Shoukat Dedhar - Publications

University of British Columbia, Vancouver, Vancouver, BC, Canada 
Molecular Biology, Cell Biology

85 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2019 Tan J, Digicaylioglu M, Wang SXJ, Dresselhuis J, Dedhar S, Mills J. Insulin attenuates apoptosis in neuronal cells by an integrin-linked kinase-dependent mechanism. Heliyon. 5: e02294. PMID 31463398 DOI: 10.1016/j.heliyon.2019.e02294  0.36
2016 Al-Ghabkari A, Deng JT, McDonald PC, Dedhar S, Alshehri M, Walsh MP, MacDonald JA. A novel inhibitory effect of oxazol-5-one compounds on ROCKII signaling in human coronary artery vascular smooth muscle cells. Scientific Reports. 6: 32118. PMID 27573465 DOI: 10.1038/srep32118  0.36
2015 Morris EJ, Assi K, Salh B, Dedhar S. Integrin-linked kinase links dynactin-1/dynactin-2 with cortical integrin receptors to orient the mitotic spindle relative to the substratum. Scientific Reports. 5: 8389. PMID 25669897 DOI: 10.1038/srep08389  0.36
2015 Chafe SC, Lou Y, Sceneay J, Vallejo M, Hamilton MJ, McDonald PC, Bennewith KL, Möller A, Dedhar S. Carbonic anhydrase IX promotes myeloid-derived suppressor cell mobilization and establishment of a metastatic niche by stimulating G-CSF production. Cancer Research. 75: 996-1008. PMID 25623234 DOI: 10.1158/0008-5472.CAN-14-3000  0.36
2014 Peng H, Talebzadeh-Farrooji M, Osborne MJ, Prokop JW, McDonald PC, Karar J, Hou Z, He M, Kebebew E, Orntoft T, Herlyn M, Caton AJ, Fredericks W, Malkowicz B, Paterno CS, ... ... Dedhar S, et al. LIMD2 is a small LIM-only protein overexpressed in metastatic lesions that regulates cell motility and tumor progression by directly binding to and activating the integrin-linked kinase. Cancer Research. 74: 1390-403. PMID 24590809 DOI: 10.1158/0008-5472.CAN-13-1275  0.36
2014 Teo ZL, McQueen-Miscamble L, Turner K, Martinez G, Madakashira B, Dedhar S, Robinson ML, de Iongh RU. Integrin linked kinase (ILK) is required for lens epithelial cell survival, proliferation and differentiation. Experimental Eye Research. 121: 130-42. PMID 24472646 DOI: 10.1016/j.exer.2014.01.013  0.36
2014 Dai J, Matsui T, Abel ED, Dedhar S, Gerszten RE, Seidman CE, Seidman JG, Rosenzweig A. Deep sequence analysis of gene expression identifies osteopontin as a downstream effector of integrin-linked kinase (ILK) in cardiac-specific ILK knockout mice. Circulation. Heart Failure. 7: 184-93. PMID 24319095 DOI: 10.1161/CIRCHEARTFAILURE.113.000649  0.36
2014 McDonald PC, Dedhar S. Carbonic anhydrase IX (CAIX) as a mediator of hypoxia-induced stress response in cancer cells. Sub-Cellular Biochemistry. 75: 255-69. PMID 24146383 DOI: 10.1007/978-94-007-7359-2_13  0.36
2014 Pan J, Lau J, Mesak F, Hundal N, Pourghiasian M, Liu Z, Bénard F, Dedhar S, Supuran CT, Lin KS. Synthesis and evaluation of 18F-labeled carbonic anhydrase IX inhibitors for imaging with positron emission tomography. Journal of Enzyme Inhibition and Medicinal Chemistry. 29: 249-55. PMID 23463940 DOI: 10.3109/14756366.2013.773994  0.36
2013 Kawamura E, Fielding AB, Kannan N, Balgi A, Eaves CJ, Roberge M, Dedhar S. Identification of novel small molecule inhibitors of centrosome clustering in cancer cells. Oncotarget. 4: 1763-76. PMID 24091544  0.36
2013 Barakat B, Yu L, Lo C, Vu D, De Luca E, Cain JE, Martelotto LG, Martellotto LG, Dedhar S, Sadler AJ, Wang D, Watkins DN, Hannigan GE. Interaction of smoothened with integrin-linked kinase in primary cilia mediates Hedgehog signalling. Embo Reports. 14: 837-44. PMID 23877428 DOI: 10.1038/embor.2013.150  0.36
2013 Pan J, Pourghiasian M, Hundal N, Lau J, Bénard F, Dedhar S, Lin KS. f-[18F]fluoroethanol and 3-[18F]fluoropropanol: facile preparation, biodistribution in mice, and their application as nucleophiles in the synthesis of [18F]fluoroalkyl aryl ester and ether PET tracers. Nuclear Medicine and Biology. 40: 850-7. PMID 23774003 DOI: 10.1016/j.nucmedbio.2013.04.009  0.36
2012 Becker-Santos DD, Guo Y, Ghaffari M, Vickers ED, Lehman M, Altamirano-Dimas M, Oloumi A, Furukawa J, Sharma M, Wang Y, Dedhar S, Cox ME. Integrin-linked kinase as a target for ERG-mediated invasive properties in prostate cancer models. Carcinogenesis. 33: 2558-67. PMID 23027626 DOI: 10.1093/carcin/bgs285  0.36
2012 Cammas L, Wolfe J, Choi SY, Dedhar S, Beggs HE. Integrin-linked kinase deletion in the developing lens leads to capsule rupture, impaired fiber migration and non-apoptotic epithelial cell death Investigative Ophthalmology & Visual Science. 53: 3067-3081. PMID 22491404  0.36
2012 Matsui Y, Assi K, Ogawa O, Raven PA, Dedhar S, Gleave ME, Salh B, So AI. The importance of integrin-linked kinase in the regulation of bladder cancer invasion. International Journal of Cancer. Journal International Du Cancer. 130: 521-31. PMID 21351095 DOI: 10.1002/ijc.26008  0.36
2011 Shen D, Li J, Lepore JJ, Anderson TJ, Sinha S, Lin AY, Cheng L, Cohen ED, Roberts JD, Dedhar S, Parmacek MS, Gerszten RE. Aortic aneurysm generation in mice with targeted deletion of integrin-linked kinase in vascular smooth muscle cells. Circulation Research. 109: 616-28. PMID 21778429 DOI: 10.1161/CIRCRESAHA.110.239343  0.36
2011 Lou Y, McDonald PC, Oloumi A, Chia S, Ostlund C, Ahmadi A, Kyle A, Auf dem Keller U, Leung S, Huntsman D, Clarke B, Sutherland BW, Waterhouse D, Bally M, Roskelley C, ... ... Dedhar S, et al. Targeting tumor hypoxia: suppression of breast tumor growth and metastasis by novel carbonic anhydrase IX inhibitors. Cancer Research. 71: 3364-76. PMID 21415165 DOI: 10.1158/0008-5472.CAN-10-4261  0.36
2011 Faralli JA, Newman JR, Sheibani N, Dedhar S, Peters DM. Integrin-linked kinase regulates integrin signaling in human trabecular meshwork cells Investigative Ophthalmology and Visual Science. 52: 1684-1692. PMID 21071740 DOI: 10.1167/iovs.10-6397  0.36
2011 Fielding AB, Lim S, Montgomery K, Dobreva I, Dedhar S. A critical role of integrin-linked kinase, ch-TOG and TACC3 in centrosome clustering in cancer cells. Oncogene. 30: 521-34. PMID 20838383 DOI: 10.1038/onc.2010.431  0.36
2010 Kalra J, Sutherland BW, Stratford AL, Dragowska W, Gelmon KA, Dedhar S, Dunn SE, Bally MB. Suppression of Her2/neu expression through ILK inhibition is regulated by a pathway involving TWIST and YB-1. Oncogene. 29: 6343-56. PMID 20838384 DOI: 10.1038/onc.2010.366  0.36
2010 Maydan M, McDonald PC, Sanghera J, Yan J, Rallis C, Pinchin S, Hannigan GE, Foster LJ, Ish-Horowicz D, Walsh MP, Dedhar S. Integrin-linked kinase is a functional Mn2+-dependent protein kinase that regulates glycogen synthase kinase-3β (GSK-3beta) phosphorylation. Plos One. 5: e12356. PMID 20827300 DOI: 10.1371/journal.pone.0012356  0.36
2010 Pontier SM, Huck L, White DE, Rayment J, Sanguin-Gendreau V, Hennessy B, Zuo D, St-Arnaud R, Mills GB, Dedhar S, Marshall CJ, Muller WJ. Integrin-linked kinase has a critical role in ErbB2 mammary tumor progression: Implications for human breast cancer Oncogene. 29: 3374-3385. PMID 20305688 DOI: 10.1038/onc.2010.86  0.36
2010 Esfandiarei M, Yazdi SA, Gray V, Dedhar S, van Breemen C. Integrin-linked kinase functions as a downstream signal of platelet-derived growth factor to regulate actin polymerization and vascular smooth muscle cell migration. Bmc Cell Biology. 11: 16. PMID 20178627 DOI: 10.1186/1471-2121-11-16  0.36
2009 Kalra J, Warburton C, Fang K, Edwards L, Daynard T, Waterhouse D, Dragowska W, Sutherland BW, Dedhar S, Gelmon K, Bally M. QLT0267, a small molecule inhibitor targeting integrin-linked kinase (ILK), and docetaxel can combine to produce synergistic interactions linked to enhanced cytotoxicity, reductions in P-AKT levels, altered F-actin architecture and improved treatment outcomes in an orthotopic breast cancer model. Breast Cancer Research : Bcr. 11: R25. PMID 19409087 DOI: 10.1186/bcr2252  0.36
2009 Akhtar N, Marlow R, Lambert E, Schatzmann F, Lowe ET, Cheung J, Katz E, Li W, Wu C, Dedhar S, Naylor MJ, Streuli CH. Molecular dissection of integrin signalling proteins in the control of mammary epithelial development and differentiation. Development (Cambridge, England). 136: 1019-27. PMID 19211680 DOI: 10.1242/dev.028423  0.36
2008 Gkretsi V, Apte U, Mars WM, Bowen WC, Luo JH, Yang Y, Yu YP, Orr A, St-Arnaud R, Dedhar S, Kaestner KH, Wu C, Michalopoulos GK. Liver-specific ablation of integrin-linked kinase in mice results in abnormal histology, enhanced cell proliferation, and hepatomegaly. Hepatology (Baltimore, Md.). 48: 1932-41. PMID 18846549 DOI: 10.1002/hep.22537  0.36
2008 Lou Y, Preobrazhenska O, auf dem Keller U, Sutcliffe M, Barclay L, McDonald PC, Roskelley C, Overall CM, Dedhar S. Epithelial-mesenchymal transition (EMT) is not sufficient for spontaneous murine breast cancer metastasis. Developmental Dynamics : An Official Publication of the American Association of Anatomists. 237: 2755-68. PMID 18773493 DOI: 10.1002/dvdy.21658  0.56
2008 Tucker KL, Sage T, Stevens JM, Jordan PA, Jones S, Barrett NE, St-Arnaud R, Frampton J, Dedhar S, Gibbins JM. A dual role for integrin-linked kinase in platelets: regulating integrin function and alpha-granule secretion. Blood. 112: 4523-31. PMID 18772455 DOI: 10.1182/blood-2008-03-148502  0.36
2008 McDonald PC, Oloumi A, Mills J, Dobreva I, Maidan M, Gray V, Wederell ED, Bally MB, Foster LJ, Dedhar S. Rictor and integrin-linked kinase interact and regulate Akt phosphorylation and cancer cell survival. Cancer Research. 68: 1618-24. PMID 18339839 DOI: 10.1158/0008-5472.CAN-07-5869  0.36
2008 Dobreva I, Fielding A, Foster LJ, Dedhar S. Mapping the integrin-linked kinase interactome using SILAC. Journal of Proteome Research. 7: 1740-9. PMID 18327965 DOI: 10.1021/pr700852r  0.36
2008 Fielding AB, Dobreva I, McDonald PC, Foster LJ, Dedhar S. Integrin-linked kinase localizes to the centrosome and regulates mitotic spindle organization. The Journal of Cell Biology. 180: 681-9. PMID 18283114 DOI: 10.1083/jcb.200710074  0.36
2008 Nakrieko KA, Welch I, Dupuis H, Bryce D, Pajak A, St Arnaud R, Dedhar S, D'Souza SJ, Dagnino L. Impaired hair follicle morphogenesis and polarized keratinocyte movement upon conditional inactivation of integrin-linked kinase in the epidermis. Molecular Biology of the Cell. 19: 1462-73. PMID 18234842 DOI: 10.1091/mbc.E07-06-0526  0.36
2008 Edwards LA, Woo J, Huxham LA, Verreault M, Dragowska WH, Chiu G, Rajput A, Kyle AH, Kalra J, Yapp D, Yan H, Minchinton AI, Huntsman D, Daynard T, Waterhouse DN, ... ... Dedhar S, et al. Suppression of VEGF secretion and changes in glioblastoma multiforme microenvironment by inhibition of integrin-linked kinase (ILK). Molecular Cancer Therapeutics. 7: 59-70. PMID 18202010 DOI: 10.1158/1535-7163.MCT-07-0329  0.36
2007 Gheyara AL, Vallejo-Illarramendi A, Zang K, Mei L, St-Arnaud R, Dedhar S, Reichardt LF. Deletion of integrin-linked kinase from skeletal muscles of mice resembles muscular dystrophy due to alpha 7 beta 1-integrin deficiency. The American Journal of Pathology. 171: 1966-77. PMID 18055553 DOI: 10.2353/ajpath.2007.070555  0.36
2007 Guo W, Jiang H, Gray V, Dedhar S, Rao Y. Role of the integrin-linked kinase (ILK) in determining neuronal polarity. Developmental Biology. 306: 457-68. PMID 17490631 DOI: 10.1016/j.ydbio.2007.03.019  0.36
2007 Gkretsi V, Mars WM, Bowen WC, Barua L, Yang Y, Guo L, St-Arnaud R, Dedhar S, Wu C, Michalopoulos GK. Loss of integrin linked kinase from mouse hepatocytes in vitro and in vivo results in apoptosis and hepatitis. Hepatology (Baltimore, Md.). 45: 1025-34. PMID 17385211 DOI: 10.1002/hep.21540  0.36
2007 Thompson EW, Savagner P, Dedhar S, Kalluri R. Epithelial-mesenchymal transitions - New insights into signaling, development and pathogenesis Cells Tissues Organs. 185: 5-6. DOI: 10.1159/000104413  0.36
2006 Naska S, Park KJ, Hannigan GE, Dedhar S, Miller FD, Kaplan DR. An essential role for the integrin-linked kinase-glycogen synthase kinase-3 beta pathway during dendrite initiation and growth. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 26: 13344-56. PMID 17182785 DOI: 10.1523/JNEUROSCI.4462-06.2006  0.36
2006 White DE, Coutu P, Shi YF, Tardif JC, Nattel S, St Arnaud R, Dedhar S, Muller WJ. Targeted ablation of ILK from the murine heart results in dilated cardiomyopathy and spontaneous heart failure. Genes & Development. 20: 2355-60. PMID 16951252 DOI: 10.1101/gad.1458906  0.36
2006 Dai C, Stolz DB, Bastacky SI, St-Arnaud R, Wu C, Dedhar S, Liu Y. Essential role of integrin-linked kinase in podocyte biology: Bridging the integrin and slit diaphragm signaling. Journal of the American Society of Nephrology : Jasn. 17: 2164-75. PMID 16837631 DOI: 10.1681/ASN.2006010033  0.36
2006 Zhou FQ, Walzer M, Wu YH, Zhou J, Dedhar S, Snider WD. Neurotrophins support regenerative axon assembly over CSPGs by an ECM-integrin-independent mechanism. Journal of Cell Science. 119: 2787-96. PMID 16772333 DOI: 10.1242/jcs.03016  0.36
2006 Bertram J, Peacock JW, Tan C, Mui AL, Chung SW, Gleave ME, Dedhar S, Cox ME, Ong CJ. Inhibition of the phosphatidylinositol 3'-kinase pathway promotes autocrine Fas-induced death of phosphatase and tensin homologue-deficient prostate cancer cells. Cancer Research. 66: 4781-8. PMID 16651432 DOI: 10.1158/0008-5472.CAN-05-3173  0.36
2006 El-Aouni C, Herbach N, Blattner SM, Henger A, Rastaldi MP, Jarad G, Miner JH, Moeller MJ, St-Arnaud R, Dedhar S, Holzman LB, Wanke R, Kretzler M. Podocyte-specific deletion of integrin-linked kinase results in severe glomerular basement membrane alterations and progressive glomerulosclerosis. Journal of the American Society of Nephrology : Jasn. 17: 1334-44. PMID 16611717 DOI: 10.1681/ASN.2005090921  0.36
2006 Lee JM, Dedhar S, Kalluri R, Thompson EW. The epithelial-mesenchymal transition: new insights in signaling, development, and disease. The Journal of Cell Biology. 172: 973-81. PMID 16567498 DOI: 10.1083/jcb.200601018  0.36
2006 Edwards LA, Verreault M, Thiessen B, Dragowska WH, Hu Y, Yeung JH, Dedhar S, Bally MB. Combined inhibition of the phosphatidylinositol 3-kinase/Akt and Ras/mitogen-activated protein kinase pathways results in synergistic effects in glioblastoma cells. Molecular Cancer Therapeutics. 5: 645-54. PMID 16546979 DOI: 10.1158/1535-7163.MCT-05-0099  0.36
2006 Mills J, Niewmierzycka A, Oloumi A, Rico B, St-Arnaud R, Mackenzie IR, Mawji NM, Wilson J, Reichardt LF, Dedhar S. Critical role of integrin-linked kinase in granule cell precursor proliferation and cerebellar development. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 26: 830-40. PMID 16421303 DOI: 10.1523/JNEUROSCI.1852-05.2006  0.36
2006 Troussard AA, McDonald PC, Wederell ED, Mawji NM, Filipenko NR, Gelmon KA, Kucab JE, Dunn SE, Emerman JT, Bally MB, Dedhar S. Preferential dependence of breast cancer cells versus normal cells on integrin-linked kinase for protein kinase B/Akt activation and cell survival. Cancer Research. 66: 393-403. PMID 16397254 DOI: 10.1158/0008-5472.CAN-05-2304  0.36
2006 Ahmed N, Maines-Bandiera S, Quinn MA, Unger WG, Dedhar S, Auersperg N. Molecular pathways regulating EGF-induced epithelio-mesenchymal transition in human ovarian surface epithelium. American Journal of Physiology. Cell Physiology. 290: C1532-42. PMID 16394028 DOI: 10.1152/ajpcell.00478.2005  0.36
2005 Chen H, Huang XN, Yan W, Chen K, Guo L, Tummalapali L, Dedhar S, St-Arnaud R, Wu C, Sepulveda JL. Role of the integrin-linked kinase/PINCH1/alpha-parvin complex in cardiac myocyte hypertrophy. Laboratory Investigation; a Journal of Technical Methods and Pathology. 85: 1342-56. PMID 16170337 DOI: 10.1038/labinvest.3700345  0.36
2005 Mulholland DJ, Dedhar S, Coetzee GA, Nelson CC. Interaction of nuclear receptors with the Wnt/beta-catenin/Tcf signaling axis: Wnt you like to know? Endocrine Reviews. 26: 898-915. PMID 16126938 DOI: 10.1210/er.2003-0034  0.36
2005 Barker TH, Baneyx G, Cardó-Vila M, Workman GA, Weaver M, Menon PM, Dedhar S, Rempel SA, Arap W, Pasqualini R, Vogel V, Sage EH. SPARC regulates extracellular matrix organization through its modulation of integrin-linked kinase activity. The Journal of Biological Chemistry. 280: 36483-93. PMID 16115889 DOI: 10.1074/jbc.M504663200  0.36
2005 Niewmierzycka A, Mills J, St-Arnaud R, Dedhar S, Reichardt LF. Integrin-linked kinase deletion from mouse cortex results in cortical lamination defects resembling cobblestone lissencephaly. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 25: 7022-31. PMID 16049178 DOI: 10.1523/JNEUROSCI.1695-05.2005  0.36
2005 Filipenko NR, Attwell S, Roskelley C, Dedhar S. Integrin-linked kinase activity regulates Rac- and Cdc42-mediated actin cytoskeleton reorganization via alpha-PIX. Oncogene. 24: 5837-49. PMID 15897874 DOI: 10.1038/sj.onc.1208737  0.56
2005 Sutherland BW, Kucab J, Wu J, Lee C, Cheang MC, Yorida E, Turbin D, Dedhar S, Nelson C, Pollak M, Leighton Grimes H, Miller K, Badve S, Huntsman D, Blake-Gilks C, et al. Akt phosphorylates the Y-box binding protein 1 at Ser102 located in the cold shock domain and affects the anchorage-independent growth of breast cancer cells. Oncogene. 24: 4281-92. PMID 15806160 DOI: 10.1038/sj.onc.1208590  0.36
2005 Edwards LA, Thiessen B, Dragowska WH, Daynard T, Bally MB, Dedhar S. Inhibition of ILK in PTEN-mutant human glioblastomas inhibits PKB/Akt activation, induces apoptosis, and delays tumor growth. Oncogene. 24: 3596-605. PMID 15782140 DOI: 10.1038/sj.onc.1208427  0.36
2005 Qian Y, Zhong X, Flynn DC, Zheng JZ, Qiao M, Wu C, Dedhar S, Shi X, Jiang BH. ILK mediates actin filament rearrangements and cell migration and invasion through PI3K/Akt/Rac1 signaling. Oncogene. 24: 3154-65. PMID 15735674 DOI: 10.1038/sj.onc.1208525  0.36
2004 Barberà MJ, Puig I, Domínguez D, Julien-Grille S, Guaita-Esteruelas S, Peiró S, Baulida J, Francí C, Dedhar S, Larue L, García de Herreros A. Regulation of Snail transcription during epithelial to mesenchymal transition of tumor cells. Oncogene. 23: 7345-54. PMID 15286702 DOI: 10.1038/sj.onc.1207990  0.36
2004 Zhou FQ, Zhou J, Dedhar S, Wu YH, Snider WD. NGF-induced axon growth is mediated by localized inactivation of GSK-3beta and functions of the microtubule plus end binding protein APC. Neuron. 42: 897-912. PMID 15207235 DOI: 10.1016/j.neuron.2004.05.011  0.36
2004 Edwards LA, Shabbits JA, Bally M, Dedhar S. Integrin-linked kinase (ILK) in combination molecular targeting. Cancer Treatment and Research. 119: 59-75. PMID 15164873 DOI: 10.1007/1-4020-7847-1_4  0.36
2004 McHardy LM, Sinotte R, Troussard A, Sheldon C, Church J, Williams DE, Andersen RJ, Dedhar S, Roberge M, Roskelley CD. The tumor invasion inhibitor dihydromotuporamine C activates RHO, remodels stress fibers and focal adhesions, and stimulates sodium-proton exchange. Cancer Research. 64: 1468-74. PMID 14973060 DOI: 10.1158/0008-5472.CAN-03-2733  0.36
2004 Tan C, Cruet-Hennequart S, Troussard A, Fazli L, Costello P, Sutton K, Wheeler J, Gleave M, Sanghera J, Dedhar S. Regulation of tumor angiogenesis by integrin-linked kinase (ILK). Cancer Cell. 5: 79-90. PMID 14749128  0.36
2003 Attwell S, Mills J, Troussard A, Wu C, Dedhar S. Integration of cell attachment, cytoskeletal localization, and signaling by integrin-linked kinase (ILK), CH-ILKBP, and the tumor suppressor PTEN. Molecular Biology of the Cell. 14: 4813-25. PMID 12960424 DOI: 10.1091/mbc.E03-05-0308  0.56
2003 Persad S, Dedhar S. The role of integrin-linked kinase (ILK) in cancer progression. Cancer Metastasis Reviews. 22: 375-84. PMID 12884912 DOI: 10.1023/A:1023777013659  0.36
2003 Terpstra L, Prud'homme J, Arabian A, Takeda S, Karsenty G, Dedhar S, St-Arnaud R. Reduced chondrocyte proliferation and chondrodysplasia in mice lacking the integrin-linked kinase in chondrocytes. The Journal of Cell Biology. 162: 139-48. PMID 12835312 DOI: 10.1083/jcb.200302066  0.36
2003 Troussard AA, Mawji NM, Ong C, Mui A, St -Arnaud R, Dedhar S. Conditional knock-out of integrin-linked kinase demonstrates an essential role in protein kinase B/Akt activation. The Journal of Biological Chemistry. 278: 22374-8. PMID 12686550 DOI: 10.1074/jbc.M303083200  0.36
2003 Mills J, Digicaylioglu M, Legg AT, Young CE, Young SS, Barr AM, Fletcher L, O'Connor TP, Dedhar S. Role of integrin-linked kinase in nerve growth factor-stimulated neurite outgrowth. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 23: 1638-48. PMID 12629168  0.36
2002 Yoganathan N, Yee A, Zhang Z, Leung D, Yan J, Fazli L, Kojic DL, Costello PC, Jabali M, Dedhar S, Sanghera J. Integrin-linked kinase, a promising cancer therapeutic target: biochemical and biological properties. Pharmacology & Therapeutics. 93: 233-42. PMID 12191615 DOI: 10.1016/S0163-7258(02)00192-4  0.36
2002 Tan C, Mui A, Dedhar S. Integrin-linked kinase regulates inducible nitric oxide synthase and cyclooxygenase-2 expression in an NF-κB-dependent manner Journal of Biological Chemistry. 277: 3109-3116. PMID 11724787 DOI: 10.1074/jbc.M108673200  0.36
2001 Marotta A, Tan C, Gray V, Malik S, Gallinger S, Sanghera J, Dupuis B, Owen D, Dedhar S, Salh B. Dysregulation of integrin-linked kinase (ILK) signaling in colonic polyposis. Oncogene. 20: 6250-7. PMID 11593435 DOI: 10.1038/sj.onc.1204791  0.36
2001 Persad S, Troussard AA, McPhee TR, Mulholland DJ, Dedhar S. Tumor suppressor PTEN inhibits nuclear accumulation of β-catenin and T cell/lymphoid enhancer factor 1-mediated transcriptional activation Journal of Cell Biology. 153: 1161-1173. PMID 11402061 DOI: 10.1083/jcb.153.6.1161  0.36
2001 Persad S, Attwell S, Gray V, Mawji N, Deng JT, Leung D, Yan J, Sanghera J, Walsh MP, Dedhar S. Regulation of protein kinase B/Akt-serine 473 phosphorylation by integrin-linked kinase: critical roles for kinase activity and amino acids arginine 211 and serine 343. The Journal of Biological Chemistry. 276: 27462-9. PMID 11313365 DOI: 10.1074/jbc.M102940200  0.36
2000 Attwell S, Roskelley C, Dedhar S. The integrin-linked kinase (ILK) suppresses anoikis. Oncogene. 19: 3811-5. PMID 10949937 DOI: 10.1038/sj.onc.1203711  0.56
2000 D'Amico M, Hulit J, Amanatullah DF, Zafonte BT, Albanese C, Bouzahzah B, Fu M, Augenlicht LH, Donehower LA, Takemaru KI, Moon RT, Davis R, Lisanti MP, Shtutman M, Zhurinsky J, ... ... Dedhar S, et al. The integrated-linked kinase regulates the cyclin D1 gene through glycogen synthase kinase 3β and cAMP-responsive element-binding protein-dependent pathways Journal of Biological Chemistry. 275: 32649-32657. PMID 10915780 DOI: 10.1074/jbc.M000643200  0.36
2000 Rauch F, Prud'homme J, Arabian A, Dedhar S, St-Arnaud R. Heart, brain, and body wall defects in mice lacking calreticulin. Experimental Cell Research. 256: 105-11. PMID 10739657 DOI: 10.1006/excr.2000.4818  0.36
2000 Persad S, Attwell S, Gray V, Delcommenne M, Troussard A, Sanghera J, Dedhar S. Inhibition of integrin-linked kinase (ILK) suppresses activation of protein kinase B/Akt and induces cell cycle arrest and apoptosis of PTEN-mutant prostate cancer cells. Proceedings of the National Academy of Sciences of the United States of America. 97: 3207-12. PMID 10716737 DOI: 10.1073/pnas.060579697  0.36
1998 Wang F, Weaver VM, Petersen OW, Larabell CA, Dedhar S, Briand P, Lupu R, Bissell MJ. Reciprocal interactions between beta1-integrin and epidermal growth factor receptor in three-dimensional basement membrane breast cultures: a different perspective in epithelial biology. Proceedings of the National Academy of Sciences of the United States of America. 95: 14821-6. PMID 9843973 DOI: 10.1073/pnas.95.25.14821  0.36
1998 Novak A, Hsu SC, Leung-Hagesteijn C, Radeva G, Papkoff J, Montesano R, Roskelley C, Grosschedl R, Dedhar S. Cell adhesion and the integrin-linked kinase regulate the LEF-1 and β-catenin signaling pathways Proceedings of the National Academy of Sciences of the United States of America. 95: 4374-4379. PMID 9539744 DOI: 10.1073/PNAS.95.8.4374  0.36
1998 Wu C, Keightley SY, Leung-Hagesteijn C, Radeva G, Coppolino M, Goicoechea S, McDonald JA, Dedhar S. Integrin-linked protein kinase regulates fibronectin matrix assembly, E- cadherin expression, and tumorigenicity Journal of Biological Chemistry. 273: 528-536. PMID 9417112 DOI: 10.1074/jbc.273.1.528  0.36
1997 Radeva G, Petrocelli T, Behrend E, Leung-Hagesteijn C, Filmus J, Slingerland J, Dedhar S. Overexpression of the integrin-linked kinase promotes anchorage- independent cell cycle progression Journal of Biological Chemistry. 272: 13937-13944. PMID 9153256 DOI: 10.1074/jbc.272.21.13937  0.36
1996 Hannigan GE, Leung-Hagesteijn C, Fitz-Gibbon L, Coppolino MG, Radeva G, Filmus J, Bell JC, Dedhar S. Regulation of cell adhesion and anchorage-dependent growth by a new β1-integrin-linked protein kinase Nature. 379: 91-96. PMID 8538749 DOI: 10.1038/379091a0  0.36
1995 St-Arnaud R, Prud'homme J, Leung-Hagesteijn C, Dedhar S. Constitutive expression of calreticulin in osteoblasts inhibits mineralization. The Journal of Cell Biology. 131: 1351-9. PMID 8522595 DOI: 10.1083/jcb.131.5.1351  0.36
1994 Kruk PA, Uitto VJ, Firth JD, Dedhar S, Auersperg N. Reciprocal interactions between human ovarian surface epithelial cells and adjacent extracellular matrix Experimental Cell Research. 215: 97-108. PMID 7525326 DOI: 10.1006/excr.1994.1320  0.36
1990 Dedhar S, Gray V. Isolation of a novel integrin receptor mediating ARG-GLY-ASP-directed cell adhesion to fibronectin and type I collagen from human neuroblastoma cells. Association of a novel /β1-related subunit with αv Journal of Cell Biology. 110: 2185-2193. PMID 1693626 DOI: 10.1083/jcb.110.6.2185  0.36
1988 Pierschbacher MD, Dedhar S, Ruoslahti E, Argraves S, Suzuki S. An adhesion variant of the MG-63 osteosarcoma cell line displays an osteoblast-like phenotype Ciba Foundation Symposium. 136: 131-141. PMID 3068006 DOI: 10.1002/9780470513637.ch9  0.36
1987 Dedhar S, Ruoslahti E, Pierschbacher MD. A cell surface receptor complex for collagen type I recognizes the Arg-Gly-Asp sequence Journal of Cell Biology. 104: 585-593. PMID 3469204 DOI: 10.1083/jcb.104.3.585  0.36
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