channel opening. Neuron. 64: 471-83. PMID 19945390 DOI: 10.1016/j.neuron.2009.09.025  1
2009 Clarkson MW, Lei M, Eisenmesser EZ, Labeikovsky W, Redfield A, Kern D. Mesodynamics in the SARS nucleocapsid measured by NMR field cycling. Journal of Biomolecular Nmr. 45: 217-25. PMID 19641854 DOI: 10.1007/s10858-009-9347-6  1
2009 Lei M, Velos J, Gardino A, Kivenson A, Karplus M, Kern D. Segmented transition pathway of the signaling protein nitrogen regulatory protein C. Journal of Molecular Biology. 392: 823-36. PMID 19576227 DOI: 10.1016/j.jmb.2009.06.065  1
2008 Thai V, Renesto P, Fowler CA, Brown DJ, Davis T, Gu W, Pollock DD, Kern D, Raoult D, Eisenmesser EZ. Structural, biochemical, and in vivo characterization of the first virally encoded cyclophilin from the Mimivirus. Journal of Molecular Biology. 378: 71-86. PMID 18342330 DOI: 10.1016/j.jmb.2007.08.051  1
2007 Henzler-Wildman K, Kern D. Dynamic personalities of proteins Nature. 450: 964-972. PMID 18075575 DOI: 10.1038/nature06522  1
2007 Henzler-Wildman KA, Lei M, Thai V, Kerns SJ, Karplus M, Kern D. A hierarchy of timescales in protein dynamics is linked to enzyme catalysis. Nature. 450: 913-6. PMID 18026087 DOI: 10.1038/nature06407  1
2007 Henzler-Wildman KA, Thai V, Lei M, Ott M, Wolf-Watz M, Fenn T, Pozharski E, Wilson MA, Petsko GA, Karplus M, Hübner CG, Kern D. Intrinsic motions along an enzymatic reaction trajectory. Nature. 450: 838-44. PMID 18026086 DOI: 10.1038/nature06410  1
2007 Gardino AK, Kern D. Functional dynamics of response regulators using NMR relaxation techniques. Methods in Enzymology. 423: 149-65. PMID 17609130 DOI: 10.1016/S0076-6879(07)23006-X  1
2007 Labeikovsky W, Eisenmesser EZ, Bosco DA, Kern D. Structure and dynamics of pin1 during catalysis by NMR. Journal of Molecular Biology. 367: 1370-81. PMID 17316687 DOI: 10.1016/j.jmb.2007.01.049  1
2005 Wemmer DE, Kern D. Beryllofluoride binding mimics phosphorylation of aspartate in response regulators. Journal of Bacteriology. 187: 8229-30. PMID 16321925 DOI: 10.1128/JB.187.24.8229-8230.2005  1
2005 Wemmer DE, Kern D. Rebuttal: conformational changes of Spo0F along the phosphotransfer pathway. Journal of Bacteriology. 187: 8228. PMID 16321924 DOI: 10.1128/JB.187.24.8228.2005  1
2005 Eisenmesser EZ, Millet O, Labeikovsky W, Korzhnev DM, Wolf-Watz M, Bosco DA, Skalicky JJ, Kay LE, Kern D. Intrinsic dynamics of an enzyme underlies catalysis. Nature. 438: 117-21. PMID 16267559 DOI: 10.1038/nature04105  1
2005 Tittmann K, Neef H, Golbik R, Hübner G, Kern D. Kinetic control of thiamin diphosphate activation in enzymes studied by proton-nitrogen correlated NMR spectroscopy. Biochemistry. 44: 8697-700. PMID 15952776 DOI: 10.1021/bi050522x  1
2005 Kern D, Eisenmesser EZ, Wolf-Watz M. Enzyme dynamics during catalysis measured by NMR spectroscopy. Methods in Enzymology. 394: 507-24. PMID 15808235 DOI: 10.1016/S0076-6879(05)94021-4  1
2004 Wolf-Watz M, Thai V, Henzler-Wildman K, Hadjipavlou G, Eisenmesser EZ, Kern D. Linkage between dynamics and catalysis in a thermophilic-mesophilic enzyme pair Nature Structural and Molecular Biology. 11: 945-949. PMID 15334070 DOI: 10.1038/nsmb821  1
2004 Bosco DA, Kern D. Catalysis and binding of cyclophilin A with different HIV-1 capsid constructs. Biochemistry. 43: 6110-9. PMID 15147195 DOI: 10.1021/bi049841z  1
2003 Kern D, Zuiderweg ER. The role of dynamics in allosteric regulation. Current Opinion in Structural Biology. 13: 748-57. PMID 14675554 DOI: 10.1016/j.sbi.2003.10.008  1
2003 Gardino AK, Volkman BF, Cho HS, Lee SY, Wemmer DE, Kern D. The NMR solution structure of BeF(3)(-)-activated Spo0F reveals the conformational switch in a phosphorelay system. Journal of Molecular Biology. 331: 245-54. PMID 12875849 DOI: 10.1016/S0022-2836(03)00733-2  1
2002 Kern D. Cutting the leash. Nature Structural Biology. 9: 496-7. PMID 12080334 DOI: 10.1038/nsb0702-496  1
2002 Kern G, Pelton J, Marqusee S, Kern D. Structural properties of the histidine-containing loop in HIV-1 RNase H. Biophysical Chemistry. 96: 285-91. PMID 12034447 DOI: 10.1016/S0301-4622(02)00019-4  1
2002 Bosco DA, Eisenmesser EZ, Pochapsky S, Sundquist WI, Kern D. Catalysis of cis/trans isomerization in native HIV-1 capsid by human cyclophilin A. Proceedings of the National Academy of Sciences of the United States of America. 99: 5247-52. PMID 11929983 DOI: 10.1073/pnas.082100499  1
2002 Eisenmesser EZ, Bosco DA, Akke M, Kern D. Enzyme dynamics during catalysis. Science (New York, N.Y.). 295: 1520-3. PMID 11859194 DOI: 10.1126/science.1066176  1
2001 Volkman BF, Lipson D, Wemmer DE, Kern D. Two-state allosteric behavior in a single-domain signaling protein. Science (New York, N.Y.). 291: 2429-33. PMID 11264542 DOI: 10.1126/science.291.5512.2429  1
1999 Kern D, Volkman BF, Luginbühl P, Nohaile MJ, Kustu S, Wemmer DE. Structure of a transiently phosphorylated switch in bacterial signal transduction. Nature. 402: 894-8. PMID 10622255 DOI: 10.1038/47273  1
1998 Hübner G, Tittmann K, Killenberg-Jabs M, Schäffner J, Spinka M, Neef H, Kern D, Kern G, Schneider G, Wikner C, Ghisla S. Activation of thiamin diphosphate in enzymes Biochimica Et Biophysica Acta - Protein Structure and Molecular Enzymology. 1385: 221-228. PMID 9655909 DOI: 10.1016/S0167-4838(98)00070-3  1
1997 Nohaile M, Kern D, Wemmer D, Stedman K, Kustu S. Structural and functional analyses of activating amino acid substitutions in the receiver domain of NtrC: Evidence for an activating surface Journal of Molecular Biology. 273: 299-316. PMID 9367763 DOI: 10.1006/jmbi.1997.1296  1
1997 Kern D, Kern G, Neef H, Tittmann K, Killenberg-Jabs M, Wikner C, Schneider G, Hübner G. How thiamine diphosphate is activated in enzymes Science. 275: 67-70. PMID 8974393 DOI: 10.1126/science.275.5296.67  1
1997 Kern D, Schutkowski M, Drakenberg T. Rotational barriers of cis/trans isomerization of proline analogues and their catalysis by cyclophilin Journal of the American Chemical Society. 119: 8403-8408. DOI: 10.1021/ja970606w  1
1995 Kern G, Kern D, Schmid FX, Fischer G. A kinetic analysis of the folding of human carbonic anhydrase II and its catalysis by cyclophilin Journal of Biological Chemistry. 270: 740-745. PMID 7822304 DOI: 10.1074/jbc.270.2.740  1
1995 Kern D, Kern G, Scherer G, Fischer G, Drakenberg T. Kinetic analysis of cyclophilin-catalyzed prolyl cis/trans isomerization by dynamic NMR spectroscopy Biochemistry. 34: 13594-13602. PMID 7577948  1
1994 Kern G, Kern D, Schmid FX, Fischer G. Reassessment of the putative chaperone function of prolyl-cis/trans-isomerases Febs Letters. 348: 145-148. PMID 7913447 DOI: 10.1016/0014-5793(94)00591-5  1
1993 Kern D, Drakenberg T, Wikström M, Forsén S, Bang H, Fischer G. The cis/trans interconversion of the calcium regulating hormone calcitonin is catalyzed by cyclophilin Febs Letters. 323: 198-202. PMID 8500610 DOI: 10.1016/0014-5793(93)81338-Z  1
1993 Kern G, Kern D, Jaenicke R, Seckler R. Kinetics of folding and association of differently glycosylated variants of invertase from Saccharomyces cerevisiae Protein Science. 2: 1862-1868. PMID 8268797  1
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