Shoukat Dedhar - Publications

University of British Columbia, Vancouver, Vancouver, BC, Canada 
Molecular Biology, Cell Biology

193 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2020 Brown WS, McDonald PC, Nemirovsky O, Awrey S, Chafe SC, Schaeffer DF, Li J, Renouf DJ, Stanger BZ, Dedhar S. Overcoming Adaptive Resistance to KRAS and MEK Inhibitors by Co-targeting mTORC1/2 Complexes in Pancreatic Cancer. Cell Reports. Medicine. 1: 100131. PMID 33294856 DOI: 10.1016/j.xcrm.2020.100131  0.412
2020 Mousavizadeh R, Hojabrpour P, Eltit F, McDonald PC, Dedhar S, McCormack RG, Duronio V, Jafarnejad SM, Scott A. β1 integrin, ILK and mTOR regulate collagen synthesis in mechanically loaded tendon cells. Scientific Reports. 10: 12644. PMID 32724089 DOI: 10.1038/S41598-020-69267-6  0.46
2020 Rothe K, Babaian A, Nakamichi N, Chen M, Chafe SC, Watanabe A, Forrest DL, Mager DL, Eaves CJ, Dedhar S, Jiang X. Integrin-Linked Kinase Mediates Therapeutic Resistance of Quiescent CML Stem Cells to Tyrosine Kinase Inhibitors. Cell Stem Cell. PMID 32413332 DOI: 10.1016/J.Stem.2020.04.005  0.491
2020 Yang J, Antin P, Berx G, Blanpain C, Brabletz T, Bronner M, Campbell K, Cano A, Casanova J, Christofori G, Dedhar S, Derynck R, Ford HL, Fuxe J, García de Herreros A, et al. Guidelines and definitions for research on epithelial-mesenchymal transition. Nature Reviews. Molecular Cell Biology. PMID 32300252 DOI: 10.1038/S41580-020-0237-9  0.304
2020 Morris EJ, Gillespie JA, Maxwell CA, Dedhar S. A Model of Differential Mammary Growth Initiation by Stat3 and Asymmetric Integrin-α6 Inheritance. Cell Reports. 30: 3605-3615.e5. PMID 32187533 DOI: 10.1016/J.Celrep.2020.02.079  0.378
2019 Tan J, Digicaylioglu M, Wang SXJ, Dresselhuis J, Dedhar S, Mills J. Insulin attenuates apoptosis in neuronal cells by an integrin-linked kinase-dependent mechanism. Heliyon. 5: e02294. PMID 31463398 DOI: 10.1016/J.Heliyon.2019.E02294  0.415
2019 Hedlund EE, McDonald PC, Nemirovsky O, Awrey S, Jensen LDE, Dedhar S. Harnessing Induced Essentiality: Targeting Carbonic Anhydrase IX and Angiogenesis Reduces Lung Metastasis of Triple Negative Breast Cancer Xenografts. Cancers. 11. PMID 31319613 DOI: 10.3390/Cancers11071002  0.37
2019 Chafe SC, McDonald PC, Saberi S, Nemirovsky O, Venkateswaran G, Burugu S, Gao D, Delaidelli A, Kyle AH, Baker JHE, Gillespie JA, Bashashati A, Minchinton AI, Zhou Y, Shah SP, ... Dedhar S, et al. Targeting hypoxia-induced carbonic anhydrase IX enhances immune checkpoint blockade locally and systemically. Cancer Immunology Research. PMID 31088846 DOI: 10.1158/2326-6066.Cir-18-0657  0.356
2019 McDonald PC, Chafe SC, Brown WS, Saberi S, Swayampakula M, Venkateswaran G, Nemirovsky O, Gillespie JA, Karasinska JM, Kalloger SE, Supuran CT, Schaeffer DF, Bashashati A, Shah SP, Topham JT, ... ... Dedhar S, et al. Regulation of pH by Carbonic Anhydrase 9 Mediates Survival of Pancreatic Cancer Cells With Activated KRAS in Response to Hypoxia. Gastroenterology. PMID 31078621 DOI: 10.1053/J.Gastro.2019.05.004  0.332
2018 McDonald PC, Swayampakula M, Dedhar S. Coordinated Regulation of Metabolic Transporters and Migration/Invasion by Carbonic Anhydrase IX. Metabolites. 8. PMID 29517989 DOI: 10.3390/Metabo8010020  0.412
2017 Boyd NH, Walker K, Fried J, Hackney JR, McDonald PC, Benavides GA, Spina R, Audia A, Scott SE, Libby CJ, Tran AN, Bevensee MO, Griguer C, Nozell S, Gillespie GY, ... ... Dedhar S, et al. Addition of carbonic anhydrase 9 inhibitor SLC-0111 to temozolomide treatment delays glioblastoma growth in vivo. Jci Insight. 2. PMID 29263302 DOI: 10.1172/Jci.Insight.92928  0.385
2017 Yoon SO, Shin S, Karreth FA, Buel GR, Jedrychowski MP, Plas DR, Dedhar S, Gygi SP, Roux PP, Dephoure N, Blenis J. Focal Adhesion- and IGF1R-Dependent Survival and Migratory Pathways Mediate Tumor Resistance to mTORC1/2 Inhibition. Molecular Cell. PMID 28757207 DOI: 10.1016/J.Molcel.2017.06.033  0.576
2017 Swayampakula M, McDonald PC, Vallejo M, Coyaud E, Chafe SC, Westerback A, Venkateswaran G, Shankar J, Gao G, Laurent EMN, Lou Y, Bennewith KL, Supuran CT, Nabi IR, Raught B, ... Dedhar S, et al. The interactome of metabolic enzyme carbonic anhydrase IX reveals novel roles in tumor cell migration and invadopodia/MMP14-mediated invasion. Oncogene. PMID 28692057 DOI: 10.1038/Onc.2017.219  0.426
2017 Morris EJ, Kawamura E, Gillespie JA, Balgi A, Kannan N, Muller WJ, Roberge M, Dedhar S. Stat3 regulates centrosome clustering in cancer cells via Stathmin/PLK1. Nature Communications. 8: 15289. PMID 28474672 DOI: 10.1038/Ncomms15289  0.396
2017 El Kharbili M, Robert C, Witkowski T, Danty-Berger E, Barbollat-Boutrand L, Masse I, Gadot N, de la Fouchardière A, McDonald PC, Dedhar S, Le Naour F, Degoul F, Berthier-Vergnes O. Tetraspanin 8 is a novel regulator of ILK-driven β1 integrin adhesion and signaling in invasive melanoma cells. Oncotarget. PMID 28188308 DOI: 10.18632/Oncotarget.15084  0.517
2017 Boyd NH, Walker K, McDonald PC, Bevensee MO, Gillespie YG, Nabors B, Dedhar S, Hjelmeland AB. Abstract 171: Targeting the tumor microenvironment: inhibition of carbonic anhydrase 9 impedes brain tumor initiating cell chemoresistance and delays glioblastoma growth in vivo Cancer Research. 77: 171-171. DOI: 10.1158/1538-7445.Am2017-171  0.337
2016 Al-Ghabkari A, Deng JT, McDonald PC, Dedhar S, Alshehri M, Walsh MP, MacDonald JA. A novel inhibitory effect of oxazol-5-one compounds on ROCKII signaling in human coronary artery vascular smooth muscle cells. Scientific Reports. 6: 32118. PMID 27573465 DOI: 10.1038/Srep32118  0.463
2016 McDonald PC, Chafe SC, Dedhar S. Overcoming Hypoxia-Mediated Tumor Progression: Combinatorial Approaches Targeting pH Regulation, Angiogenesis and Immune Dysfunction. Frontiers in Cell and Developmental Biology. 4: 27. PMID 27066484 DOI: 10.3389/Fcell.2016.00027  0.42
2016 Paolicchi E, Gemignani F, Krstic-Demonacos M, Dedhar S, Mutti L, Landi S. Targeting hypoxic response for cancer therapy. Oncotarget. PMID 26859576 DOI: 10.18632/Oncotarget.7229  0.357
2016 Rothe K, Babaian A, Nakamichi N, Chen M, Watanabe A, Mager D, Eaves CJ, Dedhar S, Jiang X. The Focal Adhesion Complex Ilk-Pinch-Parvin Is Key to Niche Interactions and Survival of Quiescent Stem Cells in Chronic Myeloid Leukemia In Vitro and In Vivo Blood. 128: 936-936. DOI: 10.1182/Blood.V128.22.936.936  0.466
2016 McDonald PC, Chafe SC, Vallejo M, Schaeffer D, Yapp D, Supuran CT, Stanger B, Parmar M, Renouf D, Dedhar S. Abstract 754: Targeting carbonic anhydrase IX in multiple pancreatic ductal adenocarcinoma models results in tumor growth inhibition and increased survival Cancer Research. 76: 754-754. DOI: 10.1158/1538-7445.Am2016-754  0.431
2016 Morris EJ, Kawamura E, Gillespie J, McDonald P, Muller W, Dedhar S. Abstract 2983: Stat3 regulates supernumerary centrosome clustering in cancer cells via Stathmin/PLK1 Cancer Research. 76: 2983-2983. DOI: 10.1158/1538-7445.Am2016-2983  0.42
2016 Walker K, Boyd N, McDonald P, Bevensee M, Gillespie Y, Nabors B, Dedhar S, Hjelmeland A. EXTH-26. TARGETING BRAIN TUMOR INITIATING CELL CHEMORESISTANCE WITH THE CARBONIC ANHYDRASE IX INHIBITOR SLC-0111 DELAYS GLIOBLASTOMA GROWTH IN VIVO Neuro-Oncology. 18: vi65-vi65. DOI: 10.1093/Neuonc/Now212.270  0.351
2015 Chafe SC, Dedhar S. Carving out its niche: A role for carbonic anhydrase IX in pre-metastatic niche development. Oncoimmunology. 4: e1048955. PMID 26587316 DOI: 10.1080/2162402X.2015.1048955  0.342
2015 Morris EJ, Assi K, Salh B, Dedhar S. Integrin-linked kinase links dynactin-1/dynactin-2 with cortical integrin receptors to orient the mitotic spindle relative to the substratum. Scientific Reports. 5: 8389. PMID 25669897 DOI: 10.1038/Srep08389  0.452
2015 Chafe SC, Lou Y, Sceneay J, Vallejo M, Hamilton MJ, McDonald PC, Bennewith KL, Möller A, Dedhar S. Carbonic anhydrase IX promotes myeloid-derived suppressor cell mobilization and establishment of a metastatic niche by stimulating G-CSF production. Cancer Research. 75: 996-1008. PMID 25623234 DOI: 10.1158/0008-5472.Can-14-3000  0.392
2015 Chafe SC, Lou Y, Sceneay J, Vallejo M, McDonald PC, Möller A, Dedhar S. Abstract B03: Hypoxia-induced carbonic anhydrase IX promotes MDSC recruitment and establishment of the breast cancer premetastatic niche by stimulating G-CSF production Cancer Research. 75. DOI: 10.1158/1538-7445.Chtme14-B03  0.388
2015 Rothe K, Watanabe A, Forrest D, Dedhar S, Eaves C, Jiang X. The focal adhesion protein ilk is key to niche interactions and survival of CML stem cells Experimental Hematology. 43: S91. DOI: 10.1016/J.Exphem.2015.06.240  0.347
2014 Cano-Peñalver JL, Griera M, Serrano I, Rodríguez-Puyol D, Dedhar S, de Frutos S, Rodríguez-Puyol M. Integrin-linked kinase regulates tubular aquaporin-2 content and intracellular location: a link between the extracellular matrix and water reabsorption. Faseb Journal : Official Publication of the Federation of American Societies For Experimental Biology. 28: 3645-59. PMID 24784577 DOI: 10.1096/Fj.13-249250  0.36
2014 Peng H, Talebzadeh-Farrooji M, Osborne MJ, Prokop JW, McDonald PC, Karar J, Hou Z, He M, Kebebew E, Orntoft T, Herlyn M, Caton AJ, Fredericks W, Malkowicz B, Paterno CS, ... ... Dedhar S, et al. LIMD2 is a small LIM-only protein overexpressed in metastatic lesions that regulates cell motility and tumor progression by directly binding to and activating the integrin-linked kinase. Cancer Research. 74: 1390-403. PMID 24590809 DOI: 10.1158/0008-5472.Can-13-1275  0.54
2014 Teo ZL, McQueen-Miscamble L, Turner K, Martinez G, Madakashira B, Dedhar S, Robinson ML, de Iongh RU. Integrin linked kinase (ILK) is required for lens epithelial cell survival, proliferation and differentiation. Experimental Eye Research. 121: 130-42. PMID 24472646 DOI: 10.1016/J.Exer.2014.01.013  0.405
2014 Dai J, Matsui T, Abel ED, Dedhar S, Gerszten RE, Seidman CE, Seidman JG, Rosenzweig A. Deep sequence analysis of gene expression identifies osteopontin as a downstream effector of integrin-linked kinase (ILK) in cardiac-specific ILK knockout mice. Circulation. Heart Failure. 7: 184-93. PMID 24319095 DOI: 10.1161/Circheartfailure.113.000649  0.426
2014 McDonald PC, Dedhar S. Carbonic anhydrase IX (CAIX) as a mediator of hypoxia-induced stress response in cancer cells. Sub-Cellular Biochemistry. 75: 255-69. PMID 24146383 DOI: 10.1007/978-94-007-7359-2_13  0.429
2014 El-Hoss J, Arabian A, Dedhar S, St-Arnaud R. Inactivation of the integrin-linked kinase (ILK) in osteoblasts increases mineralization. Gene. 533: 246-52. PMID 24095779 DOI: 10.1016/j.gene.2013.09.074  0.341
2014 Rothe K, Watanabe A, Forrest DL, Dedhar S, Eaves CJ, Jiang X. Integrin-Linked Kinase As a Key Mediator of Stromal Cell-Enhanced Resistance of Primitive CML Cells to Tyrosine Kinase Inhibitors Blood. 124: 402-402. DOI: 10.1182/Blood.V124.21.402.402  0.451
2014 McDonald PC, Sanghera J, Singh M, Lou Y, Vallejo M, Supuran CT, Dedhar S. Abstract 841: Therapeutic targeting of cancer cells in the hypoxic microenvironment using an orally bioavailable small molecule inhibitor of carbonic anhydrase IX Cancer Research. 74: 841-841. DOI: 10.1158/1538-7445.Am2014-841  0.389
2013 Serrano I, McDonald PC, Lock F, Muller WJ, Dedhar S. Inactivation of the Hippo tumour suppressor pathway by integrin-linked kinase. Nature Communications. 4: 2976. PMID 24356468 DOI: 10.1038/Ncomms3976  0.487
2013 Kawamura E, Fielding AB, Kannan N, Balgi A, Eaves CJ, Roberge M, Dedhar S. Identification of novel small molecule inhibitors of centrosome clustering in cancer cells. Oncotarget. 4: 1763-76. PMID 24091544 DOI: 10.18632/Oncotarget.1198  0.38
2013 Barakat B, Yu L, Lo C, Vu D, De Luca E, Cain JE, Martelotto LG, Martellotto LG, Dedhar S, Sadler AJ, Wang D, Watkins DN, Hannigan GE. Interaction of smoothened with integrin-linked kinase in primary cilia mediates Hedgehog signalling. Embo Reports. 14: 837-44. PMID 23877428 DOI: 10.1038/Embor.2013.110  0.419
2013 Serrano I, De Frutos S, Griera M, Medrano D, Rodríguez-Puyol M, Dedhar S, Ruiz-Torres MP, Rodríguez-Puyol D. Ilk conditional deletion in adult animals increases cyclic GMP-dependent vasorelaxation. Cardiovascular Research. 99: 535-44. PMID 23715557 DOI: 10.1093/Cvr/Cvt131  0.36
2013 Lim S, Kawamura E, Fielding AB, Maydan M, Dedhar S. Integrin-linked kinase regulates interphase and mitotic microtubule dynamics. Plos One. 8: e53702. PMID 23349730 DOI: 10.1371/Journal.Pone.0053702  0.446
2013 Lock FE, McDonald PC, Lou Y, Serrano I, Chafe SC, Ostlund C, Aparicio S, Winum JY, Supuran CT, Dedhar S. Targeting carbonic anhydrase IX depletes breast cancer stem cells within the hypoxic niche. Oncogene. 32: 5210-9. PMID 23208505 DOI: 10.1038/onc.2012.550  0.304
2013 Serrano I, McDonald PC, Lock FE, Dedhar S. Role of the integrin-linked kinase (ILK)/Rictor complex in TGFβ-1-induced epithelial-mesenchymal transition (EMT). Oncogene. 32: 50-60. PMID 22310280 DOI: 10.1038/Onc.2012.30  0.442
2013 Serrano I, Muller WJ, Dedhar S. Abstract 769: Integrin-Linked Kinase (ILK) breaks Merlin's spell to inhibit the Hippo tumor suppressor pathway and activate the YAP oncogene. Cancer Research. 73: 769-769. DOI: 10.1158/1538-7445.Am2013-769  0.549
2013 Barakat B, Yu L, Lo C, Vu D, Luca ED, Cain JE, Martellotto LG, Dedhar S, Sadler AJ, Wang D, Watkins DN, Hannigan GE. Erratum: Interaction of smoothened with integrin-linked kinase in primary cilia mediates Hedgehog signalling (EMBO Reports (2013) 14 ( 679-682) Doi:10.1038/embor.2013.97) Embo Reports. 14. DOI: 10.1038/Embor.2013.150  0.449
2012 Becker-Santos DD, Guo Y, Ghaffari M, Vickers ED, Lehman M, Altamirano-Dimas M, Oloumi A, Furukawa J, Sharma M, Wang Y, Dedhar S, Cox ME. Integrin-linked kinase as a target for ERG-mediated invasive properties in prostate cancer models. Carcinogenesis. 33: 2558-67. PMID 23027626 DOI: 10.1093/Carcin/Bgs285  0.427
2012 Serrano I, Díez-Marqués ML, Rodríguez-Puyol M, Herrero-Fresneda I, Raimundo García del M, Dedhar S, Ruiz-Torres MP, Rodríguez-Puyol D. Integrin-linked kinase (ILK) modulates wound healing through regulation of hepatocyte growth factor (HGF). Experimental Cell Research. 318: 2470-81. PMID 22971619 DOI: 10.1016/J.Yexcr.2012.08.001  0.427
2012 Cammas L, Wolfe J, Choi SY, Dedhar S, Beggs HE. Integrin-linked kinase deletion in the developing lens leads to capsule rupture, impaired fiber migration and non-apoptotic epithelial cell death Investigative Ophthalmology & Visual Science. 53: 3067-3081. PMID 22491404 DOI: 10.1167/Iovs.11-9128  0.48
2012 McDonald PC, Winum JY, Supuran CT, Dedhar S. Recent developments in targeting carbonic anhydrase IX for cancer therapeutics. Oncotarget. 3: 84-97. PMID 22289741 DOI: 10.18632/Oncotarget.422  0.414
2012 Matsui Y, Assi K, Ogawa O, Raven PA, Dedhar S, Gleave ME, Salh B, So AI. The importance of integrin-linked kinase in the regulation of bladder cancer invasion. International Journal of Cancer. Journal International Du Cancer. 130: 521-31. PMID 21351095 DOI: 10.1002/Ijc.26008  0.43
2012 Kawamura E, Fielding A, Kannan N, Eaves C, Roberge M, Dedhar S. Abstract 3887: A screen for new cancer specific drugs that target centrosome clustering Cancer Research. 72: 3887-3887. DOI: 10.1158/1538-7445.Am2012-3887  0.391
2012 Lock FE, McDonald PC, Lou Y, Supuran CT, Dedhar S. Abstract 3305: The role of carbonic anhydrase IX in tumor hypoxia, metastasis and the cancer stem cell niche Cancer Research. 72: 3305-3305. DOI: 10.1158/1538-7445.Am2012-3305  0.447
2012 Serrano-Martinez I, McDonald PC, Dedhar S. Abstract 324: The integrin-linked kinase (ILK) / Rictor complex is required for TGFβ-1-induced epithelial to mesenchymal transition (EMT) Cancer Research. 72: 324-324. DOI: 10.1158/1538-7445.Am2012-324  0.551
2011 Bennewith KL, Dedhar S. Targeting hypoxic tumour cells to overcome metastasis. Bmc Cancer. 11: 504. PMID 22128892 DOI: 10.1186/1471-2407-11-504  0.355
2011 Touisni N, Maresca A, McDonald PC, Lou Y, Scozzafava A, Dedhar S, Winum JY, Supuran CT. Glycosyl coumarin carbonic anhydrase IX and XII inhibitors strongly attenuate the growth of primary breast tumors. Journal of Medicinal Chemistry. 54: 8271-7. PMID 22077347 DOI: 10.1021/Jm200983E  0.336
2011 Assi K, Patterson S, Dedhar S, Owen D, Levings M, Salh B. Role of epithelial integrin-linked kinase in promoting intestinal inflammation: effects on CCL2, fibronectin and the T cell repertoire. Bmc Immunology. 12: 42. PMID 21806815 DOI: 10.1186/1471-2172-12-42  0.464
2011 Shen D, Li J, Lepore JJ, Anderson TJ, Sinha S, Lin AY, Cheng L, Cohen ED, Roberts JD, Dedhar S, Parmacek MS, Gerszten RE. Aortic aneurysm generation in mice with targeted deletion of integrin-linked kinase in vascular smooth muscle cells. Circulation Research. 109: 616-28. PMID 21778429 DOI: 10.1161/Circresaha.110.239343  0.509
2011 Hannigan GE, McDonald PC, Walsh MP, Dedhar S. Integrin-linked kinase: not so 'pseudo' after all. Oncogene. 30: 4375-85. PMID 21602880 DOI: 10.1038/Onc.2011.177  0.551
2011 Lou Y, McDonald PC, Oloumi A, Chia S, Ostlund C, Ahmadi A, Kyle A, Auf dem Keller U, Leung S, Huntsman D, Clarke B, Sutherland BW, Waterhouse D, Bally M, Roskelley C, ... ... Dedhar S, et al. Targeting tumor hypoxia: suppression of breast tumor growth and metastasis by novel carbonic anhydrase IX inhibitors. Cancer Research. 71: 3364-76. PMID 21415165 DOI: 10.1158/0008-5472.Can-10-4261  0.399
2011 Pacchiano F, Carta F, McDonald PC, Lou Y, Vullo D, Scozzafava A, Dedhar S, Supuran CT. Ureido-substituted benzenesulfonamides potently inhibit carbonic anhydrase IX and show antimetastatic activity in a model of breast cancer metastasis. Journal of Medicinal Chemistry. 54: 1896-902. PMID 21361354 DOI: 10.1021/Jm101541X  0.372
2011 Perez VA, Ali Z, Alastalo TP, Ikeno F, Sawada H, Lai YJ, Kleisli T, Spiekerkoetter E, Qu X, Rubinos LH, Ashley E, Amieva M, Dedhar S, Rabinovitch M. BMP promotes motility and represses growth of smooth muscle cells by activation of tandem Wnt pathways. The Journal of Cell Biology. 192: 171-88. PMID 21220513 DOI: 10.1083/Jcb.201008060  0.439
2011 Faralli JA, Newman JR, Sheibani N, Dedhar S, Peters DM. Integrin-linked kinase regulates integrin signaling in human trabecular meshwork cells Investigative Ophthalmology and Visual Science. 52: 1684-1692. PMID 21071740 DOI: 10.1167/Iovs.10-6397  0.509
2011 Fielding AB, Lim S, Montgomery K, Dobreva I, Dedhar S. A critical role of integrin-linked kinase, ch-TOG and TACC3 in centrosome clustering in cancer cells. Oncogene. 30: 521-34. PMID 20838383 DOI: 10.1038/Onc.2010.431  0.462
2011 Lim S, Fielding AB, Kawamura E, Dedhar S. Abstract 2989: Integrin-linked kinase regulates mitotic spindle dynamics and its overexpression leads to resistance to paclitaxel-induced cell death Cancer Research. 71: 2989-2989. DOI: 10.1158/1538-7445.Am2011-2989  0.466
2011 Assi K, Patterson S, Owen DA, Dedhar S, Levings MK, Salh B. Integrin-Linked Kinase Promotes Colitis Through Regulation of CCL2, Fibronectin and Regulatory T Cells Gastroenterology. 140: S-636. DOI: 10.1016/S0016-5085(11)62632-2  0.479
2011 Assi K, Owen DA, Dedhar S, Salh B. Conditional Integrin-Linked Kinase Knockout in Epithelial Cells Reveals a Unique Phenotype With Simultaneously Enhanced Proliferation and Apoptosis Gastroenterology. 140: S-83-S-84. DOI: 10.1016/S0016-5085(11)60340-5  0.527
2010 Kalra J, Sutherland BW, Stratford AL, Dragowska W, Gelmon KA, Dedhar S, Dunn SE, Bally MB. Suppression of Her2/neu expression through ILK inhibition is regulated by a pathway involving TWIST and YB-1. Oncogene. 29: 6343-56. PMID 20838384 DOI: 10.1038/Onc.2010.366  0.477
2010 Maydan M, McDonald PC, Sanghera J, Yan J, Rallis C, Pinchin S, Hannigan GE, Foster LJ, Ish-Horowicz D, Walsh MP, Dedhar S. Integrin-linked kinase is a functional Mn2+-dependent protein kinase that regulates glycogen synthase kinase-3β (GSK-3beta) phosphorylation. Plos One. 5: e12356. PMID 20827300 DOI: 10.1371/Journal.Pone.0012356  0.523
2010 auf dem Keller U, Bellac CL, Li Y, Lou Y, Lange PF, Ting R, Harwig C, Kappelhoff R, Dedhar S, Adam MJ, Ruth TJ, Bénard F, Perrin DM, Overall CM. Novel matrix metalloproteinase inhibitor [18F]marimastat-aryltrifluoroborate as a probe for in vivo positron emission tomography imaging in cancer. Cancer Research. 70: 7562-9. PMID 20729277 DOI: 10.1158/0008-5472.Can-10-1584  0.307
2010 Oloumi A, Maidan M, Lock FE, Tearle H, McKinney S, Muller WJ, Aparicio SA, Dedhar S. Cooperative signaling between Wnt1 and integrin-linked kinase induces accelerated breast tumor development. Breast Cancer Research : Bcr. 12: R38. PMID 20565980 DOI: 10.1186/Bcr2592  0.513
2010 Dossa T, Arabian A, Windle JJ, Dedhar S, Teitelbaum SL, Ross FP, Roodman GD, St-Arnaud R. Osteoclast-specific inactivation of the integrin-linked kinase (ILK) inhibits bone resorption. Journal of Cellular Biochemistry. 110: 960-7. PMID 20564195 DOI: 10.1002/Jcb.22609  0.366
2010 Pontier SM, Huck L, White DE, Rayment J, Sanguin-Gendreau V, Hennessy B, Zuo D, St-Arnaud R, Mills GB, Dedhar S, Marshall CJ, Muller WJ. Integrin-linked kinase has a critical role in ErbB2 mammary tumor progression: Implications for human breast cancer Oncogene. 29: 3374-3385. PMID 20305688 DOI: 10.1038/Onc.2010.86  0.493
2010 Muranyi AL, Dedhar S, Hogge DE. Targeting integrin linked kinase and FMS-like tyrosine kinase-3 is cytotoxic to acute myeloid leukemia stem cells but spares normal progenitors. Leukemia Research. 34: 1358-65. PMID 20193963 DOI: 10.1016/J.Leukres.2010.01.006  0.415
2010 Esfandiarei M, Yazdi SA, Gray V, Dedhar S, van Breemen C. Integrin-linked kinase functions as a downstream signal of platelet-derived growth factor to regulate actin polymerization and vascular smooth muscle cell migration. Bmc Cell Biology. 11: 16. PMID 20178627 DOI: 10.1186/1471-2121-11-16  0.485
2010 Lou Y, McDonald PC, Oloumi A, Chia S, Kyle A, Keller Uad, Fotovati A, Gray V, Leung S, Huntsman D, Clarke B, Waterhouse D, Bally M, Roskelley C, Overall C, ... ... Dedhar S, et al. Abstract 455: Hypoxia induced carbonic anhydrase IX is essential for the growth and metastasis of breast tumors Cancer Research. 70: 455-455. DOI: 10.1158/1538-7445.Am10-455  0.381
2009 McDonald PC, Dedhar S, Keller C. Integrin-linked kinase: both Jekyll and Hyde in rhabdomyosarcoma. The Journal of Clinical Investigation. 119: 1452-5. PMID 19504719 DOI: 10.1172/Jci39457  0.441
2009 Kalra J, Warburton C, Fang K, Edwards L, Daynard T, Waterhouse D, Dragowska W, Sutherland BW, Dedhar S, Gelmon K, Bally M. QLT0267, a small molecule inhibitor targeting integrin-linked kinase (ILK), and docetaxel can combine to produce synergistic interactions linked to enhanced cytotoxicity, reductions in P-AKT levels, altered F-actin architecture and improved treatment outcomes in an orthotopic breast cancer model. Breast Cancer Research : Bcr. 11: R25. PMID 19409087 DOI: 10.1186/Bcr2252  0.432
2009 Muranyi AL, Dedhar S, Hogge DE. Combined inhibition of integrin linked kinase and FMS-like tyrosine kinase 3 is cytotoxic to acute myeloid leukemia progenitor cells. Experimental Hematology. 37: 450-60. PMID 19302919 DOI: 10.1016/J.Exphem.2009.01.002  0.534
2009 Akhtar N, Marlow R, Lambert E, Schatzmann F, Lowe ET, Cheung J, Katz E, Li W, Wu C, Dedhar S, Naylor MJ, Streuli CH. Molecular dissection of integrin signalling proteins in the control of mammary epithelial development and differentiation. Development (Cambridge, England). 136: 1019-27. PMID 19211680 DOI: 10.1242/Dev.028423  0.514
2009 Fielding AB, Dedhar S. The mitotic functions of integrin-linked kinase. Cancer Metastasis Reviews. 28: 99-111. PMID 19153670 DOI: 10.1007/S10555-008-9177-0  0.504
2008 Gkretsi V, Apte U, Mars WM, Bowen WC, Luo JH, Yang Y, Yu YP, Orr A, St-Arnaud R, Dedhar S, Kaestner KH, Wu C, Michalopoulos GK. Liver-specific ablation of integrin-linked kinase in mice results in abnormal histology, enhanced cell proliferation, and hepatomegaly. Hepatology (Baltimore, Md.). 48: 1932-41. PMID 18846549 DOI: 10.1002/Hep.22537  0.41
2008 McDonald PC, Fielding AB, Dedhar S. Integrin-linked kinase--essential roles in physiology and cancer biology. Journal of Cell Science. 121: 3121-32. PMID 18799788 DOI: 10.1242/Jcs.017996  0.511
2008 Lou Y, Preobrazhenska O, auf dem Keller U, Sutcliffe M, Barclay L, McDonald PC, Roskelley C, Overall CM, Dedhar S. Epithelial-mesenchymal transition (EMT) is not sufficient for spontaneous murine breast cancer metastasis. Developmental Dynamics : An Official Publication of the American Association of Anatomists. 237: 2755-68. PMID 18773493 DOI: 10.1002/Dvdy.21658  0.4
2008 McPhee TR, McDonald PC, Oloumi A, Dedhar S. Integrin-linked kinase regulates E-cadherin expression through PARP-1. Developmental Dynamics : An Official Publication of the American Association of Anatomists. 237: 2737-47. PMID 18773488 DOI: 10.1002/Dvdy.21685  0.425
2008 Tucker KL, Sage T, Stevens JM, Jordan PA, Jones S, Barrett NE, St-Arnaud R, Frampton J, Dedhar S, Gibbins JM. A dual role for integrin-linked kinase in platelets: regulating integrin function and alpha-granule secretion. Blood. 112: 4523-31. PMID 18772455 DOI: 10.1182/Blood-2008-03-148502  0.4
2008 Fielding AB, Dobreva I, Dedhar S. Beyond focal adhesions: integrin-linked kinase associates with tubulin and regulates mitotic spindle organization. Cell Cycle (Georgetown, Tex.). 7: 1899-906. PMID 18604167 DOI: 10.4161/Cc.7.13.6204  0.514
2008 Guo S, Kim WJ, Lok J, Lee SR, Besancon E, Luo BH, Stins MF, Wang X, Dedhar S, Lo EH. Neuroprotection via matrix-trophic coupling between cerebral endothelial cells and neurons. Proceedings of the National Academy of Sciences of the United States of America. 105: 7582-7. PMID 18495934 DOI: 10.1073/Pnas.0801105105  0.301
2008 McDonald PC, Oloumi A, Mills J, Dobreva I, Maidan M, Gray V, Wederell ED, Bally MB, Foster LJ, Dedhar S. Rictor and integrin-linked kinase interact and regulate Akt phosphorylation and cancer cell survival. Cancer Research. 68: 1618-24. PMID 18339839 DOI: 10.1158/0008-5472.Can-07-5869  0.556
2008 Dobreva I, Fielding A, Foster LJ, Dedhar S. Mapping the integrin-linked kinase interactome using SILAC. Journal of Proteome Research. 7: 1740-9. PMID 18327965 DOI: 10.1021/Pr700852R  0.451
2008 Assi K, Mills J, Owen D, Ong C, St Arnaud R, Dedhar S, Salh B. Integrin-linked kinase regulates cell proliferation and tumour growth in murine colitis-associated carcinogenesis. Gut. 57: 931-40. PMID 18326560 DOI: 10.1136/Gut.2007.142778  0.506
2008 Fielding AB, Dobreva I, McDonald PC, Foster LJ, Dedhar S. Integrin-linked kinase localizes to the centrosome and regulates mitotic spindle organization. The Journal of Cell Biology. 180: 681-9. PMID 18283114 DOI: 10.1083/Jcb.200710074  0.503
2008 Nakrieko KA, Welch I, Dupuis H, Bryce D, Pajak A, St Arnaud R, Dedhar S, D'Souza SJ, Dagnino L. Impaired hair follicle morphogenesis and polarized keratinocyte movement upon conditional inactivation of integrin-linked kinase in the epidermis. Molecular Biology of the Cell. 19: 1462-73. PMID 18234842 DOI: 10.1091/Mbc.E07-06-0526  0.46
2008 Edwards LA, Woo J, Huxham LA, Verreault M, Dragowska WH, Chiu G, Rajput A, Kyle AH, Kalra J, Yapp D, Yan H, Minchinton AI, Huntsman D, Daynard T, Waterhouse DN, ... ... Dedhar S, et al. Suppression of VEGF secretion and changes in glioblastoma multiforme microenvironment by inhibition of integrin-linked kinase (ILK). Molecular Cancer Therapeutics. 7: 59-70. PMID 18202010 DOI: 10.1158/1535-7163.Mct-07-0329  0.442
2008 Muranyi AL, Dedhar S, Hogge DE. QLT0267, a Small Molecule Inhibitor of ILK and FLT3 Is Cytotoxic to Acute Myeloid Leukemia (AML) ‘Stem Cells’ Detected in Immunodeficient Mice. Blood. 112: 950-950. DOI: 10.1182/Blood.V112.11.950.950  0.397
2007 Santos ND, Habibi G, Wang M, Law JH, Andrews HN, Wei D, Triche T, Dedhar S, Dunn SE. Urokinase-type Plasminogen Activator (uPA) is Inhibited with QLT0267 a Small Molecule Targeting Integrin-linked Kinase (ILK). Translational Oncogenomics. 2: 85-97. PMID 23645983  0.406
2007 Gheyara AL, Vallejo-Illarramendi A, Zang K, Mei L, St-Arnaud R, Dedhar S, Reichardt LF. Deletion of integrin-linked kinase from skeletal muscles of mice resembles muscular dystrophy due to alpha 7 beta 1-integrin deficiency. The American Journal of Pathology. 171: 1966-77. PMID 18055553 DOI: 10.2353/Ajpath.2007.070555  0.401
2007 Wong RP, Ng P, Dedhar S, Li G. The role of integrin-linked kinase in melanoma cell migration, invasion, and tumor growth. Molecular Cancer Therapeutics. 6: 1692-700. PMID 17575101 DOI: 10.1158/1535-7163.Mct-07-0134  0.505
2007 Hannigan GE, Coles JG, Dedhar S. Integrin-linked kinase at the heart of cardiac contractility, repair, and disease. Circulation Research. 100: 1408-14. PMID 17525380 DOI: 10.1161/01.Res.0000265233.40455.62  0.38
2007 Guo W, Jiang H, Gray V, Dedhar S, Rao Y. Role of the integrin-linked kinase (ILK) in determining neuronal polarity. Developmental Biology. 306: 457-68. PMID 17490631 DOI: 10.1016/J.Ydbio.2007.03.019  0.367
2007 Gkretsi V, Mars WM, Bowen WC, Barua L, Yang Y, Guo L, St-Arnaud R, Dedhar S, Wu C, Michalopoulos GK. Loss of integrin linked kinase from mouse hepatocytes in vitro and in vivo results in apoptosis and hepatitis. Hepatology (Baltimore, Md.). 45: 1025-34. PMID 17385211 DOI: 10.1002/Hep.21540  0.476
2007 Wang B, Li S, Dedhar S, Cleary PP. Paxillin phosphorylation: bifurcation point downstream of integrin-linked kinase (ILK) in streptococcal invasion. Cellular Microbiology. 9: 1519-28. PMID 17298394 DOI: 10.1111/J.1462-5822.2007.00889.X  0.497
2007 Li Y, Yang J, Luo JH, Dedhar S, Liu Y. Tubular epithelial cell dedifferentiation is driven by the helix-loop-helix transcriptional inhibitor Id1. Journal of the American Society of Nephrology : Jasn. 18: 449-60. PMID 17202424 DOI: 10.1681/Asn.2006030236  0.444
2007 Tucker KL, Stevens JM, Jordan PA, Sage T, Jones S, Barrett NE, St-Arnaud R, Frampton J, Dedhar S, Gibbins JM. Integrin Linked Kinase Is Important in Platelet Signalling and Function. Blood. 110: 420-420. DOI: 10.1182/Blood.V110.11.420.420  0.388
2007 Thompson EW, Savagner P, Dedhar S, Kalluri R. Epithelial-mesenchymal transitions - New insights into signaling, development and pathogenesis Cells Tissues Organs. 185: 5-6. DOI: 10.1159/000104413  0.346
2006 Naska S, Park KJ, Hannigan GE, Dedhar S, Miller FD, Kaplan DR. An essential role for the integrin-linked kinase-glycogen synthase kinase-3 beta pathway during dendrite initiation and growth. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 26: 13344-56. PMID 17182785 DOI: 10.1523/Jneurosci.4462-06.2006  0.411
2006 White DE, Coutu P, Shi YF, Tardif JC, Nattel S, St Arnaud R, Dedhar S, Muller WJ. Targeted ablation of ILK from the murine heart results in dilated cardiomyopathy and spontaneous heart failure. Genes & Development. 20: 2355-60. PMID 16951252 DOI: 10.1101/Gad.1458906  0.365
2006 Esfandiarei M, Suarez A, Amaral A, Si X, Rahmani M, Dedhar S, McManus BM. Novel role for integrin-linked kinase in modulation of coxsackievirus B3 replication and virus-induced cardiomyocyte injury. Circulation Research. 99: 354-61. PMID 16840719 DOI: 10.1161/01.Res.0000237022.72726.01  0.422
2006 Dai C, Stolz DB, Bastacky SI, St-Arnaud R, Wu C, Dedhar S, Liu Y. Essential role of integrin-linked kinase in podocyte biology: Bridging the integrin and slit diaphragm signaling. Journal of the American Society of Nephrology : Jasn. 17: 2164-75. PMID 16837631 DOI: 10.1681/Asn.2006010033  0.4
2006 Oloumi A, Syam S, Dedhar S. Modulation of Wnt3a-mediated nuclear beta-catenin accumulation and activation by integrin-linked kinase in mammalian cells. Oncogene. 25: 7747-57. PMID 16799642 DOI: 10.1038/Sj.Onc.1209752  0.464
2006 Bertram J, Peacock JW, Tan C, Mui AL, Chung SW, Gleave ME, Dedhar S, Cox ME, Ong CJ. Inhibition of the phosphatidylinositol 3'-kinase pathway promotes autocrine Fas-induced death of phosphatase and tensin homologue-deficient prostate cancer cells. Cancer Research. 66: 4781-8. PMID 16651432 DOI: 10.1158/0008-5472.Can-05-3173  0.47
2006 Rosanò L, Spinella F, Di Castro V, Dedhar S, Nicotra MR, Natali PG, Bagnato A. Integrin-linked kinase functions as a downstream mediator of endothelin-1 to promote invasive behavior in ovarian carcinoma. Molecular Cancer Therapeutics. 5: 833-42. PMID 16648553 DOI: 10.1158/1535-7163.Mct-05-0523  0.535
2006 El-Aouni C, Herbach N, Blattner SM, Henger A, Rastaldi MP, Jarad G, Miner JH, Moeller MJ, St-Arnaud R, Dedhar S, Holzman LB, Wanke R, Kretzler M. Podocyte-specific deletion of integrin-linked kinase results in severe glomerular basement membrane alterations and progressive glomerulosclerosis. Journal of the American Society of Nephrology : Jasn. 17: 1334-44. PMID 16611717 DOI: 10.1681/Asn.2005090921  0.44
2006 Lee JM, Dedhar S, Kalluri R, Thompson EW. The epithelial-mesenchymal transition: new insights in signaling, development, and disease. The Journal of Cell Biology. 172: 973-81. PMID 16567498 DOI: 10.1083/Jcb.200601018  0.361
2006 Edwards LA, Verreault M, Thiessen B, Dragowska WH, Hu Y, Yeung JH, Dedhar S, Bally MB. Combined inhibition of the phosphatidylinositol 3-kinase/Akt and Ras/mitogen-activated protein kinase pathways results in synergistic effects in glioblastoma cells. Molecular Cancer Therapeutics. 5: 645-54. PMID 16546979 DOI: 10.1158/1535-7163.Mct-05-0099  0.565
2006 Wang B, Yurecko RS, Dedhar S, Cleary PP. Integrin-linked kinase is an essential link between integrins and uptake of bacterial pathogens by epithelial cells. Cellular Microbiology. 8: 257-66. PMID 16441436 DOI: 10.1111/J.1462-5822.2005.00618.X  0.51
2006 Mulholland DJ, Dedhar S, Wu H, Nelson CC. PTEN and GSK3beta: key regulators of progression to androgen-independent prostate cancer. Oncogene. 25: 329-37. PMID 16421604 DOI: 10.1038/Sj.Onc.1209020  0.367
2006 Mills J, Niewmierzycka A, Oloumi A, Rico B, St-Arnaud R, Mackenzie IR, Mawji NM, Wilson J, Reichardt LF, Dedhar S. Critical role of integrin-linked kinase in granule cell precursor proliferation and cerebellar development. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 26: 830-40. PMID 16421303 DOI: 10.1523/Jneurosci.1852-05.2006  0.553
2006 Troussard AA, McDonald PC, Wederell ED, Mawji NM, Filipenko NR, Gelmon KA, Kucab JE, Dunn SE, Emerman JT, Bally MB, Dedhar S. Preferential dependence of breast cancer cells versus normal cells on integrin-linked kinase for protein kinase B/Akt activation and cell survival. Cancer Research. 66: 393-403. PMID 16397254 DOI: 10.1158/0008-5472.Can-05-2304  0.514
2006 Ahmed N, Maines-Bandiera S, Quinn MA, Unger WG, Dedhar S, Auersperg N. Molecular pathways regulating EGF-induced epithelio-mesenchymal transition in human ovarian surface epithelium. American Journal of Physiology. Cell Physiology. 290: C1532-42. PMID 16394028 DOI: 10.1152/Ajpcell.00478.2005  0.557
2006 Dedhar S, Mcdonald P, Bally M. 594 POSTER Combined targeting of mTOR and ILK for maximal suppression of cancer cell growth, Akt activation and cell survival European Journal of Cancer Supplements. 4: 180. DOI: 10.1016/S1359-6349(06)70599-7  0.337
2005 Rosanò L, Spinella F, Di Castro V, Nicotra MR, Dedhar S, de Herreros AG, Natali PG, Bagnato A. Endothelin-1 promotes epithelial-to-mesenchymal transition in human ovarian cancer cells. Cancer Research. 65: 11649-57. PMID 16357176 DOI: 10.1158/0008-5472.Can-05-2123  0.46
2005 Liu E, Sinha S, Williams C, Cyrille M, Heller E, Snapper SB, Georgopoulos K, St-Arnaud R, Force T, Dedhar S, Gerszten RE. Targeted deletion of integrin-linked kinase reveals a role in T-cell chemotaxis and survival. Molecular and Cellular Biology. 25: 11145-55. PMID 16314534 DOI: 10.1128/Mcb.25.24.11145-11155.2005  0.545
2005 Chen H, Huang XN, Yan W, Chen K, Guo L, Tummalapali L, Dedhar S, St-Arnaud R, Wu C, Sepulveda JL. Role of the integrin-linked kinase/PINCH1/alpha-parvin complex in cardiac myocyte hypertrophy. Laboratory Investigation; a Journal of Technical Methods and Pathology. 85: 1342-56. PMID 16170337 DOI: 10.1038/Labinvest.3700345  0.402
2005 Barker TH, Baneyx G, Cardó-Vila M, Workman GA, Weaver M, Menon PM, Dedhar S, Rempel SA, Arap W, Pasqualini R, Vogel V, Sage EH. SPARC regulates extracellular matrix organization through its modulation of integrin-linked kinase activity. The Journal of Biological Chemistry. 280: 36483-93. PMID 16115889 DOI: 10.1074/Jbc.M504663200  0.52
2005 Niewmierzycka A, Mills J, St-Arnaud R, Dedhar S, Reichardt LF. Integrin-linked kinase deletion from mouse cortex results in cortical lamination defects resembling cobblestone lissencephaly. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 25: 7022-31. PMID 16049178 DOI: 10.1523/Jneurosci.1695-05.2005  0.45
2005 Filipenko NR, Attwell S, Roskelley C, Dedhar S. Integrin-linked kinase activity regulates Rac- and Cdc42-mediated actin cytoskeleton reorganization via alpha-PIX. Oncogene. 24: 5837-49. PMID 15897874 DOI: 10.1038/Sj.Onc.1208737  0.816
2005 Sutherland BW, Kucab J, Wu J, Lee C, Cheang MC, Yorida E, Turbin D, Dedhar S, Nelson C, Pollak M, Leighton Grimes H, Miller K, Badve S, Huntsman D, Blake-Gilks C, et al. Akt phosphorylates the Y-box binding protein 1 at Ser102 located in the cold shock domain and affects the anchorage-independent growth of breast cancer cells. Oncogene. 24: 4281-92. PMID 15806160 DOI: 10.1038/Sj.Onc.1208590  0.525
2005 Edwards LA, Thiessen B, Dragowska WH, Daynard T, Bally MB, Dedhar S. Inhibition of ILK in PTEN-mutant human glioblastomas inhibits PKB/Akt activation, induces apoptosis, and delays tumor growth. Oncogene. 24: 3596-605. PMID 15782140 DOI: 10.1038/Sj.Onc.1208427  0.564
2005 Qian Y, Zhong X, Flynn DC, Zheng JZ, Qiao M, Wu C, Dedhar S, Shi X, Jiang BH. ILK mediates actin filament rearrangements and cell migration and invasion through PI3K/Akt/Rac1 signaling. Oncogene. 24: 3154-65. PMID 15735674 DOI: 10.1038/Sj.Onc.1208525  0.556
2005 Hannigan G, Troussard AA, Dedhar S. Integrin-linked kinase: a cancer therapeutic target unique among its ILK. Nature Reviews. Cancer. 5: 51-63. PMID 15630415 DOI: 10.1038/Nrc1524  0.526
2004 Friedrich EB, Liu E, Sinha S, Cook S, Milstone DS, MacRae CA, Mariotti M, Kuhlencordt PJ, Force T, Rosenzweig A, St-Arnaud R, Dedhar S, Gerszten RE. Integrin-linked kinase regulates endothelial cell survival and vascular development. Molecular and Cellular Biology. 24: 8134-44. PMID 15340074 DOI: 10.1128/Mcb.24.18.8134-8144.2004  0.511
2004 Quélo I, Gauthier C, Hannigan GE, Dedhar S, St-Arnaud R. Integrin-linked kinase regulates the nuclear entry of the c-Jun coactivator alpha-NAC and its coactivation potency. The Journal of Biological Chemistry. 279: 43893-9. PMID 15299025 DOI: 10.1074/Jbc.M406310200  0.375
2004 Barberà MJ, Puig I, Domínguez D, Julien-Grille S, Guaita-Esteruelas S, Peiró S, Baulida J, Francí C, Dedhar S, Larue L, García de Herreros A. Regulation of Snail transcription during epithelial to mesenchymal transition of tumor cells. Oncogene. 23: 7345-54. PMID 15286702 DOI: 10.1038/Sj.Onc.1207990  0.451
2004 Edwards LA, Shabbits JA, Bally M, Dedhar S. Integrin-linked kinase (ILK) in combination molecular targeting. Cancer Treatment and Research. 119: 59-75. PMID 15164873 DOI: 10.1007/1-4020-7847-1_4  0.432
2004 Oloumi A, McPhee T, Dedhar S. Regulation of E-cadherin expression and beta-catenin/Tcf transcriptional activity by the integrin-linked kinase. Biochimica Et Biophysica Acta. 1691: 1-15. PMID 15053919 DOI: 10.1016/J.Bbamcr.2003.12.002  0.519
2004 McHardy LM, Sinotte R, Troussard A, Sheldon C, Church J, Williams DE, Andersen RJ, Dedhar S, Roberge M, Roskelley CD. The tumor invasion inhibitor dihydromotuporamine C activates RHO, remodels stress fibers and focal adhesions, and stimulates sodium-proton exchange. Cancer Research. 64: 1468-74. PMID 14973060 DOI: 10.1158/0008-5472.Can-03-2733  0.446
2004 Tan C, Cruet-Hennequart S, Troussard A, Fazli L, Costello P, Sutton K, Wheeler J, Gleave M, Sanghera J, Dedhar S. Regulation of tumor angiogenesis by integrin-linked kinase (ILK). Cancer Cell. 5: 79-90. PMID 14749128 DOI: 10.1016/S1535-6108(03)00281-2  0.447
2004 Dedhar S, Troussard A, Tan C. 136 Regulation of tumour angiogenesis and cell survival by integrin-linked kinase (ILK): pre-clinical evaluation of novel small molecule inhibitors European Journal of Cancer Supplements. 2: 44. DOI: 10.1016/S1359-6349(04)80143-5  0.374
2004 Edwards L, Thiessen B, Dragowska V, Daynard T, Dedhar S, Bally M. 61 Mutant-PTEN leads to constitutive integrin-linked kinase (ILK) activity that regulates PKB/Akt activity in glioblastoma cancer cells and targeting ILK results in tumor growth-delay in vivo European Journal of Cancer Supplements. 2: 22. DOI: 10.1016/S1359-6349(04)80069-7  0.446
2003 Attwell S, Mills J, Troussard A, Wu C, Dedhar S. Integration of cell attachment, cytoskeletal localization, and signaling by integrin-linked kinase (ILK), CH-ILKBP, and the tumor suppressor PTEN. Molecular Biology of the Cell. 14: 4813-25. PMID 12960424 DOI: 10.1091/Mbc.E03-05-0308  0.813
2003 Persad S, Dedhar S. The role of integrin-linked kinase (ILK) in cancer progression. Cancer Metastasis Reviews. 22: 375-84. PMID 12884912 DOI: 10.1023/A:1023777013659  0.538
2003 Terpstra L, Prud'homme J, Arabian A, Takeda S, Karsenty G, Dedhar S, St-Arnaud R. Reduced chondrocyte proliferation and chondrodysplasia in mice lacking the integrin-linked kinase in chondrocytes. The Journal of Cell Biology. 162: 139-48. PMID 12835312 DOI: 10.1083/Jcb.200302066  0.407
2003 Marotta A, Parhar K, Owen D, Dedhar S, Salh B. Characterisation of integrin-linked kinase signalling in sporadic human colon cancer. British Journal of Cancer. 88: 1755-62. PMID 12771992 DOI: 10.1038/Sj.Bjc.6600939  0.375
2003 Troussard AA, Mawji NM, Ong C, Mui A, St -Arnaud R, Dedhar S. Conditional knock-out of integrin-linked kinase demonstrates an essential role in protein kinase B/Akt activation. The Journal of Biological Chemistry. 278: 22374-8. PMID 12686550 DOI: 10.1074/Jbc.M303083200  0.547
2003 Cruet-Hennequart S, Maubant S, Luis J, Gauduchon P, Staedel C, Dedhar S. alpha(v) integrins regulate cell proliferation through integrin-linked kinase (ILK) in ovarian cancer cells. Oncogene. 22: 1688-702. PMID 12642872 DOI: 10.1038/Sj.Onc.1206347  0.433
2003 Mills J, Digicaylioglu M, Legg AT, Young CE, Young SS, Barr AM, Fletcher L, O'Connor TP, Dedhar S. Role of integrin-linked kinase in nerve growth factor-stimulated neurite outgrowth. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 23: 1638-48. PMID 12629168 DOI: 10.1523/Jneurosci.23-05-01638.2003  0.502
2003 White D, Blaess S, Mueller U, Dedhar S, Cardiff R, St Arnaud R, Muller W. Integrin-mediated signal transduction in transgenic mouse models of human breast cancer Breast Cancer Research. 5. DOI: 10.1186/Bcr663  0.413
2003 Ragaz J, Lippman M, Rijn MV, Brodie A, Jelovac D, Nielsen T, Dedhar S, Huntsman D, Hayes M, Dunn S, Cheung M, Sledge G, Chia S, Harris A, Bajdik C, et al. 2. Survival Impact of HER-2/Neu, Cox-2, Urokinase Plasminogen Activator (upa), Cytokeratin 17/5,6 and other Markers with Long-Term Outcome of Early Breast Cancer. Report from the British Columbia Tissue Micro-Array Project (BCTMAP) Breast Cancer Research and Treatment. 79: 278-278. DOI: 10.1023/A:1023979226714  0.31
2002 Yoganathan N, Yee A, Zhang Z, Leung D, Yan J, Fazli L, Kojic DL, Costello PC, Jabali M, Dedhar S, Sanghera J. Integrin-linked kinase, a promising cancer therapeutic target: biochemical and biological properties. Pharmacology & Therapeutics. 93: 233-42. PMID 12191615 DOI: 10.1016/S0163-7258(02)00192-4  0.583
2002 Guaita S, Puig I, Franci C, Garrido M, Dominguez D, Batlle E, Sancho E, Dedhar S, De Herreros AG, Baulida J. Snail induction of epithelial to mesenchymal transition in tumor cells is accompanied by MUC1 repression and ZEB1 expression. The Journal of Biological Chemistry. 277: 39209-16. PMID 12161443 DOI: 10.1074/Jbc.M206400200  0.428
2002 Friedrich EB, Sinha S, Li L, Dedhar S, Force T, Rosenzweig A, Gerszten RE. Role of integrin-linked kinase in leukocyte recruitment. The Journal of Biological Chemistry. 277: 16371-5. PMID 11856758 DOI: 10.1074/Jbc.M201240200  0.46
2002 Tan C, Mui A, Dedhar S. Integrin-linked kinase regulates inducible nitric oxide synthase and cyclooxygenase-2 expression in an NF-κB-dependent manner Journal of Biological Chemistry. 277: 3109-3116. PMID 11724787 DOI: 10.1074/Jbc.M108673200  0.393
2001 White DE, Cardiff RD, Dedhar S, Muller WJ. Mammary epithelial-specific expression of the integrin-linked kinase (ILK) results in the induction of mammary gland hyperplasias and tumors in transgenic mice. Oncogene. 20: 7064-72. PMID 11704830 DOI: 10.1038/Sj.Onc.1204910  0.473
2001 Wu C, Dedhar S. Integrin-linked kinase (ILK) and its interactors: a new paradigm for the coupling of extracellular matrix to actin cytoskeleton and signaling complexes. The Journal of Cell Biology. 155: 505-10. PMID 11696562 DOI: 10.1083/Jcb.200108077  0.492
2001 Marotta A, Tan C, Gray V, Malik S, Gallinger S, Sanghera J, Dupuis B, Owen D, Dedhar S, Salh B. Dysregulation of integrin-linked kinase (ILK) signaling in colonic polyposis. Oncogene. 20: 6250-7. PMID 11593435 DOI: 10.1038/Sj.Onc.1204791  0.362
2001 Persad S, Troussard AA, McPhee TR, Mulholland DJ, Dedhar S. Tumor suppressor PTEN inhibits nuclear accumulation of β-catenin and T cell/lymphoid enhancer factor 1-mediated transcriptional activation Journal of Cell Biology. 153: 1161-1173. PMID 11402061 DOI: 10.1083/Jcb.153.6.1161  0.398
2001 Persad S, Attwell S, Gray V, Mawji N, Deng JT, Leung D, Yan J, Sanghera J, Walsh MP, Dedhar S. Regulation of protein kinase B/Akt-serine 473 phosphorylation by integrin-linked kinase: critical roles for kinase activity and amino acids arginine 211 and serine 343. The Journal of Biological Chemistry. 276: 27462-9. PMID 11313365 DOI: 10.1074/Jbc.M102940200  0.802
2001 Tan C, Costello P, Sanghera J, Dominguez D, Baulida J, de Herreros AG, Dedhar S. Inhibition of integrin linked kinase (ILK) suppresses beta-catenin-Lef/Tcf-dependent transcription and expression of the E-cadherin repressor, snail, in APC-/- human colon carcinoma cells. Oncogene. 20: 133-40. PMID 11244511 DOI: 10.1038/Sj.Onc.1204052  0.447
2001 Mulholland DJ, Dedhar S, Vogl AW. Rat Seminiferous Epithelium Contains a Unique Junction (Ectoplasmic Specialization) with Signaling Properties Both of Cell/Cell and Cell/Matrix Junctions Biology of Reproduction. 64: 396-407. PMID 11133699 DOI: 10.1095/Biolreprod64.1.396  0.458
2001 Dedhar S. Integrin-linked kinase regulates E-cadherin expression by means of the transcription factor Snail Nature Genetics. 27: 50-50. DOI: 10.1038/87052  0.417
2000 Troussard AA, Costello P, Yoganathan TN, Kumagai S, Roskelley CD, Dedhar S. The integrin linked kinase (ILK) induces an invasive phenotype via AP-1 transcription factor-dependent upregulation of matrix metalloproteinase 9 (MMP-9). Oncogene. 19: 5444-52. PMID 11114721 DOI: 10.1038/Sj.Onc.1203928  0.445
2000 Yoganathan TN, Costello P, Chen X, Jabali M, Yan J, Leung D, Zhang Z, Yee A, Dedhar S, Sanghera J. Integrin-linked kinase (ILK): a "hot" therapeutic target. Biochemical Pharmacology. 60: 1115-9. PMID 11007949 DOI: 10.1016/S0006-2952(00)00444-5  0.579
2000 Attwell S, Roskelley C, Dedhar S. The integrin-linked kinase (ILK) suppresses anoikis. Oncogene. 19: 3811-5. PMID 10949937 DOI: 10.1038/Sj.Onc.1203711  0.822
2000 D'Amico M, Hulit J, Amanatullah DF, Zafonte BT, Albanese C, Bouzahzah B, Fu M, Augenlicht LH, Donehower LA, Takemaru KI, Moon RT, Davis R, Lisanti MP, Shtutman M, Zhurinsky J, ... ... Dedhar S, et al. The integrated-linked kinase regulates the cyclin D1 gene through glycogen synthase kinase 3β and cAMP-responsive element-binding protein-dependent pathways Journal of Biological Chemistry. 275: 32649-32657. PMID 10915780 DOI: 10.1074/Jbc.M000643200  0.377
2000 Rauch F, Prud'homme J, Arabian A, Dedhar S, St-Arnaud R. Heart, brain, and body wall defects in mice lacking calreticulin. Experimental Cell Research. 256: 105-11. PMID 10739657 DOI: 10.1006/Excr.2000.4818  0.348
2000 Persad S, Attwell S, Gray V, Delcommenne M, Troussard A, Sanghera J, Dedhar S. Inhibition of integrin-linked kinase (ILK) suppresses activation of protein kinase B/Akt and induces cell cycle arrest and apoptosis of PTEN-mutant prostate cancer cells. Proceedings of the National Academy of Sciences of the United States of America. 97: 3207-12. PMID 10716737 DOI: 10.1073/Pnas.97.7.3207  0.813
2000 Dedhar S. Cell-substrate interactions and signaling through ILK. Current Opinion in Cell Biology. 12: 250-6. PMID 10712922 DOI: 10.1016/S0955-0674(99)00083-6  0.458
2000 Coppolino MG, Dedhar S. Bi-directional signal transduction by integrin receptors. The International Journal of Biochemistry & Cell Biology. 32: 171-88. PMID 10687952 DOI: 10.1016/S1357-2725(99)00043-6  0.317
1999 Troussard AA, Tan C, Yoganathan TN, Dedhar S. Cell-extracellular matrix interactions stimulate the AP-1 transcription factor in an integrin-linked kinase- and glycogen synthase kinase 3-dependent manner. Molecular and Cellular Biology. 19: 7420-7. PMID 10523630 DOI: 10.1128/MCB.19.11.7420  0.481
1999 Dedhar S, Williams B, Hannigan G. Integrin-linked kinase (ILK): a regulator of integrin and growth-factor signalling. Trends in Cell Biology. 9: 319-23. PMID 10407411 DOI: 10.1016/S0962-8924(99)01612-8  0.367
1999 Dedhar S. Integrins and signal transduction. Current Opinion in Hematology. 6: 37-43. PMID 9915552 DOI: 10.1097/00062752-199901000-00007  0.318
1999 COPPOLINO MG, DEDHAR S. Ligand-specific, transient interaction between integrins and calreticulin during cell adhesion to extracellular matrix proteins is dependent upon phosphorylation/dephosphorylation events Biochemical Journal. 340: 41-50. DOI: 10.1042/BJ3400041  0.405
1999 COPPOLINO MG, DEDHAR S. Ligand-specific, transient interaction between integrins and calreticulin during cell adhesion to extracellular matrix proteins is dependent upon phosphorylation/dephosphorylation events Biochemical Journal. 340: 41. DOI: 10.1042/0264-6021:3400041  0.341
1998 Wang F, Weaver VM, Petersen OW, Larabell CA, Dedhar S, Briand P, Lupu R, Bissell MJ. Reciprocal interactions between beta1-integrin and epidermal growth factor receptor in three-dimensional basement membrane breast cultures: a different perspective in epithelial biology. Proceedings of the National Academy of Sciences of the United States of America. 95: 14821-6. PMID 9843973 DOI: 10.1073/Pnas.95.25.14821  0.476
1998 Delcommenne M, Tan C, Gray V, Rue L, Woodgett J, Dedhar S. Phosphoinositide-3-OH kinase-dependent regulation of glycogen synthase kinase 3 and protein kinase B/AKT by the integrin-linked kinase. Proceedings of the National Academy of Sciences of the United States of America. 95: 11211-6. PMID 9736715 DOI: 10.1073/Pnas.95.19.11211  0.564
1998 Novak A, Hsu SC, Leung-Hagesteijn C, Radeva G, Papkoff J, Montesano R, Roskelley C, Grosschedl R, Dedhar S. Cell adhesion and the integrin-linked kinase regulate the LEF-1 and β-catenin signaling pathways Proceedings of the National Academy of Sciences of the United States of America. 95: 4374-4379. PMID 9539744 DOI: 10.1073/Pnas.95.8.4374  0.499
1998 Wu C, Keightley SY, Leung-Hagesteijn C, Radeva G, Coppolino M, Goicoechea S, McDonald JA, Dedhar S. Integrin-linked protein kinase regulates fibronectin matrix assembly, E- cadherin expression, and tumorigenicity Journal of Biological Chemistry. 273: 528-536. PMID 9417112 DOI: 10.1074/Jbc.273.1.528  0.412
1997 Radeva G, Petrocelli T, Behrend E, Leung-Hagesteijn C, Filmus J, Slingerland J, Dedhar S. Overexpression of the integrin-linked kinase promotes anchorage- independent cell cycle progression Journal of Biological Chemistry. 272: 13937-13944. PMID 9153256 DOI: 10.1074/Jbc.272.21.13937  0.443
1997 Coppolino MG, Woodside MJ, Demaurex N, Grinstein S, St-Arnaud R, Dedhar S. Calreticulin is essential for integrin-mediated calcium signalling and cell adhesion. Nature. 386: 843-7. PMID 9126744 DOI: 10.1038/386843A0  0.325
1997 Hannigan GE, Dedhar S. Protein kinase mediators of integrin signal transduction. Journal of Molecular Medicine (Berlin, Germany). 75: 35-44. PMID 9020382 DOI: 10.1007/s001090050084  0.366
1997 Dedhar S, Hannigan GE. Integrin cytoplasmic interactions and bidirectional transmembrane signalling. Current Opinion in Cell Biology. 8: 657-69. PMID 8939656 DOI: 10.1016/S0955-0674(96)80107-4  0.354
1997 Wu C, McDonald J, Dedhar S. Overexpression of integrin linked kinase (ILK) induces oncogenic transformation and fibronectin matrix assembly in epithelial cells Matrix Biology. 16: 69. DOI: 10.1016/S0945-053X(97)90080-9  0.396
1996 Hannigan GE, Leung-Hagesteijn C, Fitz-Gibbon L, Coppolino MG, Radeva G, Filmus J, Bell JC, Dedhar S. Regulation of cell adhesion and anchorage-dependent growth by a new β1-integrin-linked protein kinase Nature. 379: 91-96. PMID 8538749 DOI: 10.1038/379091a0  0.45
1995 Demetriou M, Nabi IR, Coppolino M, Dedhar S, Dennis JW. Reduced contact-inhibition and substratum adhesion in epithelial cells expressing GlcNAc-transferase V. The Journal of Cell Biology. 130: 383-92. PMID 7615638 DOI: 10.1083/Jcb.130.2.383  0.305
1994 Kruk PA, Uitto VJ, Firth JD, Dedhar S, Auersperg N. Reciprocal interactions between human ovarian surface epithelial cells and adjacent extracellular matrix Experimental Cell Research. 215: 97-108. PMID 7525326 DOI: 10.1006/Excr.1994.1320  0.405
1991 Dedhar S. Integrins and tumor invasion. Bioessays : News and Reviews in Molecular, Cellular and Developmental Biology. 12: 583-90. PMID 2080913 DOI: 10.1002/Bies.950121205  0.419
1990 Dedhar S, Saulnier R. Alterations in integrin receptor expression on chemically transformed human cells: specific enhancement of laminin and collagen receptor complexes. The Journal of Cell Biology. 110: 481-9. PMID 1688858 DOI: 10.1083/Jcb.110.2.481  0.391
1989 Dedhar S. Signal transduction via the beta 1 integrins is a required intermediate in interleukin-1 beta induction of alkaline phosphatase activity in human osteosarcoma cells. Experimental Cell Research. 183: 207-14. PMID 2786815 DOI: 10.1016/0014-4827(89)90430-8  0.354
1989 Dedhar S. Regulation of expression of the cell adhesion receptors, integrins, by recombinant human interleukin-1 beta in human osteosarcoma cells: inhibition of cell proliferation and stimulation of alkaline phosphatase activity. Journal of Cellular Physiology. 138: 291-9. PMID 2521862 DOI: 10.1002/Jcp.1041380210  0.368
1988 Dedhar S, Gaboury L, Galloway P, Eaves C. Human granulocyte-macrophage colony-stimulating factor is a growth factor active on a variety of cell types of nonhemopoietic origin. Proceedings of the National Academy of Sciences of the United States of America. 85: 9253-7. PMID 3057504 DOI: 10.1073/Pnas.85.23.9253  0.379
1985 Dedhar S, Hartley D, Fitz-Gibbons D, Phillips G, Goldie JH. Heterogeneity in the specific activity and methotrexate sensitivity of dihydrofolate reductase from blast cells of acute myelogenous leukemia patients. Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology. 3: 1545-52. PMID 3863895 DOI: 10.1200/Jco.1985.3.11.1545  0.327
1985 Dedhar S, Goldie JH. Methotrexate-resistant human promyelocytic leukemia (HL-60) cells express a dihydrofolate reductase with altered properties associated with increased enzyme activity. Biochemical and Biophysical Research Communications. 129: 536-45. PMID 3860203 DOI: 10.1016/0006-291X(85)90185-8  0.32
1981 Goldie JH, Krystal G, Hartley D, Gudauskas G, Dedhar S. A methotrexate insensitive variant of folate reductase present in two lines of methotrexate-resistant L5178Y cells. European Journal of Cancer. 16: 1539-46. PMID 7227429 DOI: 10.1016/0014-2964(80)90026-2  0.312
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