Donald M. Bers, Ph.D. - Publications

Affiliations: 
Pharmacology University of California, Davis, Davis, CA 

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Year Citation  Score
2024 Wang Y, Zhao M, Liu X, Xu B, Reddy GR, Jovanovic A, Wang Q, Zhu C, Xu H, Bayne EF, Xiang W, Tilley DG, Ge Y, Tate CG, Feil R, ... ... Bers DM, et al. Carvedilol Activates a Myofilament Signaling Circuitry to Restore Cardiac Contractility in Heart Failure. Jacc. Basic to Translational Science. 9: 982-1001. PMID 39297139 DOI: 10.1016/j.jacbts.2024.03.007  0.34
2024 Bers DM. Cardiac Ca current is 'Rad'-ically altered by adrenergic activation. Nature Cardiovascular Research. 1: 980-981. PMID 39195913 DOI: 10.1038/s44161-022-00163-0  0.475
2024 Bers DM. Cardiac Na-Ca exchanger "tunes-out" at high intracellular [Na]. Cell Calcium. 123: 102930. PMID 39067331 DOI: 10.1016/j.ceca.2024.102930  0.469
2024 Rebbeck RT, Svensson B, Zhang J, Samsó M, Thomas DD, Bers DM, Cornea RL. Kinetics and mapping of Ca-driven calmodulin conformations on skeletal and cardiac muscle ryanodine receptors. Nature Communications. 15: 5120. PMID 38879623 DOI: 10.1038/s41467-024-48951-5  0.399
2024 Bround MJ, Abay E, Huo J, Havens JR, York AJ, Bers DM, Molkentin JD. MCU-independent Ca uptake mediates mitochondrial Ca overload and necrotic cell death in a mouse model of Duchenne muscular dystrophy. Scientific Reports. 14: 6751. PMID 38514795 DOI: 10.1038/s41598-024-57340-3  0.399
2023 Huo J, Prasad V, Grimes KM, Vanhoutte D, Blair NS, Lin SC, Bround MJ, Bers DM, Molkentin JD. MCUb is an inducible regulator of calcium-dependent mitochondrial metabolism and substrate utilization in muscle. Cell Reports. 42: 113465. PMID 37976157 DOI: 10.1016/j.celrep.2023.113465  0.3
2023 Power AS, Asamudo EU, Worthington LPI, Alim CC, Parackal RE, Wallace RS, Ebenebe OV, Heller Brown J, Kohr MJ, Bers DM, Erickson JR. Nitric Oxide Modulates Ca Leak and Arrhythmias via S-Nitrosylation of CaMKII. Circulation Research. PMID 37961889 DOI: 10.1161/CIRCRESAHA.123.323571  0.451
2023 Power AS, Asamudo E, Worthington LPI, Alim CC, Parackal R, Wallace RS, Ebenebe OV, Heller Brown J, Kohr MJ, Bers DM, Erickson JR. Nitric Oxide modulates spontaneous Ca release and ventricular arrhythmias during β-adrenergic signalling through -nitrosylation of Calcium/Calmodulin dependent kinase II. Biorxiv : the Preprint Server For Biology. PMID 37662205 DOI: 10.1101/2023.08.23.554546  0.429
2023 Svensson B, Nitu FR, Rebbeck RT, McGurran LM, Oda T, Thomas DD, Bers DM, Cornea RL. Molecular Mechanism of a FRET Biosensor for the Cardiac Ryanodine Receptor Pathologically Leaky State. International Journal of Molecular Sciences. 24. PMID 37628726 DOI: 10.3390/ijms241612547  0.379
2023 Tomek J, Nieves-Cintron M, Navedo MF, Ko CY, Bers DM. SparkMaster 2: A New Software for Automatic Analysis of Calcium Spark Data. Circulation Research. PMID 37555352 DOI: 10.1161/CIRCRESAHA.123.322847  0.451
2023 Svensson B, Nitu FR, Rebbeck RT, McGurran LM, Oda T, Thomas DD, Bers DM, Cornea RL. Molecular Mechanism of a FRET Biosensor for the Cardiac Ryanodine Receptor Pathologically Leaky State. Biorxiv : the Preprint Server For Biology. PMID 37461514 DOI: 10.1101/2023.07.07.548138  0.404
2023 Hernandez JM, Ko CY, Mandel AR, Shen EY, Baidar S, Christensen AR, Hellgren K, Morotti S, Martin JL, Hegyi B, Bossuyt J, Bers DM. Cardiac protein kinase D1 ablation alters the myocytes β-adrenergic response. Journal of Molecular and Cellular Cardiology. PMID 37149124 DOI: 10.1016/j.yjmcc.2023.05.001  0.514
2023 Chen-Izu Y, Jian Z, Hegyi B, Shimkunas R, Kazemi-Lari MA, Gabriel M, Sato D, Chiamvimonvat N, Bers DM, Lam KS, Shaw JA, Izu LT. Autoregulation of excitation-Ca signaling-contraction and arrhythmogenesisin cardiomyocyte under mechanical load. Biophysical Journal. 122: 375a-376a. PMID 36783908 DOI: 10.1016/j.bpj.2022.11.2066  0.371
2023 Grandi E, Navedo MF, Saucerman JJ, Bers DM, Chiamvimonvat N, Dixon RE, Dobrev D, Gomez AM, Harraz OF, Hegyi B, Jones DK, Krogh-Madsen T, Murfee WL, Nystoriak MA, Posnack NG, et al. Diversity of Cells and Signals in the Cardiovascular System. The Journal of Physiology. PMID 36744541 DOI: 10.1113/JP284011  0.552
2022 Hegyi B, Mira Hernandez J, Ko CY, Hong J, Shen EY, Spencer ER, Smoliarchuk D, Navedo MF, Bers DM, Bossuyt J. Diabetes and Excess Aldosterone Promote Heart Failure With Preserved Ejection Fraction. Journal of the American Heart Association. e027164. PMID 36416174 DOI: 10.1161/JAHA.122.027164  0.311
2022 Martín-Aragón Baudel M, Flores-Tamez VA, Hong J, Reddy GR, Maillard P, Burns AE, Man KNM, Sasse KC, Ward SM, Catterall WA, Bers DM, Hell JW, Nieves-Cintrón M, Navedo MF. Spatiotemporal Control of Vascular Ca1.2 by α1 S1928 Phosphorylation. Circulation Research. PMID 36345826 DOI: 10.1161/CIRCRESAHA.122.321479  0.42
2022 Alim CC, Ko CY, Mira Hernandez J, Shen EY, Baidar S, Chen-Izu Y, Bers DM, Bossuyt J. Nitrosylation of cardiac CaMKII at Cys290 mediates mechanical afterload-induced increases in Ca transient and Ca sparks. The Journal of Physiology. PMID 36227145 DOI: 10.1113/JP283427  0.525
2022 Voglhuber J, Holzer M, Radulović S, Thai PN, Djalinac N, Matzer I, Wallner M, Bugger H, Zirlik A, Leitinger G, Dedkova EN, Bers DM, Ljubojevic-Holzer S. Functional remodelling of perinuclear mitochondria alters nucleoplasmic Ca signalling in heart failure. Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences. 377: 20210320. PMID 36189813 DOI: 10.1098/rstb.2021.0320  0.449
2022 Shannon TR, Bare DJ, Van Dijk S, Raofi S, Huynh TN, Xiang YK, Bossuyt J, Dodge-Kafka KL, Ginsburg KS, Bers DM. Subcellular Propagation of Cardiomyocyte β-Adrenergic Activation of Calcium Uptake Involves Internal β-Receptors and AKAP7. Function (Oxford, England). 3: zqac020. PMID 35620477 DOI: 10.1093/function/zqac020  0.363
2022 Rebbeck R, Ginsburg KS, Ko CY, Fasoli A, Rusch K, Cai GF, Dong X, Thomas DD, Bers DM, Cornea RL. Synergistic FRET assays for drug discovery targeting RyR2 channels. Journal of Molecular and Cellular Cardiology. 168: 13-23. PMID 35405106 DOI: 10.1016/j.yjmcc.2022.04.002  0.303
2021 Zhang J, Singh DP, Ko CY, Nikolaienko R, Wong King Yuen SM, Schwarz JA, Treinen LM, Tung CC, Rožman K, Svensson B, Aldrich CC, Zima AV, Thomas DD, Bers DM, Launikonis BS, et al. Cardiac ryanodine receptor N-terminal region biosensors identify novel inhibitors via FRET-based high-throughput screening. The Journal of Biological Chemistry. 101412. PMID 34793835 DOI: 10.1016/j.jbc.2021.101412  0.362
2021 Hegyi B, Pölönen RP, Hellgren KT, Ko CY, Ginsburg KS, Bossuyt J, Mercola M, Bers DM. Cardiomyocyte Na and Ca mishandling drives vicious cycle involving CaMKII, ROS, and ryanodine receptors. Basic Research in Cardiology. 116: 58. PMID 34648073 DOI: 10.1007/s00395-021-00900-9  0.444
2021 Bers DM, Nattel S. Cardiac Na/Ca Exchange Suppression: A Late-Breaking Knockout Story Showing That There Is No Free Lunch. Journal of the American Heart Association. e022512. PMID 34472381 DOI: 10.1161/JAHA.121.022512  0.494
2021 Simon M, Ko CY, Rebbeck RT, Baidar S, Cornea RL, Bers DM. CaMKIIδ post-translational modifications increase affinity for calmodulin inside cardiac ventricular myocytes. Journal of Molecular and Cellular Cardiology. PMID 34371035 DOI: 10.1016/j.yjmcc.2021.08.002  0.493
2021 Hegyi B, Shimkunas R, Jian Z, Izu LT, Bers DM, Chen-Izu Y. Mechanoelectric coupling and arrhythmogenesis in cardiomyocytes contracting under mechanical afterload in a 3D viscoelastic hydrogel. Proceedings of the National Academy of Sciences of the United States of America. 118. PMID 34326268 DOI: 10.1073/pnas.2108484118  0.503
2021 Wang L, Myles RC, Lee IJ, Bers DM, Ripplinger CM. Role of Reduced Sarco-Endoplasmic Reticulum Ca-ATPase Function on Sarcoplasmic Reticulum Ca Alternans in the Intact Rabbit Heart. Frontiers in Physiology. 12: 656516. PMID 34045974 DOI: 10.3389/fphys.2021.656516  0.485
2021 Sato D, Uchinoumi H, Bers DM. Increasing SERCA function promotes initiation of calcium sparks and breakup of calcium waves. The Journal of Physiology. PMID 33963531 DOI: 10.1113/JP281579  0.376
2021 Hegyi B, Fasoli A, Ko CY, Van BW, Alim CC, Shen EY, Ciccozzi MM, Tapa S, Ripplinger CM, Erickson J, Bossuyt J, Bers DM. CaMKII Serine 280 O-GlcNAcylation Links Diabetic Hyperglycemia to Proarrhythmia. Circulation Research. PMID 33926209 DOI: 10.1161/CIRCRESAHA.120.318402  0.317
2021 Shimkunas R, Hegyi B, Jian Z, Shaw JA, Kazemi-Lari MA, Mitra D, Leach K, Li X, Jaradeh M, Balardi N, Chen YJ, Escobar AL, Baker AJ, Bossuyt J, Banyasz T, ... ... Bers DM, et al. Mechanical Load Regulates Excitation-Ca Signaling-Contraction in Cardiomyocyte. Circulation Research. PMID 33601939 DOI: 10.1161/CIRCRESAHA.120.318570  0.374
2021 Mustroph J, Sag CM, Bähr F, Schmidtmann AL, Gupta SN, Dietz A, Islam MT, Lücht CM, Beuthner BE, Pabel S, Baier MJ, El-Armouche A, Sossalla S, Anderson ME, Möllmann J, ... ... Bers DM, et al. Loss of CASK Accelerates Heart Failure Development. Circulation Research. PMID 33593074 DOI: 10.1161/CIRCRESAHA.120.318170  0.449
2021 Helmstadter KG, Ljubojevic-Holzer S, Wood BM, Taheri KD, Sedej S, Erickson JR, Bossuyt J, Bers DM. CaMKII and PKA-dependent phosphorylation co-regulate nuclear localization of HDAC4 in adult cardiomyocytes. Basic Research in Cardiology. 116: 11. PMID 33590335 DOI: 10.1007/s00395-021-00850-2  0.8
2020 Turner M, Anderson DE, Bartels P, Nieves-Cintron M, Coleman AM, Henderson PB, Man KNM, Tseng PY, Yarov-Yarovoy V, Bers DM, Navedo MF, Horne MC, Ames JB, Hell JW. α-Actinin-1 promotes activity of the L-type Ca channel Ca1.2. The Embo Journal. 39: e106171. PMID 33433005 DOI: 10.15252/embj.2020106171  0.409
2020 Qi XY, Vahdahi Hassani F, Hoffmann D, Xiao J, Xiong F, Villeneuve LR, Ljubojevic-Holzer S, Kamler M, Abu-Taha I, Heijman J, Bers DM, Dobrev D, Nattel S. Inositol Trisphosphate Receptors and Nuclear Calcium in Atrial Fibrillation. Circulation Research. PMID 33375812 DOI: 10.1161/CIRCRESAHA.120.317768  0.464
2020 Yan J, Bare DJ, DeSantiago J, Zhao W, Mei Y, Chen Z, Ginsburg KS, Solaro RJ, Wolska BM, Bers DM, Chen SW, Ai X. JNK2, A Newly-Identified SERCA2 Enhancer, Augments an Arrhythmic [Ca] Leak-Load Relationship. Circulation Research. PMID 33334123 DOI: 10.1161/CIRCRESAHA.120.318409  0.508
2020 Ljubojevic-Holzer S, Herren AW, Djalinac N, Voglhuber J, Morotti S, Holzer M, Wood BM, Abdellatif M, Matzer I, Sacherer M, Radulovic S, Wallner M, Ivanov M, Wagner S, Sossalla S, ... ... Bers DM, et al. CaMKIIδC Drives Early Adaptive Ca Change and Late Eccentric Cardiac Hypertrophy. Circulation Research. PMID 32821022 DOI: 10.1161/Circresaha.120.316947  0.557
2020 Feyen DAM, McKeithan WL, Bruyneel AAN, Spiering S, Hörmann L, Ulmer B, Zhang H, Briganti F, Schweizer M, Hegyi B, Liao Z, Pölönen RP, Ginsburg KS, Lam CK, Serrano R, ... ... Bers DM, et al. Metabolic Maturation Media Improve Physiological Function of Human iPSC-Derived Cardiomyocytes. Cell Reports. 32: 107925. PMID 32697997 DOI: 10.1016/J.Celrep.2020.107925  0.384
2020 Huo J, Lu S, Kwong JQ, Bround MJ, Grimes KM, Sargent MA, Brown ME, Davis ME, Bers DM, Molkentin JD. MCUb Induction Protects the Heart from Post-Ischemic Remodeling. Circulation Research. PMID 32299299 DOI: 10.1161/Circresaha.119.316369  0.474
2020 Hegyi B, Chen-Izu Y, Izu LT, Rajamani S, Belardinelli L, Bers DM, Bányász T. Balance Between Rapid Delayed Rectifier K Current and Late Na Current on Ventricular Repolarization: An Effective Antiarrhythmic Target? Circulation. Arrhythmia and Electrophysiology. PMID 32202931 DOI: 10.1161/Circep.119.008130  0.403
2020 Lu S, Liao Z, Lu X, Katschinski DM, Mercola M, Chen J, Heller Brown J, Molkentin JD, Bossuyt J, Bers DM. Hyperglycemia Acutely Increases Cytosolic Reactive Oxygen Species via -linked GlcNAcylation and CaMKII Activation in Mouse Ventricular Myocytes. Circulation Research. PMID 32134364 DOI: 10.1161/Circresaha.119.316288  0.403
2020 Rebbeck RT, Singh DP, Janicek KA, Bers DM, Thomas DD, Launikonis BS, Cornea RL. RyR1-targeted drug discovery pipeline integrating FRET-based high-throughput screening and human myofiber dynamic Ca assays. Scientific Reports. 10: 1791. PMID 32019969 DOI: 10.1038/S41598-020-58461-1  0.486
2020 Bers DM, Kohl P, Chen-Izu Y. Special issue: Mechanics and energetics in cardiac arrhythmias and heart failure. The Journal of Physiology. PMID 31998965 DOI: 10.1113/Jp279385  0.351
2020 Turner M, Anderson DE, Bartels P, Nieves-Cintron M, Coleman AM, Henderson PB, Man KNM, Tseng PY, Yarov-Yarovoy V, Bers DM, Navedo MF, Horne MC, Ames JB, Hell JW. α-Actinin-1 promotes activity of the L-type Ca channel Ca 1.2. The Embo Journal. e102622. PMID 31985069 DOI: 10.15252/Embj.2019102622  0.514
2020 Grandi E, Ni H, Iseppe AF, Ghayoumi B, Wang L, Jiang Y, Chen Y, Bers DM, Sato D, Edwards AG, Ripplinger CM, Morotti S. SPARC: Found in translation: quantitative predictors of cardiac myocyte responses to β‐adrenergic stimulation across species The Faseb Journal. 34: 1-1. DOI: 10.1096/Fasebj.2020.34.S1.06511  0.305
2020 Thai P, Herren AW, Ren L, Bers DM, Schaefer S, Dedkova EN. Mitochondrial Translocator Protein (TSPO) Prevents Heart Failure by Increasing Cardiac Utilization of Fatty Acids Biophysical Journal. 118: 445a-446a. DOI: 10.1016/J.Bpj.2019.11.2492  0.328
2019 Izu LT, Kohl P, Boyden PA, Miura M, Banyasz T, Chiamvimonvat N, Trayanova N, Bers DM, Chen-Izu Y. Mechano-electric and mechano-chemo-transduction in cardiomyocytes. The Journal of Physiology. PMID 31789427 DOI: 10.1113/Jp276494  0.435
2019 Tiscione SA, Vivas O, Ginsburg KS, Bers DM, Ory DS, Santana LF, Dixon RE, Dickson EJ. Disease-associated mutations in Niemann-Pick type C1 alter ER calcium signaling and neuronal plasticity. The Journal of Cell Biology. PMID 31601621 DOI: 10.1083/Jcb.201903018  0.5
2019 Lu X, Thai PN, Lu S, Pu J, Bers DM. Intrafibrillar and perinuclear mitochondrial heterogeneity in adult cardiac myocytes. Journal of Molecular and Cellular Cardiology. PMID 31491377 DOI: 10.1016/J.Yjmcc.2019.08.013  0.373
2019 Wang L, Morotti S, Tapa S, Francis Stuart SD, Jiang Y, Wang Z, Myles RC, Brack KE, Ng GA, Bers DM, Grandi E, Ripplinger CM. Different paths, same destination: divergent action potential responses produce conserved cardiac fight-or-flight response in mouse and rabbit hearts. The Journal of Physiology. PMID 31215643 DOI: 10.1113/Jp278016  0.484
2019 Bers DM, Xiang YK, Zaccolo M. Whole-Cell cAMP and PKA Activity are Epiphenomena, Nanodomain Signaling Matters. Physiology (Bethesda, Md.). 34: 240-249. PMID 31165682 DOI: 10.1152/Physiol.00002.2019  0.346
2019 Thai PN, Seidlmayer LK, Miller C, Ferrero M, Dorn Ii GW, Schaefer S, Bers DM, Dedkova EN. Mitochondrial Quality Control in Aging and Heart Failure: Influence of Ketone Bodies and Mitofusin-Stabilizing Peptides. Frontiers in Physiology. 10: 382. PMID 31024341 DOI: 10.3389/Fphys.2019.00382  0.304
2019 Hegyi B, Morotti S, Liu C, Ginsburg KS, Bossuyt J, Belardinelli L, Izu LT, Chen-Izu Y, Bányász T, Grandi E, Bers DM. Enhanced Depolarization Drive in Failing Rabbit Ventricular Myocytes. Circulation. Arrhythmia and Electrophysiology. 12: e007061. PMID 30879336 DOI: 10.1161/Circep.118.007061  0.541
2019 Pereira CLV, Ximenes CF, Merlo E, Sciortino AS, Monteiro JS, Moreira A, Jacobsen BB, Graceli JB, Ginsburg KS, Ribeiro Junior RF, Bers DM, Stefanon I. Cardiotoxicity of environmental contaminant tributyltin involves myocyte oxidative stress and abnormal Ca handling. Environmental Pollution (Barking, Essex : 1987). 247: 371-382. PMID 30690233 DOI: 10.1016/J.Envpol.2019.01.053  0.586
2019 Xie Y, Yang Y, Galice S, Bers DM, Sato D. Size Matters: Ryanodine Receptor Cluster Size Heterogeneity Potentiates Calcium Waves. Biophysical Journal. PMID 30686487 DOI: 10.1016/J.Bpj.2018.12.017  0.489
2019 Hegyi B, Bers DM, Bossuyt J. CaMKII signaling in heart diseases: Emerging role in diabetic cardiomyopathy. Journal of Molecular and Cellular Cardiology. 127: 246-259. PMID 30633874 DOI: 10.1016/J.Yjmcc.2019.01.001  0.418
2019 Hegyi B, Borst JM, Lucena AJ, Bailey LR, Bossuyt J, Bers DM. Diabetic Hyperglycemia Regulates Potassium Channels and Arrhythmias in the Heart via Autonomous CaMKII Activation by O-Linked Glycosylation Biophysical Journal. 116: 98a. DOI: 10.1016/J.Bpj.2018.11.566  0.302
2019 Liu C, Hegyi B, Ni H, Bers DM, Grandi E, Morotti S. Quantitative In Silico Analysis of the Arrhythmogenic CaMKII-Sodium-Calcium-CaMKII Feedback in the Failing Rabbit Ventricular Myocyte Biophysical Journal. 116: 94a-95a. DOI: 10.1016/J.Bpj.2018.11.552  0.306
2018 Seidlmayer LK, Gomez-Garcia MR, Shiba T, Porter GA, Pavlov EV, Bers DM, Dedkova EN. Dual role of inorganic polyphosphate in cardiac myocytes: The importance of polyP chain length for energy metabolism and mPTP activation. Archives of Biochemistry and Biophysics. 662: 177-189. PMID 30571965 DOI: 10.1016/J.Abb.2018.12.019  0.333
2018 Kwong JQ, Huo J, Bround MJ, Boyer JG, Schwanekamp JA, Ghazal N, Maxwell JT, Jang YC, Khuchua Z, Shi K, Bers DM, Davis J, Molkentin JD. The mitochondrial calcium uniporter underlies metabolic fuel preference in skeletal muscle. Jci Insight. 3. PMID 30429366 DOI: 10.1172/Jci.Insight.121689  0.416
2018 Thai PN, Daugherty DJ, Frederich BJ, Lu X, Deng W, Bers DM, Dedkova EN, Schaefer S. Cardiac-specific Conditional Knockout of the 18-kDa Mitochondrial Translocator Protein Protects from Pressure Overload Induced Heart Failure. Scientific Reports. 8: 16213. PMID 30385779 DOI: 10.1038/S41598-018-34451-2  0.444
2018 Oda T, Yamamoto T, Kato T, Uchinoumi H, Fukui G, Hamada Y, Nanno T, Ishiguchi H, Nakamura Y, Okamoto Y, Kono M, Okuda S, Kobayashi S, Bers DM, Yano M. Nuclear translocation of calmodulin in pathological cardiac hypertrophy originates from ryanodine receptor bound calmodulin. Journal of Molecular and Cellular Cardiology. PMID 30359562 DOI: 10.1016/J.Yjmcc.2018.10.011  0.401
2018 Wood BM, Simon M, Galice S, Alim CC, Ferrero M, Pinna NN, Bers DM, Bossuyt J. Cardiac CaMKII activation promotes rapid translocation to its extra-dyadic targets. Journal of Molecular and Cellular Cardiology. PMID 30321537 DOI: 10.1016/J.Yjmcc.2018.10.010  0.559
2018 Morra EA, Rodrigues PL, Guedes de Jesus IC, Do Val Lima PR, Ávila RA, Zanardo TÉC, Nogueira BV, Bers DM, Guatimosim S, Stefanon I, Ribeiro Júnior RF. Endurance training restores spatially distinct cardiac mitochondrial function and myocardial contractility in ovariectomized rats. Free Radical Biology & Medicine. PMID 30315935 DOI: 10.1016/J.Freeradbiomed.2018.10.406  0.339
2018 Hegyi B, Bányász T, Izu LT, Belardinelli L, Bers DM, Chen-Izu Y. β-adrenergic regulation of late Na current during cardiac action potential is mediated by both PKA and CaMKII. Journal of Molecular and Cellular Cardiology. PMID 30240676 DOI: 10.1016/J.Yjmcc.2018.09.006  0.425
2018 Galice S, Xie Y, Yang Y, Sato D, Bers DM. Size Matters: Ryanodine Receptor Cluster Size Affects Arrhythmogenic Sarcoplasmic Reticulum Calcium Release. Journal of the American Heart Association. 7. PMID 29929992 DOI: 10.1161/Jaha.118.008724  0.46
2018 Hegyi B, Bossuyt J, Griffiths LG, Shimkunas R, Coulibaly Z, Jian Z, Grimsrud KN, Sondergaard CS, Ginsburg KS, Chiamvimonvat N, Belardinelli L, Varró A, Papp JG, Pollesello P, Levijoki J, ... ... Bers DM, et al. Complex electrophysiological remodeling in postinfarction ischemic heart failure. Proceedings of the National Academy of Sciences of the United States of America. PMID 29531045 DOI: 10.1073/Pnas.1718211115  0.449
2018 Hegyi B, Bossuyt J, Ginsburg KS, Mendoza LM, Talken L, Ferrier WT, Pogwizd SM, Izu LT, Chen-Izu Y, Bers DM. Altered Repolarization Reserve in Failing Rabbit Ventricular Myocytes: Calcium and β-Adrenergic Effects on Delayed- and Inward-Rectifier Potassium Currents. Circulation. Arrhythmia and Electrophysiology. 11: e005852. PMID 29437761 DOI: 10.1161/Circep.117.005852  0.378
2018 Yan J, Zhao W, Thomson JK, Gao X, DeMarco DM, Carrillo E, Chen B, Wu X, Ginsburg KS, Bakhos M, Bers DM, Anderson ME, Song LS, Fill M, Ai X. Stress Signaling JNK2 Crosstalk with CaMKII Underlies Enhanced Atrial Arrhythmogenesis. Circulation Research. PMID 29352041 DOI: 10.1161/Circresaha.117.312536  0.514
2018 Samia el Hayek M, Bers D, Gomez A, Pereira L. Role of Epac2 in High Glucose-Induced SR Ca2+ Leak and Arrhythmia Biophysical Journal. 114: 618a. DOI: 10.1016/J.Bpj.2017.11.3345  0.47
2018 Stefanon I, Vieira Pereira CL, Barcellos Jacobsen B, Ribeiro Junior RF, Bers DM. Tributytin Induces Negative Inotropic Effect, Reduces Cardiac SR Calcium Content and Increases Calcium Sparks Frequency in Cardiomyocytes Biophysical Journal. 114: 501a. DOI: 10.1016/J.Bpj.2017.11.2740  0.33
2018 Samia El Hayek M, Bers D, Gomez A, Pereira L. Role of Epac2 in high glucose induced SR Ca 2+ leak and arrhythmia Archives of Cardiovascular Diseases Supplements. 10: 244. DOI: 10.1016/j.acvdsp.2018.02.148  0.365
2017 Liu M, Hoskins A, Verma N, Bers DM, Despa S, Despa F. Amylin and diabetic cardiomyopathy - amylin-induced sarcolemmal Ca(2+) leak is independent of diabetic remodeling of myocardium. Biochimica Et Biophysica Acta. PMID 29066284 DOI: 10.1016/J.Bbadis.2017.10.024  0.412
2017 Lang D, Sato D, Jiang Y, Ginsburg KS, Ripplinger CM, Bers DM. Calcium-Dependent Arrhythmogenic Foci Created by Weakly Coupled Myocytes in the Failing Heart. Circulation Research. PMID 28970285 DOI: 10.1161/Circresaha.117.312050  0.568
2017 Sato D, Clancy CE, Bers DM. Dynamics of sodium current mediated early afterdepolarizations. Heliyon. 3: e00388. PMID 28924617 DOI: 10.1016/J.Heliyon.2017.E00388  0.493
2017 Yuen GK, Galice S, Bers DM. Subcellular localization of Na/K-ATPase isoforms in ventricular myocytes. Journal of Molecular and Cellular Cardiology. PMID 28587810 DOI: 10.1016/J.Yjmcc.2017.05.013  0.302
2017 Pereira L, Bare DJ, Galice S, Shannon TR, Bers DM. 0β-Adrenergic induced SR Ca(2+) leak is mediated by an Epac-NOS pathway. Journal of Molecular and Cellular Cardiology. PMID 28476660 DOI: 10.1016/J.Yjmcc.2017.04.005  0.564
2017 Surdo NC, Berrera M, Koschinski A, Brescia M, Machado MR, Carr C, Wright P, Gorelik J, Morotti S, Grandi E, Bers DM, Pantano S, Zaccolo M. FRET biosensor uncovers cAMP nano-domains at β-adrenergic targets that dictate precise tuning of cardiac contractility. Nature Communications. 8: 15031. PMID 28425435 DOI: 10.1038/Ncomms15031  0.367
2017 Bers DM, Chen-Izu Y. K(+) channels and cardiac electrophysiology. The Journal of Physiology. 595: 2205-2207. PMID 28370016 DOI: 10.1113/Jp274181  0.324
2017 Bers DM. CALMing Down Arrhythmogenic Calmodulinopathies via a Precision Medicine Approach. Circulation Research. 120: 3-4. PMID 28057778 DOI: 10.1161/Circresaha.116.310216  0.547
2017 Rebbeck RT, Ryan MV, Gillispie GD, Thomas DD, Bers DM, Cornea RL. High-Throughput Screens to Discover Inhibitors of Leaky Ryanodine Receptor Calcium Channels Biophysical Journal. 112: 483a. DOI: 10.1016/J.Bpj.2016.11.2616  0.499
2017 Hegyi B, Bossuyt J, Griffiths LG, Shimkunas R, Coulibaly Z, Ginsburg KS, Izu LT, Bányász T, Bers DM, Chen-Izu Y. Ionic Current Changes during Action Potentials in Porcine Post-MI Heart Failure Model Biophysical Journal. 112: 402a. DOI: 10.1016/J.Bpj.2016.11.2178  0.348
2017 Liao Z, Ginsburg KS, Bartos DC, Jiang Y, Despa S, Bers DM. High Diastolic Sodium Influx in Heart Failure has Drug-Sensitivities Like Late Sodium Current, but Produces Inward Current at Diastolic Potentials Biophysical Journal. 112: 333a. DOI: 10.1016/J.Bpj.2016.11.1802  0.469
2017 Thai PN, Daugherty D, Frederich BJ, Galice S, Deng W, Bers DM, Schaefer S, Dedkova EN. Emerging Role of the Mitochondrial Outer Membrane Translocator Protein (TSPO) in Heart Failure and Mitochondrai Quality Control Biophysical Journal. 112: 325a. DOI: 10.1016/J.Bpj.2016.11.1758  0.32
2017 Dong X, Stefanon I, Ribeiro RF, Said M, Rebbeck RT, Cornea RL, Bers DM. Mg 2+ Inhibits Cardiac SR Calcium Release and has Biphasic Effects on Calmodulin Binding to RyR2 Biophysical Journal. 112: 255a. DOI: 10.1016/J.Bpj.2016.11.1390  0.489
2017 Rebbeck RT, Svensson B, Haskin CE, Samso M, Bers DM, Thomas DD, Cornea RL. FRET Based Mapping of Calmodulin within the Ryanodine Receptor Biophysical Journal. 112: 231a. DOI: 10.1016/J.Bpj.2015.11.1465  0.529
2016 Bartos DC, Morotti S, Ginsburg KS, Grandi E, Bers DM. Quantitative analysis of the Ca(2+) -dependent regulation of delayed rectifier K(+) current IKs in rabbit ventricular myocytes. The Journal of Physiology. PMID 28008618 DOI: 10.1113/Jp273676  0.578
2016 Kennedy M, Bers DM, Chiamvimonvat N, Sato D. Dynamical effects of calcium-sensitive potassium currents on voltage and calcium alternans. The Journal of Physiology. PMID 27902841 DOI: 10.1113/Jp273626  0.54
2016 Grandi E, Sanguinetti MC, Bartos DC, Bers DM, Chen-Izu Y, Chiamvimonvat N, Colecraft HM, Delisle BP, Heijman J, Navedo MF, Noskov S, Proenza C, Vandenberg JI, Yarov-Yarovoy V. Potassium channels in the heart: structure, function and regulation. The Journal of Physiology. PMID 27861921 DOI: 10.1113/Jp272864  0.34
2016 Chiamvimonvat N, Chen-Izu Y, Clancy CE, Deschenes I, Dobrev D, Heijman J, Izu L, Qu Z, Ripplinger CM, Vandenberg JI, Weiss JN, Koren G, Banyasz T, Grandi E, Sanguinetti MC, ... Bers DM, et al. Potassium currents in the heart: Functional roles in repolarization, arrhythmia and therapeutics. The Journal of Physiology. PMID 27808412 DOI: 10.1113/Jp272883  0.536
2016 Rebbeck RT, Essawy MM, Nitu FR, Grant BD, Gillispie GD, Thomas DD, Bers DM, Cornea RL. High-Throughput Screens to Discover Small-Molecule Modulators of Ryanodine Receptor Calcium Release Channels. Journal of Biomolecular Screening. PMID 27760856 DOI: 10.1177/1087057116674312  0.441
2016 Bers DM. Stabilizing ryanodine receptor gating quiets arrhythmogenic events in human heart failure and atrial fibrillation. Heart Rhythm : the Official Journal of the Heart Rhythm Society. PMID 27725286 DOI: 10.1016/J.Hrthm.2016.10.005  0.318
2016 Himes RD, Smolin N, Kukol A, Bossuyt J, Bers DM, Robia SL. L30A mutation of phospholemman mimics effects of cardiac glycosides in isolated cardiomyocytes. Biochemistry. PMID 27718550 DOI: 10.1021/Acs.Biochem.6B00633  0.445
2016 Barbagallo F, Xu B, Reddy G, West T, Wang Q, Fu Q, Li M, Shi Q, Ginsburg K, Ferrier W, Isidori A, Naro F, Patel H, Bossuyt J, Bers D, et al. Genetically Encoded Biosensors Reveal PKA Hyperphosphorylation on the Myofilaments in Rabbit Heart Failure. Circulation Research. PMID 27576469 DOI: 10.1161/Circresaha.116.308964  0.344
2016 Galice S, Bers DM, Sato D. Stretch-Activated Current Can Promote or Suppress Cardiac Alternans Depending on Voltage-Calcium Interaction. Biophysical Journal. 110: 2671-7. PMID 27332125 DOI: 10.1016/J.Bpj.2016.05.026  0.553
2016 Uchinoumi H, Yang Y, Oda T, Li N, Alsina KM, Puglisi JL, Chen-Izu Y, Cornea RL, Wehrens XH, Bers DM. CaMKII-dependent phosphorylation of RyR2 promotes targetable pathological RyR2 conformational shift. Journal of Molecular and Cellular Cardiology. PMID 27318036 DOI: 10.1016/J.Yjmcc.2016.06.007  0.559
2016 Rebbeck RT, Nitu FR, Rohde D, Most P, Bers DM, Thomas DD, Cornea RL. S100A1 does not compete with calmodulin for ryanodine receptor binding but structurally alters the ryanodine receptor/calmodulin complex. The Journal of Biological Chemistry. PMID 27226555 DOI: 10.1074/Jbc.M115.713107  0.451
2016 Sato D, Shannon TR, Bers DM. Sarcoplasmic Reticulum Structure and Functional Properties that Promote Long-Lasting Calcium Sparks. Biophysical Journal. 110: 382-90. PMID 26789761 DOI: 10.1016/J.Bpj.2015.12.009  0.531
2016 Kennedy M, Bers DM, Chiamvimonvat N, Sato D. Modeling of the Small-Conductance Calcium-Activated Potassium Channel and Cardiac Alternans Biophysical Journal. 110: 106a. DOI: 10.1016/J.Bpj.2015.11.630  0.437
2016 Shimkunas R, Jian Z, Hegyi B, Shaw J, Chiamvimonvat N, Ginsburg K, Bossuyt J, Bers DM, Lam KS, Izu LT, Chen-Izu Y. Mechano-Chemo-Transduction in Rabbit Cardiomyocytes Mediated by no Signaling Biophysical Journal. 110: 600a. DOI: 10.1016/J.Bpj.2015.11.3202  0.496
2016 Uchinoumi H, Yang Y, Oda T, Puglisi JL, Chen-Izu Y, Cornea RL, Wehrens XH, Bers DM. CaMKII and Heart Failure Promote a Pathological Ryanodine Receptor Conformation that Reduces Calmodulin Binding and Enhances SR Ca2+ Leak Biophysical Journal. 110: 599a. DOI: 10.1016/J.Bpj.2015.11.3198  0.514
2016 Demirkhanyan L, Palmer IP, Boyd W, Sondergaard CS, Grimsrud K, Griffiths LG, Bossuyt J, Bers DM, Zakharian E, Dedkova EN. Formation of Polyphosphate-Poly-Beta-Hydroxybutyrate Granule-Like Complexes in Heart Failure Myocytes Biophysical Journal. 110: 310a-311a. DOI: 10.1016/J.Bpj.2015.11.1668  0.444
2016 Xiao L, Yang Y, Gurrola GB, Nitu FR, Luis Puglisi J, Zhang L, Cornea RL, Bers DM, Valdivia HH. Fluorescence-Labeled Imperacalcin Binds to Open RyR2 Channels in Mouse Ventricular Myocytes Biophysical Journal. 110: 268a-269a. DOI: 10.1016/J.Bpj.2015.11.1462  0.489
2015 Lu X, Kwong J, Molkentin JD, Bers DM. Individual Cardiac Mitochondria Undergo Rare Transient Permeability Transition Pore Openings. Circulation Research. PMID 26712344 DOI: 10.1161/Circresaha.115.308093  0.348
2015 Hoeker GS, Hanafy MA, Oster RA, Bers DM, Pogwizd SM. Reduced Arrhythmia Inducibility with Calcium/Calmodulin-Dependent Protein Kinase II Inhibition in Heart Failure Rabbits. Journal of Cardiovascular Pharmacology. PMID 26650851 DOI: 10.1097/Fjc.0000000000000343  0.371
2015 Bers DM. Adrenergic Fight-or-Flight: S-NO Falls on PKA Targets. Circulation Research. 117: 747-9. PMID 26450885 DOI: 10.1161/Circresaha.115.307397  0.557
2015 Xie Y, Liao Z, Grandi E, Shiferaw Y, Bers DM. Slow [Na]i Changes and Positive Feedback Between Membrane Potential and [Ca]i Underlie Intermittent Early Afterdepolarizations and Arrhythmias. Circulation. Arrhythmia and Electrophysiology. PMID 26407967 DOI: 10.1161/Circep.115.003085  0.514
2015 Quijada P, Hariharan N, Cubillo JD, Bala KM, Emathinger JM, Wang BJ, Ormachea L, Bers DM, Sussman MA, Poizat C. Nuclear Calcium/Calmodulin-Dependent Protein Kinase II Signaling Enhances Cardiac Progenitor Cell Survival and Cardiac Lineage Commitment. The Journal of Biological Chemistry. PMID 26324717 DOI: 10.1074/Jbc.M115.657775  0.465
2015 Erickson JR, Nichols CB, Uchinoumi H, Stein ML, Bossuyt J, Bers DM. S-Nitrosylation induces both autonomous activation and inhibition of calciumcalmodulin dependent protein kinase II delta. The Journal of Biological Chemistry. PMID 26316536 DOI: 10.1074/Jbc.M115.650234  0.525
2015 Morotti S, McCulloch AD, Bers DM, Edwards AG, Grandi E. Atrial-selective targeting of arrhythmogenic phase-3 early afterdepolarizations in human myocytes. Journal of Molecular and Cellular Cardiology. PMID 26241847 DOI: 10.1016/J.Yjmcc.2015.07.030  0.665
2015 Ping P, Gustafsson ÅB, Bers DM, Blatter LA, Cai H, Jahangir A, Kelly D, Muoio D, O'Rourke B, Rabinovitch P, Trayanova N, Van Eyk J, Weiss JN, Wong R, Schwartz Longacre L. Harnessing the Power of Integrated Mitochondrial Biology and Physiology: A Special Report on the NHLBI Mitochondria in Heart Diseases Initiative. Circulation Research. 117: 234-238. PMID 26185209 DOI: 10.1161/Circresaha.117.306693  0.464
2015 Kwong JQ, Lu X, Correll RN, Schwanekamp JA, Vagnozzi RJ, Sargent MA, York AJ, Zhang J, Bers DM, Molkentin JD. The Mitochondrial Calcium Uniporter Selectively Matches Metabolic Output to Acute Contractile Stress in the Heart. Cell Reports. PMID 26119742 DOI: 10.1016/J.Celrep.2015.06.002  0.507
2015 Oda T, Yang Y, Uchinoumi H, Thomas DD, Chen-Izu Y, Kato T, Yamamoto T, Yano M, Cornea RL, Bers DM. Oxidation of ryanodine receptor (RyR) and calmodulin enhance Ca release and pathologically alter, RyR structure and calmodulin affinity. Journal of Molecular and Cellular Cardiology. PMID 26092277 DOI: 10.1016/J.Yjmcc.2015.06.009  0.44
2015 Grimm M, Ling H, Willeford A, Pereira L, Gray CB, Erickson JR, Sarma S, Respress JL, Wehrens XH, Bers DM, Brown JH. CaMKIIδ mediates β-adrenergic effects on RyR2 phosphorylation and SR Ca(2+) leak and the pathophysiological response to chronic β-adrenergic stimulation. Journal of Molecular and Cellular Cardiology. 85: 282-291. PMID 26080362 DOI: 10.1016/J.Yjmcc.2015.06.007  0.455
2015 Wagner S, Maier LS, Bers DM. Role of sodium and calcium dysregulation in tachyarrhythmias in sudden cardiac death. Circulation Research. 116: 1956-70. PMID 26044250 DOI: 10.1161/Circresaha.116.304678  0.529
2015 Pereira L, Rehmann H, Lao DH, Erickson JR, Bossuyt J, Chen J, Bers DM. Novel Epac fluorescent ligand reveals distinct Epac1 vs. Epac2 distribution and function in cardiomyocytes. Proceedings of the National Academy of Sciences of the United States of America. 112: 3991-6. PMID 25829540 DOI: 10.1073/Pnas.1416163112  0.382
2015 Hammer KP, Ljubojevic S, Ripplinger CM, Pieske BM, Bers DM. Cardiac myocyte alternans in intact heart: Influence of cell-cell coupling and β-adrenergic stimulation. Journal of Molecular and Cellular Cardiology. 84: 1-9. PMID 25828762 DOI: 10.1016/J.Yjmcc.2015.03.012  0.541
2015 Herren AW, Weber DM, Rigor RR, Margulies KB, Phinney BS, Bers DM. CaMKII Phosphorylation of NaV1.5: Novel in Vitro Sites Identified by Mass Spectrometry and Reduced S516 Phosphorylation in Human Heart Failure. Journal of Proteome Research. 14: 2298-311. PMID 25815641 DOI: 10.1021/Acs.Jproteome.5B00107  0.412
2015 Myles RC, Wang L, Bers DM, Ripplinger CM. Decreased inward rectifying K+ current and increased ryanodine receptor sensitivity synergistically contribute to sustained focal arrhythmia in the intact rabbit heart. The Journal of Physiology. 593: 1479-93. PMID 25772297 DOI: 10.1113/Jphysiol.2014.279638  0.455
2015 Shattock MJ, Ottolia M, Bers DM, Blaustein MP, Boguslavskyi A, Bossuyt J, Bridge JH, Chen-Izu Y, Clancy CE, Edwards A, Goldhaber J, Kaplan J, Lingrel JB, Pavlovic D, Philipson K, et al. Na+/Ca2+ exchange and Na+/K+-ATPase in the heart. The Journal of Physiology. 593: 1361-82. PMID 25772291 DOI: 10.1113/Jphysiol.2014.282319  0.833
2015 Chen-Izu Y, Shaw RM, Pitt GS, Yarov-Yarovoy V, Sack JT, Abriel H, Aldrich RW, Belardinelli L, Cannell MB, Catterall WA, Chazin WJ, Chiamvimonvat N, Deschenes I, Grandi E, Hund TJ, ... ... Bers DM, et al. Na+ channel function, regulation, structure, trafficking and sequestration. The Journal of Physiology. 593: 1347-60. PMID 25772290 DOI: 10.1113/Jphysiol.2014.281428  0.348
2015 Clancy CE, Chen-Izu Y, Bers DM, Belardinelli L, Boyden PA, Csernoch L, Despa S, Fermini B, Hool LC, Izu L, Kass RS, Lederer WJ, Louch WE, Maack C, Matiazzi A, et al. Deranged sodium to sudden death. The Journal of Physiology. 593: 1331-45. PMID 25772289 DOI: 10.1113/Jphysiol.2014.281204  0.599
2015 Bers DM, Chen-Izu Y. Sodium and calcium regulation in cardiac myocytes: from molecules to heart failure and arrhythmia. The Journal of Physiology. 593: 1327-9. PMID 25772288 DOI: 10.1113/Jp270133  0.388
2015 Mattiazzi A, Bassani RA, Escobar AL, Palomeque J, Valverde CA, Vila Petroff M, Bers DM. Chasing cardiac physiology and pathology down the CaMKII cascade. American Journal of Physiology. Heart and Circulatory Physiology. 308: H1177-H1191. PMID 25747749 DOI: 10.1152/Ajpheart.00007.2015  0.588
2015 Negroni JA, Morotti S, Lascano EC, Gomes AV, Grandi E, Puglisi JL, Bers DM. β-adrenergic effects on cardiac myofilaments and contraction in an integrated rabbit ventricular myocyte model. Journal of Molecular and Cellular Cardiology. 81: 162-75. PMID 25724724 DOI: 10.1016/J.Yjmcc.2015.02.014  0.516
2015 Feng N, Huke S, Zhu G, Tocchetti CG, Shi S, Aiba T, Kaludercic N, Hoover DB, Beck SE, Mankowski JL, Tomaselli GF, Bers DM, Kass DA, Paolocci N. Constitutive BDNF/TrkB signaling is required for normal cardiac contraction and relaxation. Proceedings of the National Academy of Sciences of the United States of America. 112: 1880-5. PMID 25583515 DOI: 10.1016/J.Autneu.2015.07.413  0.447
2015 Awad S, Al-Haffar KM, Marashly Q, Quijada P, Kunhi M, Al-Yacoub N, Wade FS, Mohammed SF, Al-Dayel F, Sutherland G, Assiri A, Sussman M, Bers D, Al-Habeeb W, Poizat C. Control of histone H3 phosphorylation by CaMKIIδ in response to haemodynamic cardiac stress. The Journal of Pathology. 235: 606-18. PMID 25421395 DOI: 10.1002/Path.4489  0.379
2015 Ljubojevic S, Bers DM. Nuclear calcium in cardiac myocytes. Journal of Cardiovascular Pharmacology. 65: 211-7. PMID 25329749 DOI: 10.1097/Fjc.0000000000000174  0.561
2015 Bossuyt J, Bers DM. Assessing GPCR and G protein signaling to the nucleus in live cells using fluorescent biosensors. Methods in Molecular Biology (Clifton, N.J.). 1234: 149-59. PMID 25304355 DOI: 10.1007/978-1-4939-1755-6_13  0.338
2015 Ljubojevi? S, Bers DM. Measuring intranuclear and nuclear envelope [Ca(2+)] vs. cytosolic [Ca (2+)]. Methods in Molecular Biology (Clifton, N.J.). 1234: 135-47. PMID 25304354 DOI: 10.1007/978-1-4939-1755-6_12  0.547
2015 Morotti S, McCulloch AD, Bers DM, Edwards AG, Grandi E. Atrial-selective targeting of arrhythmogenic phase-3 early afterdepolarizations in human myocytes Journal of Molecular and Cellular Cardiology. DOI: 10.1016/j.yjmcc.2015.07.030  0.388
2015 Galice S, Bers DM, Sato D. Stretch Activated Channel Activation can Promote or Suppress Cardiac Alternans Biophysical Journal. 108: 106a. DOI: 10.1016/J.Bpj.2014.11.605  0.564
2015 Bartos DC, Morotti S, Ginsburg KS, Grandi E, Bers DM. Intracellular Calcium Alters IKs Amplitude and Kinetics in Rabbit Myocytes Biophysical Journal. 108: 275a. DOI: 10.1016/J.Bpj.2014.11.1509  0.559
2015 Uchinoumi H, Yang Y, Puglisi JL, Chen-Izu Y, Cornea RL, Wehrens XH, Bers DM. CaMKII-Dependent Phosphorylation of RyR2 Causes Domain Unzipping and Reduced Calmodulin Binding, But Dantrolene Reverses These Effects Biophysical Journal. 108: 269a-270a. DOI: 10.1016/J.Bpj.2014.11.1482  0.544
2015 Rebbeck RT, Nitu FR, Rohde D, Most P, Bers DM, Thomas DD, Cornea RL. FRET-Based RyR-Selective Detection Reveals No Significant Competition between CaM and S100A1 Binding to RyRs Biophysical Journal. 108: 264a. DOI: 10.1016/J.Bpj.2014.11.1458  0.335
2015 Sato D, Shannon TR, Bers DM. Reduced Ca Flux via Ryanodine Receptor Cluster Size or Unitary Current can both Promote Long-Lasting Ca Sparks Biophysical Journal. 108: 262a. DOI: 10.1016/J.Bpj.2014.11.1448  0.483
2015 Morotti S, McCulloch AD, Bers DM, Edwards AG, Grandi E. Ranolazine Prevents Phase-3 Early Afterdepolarizations in Human Atrial Myocytes by Inhibiting Na Current Non-Equilibrium Reactivation Biophysical Journal. 108: 195a-196a. DOI: 10.1016/J.Bpj.2014.11.1080  0.641
2014 Horvath B, Bers DM. The late sodium current in heart failure: pathophysiology and clinical relevance. Esc Heart Failure. 1: 26-40. PMID 28834665 DOI: 10.1002/Ehf2.12003  0.341
2014 Svensson B, Oda T, Nitu FR, Yang Y, Cornea I, Chen-Izu Y, Fessenden JD, Bers DM, Thomas DD, Cornea RL. FRET-based trilateration of probes bound within functional ryanodine receptors. Biophysical Journal. 107: 2037-48. PMID 25418089 DOI: 10.1016/J.Bpj.2014.09.029  0.375
2014 Edwards AG, Grandi E, Hake JE, Patel S, Li P, Miyamoto S, Omens JH, Heller Brown J, Bers DM, McCulloch AD. Nonequilibrium reactivation of Na+ current drives early afterdepolarizations in mouse ventricle. Circulation. Arrhythmia and Electrophysiology. 7: 1205-13. PMID 25236710 DOI: 10.1161/Circep.113.001666  0.674
2014 Sato D, Bartos DC, Ginsburg KS, Bers DM. Depolarization of cardiac membrane potential synchronizes calcium sparks and waves in tissue. Biophysical Journal. 107: 1313-7. PMID 25229139 DOI: 10.1016/J.Bpj.2014.07.053  0.535
2014 Grandi E, Edwards AG, Herren AW, Bers DM. CaMKII comes of age in cardiac health and disease. Frontiers in Pharmacology. 5: 154. PMID 25071573 DOI: 10.3389/Fphar.2014.00154  0.47
2014 Bers DM, Morotti S. Ca(2+) current facilitation is CaMKII-dependent and has arrhythmogenic consequences. Frontiers in Pharmacology. 5: 144. PMID 24987371 DOI: 10.3389/Fphar.2014.00144  0.609
2014 Ljubojevic S, Radulovic S, Leitinger G, Sedej S, Sacherer M, Holzer M, Winkler C, Pritz E, Mittler T, Schmidt A, Sereinigg M, Wakula P, Zissimopoulos S, Bisping E, Post H, ... ... Bers DM, et al. Early remodeling of perinuclear Ca2+ stores and nucleoplasmic Ca2+ signaling during the development of hypertrophy and heart failure. Circulation. 130: 244-55. PMID 24928680 DOI: 10.1161/Circulationaha.114.008927  0.595
2014 Despa S, Shui B, Bossuyt J, Lang D, Kotlikoff MI, Bers DM. Junctional cleft [Ca²⁺]i measurements using novel cleft-targeted Ca²⁺ sensors. Circulation Research. 115: 339-47. PMID 24871564 DOI: 10.1161/Circresaha.115.303582  0.555
2014 Xie Y, Izu LT, Bers DM, Sato D. Arrhythmogenic transient dynamics in cardiac myocytes. Biophysical Journal. 106: 1391-7. PMID 24655514 DOI: 10.1016/J.Bpj.2013.12.050  0.328
2014 Jian Z, Han H, Zhang T, Puglisi J, Izu LT, Shaw JA, Onofiok E, Erickson JR, Chen YJ, Horvath B, Shimkunas R, Xiao W, Li Y, Pan T, Chan J, ... ... Bers DM, et al. Mechanochemotransduction during cardiomyocyte contraction is mediated by localized nitric oxide signaling. Science Signaling. 7: ra27. PMID 24643800 DOI: 10.1126/Scisignal.2005046  0.584
2014 Xie Y, Grandi E, Bers DM, Sato D. How does β-adrenergic signalling affect the transitions from ventricular tachycardia to ventricular fibrillation? Europace : European Pacing, Arrhythmias, and Cardiac Electrophysiology : Journal of the Working Groups On Cardiac Pacing, Arrhythmias, and Cardiac Cellular Electrophysiology of the European Society of Cardiology. 16: 452-7. PMID 24569900 DOI: 10.1093/Europace/Eut412  0.353
2014 Wang L, Myles RC, De Jesus NM, Ohlendorf AK, Bers DM, Ripplinger CM. Optical mapping of sarcoplasmic reticulum Ca2+ in the intact heart: ryanodine receptor refractoriness during alternans and fibrillation. Circulation Research. 114: 1410-21. PMID 24568740 DOI: 10.1161/Circresaha.114.302505  0.579
2014 Hwang HS, Nitu FR, Yang Y, Walweel K, Pereira L, Johnson CN, Faggioni M, Chazin WJ, Laver D, George AL, Cornea RL, Bers DM, Knollmann BC. Divergent regulation of ryanodine receptor 2 calcium release channels by arrhythmogenic human calmodulin missense mutants. Circulation Research. 114: 1114-24. PMID 24563457 DOI: 10.1161/Circresaha.114.303391  0.517
2014 Curran J, Tang L, Roof SR, Velmurugan S, Millard A, Shonts S, Wang H, Santiago D, Ahmad U, Perryman M, Bers DM, Mohler PJ, Ziolo MT, Shannon TR. Nitric oxide-dependent activation of CaMKII increases diastolic sarcoplasmic reticulum calcium release in cardiac myocytes in response to adrenergic stimulation. Plos One. 9: e87495. PMID 24498331 DOI: 10.1371/Journal.Pone.0087495  0.495
2014 Puglisi JL, Goldspink PH, Gomes AV, Utter MS, Bers DM, Solaro RJ. Influence of a constitutive increase in myofilament Ca(2+)-sensitivity on Ca(2+)-fluxes and contraction of mouse heart ventricular myocytes. Archives of Biochemistry and Biophysics. 552: 50-9. PMID 24480308 DOI: 10.1016/J.Abb.2014.01.019  0.593
2014 Morotti S, Edwards AG, McCulloch AD, Bers DM, Grandi E. A novel computational model of mouse myocyte electrophysiology to assess the synergy between Na+ loading and CaMKII. The Journal of Physiology. 592: 1181-97. PMID 24421356 DOI: 10.1113/Jphysiol.2013.266676  0.713
2014 Nystoriak MA, Nieves-Cintrón M, Nygren PJ, Hinke SA, Nichols CB, Chen CY, Puglisi JL, Izu LT, Bers DM, Dell'acqua ML, Scott JD, Santana LF, Navedo MF. AKAP150 contributes to enhanced vascular tone by facilitating large-conductance Ca2+-activated K+ channel remodeling in hyperglycemia and diabetes mellitus. Circulation Research. 114: 607-15. PMID 24323672 DOI: 10.1161/Circresaha.114.302168  0.396
2014 Zhang DM, Chai Y, Erickson JR, Brown JH, Bers DM, Lin YF. Intracellular signalling mechanism responsible for modulation of sarcolemmal ATP-sensitive potassium channels by nitric oxide in ventricular cardiomyocytes. The Journal of Physiology. 592: 971-90. PMID 24277866 DOI: 10.1113/Jphysiol.2013.264697  0.385
2014 Bers DM. Cardiac sarcoplasmic reticulum calcium leak: basis and roles in cardiac dysfunction. Annual Review of Physiology. 76: 107-27. PMID 24245942 DOI: 10.1146/Annurev-Physiol-020911-153308  0.58
2014 Correll RN, Eder P, Burr AR, Despa S, Davis J, Bers DM, Molkentin JD. Overexpression of the Na+/K+ ATPase α2 but not α1 isoform attenuates pathological cardiac hypertrophy and remodeling. Circulation Research. 114: 249-56. PMID 24218169 DOI: 10.1161/Circresaha.114.302293  0.596
2014 Yang Y, Guo T, Oda T, Chakraborty A, Chen L, Uchinoumi H, Knowlton AA, Fruen BR, Cornea RL, Meissner G, Bers DM. Cardiac myocyte Z-line calmodulin is mainly RyR2-bound, and reduction is arrhythmogenic and occurs in heart failure. Circulation Research. 114: 295-306. PMID 24186966 DOI: 10.1161/Circresaha.114.302857  0.54
2014 Horvath B, Banyasz T, Jian Z, Ginsburg K, Bossuyt J, Izu L, Bers D, Belardinelli L, Chen-Izu Y. P119Changes of the late sodium current and the inward rectifier potassium current can contribute to generation of arrhythmias in heart failure Cardiovascular Research. 103: S21.1-S21. DOI: 10.1093/Cvr/Cvu082.60  0.348
2014 Liao Z, Bers DM. Diabetic Hyperglycemia Acutely Affects Action Potentials and Ionic Currents through CaMKII Activation on Rat Ventricular Myocytes Biophysical Journal. 106: 117a. DOI: 10.1016/J.Bpj.2013.11.707  0.353
2014 Xie Y, Liao Z, Sato D, Shiferaw Y, Bers DM. Intermittent Early Afterdepolarizations Caused by Bistability Biophysical Journal. 106: 117a. DOI: 10.1016/J.Bpj.2013.11.706  0.527
2014 Pereira L, Erickson J, Chen J, Bers DM. A Novel Fluorescent Epac-Agonist Reveals Epac1 and Epac2 Subcellular Localization in Cardiomyocytes Biophysical Journal. 106: 114a. DOI: 10.1016/J.Bpj.2013.11.691  0.348
2014 Svensson B, Oda T, Nitu FR, Cornea I, Bers DM, Thomas DD, Cornea RL. FRET-Based Trilateration of a Domain Peptide Bound within Functional Ryanodine Receptors in Cardiomyocytes Biophysical Journal. 106: 107a. DOI: 10.1016/J.Bpj.2013.11.658  0.306
2014 Lu X, Bers D. Transient Mitochondrial Permeability Transition Pore Opening in Cardiac Myocytes During SR Ca Release Biophysical Journal. 106: 591a. DOI: 10.1016/J.Bpj.2013.11.3273  0.523
2014 Jian Z, Han H, Zhang T, Puglisi J, Izu LT, Shaw J, Chen Y, Shimkunas R, Chiamvimonvat N, Bers DM, Lam KS, Chen-Izu Y. Localized Nitric Oxide Signaling Mediates Cardiac Mechano-Chemotransduction Biophysical Journal. 106: 566a. DOI: 10.1016/J.Bpj.2013.11.3138  0.523
2014 Sato D, Bers DM. Depolarization of Cardiac Membrane Potential Promotes Calcium Waves Biophysical Journal. 106: 531a. DOI: 10.1016/J.Bpj.2013.11.2966  0.523
2014 Oda T, Yang Y, Nitu FR, Fruen BR, Chen-Izu Y, Cornea RL, Bers DM. In Failing Cardiomyocytes, CaM-RyR2 Dissociation Leads to Defective Domain Interaction and Channel Destabilization Biophysical Journal. 106: 527a. DOI: 10.1016/J.Bpj.2013.11.2943  0.327
2014 Jian Z, Horvath B, Banyazs T, Izu LT, Chen Y, Rajamani S, Ginsburg K, Bossuyt J, Bers DM, Belardinelli L, Chen-Izu Y. Dynamic Late Na Current During Cardiac Action Potential Revealed by a Specific and Potent Inhibitor Gs967 Biophysical Journal. 106: 328a. DOI: 10.1016/J.Bpj.2013.11.1886  0.359
2014 Horvath B, Bers DM. The late sodium current in heart failure: pathophysiology and clinical relevance: Late sodium current in heart failure Esc Heart Failure. 1: 26-40. DOI: 10.1002/2055-5822.12003  0.307
2013 Sato D, Bers DM, Shiferaw Y. Formation of spatially discordant alternans due to fluctuations and diffusion of calcium. Plos One. 8: e85365. PMID 24392005 DOI: 10.1371/Journal.Pone.0085365  0.542
2013 Erickson JR, Pereira L, Wang L, Han G, Ferguson A, Dao K, Copeland RJ, Despa F, Hart GW, Ripplinger CM, Bers DM. Diabetic hyperglycaemia activates CaMKII and arrhythmias by O-linked glycosylation. Nature. 502: 372-6. PMID 24077098 DOI: 10.1038/Nature12537  0.441
2013 Moreno JD, Yang PC, Bankston JR, Grandi E, Bers DM, Kass RS, Clancy CE. Ranolazine for congenital and acquired late INa-linked arrhythmias: in silico pharmacological screening. Circulation Research. 113: e50-61. PMID 23897695 DOI: 10.1161/Circresaha.113.301971  0.348
2013 Awad S, Kunhi M, Little GH, Bai Y, An W, Bers D, Kedes L, Poizat C. Nuclear CaMKII enhances histone H3 phosphorylation and remodels chromatin during cardiac hypertrophy. Nucleic Acids Research. 41: 7656-72. PMID 23804765 DOI: 10.1093/Nar/Gkt500  0.363
2013 Bossuyt J, Bers DM. Visualizing CaMKII and CaM activity: a paradigm of compartmentalized signaling. Journal of Molecular Medicine (Berlin, Germany). 91: 907-16. PMID 23775230 DOI: 10.1007/S00109-013-1060-Y  0.528
2013 Herren AW, Bers DM, Grandi E. Post-translational modifications of the cardiac Na channel: contribution of CaMKII-dependent phosphorylation to acquired arrhythmias. American Journal of Physiology. Heart and Circulatory Physiology. 305: H431-45. PMID 23771687 DOI: 10.1152/Ajpheart.00306.2013  0.447
2013 Pavlovic D, Hall AR, Kennington EJ, Aughton K, Boguslavskyi A, Fuller W, Despa S, Bers DM, Shattock MJ. Nitric oxide regulates cardiac intracellular Na⁺ and Ca²⁺ by modulating Na/K ATPase via PKCε and phospholemman-dependent mechanism. Journal of Molecular and Cellular Cardiology. 61: 164-71. PMID 23612119 DOI: 10.1016/J.Yjmcc.2013.04.013  0.796
2013 Despa S, Bers DM. Na⁺ transport in the normal and failing heart - remember the balance. Journal of Molecular and Cellular Cardiology. 61: 2-10. PMID 23608603 DOI: 10.1016/J.Yjmcc.2013.04.011  0.476
2013 Park CS, Chen S, Lee H, Cha H, Oh JG, Hong S, Han P, Ginsburg KS, Jin S, Park I, Singh VP, Wang HS, Franzini-Armstrong C, Park WJ, Bers DM, et al. Targeted ablation of the histidine-rich Ca(2+)-binding protein (HRC) gene is associated with abnormal SR Ca(2+)-cycling and severe pathology under pressure-overload stress. Basic Research in Cardiology. 108: 344. PMID 23553082 DOI: 10.1007/S00395-013-0344-2  0.569
2013 Thomas RC, Bers DM. How to make calcium-sensitive minielectrodes. Cold Spring Harbor Protocols. 2013: 370-3. PMID 23547153 DOI: 10.1101/Pdb.Prot072850  0.415
2013 Thomas RC, Bers DM. Calcium-sensitive mini- and microelectrodes. Cold Spring Harbor Protocols. 2013: 305-9. PMID 23547145 DOI: 10.1101/Pdb.Top066290  0.447
2013 Lederer WJ, Bers DM, Eisner DA. Calcium signaling in heart: multiscale, diverse, rapid, local, and remarkable. Journal of Molecular and Cellular Cardiology. 58: 3-4. PMID 23500389 DOI: 10.1016/J.Yjmcc.2013.03.003  0.321
2013 Xie Y, Grandi E, Puglisi JL, Sato D, Bers DM. β-adrenergic stimulation activates early afterdepolarizations transiently via kinetic mismatch of PKA targets. Journal of Molecular and Cellular Cardiology. 58: 153-61. PMID 23481579 DOI: 10.1016/J.Yjmcc.2013.02.009  0.6
2013 Neef S, Sag CM, Daut M, Bäumer H, Grefe C, El-Armouche A, DeSantiago J, Pereira L, Bers DM, Backs J, Maier LS. While systolic cardiomyocyte function is preserved, diastolic myocyte function and recovery from acidosis are impaired in CaMKIIδ-KO mice. Journal of Molecular and Cellular Cardiology. 59: 107-16. PMID 23473775 DOI: 10.1016/J.Yjmcc.2013.02.014  0.585
2013 Gold JI, Martini JS, Hullmann J, Gao E, Chuprun JK, Lee L, Tilley DG, Rabinowitz JE, Bossuyt J, Bers DM, Koch WJ. Nuclear translocation of cardiac G protein-Coupled Receptor kinase 5 downstream of select Gq-activating hypertrophic ligands is a calmodulin-dependent process. Plos One. 8: e57324. PMID 23472081 DOI: 10.1371/Journal.Pone.0057324  0.418
2013 Puglisi JL, Negroni JA, Chen-Izu Y, Bers DM. The force-frequency relationship: insights from mathematical modeling. Advances in Physiology Education. 37: 28-34. PMID 23471245 DOI: 10.1152/Advan.00072.2011  0.305
2013 Ginsburg KS, Weber CR, Bers DM. Cardiac Na+-Ca2+ exchanger: dynamics of Ca2+-dependent activation and deactivation in intact myocytes. The Journal of Physiology. 591: 2067-86. PMID 23401616 DOI: 10.1113/Jphysiol.2013.252080  0.737
2013 Pereira L, Cheng H, Lao DH, Na L, van Oort RJ, Brown JH, Wehrens XH, Chen J, Bers DM. Epac2 mediates cardiac β1-adrenergic-dependent sarcoplasmic reticulum Ca2+ leak and arrhythmia. Circulation. 127: 913-22. PMID 23363625 DOI: 10.1161/Circulationaha.12.148619  0.57
2013 Bers DM. Membrane receptor neighborhoods: snuggling up to the nucleus. Circulation Research. 112: 224-6. PMID 23329788 DOI: 10.1161/Circresaha.112.300494  0.496
2013 Bers DM, Shannon TR. Calcium movements inside the sarcoplasmic reticulum of cardiac myocytes. Journal of Molecular and Cellular Cardiology. 58: 59-66. PMID 23321551 DOI: 10.1016/J.Yjmcc.2013.01.002  0.568
2013 Lan F, Lee AS, Liang P, Sanchez-Freire V, Nguyen PK, Wang L, Han L, Yen M, Wang Y, Sun N, Abilez OJ, Hu S, Ebert AD, Navarrete EG, Simmons CS, ... ... Bers DM, et al. Abnormal calcium handling properties underlie familial hypertrophic cardiomyopathy pathology in patient-specific induced pluripotent stem cells. Cell Stem Cell. 12: 101-13. PMID 23290139 DOI: 10.1016/J.Stem.2012.10.010  0.49
2013 Lu X, Ginsburg KS, Kettlewell S, Bossuyt J, Smith GL, Bers DM. Measuring local gradients of intramitochondrial [Ca(2+)] in cardiac myocytes during sarcoplasmic reticulum Ca(2+) release. Circulation Research. 112: 424-31. PMID 23243207 DOI: 10.1161/Circresaha.111.300501  0.565
2013 Oda T, Yang Y, Nitu FR, Svensson B, Lu X, Fruen BR, Cornea RL, Bers DM. In cardiomyocytes, binding of unzipping peptide activates ryanodine receptor 2 and reciprocally inhibits calmodulin binding. Circulation Research. 112: 487-97. PMID 23233753 DOI: 10.1161/Circresaha.111.300290  0.316
2013 Chang CW, Lee L, Yu D, Dao K, Bossuyt J, Bers DM. Acute β-adrenergic activation triggers nuclear import of histone deacetylase 5 and delays G(q)-induced transcriptional activation. The Journal of Biological Chemistry. 288: 192-204. PMID 23161540 DOI: 10.1074/Jbc.M112.382358  0.357
2013 Catalucci D, Zhang DH, DeSantiago J, Aimond F, Barbara G, Chemin J, Bonci D, Picht E, Rusconi F, Dalton ND, Peterson KL, Richard S, Bers DM, Brown JH, Condorelli G. Akt regulates L-type Ca2+ channel activity by modulating Cavα1 protein stability Journal of Cell Biology. 200: 851. DOI: 10.1085/Jgp1334Oia4  0.408
2013 Himes RD, Bossuyt J, Bers DM, Robia SL. Superinhibitory Phospholemman Mutants as Potential Therapeutics for Heart Failure Biophysical Journal. 104: 153a. DOI: 10.1016/J.Bpj.2012.11.868  0.395
2013 Nitu FR, Fruen BR, Rohde D, Most P, Bers DM, Thomas DD, Cornea RL. FRET Detection of CaM-RyR2 Binding Modulation by S100A1 Biophysical Journal. 104: 446a. DOI: 10.1016/J.Bpj.2012.11.2474  0.392
2013 Zhang D, Chai Y, Erickson JR, Brown JH, Bers DM, Lin Y. Functional Modulation of Cardiac ATP-Sensitive Potassium Channels by Nitric Oxide via Intracellular Signaling Biophysical Journal. 104: 24a. DOI: 10.1016/J.Bpj.2012.11.167  0.388
2012 Chen L, Liu T, Tran A, Lu X, Tomilov AA, Davies V, Cortopassi G, Chiamvimonvat N, Bers DM, Votruba M, Knowlton AA. OPA1 mutation and late-onset cardiomyopathy: mitochondrial dysfunction and mtDNA instability. Journal of the American Heart Association. 1: e003012. PMID 23316298 DOI: 10.1161/Jaha.112.003012  0.306
2012 Khafaga M, Bossuyt J, Mamikonian L, Li JC, Lee LL, Yarov-Yarovoy V, Despa S, Bers DM. Na⁺/K⁺-ATPase E960 and phospholemman F28 are critical for their functional interaction. Proceedings of the National Academy of Sciences of the United States of America. 109: 20756-61. PMID 23185013 DOI: 10.1073/Pnas.1207866109  0.336
2012 Bers DM, Herren AW. Na(+) channel I-II loop mediates parallel genetic and phosphorylation-dependent gating changes. Circulation. 126: 2042-6. PMID 23091083 DOI: 10.1161/Circulationaha.112.140384  0.428
2012 Sato D, Despa S, Bers DM. Can the sodium-calcium exchanger initiate or suppress calcium sparks in cardiac myocytes? Biophysical Journal. 102: L31-3. PMID 22768959 DOI: 10.1016/J.Bpj.2012.03.051  0.571
2012 Despa S, Lingrel JB, Bers DM. Na(+)/K)+)-ATPase α2-isoform preferentially modulates Ca2(+) transients and sarcoplasmic reticulum Ca2(+) release in cardiac myocytes. Cardiovascular Research. 95: 480-6. PMID 22739122 DOI: 10.1093/Cvr/Cvs213  0.594
2012 Guo T, Zhang T, Ginsburg KS, Mishra S, Brown JH, Bers DM. CaMKIIδC slows [Ca]i decline in cardiac myocytes by promoting Ca sparks. Biophysical Journal. 102: 2461-70. PMID 22713561 DOI: 10.1016/J.Bpj.2012.04.015  0.65
2012 Morotti S, Grandi E, Summa A, Ginsburg KS, Bers DM. Theoretical study of L-type Ca(2+) current inactivation kinetics during action potential repolarization and early afterdepolarizations. The Journal of Physiology. 590: 4465-81. PMID 22586219 DOI: 10.1113/Jphysiol.2012.231886  0.564
2012 Myles RC, Wang L, Kang C, Bers DM, Ripplinger CM. Local β-adrenergic stimulation overcomes source-sink mismatch to generate focal arrhythmia. Circulation Research. 110: 1454-64. PMID 22539768 DOI: 10.1161/Circresaha.111.262345  0.538
2012 Ashpole NM, Herren AW, Ginsburg KS, Brogan JD, Johnson DE, Cummins TR, Bers DM, Hudmon A. Ca2+/calmodulin-dependent protein kinase II (CaMKII) regulates cardiac sodium channel NaV1.5 gating by multiple phosphorylation sites. The Journal of Biological Chemistry. 287: 19856-69. PMID 22514276 DOI: 10.1074/Jbc.M111.322537  0.464
2012 Bers DM. Ryanodine receptor S2808 phosphorylation in heart failure: smoking gun or red herring. Circulation Research. 110: 796-9. PMID 22427320 DOI: 10.1161/Circresaha.112.265579  0.491
2012 Camors E, Mohler PJ, Bers DM, Despa S. Ankyrin-B reduction enhances Ca spark-mediated SR Ca release promoting cardiac myocyte arrhythmic activity. Journal of Molecular and Cellular Cardiology. 52: 1240-8. PMID 22406428 DOI: 10.1016/J.Yjmcc.2012.02.010  0.598
2012 Despa S, Margulies KB, Chen L, Knowlton AA, Havel PJ, Taegtmeyer H, Bers DM, Despa F. Hyperamylinemia contributes to cardiac dysfunction in obesity and diabetes: a study in humans and rats. Circulation Research. 110: 598-608. PMID 22275486 DOI: 10.1161/Circresaha.111.258285  0.342
2012 Haghighi K, Pritchard T, Bossuyt J, Waggoner JR, Yuan Q, Fan GC, Osinska H, Anjak A, Rubinstein J, Robbins J, Bers DM, Kranias EG. The human phospholamban Arg14-deletion mutant localizes to plasma membrane and interacts with the Na/K-ATPase. Journal of Molecular and Cellular Cardiology. 52: 773-82. PMID 22155237 DOI: 10.1016/J.Yjmcc.2011.11.012  0.546
2012 Goonasekera SA, Hammer K, Auger-Messier M, Bodi I, Chen X, Zhang H, Reiken S, Elrod JW, Correll RN, York AJ, Sargent MA, Hofmann F, Moosmang S, Marks AR, Houser SR, ... Bers DM, et al. Decreased cardiac L-type Ca²⁺ channel activity induces hypertrophy and heart failure in mice. The Journal of Clinical Investigation. 122: 280-90. PMID 22133878 DOI: 10.1172/Jci58227  0.422
2012 Pereira L, Ruiz-Hurtado G, Morel E, Laurent AC, Métrich M, Domínguez-Rodríguez A, Lauton-Santos S, Lucas A, Benitah JP, Bers DM, Lezoualc'h F, Gómez AM. Epac enhances excitation-transcription coupling in cardiac myocytes. Journal of Molecular and Cellular Cardiology. 52: 283-91. PMID 22056318 DOI: 10.1016/J.Yjmcc.2011.10.016  0.594
2012 Saucerman JJ, Bers DM. Calmodulin binding proteins provide domains of local Ca2+ signaling in cardiac myocytes. Journal of Molecular and Cellular Cardiology. 52: 312-6. PMID 21708171 DOI: 10.1016/J.Yjmcc.2011.06.005  0.733
2012 Shannon T, Wang F, Puglisi J, Weber C, Bers D. Correction Biophysical Journal. 102: 1996-2001. DOI: 10.1016/J.Bpj.2012.03.034  0.474
2012 Hamada H, Sato D, Luis Puglisi J, Xie Y, Grandi E, Okamoto M, Savageau MA, Bers DM. Contribution of Calcium Waves to the Regulation of Beating Rhythm in Sinoatrial Node Cells Biophysical Journal. 102: 673a. DOI: 10.1016/J.Bpj.2011.11.3663  0.514
2012 Puglisi JL, Izu L, Chen-Izu Y, Bers DM. Feed Forward Modeling. Fixing the Force Frequency Relationship Biophysical Journal. 102: 552a-553a. DOI: 10.1016/J.Bpj.2011.11.3013  0.356
2012 Xie Y, Sato D, Bers DM. Transitions Among Excitable, Oscillatory and Non-Excitable in Simplified Calcium Cycling Model Biophysical Journal. 102: 309a. DOI: 10.1016/J.Bpj.2011.11.1703  0.56
2012 Fruen BR, Nitu F, Nguyen T, Oda T, Yang Y, Thomas DD, Bers DM, Cornea RL. FRET Detection of RyR2 Calmodulin Binding and Calcium-Dependent Modulation by RyR22460-2495 Peptide (DPc10) Biophysical Journal. 102: 306a. DOI: 10.1016/J.Bpj.2011.11.1689  0.463
2012 Bers DM, Houser SR. Calcium fluxes and homeostasis Muscle. 1: 141-152. DOI: 10.1016/B978-0-12-381510-1.00011-9  0.591
2012 Ling H, Zhang T, Pereira L, Means CK, Cheng H, Gu Y, Dalton ND, Peterson KL, Chen J, Bers D, Brown JH. Requirement for Ca 2+/calmodulin-dependent kinase II in the transition from pressure overload-induced cardiac hypertrophy to heart failure in mice (Journal of Clinical Investigation (2009) 119, 5, (1230-1240) doi:10.1172/JCI38022) Journal of Clinical Investigation. 122: 1584.  0.373
2011 Bers DM, Grandi E. Human atrial fibrillation: insights from computational electrophysiological models. Trends in Cardiovascular Medicine. 21: 145-50. PMID 22732550 DOI: 10.1016/J.Tcm.2012.04.004  0.309
2011 Sato D, Bers DM. How does stochastic ryanodine receptor-mediated Ca leak fail to initiate a Ca spark? Biophysical Journal. 101: 2370-9. PMID 22098735 DOI: 10.1016/J.Bpj.2011.10.017  0.56
2011 Guo T, Fruen BR, Nitu FR, Nguyen TD, Yang Y, Cornea RL, Bers DM. FRET detection of calmodulin binding to the cardiac RyR2 calcium release channel. Biophysical Journal. 101: 2170-7. PMID 22067155 DOI: 10.1016/J.Bpj.2011.09.030  0.535
2011 Mishra S, Gray CB, Miyamoto S, Bers DM, Brown JH. Location matters: clarifying the concept of nuclear and cytosolic CaMKII subtypes. Circulation Research. 109: 1354-62. PMID 21998325 DOI: 10.1161/Circresaha.111.248401  0.453
2011 Grandi E, Pandit SV, Voigt N, Workman AJ, Dobrev D, Jalife J, Bers DM. Human atrial action potential and Ca2+ model: sinus rhythm and chronic atrial fibrillation. Circulation Research. 109: 1055-66. PMID 21921263 DOI: 10.1161/Circresaha.111.253955  0.527
2011 Erickson JR, Patel R, Ferguson A, Bossuyt J, Bers DM. Fluorescence resonance energy transfer-based sensor Camui provides new insight into mechanisms of calcium/calmodulin-dependent protein kinase II activation in intact cardiomyocytes. Circulation Research. 109: 729-38. PMID 21835909 DOI: 10.1161/Circresaha.111.247148  0.425
2011 Bossuyt J, Chang CW, Helmstadter K, Kunkel MT, Newton AC, Campbell KS, Martin JL, Bossuyt S, Robia SL, Bers DM. Spatiotemporally distinct protein kinase D activation in adult cardiomyocytes in response to phenylephrine and endothelin. The Journal of Biological Chemistry. 286: 33390-400. PMID 21795686 DOI: 10.1074/Jbc.M111.246447  0.792
2011 Sadayappan S, Gulick J, Osinska H, Barefield D, Cuello F, Avkiran M, Lasko VM, Lorenz JN, Maillet M, Martin JL, Brown JH, Bers DM, Molkentin JD, James J, Robbins J. A critical function for Ser-282 in cardiac Myosin binding protein-C phosphorylation and cardiac function. Circulation Research. 109: 141-50. PMID 21597010 DOI: 10.1161/Circresaha.111.242560  0.345
2011 Bers DM, Harris SP. Translational medicine: to the rescue of the failing heart. Nature. 473: 36-9. PMID 21544138 DOI: 10.1038/473036A  0.313
2011 Wu L, Ma J, Li H, Wang C, Grandi E, Zhang P, Luo A, Bers DM, Shryock JC, Belardinelli L. Late sodium current contributes to the reverse rate-dependent effect of IKr inhibition on ventricular repolarization. Circulation. 123: 1713-20. PMID 21482963 DOI: 10.1161/Circulationaha.110.000661  0.354
2011 Bers DM. Calmodulin and S100A1 fine tune skeletal muscle E-C coupling. Focus on "Modulation of sarcoplasmic reticulum Ca2+ release in skeletal muscle expressing ryanodine receptor impaired in regulation by calmodulin and S100A1". American Journal of Physiology. Cell Physiology. 300: C974-5. PMID 21346150 DOI: 10.1152/Ajpcell.00051.2011  0.461
2011 Picht E, Zima AV, Shannon TR, Duncan AM, Blatter LA, Bers DM. Dynamic calcium movement inside cardiac sarcoplasmic reticulum during release. Circulation Research. 108: 847-56. PMID 21311044 DOI: 10.1161/Circresaha.111.240234  0.546
2011 Anderson ME, Brown JH, Bers DM. CaMKII in myocardial hypertrophy and heart failure. Journal of Molecular and Cellular Cardiology. 51: 468-73. PMID 21276796 DOI: 10.1016/J.Yjmcc.2011.01.012  0.44
2011 Bers DM. Ca²⁺-calmodulin-dependent protein kinase II regulation of cardiac excitation-transcription coupling. Heart Rhythm : the Official Journal of the Heart Rhythm Society. 8: 1101-4. PMID 21255680 DOI: 10.1016/J.Hrthm.2011.01.030  0.57
2011 Wagner S, Ruff HM, Weber SL, Bellmann S, Sowa T, Schulte T, Anderson ME, Grandi E, Bers DM, Backs J, Belardinelli L, Maier LS. Reactive oxygen species-activated Ca/calmodulin kinase IIδ is required for late I(Na) augmentation leading to cellular Na and Ca overload. Circulation Research. 108: 555-65. PMID 21252154 DOI: 10.1161/Circresaha.110.221911  0.554
2011 Song Q, Pallikkuth S, Bossuyt J, Bers DM, Robia SL. Phosphomimetic mutations enhance oligomerization of phospholemman and modulate its interaction with the Na/K-ATPase Journal of Biological Chemistry. 286: 9120-9126. PMID 21220422 DOI: 10.1074/Jbc.M110.198036  0.321
2011 Puglisi JL, Yuan W, Timofeyev V, Myers RE, Chiamvimonvat N, Samarel AM, Bers DM. Phorbol ester and endothelin-1 alter functional expression of Na+/Ca2+ exchange, K+, and Ca2+ currents in cultured neonatal rat myocytes. American Journal of Physiology. Heart and Circulatory Physiology. 300: H617-26. PMID 21131481 DOI: 10.1152/Ajpheart.00388.2010  0.507
2011 Huke S, Desantiago J, Kaetzel MA, Mishra S, Brown JH, Dedman JR, Bers DM. SR-targeted CaMKII inhibition improves SR Ca²+ handling, but accelerates cardiac remodeling in mice overexpressing CaMKIIδC. Journal of Molecular and Cellular Cardiology. 50: 230-8. PMID 20971119 DOI: 10.1016/J.Yjmcc.2010.10.014  0.568
2011 Yu D, Bossuyt J, Erickson J, Norton B, Sumandea MP, Izu LT, Bers DM, Chen-Izu Y. Changes in Ca2+/Calmodulin-Dependent Protein Kinase (CaMKII) During Development of Hypertension-Induced Hypertrophy and Heart Failure Biophysical Journal. 100: 85a. DOI: 10.1016/J.Bpj.2010.12.670  0.407
2011 Helmstadter KG, Erickson JR, Dao K, Bossuyt J, Bers DM. Beta-Adrenergic Activation Enhances Histone Deacetylase 4 nuclear Localization via Pka and Counters Camkii-Dependent Effects in Adult Rabbit Cardiac Myocytes Biophysical Journal. 100: 80a. DOI: 10.1016/J.Bpj.2010.12.646  0.786
2011 Morotti S, Grandi E, Summa A, Ginsburg K, Severi S, Bers DM. An Improved Model of Voltage- and Ca-Dependent Inactivation of the L-Type Ca Channels Biophysical Journal. 100: 571a. DOI: 10.1016/J.Bpj.2010.12.3308  0.565
2011 Xu H, Ginsburg K, Hall D, Zimmermann M, Zhang M, Tandan S, Hill J, Horne M, Bers DM, Hell J. Targeting of Protein Phosphatases PP2A and PP2B to the C Terminus of L-Type Calcium Channel CaV1.2 Biophysical Journal. 100: 571a. DOI: 10.1016/J.Bpj.2010.12.3306  0.372
2011 Sato D, Bers DM. How Does RyR2-Mediated SR Calcium Leak Fail to Cause Sparks? Biophysical Journal. 100: 557a-558a. DOI: 10.1016/J.Bpj.2010.12.3241  0.56
2011 Khafaga M, Bossuyt J, Li JC, Lee LL, Elliott JH, Despa S, Bers DM. Na Pump E960 Site is Critical for the Interaction with Phospholemman Biophysical Journal. 100: 464a. DOI: 10.1016/J.Bpj.2010.12.2726  0.334
2011 Grandi E, Pandit SV, Voigt N, Workman AJ, Dobrev D, Jalife J, Bers DM. Models of Human Atrial Action Potential for Sinus Rhythm and Chronic Atrial Fibrillation Biophysical Journal. 100: 436a. DOI: 10.1016/J.Bpj.2010.12.2571  0.511
2011 Herren AW, Ashpole NM, Ginsburg KS, Bers DM, Hudmon A. CaMKII Regulates Cardiac Sodium Channel Nav1.5 by Phosphorylation in the Loop Between Domain I and II Biophysical Journal. 100: 421a. DOI: 10.1016/J.Bpj.2010.12.2491  0.44
2011 Yang Y, Chakraborty A, Guo T, Cornea RL, Meissner G, Bers DM. In Situ Measurement of RyR2-Calmodulin Binding in Permeabilized Cardiomyocytes Biophysical Journal. 100: 413a-414a. DOI: 10.1016/J.Bpj.2010.12.2450  0.531
2011 Hammer KP, Goonasekera SA, Bodi I, Moosmang S, Hofmann F, Molkentin JD, Bers DM. Suppression of Cardiac L-Type Ca Channel Activity Causes Cardiac Hypertrophy Biophysical Journal. 100: 291a. DOI: 10.1016/J.Bpj.2010.12.1793  0.603
2011 Lal RA, Puglisi JL, Wulff H, Bers DM. A new Mathematical Formulation of the Plasma Membrane Ca2+-Atpase (PMCA) Provides Stability to Simulated Ca2+ Signaling in Human T Cells Biophysical Journal. 100: 260a-261a. DOI: 10.1016/J.Bpj.2010.12.1638  0.56
2011 Despa S, Koch B, Margulies KB, Bers D, Despa F. Intrinsically Disordered Islet Amyloid Polypeptide Is a Pathogenic Link Between Type-2 diabetes and Heart Disease Biophysical Journal. 100: 229a. DOI: 10.1016/J.Bpj.2010.12.1467  0.449
2011 Bers DM. Regulation of Cellular Calcium in Cardiac Myocytes Comprehensive Physiology. DOI: 10.1002/Cphy.Cp020109  0.578
2010 van Oort RJ, McCauley MD, Dixit SS, Pereira L, Yang Y, Respress JL, Wang Q, De Almeida AC, Skapura DG, Anderson ME, Bers DM, Wehrens XH. Ryanodine receptor phosphorylation by calcium/calmodulin-dependent protein kinase II promotes life-threatening ventricular arrhythmias in mice with heart failure. Circulation. 122: 2669-79. PMID 21098440 DOI: 10.1161/Circulationaha.110.982298  0.562
2010 Xu H, Ginsburg KS, Hall DD, Zimmermann M, Stein IS, Zhang M, Tandan S, Hill JA, Horne MC, Bers D, Hell JW. Targeting of protein phosphatases PP2A and PP2B to the C-terminus of the L-type calcium channel Ca v1.2. Biochemistry. 49: 10298-307. PMID 21053940 DOI: 10.1021/Bi101018C  0.562
2010 Hove-Madsen L, Baudet S, Bers DM. Making and using calcium-selective mini- and microelectrodes Methods in Cell Biology. 99: 67-89. PMID 21035683 DOI: 10.1016/B978-0-12-374841-6.00003-7  0.494
2010 Bers DM, Patton CW, Nuccitelli R. A practical guide to the preparation of Ca2+ buffers Methods in Cell Biology. 99: 1-26. PMID 21035681 DOI: 10.1016/B978-0-12-374841-6.00001-3  0.542
2010 Bers DM. CaMKII inhibition in heart failure makes jump to human Circulation Research. 107: 1044-1046. PMID 21030721 DOI: 10.1161/Circresaha.110.231902  0.474
2010 Zima AV, Bovo E, Bers DM, Blatter LA. Ca2+ spark-dependent and -independent sarcoplasmic reticulum Ca2+ leak in normal and failing rabbit ventricular myocytes Journal of Physiology. 588: 4743-4757. PMID 20962003 DOI: 10.1113/Jphysiol.2010.197913  0.565
2010 Han F, Bossuyt J, Martin JL, Despa S, Bers DM. Role of phospholemman phosphorylation sites in mediating kinase-dependent regulation of the Na+-K+-ATPase. American Journal of Physiology. Cell Physiology. 299: C1363-9. PMID 20861470 DOI: 10.1152/Ajpcell.00027.2010  0.51
2010 Bers DM. Digitalis and Na/Ca exchange: Old dog learns new mitochondrial tricks Journal of Molecular and Cellular Cardiology. 49: 713-714. PMID 20708015 DOI: 10.1016/J.Yjmcc.2010.08.004  0.601
2010 Nakayama H, Bodi I, Maillet M, DeSantiago J, Domeier TL, Mikoshiba K, Lorenz JN, Blatter LA, Bers DM, Molkentin JD. The IP3 receptor regulates cardiac hypertrophy in response to select stimuli. Circulation Research. 107: 659-66. PMID 20616315 DOI: 10.1161/Circresaha.110.220038  0.463
2010 Mishra S, Ling H, Grimm M, Zhang T, Bers DM, Brown JH. Cardiac hypertrophy and heart failure development through Gq and CaM kinase II signaling. Journal of Cardiovascular Pharmacology. 56: 598-603. PMID 20531218 DOI: 10.1097/Fjc.0B013E3181E1D263  0.518
2010 Santiago DJ, Curran JW, Bers DM, Lederer WJ, Stern MD, Ríos E, Shannon TR. Ca sparks do not explain all ryanodine receptor-mediated SR Ca leak in mouse ventricular myocytes. Biophysical Journal. 98: 2111-20. PMID 20483318 DOI: 10.1016/J.Bpj.2010.01.042  0.559
2010 Guo T, Cornea RL, Huke S, Camors E, Yang Y, Picht E, Fruen BR, Bers DM. Kinetics of FKBP12.6 binding to ryanodine receptors in permeabilized cardiac myocytes and effects on Ca sparks. Circulation Research. 106: 1743-52. PMID 20431056 DOI: 10.1161/Circresaha.110.219816  0.587
2010 Curran J, Brown KH, Santiago DJ, Pogwizd S, Bers DM, Shannon TR. Spontaneous Ca waves in ventricular myocytes from failing hearts depend on Ca2+-calmodulin-dependent protein kinase II Journal of Molecular and Cellular Cardiology. 49: 25-32. PMID 20353795 DOI: 10.1016/J.Yjmcc.2010.03.013  0.611
2010 Rinne A, Kapur N, Molkentin JD, Pogwizd SM, Bers DM, Banach K, Blatter LA. Isoform- and tissue-specific regulation of the Ca2+-sensitive transcription factor NFAT in cardiac myocytes and heart failure American Journal of Physiology - Heart and Circulatory Physiology. 298: H2001-H2009. PMID 20304816 DOI: 10.1152/Ajpheart.01072.2009  0.567
2010 Bers DM. Editorial: Calcium channels are ganging up in the sarcolemma Circulation Research. 106: 625-626. PMID 20203310 DOI: 10.1161/Circresaha.109.216028  0.58
2010 Grandi E, Morotti S, Ginsburg KS, Severi S, Bers DM. Interplay of voltage and Ca-dependent inactivation of L-type Ca current Progress in Biophysics and Molecular Biology. 103: 44-50. PMID 20184915 DOI: 10.1016/J.Pbiomolbio.2010.02.001  0.525
2010 Bers DM, Ginsburg KS. Editorial: Minding the store of Ca2+ during ischaemia/ reperfusion Cardiovascular Research. 85: 641-642. PMID 20056726 DOI: 10.1093/Cvr/Cvp423  0.574
2010 Zhang T, Guo T, Mishra S, Dalton ND, Kranias EG, Peterson KL, Bers DM, Brown JH. Phospholamban ablation rescues sarcoplasmic reticulum Ca(2+) handling but exacerbates cardiac dysfunction in CaMKIIdelta(C) transgenic mice. Circulation Research. 106: 354-62. PMID 19959778 DOI: 10.1161/Circresaha.109.207423  0.642
2010 Grandi E, Pasqualini FS, Bers DM. A novel computational model of the human ventricular action potential and Ca transient Journal of Molecular and Cellular Cardiology. 48: 112-121. PMID 19835882 DOI: 10.1016/J.Bpj.2008.12.3513  0.546
2010 Bers DM, Zhu Y. Excitation-Contraction Coupling and Cardiac Contractile Force Journal of Cardiovascular Disease Research. 1: 45. DOI: 10.1016/S0975-3583(10)11011-0  0.579
2010 Song Q, Bossuyt J, Kaur K, Bers DM, Robia SL. Phosphomimetic Mutations Increase FXYD1 Oligomerization, but Does Not Alter its Quaternary Conformation Biophysical Journal. 98: 171a. DOI: 10.1016/J.Bpj.2009.12.922  0.331
2010 Curran J, Bers DM, Shannon TR. Nitric Oxide Can Mediate Beta-Adrenergic- and CaMKII-Dependent Spontaneous Ca2+ Waves in Cardiac Myocytes, Independent of PKA Activation Biophysical Journal. 98: 102a. DOI: 10.1016/J.Bpj.2009.12.569  0.573
2010 Camors E, Mohler PJ, Bers DM, Despa S. Increased Ca Sparks and Waves Frequency and Unchanged [Na]i in Hearts from Ankyrin-B Heterozygous Mice Biophysical Journal. 98: 714a. DOI: 10.1016/J.Bpj.2009.12.3913  0.553
2010 Sato D, Bers DM. Cardiac Action Potential Model with Spatial Subcellular Calcium Cycling and Physiological Transmembrane Currents Biophysical Journal. 98: 711a. DOI: 10.1016/J.Bpj.2009.12.3898  0.567
2010 Puglisi JL, Negroni JA, Bers DM. In Silico Studies of Cardiac Inotropy using a New Model of Force Generation Biophysical Journal. 98: 514a. DOI: 10.1016/J.Bpj.2009.12.2799  0.565
2010 Grandi E, Bers DM. Action Potential Duration Adaptation and Reverse-Rate Dependency in Human Ventricular Myocytes: Insights from a Computer Model Biophysical Journal. 98: 334a. DOI: 10.1016/J.Bpj.2009.12.1811  0.463
2010 Chang CJ, Helmstadter K, Mignery G, Bossuyt J, Bers D. Endothelin and Phenylephrine Both Trigger Nuclear IP3 Elevation, but Differ in Ability to Activate Nuclear HDAC5 Export Biophysical Journal. 98: 308a-309a. DOI: 10.1016/J.Bpj.2009.12.1678  0.783
2010 Yang Y, Pereira L, van Oort RJ, Wehrens XH, Bers DM. Ca SR Leak is Modulated by CaMKII Phosphorylation on RyR2-S2814 Biophysical Journal. 98: 303a. DOI: 10.1016/J.Bpj.2009.12.1648  0.585
2010 Guo T, Cornea R, Huke S, Camors E, Yang Y, Picht E, Fruen B, Bers D. FKBP12.6 Inhibits Resting Ryanodine Receptor Activity but PKA-Dependent Phosphorylation Does Not Alter FKBP12.6-RyR2 Binding in Rat Permeabilized Myocytes Biophysical Journal. 98: 299a. DOI: 10.1016/J.Bpj.2009.12.1627  0.409
2010 Despa S, Andronic F, Thai P, Walton JH, Margulies KB, Bers DM, Despa F. Iapp Preamyloid Oligomers Accumulate in the Heart and Contribute to Cardiac Dysfunction in Type-2 Diabetes Biophysical Journal. 98: 255a. DOI: 10.1016/J.Bpj.2009.12.1386  0.363
2010 Ginsburg K, Bers DM. Cytosolic Ca-Dependent Na/Ca Exchange Regulation in Intact Cardiomyocytes: Role of Cytosolic Na Biophysical Journal. 98: 21a-22a. DOI: 10.1016/J.Bpj.2009.12.129  0.58
2010 Despa S, Wu Y, Lingrel JB, Stefani E, Bers D. Na/K-ATpase α2-Subunit Preferentially Modulates Ca Transients and SR Ca Release in Cardiac Myocytes Biophysical Journal. 98: 201a-202a. DOI: 10.1016/J.Bpj.2009.12.1075  0.532
2010 Morotti S, Grandi E, Summa A, Ginsburg KS, Bers DM, Severi S. An improved model of Ba current through L-type Ca channels including voltage- and ion-dependent inactivation Computing in Cardiology. 37: 645-648.  0.308
2009 Bers DM, Despa S. Na/K-ATPase-An Integral Player in the Adrenergic Fight-or-Flight Response Trends in Cardiovascular Medicine. 19: 111-118. PMID 19818946 DOI: 10.1016/J.Tcm.2009.07.001  0.59
2009 Wagner S, Hacker E, Grandi E, Weber SL, Dybkova N, Sossalla S, Sowa T, Fabritz L, Kirchhof P, Bers DM, Maier LS. Ca/calmodulin kinase II differentially modulates potassium currents Circulation: Arrhythmia and Electrophysiology. 2: 285-294. PMID 19808479 DOI: 10.1161/Circep.108.842799  0.392
2009 Schaeffer PJ, Desantiago J, Yang J, Flagg TP, Kovacs A, Weinheimer CJ, Courtois M, Leone TC, Nichols CG, Bers DM, Kelly DP. Impaired contractile function and calcium handling in hearts of cardiac-specific calcineurin b1-deficient mice. American Journal of Physiology. Heart and Circulatory Physiology. 297: H1263-73. PMID 19700627 DOI: 10.1152/Ajpheart.00152.2009  0.457
2009 Bossuyt J, Despa S, Han F, Hou Z, Robia SL, Lingrel JB, Bers DM. Isoform specificity of the Na/K-ATPase association and regulation by phospholemman. The Journal of Biological Chemistry. 284: 26749-57. PMID 19638348 DOI: 10.1074/Jbc.M109.047357  0.431
2009 Han F, Tucker AL, Lingrel JB, Despa S, Bers DM. Extracellular potassium dependence of the Na+-K+-ATPase in cardiac myocytes: isoform specificity and effect of phospholemman. American Journal of Physiology. Cell Physiology. 297: C699-705. PMID 19570895 DOI: 10.1152/Ajpcell.00063.2009  0.499
2009 Ling H, Zhang T, Pereira L, Means CK, Cheng H, Gu Y, Dalton ND, Peterson KL, Chen J, Bers D, Brown JH, Heller Brown J. Requirement for Ca2+/calmodulin-dependent kinase II in the transition from pressure overload-induced cardiac hypertrophy to heart failure in mice. The Journal of Clinical Investigation. 119: 1230-40. PMID 19381018 DOI: 10.1172/Jci38022  0.465
2009 Andrienko TN, Picht E, Bers DM. Mitochondrial free calcium regulation during sarcoplasmic reticulum calcium release in rat cardiac myocytes Journal of Molecular and Cellular Cardiology. 46: 1027-1036. PMID 19345225 DOI: 10.1016/J.Yjmcc.2009.03.015  0.566
2009 Bers DM, Grandi E. Calcium/calmodulin-dependent kinase II regulation of cardiac ion channels Journal of Cardiovascular Pharmacology. 54: 180-187. PMID 19333131 DOI: 10.1097/Fjc.0B013E3181A25078  0.399
2009 Catalucci D, Zhang DH, DeSantiago J, Aimond F, Barbara G, Chemin J, Bonci D, Picht E, Rusconi F, Dalton ND, Peterson KL, Richard S, Bers DM, Brown JH, Condorelli G. Akt regulates L-type Ca2+ channel activity by modulating Cavalpha1 protein stability. The Journal of Cell Biology. 184: 923-33. PMID 19307602 DOI: 10.1083/Jcb.200805063  0.548
2009 Murphy E, Bers DM, Rizzuto R. Mitochondria: from basic biology to cardiovascular disease. Journal of Molecular and Cellular Cardiology. 46: 765-766. PMID 19289126 DOI: 10.1016/J.Yjmcc.2009.03.004  0.479
2009 Bers DM, Despa S. Na+ transport in cardiac myocytes; Implications for excitation-contraction coupling. Iubmb Life. 61: 215-21. PMID 19243007 DOI: 10.1002/iub.163  0.497
2009 Waggoner JR, Ginsburg KS, Mitton B, Haghighi K, Robbins J, Bers DM, Kranias EG. Phospholamban overexpression in rabbit ventricular myocytes does not alter sarcoplasmic reticulum Ca transport. American Journal of Physiology. Heart and Circulatory Physiology. 296: H698-703. PMID 19112098 DOI: 10.1152/Ajpheart.00272.2008  0.598
2009 Lal R, Puglisi JL, Wulff H, Bers DM. Ca++T LAB - A Computational Model for Intracellular Calcium Signaling In T Lymphocytes Biophysical Journal. 96: 122a. DOI: 10.1016/J.Bpj.2008.12.541  0.479
2009 Curran J, Ahmed U, Bers DM, Ziolo M, Shannon TR. Isoproterenol-Enhanced Diastolic Sarcoplasmic Reticulum Ca Leak in Ventricular Myocytes Requires Activation of Nitric Oxide Synthase Biophysical Journal. 96: 120a-121a. DOI: 10.1016/J.Bpj.2008.12.533  0.568
2009 Rinne A, Banach K, Bers DM, Blatter LA. Isoform-specific Regulation Of The Ca-sensitive Transcription Factor NFAT In The Cardiovascular System Biophysical Journal. 96: 559a. DOI: 10.1016/J.Bpj.2008.12.3668  0.523
2009 Ai X, Zhao W, Bers D, Pogwizd SM. Sex Differences Of RyR2 Expression And Phosphorylation In Heart Failure Biophysical Journal. 96: 551a. DOI: 10.1016/J.Bpj.2008.12.2983  0.364
2009 DeSantiago J, Zima AV, Domeier TL, Ginsburg K, Molkentin JD, Blatter LA, Bers DM. IP3 Receptor-mediated Ca Release Facilitates RyR-Ca Release To Cause Inotropy And Arrhythmogenicity In Mouse Ventricular Myocytes Biophysical Journal. 96: 540a. DOI: 10.1016/J.Bpj.2008.12.2790  0.506
2009 Bers DM, Despa S. Na+ transport in cardiac myocytes; implications for excitation-contraction coupling Iubmb Life. 61: 215-221. DOI: 10.1002/Iub.163  0.58
2008 Song Q, Saucerman JJ, Bossuyt J, Bers DM. Differential integration of Ca2+-calmodulin signal in intact ventricular myocytes at low and high affinity Ca2+-calmodulin targets. The Journal of Biological Chemistry. 283: 31531-40. PMID 18790737 DOI: 10.1074/Jbc.M804902200  0.761
2008 Zima AV, Picht E, Bers DM, Blatter LA. Termination of cardiac Ca2+ sparks: Role of intra-SR [Ca2+], release flux, and intra-SR Ca2+ diffusion Circulation Research. 103: e105-e115. PMID 18787194 DOI: 10.1161/Circresaha.107.183236  0.542
2008 Rudy Y, Ackerman MJ, Bers DM, Clancy CE, Houser SR, London B, McCulloch AD, Przywara DA, Rasmusson RL, Solaro RJ, Trayanova NA, Van Wagoner DR, Varró A, Weiss JN, Lathrop DA. Systems approach to understanding electromechanical activity in the human heart: a national heart, lung, and blood institute workshop summary. Circulation. 118: 1202-11. PMID 18779456 DOI: 10.1161/Circulationaha.108.772715  0.633
2008 Huke S, Bers DM. Ryanodine receptor phosphorylation at Serine 2030, 2808 and 2814 in rat cardiomyocytes Biochemical and Biophysical Research Communications. 376: 80-85. PMID 18755143 DOI: 10.1016/J.Bbrc.2008.08.084  0.392
2008 Saucerman JJ, Bers DM. Calmodulin mediates differential sensitivity of CaMKII and calcineurin to local Ca2+ in cardiac myocytes. Biophysical Journal. 95: 4597-612. PMID 18689454 DOI: 10.1529/Biophysj.108.128728  0.77
2008 Terentyev D, Kubalova Z, Valle G, Nori A, Vedamoorthyrao S, Terentyeva R, Viatchenko-Karpinski S, Bers DM, Williams SC, Volpe P, Gyorke S. Modulation of SR Ca release by luminal Ca and calsequestrin in cardiac myocytes: Effects of CASQ2 mutations linked to sudden cardiac death Biophysical Journal. 95: 2037-2048. PMID 18469084 DOI: 10.1529/Biophysj.107.128249  0.574
2008 Desantiago J, Ai X, Islam M, Acuna G, Ziolo MT, Bers DM, Pogwizd SM. Arrhythmogenic effects of beta2-adrenergic stimulation in the failing heart are attributable to enhanced sarcoplasmic reticulum Ca load. Circulation Research. 102: 1389-97. PMID 18467626 DOI: 10.1161/CIRCRESAHA.107.169011  0.399
2008 Despa S, Tucker AL, Bers DM. Phospholemman-mediated activation of Na/K-ATPase limits [Na]i and inotropic state during β-adrenergic stimulation in mouse ventricular myocytes Circulation. 117: 1849-1855. PMID 18362230 DOI: 10.1161/Circulationaha.107.754051  0.447
2008 Rice JJ, Wang F, Bers DM, de Tombe PP. Approximate model of cooperative activation and crossbridge cycling in cardiac muscle using ordinary differential equations. Biophysical Journal. 95: 2368-90. PMID 18234826 DOI: 10.1529/Biophysj.107.119487  0.469
2008 Bossuyt J, Helmstadter K, Wu X, Clements-Jewery H, Haworth RS, Avkiran M, Martin JL, Pogwizd SM, Bers DM. Ca2+/calmodulin-dependent protein kinase IIdelta and protein kinase D overexpression reinforce the histone deacetylase 5 redistribution in heart failure. Circulation Research. 102: 695-702. PMID 18218981 DOI: 10.1161/Circresaha.107.169755  0.799
2008 Zima AV, Picht E, Bers DM, Blatter LA. Partial inhibition of sarcoplasmic reticulum Ca release evokes long-lasting Ca release events in ventricular myocytes: Role of luminal Ca in termination of Ca release Biophysical Journal. 94: 1867-1879. PMID 18024505 DOI: 10.1529/Biophysj.107.114694  0.547
2008 Bers DM. Calcium cycling and signaling in cardiac myocytes Annual Review of Physiology. 70: 23-49. PMID 17988210 DOI: 10.1146/Annurev.Physiol.70.113006.100455  0.572
2008 Grandi E, Wang F, Bers DM. Na diffusion dependent ca handling in rabbit ventricular myocytes Computers in Cardiology. 35: 185-188. DOI: 10.1109/CIC.2008.4749008  0.441
2008 Pogwizd SM, Bers DM. Rabbit models of heart disease Drug Discovery Today: Disease Models. 5: 185-193. DOI: 10.1016/J.Ddmod.2009.02.001  0.324
2007 Kranias EG, Bers DM. Calcium and cardiomyopathies Sub-Cellular Biochemistry. 45: 523-537. PMID 18193651 DOI: 10.1007/978-1-4020-6191-2_20  0.583
2007 Zhang T, Kohlhaas M, Backs J, Mishra S, Phillips W, Dybkova N, Chang S, Ling H, Bers DM, Maier LS, Olson EN, Brown JH. CaMKIIdelta isoforms differentially affect calcium handling but similarly regulate HDAC/MEF2 transcriptional responses. The Journal of Biological Chemistry. 282: 35078-87. PMID 17923476 DOI: 10.1074/Jbc.M707083200  0.494
2007 Guo T, Ai X, Shannon TR, Pogwizd SM, Bers DM. Intra-sarcoplasmic reticulum free [Ca2+] and buffering in arrhythmogenic failing rabbit heart. Circulation Research. 101: 802-10. PMID 17704210 DOI: 10.1161/Circresaha.107.152140  0.64
2007 Grandi E, Puglisi JL, Wagner S, Maier LS, Severi S, Bers DM. Simulation of Ca-calmodulin-dependent protein kinase II on rabbit ventricular myocyte ion currents and action potentials. Biophysical Journal. 93: 3835-47. PMID 17704163 DOI: 10.1529/Biophysj.107.114868  0.558
2007 Bers DM. Going to cAMP just got more complicated Journal of Physiology. 583: 415-416. PMID 17656427 DOI: 10.1113/Jphysiol.2007.140764  0.559
2007 Altamirano J, Bers DM. Voltage dependence of cardiac excitation-contraction coupling: unitary Ca2+ current amplitude and open channel probability. Circulation Research. 101: 590-7. PMID 17641229 DOI: 10.1161/Circresaha.107.152322  0.728
2007 Altamirano J, Bers DM. Effect of intracellular Ca2+ and action potential duration on L-type Ca2+ channel inactivation and recovery from inactivation in rabbit cardiac myocytes. American Journal of Physiology. Heart and Circulatory Physiology. 293: H563-73. PMID 17400724 DOI: 10.1152/Ajpheart.00469.2006  0.751
2007 Despa S, Bers DM. Functional analysis of Na+/K+-ATPase isoform distribution in rat ventricular myocytes American Journal of Physiology - Cell Physiology. 293: C321-C327. PMID 17392375 DOI: 10.1152/Ajpcell.00597.2006  0.347
2007 Picht E, Zima AV, Blatter LA, Bers DM. SparkMaster: Automated calcium spark analysis with ImageJ American Journal of Physiology - Cell Physiology. 293: C1073-C1081. PMID 17376815 DOI: 10.1152/Ajpcell.00586.2006  0.427
2007 Bers DM, Ginsburg KS. Na:Ca stoichiometry and cytosolic Ca-dependent activation of NCX in intact cardiomyocytes Annals of the New York Academy of Sciences. 1099: 326-338. PMID 17303827 DOI: 10.1196/Annals.1387.060  0.583
2007 Islamovic E, Duncan A, Bers DM, Gerthoffer WT, Mestril R. Importance of small heat shock protein 20 (hsp20) C-terminal extension in cardioprotection Journal of Molecular and Cellular Cardiology. 42: 862-869. PMID 17292395 DOI: 10.1016/J.Yjmcc.2007.01.002  0.31
2007 Maier LS, Bers DM, Brown JH. Calmodulin and Ca2+/calmodulin kinases in the heart - physiology and pathophysiology. Cardiovascular Research. 73: 629-30. PMID 17258179 DOI: 10.1016/J.Cardiores.2007.01.005  0.417
2007 Huke S, Bers DM. Temporal dissociation of frequency-dependent acceleration of relaxation and protein phosphorylation by CaMKII Journal of Molecular and Cellular Cardiology. 42: 590-599. PMID 17239900 DOI: 10.1016/J.Yjmcc.2006.12.007  0.515
2007 Curran J, Hinton MJ, Ríos E, Bers DM, Shannon TR. β-adrenergic enhancement of sarcoplasmic reticulum calcium leak in cardiac myocytes is mediated by calcium/calmodulin-dependent protein kinase Circulation Research. 100: 391-398. PMID 17234966 DOI: 10.1161/01.Res.0000258172.74570.E6  0.576
2007 Yuan Q, Fan GC, Dong M, Altschafl B, Diwan A, Ren X, Hahn HH, Zhao W, Waggoner JR, Jones LR, Jones WK, Bers DM, Dorn GW, Wang HS, Valdivia HH, et al. Sarcoplasmic reticulum calcium overloading in junctin deficiency enhances cardiac contractility but increases ventricular automaticity. Circulation. 115: 300-9. PMID 17224479 DOI: 10.1161/Circulationaha.106.654699  0.589
2007 Berry RG, Despa S, Fuller W, Bers DM, Shattock MJ. Differential distribution and regulation of mouse cardiac Na+/K+-ATPase alpha1 and alpha2 subunits in T-tubule and surface sarcolemmal membranes. Cardiovascular Research. 73: 92-100. PMID 17157829 DOI: 10.1016/J.Cardiores.2006.11.006  0.77
2007 Maier LS, Bers DM. Role of Ca2+/calmodulin-dependent protein kinase (CaMK) in excitation-contraction coupling in the heart Cardiovascular Research. 73: 631-640. PMID 17157285 DOI: 10.1016/J.Cardiores.2006.11.005  0.593
2007 Tocchetti CG, Wang W, Froehlich JP, Huke S, Aon MA, Wilson GM, Di Benedetto G, O'Rourke B, Gao WD, Wink DA, Toscano JP, Zaccolo M, Bers DM, Valdivia HH, Cheng H, et al. Nitroxyl improves cellular heart function by directly enhancing cardiac sarcoplasmic reticulum Ca2+ cycling. Circulation Research. 100: 96-104. PMID 17138943 DOI: 10.1161/01.Res.0000253904.53601.C9  0.597
2007 Picht E, DeSantiago J, Huke S, Kaetzel MA, Dedman JR, Bers DM. CaMKII inhibition targeted to the sarcoplasmic reticulum inhibits frequency-dependent acceleration of relaxation and Ca2+ current facilitation Journal of Molecular and Cellular Cardiology. 42: 196-205. PMID 17052727 DOI: 10.1016/J.Yjmcc.2006.09.007  0.582
2007 Wu X, Bers DM. Free and bound intracellular calmodulin measurements in cardiac myocytes. Cell Calcium. 41: 353-64. PMID 16999996 DOI: 10.1016/J.Ceca.2006.07.011  0.632
2006 Bers DM, Despa S, Bossuyt J. Regulation of Ca2+ and Na+ in normal and failing cardiac myocytes Annals of the New York Academy of Sciences. 1080: 165-177. PMID 17132783 DOI: 10.1196/Annals.1380.015  0.616
2006 Wagner S, Dybkova N, Rasenack ECL, Jacobshagen C, Fabritz L, Kirchhof P, Maier SKG, Zhang T, Hasenfuss G, Brown JH, Bers DM, Maier LS. Ca2+/calmodulin-dependent protein kinase II regulates cardiac Na+ channels Journal of Clinical Investigation. 116: 3127-3138. PMID 17124532 DOI: 10.1172/Jci26620  0.489
2006 Bers DM. Altered cardiac myocyte Ca regulation in heart failure Physiology. 21: 380-387. PMID 17119150 DOI: 10.1152/Physiol.00019.2006  0.529
2006 Han F, Bossuyt J, Despa S, Tucker AL, Bers DM. Phospholemman phosphorylation mediates the protein kinase C-dependent effects on Na+/K+ pump function in cardiac myocytes. Circulation Research. 99: 1376-83. PMID 17095720 DOI: 10.1161/01.Res.0000251667.73461.Fb  0.52
2006 Bers DM. The beat goes on: Diastolic noise that just won't quit Circulation Research. 99: 921-923. PMID 17068299 DOI: 10.1161/01.Res.0000249859.10103.A9  0.576
2006 Picht E, DeSantiago J, Blatter LA, Bers DM. Cardiac alternans do not rely on diastolic sarcoplasmic reticulum calcium content fluctuations Circulation Research. 99: 740-748. PMID 16946134 DOI: 10.1161/01.Res.0000244002.88813.91  0.563
2006 Bossuyt J, Despa S, Martin JL, Bers DM. Phospholemman phosphorylation alters its fluorescence resonance energy transfer with the Na/K-ATPase pump Journal of Biological Chemistry. 281: 32765-32773. PMID 16943195 DOI: 10.1074/Jbc.M606254200  0.384
2006 Guo T, Zhang T, Mestril R, Bers DM. Ca2+/Calmodulin-dependent protein kinase II phosphorylation of ryanodine receptor does affect calcium sparks in mouse ventricular myocytes. Circulation Research. 99: 398-406. PMID 16840718 DOI: 10.1161/01.Res.0000236756.06252.13  0.662
2006 Altamirano J, Li Y, DeSantiago J, Piacentino V, Houser SR, Bers DM. The inotropic effect of cardioactive glycosides in ventricular myocytes requires Na+-Ca2+ exchanger function. The Journal of Physiology. 575: 845-54. PMID 16825310 DOI: 10.1113/Jphysiol.2006.111252  0.804
2006 Wu X, Bers DM. Sarcoplasmic reticulum and nuclear envelope are one highly interconnected Ca2+ store throughout cardiac myocyte. Circulation Research. 99: 283-91. PMID 16794184 DOI: 10.1161/01.Res.0000233386.02708.72  0.66
2006 Maier LS, Ziolo MT, Bossuyt J, Persechini A, Mestril R, Bers DM. Dynamic changes in free Ca-calmodulin levels in adult cardiac myocytes Journal of Molecular and Cellular Cardiology. 41: 451-458. PMID 16765983 DOI: 10.1016/J.Yjmcc.2006.04.020  0.572
2006 Bers DM. Cardiac ryanodine receptor phosphorylation: target sites and functional consequences. The Biochemical Journal. 396: e1-3. PMID 16626281 DOI: 10.1042/Bj20060377  0.477
2006 Gregory KN, Ginsburg KS, Bodi I, Hahn H, Marreez YM, Song Q, Padmanabhan PA, Mitton BA, Waggoner JR, Del Monte F, Park WJ, Dorn GW, Bers DM, Kranias EG. Histidine-rich Ca binding protein: a regulator of sarcoplasmic reticulum calcium sequestration and cardiac function. Journal of Molecular and Cellular Cardiology. 40: 653-65. PMID 16600288 DOI: 10.1016/J.Yjmcc.2006.02.003  0.607
2006 Bers DM, Despa S. Cardiac myocytes Ca2+ and Na+ regulation in normal and failing hearts Journal of Pharmacological Sciences. 100: 315-322. PMID 16552170 DOI: 10.1254/Jphs.Cpj06001X  0.62
2006 Wu X, Zhang T, Bossuyt J, Li X, McKinsey TA, Dedman JR, Olson EN, Chen J, Brown JH, Bers DM. Local InsP3-dependent perinuclear Ca2+ signaling in cardiac myocyte excitation-transcription coupling. The Journal of Clinical Investigation. 116: 675-82. PMID 16511602 DOI: 10.1172/Jci27374  0.668
2006 Sun J, Picht E, Ginsburg KS, Bers DM, Steenbergen C, Murphy E. Hypercontractile female hearts exhibit increased S-nitrosylation of the L-type Ca2+ channel alpha1 subunit and reduced ischemia/reperfusion injury. Circulation Research. 98: 403-11. PMID 16397145 DOI: 10.1161/01.Res.0000202707.79018.0A  0.431
2006 Kohlhaas M, Zhang T, Seidler T, Zibrova D, Dybkova N, Steen A, Wagner S, Chen L, Brown JH, Bers DM, Maier LS. Increased sarcoplasmic reticulum calcium leak but unaltered contractility by acute CaMKII overexpression in isolated rabbit cardiac myocytes. Circulation Research. 98: 235-44. PMID 16373600 DOI: 10.1161/01.Res.0000200739.90811.9F  0.589
2006 Remus TP, Zima AV, Bossuyt J, Bare DJ, Martin JL, Blatter LA, Bers DM, Mignery GA. Biosensors to measure inositol 1,4,5-trisphosphate concentration in living cells with spatiotemporal resolution. The Journal of Biological Chemistry. 281: 608-16. PMID 16249182 DOI: 10.1074/Jbc.M509645200  0.35
2006 Ji Y, Zhao W, Li B, Desantiago J, Picht E, Kaetzel MA, Schultz Jel J, Kranias EG, Bers DM, Dedman JR. Targeted inhibition of sarcoplasmic reticulum CaMKII activity results in alterations of Ca2+ homeostasis and cardiac contractility. American Journal of Physiology. Heart and Circulatory Physiology. 290: H599-606. PMID 16143658 DOI: 10.1152/Ajpheart.00214.2005  0.6
2006 Berry RG, Fuller W, Despa S, Bers DM, Shattock MJ. Differential distribution of mouse cardiac Na/K ATPase α1 and α2-subunit function in T-tubule and surface sarcolemmal membranes Journal of Molecular and Cellular Cardiology. 40: 997. DOI: 10.1016/J.Yjmcc.2006.03.226  0.574
2005 Ai X, Curran JW, Shannon TR, Bers DM, Pogwizd SM. Ca2+/calmodulin-dependent protein kinase modulates cardiac ryanodine receptor phosphorylation and sarcoplasmic reticulum Ca2+ leak in heart failure. Circulation Research. 97: 1314-22. PMID 16269653 DOI: 10.1161/01.Res.0000194329.41863.89  0.597
2005 Ginsburg KS, Bers DM. Isoproterenol does not enhance Ca-dependent Na/Ca exchange current in intact rabbit ventricular myocytes. Journal of Molecular and Cellular Cardiology. 39: 972-81. PMID 16242149 DOI: 10.1016/J.Yjmcc.2005.09.005  0.619
2005 Brette F, Despa S, Bers DM, Orchard CH. Spatiotemporal characteristics of SR Ca2+ uptake and release in detubulated rat ventricular myocytes Journal of Molecular and Cellular Cardiology. 39: 804-812. PMID 16198369 DOI: 10.1016/J.Yjmcc.2005.08.005  0.55
2005 Shannon TR, Wang F, Bers DM. Regulation of cardiac sarcoplasmic reticulum Ca release by luminal [Ca] and altered gating assessed with a mathematical model. Biophysical Journal. 89: 4096-110. PMID 16169970 DOI: 10.1529/Biophysj.105.068734  0.587
2005 Shannon TR, Bers DM, Blatter LA, Niggli E. Confocal imaging of CICR events from isolated and immobilized SR vesicles. Cell Calcium. 38: 497-505. PMID 16122794 DOI: 10.1016/J.Ceca.2005.07.002  0.55
2005 Bossuyt J, Ai X, Moorman JR, Pogwizd SM, Bers DM. Expression and phosphorylation of the na-pump regulatory subunit phospholemman in heart failure. Circulation Research. 97: 558-65. PMID 16100047 DOI: 10.1161/01.Res.0000181172.27931.C3  0.468
2005 Bers DM, Guo T. Calcium signaling in cardiac ventricular myocytes. Annals of the New York Academy of Sciences. 1047: 86-98. PMID 16093487 DOI: 10.1196/Annals.1341.008  0.647
2005 Despa S, Bossuyt J, Han F, Ginsburg KS, Jia LG, Kutchai H, Tucker AL, Bers DM. Phospholemman-phosphorylation mediates the beta-adrenergic effects on Na/K pump function in cardiac myocytes. Circulation Research. 97: 252-9. PMID 16002746 DOI: 10.1161/01.Res.0000176532.97731.E5  0.605
2005 Sanbe A, James J, Tuzcu V, Nas S, Martin L, Gulick J, Osinska H, Sakthivel S, Klevitsky R, Ginsburg KS, Bers DM, Zinman B, Lakatta EG, Robbins J. Transgenic rabbit model for human troponin I-based hypertrophic cardiomyopathy. Circulation. 111: 2330-8. PMID 15867176 DOI: 10.1161/01.Cir.0000164234.24957.75  0.483
2005 Bers DM. Beyond beta blockers. Nature Medicine. 11: 379-80. PMID 15812516 DOI: 10.1038/Nm0405-379  0.356
2005 Ziolo MT, Martin JL, Bossuyt J, Bers DM, Pogwizd SM. Adenoviral gene transfer of mutant phospholamban rescues contractile dysfunction in failing rabbit myocytes with relatively preserved SERCA function. Circulation Research. 96: 815-7. PMID 15790952 DOI: 10.1161/01.Res.0000163981.97262.3B  0.557
2005 Bare DJ, Kettlun CS, Liang M, Bers DM, Mignery GA. Cardiac type 2 inositol 1,4,5-trisphosphate receptor: interaction and modulation by calcium/calmodulin-dependent protein kinase II. The Journal of Biological Chemistry. 280: 15912-20. PMID 15710625 DOI: 10.1074/Jbc.M414212200  0.358
2005 Despa S, Kockskämper J, Blatter LA, Bers DM. Na/K pump-induced [Na](i) gradients in rat ventricular myocytes measured with two-photon microscopy. Biophysical Journal. 87: 1360-8. PMID 15298938 DOI: 10.1529/Biophysj.103.037895  0.433
2005 Bers DM. Macromolecular complexes regulating cardiac ryanodine receptor function. Journal of Molecular and Cellular Cardiology. 37: 417-29. PMID 15276012 DOI: 10.1016/J.Yjmcc.2004.05.026  0.485
2004 Teucher N, Prestle J, Seidler T, Currie S, Elliott EB, Reynolds DF, Schott P, Wagner S, Kogler H, Inesi G, Bers DM, Hasenfuss G, Smith GL. Excessive sarcoplasmic/endoplasmic reticulum Ca2+-ATPase expression causes increased sarcoplasmic reticulum Ca2+ uptake but decreases myocyte shortening. Circulation. 110: 3553-9. PMID 15505097 DOI: 10.1161/01.Cir.0000145161.48545.B3  0.566
2004 Shannon TR, Wang F, Puglisi J, Weber C, Bers DM. A mathematical treatment of integrated Ca dynamics within the ventricular myocyte. Biophysical Journal. 87: 3351-71. PMID 15347581 DOI: 10.1529/Biophysj.104.047449  0.721
2004 Chaudhary KW, Rossman EI, Piacentino V, Kenessey A, Weber C, Gaughan JP, Ojamaa K, Klein I, Bers DM, Houser SR, Margulies KB. Altered myocardial Ca2+ cycling after left ventricular assist device support in the failing human heart. Journal of the American College of Cardiology. 44: 837-45. PMID 15312868 DOI: 10.1016/J.Jacc.2004.05.049  0.681
2004 Bassani RA, Altamirano J, Puglisi JL, Bers DM. Action potential duration determines sarcoplasmic reticulum Ca2+ reloading in mammalian ventricular myocytes. The Journal of Physiology. 559: 593-609. PMID 15243136 DOI: 10.1113/Jphysiol.2004.067959  0.7
2004 Shannon TR, Bers DM. Integrated Ca2+ management in cardiac myocytes. Annals of the New York Academy of Sciences. 1015: 28-38. PMID 15201147 DOI: 10.1196/Annals.1302.003  0.581
2004 Ziolo MT, Maier LS, Piacentino V, Bossuyt J, Houser SR, Bers DM. Myocyte nitric oxide synthase 2 contributes to blunted beta-adrenergic response in failing human hearts by decreasing Ca2+ transients. Circulation. 109: 1886-91. PMID 15037528 DOI: 10.1161/01.Cir.0000124231.98250.A8  0.395
2004 Pogwizd SM, Bers DM. Cellular basis of triggered arrhythmias in heart failure. Trends in Cardiovascular Medicine. 14: 61-6. PMID 15030791 DOI: 10.1016/J.Tcm.2003.12.002  0.496
2004 DeSantiago J, Maier LS, Bers DM. Phospholamban is required for CaMKII-dependent recovery of Ca transients and SR Ca reuptake during acidosis in cardiac myocytes. Journal of Molecular and Cellular Cardiology. 36: 67-74. PMID 14734049 DOI: 10.1016/J.Yjmcc.2003.10.012  0.568
2004 Ginsburg KS, Bers DM. Modulation of excitation-contraction coupling by isoproterenol in cardiomyocytes with controlled SR Ca2+ load and Ca2+ current trigger. The Journal of Physiology. 556: 463-80. PMID 14724205 DOI: 10.1113/Jphysiol.2003.055384  0.553
2004 Lipsius SL, Bers DM. Cardiac pacemaking: I(f) vs. Ca(2+), is it really that simple? Journal of Molecular and Cellular Cardiology. 35: 891-3. PMID 12878475 DOI: 10.1016/S0022-2828(03)00184-6  0.499
2004 Despa S, Bers DM. Na/K pump current and [Na](i) in rabbit ventricular myocytes: local [Na](i) depletion and Na buffering. Biophysical Journal. 84: 4157-66. PMID 12770918 DOI: 10.1016/S0006-3495(03)75140-6  0.363
2003 Despa S, Brette F, Orchard CH, Bers DM. Na/Ca Exchange and Na/K-ATPase Function Are Equally Concentrated in Transverse Tubules of Rat Ventricular Myocytes Biophysical Journal. 85: 3388-3396. PMID 14581240 DOI: 10.1016/S0006-3495(03)74758-4  0.421
2003 Weber CR, Piacentino V, Houser SR, Bers DM. Dynamic regulation of sodium/calcium exchange function in human heart failure. Circulation. 108: 2224-9. PMID 14557358 DOI: 10.1161/01.Cir.0000095274.72486.94  0.739
2003 Bers DM, Eisner DA, Valdivia HH. Sarcoplasmic reticulum Ca2+ and heart failure: roles of diastolic leak and Ca2+ transport. Circulation Research. 93: 487-90. PMID 14500331 DOI: 10.1161/01.Res.0000091871.54907.6B  0.577
2003 Shannon TR, Pogwizd SM, Bers DM. Elevated sarcoplasmic reticulum Ca2+ leak in intact ventricular myocytes from rabbits in heart failure. Circulation Research. 93: 592-4. PMID 12946948 DOI: 10.1161/01.Res.0000093399.11734.B3  0.574
2003 Kirchhefer U, Neumann J, Bers DM, Buchwalow IB, Fabritz L, Hanske G, Justus I, Riemann B, Schmitz W, Jones LR. Impaired relaxation in transgenic mice overexpressing junctin. Cardiovascular Research. 59: 369-79. PMID 12909320 DOI: 10.1016/S0008-6363(03)00432-2  0.516
2003 Ziolo MT, Bers DM. The real estate of NOS signaling: location, location, location. Circulation Research. 92: 1279-81. PMID 12829613 DOI: 10.1161/01.Res.0000080783.34092.Af  0.592
2003 Shannon TR, Guo T, Bers DM. Ca2+ scraps: local depletions of free [Ca2+] in cardiac sarcoplasmic reticulum during contractions leave substantial Ca2+ reserve. Circulation Research. 93: 40-5. PMID 12791706 DOI: 10.1161/01.Res.0000079967.11815.19  0.666
2003 Weber CR, Ginsburg KS, Bers DM. Cardiac submembrane [Na+] transients sensed by Na+-Ca2+ exchange current. Circulation Research. 92: 950-2. PMID 12702644 DOI: 10.1161/01.Res.0000071747.61468.7F  0.7
2003 Bers DM. Dynamic imaging in living cells: windows into local signaling. Science's Stke : Signal Transduction Knowledge Environment. 2003: PE13. PMID 12684526 DOI: 10.1126/Stke.2003.177.Pe13  0.544
2003 Zhang T, Maier LS, Dalton ND, Miyamoto S, Ross J, Bers DM, Brown JH. The deltaC isoform of CaMKII is activated in cardiac hypertrophy and induces dilated cardiomyopathy and heart failure. Circulation Research. 92: 912-9. PMID 12676814 DOI: 10.1161/01.Res.0000069686.31472.C5  0.513
2003 Maier LS, Zhang T, Chen L, DeSantiago J, Brown JH, Bers DM. Transgenic CaMKIIdeltaC overexpression uniquely alters cardiac myocyte Ca2+ handling: reduced SR Ca2+ load and activated SR Ca2+ release. Circulation Research. 92: 904-11. PMID 12676813 DOI: 10.1161/01.Res.0000069685.20258.F1  0.596
2003 von Lewinski D, Stumme B, Maier LS, Luers C, Bers DM, Pieske B. Stretch-dependent slow force response in isolated rabbit myocardium is Na+ dependent. Cardiovascular Research. 57: 1052-61. PMID 12650883 DOI: 10.1016/S0008-6363(02)00830-1  0.302
2003 Bers DM, Barry WH, Despa S. Intracellular Na+ regulation in cardiac myocytes. Cardiovascular Research. 57: 897-912. PMID 12650868 DOI: 10.1016/S0008-6363(02)00656-9  0.461
2003 Pogwizd SM, Sipido KR, Verdonck F, Bers DM. Intracellular Na in animal models of hypertrophy and heart failure: contractile function and arrhythmogenesis. Cardiovascular Research. 57: 887-96. PMID 12650867 DOI: 10.1016/S0008-6363(02)00735-6  0.564
2003 Pieske B, Houser SR, Hasenfuss G, Bers DM. Sodium and the heart: a hidden key factor in cardiac regulation. Cardiovascular Research. 57: 871-2. PMID 12650864 DOI: 10.1016/S0008-6363(02)00849-0  0.522
2003 Brittsan AG, Ginsburg KS, Chu G, Yatani A, Wolska BM, Schmidt AG, Asahi M, MacLennan DH, Bers DM, Kranias EG. Chronic SR Ca2+-ATPase inhibition causes adaptive changes in cellular Ca2+ transport. Circulation Research. 92: 769-76. PMID 12637367 DOI: 10.1161/01.Res.0000066661.49920.59  0.585
2003 Piacentino V, Weber CR, Chen X, Weisser-Thomas J, Margulies KB, Bers DM, Houser SR. Cellular basis of abnormal calcium transients of failing human ventricular myocytes. Circulation Research. 92: 651-8. PMID 12600875 DOI: 10.1161/01.Res.0000062469.83985.9B  0.723
2003 Pogwizd SM, Bers DM. Na/Ca exchange in heart failure: contractile dysfunction and arrhythmogenesis. Annals of the New York Academy of Sciences. 976: 454-65. PMID 12502595 DOI: 10.1111/J.1749-6632.2002.Tb04775.X  0.604
2003 DeSantiago J, Maier LS, Bers DM. Frequency-dependent acceleration of relaxation in the heart depends on CaMKII, but not phospholamban. Journal of Molecular and Cellular Cardiology. 34: 975-84. PMID 12234767 DOI: 10.1006/Jmcc.2002.2034  0.57
2003 Maier LS, Bers DM. Calcium, calmodulin, and calcium-calmodulin kinase II: heartbeat to heartbeat and beyond. Journal of Molecular and Cellular Cardiology. 34: 919-39. PMID 12234763 DOI: 10.1006/Jmcc.2002.2038  0.574
2003 Brandes R, Bers DM. Simultaneous measurements of mitochondrial NADH and Ca(2+) during increased work in intact rat heart trabeculae. Biophysical Journal. 83: 587-604. PMID 12124250 DOI: 10.1016/S0006-3495(02)75194-1  0.518
2002 Bers DM, Weber CR. Na/Ca exchange function in intact ventricular myocytes. Annals of the New York Academy of Sciences. 976: 500-12. PMID 12502604 DOI: 10.1111/J.1749-6632.2002.Tb04784.X  0.723
2002 Weber CR, Piacentino V, Margulies KB, Bers DM, Houser SR. Calcium influx via I(NCX) is favored in failing human ventricular myocytes. Annals of the New York Academy of Sciences. 976: 478-9. PMID 12502599 DOI: 10.1111/J.1749-6632.2002.Tb04779.X  0.557
2002 Piacentino V, Weber CR, Gaughan JP, Margulies KB, Bers DM, Houser SR. Modulation of contractility in failing human myocytes by reverse-mode Na/Ca exchange. Annals of the New York Academy of Sciences. 976: 466-71. PMID 12502596 DOI: 10.1111/J.1749-6632.2002.Tb04776.X  0.729
2002 Ginsburg KS, Weber CR, Despa S, Bers DM. Simultaneous measurement of [Na]i, [Ca]i, and I(NCX) in intact cardiac myocytes. Annals of the New York Academy of Sciences. 976: 157-8. PMID 12502556 DOI: 10.1111/J.1749-6632.2002.Tb04736.X  0.721
2002 Bers DM, Pogwizd SM, Schlotthauer K. Upregulated Na/Ca exchange is involved in both contractile dysfunction and arrhythmogenesis in heart failure. Basic Research in Cardiology. I36-42. PMID 12479232 DOI: 10.1007/S003950200027  0.589
2002 Zhou Z, Bers DM. Time course of action of antagonists of mitochondrial Ca uptake in intact ventricular myocytes. PflüGers Archiv : European Journal of Physiology. 445: 132-8. PMID 12397397 DOI: 10.1007/S00424-002-0909-7  0.545
2002 Shannon TR, Ginsburg KS, Bers DM. Quantitative assessment of the SR Ca2+ leak-load relationship. Circulation Research. 91: 594-600. PMID 12364387 DOI: 10.1161/01.Res.0000036914.12686.28  0.577
2002 Bers DM. Sarcoplasmic reticulum Ca release in intact ventricular myocytes. Frontiers in Bioscience : a Journal and Virtual Library. 7: d1697-711. PMID 12086924 DOI: 10.2741/A873  0.466
2002 Bers DM. Sarcoplasmic reticulum Ca release in intact ventricular myocytes. Frontiers in Bioscience : a Journal and Virtual Library. 7: d1697-711. PMID 12086924 DOI: 10.2741/A873  0.466
2002 Despa S, Islam MA, Weber CR, Pogwizd SM, Bers DM. Intracellular Na(+) concentration is elevated in heart failure but Na/K pump function is unchanged. Circulation. 105: 2543-8. PMID 12034663 DOI: 10.1161/01.Cir.0000016701.85760.97  0.671
2002 Bers DM. Cardiac Na/Ca exchange function in rabbit, mouse and man: what's the difference? Journal of Molecular and Cellular Cardiology. 34: 369-73. PMID 11991726 DOI: 10.1006/Jmcc.2002.1530  0.553
2002 Li Y, Kranias EG, Mignery GA, Bers DM. Protein kinase A phosphorylation of the ryanodine receptor does not affect calcium sparks in mouse ventricular myocytes. Circulation Research. 90: 309-16. PMID 11861420 DOI: 10.1161/Hh0302.105660  0.717
2002 Despa S, Islam MA, Pogwizd SM, Bers DM. Intracellular [Na+] and Na+ pump rate in rat and rabbit ventricular myocytes. The Journal of Physiology. 539: 133-43. PMID 11850507 DOI: 10.1113/Jphysiol.2001.012940  0.406
2002 Pogwizd SM, Bers DM. Calcium cycling in heart failure: the arrhythmia connection. Journal of Cardiovascular Electrophysiology. 13: 88-91. PMID 11843491 DOI: 10.1046/J.1540-8167.2002.00088.X  0.576
2002 Weber CR, Piacentino V, Ginsburg KS, Houser SR, Bers DM. Na(+)-Ca(2+) exchange current and submembrane [Ca(2+)] during the cardiac action potential. Circulation Research. 90: 182-9. PMID 11834711 DOI: 10.1161/Hh0202.103940  0.719
2002 Bers DM. Cardiac excitation-contraction coupling. Nature. 415: 198-205. PMID 11805843 DOI: 10.1038/415198A  0.365
2002 Ziolo MT, Katoh H, Bers DM. Expression of inducible nitric oxide synthase depresses beta-adrenergic-stimulated calcium release from the sarcoplasmic reticulum in intact ventricular myocytes. Circulation. 104: 2961-6. PMID 11739313 DOI: 10.1161/Hc4901.100379  0.359
2002 Ziolo MT, Katoh H, Bers DM. Positive and negative effects of nitric oxide on Ca(2+) sparks: influence of beta-adrenergic stimulation. American Journal of Physiology. Heart and Circulatory Physiology. 281: H2295-303. PMID 11709395 DOI: 10.1152/Ajpheart.2001.281.6.H2295  0.466
2002 Bers DM. Calcium and Cardiac Rhythms Circulation Research. 90: 14-17. DOI: 10.1161/Res.90.1.14  0.594
2001 Li Y, Bers DM. A cardiac dihydropyridine receptor II-III loop peptide inhibits resting Ca(2+) sparks in ferret ventricular myocytes. The Journal of Physiology. 537: 17-26. PMID 11711557 DOI: 10.1111/J.1469-7793.2001.0017K.X  0.703
2001 Puglisi JL, Bers DM. LabHEART: an interactive computer model of rabbit ventricular myocyte ion channels and Ca transport. American Journal of Physiology. Cell Physiology. 281: C2049-60. PMID 11698264 DOI: 10.1152/Ajpcell.2001.281.6.C2049  0.566
2001 Pogwizd SM, Schlotthauer K, Li L, Yuan W, Bers DM. Arrhythmogenesis and contractile dysfunction in heart failure: Roles of sodium-calcium exchange, inward rectifier potassium current, and residual beta-adrenergic responsiveness. Circulation Research. 88: 1159-67. PMID 11397782 DOI: 10.1161/Hh1101.091193  0.539
2001 Weber CR, Ginsburg KS, Philipson KD, Shannon TR, Bers DM. Allosteric regulation of Na/Ca exchange current by cytosolic Ca in intact cardiac myocytes. The Journal of General Physiology. 117: 119-31. PMID 11158165 DOI: 10.1085/Jgp.117.2.119  0.73
2001 Maier LS, Bers DM, Pieske B. Differences in Ca(2+)-handling and sarcoplasmic reticulum Ca(2+)-content in isolated rat and rabbit myocardium. Journal of Molecular and Cellular Cardiology. 32: 2249-58. PMID 11113000 DOI: 10.1006/Jmcc.2000.1252  0.498
2001 Bers DM, Ziolo MT. When Is cAMP Not cAMP? Circulation Research. 89: 373-375. DOI: 10.1161/Res.89.5.373  0.501
2000 Shannon TR, Chu G, Kranias EG, Bers DM. Phospholamban decreases the energetic efficiency of the sarcoplasmic reticulum Ca pump. The Journal of Biological Chemistry. 276: 7195-201. PMID 11087739 DOI: 10.1074/Jbc.M007085200  0.562
2000 Frank K, Tilgmann C, Shannon TR, Bers DM, Kranias EG. Regulatory role of phospholamban in the efficiency of cardiac sarcoplasmic reticulum Ca2+ transport. Biochemistry. 39: 14176-82. PMID 11087366 DOI: 10.1021/Bi001049K  0.59
2000 Schlotthauer K, Bers DM. Sarcoplasmic reticulum Ca(2+) release causes myocyte depolarization. Underlying mechanism and threshold for triggered action potentials. Circulation Research. 87: 774-80. PMID 11055981 DOI: 10.1161/01.Res.87.9.774  0.571
2000 Bers DM. Calcium fluxes involved in control of cardiac myocyte contraction. Circulation Research. 87: 275-81. PMID 10948060 DOI: 10.1161/01.Res.87.4.275  0.604
2000 Katoh H, Schlotthauer K, Bers DM. Transmission of information from cardiac dihydropyridine receptor to ryanodine receptor: evidence from BayK 8644 effects on resting Ca(2+) sparks. Circulation Research. 87: 106-11. PMID 10903993 DOI: 10.1161/01.Res.87.2.106  0.571
2000 Satoh H, Ginsburg KS, Qing K, Terada H, Hayashi H, Bers DM. KB-R7943 block of Ca(2+) influx via Na(+)/Ca(2+) exchange does not alter twitches or glycoside inotropy but prevents Ca(2+) overload in rat ventricular myocytes. Circulation. 101: 1441-6. PMID 10736290 DOI: 10.1161/01.Cir.101.12.1441  0.585
2000 Li L, Desantiago J, Chu G, Kranias EG, Bers DM. Phosphorylation of phospholamban and troponin I in beta-adrenergic-induced acceleration of cardiac relaxation. American Journal of Physiology. Heart and Circulatory Physiology. 278: H769-79. PMID 10710345 DOI: 10.1152/Ajpheart.2000.278.3.H769  0.47
2000 Zhou Z, Bers DM. Ca2+ influx via the L-type Ca2+ channel during tail current and above current reversal potential in ferret ventricular myocytes Journal of Physiology. 523: 57-66. PMID 10673545 DOI: 10.1111/J.1469-7793.2000.T01-2-00057.X  0.563
2000 Shannon TR, Ginsburg KS, Bers DM. Potentiation of fractional sarcoplasmic reticulum calcium release by total and free intra-sarcoplasmic reticulum calcium concentration. Biophysical Journal. 78: 334-43. PMID 10620297 DOI: 10.1016/S0006-3495(00)76596-9  0.503
2000 Shannon TR, Ginsburg KS, Bers DM. Reverse mode of the sarcoplasmic reticulum calcium pump and load-dependent cytosolic calcium decline in voltage-clamped cardiac ventricular myocytes. Biophysical Journal. 78: 322-33. PMID 10620296 DOI: 10.1016/S0006-3495(00)76595-7  0.389
2000 Shannon TR, Ginsburg KS, Bers DM. Reverse mode of the sarcoplasmic reticulum Ca pump limits sarcoplasmic reticulum Ca uptake in permeabilized and voltage-clamped myocytes. Annals of the New York Academy of Sciences. 853: 350-2. PMID 10603977 DOI: 10.1111/J.1749-6632.1998.Tb08297.X  0.535
2000 Bers DM, Li L, Satoh H, McCall E. Factors that control sarcoplasmic reticulum calcium release in intact ventricular myocytes. Annals of the New York Academy of Sciences. 853: 157-77. PMID 10603944 DOI: 10.1111/J.1749-6632.1998.Tb08264.X  0.568
2000 Pogwizd SM, Qi M, Yuan W, Samarel AM, Bers DM. Upregulation of Na(+)/Ca(2+) exchanger expression and function in an arrhythmogenic rabbit model of heart failure. Circulation Research. 85: 1009-19. PMID 10571531 DOI: 10.1161/01.Res.85.11.1009  0.582
1999 Bers DM, Perez-Reyes E. Ca channels in cardiac myocytes: structure and function in Ca influx and intracellular Ca release. Cardiovascular Research. 42: 339-60. PMID 10533572 DOI: 10.1016/S0008-6363(99)00038-3  0.553
1999 Puglisi JL, Yuan W, Bassani JW, Bers DM. Ca(2+) influx through Ca(2+) channels in rabbit ventricular myocytes during action potential clamp: influence of temperature. Circulation Research. 85: e7-e16. PMID 10488061 DOI: 10.1161/01.Res.85.6.E7  0.556
1999 Haddock PS, Coetzee WA, Cho E, Porter L, Katoh H, Bers DM, Jafri MS, Artman M. Subcellular [Ca2+]i gradients during excitation-contraction coupling in newborn rabbit ventricular myocytes. Circulation Research. 85: 415-27. PMID 10473671 DOI: 10.1161/01.Res.85.5.415  0.564
1999 Brandes R, Bers DM. Analysis of the mechanisms of mitochondrial NADH regulation in cardiac trabeculae. Biophysical Journal. 77: 1666-82. PMID 10465777 DOI: 10.1016/S0006-3495(99)77014-1  0.504
1999 Pieske B, Maier LS, Bers DM, Hasenfuss G. Ca2+ handling and sarcoplasmic reticulum Ca2+ content in isolated failing and nonfailing human myocardium. Circulation Research. 85: 38-46. PMID 10400909 DOI: 10.1161/01.Res.85.1.38  0.547
1999 Cadre BM, Qi M, Eble DM, Shannon TR, Bers DM, Samarel AM. Cyclic stretch down-regulates calcium transporter gene expression in neonatal rat ventricular myocytes. Journal of Molecular and Cellular Cardiology. 30: 2247-59. PMID 9925362 DOI: 10.1006/Jmcc.1998.0788  0.563
1999 Bassani RA, Shannon TR, Bers DM. Passive Ca2+ binding in ventricular myocardium of neonatal and adult rats. Cell Calcium. 23: 433-42. PMID 9924635 DOI: 10.1016/S0143-4160(98)90100-2  0.523
1998 Hüser J, Bers DM, Blatter LA. Subcellular properties of [Ca]transients in phospholamban-deficient mouse ventricular cells. American Journal of Physiology. Heart and Circulatory Physiology. 274: H1800-H1811. PMID 29586507 DOI: 10.1152/Ajpheart.1998.274.5.H1800  0.56
1998 Li L, Chu G, Kranias EG, Bers DM. Cardiac myocyte calcium transport in phospholamban knockout mouse: relaxation and endogenous CaMKII effects. American Journal of Physiology. Heart and Circulatory Physiology. 274: H1335-H1347. PMID 29586013 DOI: 10.1152/Ajpheart.1998.274.4.H1335  0.59
1998 McCall E, Ginsburg KS, Bassani RA, Shannon TR, Qi M, Samarel AM, Bers DM. Ca flux, contractility, and excitation-contraction coupling in hypertrophic rat ventricular myocytes. American Journal of Physiology. Heart and Circulatory Physiology. 274: H1348-H1360. PMID 29585994 DOI: 10.1152/Ajpheart.1998.274.4.H1348  0.567
1998 Maier LS, Brandes R, Pieske B, Bers DM. Effects of left ventricular hypertrophy on force and Cahandling in isolated rat myocardium. American Journal of Physiology. Heart and Circulatory Physiology. 274: H1361-H1370. PMID 29585979 DOI: 10.1152/Ajpheart.1998.274.4.H1361  0.463
1998 Satoh H, Katoh H, Velez P, Fill M, Bers DM. Bay K 8644 increases resting Ca2+ spark frequency in ferret ventricular myocytes independent of Ca influx: Contrast with caffeine and ryanodine effects Circulation Research. 83: 1192-1204. PMID 9851936 DOI: 10.1161/01.Res.83.12.1192  0.57
1998 Chu G, Li L, Sato Y, Harrer JM, Kadambi VJ, Hoit BD, Bers DM, Kranias EG. Pentameric assembly of phospholamban facilitates inhibition of cardiac function in vivo. The Journal of Biological Chemistry. 273: 33674-80. PMID 9837953 DOI: 10.1074/Jbc.273.50.33674  0.481
1998 Schlotthauer K, Schattmann J, Bers DM, Maier LS, Schütt U, Minami K, Just H, Hasenfuss G, Pieske B. Frequency-dependent changes in contribution of SR Ca2+ to Ca2+ transients in failing human myocardium assessed with ryanodine. Journal of Molecular and Cellular Cardiology. 30: 1285-94. PMID 9710797 DOI: 10.1006/Jmcc.1998.0690  0.483
1998 Brandes R, Maier LS, Bers DM. Regulation of mitochondrial [NADH] by cytosolic [Ca2+] and work in trabeculae from hypertrophic and normal rat hearts. Circulation Research. 82: 1189-98. PMID 9633918 DOI: 10.1161/01.Res.82.11.1189  0.531
1998 Matlib MA, Zhou Z, Knight S, Ahmed S, Choi KM, Krause-Bauer J, Phillips R, Altschuld R, Katsube Y, Sperelakis N, Bers DM. Oxygen-bridged dinuclear ruthenium amine complex specifically inhibits Ca2+ uptake into mitochondria in vitro and in situ in single cardiac myocytes Journal of Biological Chemistry. 273: 10223-10231. PMID 9553073 DOI: 10.1074/Jbc.273.17.10223  0.567
1998 Ginsburg KS, Weber CR, Bers DM. Control of maximum sarcoplasmic reticulum Ca load in intact ferret ventricular myocytes. Effects Of thapsigargin and isoproterenol. The Journal of General Physiology. 111: 491-504. PMID 9524134 DOI: 10.1085/Jgp.111.4.491  0.721
1998 Zhou Z, Matlib MA, Bers DM. Cytosolic and mitochondrial Ca2+ signals in patch clamped mammalian ventricular myocytes The Journal of Physiology. 507: Pt 2/-. PMID 9518700 DOI: 10.1111/J.1469-7793.1998.379Bt.X  0.554
1998 Eble DM, Cadre BM, Qi M, Bers DM, Samarel AM. Contractile activity modulates atrial natriuretic factor gene expression in neonatal rat ventricular myocytes. Journal of Molecular and Cellular Cardiology. 30: 55-60. PMID 9500864 DOI: 10.1006/Jmcc.1997.0571  0.575
1997 Balaguru D, Haddock PS, Puglisi JL, Bers DM, Coetzee WA, Artman M. Role of the sarcoplasmic reticulum in contraction and relaxation of immature rabbit ventricular myocytes. Journal of Molecular and Cellular Cardiology. 29: 2747-57. PMID 9344769 DOI: 10.1006/Jmcc.1997.0509  0.553
1997 Shannon TR, Bers DM. Assessment of intra-SR free [Ca] and buffering in rat heart. Biophysical Journal. 73: 1524-31. PMID 9284319 DOI: 10.1016/S0006-3495(97)78184-0  0.569
1997 Bassani RA, Bassani JW, Lipsius SL, Bers DM. Diastolic SR Ca efflux in atrial pacemaker cells and Ca-overloaded myocytes. The American Journal of Physiology. 273: H886-92. PMID 9277507 DOI: 10.1152/Ajpheart.1997.273.2.H886  0.581
1997 Qi M, Puglisi JL, Byron KL, Ojamaa K, Klein I, Bers DM, Samarel AM. Myosin heavy chain gene expression in neonatal rat heart cells: effects of [Ca2+]i and contractile activity. The American Journal of Physiology. 273: C394-403. PMID 9277337 DOI: 10.1152/Ajpcell.1997.273.2.C394  0.451
1997 Bers DM. Ca transport during contraction and relaxation in mammalian ventricular muscle. Basic Research in Cardiology. 1-10. PMID 9202838 DOI: 10.1007/Bf00794062  0.59
1997 Delbridge LM, Satoh H, Yuan W, Bassani JW, Qi M, Ginsburg KS, Samarel AM, Bers DM. Cardiac myocyte volume, Ca2+ fluxes, and sarcoplasmic reticulum loading in pressure-overload hypertrophy. The American Journal of Physiology. 272: H2425-35. PMID 9176314 DOI: 10.1152/Ajpheart.1997.272.5.H2425  0.539
1997 Qi M, Shannon TR, Euler DE, Bers DM, Samarel AM. Downregulation of sarcoplasmic reticulum Ca(2+)-ATPase during progression of left ventricular hypertrophy. The American Journal of Physiology. 272: H2416-24. PMID 9176313 DOI: 10.1152/Ajpheart.1997.272.5.H2416  0.482
1997 Li L, Satoh H, Ginsburg KS, Bers DM. The effect of Ca(2+)-calmodulin-dependent protein kinase II on cardiac excitation-contraction coupling in ferret ventricular myocytes. The Journal of Physiology. 17-31. PMID 9174990 DOI: 10.1111/J.1469-7793.1997.017Bo.X  0.581
1997 Satoh H, Blatter LA, Bers DM. Effects of [Ca2+]i, SR Ca2+ load, and rest on Ca2+ spark frequency in ventricular myocytes. The American Journal of Physiology. 272: H657-68. PMID 9124422 DOI: 10.1152/Ajpheart.1997.272.2.H657  0.567
1997 Brandes R, Bers DM. Intracellular Ca2+ increases the mitochondrial NADH concentration during elevated work in intact cardiac muscle. Circulation Research. 80: 82-7. PMID 8978326 DOI: 10.1161/01.Res.80.1.82  0.515
1997 McCall E, Li L, Satoh H, Shannon TR, Blatter LA, Bers DM. Effects of FK-506 on contraction and Ca2+ transients in rat cardiac myocytes. Circulation Research. 79: 1110-21. PMID 8943949 DOI: 10.1161/01.Res.79.6.1110  0.589
1997 Brandes R, Bers DM. Increased work in cardiac trabeculae causes decreased mitochondrial NADH fluorescence followed by slow recovery. Biophysical Journal. 71: 1024-35. PMID 8842239 DOI: 10.1016/S0006-3495(96)79303-7  0.351
1996 Puglisi JL, Bassani RA, Bassani JW, Amin JN, Bers DM. Temperature and relative contributions of Ca transport systems in cardiac myocyte relaxation. The American Journal of Physiology. 270: H1772-8. PMID 8928885 DOI: 10.1152/Ajpheart.1996.270.5.H1772  0.574
1996 Gómez AM, Cheng H, Lederer WJ, Bers DM. Ca2+ diffusion and sarcoplasmic reticulum transport both contribute to [Ca2+]i decline during Ca2+ sparks in rat ventricular myocytes. The Journal of Physiology. 496: 575-81. PMID 8910239 DOI: 10.1113/Jphysiol.1996.Sp021708  0.558
1996 Qi M, Bassani JW, Bers DM, Samarel AM. Phorbol 12-myristate 13-acetate alters SR Ca(2+)-ATPase gene expression in cultured neonatal rat heart cells. The American Journal of Physiology. 271: H1031-9. PMID 8853338 DOI: 10.1152/Ajpheart.1996.271.3.H1031  0.541
1996 Yuan W, Ginsburg KS, Bers DM. Comparison of sarcolemmal calcium channel current in rabbit and rat ventricular myocytes. The Journal of Physiology. 733-46. PMID 8799895 DOI: 10.1113/Jphysiol.1996.Sp021418  0.468
1996 Delbridge LM, Bassani JW, Bers DM. Steady-state twitch Ca2+ fluxes and cytosolic Ca2+ buffering in rabbit ventricular myocytes. The American Journal of Physiology. 270: C192-9. PMID 8772444 DOI: 10.1152/Ajpcell.1996.270.1.C192  0.562
1996 McCall E, Hryshko LV, Stiffel VM, Christensen DM, Bers DM. Possible functional linkage between the cardiac dihydropyridine and ryanodine receptor: acceleration of rest decay by Bay K 8644. Journal of Molecular and Cellular Cardiology. 28: 79-93. PMID 8745216 DOI: 10.1006/Jmcc.1996.0008  0.522
1996 Bers DM, Bassani JW, Bassani RA. Na-Ca exchange and Ca fluxes during contraction and relaxation in mammalian ventricular muscle. Annals of the New York Academy of Sciences. 779: 430-42. PMID 8659859 DOI: 10.1111/J.1749-6632.1996.Tb44818.X  0.588
1996 McCall E, Bers DM. BAY K 8644 depresses excitation-contraction coupling in cardiac muscle. The American Journal of Physiology. 270: C878-84. PMID 8638669 DOI: 10.1152/Ajpcell.1996.270.3.C878  0.568
1996 Bassani RA, Bassani JW, Bers DM. Relaxation in ferret ventricular myocytes: role of the sarcolemmal Ca ATPase. Pflugers Archiv : European Journal of Physiology. 430: 573-8. PMID 7491284 DOI: 10.1007/Bf00373894  0.57
1995 Yuan W, Bers DM. Protein kinase inhibitor H-89 reverses forskolin stimulation of cardiac L- type calcium current American Journal of Physiology - Cell Physiology. 268. PMID 7900772 DOI: 10.1152/Ajpcell.1995.268.3.C651  0.521
1995 Bassani RA, Bers DM. Na-Ca exchange is required for rest-decay but not for rest-potentiation of twitches in rabbit and rat ventricular myocytes. Journal of Molecular and Cellular Cardiology. 26: 1335-47. PMID 7869394 DOI: 10.1006/Jmcc.1994.1152  0.572
1995 Bassani RA, Mattiazzi A, Bers DM. CaMKII is responsible for activity-dependent acceleration of relaxation in rat ventricular myocytes. The American Journal of Physiology. 268: H703-12. PMID 7864197 DOI: 10.1152/Ajpheart.1995.268.2.H703  0.564
1995 Bers DM, Berlin JR. Kinetics of [Ca](i) decline in cardiac myocytes depend on peak [Ca](i) American Journal of Physiology - Cell Physiology. 268. PMID 7840156 DOI: 10.1152/Ajpcell.1995.268.1.C271  0.566
1995 Berlin JR, Bassani JW, Bers DM. Intrinsic cytosolic calcium buffering properties of single rat cardiac myocytes. Biophysical Journal. 67: 1775-87. PMID 7819510 DOI: 10.1016/S0006-3495(94)80652-6  0.576
1995 Bassani JW, Bassani RA, Bers DM. Calibration of indo-1 and resting intracellular [Ca]i in intact rabbit cardiac myocytes. Biophysical Journal. 68: 1453-60. PMID 7787031 DOI: 10.1016/S0006-3495(95)80318-8  0.585
1995 Bassani JW, Yuan W, Bers DM. Fractional SR Ca release is regulated by trigger Ca and SR Ca content in cardiac myocytes. The American Journal of Physiology. 268: C1313-9. PMID 7762626 DOI: 10.1152/Ajpcell.1995.268.5.C1313  0.564
1995 Bassani RA, Bers DM. Rate of diastolic Ca release from the sarcoplasmic reticulum of intact rabbit and rat ventricular myocytes. Biophysical Journal. 68: 2015-22. PMID 7612843 DOI: 10.1016/S0006-3495(95)80378-4  0.575
1994 Bers DM, Bassani JW, Bassani RA. Competition and redistribution among calcium transport systems in rabbit cardiac myocytes. Cardiovascular Research. 27: 1772-7. PMID 8275522 DOI: 10.1093/Cvr/27.10.1772  0.531
1994 Bers DM, Patton CW, Nuccitelli R. Chapter 1 – A Practical Guide to the Preparation of Ca2+ Buffers Methods in Cell Biology. 40: 3-29. PMID 8201981 DOI: 10.1016/S0091-679X(08)61108-5  0.542
1994 Bassani JW, Qi M, Samarel AM, Bers DM. Contractile arrest increases sarcoplasmic reticulum calcium uptake and SERCA2 gene expression in cultured neonatal rat heart cells. Circulation Research. 74: 991-7. PMID 8156646 DOI: 10.1161/01.Res.74.5.991  0.578
1994 Perez-Reyes E, Yuan W, Wei X, Bers DM. Regulation of the cloned L-type cardiac calcium channel by cyclic-AMP-dependent protein kinase. Febs Letters. 342: 119-23. PMID 8143862 DOI: 10.1016/0014-5793(94)80484-2  0.524
1994 Yuan W, Bers DM. Ca-dependent facilitation of cardiac Ca current is due to Ca-calmodulin- dependent protein kinase American Journal of Physiology - Heart and Circulatory Physiology. 267. PMID 8092302 DOI: 10.1152/Ajpheart.1994.267.3.H982  0.569
1994 Mattiazzi A, Hove-Madsen L, Bers DM. Protein kinase inhibitors reduce SR Ca transport in permeabilized cardiac myocytes. The American Journal of Physiology. 267: H812-20. PMID 8067437 DOI: 10.1152/Ajpheart.1994.267.2.H812  0.572
1994 Bassani RA, Bassani JW, Bers DM. Relaxation in ferret ventricular myocytes: unusual interplay among calcium transport systems. The Journal of Physiology. 476: 295-308. PMID 8046644 DOI: 10.1113/Jphysiol.1994.Sp020131  0.585
1994 Bassani JW, Bassani RA, Bers DM. Relaxation in rabbit and rat cardiac cells: species-dependent differences in cellular mechanisms. The Journal of Physiology. 476: 279-93. PMID 8046643 DOI: 10.1113/Jphysiol.1994.Sp020130  0.575
1993 Hove-Madsen L, Bers DM. Sarcoplasmic reticulum Ca2+ uptake and thapsigargin sensitivity in permeabilized rabbit and rat ventricular myocytes. Circulation Research. 73: 820-8. PMID 8403253 DOI: 10.1161/01.Res.73.5.820  0.549
1993 Baudet S, Shaoulian R, Bers DM. Effects of thapsigargin and cyclopiazonic acid on twitch force and sarcoplasmic reticulum Ca2+ content of rabbit ventricular muscle. Circulation Research. 73: 813-9. PMID 8403252 DOI: 10.1161/01.Res.73.5.813  0.564
1993 Bassani JW, Bassani RA, Bers DM. Ca2+ cycling between sarcoplasmic reticulum and mitochondria in rabbit cardiac myocytes. The Journal of Physiology. 460: 603-21. PMID 8387590 DOI: 10.1113/Jphysiol.1993.Sp019489  0.547
1993 Bassani JW, Bassani RA, Bers DM. Twitch-dependent SR Ca accumulation and release in rabbit ventricular myocytes. The American Journal of Physiology. 265: C533-40. PMID 8368279 DOI: 10.1152/Ajpcell.1993.265.2.C533  0.555
1993 Bers DM, Stiffel VM. Ratio of ryanodine to dihydropyridine receptors in cardiac and skeletal muscle and implications for E-C coupling. The American Journal of Physiology. 264: C1587-93. PMID 8333507 DOI: 10.1152/Ajpcell.1993.264.6.C1587  0.378
1993 Bers DM, Bassani RA, Bassani JW, Baudet S, Hryshko LV. Paradoxical twitch potentiation after rest in cardiac muscle: increased fractional release of SR calcium. Journal of Molecular and Cellular Cardiology. 25: 1047-57. PMID 8283468 DOI: 10.1006/Jmcc.1993.1117  0.575
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