| Year |
Citation |
Score |
| 2022 |
Fleming IR, Hannan JP, Swisher GH, Tesdahl CD, Martyr JG, Cordaro NJ, Erbse AH, Falke JJ. Binding of active Ras and its mutants to the Ras binding domain of PI-3-kinase: A quantitative approach to K measurements. Analytical Biochemistry. 663: 115019. PMID 36526022 DOI: 10.1016/j.ab.2022.115019 |
0.722 |
|
| 2021 |
Gordon MT, Ziemba BP, Falke JJ. Single-molecule studies reveal regulatory interactions between master kinases PDK1, AKT1, and PKC. Biophysical Journal. PMID 34673053 DOI: 10.1016/j.bpj.2021.10.015 |
0.327 |
|
| 2021 |
Hannan JP, Swisher GH, Martyr JG, Cordaro NJ, Erbse AH, Falke JJ. HPLC method to resolve, identify and quantify guanine nucleotides bound to recombinant ras GTPase. Analytical Biochemistry. 114338. PMID 34433016 DOI: 10.1016/j.ab.2021.114338 |
0.724 |
|
| 2021 |
Swisher GH, Hannan JP, Cordaro NJ, Erbse AH, Falke JJ. Ras-Guanine Nucleotide Complexes: A UV Spectral Deconvolution Method to Analyze Protein Concentration, Nucleotide Stoichiometry, and Purity. Analytical Biochemistry. 114066. PMID 33485819 DOI: 10.1016/j.ab.2020.114066 |
0.725 |
|
| 2020 |
Buckles TC, Ohashi Y, Tremel S, McLaughlin SH, Pardon E, Steyaert J, Gordon M, Williams RL, Falke JJ. Regulation of a Class III PI3K Lipid Kinase (VPS34 Complex II) by the Small G Protein Rab5A: Single Molecule Analysis Reveals a Dual Regulatory Mechanism. Biophysical Journal. PMID 33137306 DOI: 10.1016/j.bpj.2020.10.028 |
0.352 |
|
| 2020 |
Gordon MT, Falke JJ. Direct Detection and Characterization of a Phosphoinositide Dependent Kinase-1 (PDK1) Homodimer on a Target Membrane Surface Via Single Molecule Fluorescence Biophysical Journal. 118. DOI: 10.1016/J.Bpj.2019.11.3046 |
0.359 |
|
| 2020 |
Falke JJ, Ziemba BP, Buckles TC, Williams RL, Masson G. Regulatory Mechanisms of Ca2+, Receptor, Ras, and Lipid Signals that Control Actin Polymerization During Cell Migration Biophysical Journal. 118. DOI: 10.1016/J.Bpj.2019.11.268 |
0.354 |
|
| 2018 |
Ziemba BP, Falke JJ. A PKC-MARCKS-PI3K regulatory module links Ca2+ and PIP3 signals at the leading edge of polarized macrophages. Plos One. 13: e0196678. PMID 29715315 DOI: 10.1371/Journal.Pone.0196678 |
0.406 |
|
| 2017 |
Buckles TC, Ziemba BP, Masson GR, Williams RL, Falke JJ. Single-Molecule Study Reveals How Receptor and Ras Synergistically Activate PI3Kα and PIP3 Signaling. Biophysical Journal. 113: 2396-2405. PMID 29211993 DOI: 10.1016/J.Bpj.2017.09.018 |
0.433 |
|
| 2017 |
Buckles T, Ziemba B, Burke JE, Masson G, Williams R, Falke JJ. Activation of PI3K by Ras: Single Molecule Studies of the Activation Mechanism Biophysical Journal. 112. DOI: 10.1016/J.Bpj.2016.11.2135 |
0.367 |
|
| 2017 |
Ziemba BP, Falke JJ. Single Molecule Studies of a Membrane-Bound, Master Kinase Circuit... Detecting Interactions of Two Master Kinase Pairs on the Membrane, PDK1-AKT1 and PDK1-PKC Alpha Biophysical Journal. 112. DOI: 10.1016/J.Bpj.2016.11.2129 |
0.432 |
|
| 2016 |
Ziemba BP, Swisher GH, Masson G, Burke JE, Williams RL, Falke JJ. Regulation of a Coupled MARCKS-PI3K Lipid Kinase Circuit by Calmodulin: Single-Molecule Analysis of a Membrane-Bound Signaling Module. Biochemistry. 55: 6395-6405. PMID 27933776 DOI: 10.1021/Acs.Biochem.6B00908 |
0.469 |
|
| 2016 |
Ziemba BP, Burke JE, Masson G, Williams RL, Falke JJ. Regulation of PI3K by PKC and MARCKS: Single-Molecule Analysis of a Reconstituted Signaling Pathway. Biophysical Journal. 110: 1811-25. PMID 27119641 DOI: 10.1016/J.Bpj.2016.03.001 |
0.46 |
|
| 2015 |
Parkinson JS, Hazelbauer GL, Falke JJ. Signaling and sensory adaptation in Escherichia coli chemoreceptors: 2015 update. Trends in Microbiology. 23: 257-66. PMID 25834953 DOI: 10.1016/J.Tim.2015.03.003 |
0.398 |
|
| 2015 |
Balboa M, Turvey M, Falke J, Piasta K, Hurley M. Monovalent Cation Dependence on the Kinase Activity of Salmonella Typhimurium CheA: Experiment and Modeling Biophysical Journal. 108: 533a. DOI: 10.1016/J.Bpj.2014.11.2922 |
0.783 |
|
| 2015 |
Falke JJ, Piasta KN, Balboa M, Duplantis J, Swisher H, Turvey M. Disulfide Trapping and Spectroscopic Studies of Bacterial Chemosensory Core Signaling Complexes: Probing Molecular Mechanisms of Complex Assembly and Receptor-Regulated On-Off Switching Biophysical Journal. 108: 42a. DOI: 10.1016/J.Bpj.2014.11.256 |
0.808 |
|
| 2014 |
Falke JJ, Piasta KN. Architecture and signal transduction mechanism of the bacterial chemosensory array: progress, controversies, and challenges. Current Opinion in Structural Biology. 29: 85-94. PMID 25460272 DOI: 10.1016/J.Sbi.2014.10.001 |
0.766 |
|
| 2014 |
Falke JJ. Piston versus scissors: chemotaxis receptors versus sensor His-kinase receptors in two-component signaling pathways. Structure (London, England : 1993). 22: 1219-20. PMID 25185823 DOI: 10.1016/J.Str.2014.08.011 |
0.396 |
|
| 2014 |
Piasta KN, Falke JJ. Increasing and decreasing the ultrastability of bacterial chemotaxis core signaling complexes by modifying protein-protein contacts. Biochemistry. 53: 5592-600. PMID 25119814 DOI: 10.1021/Bi500849P |
0.791 |
|
| 2014 |
Li J, Ziemba BP, Falke JJ, Voth GA. Interactions of protein kinase C-α C1A and C1B domains with membranes: a combined computational and experimental study. Journal of the American Chemical Society. 136: 11757-66. PMID 25075641 DOI: 10.1021/Ja505369R |
0.484 |
|
| 2014 |
Briegel A, Wong ML, Hodges HL, Oikonomou CM, Piasta KN, Harris MJ, Fowler DJ, Thompson LK, Falke JJ, Kiessling LL, Jensen GJ. New insights into bacterial chemoreceptor array structure and assembly from electron cryotomography. Biochemistry. 53: 1575-85. PMID 24580139 DOI: 10.1021/Bi5000614 |
0.782 |
|
| 2014 |
Ziemba BP, Li J, Landgraf KE, Knight JD, Voth GA, Falke JJ. Single-molecule studies reveal a hidden key step in the activation mechanism of membrane-bound protein kinase C-α. Biochemistry. 53: 1697-713. PMID 24559055 DOI: 10.1021/Bi4016082 |
0.841 |
|
| 2014 |
Falke JJ, Ziemba BP. Interplay between phosphoinositide lipids and calcium signals at the leading edge of chemotaxing ameboid cells. Chemistry and Physics of Lipids. 182: 73-9. PMID 24451847 DOI: 10.1016/J.Chemphyslip.2014.01.002 |
0.4 |
|
| 2014 |
Briegel A, Wong ML, Hodges HL, Oikonomou CM, Piasta KN, Harris MJ, Fowler DJ, Thompson LK, Falke JJ, Kiessling LL, Jensen GJ. Correction to New Insights into Bacterial Chemoreceptor Array Structure and Assembly from Electron Cryotomography Biochemistry. 53: 6624-6624. DOI: 10.1021/Bi501167J |
0.744 |
|
| 2014 |
Piasta KN, Falke JJ. Increasing and decreasing the ultrastability of bacterial chemotaxis core signaling complexes by modifying protein-protein contacts Biochemistry. 53: 5592-5600. DOI: 10.1021/bi500849p |
0.76 |
|
| 2014 |
Falke JJ, Piasta KN. Architecture and signal transduction mechanism of the bacterial chemosensory array: Progress, controversies, and challenges Current Opinion in Structural Biology. 29: 85-94. DOI: 10.1016/j.sbi.2014.10.001 |
0.744 |
|
| 2014 |
Ziemba BP, Falke JJ. Single Molecule Studies of PKCα Activation Mechanism on Membrane Surfaces Biophysical Journal. 106. DOI: 10.1016/J.Bpj.2013.11.2867 |
0.493 |
|
| 2013 |
Natale AM, Duplantis JL, Piasta KN, Falke JJ. Structure, function, and on-off switching of a core unit contact between CheA kinase and CheW adaptor protein in the bacterial chemosensory array: A disulfide mapping and mutagenesis study. Biochemistry. 52: 7753-65. PMID 24090207 DOI: 10.1021/Bi401159K |
0.808 |
|
| 2013 |
Lai CL, Srivastava A, Pilling C, Chase AR, Falke JJ, Voth GA. Molecular mechanism of membrane binding of the GRP1 PH domain. Journal of Molecular Biology. 425: 3073-90. PMID 23747485 DOI: 10.1016/J.Jmb.2013.05.026 |
0.481 |
|
| 2013 |
Ziemba BP, Pilling C, Calleja V, Larijani B, Falke JJ. The PH domain of phosphoinositide-dependent kinase-1 exhibits a novel, phospho-regulated monomer-dimer equilibrium with important implications for kinase domain activation: single-molecule and ensemble studies. Biochemistry. 52: 4820-9. PMID 23745598 DOI: 10.1021/Bi400488F |
0.441 |
|
| 2013 |
Ziemba BP, Falke JJ. Lateral diffusion of peripheral membrane proteins on supported lipid bilayers is controlled by the additive frictional drags of (1) bound lipids and (2) protein domains penetrating into the bilayer hydrocarbon core. Chemistry and Physics of Lipids. 172: 67-77. PMID 23701821 DOI: 10.1016/J.Chemphyslip.2013.04.005 |
0.442 |
|
| 2013 |
Li X, Fleetwood AD, Bayas C, Bilwes AM, Ortega DR, Falke JJ, Zhulin IB, Crane BR. The 3.2 Å resolution structure of a receptor: CheA:CheW signaling complex defines overlapping binding sites and key residue interactions within bacterial chemosensory arrays. Biochemistry. 52: 3852-65. PMID 23668907 DOI: 10.1021/Bi400383E |
0.442 |
|
| 2013 |
Piasta KN, Ulliman CJ, Slivka PF, Crane BR, Falke JJ. Defining a key receptor-CheA kinase contact and elucidating its function in the membrane-bound bacterial chemosensory array: a disulfide mapping and TAM-IDS Study. Biochemistry. 52: 3866-80. PMID 23668882 DOI: 10.1021/Bi400385C |
0.828 |
|
| 2013 |
Brandt DS, Coffman MD, Falke JJ, Knight JD. Correction to Hydrophobic Contributions to the Membrane Docking of Synaptotagmin 7 C2A Domain: Mechanistic Contrast between Isoforms 1 and 7 Biochemistry. 52: 1649-1649. DOI: 10.1021/Bi400134J |
0.795 |
|
| 2013 |
Salazar B, Brandt DS, Coffman MD, Osterberg JR, Chantranuvatana K, Falke JJ, Knight J. Probing the Structural Origins of Unusually Strong Target Membrane Affinity of Synaptotagmin 7 C2A and C2Ab Domains Biophysical Journal. 104: 537a. DOI: 10.1016/J.Bpj.2012.11.2972 |
0.812 |
|
| 2012 |
Slivka PF, Falke JJ. Isolated bacterial chemosensory array possesses quasi- and ultrastable components: functional links between array stability, cooperativity, and order. Biochemistry. 51: 10218-28. PMID 23186266 DOI: 10.1021/Bi301287H |
0.784 |
|
| 2012 |
Brandt DS, Coffman MD, Falke JJ, Knight JD. Hydrophobic contributions to the membrane docking of synaptotagmin 7 C2A domain: mechanistic contrast between isoforms 1 and 7. Biochemistry. 51: 7654-64. PMID 22966849 DOI: 10.1021/Bi3007115 |
0.786 |
|
| 2012 |
Chen HC, Ziemba BP, Landgraf KE, Corbin JA, Falke JJ. Membrane docking geometry of GRP1 PH domain bound to a target lipid bilayer: an EPR site-directed spin-labeling and relaxation study. Plos One. 7: e33640. PMID 22479423 DOI: 10.1371/Journal.Pone.0033640 |
0.821 |
|
| 2012 |
Falke JJ. Lipid targeting domain with dual-membrane specificity that expands the diversity of intracellular targeting reactions. Proceedings of the National Academy of Sciences of the United States of America. 109: 1816-7. PMID 22308463 DOI: 10.1073/Pnas.1120856109 |
0.458 |
|
| 2012 |
Ziemba BP, Knight JD, Falke JJ. Assembly of membrane-bound protein complexes: detection and analysis by single molecule diffusion. Biochemistry. 51: 1638-47. PMID 22263647 DOI: 10.1021/Bi201743A |
0.8 |
|
| 2012 |
Ziemba BP, Knight JD, Falke JJ. Analysis of Protein Complex Formation on Membrane Surfaces by Single Molecule Diffusion Biophysical Journal. 102: 183a. DOI: 10.1016/J.Bpj.2011.11.994 |
0.794 |
|
| 2012 |
Brandt DS, Coffman M, Falke JJ, Knight J. Synaptotagmin C2 Domain Membrane Targeting: Kinetic and Mechanistic Diversity Among Isoforms from Different Cell Types Biophysical Journal. 102: 433a. DOI: 10.1016/J.Bpj.2011.11.2372 |
0.812 |
|
| 2011 |
Pilling C, Landgraf KE, Falke JJ. The GRP1 PH domain, like the AKT1 PH domain, possesses a sentry glutamate residue essential for specific targeting to plasma membrane PI(3,4,5)P(3). Biochemistry. 50: 9845-56. PMID 21932773 DOI: 10.1021/Bi2011306 |
0.799 |
|
| 2011 |
Bornhorst BJ, Falke JJ. Reprint of: Purification of Proteins Using Polyhistidine Affinity Tags. Protein Expression and Purification. PMID 21893196 DOI: 10.1016/J.Pep.2011.08.022 |
0.325 |
|
| 2011 |
Erbse AH, Berlinberg AJ, Cheung CY, Leung WY, Falke JJ. OS-FRET: a new one-sample method for improved FRET measurements. Biochemistry. 50: 451-7. PMID 21110513 DOI: 10.1021/Bi101188B |
0.733 |
|
| 2011 |
Chen H, Falke JJ. Understanding the Membrane Docking Geometry of GRP1 PH Domain Using Site-Directed Spin-Labeling and EPR Biophysical Journal. 100. DOI: 10.1016/J.Bpj.2010.12.998 |
0.45 |
|
| 2011 |
Chase AR, Knight JD, Falke JJ. Protein-Lipid Interactions Shaping the Electrostatic Membrane Search of a Pleckstrin Homology Domain Biophysical Journal. 100: 525a. DOI: 10.1016/J.Bpj.2010.12.3070 |
0.805 |
|
| 2011 |
Erbse AH, Berlinberg AJ, Falke JJ. Conformational Changes during Kinase On-Off Switching in the Chemosensory Signaling Array of the Bacterial Cell Membrane: Detection by One-Sample FRET Biophysical Journal. 100: 417a. DOI: 10.1016/J.Bpj.2010.12.2471 |
0.8 |
|
| 2010 |
Knight JD, Lerner MG, Marcano-Velázquez JG, Pastor RW, Falke JJ. Single molecule diffusion of membrane-bound proteins: window into lipid contacts and bilayer dynamics. Biophysical Journal. 99: 2879-87. PMID 21044585 DOI: 10.1016/J.Bpj.2010.08.046 |
0.791 |
|
| 2010 |
Lai CL, Landgraf KE, Voth GA, Falke JJ. Membrane docking geometry and target lipid stoichiometry of membrane-bound PKCα C2 domain: a combined molecular dynamics and experimental study. Journal of Molecular Biology. 402: 301-10. PMID 20659476 DOI: 10.1016/J.Jmb.2010.07.037 |
0.826 |
|
| 2010 |
Hutchinson MR, Loram LC, Zhang Y, Shridhar M, Rezvani N, Berkelhammer D, Phipps S, Foster PS, Landgraf K, Falke JJ, Rice KC, Maier SF, Yin H, Watkins LR. Evidence that tricyclic small molecules may possess toll-like receptor and myeloid differentiation protein 2 activity. Neuroscience. 168: 551-63. PMID 20381591 DOI: 10.1016/J.Neuroscience.2010.03.067 |
0.757 |
|
| 2010 |
Hutchinson MR, Zhang Y, Shridhar M, Evans JH, Buchanan MM, Zhao TX, Slivka PF, Coats BD, Rezvani N, Wieseler J, Hughes TS, Landgraf KE, Chan S, Fong S, Phipps S, ... Falke JJ, et al. Evidence that opioids may have toll-like receptor 4 and MD-2 effects. Brain, Behavior, and Immunity. 24: 83-95. PMID 19679181 DOI: 10.1016/J.Bbi.2009.08.004 |
0.756 |
|
| 2010 |
Knight J, Falke JJ. Membrane Diffusion of PH Domain-PIP3 Complexes: the Effects of Target Lipid Stoichiometry on Diffusion Constant Probed Using Single-Molecule Fluorescence Microscopy Biophysical Journal. 98: 86a. DOI: 10.1016/J.Bpj.2009.12.489 |
0.792 |
|
| 2010 |
Falke JJ. Second Messengers at the Leading Edge: Calcium Joins PIP3 as an Essential Signal Biophysical Journal. 98. DOI: 10.1016/J.Bpj.2009.12.3389 |
0.413 |
|
| 2010 |
Owens ZJ, Landgraf KE, Corbin JA, Dukellis DC, Falke JJ. Structural Analysis of the Membrane Docking Geometry of PI(3,4,5)P3-Specific GRP1-PH Domain Via Site-Directed Spin Labeling Biophysical Journal. 98: 400a-401a. DOI: 10.1016/J.Bpj.2009.12.2159 |
0.824 |
|
| 2009 |
Falke JJ, Erbse AH. The piston rises again. Structure (London, England : 1993). 17: 1149-51. PMID 19748334 DOI: 10.1016/J.Str.2009.08.005 |
0.771 |
|
| 2009 |
Swain KE, Gonzalez MA, Falke JJ. Engineered socket study of signaling through a four-helix bundle: evidence for a yin-yang mechanism in the kinase control module of the aspartate receptor. Biochemistry. 48: 9266-77. PMID 19705835 DOI: 10.1021/Bi901020D |
0.444 |
|
| 2009 |
Erbse AH, Falke JJ. The core signaling proteins of bacterial chemotaxis assemble to form an ultrastable complex. Biochemistry. 48: 6975-87. PMID 19456111 DOI: 10.1021/Bi900641C |
0.783 |
|
| 2009 |
Gloor SL, Falke JJ. Thermal domain motions of CheA kinase in solution: Disulfide trapping reveals the motional constraints leading to trans-autophosphorylation. Biochemistry. 48: 3631-44. PMID 19256549 DOI: 10.1021/Bi900033R |
0.398 |
|
| 2009 |
Knight JD, Falke JJ. Single-molecule fluorescence studies of a PH domain: new insights into the membrane docking reaction. Biophysical Journal. 96: 566-82. PMID 19167305 DOI: 10.1016/J.Bpj.2008.10.020 |
0.803 |
|
| 2009 |
Knight J, Falke JJ. Single Molecule Fluorescence Studies of Membrane Targeting Proteins: Lateral Diffusion in Supported Bilayers Reveals Additional Lipid Binding Sites Biophysical Journal. 96: 207a. DOI: 10.1016/J.Bpj.2008.12.1842 |
0.797 |
|
| 2008 |
Landgraf KE, Pilling C, Falke JJ. Molecular mechanism of an oncogenic mutation that alters membrane targeting: Glu17Lys modifies the PIP lipid specificity of the AKT1 PH domain. Biochemistry. 47: 12260-9. PMID 18954143 DOI: 10.1021/Bi801683K |
0.81 |
|
| 2008 |
Landgraf KE, Malmberg NJ, Falke JJ. Effect of PIP2 binding on the membrane docking geometry of PKC alpha C2 domain: an EPR site-directed spin-labeling and relaxation study. Biochemistry. 47: 8301-16. PMID 18610985 DOI: 10.1021/Bi800711T |
0.832 |
|
| 2008 |
Hazelbauer GL, Falke JJ, Parkinson JS. Bacterial chemoreceptors: high-performance signaling in networked arrays. Trends in Biochemical Sciences. 33: 9-19. PMID 18165013 DOI: 10.1016/J.Tibs.2007.09.014 |
0.34 |
|
| 2007 |
Falke JJ. Membrane Recruitment as a Cancer Mechanism: A Case Study of Akt PH Domain. Cellscience. 4: 25-30. PMID 19079757 |
0.302 |
|
| 2007 |
Swain KE, Falke JJ. Structure of the conserved HAMP domain in an intact, membrane-bound chemoreceptor: a disulfide mapping study. Biochemistry. 46: 13684-95. PMID 17994770 DOI: 10.1021/Bi701832B |
0.48 |
|
| 2007 |
Evans JH, Falke JJ. Ca2+ influx is an essential component of the positive-feedback loop that maintains leading-edge structure and activity in macrophages. Proceedings of the National Academy of Sciences of the United States of America. 104: 16176-81. PMID 17911247 DOI: 10.1073/Pnas.0707719104 |
0.362 |
|
| 2007 |
Endres RG, Falke JJ, Wingreen NS. Chemotaxis receptor complexes: from signaling to assembly. Plos Computational Biology. 3: e150. PMID 17676982 DOI: 10.1371/Journal.Pcbi.0030150 |
0.402 |
|
| 2007 |
Bass RB, Butler SL, Chervitz SA, Gloor SL, Falke JJ. Use of site-directed cysteine and disulfide chemistry to probe protein structure and dynamics: applications to soluble and transmembrane receptors of bacterial chemotaxis. Methods in Enzymology. 423: 25-51. PMID 17609126 DOI: 10.1016/S0076-6879(07)23002-2 |
0.804 |
|
| 2007 |
Bass RB, Miller AS, Gloor SL, Falke JJ. The PICM chemical scanning method for identifying domain-domain and protein-protein interfaces: applications to the core signaling complex of E. coli chemotaxis. Methods in Enzymology. 423: 3-24. PMID 17609125 DOI: 10.1016/S0076-6879(07)23001-0 |
0.824 |
|
| 2007 |
Corbin JA, Evans JH, Landgraf KE, Falke JJ. Mechanism of specific membrane targeting by C2 domains: localized pools of target lipids enhance Ca2+ affinity. Biochemistry. 46: 4322-36. PMID 17367165 DOI: 10.1021/Bi062140C |
0.826 |
|
| 2007 |
Jaud S, Tobias DJ, Falke JJ, White SH. Self-induced docking site of a deeply embedded peripheral membrane protein. Biophysical Journal. 92: 517-24. PMID 17071664 DOI: 10.1529/Biophysj.106.090704 |
0.46 |
|
| 2006 |
Miller AS, Kohout SC, Gilman KA, Falke JJ. CheA Kinase of bacterial chemotaxis: chemical mapping of four essential docking sites. Biochemistry. 45: 8699-711. PMID 16846213 DOI: 10.1021/Bi060580Y |
0.815 |
|
| 2006 |
Evans JH, Murray D, Leslie CC, Falke JJ. Specific translocation of protein kinase Calpha to the plasma membrane requires both Ca2+ and PIP2 recognition by its C2 domain. Molecular Biology of the Cell. 17: 56-66. PMID 16236797 DOI: 10.1091/Mbc.E05-06-0499 |
0.49 |
|
| 2005 |
Winston SE, Mehan R, Falke JJ. Evidence that the adaptation region of the aspartate receptor is a dynamic four-helix bundle: cysteine and disulfide scanning studies. Biochemistry. 44: 12655-66. PMID 16171380 DOI: 10.1021/Bi0507884 |
0.461 |
|
| 2005 |
Coleman MD, Bass RB, Mehan RS, Falke JJ. Conserved glycine residues in the cytoplasmic domain of the aspartate receptor play essential roles in kinase coupling and on-off switching. Biochemistry. 44: 7687-95. PMID 15909983 DOI: 10.1021/Bi0501479 |
0.794 |
|
| 2005 |
Malmberg NJ, Falke JJ. Use of EPR power saturation to analyze the membrane-docking geometries of peripheral proteins: applications to C2 domains. Annual Review of Biophysics and Biomolecular Structure. 34: 71-90. PMID 15869384 DOI: 10.1146/Annurev.Biophys.34.040204.144534 |
0.813 |
|
| 2005 |
Starrett DJ, Falke JJ. Adaptation mechanism of the aspartate receptor: electrostatics of the adaptation subdomain play a key role in modulating kinase activity. Biochemistry. 44: 1550-60. PMID 15683239 DOI: 10.1021/Bi048089Z |
0.416 |
|
| 2004 |
Malmberg NJ, Varma S, Jakobsson E, Falke JJ. Ca2+ activation of the cPLA2 C2 domain: ordered binding of two Ca2+ ions with positive cooperativity. Biochemistry. 43: 16320-8. PMID 15610026 DOI: 10.1021/Bi0482405 |
0.786 |
|
| 2004 |
Corbin JA, Dirkx RA, Falke JJ. GRP1 pleckstrin homology domain: activation parameters and novel search mechanism for rare target lipid. Biochemistry. 43: 16161-73. PMID 15610010 DOI: 10.1021/Bi049017A |
0.805 |
|
| 2004 |
Miller AF, Falke JJ. Chemotaxis receptors and signaling. Advances in Protein Chemistry. 68: 393-444. PMID 15500867 DOI: 10.1016/S0065-3233(04)68011-9 |
0.581 |
|
| 2004 |
Miller AS, Falke JJ. Side chains at the membrane-water interface modulate the signaling state of a transmembrane receptor. Biochemistry. 43: 1763-70. PMID 14967017 DOI: 10.1021/Bi0360206 |
0.602 |
|
| 2003 |
Malmberg NJ, Van Buskirk DR, Falke JJ. Membrane-docking loops of the cPLA2 C2 domain: detailed structural analysis of the protein-membrane interface via site-directed spin-labeling. Biochemistry. 42: 13227-40. PMID 14609334 DOI: 10.1021/Bi035119+ |
0.823 |
|
| 2003 |
Mehan RS, White NC, Falke JJ. Mapping out regions on the surface of the aspartate receptor that are essential for kinase activation. Biochemistry. 42: 2952-9. PMID 12627961 DOI: 10.1021/Bi027127G |
0.446 |
|
| 2003 |
Bornhorst JA, Falke JJ. Quantitative analysis of aspartate receptor signaling complex reveals that the homogeneous two-state model is inadequate: development of a heterogeneous two-state model. Journal of Molecular Biology. 326: 1597-614. PMID 12595268 DOI: 10.1016/S0022-2836(03)00026-3 |
0.678 |
|
| 2003 |
Kohout SC, Corbalán-García S, Gómez-Fernández JC, Falke JJ. C2 domain of protein kinase C alpha: elucidation of the membrane docking surface by site-directed fluorescence and spin labeling. Biochemistry. 42: 1254-65. PMID 12564928 DOI: 10.1021/Bi026596F |
0.797 |
|
| 2002 |
Kohout SC, Corbalán-García S, Torrecillas A, Goméz-Fernandéz JC, Falke JJ. C2 domains of protein kinase C isoforms alpha, beta, and gamma: activation parameters and calcium stoichiometries of the membrane-bound state. Biochemistry. 41: 11411-24. PMID 12234184 DOI: 10.1021/Bi026041K |
0.789 |
|
| 2002 |
Falke JJ. Cooperativity between bacterial chemotaxis receptors. Proceedings of the National Academy of Sciences of the United States of America. 99: 6530-2. PMID 12011417 DOI: 10.1073/Pnas.112214199 |
0.382 |
|
| 2002 |
Frazier AA, Wisner MA, Malmberg NJ, Victor KG, Fanucci GE, Nalefski EA, Falke JJ, Cafiso DS. Membrane orientation and position of the C2 domain from cPLA2 by site-directed spin labeling. Biochemistry. 41: 6282-92. PMID 12009889 DOI: 10.1021/Bi0160821 |
0.829 |
|
| 2002 |
Falke JJ. Enzymology. A moving story. Science (New York, N.Y.). 295: 1480-1. PMID 11859184 DOI: 10.1126/Science.1069823 |
0.343 |
|
| 2002 |
Nalefski EA, Falke JJ. Use of fluorescence resonance energy transfer to monitor Ca(2+)-triggered membrane docking of C2 domains. Methods in Molecular Biology (Clifton, N.J.). 172: 295-303. PMID 11833355 DOI: 10.1385/1-59259-183-3:295 |
0.771 |
|
| 2002 |
Nalefski EA, Falke JJ. Cation charge and size selectivity of the C2 domain of cytosolic phospholipase A(2). Biochemistry. 41: 1109-22. PMID 11802709 DOI: 10.1021/Bi011798H |
0.798 |
|
| 2001 |
Bornhorst JA, Falke JJ. Evidence that both ligand binding and covalent adaptation drive a two-state equilibrium in the aspartate receptor signaling complex. The Journal of General Physiology. 118: 693-710. PMID 11723162 DOI: 10.1085/Jgp.118.6.693 |
0.716 |
|
| 2001 |
Falke JJ, Hazelbauer GL. Transmembrane signaling in bacterial chemoreceptors. Trends in Biochemical Sciences. 26: 257-65. PMID 11295559 DOI: 10.1016/S0968-0004(00)01770-9 |
0.46 |
|
| 2001 |
Nalefski EA, Wisner MA, Chen JZ, Sprang SR, Fukuda M, Mikoshiba K, Falke JJ. C2 domains from different Ca2+ signaling pathways display functional and mechanistic diversity. Biochemistry. 40: 3089-100. PMID 11258923 DOI: 10.1021/Bi001968A |
0.798 |
|
| 2000 |
Bornhorst JA, Falke JJ. Purification of proteins using polyhistidine affinity tags. Methods in Enzymology. 326: 245-54. PMID 11036646 DOI: 10.1016/S0076-6879(00)26058-8 |
0.668 |
|
| 2000 |
Falke JJ, Kim SH. Structure of a conserved receptor domain that regulates kinase activity: the cytoplasmic domain of bacterial taxis receptors. Current Opinion in Structural Biology. 10: 462-9. PMID 10981636 DOI: 10.1016/S0959-440X(00)00115-9 |
0.469 |
|
| 2000 |
Bornhorst JA, Falke JJ. Attractant regulation of the aspartate receptor-kinase complex: limited cooperative interactions between receptors and effects of the receptor modification state. Biochemistry. 39: 9486-93. PMID 10924144 DOI: 10.1021/Bi0002737 |
0.689 |
|
| 1999 |
Bass RB, Falke JJ. The aspartate receptor cytoplasmic domain: in situ chemical analysis of structure, mechanism and dynamics. Structure (London, England : 1993). 7: 829-40. PMID 10425684 DOI: 10.1016/S0969-2126(99)80106-3 |
0.799 |
|
| 1999 |
Bass RB, Coleman MD, Falke JJ. Signaling domain of the aspartate receptor is a helical hairpin with a localized kinase docking surface: cysteine and disulfide scanning studies. Biochemistry. 38: 9317-27. PMID 10413506 DOI: 10.1021/Bi9908179 |
0.785 |
|
| 1999 |
Trammell MA, Falke JJ. Identification of a site critical for kinase regulation on the central processing unit (CPU) helix of the aspartate receptor. Biochemistry. 38: 329-36. PMID 9890914 DOI: 10.1021/Bi981964U |
0.409 |
|
| 1998 |
Nalefski EA, Falke JJ. Location of the membrane-docking face on the Ca2+-activated C2 domain of cytosolic phospholipase A2. Biochemistry. 37: 17642-50. PMID 9922129 DOI: 10.1021/Bi982372E |
0.803 |
|
| 1998 |
Hazard AL, Kohout SC, Stricker NL, Putkey JA, Falke JJ. The kinetic cycle of cardiac troponin C: calcium binding and dissociation at site II trigger slow conformational rearrangements. Protein Science : a Publication of the Protein Society. 7: 2451-9. PMID 9828012 DOI: 10.1002/Pro.5560071123 |
0.751 |
|
| 1998 |
Bass RB, Falke JJ. Detection of a conserved alpha-helix in the kinase-docking region of the aspartate receptor by cysteine and disulfide scanning. The Journal of Biological Chemistry. 273: 25006-14. PMID 9737956 DOI: 10.1074/Jbc.273.39.25006 |
0.792 |
|
| 1998 |
Butler SL, Falke JJ. Cysteine and disulfide scanning reveals two amphiphilic helices in the linker region of the aspartate chemoreceptor. Biochemistry. 37: 10746-56. PMID 9692965 DOI: 10.1021/Bi980607G |
0.709 |
|
| 1998 |
Nalefski EA, McDonagh T, Somers W, Seehra J, Falke JJ, Clark JD. Independent folding and ligand specificity of the C2 calcium-dependent lipid binding domain of cytosolic phospholipase A2. The Journal of Biological Chemistry. 273: 1365-72. PMID 9430670 DOI: 10.1074/Jbc.273.3.1365 |
0.798 |
|
| 1997 |
Falke JJ, Bass RB, Butler SL, Chervitz SA, Danielson MA. The two-component signaling pathway of bacterial chemotaxis: a molecular view of signal transduction by receptors, kinases, and adaptation enzymes. Annual Review of Cell and Developmental Biology. 13: 457-512. PMID 9442881 DOI: 10.1146/Annurev.Cellbio.13.1.457 |
0.8 |
|
| 1997 |
Danielson MA, Bass RB, Falke JJ. Cysteine and disulfide scanning reveals a regulatory alpha-helix in the cytoplasmic domain of the aspartate receptor. The Journal of Biological Chemistry. 272: 32878-88. PMID 9407066 DOI: 10.1074/Jbc.272.52.32878 |
0.802 |
|
| 1997 |
Nalefski EA, Slazas MM, Falke JJ. Ca2+-signaling cycle of a membrane-docking C2 domain. Biochemistry. 36: 12011-8. PMID 9340010 DOI: 10.1021/Bi9717340 |
0.805 |
|
| 1997 |
Drake SK, Zimmer MA, Miller CL, Falke JJ. Optimizing the metal binding parameters of an EF-hand-like calcium chelation loop: coordinating side chains play a more important tuning role than chelation loop flexibility. Biochemistry. 36: 9917-26. PMID 9245425 DOI: 10.1021/Bi9703913 |
0.792 |
|
| 1997 |
Drake SK, Zimmer MA, Kundrot C, Falke JJ. Molecular tuning of an EF-hand-like calcium binding loop. Contributions of the coordinating side chain at loop position 3. The Journal of General Physiology. 110: 173-84. PMID 9236210 DOI: 10.1085/Jgp.110.2.173 |
0.793 |
|
| 1997 |
Peersen OB, Madsen TS, Falke JJ. Intermolecular tuning of calmodulin by target peptides and proteins: differential effects on Ca2+ binding and implications for kinase activation. Protein Science : a Publication of the Protein Society. 6: 794-807. PMID 9098889 DOI: 10.1002/Pro.5560060406 |
0.704 |
|
| 1996 |
Nalefski EA, Falke JJ. The C2 domain calcium-binding motif: structural and functional diversity. Protein Science : a Publication of the Protein Society. 5: 2375-90. PMID 8976547 DOI: 10.1002/Pro.5560051201 |
0.802 |
|
| 1996 |
Danielson MA, Falke JJ. Use of 19F NMR to probe protein structure and conformational changes. Annual Review of Biophysics and Biomolecular Structure. 25: 163-95. PMID 8800468 DOI: 10.1146/Annurev.Bb.25.060196.001115 |
0.357 |
|
| 1996 |
Butler SL, Falke JJ. Effects of protein stabilizing agents on thermal backbone motions: a disulfide trapping study. Biochemistry. 35: 10595-600. PMID 8718847 DOI: 10.1021/Bi961107V |
0.662 |
|
| 1996 |
Drake SK, Falke JJ. Kinetic tuning of the EF-hand calcium binding motif: the gateway residue independently adjusts (i) barrier height and (ii) equilibrium. Biochemistry. 35: 1753-60. PMID 8639655 DOI: 10.1021/Bi952335C |
0.782 |
|
| 1996 |
Drake SK, Lee KL, Falke JJ. Tuning the equilibrium ion affinity and selectivity of the EF-hand calcium binding motif: substitutions at the gateway position. Biochemistry. 35: 6697-705. PMID 8639620 DOI: 10.1021/Bi952430L |
0.788 |
|
| 1996 |
Chervitz SA, Falke JJ. Molecular mechanism of transmembrane signaling by the aspartate receptor: a model. Proceedings of the National Academy of Sciences of the United States of America. 93: 2545-50. PMID 8637911 DOI: 10.1073/Pnas.93.6.2545 |
0.796 |
|
| 1995 |
Falke JJ, Blair DF, Silhavy TJ, Schmitt R. BLAST 1995: international conference on bacterial locomotion and signal transduction. Molecular Microbiology. 16: 1037-50. PMID 8577240 DOI: 10.1111/J.1365-2958.1995.Tb02329.X |
0.301 |
|
| 1995 |
Careaga CL, Sutherland J, Sabeti J, Falke JJ. Large amplitude twisting motions of an interdomain hinge: a disulfide trapping study of the galactose-glucose binding protein. Biochemistry. 34: 3048-55. PMID 7893717 DOI: 10.1021/Bi00009A036 |
0.799 |
|
| 1995 |
Chervitz SA, Lin CM, Falke JJ. Transmembrane signaling by the aspartate receptor: engineered disulfides reveal static regions of the subunit interface. Biochemistry. 34: 9722-33. PMID 7626643 DOI: 10.1021/Bi00030A010 |
0.805 |
|
| 1995 |
Chervitz SA, Falke JJ. Lock on/off disulfides identify the transmembrane signaling helix of the aspartate receptor. The Journal of Biological Chemistry. 270: 24043-53. PMID 7592603 DOI: 10.1074/Jbc.270.41.24043 |
0.813 |
|
| 1994 |
Danielson MA, Biemann HP, Koshland DE, Falke JJ. Attractant- and disulfide-induced conformational changes in the ligand binding domain of the chemotaxis aspartate receptor: A19F NMR study Biochemistry. 33: 6100-6109. PMID 7910759 DOI: 10.1021/Bi00186A009 |
0.562 |
|
| 1994 |
Falke JJ, Drake SK, Hazard AL, Peersen OB. Molecular tuning of ion binding to calcium signaling proteins. Quarterly Reviews of Biophysics. 27: 219-90. PMID 7899550 DOI: 10.1017/S0033583500003012 |
0.767 |
|
| 1993 |
Bourret RB, Drake SK, Chervitz SA, Simon MI, Falke JJ. Activation of the phosphosignaling protein CheY: II. Analysis of activated mutants by 19F NMR and protein engineering Journal of Biological Chemistry. 268: 13089-13096. PMID 8514750 |
0.788 |
|
| 1993 |
Drake SK, Bourret RB, Lucke LA, Simon MI, Falke JJ. Activation of the phosphosignaling protein CheY: I. Analysis of the phosphorylated conformation by 19F NMR and protein engineering Journal of Biological Chemistry. 268: 13081-13088. PMID 8514749 |
0.78 |
|
| 1993 |
Needham JV, Chen TY, Falke JJ. Novel ion specificity of a carboxylate cluster Mg(II) binding site: strong charge selectivity and weak size selectivity. Biochemistry. 32: 3363-7. PMID 8461299 DOI: 10.1021/Bi00064A020 |
0.339 |
|
| 1993 |
Renner M, Danielson MA, Falke JJ. Kinetic control of Ca(II) signaling: Tuning the ion dissociation rates of EF-hand Ca(II) binding sites Proceedings of the National Academy of Sciences of the United States of America. 90: 6493-6497. PMID 8341660 DOI: 10.1073/Pnas.90.14.6493 |
0.378 |
|
| 1992 |
Careaga CL, Falke JJ. Thermal motions of surface alpha-helices in the D-galactose chemosensory receptor. Detection by disulfide trapping. Journal of Molecular Biology. 226: 1219-35. PMID 1518053 DOI: 10.1016/0022-2836(92)91063-U |
0.798 |
|
| 1992 |
Falke JJ, Luck LA, Scherrer J. F nuclear magnetic resonance studies of aqueous and transmembrane receptors: Examples from the Escherichia coli chemosensory pathway Biophysical Journal. 62: 82-86. PMID 1318106 DOI: 10.1016/S0006-3495(92)81787-3 |
0.696 |
|
| 1992 |
Careaga CL, Falke JJ. Structure and dynamics of Escherichia coli chemosensory receptors. Engineered sulfhydryl studies. Biophysical Journal. 62: 209-16; discussion 2. PMID 1318100 DOI: 10.1016/S0006-3495(92)81806-4 |
0.79 |
|
| 1991 |
Luck LA, Falke JJ. 19F NMR studies of the D-galactose chemosensory receptor. 2. Ca(II) binding yields a local structural change. Biochemistry. 30: 4257-61. PMID 1850620 |
0.683 |
|
| 1991 |
Luck LA, Falke JJ. 19F NMR studies of the D-galactose chemosensory receptor. 1. Sugar binding yields a global structural change. Biochemistry. 30: 4248-56. PMID 1850619 DOI: 10.1021/Bi00231A021 |
0.739 |
|
| 1991 |
Falke JJ, Snyder EE, Thatcher KC, Voertler CS. Quantitating and engineering the ion specificity of an EF-hand-like Ca2+ binding. Biochemistry. 30: 8690-7. PMID 1653605 DOI: 10.1021/Bi00099A029 |
0.394 |
|
| 1991 |
Luck LA, Falke JJ. Open conformation of a substrate-binding cleft: 19F NMR studies of cleft angle in the D-galactose chemosensory receptor. Biochemistry. 30: 6484-90. PMID 1647202 DOI: 10.1021/Bi00240A019 |
0.699 |
|
| 1990 |
Snyder EE, Buoscio BW, Falke JJ. Calcium(II) Site Specificity: Effect of Size and Charge on Metal Ion Binding to an EF-Hand-like Site Biochemistry. 29: 3937-3943. PMID 2162201 DOI: 10.1021/Bi00468A021 |
0.367 |
|
| 1987 |
Falke JJ, Koshland DE. Global flexibility in a sensory receptor: a site-directed cross-linking approach. Science (New York, N.Y.). 237: 1596-600. PMID 2820061 DOI: 10.1126/Science.2820061 |
0.557 |
|
| 1986 |
Falke JJ, Chan SI. Molecular mechanisms of band 3 inhibitors. 3. Translocation inhibitors. Biochemistry. 25: 7899-906. PMID 3801448 DOI: 10.1021/Bi00372A017 |
0.5 |
|
| 1986 |
Falke JJ, Chan SI. Molecular mechanisms of band 3 inhibitors. 2. Channel blockers. Biochemistry. 25: 7895-8. PMID 3801447 DOI: 10.1021/Bi00372A016 |
0.499 |
|
| 1986 |
Falke JJ, Chan SI. Molecular mechanisms of band 3 inhibitors. 1. Transport site inhibitors. Biochemistry. 25: 7888-94. PMID 3801446 DOI: 10.1021/Bi00372A015 |
0.502 |
|
| 1986 |
Wang JF, Falke JJ, Chan SI. A proton NMR study of the mechanism of the erythrocyte glucose transporter. Proceedings of the National Academy of Sciences of the United States of America. 83: 3277-81. PMID 3458182 DOI: 10.1073/Pnas.83.10.3277 |
0.505 |
|
| 1985 |
Falke JJ, Kanes KJ, Chan SI. The minimal structure containing the band 3 anion transport site. A 35Cl NMR study. The Journal of Biological Chemistry. 260: 13294-303. PMID 4055737 |
0.471 |
|
| 1985 |
Falke JJ, Kanes KJ, Chan SI. The kinetic equation for the chloride transport cycle of band 3. A 35Cl and 37Cl NMR study. The Journal of Biological Chemistry. 260: 9545-51. PMID 4019485 |
0.468 |
|
| 1985 |
Falke JJ, Chan SI. Evidence that anion transport by band 3 proceeds via a ping-pong mechanism involving a single transport site. A 35 Cl NMR study. The Journal of Biological Chemistry. 260: 9537-44. PMID 4019484 |
0.447 |
|
| 1984 |
Falke JJ, Chan SI. Ion Channels within Ion Transport Proteins: Evidence in the Band 3 System. Biophysical Journal. 45: 91-2. PMID 19431579 DOI: 10.1016/S0006-3495(84)84120-X |
0.452 |
|
| 1984 |
Falke JJ, Pace RJ, Chan SI. Direct observation of the transmembrane recruitment of band 3 transport sites by competitive inhibitors. A 35Cl NMR study. The Journal of Biological Chemistry. 259: 6481-91. PMID 6725261 |
0.454 |
|
| 1984 |
Falke JJ, Pace RJ, Chan SI. Chloride binding to the anion transport binding sites of band 3. A 35Cl NMR study. The Journal of Biological Chemistry. 259: 6472-80. PMID 6725260 |
0.45 |
|
| 1984 |
Falke JJ, Chan SI, Steiner M, Oesterhelt D, Towner P, Lanyi JK. Halide binding by the purified halorhodopsin chromoprotein. II. New chloride-binding sites revealed by 35Cl NMR. The Journal of Biological Chemistry. 259: 2185-9. PMID 6698962 |
0.474 |
|
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