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Dan Rudolf Littman, MD, Ph.D. - Publications

Affiliations: 
2014- Microbiology Immunology NYU Langone Medical Center 

281 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2023 Zhang B, Upadhyay R, Hao Y, Samanovic MI, Herati RS, Blair J, Axelrad J, Mulligan MJ, Littman DR, Satija R. Multimodal characterization of antigen-specific CD8 T cells across SARS-CoV-2 vaccination and infection. Biorxiv : the Preprint Server For Biology. PMID 36747786 DOI: 10.1101/2023.01.24.525203  0.305
2023 Schnell A, Littman DR, Kuchroo VK. T17 cell heterogeneity and its role in tissue inflammation. Nature Immunology. 24: 19-29. PMID 36596896 DOI: 10.1038/s41590-022-01387-9  0.328
2022 Kedmi R, Najar TA, Mesa KR, Grayson A, Kroehling L, Hao Y, Hao S, Pokrovskii M, Xu M, Talbot J, Wang J, Germino J, Lareau CA, Satpathy AT, Anderson MS, ... ... Littman DR, et al. Publisher Correction: A RORγt cell instructs gut microbiota-specific T cell differentiation. Nature. PMID 36151471 DOI: 10.1038/s41586-022-05358-w  0.305
2022 Kedmi R, Najar TA, Mesa KR, Grayson A, Kroehling L, Hao Y, Hao S, Pokrovskii M, Xu M, Talbot J, Wang J, Germino J, Lareau CA, Satpathy AT, Anderson MS, ... ... Littman DR, et al. A RORγt cell instructs gut microbiota-specific T cell differentiation. Nature. PMID 36071167 DOI: 10.1038/s41586-022-05089-y  0.358
2022 Teghanemt A, Pulipati P, Misel-Wuchter K, Day K, Yorek MS, Yi R, Keen HL, Au C, Maretzky T, Gurung P, Littman DR, Issuree PD. CD4 expression in effector T cells depends on DNA demethylation over a developmentally established stimulus-responsive element. Nature Communications. 13: 1477. PMID 35304452 DOI: 10.1038/s41467-022-28914-4  0.335
2020 Sagar, Pokrovskii M, Herman JS, Naik S, Sock E, Zeis P, Lausch U, Wegner M, Tanriver Y, Littman DR, Grün D. Deciphering the regulatory landscape of fetal and adult γδ T-cell development at single-cell resolution. The Embo Journal. 39: e104159. PMID 32627520 DOI: 10.15252/Embj.2019104159  0.433
2019 Lee JY, Hall JA, Kroehling L, Wu L, Najar T, Nguyen HH, Lin WY, Yeung ST, Silva HM, Li D, Hine A, Loke P, Hudesman D, Martin JC, Kenigsberg E, ... ... Littman DR, et al. Serum Amyloid A Proteins Induce Pathogenic Th17 Cells and Promote Inflammatory Disease. Cell. PMID 31866067 DOI: 10.1016/j.cell.2019.11.026  0.334
2019 Hang S, Paik D, Yao L, Kim E, Jamma T, Lu J, Ha S, Nelson BN, Kelly SP, Wu L, Zheng Y, Longman RS, Rastinejad F, Devlin AS, Krout MR, ... ... Littman DR, et al. Bile acid metabolites control T17 and T cell differentiation. Nature. PMID 31776512 DOI: 10.1038/S41586-019-1785-Z  0.445
2019 Pokrovskii M, Hall JA, Ochayon DE, Yi R, Chaimowitz NS, Seelamneni H, Carriero N, Watters A, Waggoner SN, Littman DR, Bonneau R, Miraldi ER. Characterization of Transcriptional Regulatory Networks that Promote and Restrict Identities and Functions of Intestinal Innate Lymphoid Cells. Immunity. PMID 31278058 DOI: 10.1016/J.Immuni.2019.06.001  0.328
2019 Ng C, Aichinger M, Nguyen T, Au C, Najar T, Wu L, Mesa KR, Liao W, Quivy JP, Hubert B, Almouzni G, Zuber J, Littman DR. The histone chaperone CAF-1 cooperates with the DNA methyltransferases to maintain silencing in cytotoxic T cells. Genes & Development. PMID 30975723 DOI: 10.1101/Gad.322024.118  0.369
2019 Xu M, Pokrovskii M, Ding Y, Yi R, Au C, Harrison OJ, Galan C, Belkaid Y, Bonneau R, Littman DR. Author Correction: c-MAF-dependent regulatory T cells mediate immunological tolerance to a gut pathobiont. Nature. PMID 30723268 DOI: 10.1038/S41586-019-0922-Z  0.318
2019 Miraldi ER, Pokrovskii M, Waters A, Castro DM, De Veaux N, Hall J, Lee JY, Ciofani M, Madar A, Carriero N, Littman D, Bonneau R. Leveraging chromatin accessibility for transcriptional regulatory network inference in T Helper 17 Cells. Genome Research. PMID 30696696 DOI: 10.1101/Gr.238253.118  0.33
2019 Xu H, Littman D, Huang W. Abstract B198: Dissection of RORγt functions in lymphoid cell fate determination and differentiation Cancer Immunology Research. 7. DOI: 10.1158/2326-6074.Cricimteatiaacr18-B198  0.478
2019 Kedmi R, Mesa K, Littman D. Abstract B167: Antigen-presenting cells as coordinators of T-cell responses to gut microbiota Cancer Immunology Research. 7. DOI: 10.1158/2326-6074.Cricimteatiaacr18-B167  0.454
2018 Issuree PD, Day K, Au C, Raviram R, Zappile P, Skok JA, Xue HH, Myers RM, Littman DR. Stage-specific epigenetic regulation of CD4 expression by coordinated enhancer elements during T cell development. Nature Communications. 9: 3594. PMID 30185805 DOI: 10.1038/S41467-018-05834-W  0.437
2018 Kim M, Galan C, Hill AA, Wu WJ, Fehlner-Peach H, Song HW, Schady D, Bettini ML, Simpson KW, Longman RS, Littman DR, Diehl GE. Critical Role for the Microbiota in CXCR1 Intestinal Mononuclear Phagocyte Regulation of Intestinal T Cell Responses. Immunity. PMID 29980437 DOI: 10.1016/J.Immuni.2018.05.009  0.402
2018 Johnson JS, Lucas SY, Amon LM, Skelton S, Nazitto R, Carbonetti S, Sather DN, Littman DR, Aderem A. Reshaping of the Dendritic Cell Chromatin Landscape and Interferon Pathways during HIV Infection. Cell Host & Microbe. 23: 366-381.e9. PMID 29544097 DOI: 10.1016/J.Chom.2018.01.012  0.335
2018 Xu M, Pokrovskii M, Ding Y, Yi R, Au C, Harrison OJ, Galan C, Belkaid Y, Bonneau R, Littman DR. c-MAF-dependent regulatory T cells mediate immunological tolerance to a gut pathobiont. Nature. PMID 29414937 DOI: 10.1038/Nature25500  0.457
2017 Bradley CP, Teng F, Felix KM, Sano T, Naskar D, Block KE, Huang H, Knox KS, Littman DR, Wu HJ. Segmented Filamentous Bacteria Provoke Lung Autoimmunity by Inducing Gut-Lung Axis Th17 Cells Expressing Dual TCRs. Cell Host & Microbe. 22: 697-704.e4. PMID 29120746 DOI: 10.1016/J.Chom.2017.10.007  0.3
2017 Kim S, Kim H, Yim YS, Ha S, Atarashi K, Tan TG, Longman RS, Honda K, Littman DR, Choi GB, Huh JR. Maternal gut bacteria promote neurodevelopmental abnormalities in mouse offspring. Nature. PMID 28902840 DOI: 10.1038/Nature23910  0.727
2017 Shin Yim Y, Park A, Berrios J, Lafourcade M, Pascual LM, Soares N, Yeon Kim J, Kim S, Kim H, Waisman A, Littman DR, Wickersham IR, Harnett MT, Huh JR, Choi GB. Reversing behavioural abnormalities in mice exposed to maternal inflammation. Nature. PMID 28902835 DOI: 10.1038/Nature23909  0.684
2017 Issuree PD, Ng CP, Littman DR. Heritable Gene Regulation in the CD4:CD8 T Cell Lineage Choice. Frontiers in Immunology. 8: 291. PMID 28382035 DOI: 10.3389/Fimmu.2017.00291  0.441
2017 Cheung KL, Zhang F, Jaganathan A, Sharma R, Zhang Q, Konuma T, Shen T, Lee JY, Ren C, Chen CH, Lu G, Olson MR, Zhang W, Kaplan MH, Littman DR, et al. Distinct Roles of Brd2 and Brd4 in Potentiating the Transcriptional Program for Th17 Cell Differentiation. Molecular Cell. PMID 28262505 DOI: 10.1016/J.Molcel.2016.12.022  0.351
2017 Karwacz K, Miraldi ER, Pokrovskii M, Madi A, Yosef N, Wortman I, Chen X, Watters A, Carriero N, Awasthi A, Regev A, Bonneau R, Littman D, Kuchroo VK. Critical role of IRF1 and BATF in forming chromatin landscape during type 1 regulatory cell differentiation. Nature Immunology. PMID 28166218 DOI: 10.1038/Ni.3683  0.397
2016 Coffre M, Benhamou D, Rieß D, Blumenberg L, Snetkova V, Hines MJ, Chakraborty T, Bajwa S, Jensen K, Chong MM, Getu L, Silverman GJ, Blelloch R, Littman DR, Calado D, et al. miRNAs Are Essential for the Regulation of the PI3K/AKT/FOXO Pathway and Receptor Editing during B Cell Maturation. Cell Reports. 17: 2271-2285. PMID 27880903 DOI: 10.1016/J.Celrep.2016.11.006  0.496
2016 Honda K, Littman DR. The microbiota in adaptive immune homeostasis and disease. Nature. 535: 75-84. PMID 27383982 DOI: 10.1038/Nature18848  0.386
2016 Ng CP, Littman DR. Tcf1 and Lef1 pack their own HDAC. Nature Immunology. 17: 615-6. PMID 27196513 DOI: 10.1038/Ni.3469  0.419
2016 Huang W, Littman DR. Regulation of RORγt in Inflammatory Lymphoid Cell Differentiation. Cold Spring Harbor Symposia On Quantitative Biology. PMID 26968628 DOI: 10.1101/Sqb.2015.80.027615  0.455
2016 Littman DR. How Thymocytes Achieve Their Fate. Journal of Immunology (Baltimore, Md. : 1950). 196: 1983-4. PMID 26896481 DOI: 10.4049/Jimmunol.1600032  0.439
2016 Ménager MM, Littman DR. Actin Dynamics Regulates Dendritic Cell-Mediated Transfer of HIV-1 to T Cells. Cell. PMID 26830877 DOI: 10.1016/J.Cell.2015.12.036  0.397
2016 Choi GB, Yim YS, Wong H, Kim S, Kim H, Kim SV, Hoeffer CA, Littman DR, Huh JR. The maternal interleukin-17a pathway in mice promotes autismlike phenotypes in offspring. Science (New York, N.Y.). PMID 26822608 DOI: 10.1126/Science.Aad0314  0.721
2016 Huang W, Thomas B, Flynn RA, Gavzy SJ, Wu L, Kim SV, Hall JA, Miraldi ER, Ng CP, Rigo F, Meadows S, Montoya NR, Herrera NG, Domingos AI, Rastinejad F, ... ... Littman DR, et al. Corrigendum: DDX5 and its associated lncRNA Rmrp modulate TH17 cell effector functions. Nature. PMID 26789242 DOI: 10.1038/Nature16968  0.336
2016 Xu M, Littman DR. Abstract A098: Helicobacter-specific T cell responses in gut homeostasis and disease Cancer Immunology Research. 4. DOI: 10.1158/2326-6074.Cricimteatiaacr15-A098  0.397
2016 Sano T, Xu M, Wu L, Lee J, Huang W, Yang Y, Diehl G, Littman DR. Abstract IA09: The commensal microbiota as instructors and arbiters of homeostatic and pathogenic immune responses Cancer Immunology Research. 4. DOI: 10.1158/2326-6066.Imm2016-Ia09  0.479
2016 Xu M, Yang Y, Pokrovskii M, Galan C, Littman DR. Abstract A080: Balance of commensal bacteria specific Th17 and RORγt+ Treg cells in intestinal homeostasis and inflammation Cancer Immunology Research. 4. DOI: 10.1158/2326-6066.Imm2016-A080  0.399
2016 Issuree P, Day K, Littman DR. Abstract A073: Epigenetic regulation of the Cd4 locus Cancer Immunology Research. 4. DOI: 10.1158/2326-6066.Imm2016-A073  0.413
2015 Huang W, Thomas B, Flynn RA, Gavzy SJ, Wu L, Kim SV, Hall JA, Miraldi ER, Ng CP, Rigo FW, Meadows S, Montoya NR, Herrera NG, Domingos AI, Rastinejad F, ... ... Littman DR, et al. DDX5 and its associated lncRNA Rmrp modulate TH17 cell effector functions. Nature. PMID 26675721 DOI: 10.1038/Nature16193  0.331
2015 Sano T, Huang W, Hall JA, Yang Y, Chen A, Gavzy SJ, Lee JY, Ziel JW, Miraldi ER, Domingos AI, Bonneau R, Littman DR. An IL-23R/IL-22 Circuit Regulates Epithelial Serum Amyloid A to Promote Local Effector Th17 Responses. Cell. PMID 26411290 DOI: 10.1016/J.Cell.2015.08.061  0.389
2015 Pitt LA, Tikhonova AN, Hu H, Trimarchi T, King B, Gong Y, Sanchez-Martin M, Tsirigos A, Littman DR, Ferrando AA, Morrison SJ, Fooksman DR, Aifantis I, Schwab SR. CXCL12-Producing Vascular Endothelial Niches Control Acute T Cell Leukemia Maintenance. Cancer Cell. 27: 755-68. PMID 26058075 DOI: 10.1016/J.Ccell.2015.05.002  0.389
2015 Sellars M, Huh JR, Day K, Issuree PD, Galan C, Gobeil S, Absher D, Green MR, Littman DR. Regulation of DNA methylation dictates Cd4 expression during the development of helper and cytotoxic T cell lineages. Nature Immunology. 16: 746-54. PMID 26030024 DOI: 10.1038/Ni.3198  0.44
2015 Lim HW, Kang SG, Ryu JK, Schilling B, Fei M, Lee IS, Kehasse A, Shirakawa K, Yokoyama M, Schnölzer M, Kasler HG, Kwon HS, Gibson BW, Sato H, Akassoglou K, ... ... Littman DR, et al. SIRT1 deacetylates RORγt and enhances Th17 cell generation. The Journal of Experimental Medicine. 212: 607-17. PMID 25918343 DOI: 10.1084/Jem.20132378  0.423
2015 Santori FR, Huang P, van de Pavert SA, Douglass EF, Leaver DJ, Haubrich BA, Keber R, Lorbek G, Konijn T, Rosales BN, Rozman D, Horvat S, Rahier A, Mebius RE, Rastinejad F, ... ... Littman DR, et al. Identification of natural RORγ ligands that regulate the development of lymphoid cells. Cell Metabolism. 21: 286-97. PMID 25651181 DOI: 10.1016/J.Cmet.2015.01.004  0.768
2015 Pitt LA, Tikhonova AN, Trimarchi T, King B, Hu H, Gong Y, Tsirigos A, Sanchez-Martin M, Littman DR, Ferrando A, Morrison SJ, Fooksman DR, Aifantis I, Schwab S. Abstract A06: The chemokine receptor CXCR4 is essential for the maintenance of T cell acute lymphoblastic leukemia. Clinical Cancer Research. 21. DOI: 10.1158/1557-3265.Hemmal14-A06  0.43
2014 Longman RS, Diehl GE, Victorio DA, Huh JR, Galan C, Miraldi ER, Swaminath A, Bonneau R, Scherl EJ, Littman DR. CX₃CR1⁺ mononuclear phagocytes support colitis-associated innate lymphoid cell production of IL-22. The Journal of Experimental Medicine. 211: 1571-83. PMID 25024136 DOI: 10.1084/Jem.20140678  0.328
2014 Yang Y, Torchinsky MB, Gobert M, Xiong H, Xu M, Linehan JL, Alonzo F, Ng C, Chen A, Lin X, Sczesnak A, Liao JJ, Torres VJ, Jenkins MK, Lafaille JJ, ... Littman DR, et al. Focused specificity of intestinal TH17 cells towards commensal bacterial antigens. Nature. 510: 152-6. PMID 24739972 DOI: 10.1038/Nature13279  0.476
2013 Longman RS, Yang Y, Diehl GE, Kim SV, Littman DR. Microbiota: host interactions in mucosal homeostasis and systemic autoimmunity. Cold Spring Harbor Symposia On Quantitative Biology. 78: 193-201. PMID 24913313 DOI: 10.1101/Sqb.2013.78.020081  0.417
2013 Kruglov AA, Grivennikov SI, Kuprash DV, Winsauer C, Prepens S, Seleznik GM, Eberl G, Littman DR, Heikenwalder M, Tumanov AV, Nedospasov SA. Nonredundant function of soluble LTα3 produced by innate lymphoid cells in intestinal homeostasis. Science (New York, N.Y.). 342: 1243-6. PMID 24311691 DOI: 10.1126/Science.1243364  0.389
2013 Huh JR, Englund EE, Wang H, Huang R, Huang P, Rastinejad F, Inglese J, Austin CP, Johnson RL, Huang W, Littman DR. Identification of Potent and Selective Diphenylpropanamide RORγ Inhibitors. Acs Medicinal Chemistry Letters. 4: 79-84. PMID 24040486 DOI: 10.1021/Ml300286H  0.356
2013 Seay K, Qi X, Zheng JH, Zhang C, Chen K, Dutta M, Deneroff K, Ochsenbauer C, Kappes JC, Littman DR, Goldstein H. Mice transgenic for CD4-specific human CD4, CCR5 and cyclin T1 expression: a new model for investigating HIV-1 transmission and treatment efficacy. Plos One. 8: e63537. PMID 23691059 DOI: 10.1371/Journal.Pone.0063537  0.345
2013 Kim SV, Xiang WV, Kwak C, Yang Y, Lin XW, Ota M, Sarpel U, Rifkin DB, Xu R, Littman DR. GPR15-mediated homing controls immune homeostasis in the large intestine mucosa. Science (New York, N.Y.). 340: 1456-9. PMID 23661644 DOI: 10.1126/Science.1237013  0.414
2013 Streeck H, D'Souza MP, Littman DR, Crotty S. Harnessing CD4⁺ T cell responses in HIV vaccine development. Nature Medicine. 19: 143-9. PMID 23389614 DOI: 10.1038/Nm.3054  0.445
2013 Diehl GE, Longman RS, Zhang JX, Breart B, Galan C, Cuesta A, Schwab SR, Littman DR. Microbiota restricts trafficking of bacteria to mesenteric lymph nodes by CX(3)CR1(hi) cells. Nature. 494: 116-20. PMID 23334413 DOI: 10.1038/Nature11809  0.348
2013 Longman RS, Diehl G, Swaminath A, Huh J, Scherl EJ, Littman DR. 23 TLR/MYD88-Dependent Production of Il1β and IL-23 by Intestinal Dendritic Cells Support Increased Ilc Production of IL-22 in IBD Gastroenterology. 144: S-7. DOI: 10.1016/S0016-5085(13)60019-0  0.356
2012 Ciofani M, Madar A, Galan C, Sellars M, Mace K, Pauli F, Agarwal A, Huang W, Parkurst CN, Muratet M, Newberry KM, Meadows S, Greenfield A, Yang Y, Jain P, ... ... Littman DR, et al. A validated regulatory network for Th17 cell specification. Cell. 151: 289-303. PMID 23021777 DOI: 10.1016/J.Cell.2012.09.016  0.363
2012 Glasmacher E, Agrawal S, Chang AB, Murphy TL, Zeng W, Vander Lugt B, Khan AA, Ciofani M, Spooner CJ, Rutz S, Hackney J, Nurieva R, Escalante CR, Ouyang W, Littman DR, et al. A genomic regulatory element that directs assembly and function of immune-specific AP-1-IRF complexes. Science (New York, N.Y.). 338: 975-80. PMID 22983707 DOI: 10.1126/Science.1228309  0.377
2012 Weiss JM, Bilate AM, Gobert M, Ding Y, Curotto de Lafaille MA, Parkhurst CN, Xiong H, Dolpady J, Frey AB, Ruocco MG, Yang Y, Floess S, Huehn J, Oh S, Li MO, ... ... Littman DR, et al. Neuropilin 1 is expressed on thymus-derived natural regulatory T cells, but not mucosa-generated induced Foxp3+ T reg cells. The Journal of Experimental Medicine. 209: 1723-42, S1. PMID 22966001 DOI: 10.1084/Jem.20120914  0.449
2012 Huh JR, Littman DR. Small molecule inhibitors of RORγt: targeting Th17 cells and other applications. European Journal of Immunology. 42: 2232-7. PMID 22949321 DOI: 10.1002/Eji.201242740  0.424
2012 Fulton LM, Carlson MJ, Coghill JM, Ott LE, West ML, Panoskaltsis-Mortari A, Littman DR, Blazar BR, Serody JS. Attenuation of acute graft-versus-host disease in the absence of the transcription factor RORγt. Journal of Immunology (Baltimore, Md. : 1950). 189: 1765-72. PMID 22778391 DOI: 10.4049/Jimmunol.1200858  0.451
2012 Xu C, Shen Y, Littman DR, Dustin ML, Velázquez P. Visualization of mucosal homeostasis via single- and multiphoton intravital fluorescence microscopy. Journal of Leukocyte Biology. 92: 413-9. PMID 22457365 DOI: 10.1189/Jlb.0711344  0.414
2012 Kinnebrew MA, Buffie CG, Diehl GE, Zenewicz LA, Leiner I, Hohl TM, Flavell RA, Littman DR, Pamer EG. Interleukin 23 production by intestinal CD103(+)CD11b(+) dendritic cells in response to bacterial flagellin enhances mucosal innate immune defense. Immunity. 36: 276-87. PMID 22306017 DOI: 10.1016/J.Immuni.2011.12.011  0.359
2012 Gialitakis M, Sellars M, Littman DR. The epigenetic landscape of lineage choice: lessons from the heritability of CD4 and CD8 expression. Current Topics in Microbiology and Immunology. 356: 165-88. PMID 21989924 DOI: 10.1007/82_2011_175  0.463
2012 Longman R, Diehl G, Swaminath A, Scherl E, Littman D. Microbial Regulation of CD141 Human Intestinal DCs Support ILC Production of IL-22 in IBD Inflammatory Bowel Diseases. 18: S107-S108. DOI: 10.1097/00054725-201212001-00274  0.352
2012 Longman R, Diehl G, Swaminath A, Scherl E, Littman D. Microbial Regulation of CD14+ Human Intestinal DCs Support ILC Production of IL-22 in IBD Inflammatory Bowel Diseases. 18: S11. DOI: 10.1097/00054725-201212001-00026  0.352
2012 Longman RS, Swaminath A, Diehl G, Sczesnak A, Honig G, Scherl EJ, Littman DR. 866 Microbiota Support Increased Production of IL-22 by Lamina Propria Innate Lymphoid Cells in Patients With IBD Gastroenterology. 142: S-149. DOI: 10.1016/S0016-5085(12)60562-9  0.311
2011 Manel N, Littman DR. Hiding in plain sight: how HIV evades innate immune responses. Cell. 147: 271-4. PMID 22000008 DOI: 10.1016/J.Cell.2011.09.010  0.32
2011 Sczesnak A, Segata N, Qin X, Gevers D, Petrosino JF, Huttenhower C, Littman DR, Ivanov II. The genome of th17 cell-inducing segmented filamentous bacteria reveals extensive auxotrophy and adaptations to the intestinal environment. Cell Host & Microbe. 10: 260-72. PMID 21925113 DOI: 10.1016/J.Chom.2011.08.005  0.314
2011 Egawa T, Littman DR. Transcription factor AP4 modulates reversible and epigenetic silencing of the Cd4 gene. Proceedings of the National Academy of Sciences of the United States of America. 108: 14873-8. PMID 21873191 DOI: 10.1073/Pnas.1112293108  0.411
2011 Sujino T, Kanai T, Ono Y, Mikami Y, Hayashi A, Doi T, Matsuoka K, Hisamatsu T, Takaishi H, Ogata H, Yoshimura A, Littman DR, Hibi T. Regulatory T cells suppress development of colitis, blocking differentiation of T-helper 17 into alternative T-helper 1 cells. Gastroenterology. 141: 1014-23. PMID 21699791 DOI: 10.1053/J.Gastro.2011.05.052  0.443
2011 Huh JR, Leung MW, Huang P, Ryan DA, Krout MR, Malapaka RR, Chow J, Manel N, Ciofani M, Kim SV, Cuesta A, Santori FR, Lafaille JJ, Xu HE, Gin DY, ... ... Littman DR, et al. Digoxin and its derivatives suppress TH17 cell differentiation by antagonizing RORγt activity. Nature. 472: 486-90. PMID 21441909 DOI: 10.1038/Nature09978  0.473
2011 Collins A, Hewitt SL, Chaumeil J, Sellars M, Micsinai M, Allinne J, Parisi F, Nora EP, Bolland DJ, Corcoran AE, Kluger Y, Bosselut R, Ellmeier W, Chong MM, Littman DR, et al. RUNX transcription factor-mediated association of Cd4 and Cd8 enables coordinate gene regulation. Immunity. 34: 303-14. PMID 21435585 DOI: 10.1016/J.Immuni.2011.03.004  0.386
2011 Hovhannisyan Z, Treatman J, Littman DR, Mayer L. Characterization of interleukin-17-producing regulatory T cells in inflamed intestinal mucosa from patients with inflammatory bowel diseases. Gastroenterology. 140: 957-65. PMID 21147109 DOI: 10.1053/J.Gastro.2010.12.002  0.448
2010 Manel N, Hogstad B, Wang Y, Levy DE, Unutmaz D, Littman DR. A cryptic sensor for HIV-1 activates antiviral innate immunity in dendritic cells. Nature. 467: 214-7. PMID 20829794 DOI: 10.1038/Nature09337  0.382
2010 Wu HJ, Ivanov II, Darce J, Hattori K, Shima T, Umesaki Y, Littman DR, Benoist C, Mathis D. Gut-residing segmented filamentous bacteria drive autoimmune arthritis via T helper 17 cells. Immunity. 32: 815-27. PMID 20620945 DOI: 10.1016/J.Immuni.2010.06.001  0.419
2010 Buonocore S, Ahern PP, Uhlig HH, Ivanov II, Littman DR, Maloy KJ, Powrie F. Innate lymphoid cells drive interleukin-23-dependent innate intestinal pathology. Nature. 464: 1371-5. PMID 20393462 DOI: 10.1038/Nature08949  0.376
2010 Chong MM, Simpson N, Ciofani M, Chen G, Collins A, Littman DR. Epigenetic propagation of CD4 expression is established by the Cd4 proximal enhancer in helper T cells. Genes & Development. 24: 659-69. PMID 20360383 DOI: 10.1101/Gad.1901610  0.442
2010 Littman DR, Rudensky AY. Th17 and regulatory T cells in mediating and restraining inflammation. Cell. 140: 845-58. PMID 20303875 DOI: 10.1016/J.Cell.2010.02.021  0.373
2010 Ivanov II, Littman DR. Segmented filamentous bacteria take the stage. Mucosal Immunology. 3: 209-12. PMID 20147894 DOI: 10.1038/Mi.2010.3  0.419
2010 El Hed A, Khaitan A, Kozhaya L, Manel N, Daskalakis D, Borkowsky W, Valentine F, Littman DR, Unutmaz D. Susceptibility of human Th17 cells to human immunodeficiency virus and their perturbation during infection. The Journal of Infectious Diseases. 201: 843-54. PMID 20144043 DOI: 10.1086/651021  0.365
2010 Trampont PC, Tosello-Trampont AC, Shen Y, Duley AK, Sutherland AE, Bender TP, Littman DR, Ravichandran KS. CXCR4 acts as a costimulator during thymic beta-selection. Nature Immunology. 11: 162-70. PMID 20010845 DOI: 10.1038/Ni.1830  0.378
2010 Jacob B, Osato M, Yamashita N, Wang CQ, Taniuchi I, Littman DR, Asou N, Ito Y. Stem cell exhaustion due to Runx1 deficiency is prevented by Evi5 activation in leukemogenesis. Blood. 115: 1610-20. PMID 20008790 DOI: 10.1182/Blood-2009-07-232249  0.337
2010 Fulton LM, Carlson MJ, Coghill J, West ML, Panoskaltisis-Mortari A, Blazar BR, Littman D, Serody J. Attenuated Acute Graft-Versus-Host Disease Following Allogeneic Stem Cell Transplantation In the Absence of RORγt. Blood. 116: 3742-3742. DOI: 10.1182/Blood.V116.21.3742.3742  0.375
2010 Manel N, Littman D. RNAi in human monocyte-derived dendritic cells using shRNA vectors Protocol Exchange. DOI: 10.1038/Protex.2010.208  0.323
2010 Qiu J, Diehl G, Fish K, Gong X, Littman D, Zhou L. PS1-19 The aryl hydrocarbon receptor modulates the Th17 and Treg balance and gut immunity Cytokine. 52: 21. DOI: 10.1016/J.Cyto.2010.07.091  0.313
2009 Klunker S, Chong MM, Mantel PY, Palomares O, Bassin C, Ziegler M, Rückert B, Meiler F, Akdis M, Littman DR, Akdis CA. Transcription factors RUNX1 and RUNX3 in the induction and suppressive function of Foxp3+ inducible regulatory T cells. The Journal of Experimental Medicine. 206: 2701-15. PMID 19917773 DOI: 10.1084/Jem.20090596  0.468
2009 Ivanov II, Atarashi K, Manel N, Brodie EL, Shima T, Karaoz U, Wei D, Goldfarb KC, Santee CA, Lynch SV, Tanoue T, Imaoka A, Itoh K, Takeda K, Umesaki Y, ... ... Littman DR, et al. Induction of intestinal Th17 cells by segmented filamentous bacteria. Cell. 139: 485-98. PMID 19836068 DOI: 10.1016/J.Cell.2009.09.033  0.427
2009 Feuerer M, Shen Y, Littman DR, Benoist C, Mathis D. How punctual ablation of regulatory T cells unleashes an autoimmune lesion within the pancreatic islets. Immunity. 31: 654-64. PMID 19818653 DOI: 10.1016/J.Immuni.2009.08.023  0.456
2009 Rudra D, Egawa T, Chong MM, Treuting P, Littman DR, Rudensky AY. Runx-CBFbeta complexes control expression of the transcription factor Foxp3 in regulatory T cells. Nature Immunology. 10: 1170-7. PMID 19767756 DOI: 10.1038/Ni.1795  0.434
2009 Kim JK, Klinger M, Benjamin J, Xiao Y, Erle DJ, Littman DR, Killeen N. Impact of the TCR signal on regulatory T cell homeostasis, function, and trafficking. Plos One. 4: e6580. PMID 19668367 DOI: 10.1371/Journal.Pone.0006580  0.473
2009 Zhou L, Chong MM, Littman DR. Plasticity of CD4+ T cell lineage differentiation. Immunity. 30: 646-55. PMID 19464987 DOI: 10.1016/J.Immuni.2009.05.001  0.492
2009 Zhou L, Littman DR. Transcriptional regulatory networks in Th17 cell differentiation. Current Opinion in Immunology. 21: 146-52. PMID 19328669 DOI: 10.1016/J.Coi.2009.03.001  0.463
2009 Voo KS, Wang YH, Santori FR, Boggiano C, Wang YH, Arima K, Bover L, Hanabuchi S, Khalili J, Marinova E, Zheng B, Littman DR, Liu YJ. Identification of IL-17-producing FOXP3+ regulatory T cells in humans. Proceedings of the National Academy of Sciences of the United States of America. 106: 4793-8. PMID 19273860 DOI: 10.1073/Pnas.0900408106  0.421
2009 Browne EP, Littman DR. Myd88 is required for an antibody response to retroviral infection. Plos Pathogens. 5: e1000298. PMID 19214214 DOI: 10.1371/Journal.Ppat.1000298  0.354
2009 Collins A, Littman DR, Taniuchi I. RUNX proteins in transcription factor networks that regulate T-cell lineage choice. Nature Reviews. Immunology. 9: 106-15. PMID 19165227 DOI: 10.1038/Nri2489  0.406
2009 Michel N, Goffinet C, Ganter K, Allespach I, Kewalramani VN, Saifuddin M, Littman DR, Greene WC, Goldsmith MA, Keppler OT. Human cyclin T1 expression ameliorates a T-cell-specific transcriptional limitation for HIV in transgenic rats, but is not sufficient for a spreading infection of prototypic R5 HIV-1 strains ex vivo. Retrovirology. 6: 2. PMID 19144136 DOI: 10.1186/1742-4690-6-2  0.415
2009 Takatori H, Kanno Y, Watford WT, Tato CM, Weiss G, Ivanov II, Littman DR, O'Shea JJ. Lymphoid tissue inducer-like cells are an innate source of IL-17 and IL-22. The Journal of Experimental Medicine. 206: 35-41. PMID 19114665 DOI: 10.1084/Jem.20072713  0.376
2009 Luci C, Reynders A, Ivanov II, Cognet C, Chiche L, Chasson L, Hardwigsen J, Anguiano E, Banchereau J, Chaussabel D, Dalod M, Littman DR, Vivier E, Tomasello E. Influence of the transcription factor RORgammat on the development of NKp46+ cell populations in gut and skin. Nature Immunology. 10: 75-82. PMID 19029904 DOI: 10.1038/Ni.1681  0.443
2009 Leppkes M, Becker C, Ivanov II, Hirth S, Wirtz S, Neufert C, Pouly S, Murphy AJ, Valenzuela DM, Yancopoulos GD, Becher B, Littman DR, Neurath MF. RORgamma-expressing Th17 cells induce murine chronic intestinal inflammation via redundant effects of IL-17A and IL-17F. Gastroenterology. 136: 257-67. PMID 18992745 DOI: 10.1053/J.Gastro.2008.10.018  0.359
2009 Ivanov I, Zhou L, Huh J, Santori F, Manel N, Chong M, Umesaki Y, Brodie E, Honda K, Littman D. Role of microbiota and transcription factors in control of Th17 cell differentiation Cytokine. 48: 18. DOI: 10.1016/J.Cyto.2009.07.071  0.327
2008 Kao H, Lin J, Littman DR, Shaw AS, Allen PM. Regulated movement of CD4 in and out of the immunological synapse. Journal of Immunology (Baltimore, Md. : 1950). 181: 8248-57. PMID 19050241 DOI: 10.4049/Jimmunol.181.12.8248  0.424
2008 Ivanov II, Frutos Rde L, Manel N, Yoshinaga K, Rifkin DB, Sartor RB, Finlay BB, Littman DR. Specific microbiota direct the differentiation of IL-17-producing T-helper cells in the mucosa of the small intestine. Cell Host & Microbe. 4: 337-49. PMID 18854238 DOI: 10.1016/J.Chom.2008.09.009  0.433
2008 Tassi I, Cella M, Presti R, Colucci A, Gilfillan S, Littman DR, Colonna M. NK cell-activating receptors require PKC-theta for sustained signaling, transcriptional activation, and IFN-gamma secretion. Blood. 112: 4109-16. PMID 18784374 DOI: 10.1182/Blood-2008-02-139527  0.361
2008 Egawa T, Littman DR. ThPOK acts late in specification of the helper T cell lineage and suppresses Runx-mediated commitment to the cytotoxic T cell lineage. Nature Immunology. 9: 1131-9. PMID 18776905 DOI: 10.1038/Ni.1652  0.458
2008 Chong MM, Rasmussen JP, Rudensky AY, Rundensky AY, Littman DR. The RNAseIII enzyme Drosha is critical in T cells for preventing lethal inflammatory disease. The Journal of Experimental Medicine. 205: 2005-17. PMID 18725527 DOI: 10.1084/Jem.20081219  0.38
2008 Quezada SA, Peggs KS, Simpson TR, Shen Y, Littman DR, Allison JP. Limited tumor infiltration by activated T effector cells restricts the therapeutic activity of regulatory T cell depletion against established melanoma. The Journal of Experimental Medicine. 205: 2125-38. PMID 18725522 DOI: 10.1084/Jem.20080099  0.438
2008 Tsuji M, Suzuki K, Kitamura H, Maruya M, Kinoshita K, Ivanov II, Itoh K, Littman DR, Fagarasan S. Requirement for lymphoid tissue-inducer cells in isolated follicle formation and T cell-independent immunoglobulin A generation in the gut. Immunity. 29: 261-71. PMID 18656387 DOI: 10.1016/J.Immuni.2008.05.014  0.455
2008 Manel N, Unutmaz D, Littman DR. The differentiation of human T(H)-17 cells requires transforming growth factor-beta and induction of the nuclear receptor RORgammat. Nature Immunology. 9: 641-9. PMID 18454151 DOI: 10.1038/Ni.1610  0.397
2008 Zhang JX, Diehl GE, Littman DR. Relief of preintegration inhibition and characterization of additional blocks for HIV replication in primary mouse T cells. Plos One. 3: e2035. PMID 18446227 DOI: 10.1371/Journal.Pone.0002035  0.435
2008 Scandella E, Bolinger B, Lattmann E, Miller S, Favre S, Littman DR, Finke D, Luther SA, Junt T, Ludewig B. Restoration of lymphoid organ integrity through the interaction of lymphoid tissue-inducer cells with stroma of the T cell zone. Nature Immunology. 9: 667-75. PMID 18425132 DOI: 10.1038/Ni.1605  0.383
2008 Valdez Y, Diehl GE, Vallance BA, Grassl GA, Guttman JA, Brown NF, Rosenberger CM, Littman DR, Gros P, Finlay BB. Nramp1 expression by dendritic cells modulates inflammatory responses during Salmonella Typhimurium infection. Cellular Microbiology. 10: 1646-61. PMID 18397382 DOI: 10.1111/J.1462-5822.2008.01155.X  0.374
2008 Zhou L, Lopes JE, Chong MM, Ivanov II, Min R, Victora GD, Shen Y, Du J, Rubtsov YP, Rudensky AY, Ziegler SF, Littman DR. TGF-beta-induced Foxp3 inhibits T(H)17 cell differentiation by antagonizing RORgammat function. Nature. 453: 236-40. PMID 18368049 DOI: 10.1038/Nature06878  0.422
2008 Egawa T, Kreslavsky T, Littman DR, von Boehmer H. Lineage diversion of T cell receptor transgenic thymocytes revealed by lineage fate mapping. Plos One. 3: e1512. PMID 18231598 DOI: 10.1371/Journal.Pone.0001512  0.415
2008 Gross O, Grupp C, Steinberg C, Zimmermann S, Strasser D, Hannesschläger N, Reindl W, Jonsson H, Huo H, Littman DR, Peschel C, Yokoyama WM, Krug A, Ruland J. Multiple ITAM-coupled NK-cell receptors engage the Bcl10/Malt1 complex via Carma1 for NF-kappaB and MAPK activation to selectively control cytokine production. Blood. 112: 2421-8. PMID 18192506 DOI: 10.1182/Blood-2007-11-123513  0.386
2008 Leppkes M, Becker C, Wirtz SJ, Ivanov II, Neufert C, Murphy AJ, Valenzuela D, Yancopoulos G, Nesbitt E, Galle PR, Littman DR, Neurath MF. S1701 A Crucial Role of Rorgamma Expressing TH17 Cells in Chronic Intestinal Inflammation Gastroenterology. 134: A-253. DOI: 10.1016/S0016-5085(08)61172-5  0.337
2008 Kappel L, Goldberg G, Ivanov I, Na I, King C, Suh D, Smith O, Ligh C, Littman D, van den Brink M. 27: IL-17 is Required for CD4-Mediated GVHD Biology of Blood and Marrow Transplantation. 14: 12-13. DOI: 10.1016/J.Bbmt.2007.12.035  0.343
2007 Ivanov II, Zhou L, Littman DR. Transcriptional regulation of Th17 cell differentiation. Seminars in Immunology. 19: 409-17. PMID 18053739 DOI: 10.1016/J.Smim.2007.10.011  0.352
2007 Motoda L, Osato M, Yamashita N, Jacob B, Chen LQ, Yanagida M, Ida H, Wee HJ, Sun AX, Taniuchi I, Littman D, Ito Y. Runx1 protects hematopoietic stem/progenitor cells from oncogenic insult. Stem Cells (Dayton, Ohio). 25: 2976-86. PMID 17823240 DOI: 10.1634/Stemcells.2007-0061  0.327
2007 Egawa T, Tillman RE, Naoe Y, Taniuchi I, Littman DR. The role of the Runx transcription factors in thymocyte differentiation and in homeostasis of naive T cells. The Journal of Experimental Medicine. 204: 1945-57. PMID 17646406 DOI: 10.1084/Jem.20070133071408C  0.448
2007 Naoe Y, Setoguchi R, Akiyama K, Muroi S, Kuroda M, Hatam F, Littman DR, Taniuchi I. Repression of interleukin-4 in T helper type 1 cells by Runx/Cbf beta binding to the Il4 silencer. The Journal of Experimental Medicine. 204: 1749-55. PMID 17646405 DOI: 10.1084/Jem.20062456  0.409
2007 Zhou L, Ivanov II, Spolski R, Min R, Shenderov K, Egawa T, Levy DE, Leonard WJ, Littman DR. IL-6 programs T(H)-17 cell differentiation by promoting sequential engagement of the IL-21 and IL-23 pathways. Nature Immunology. 8: 967-74. PMID 17581537 DOI: 10.1038/Ni1488  0.318
2007 Sims TN, Soos TJ, Xenias HS, Dubin-Thaler B, Hofman JM, Waite JC, Cameron TO, Thomas VK, Varma R, Wiggins CH, Sheetz MP, Littman DR, Dustin ML. Opposing effects of PKCtheta and WASp on symmetry breaking and relocation of the immunological synapse. Cell. 129: 773-85. PMID 17512410 DOI: 10.1016/J.Cell.2007.03.037  0.409
2007 Misra RS, Russell JQ, Koenig A, Hinshaw-Makepeace JA, Wen R, Wang D, Huo H, Littman DR, Ferch U, Ruland J, Thome M, Budd RC. Caspase-8 and c-FLIPL associate in lipid rafts with NF-kappaB adaptors during T cell activation. The Journal of Biological Chemistry. 282: 19365-74. PMID 17462996 DOI: 10.1074/Jbc.M610610200  0.356
2007 Littman DR, Singh H. Immunology. Asymmetry and immune memory. Science (New York, N.Y.). 315: 1673-4. PMID 17379796 DOI: 10.1126/Science.1141184  0.372
2007 Boggiano C, Littman DR. HIV's vagina travelogue. Immunity. 26: 145-7. PMID 17307703 DOI: 10.1016/J.Immuni.2007.02.001  0.32
2007 Boggiano C, Manel N, Littman DR. Dendritic cell-mediated trans-enhancement of human immunodeficiency virus type 1 infectivity is independent of DC-SIGN. Journal of Virology. 81: 2519-23. PMID 17182696 DOI: 10.1128/Jvi.01661-06  0.35
2006 Ivanov II, McKenzie BS, Zhou L, Tadokoro CE, Lepelley A, Lafaille JJ, Cua DJ, Littman DR. The orphan nuclear receptor RORgammat directs the differentiation program of proinflammatory IL-17+ T helper cells. Cell. 126: 1121-33. PMID 16990136 DOI: 10.1016/J.Cell.2006.07.035  0.438
2006 Burns JM, Summers BC, Wang Y, Melikian A, Berahovich R, Miao Z, Penfold ME, Sunshine MJ, Littman DR, Kuo CJ, Wei K, McMaster BE, Wright K, Howard MC, Schall TJ. A novel chemokine receptor for SDF-1 and I-TAC involved in cell survival, cell adhesion, and tumor development. The Journal of Experimental Medicine. 203: 2201-13. PMID 16940167 DOI: 10.1084/Jem.20052144  0.395
2006 Ivanov II, Diehl GE, Littman DR. Lymphoid tissue inducer cells in intestinal immunity. Current Topics in Microbiology and Immunology. 308: 59-82. PMID 16922086 DOI: 10.1007/3-540-30657-9_3  0.399
2006 Cardona AE, Pioro EP, Sasse ME, Kostenko V, Cardona SM, Dijkstra IM, Huang D, Kidd G, Dombrowski S, Dutta R, Lee JC, Cook DN, Jung S, Lira SA, Littman DR, et al. Control of microglial neurotoxicity by the fractalkine receptor. Nature Neuroscience. 9: 917-24. PMID 16732273 DOI: 10.1038/Nn1715  0.533
2006 Huang D, Shi FD, Jung S, Pien GC, Wang J, Salazar-Mather TP, He TT, Weaver JT, Ljunggren HG, Biron CA, Littman DR, Ransohoff RM. The neuronal chemokine CX3CL1/fractalkine selectively recruits NK cells that modify experimental autoimmune encephalomyelitis within the central nervous system. Faseb Journal : Official Publication of the Federation of American Societies For Experimental Biology. 20: 896-905. PMID 16675847 DOI: 10.1096/Fj.05-5465Com  0.568
2006 Sun J, Soos T, Kewalramani VN, Osiecki K, Zheng JH, Falkin L, Santambrogio L, Littman DR, Goldstein H. CD4-specific transgenic expression of human cyclin T1 markedly increases human immunodeficiency virus type 1 (HIV-1) production by CD4+ T lymphocytes and myeloid cells in mice transgenic for a provirus encoding a monocyte-tropic HIV-1 isolate. Journal of Virology. 80: 1850-62. PMID 16439541 DOI: 10.1128/Jvi.80.4.1850-1862.2006  0.418
2006 Fogg DK, Sibon C, Miled C, Jung S, Aucouturier P, Littman DR, Cumano A, Geissmann F. A clonogenic bone marrow progenitor specific for macrophages and dendritic cells. Science (New York, N.Y.). 311: 83-7. PMID 16322423 DOI: 10.1126/Science.1117729  0.518
2005 Zaft T, Sapoznikov A, Krauthgamer R, Littman DR, Jung S. CD11chigh dendritic cell ablation impairs lymphopenia-driven proliferation of naive and memory CD8+ T cells. Journal of Immunology (Baltimore, Md. : 1950). 175: 6428-35. PMID 16272295 DOI: 10.4049/Jimmunol.175.10.6428  0.787
2005 Vilz TO, Moepps B, Engele J, Molly S, Littman DR, Schilling K. The SDF-1/CXCR4 pathway and the development of the cerebellar system. The European Journal of Neuroscience. 22: 1831-9. PMID 16262623 DOI: 10.1111/J.1460-9568.2005.04378.X  0.352
2005 Odemis V, Lamp E, Pezeshki G, Moepps B, Schilling K, Gierschik P, Littman DR, Engele J. Mice deficient in the chemokine receptor CXCR4 exhibit impaired limb innervation and myogenesis. Molecular and Cellular Neurosciences. 30: 494-505. PMID 16198599 DOI: 10.1016/J.Mcn.2005.07.019  0.301
2005 Collins A, Littman DR. Selection and lineage specification in the thymus: Commitment 4-stalled Immunity. 23: 4-5. PMID 16039574 DOI: 10.1016/J.Immuni.2005.07.003  0.362
2005 Grueter B, Petter M, Egawa T, Laule-Kilian K, Aldrian CJ, Wuerch A, Ludwig Y, Fukuyama H, Wardemann H, Waldschuetz R, Möröy T, Taniuchi I, Steimle V, Littman DR, Ehlers M. Runx3 regulates integrin alpha E/CD103 and CD4 expression during development of CD4-/CD8+ T cells. Journal of Immunology (Baltimore, Md. : 1950). 175: 1694-705. PMID 16034110 DOI: 10.4049/Jimmunol.175.3.1694  0.414
2005 Egawa T, Eberl G, Taniuchi I, Benlagha K, Geissmann F, Hennighausen L, Bendelac A, Littman DR. Genetic evidence supporting selection of the Vα14i NKT cell lineage from double-positive thymocyte precursors Immunity. 22: 705-716. PMID 15963785 DOI: 10.1016/J.Immuni.2005.03.011  0.44
2005 Davalos D, Grutzendler J, Yang G, Kim JV, Zuo Y, Jung S, Littman DR, Dustin ML, Gan WB. ATP mediates rapid microglial response to local brain injury in vivo. Nature Neuroscience. 8: 752-8. PMID 15895084 DOI: 10.1038/Nn1472  0.466
2005 Geissmann F, Cameron TO, Sidobre S, Manlongat N, Kronenberg M, Briskin MJ, Dustin ML, Littman DR. Intravascular immune surveillance by CXCR6+ NKT cells patrolling liver sinusoids Plos Biology.. 3: e113. PMID 15799695 DOI: 10.1371/Journal.Pbio.0030113  0.408
2005 Feik N, Bilic I, Tinhofer J, Unger B, Littman DR, Ellmeier W. Functional and molecular analysis of the double-positive stage-specific CD8 enhancer E8III during thymocyte development Journal of Immunology. 174: 1513-1524. PMID 15661911 DOI: 10.4049/Jimmunol.174.3.1513  0.388
2005 Niess JH, Brand S, Gu X, Landsman L, Jung S, McCormick BA, Vyas JM, Boes M, Ploegh HL, Fox JG, Littman DR, Reinecker HC. CX3CR1-mediated dendritic cell access to the intestinal lumen and bacterial clearance Science. 307: 254-258. PMID 15653504 DOI: 10.1126/Science.1102901  0.531
2005 Sato T, Thorlacius H, Johnston B, Staton TL, Xiang W, Littman DR, Butcher EC. Role for CXCR6 in recruitment of activated CD8+ lymphocytes to inflamed liver. Journal of Immunology (Baltimore, Md. : 1950). 174: 277-83. PMID 15611250 DOI: 10.4049/Jimmunol.174.1.277  0.407
2004 Nie Y, Waite J, Brewer F, Sunshine MJ, Littman DR, Zou YR. The role of CXCR4 in maintaining peripheral B cell compartments and humoral immunity Journal of Experimental Medicine. 200: 1145-1156. PMID 15520246 DOI: 10.1084/Jem.20041185  0.39
2004 Baumann JG, Unutmaz D, Miller MD, Breun SK, Grill SM, Mirro J, Littman DR, Rein A, KewalRamani VN. Murine T cells potently restrict human immunodeficiency virus infection. Journal of Virology. 78: 12537-47. PMID 15507641 DOI: 10.1128/Jvi.78.22.12537-12547.2004  0.388
2004 Marsland BJ, Soos TJ, Späth G, Littman DR, Kopf M. Protein kinase C theta is critical for the development of in vivo T helper (Th)2 cell but not Th1 cell responses. The Journal of Experimental Medicine. 200: 181-9. PMID 15263025 DOI: 10.1084/Jem.20032229  0.462
2004 Taniuchi I, Littman DR. Epigenetic gene silencing by Runx proteins Oncogene. 23: 4341-4345. PMID 15156191 DOI: 10.1038/Sj.Onc.1207671  0.314
2004 Taniuchi I, Ellmeier W, Littman DR. The CD4/CD8 lineage choice: New insights into epigenetic regulation during T cell development Advances in Immunology. 83: 55-89. PMID 15135628 DOI: 10.1016/S0065-2776(04)83002-5  0.464
2004 Fonteneau JF, Larsson M, Beignon AS, McKenna K, Dasilva I, Amara A, Liu YJ, Lifson JD, Littman DR, Bhardwaj N. Human Immunodeficiency Virus Type 1 Activates Plasmacytoid Dendritic Cells and Concomitantly Induces the Bystander Maturation of Myeloid Dendritic Cells Journal of Virology. 78: 5223-5232. PMID 15113904 DOI: 10.1128/Jvi.78.10.5223-5232.2004  0.386
2004 Madakamutil LT, Christen U, Lena CJ, Wang-Zhu Y, Attinger A, Sundarrajan M, Ellmeier W, von Herrath MG, Jensen P, Littman DR, Cheroutre H. CD8alphaalpha-mediated survival and differentiation of CD8 memory T cell precursors. Science (New York, N.Y.). 304: 590-3. PMID 15105501 DOI: 10.1126/Science.1092316  0.436
2004 Berg-Brown NN, Gronski MA, Jones RG, Elford AR, Deenick EK, Odermatt B, Littman DR, Ohashi PS. PKCθ Signals Activation versus Tolerance In Vivo Journal of Experimental Medicine. 199: 743-752. PMID 15024044 DOI: 10.1084/Jem.20031022  0.455
2004 Eberl G, Marmon S, Sunshine MJ, Rennert PD, Choi Y, Littman DR. An essential function for the nuclear receptor RORgamma(t) in the generation of fetal lymphoid tissue inducer cells. Nature Immunology. 5: 64-73. PMID 14691482 DOI: 10.1038/Ni1022  0.333
2003 Eberl G, Littman DR. The role of the nuclear hormone receptor RORγt in the development of lymph nodes and Peyer's patches Immunological Reviews. 195: 81-90. PMID 12969312 DOI: 10.1034/J.1600-065X.2003.00074.X  0.408
2003 Molyneaux KA, Zinszner H, Kunwar PS, Schaible K, Stebler J, Sunshine MJ, O'Brien W, Raz E, Littman D, Wylie C, Lehmann R. The chemokine SDF1/CXCL12 and its receptor CXCR4 regulate mouse germ cell migration and survival. Development (Cambridge, England). 130: 4279-86. PMID 12900445 DOI: 10.1242/Dev.00640  0.38
2003 Amara A, Littman DR. After Hrs with HIV Journal of Cell Biology. 162: 371-375. PMID 12900390 DOI: 10.1083/Jcb.200307062  0.317
2003 Geissmann F, Jung S, Littman DR. Blood monocytes consist of two principal subsets with distinct migratory properties Immunity. 19: 71-82. PMID 12871640 DOI: 10.1016/S1074-7613(03)00174-2  0.555
2003 Egawa T, Albrecht B, Favier B, Sunshine MJ, Mirchandani K, O'Brien W, Thome M, Littman DR. Requirement for CARMA1 in antigen receptor-induced NF-kappa B activation and lymphocyte proliferation. Current Biology : Cb. 13: 1252-8. PMID 12867038 DOI: 10.1016/S0960-9822(03)00491-3  0.441
2003 Chalasani SH, Baribaud F, Coughlan CM, Sunshine MJ, Lee VM, Doms RW, Littman DR, Raper JA. The chemokine stromal cell-derived factor-1 promotes the survival of embryonic retinal ganglion cells. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 23: 4601-12. PMID 12805300 DOI: 10.1523/Jneurosci.23-11-04601.2003  0.323
2003 Huo Y, Schober A, Forlow SB, Smith DF, Hyman MC, Jung S, Littman DR, Weber C, Ley K. Circulating activated platelets exacerbate atherosclerosis in mice deficient in apolipoprotein E Nature Medicine. 9: 61-67. PMID 12483207 DOI: 10.1038/Nm810  0.458
2003 Niess JH, Brand S, Gu X, Jung S, Littman DR, Reinecker H. Expression of the fractalkine receptor, CX3CR1, characterizes a subpopulation of intestinal antigen sampling dendritic cells Gastroenterology. 124: A152-A153. DOI: 10.1016/S0016-5085(03)80757-6  0.531
2002 Taniuchi I, Osato M, Egawa T, Sunshine MJ, Bae SC, Komori T, Ito Y, Littman DR. Differential requirements for Runx proteins in CD4 repression and epigenetic silencing during T lymphocyte development Cell. 111: 621-633. PMID 12464175 DOI: 10.1016/S0092-8674(02)01111-X  0.411
2002 Taniuchi I, Sunshine MJ, Festenstein R, Littman DR. Evidence for distinct CD4 silencer functions at different stages of thymocyte differentiation Molecular Cell. 10: 1083-1096. PMID 12453416 DOI: 10.1016/S1097-2765(02)00735-9  0.409
2002 Ohlrogge W, Haag F, Löhler J, Seman M, Littman DR, Killeen N, Koch-Nolte F. Generation and characterization of ecto-ADP-ribosyltransferase ART2.1/ART2.2-deficient mice. Molecular and Cellular Biology. 22: 7535-42. PMID 12370300 DOI: 10.1128/Mcb.22.21.7535-7542.2002  0.44
2002 Jung S, Unutmaz D, Wong P, Sano G, De los Santos K, Sparwasser T, Wu S, Vuthoori S, Ko K, Zavala F, Pamer EG, Littman DR, Lang RA. In vivo depletion of CD11c+ dendritic cells abrogates priming of CD8+ T cells by exogenous cell-associated antigens. Immunity. 17: 211-20. PMID 12196292 DOI: 10.1016/S1074-7613(02)00365-5  0.577
2002 Chi TH, Wan M, Zhao K, Taniuchi I, Chen L, Littman DR, Crabtree GR. Reciprocal regulation of CD4/CD8 expression by SWI/SNF-like BAF complexes. Nature. 418: 195-9. PMID 12110891 DOI: 10.1038/Nature00876  0.39
2002 Okada T, Ngo VN, Ekland EH, Förster R, Lipp M, Littman DR, Cyster JG. Chemokine requirements for B cell entry to lymph nodes and Peyer's patches. The Journal of Experimental Medicine. 196: 65-75. PMID 12093871 DOI: 10.1084/Jem.20020201  0.362
2002 Ellmeier W, Sunshine MJ, Maschek R, Littman DR. Combined deletion of CD8 locus cis-regulatory elements affects initiation but not maintenance of CD8 expression Immunity. 16: 623-634. PMID 12049715 DOI: 10.1016/S1074-7613(02)00309-6  0.409
2002 Winoto A, Littman DR. Nuclear hormone receptors in T lymphocytes. Cell. 109: S57-66. PMID 11983153 DOI: 10.1016/S0092-8674(02)00710-9  0.358
2002 Arendt CW, Albrecht B, Soos TJ, Littman DR. Protein kinase C-theta;: signaling from the center of the T-cell synapse. Current Opinion in Immunology. 14: 323-30. PMID 11973130 DOI: 10.1016/S0952-7915(02)00346-1  0.424
2002 Guo J, Hawwari A, Li H, Sun Z, Mahanta SK, Littman DR, Krangel MS, He YW. Regulation of the TCRα repertoire by the survival window of CD4+CD8+ thymocytes Nature Immunology. 3: 469-476. PMID 11967541 DOI: 10.1038/Ni791  0.366
2002 Keppler OT, Welte FJ, Ngo TA, Chin PS, Patton KS, Tsou CL, Abbey NW, Sharkey ME, Grant RM, You Y, Scarborough JD, Ellmeier W, Littman DR, Stevenson M, Charo IF, et al. Progress toward a human CD4/CCR5 transgenic rat model for de novo infection by human immunodeficiency virus type 1 Journal of Experimental Medicine. 195: 719-736. PMID 11901198 DOI: 10.1084/Jem.20011549  0.352
2002 Kwon DS, Gregorio G, Bitton N, Hendrickson WA, Littman DR. DC-SIGN-mediated internalization of HIV is required for trans-enhancement of T cell infection Immunity. 16: 135-144. PMID 11825572 DOI: 10.1016/S1074-7613(02)00259-5  0.408
2002 Harmsen A, Kusser K, Hartson L, Tighe M, Sunshine MJ, Sedgwick JD, Choi Y, Littman DR, Randall TD. Cutting edge: organogenesis of nasal-associated lymphoid tissue (NALT) occurs independently of lymphotoxin-alpha (LT alpha) and retinoic acid receptor-related orphan receptor-gamma, but the organization of NALT is LT alpha dependent. Journal of Immunology (Baltimore, Md. : 1950). 168: 986-90. PMID 11801629 DOI: 10.4049/Jimmunol.168.3.986  0.332
2001 Arendt CW, Littman DR. HIV: master of the host cell. Genome Biology. 2: REVIEWS1030. PMID 11737949 DOI: 10.1186/Gb-2001-2-11-Reviews1030  0.326
2001 Palframan RT, Jung S, Cheng G, Weninger W, Luo Y, Dorf M, Littman DR, Rollins BJ, Zweerink H, Rot A, Von Andrian UH. Inflammatory chemokine transport and presentation in HEV: A remote control mechanism for monocyte recruitment to lymph nodes in inflamed tissues Journal of Experimental Medicine. 194: 1361-1373. PMID 11696600 DOI: 10.1084/Jem.194.9.1361  0.482
2001 Huo Y, Weber C, Forlow SB, Sperandio M, Thatte J, Mack M, Jung S, Littman DR, Ley K. The chemokine KC, but not monocyte chemoattractant protein-1, triggers monocyte arrest on early atherosclerotic endothelium Journal of Clinical Investigation. 108: 1307-1314. PMID 11696575 DOI: 10.1172/Jci12877  0.512
2001 Zou YR, Sunshine MJ, Taniuchi I, Hatam F, Killeen N, Littman DR. Epigenetic silencing of CD4 in T cells committed to the cytotoxic lineage Nature Genetics. 29: 332-336. PMID 11687799 DOI: 10.1038/Ng750  0.398
2001 Baribaud F, Pöhlmann S, Sparwasser T, Kimata MT, Choi YK, Haggarty BS, Ahmad N, Macfarlan T, Edwards TG, Leslie GJ, Arnason J, Reinhart TA, Kimata JT, Littman DR, Hoxie JA, et al. Functional and antigenic characterization of human, rhesus macaque, pigtailed macaque, and murine DC-SIGN. Journal of Virology. 75: 10281-9. PMID 11581396 DOI: 10.1128/Jvi.75.21.10281-10289.2001  0.334
2001 Hargreaves DC, Hyman PL, Lu TT, Ngo VN, Bidgol A, Suzuki G, Zou YR, Littman DR, Cyster JG. A coordinated change in chemokine responsiveness guides plasma cell movements. The Journal of Experimental Medicine. 194: 45-56. PMID 11435471 DOI: 10.1084/Jem.194.1.45  0.339
2001 Wolfer A, Bakker T, Wilson A, Nicolas M, Ioannidis V, Littman DR, Wilson CB, Held W, MacDonald HR, Radtke F. Inactivation of Notch1 in immature thymocytes does not perturb CD4 or CD8 T cell development Nature Immunology. 2: 235-241. PMID 11224523 DOI: 10.1038/85294  0.401
2001 Browning CM, Smith MJ, Clark NM, Lane BR, Parada C, Montano M, KewalRamani VN, Littman DR, Essex M, Roeder RG, Markovitz DM. Human GLI-2 is a tat activation response element-independent Tat cofactor. Journal of Virology. 75: 2314-23. PMID 11160734 DOI: 10.1128/Jvi.75.5.2314-2323.2001  0.324
2000 Ellmeier W, Jung S, Sunshine MJ, Hatam F, Xu Y, Baltimore D, Mano H, Littman DR. Severe B cell deficiency in mice lacking the tec kinase family members Tec and Btk. The Journal of Experimental Medicine. 192: 1611-24. PMID 11104803 DOI: 10.1084/Jem.192.11.1611  0.556
2000 Unutmaz D, Xiang W, Sunshine MJ, Campbell J, Butcher E, Littman DR. The primate lentiviral receptor Bonzo/STRL33 is coordinately regulated with CCR5 and its expression pattern is conserved between human and mouse Journal of Immunology. 165: 3284-3292. PMID 10975845 DOI: 10.4049/Jimmunol.165.6.3284  0.42
2000 Sun Z, Unutmaz D, Zou YR, Sunshine MJ, Pierani A, Brenner-Morton S, Mebius RE, Littman DR. Requirement for RORgamma in thymocyte survival and lymphoid organ development. Science (New York, N.Y.). 288: 2369-73. PMID 10875923 DOI: 10.1126/Science.288.5475.2369  0.432
2000 Jung S, Aliberti J, Graemmel P, Sunshine MJ, Kreutzberg GW, Sher A, Littman DR. Analysis of fractalkine receptor CX(3)CR1 function by targeted deletion and green fluorescent protein reporter gene insertion. Molecular and Cellular Biology. 20: 4106-14. PMID 10805752 DOI: 10.1128/Mcb.20.11.4106-4114.2000  0.495
2000 Gu C, Ma YC, Benjamin J, Littman D, Chao MV, Huang XY. Apoptotic signaling through the beta -adrenergic receptor. A new Gs effector pathway. The Journal of Biological Chemistry. 275: 20726-33. PMID 10767282 DOI: 10.1074/Jbc.M000152200  0.508
2000 Sun Z, Arendt CW, Ellmeier W, Schaeffer EM, Sunshine MJ, Gandhi L, Annes J, Petrzilka D, Kupfer A, Schwartzberg PL, Littman DR. PKC-theta is required for TCR-induced NF-kappaB activation in mature but not immature T lymphocytes. Nature. 404: 402-7. PMID 10746729 DOI: 10.1038/35006090  0.43
2000 Geijtenbeek TBH, Kwon DS, Torensma R, Van Vliet SJ, Van Duijnhoven GCF, Middel J, Cornelissen ILMHA, Nottet HSLM, KewalRamani VN, Littman DR, Figdor CG, Van Kooyk Y. DC-SIGN, a dendritic cell-specific HIV-1-binding protein that enhances trans-infection of T cells Cell. 100: 587-597. PMID 10721995 DOI: 10.1016/S0092-8674(00)80694-7  0.42
1999 Fowell DJ, Shinkai K, Liao XC, Beebe AM, Coffman RL, Littman DR, Locksley RM. Impaired NFATc translocation and failure of Th2 development in Itk- deficient CD4+ T cells Immunity. 11: 399-409. PMID 10549622 DOI: 10.1016/S1074-7613(00)80115-6  0.448
1999 Vidal K, Daniel C, Hill M, Littman DR, Allen PM. Differential requirements for CD4 in TCR-ligand interactions Journal of Immunology. 163: 4811-4818. PMID 10528181  0.328
1999 Unutmaz D, KewalRamani VN, Marmon S, Littman DR. Cytokine signals are sufficient for HIV-1 infection of resting human T lymphocytes Journal of Experimental Medicine. 189: 1735-1746. PMID 10359577 DOI: 10.1084/Jem.189.11.1735  0.444
1999 Ellmeier W, Sawada S, Littman DR. The regulation of CD4 and CD8 coreceptor gene expression during T cell development Annual Review of Immunology. 17: 523-554. PMID 10358767 DOI: 10.1146/Annurev.Immunol.17.1.523  0.449
1999 Schaeffer EM, Debnath J, Yap G, McVicar D, Liao XC, Littman DR, Sher A, Varmus HE, Lenardo MJ, Schwartzberg PL. Requirement for Tec kinases Rlk and Itk in T cell receptor signaling and immunity. Science (New York, N.Y.). 284: 638-41. PMID 10213685 DOI: 10.1126/Science.284.5414.638  0.357
1999 Mörner A, Björndal A, Albert J, Kewalramani VN, Littman DR, Inoue R, Thorstensson R, Fenyö EM, Björling E. Primary human immunodeficiency virus type 2 (HIV-2) isolates, like HIV- 1 isolates, frequently use CCR5 but show promiscuity in coreceptor usage Journal of Virology. 73: 2343-2349. PMID 9971817 DOI: 10.1128/Jvi.73.3.2343-2349.1999  0.33
1999 Kimata JT, Gosink JJ, Kewalramani VN, Rudensey LM, Littman DR, Overbaugh J. Coreceptor specificity of temporal variants of simian immunodeficiency virus Mne Journal of Virology. 73: 1655-1660. PMID 9882375 DOI: 10.1128/Jvi.73.2.1655-1660.1999  0.318
1998 Garber ME, Wei P, KewalRamani VN, Mayall TP, Herrmann CH, Rice AP, Littman DR, Jones KA. The interaction between HIV-1 Tat and human cyclin T1 requires zinc and a critical cysteine residue that is not conserved in the murine CycT1 protein. Genes & Development. 12: 3512-27. PMID 9832504 DOI: 10.1101/Gad.12.22.3512  0.327
1998 Ellmeier W, Sunshine MJ, Losos K, Littman DR. Multiple developmental stage-specific enhancers regulate CD8 expression in developing thymocytes and in thymus-independent T cells Immunity. 9: 485-496. PMID 9806635 DOI: 10.1016/S1074-7613(00)80632-9  0.452
1998 Rivière I, Sunshine MJ, Littman DR. Regulation of IL-4 expression by activation of individual alleles. Immunity. 9: 217-28. PMID 9729042 DOI: 10.1016/S1074-7613(00)80604-4  0.41
1998 Hill CM, Kwon D, Jones M, Davis CB, Marmon S, Daugherty BL, DeMartino JA, Springer MS, Unutmaz D, Littman DR. The amino terminus of human CCR5 is required for its function as a receptor for diverse human and simian immunodeficiency virus envelope glycoproteins. Virology. 248: 357-71. PMID 9721244 DOI: 10.1006/Viro.1998.9283  0.401
1998 Langlois AJ, Desrosiers RC, Lewis MG, Kewalramani VN, Littman DR, Zhou JY, Manson K, Wyand MS, Bolognesi DP, Montefiori DC. Neutralizing antibodies in sera from macaques immunized with attenuated simian immunodeficiency virus Journal of Virology. 72: 6950-6955. PMID 9658152 DOI: 10.1128/Jvi.72.8.6950-6955.1998  0.307
1998 Unutmaz D, KewalRamani VN, Littman DR. G protein-coupled receptors in HIV and SIV entry: New perspectives on lentivirus-host interactions and on the utility of animal models Seminars in Immunology. 10: 225-236. PMID 9653049 DOI: 10.1006/Smim.1998.0134  0.317
1998 Zou YR, Kottman AH, Kuroda M, Taniuchi I, Littman DR. Function of the chemokine receptor CXCR4 in heaematopolesis and in cerebellar development Nature. 393: 595-599. PMID 9634238 DOI: 10.1038/31269  0.388
1998 Littman DR. Chemokine receptors: Keys to AIDS pathogenesis? Cell. 93: 677-680. PMID 9630212 DOI: 10.1016/S0092-8674(00)81429-4  0.316
1998 Michael NL, Nelson JA, KewalRamani VN, Chang G, O'Brien SJ, Mascola JR, Volsky B, Louder M, White GC, Littman DR, Swanstrom R, O'Brien TR. Exclusive and persistent use of the entry coreceptor CXCR4 by human immunodeficiency virus type 1 from a subject homozygous for CCR5 delta32. Journal of Virology. 72: 6040-7. PMID 9621067 DOI: 10.1128/Jvi.72.7.6040-6047.1998  0.396
1998 Tscherning C, Alaeus A, Fredriksson R, Björndal A, Deng H, Littman DR, Fenyö EM, Albert J. Differences in chemokine coreceptor usage between genetic subtypes of HIV-1 Virology. 241: 181-188. PMID 9499793 DOI: 10.1006/Viro.1997.8980  0.385
1998 Trkola A, Ketas T, Kewalramani VN, Endorf F, Binley JM, Katinger H, Robinson J, Littman DR, Moore JP. Neutralization sensitivity of human immunodeficiency virus type 1 primary isolates to antibodies and CD4-based reagents is independent of coreceptor usage Journal of Virology. 72: 1876-1885. PMID 9499039 DOI: 10.1128/Jvi.72.3.1876-1885.1998  0.379
1998 Liao XC, Littman DR, Weiss A. Itk and Fyn make independent contributions to T cell activation. The Journal of Experimental Medicine. 186: 2069-73. PMID 9396778 DOI: 10.1084/Jem.186.12.2069  0.407
1997 Davis CB, Dikic I, Unutmaz D, Hill CM, Arthos J, Siani MA, Thompson DA, Schlessinger J, Littman DR. Signal transduction due to HIV-1 envelope interactions with chemokine receptors CXCR4 or CCR5. The Journal of Experimental Medicine. 186: 1793-8. PMID 9362541 DOI: 10.1084/Jem.186.10.1793  0.355
1997 Scarlatti G, Tresoldi E, Björndal A, Fredriksson R, Colognesi C, Deng HK, Malnati MS, Plebani A, Siccardi AG, Littman DR, Fenyö EM, Lusso P. In vivo evolution of HIV-1 co-receptor usage and sensitivity to chemokine-mediated suppression. Nature Medicine. 3: 1259-65. PMID 9359702 DOI: 10.1038/Nm1197-1259  0.329
1997 Ellmeier W, Sunshine MJ, Losos K, Hatam F, Littman DR. An enhancer that directs lineage-specific expression of CD8 in positively selected thymocytes and mature T cells. Immunity. 7: 537-47. PMID 9354474 DOI: 10.1016/S1074-7613(00)80375-1  0.414
1997 Hill CM, Deng H, Unutmaz D, Kewalramani VN, Bastiani L, Gorny MK, Zolla-Pazner S, Littman DR. Envelope glycoproteins from human immunodeficiency virus types 1 and 2 and simian immunodeficiency virus can use human CCR5 as a coreceptor for viral entry and make direct CD4-dependent interactions with this chemokine receptor Journal of Virology. 71: 6296-6304. PMID 9261346 DOI: 10.1128/Jvi.71.9.6296-6304.1997  0.37
1997 Deng H, Unutmaz D, Kewalramani VN, Littman DR. Expression cloning of new receptors used by simian and human immunodeficiency viruses Nature. 388: 296-300. PMID 9230441 DOI: 10.1038/40894  0.365
1997 Liao XC, Fournier S, Killeen N, Weiss A, Allison JP, Littman DR. Itk negatively regulates induction of T cell proliferation by CD28 costimulation Journal of Experimental Medicine. 186: 221-228. PMID 9221751 DOI: 10.1084/Jem.186.2.221  0.459
1997 Unutmaz D, Littman DR. Expression pattern of HIV-1 coreceptors on T cells: Implications for viral transmission and lymphocyte homing Proceedings of the National Academy of Sciences of the United States of America. 94: 1615-1618. PMID 9050826 DOI: 10.1073/Pnas.94.5.1615  0.363
1997 Teh S, Killeen N, Tarakhovsky A, Littman DR, Teh H. CD2 Regulates the Positive Selection and Function of Antigen-Specific CD4−CD8+ T Cells Blood. 89: 1308-1318. DOI: 10.1182/Blood.V89.4.1308  0.455
1997 Ranga U, Woffendin C, Yang ZY, Xu L, Verma S, Littman DR, Nabel GJ. Cell and viral regulatory elements enhance the expression and function of a human immunodeficiency virus inhibitory gene. Journal of Virology. 71: 7020-7029. DOI: 10.1128/Jvi.71.9.7020-7029.1997  0.42
1997 Björndal A, Deng H, Jansson M, Fiore JR, Colognesi C, Karlsson A, Albert J, Scarlatti G, Littman DR, Fenyö EM. Coreceptor usage of primary human immunodeficiency virus type 1 isolates varies according to biological phenotype. Journal of Virology. 71: 7478-7487. DOI: 10.1128/Jvi.71.10.7478-7487.1997  0.388
1997 Bachmann MF, Littman DR, Liao XC. Antiviral immune responses in Itk-deficient mice. Journal of Virology. 71: 7253-7257. DOI: 10.1128/Jvi.71.10.7253-7257.1997  0.394
1997 Irie H, Crooks M, Littman D, Burakoff S. The role of CD8β in T cell development may be due to its regulation of CD8α-associated Lck kinase activity Immunology Letters. 56: 57. DOI: 10.1016/S0165-2478(97)85216-9  0.378
1996 Weiss CD, Barnett SW, Cacalano N, Killeen N, Littman DR, White JM. Studies of HIV-1 envelope glycoprotein-mediated fusion using a simple fluorescence assay Aids. 10: 241-246. PMID 8882662 DOI: 10.1097/00002030-199603000-00001  0.453
1996 Liao XC, Littman DR. Altered T cell receptor signaling and disrupted T cell development in mice lacking Itk. Immunity. 3: 757-69. PMID 8777721 DOI: 10.1016/1074-7613(95)90065-9  0.461
1996 Deng H, Liu R, Ellmeier W, Choe S, Unutmaz D, Burkhart M, Di Marzio P, Marmon S, Sutton RE, Mark Hill C, Davis CB, Peiper SC, Schall TJ, Littman DR, Landau NR. Identification of a major co-receptor for primary isolates of HIV-1 Nature. 381: 661-666. PMID 8649511 DOI: 10.1038/381661A0  0.384
1996 Williams O, Tanaka Y, Bix M, Murdjeva M, Littman DR, Kioussis D. Inhibition of thymocyte negative selection by T cell receptor antagonist peptides. European Journal of Immunology. 26: 532-8. PMID 8605917 DOI: 10.1002/Eji.1830260305  0.353
1996 Killeen N, Littman DR. The regulation and function of the CD4 coreceptor during T lymphocyte development Current Topics in Microbiology and Immunology. 205: 88-106. PMID 8575199 DOI: 10.1007/978-3-642-79798-9_5  0.442
1996 Sutton RE, Littman DR. Broad host range of human T-cell leukemia virus type 1 demonstrated with an improved pseudotyping system. Journal of Virology. 70: 7322-7326. DOI: 10.1128/Jvi.70.10.7322-7326.1996  0.414
1995 Crooks MEC, Littman DR, Carter RH, Fearon DT, Weiss A, Stein PH. CD28-mediated costimulation in the absence of phosphatidylinositol 3-kinase association and activation Molecular and Cellular Biology. 15: 6820-6828. PMID 8524248 DOI: 10.1128/Mcb.15.12.6820  0.418
1995 Crooks ME, Littman DR. Disruption of T lymphocyte positive and negative selection in mice lacking the CD8 beta chain. Immunity. 1: 277-85. PMID 7889415 DOI: 10.1016/1074-7613(94)90079-5  0.417
1995 Golding H, Dimitrov DS, Manischewitz J, Broder CC, Robinson J, Fabian S, Littman DR, Lapham CK. Phorbol ester-induced down modulation of tailless CD4 receptors requires prior binding of gp120 and suggests a role for accessory molecules Journal of Virology. 69: 6140-6148. PMID 7545243 DOI: 10.1128/Jvi.69.10.6140-6148.1995  0.405
1995 Killeen N, Littman DR. The function of the CD4 coreceptor in the development of t cells International Reviews of Immunology. 13: 15-27. PMID 7494106 DOI: 10.3109/08830189509061735  0.453
1995 Xu H, Littman DR. The kinase-dependent function of Lck in T-cell activation requires an intact site for tyrosine autophosphorylation. Annals of the New York Academy of Sciences. 766: 99-116. PMID 7486706 DOI: 10.1111/J.1749-6632.1995.Tb26655.X  0.355
1995 Benkirane M, Schmid-Antomarchi H, Littman DR, Hirn M, Rossi B, Devaux C. The cytoplasmic tail of CD4 is required for inhibition of human immunodeficiency virus type 1 replication by antibodies that bind to the immunoglobulin CDR3-like region in domain 1 of CD4. Journal of Virology. 69: 6904-6910. DOI: 10.1128/Jvi.69.11.6904-6910.1995  0.388
1994 Weiss A, Littman DR. Signal transduction by lymphocyte antigen receptors. Cell. 76: 263-74. PMID 8293463 DOI: 10.1016/0092-8674(94)90334-4  0.359
1994 Sawada S, Scarborough JD, Killeen N, Littman DR. A lineage-specific transcriptional silencer regulates CD4 gene expression during T lymphocyte development Cell. 77: 917-929. PMID 8004678 DOI: 10.1016/0092-8674(94)90140-6  0.386
1994 Littman DR. Immunodeficiency viruses. Not enough sans Nef. Current Biology : Cb. 4: 618-20. PMID 7953537 DOI: 10.1016/S0960-9822(00)00135-4  0.362
1994 Davis CB, Littman DR. Thymocyte lineage commitment: is it instructed to stochastic? Current Opinion in Immunology. 6: 266-272. PMID 7912080 DOI: 10.1016/0952-7915(94)90100-7  0.395
1994 Rajan TV, Nelson FK, Killeen N, Shultz LD, Yates JA, Bailis JM, Littman DR, Greiner DL. CD4+ T-Lymphocytes Are Not Required for Murine Resistance to the Human Filarial Parasite, Brugia malayi Experimental Parasitology. 78: 352-360. PMID 7911434 DOI: 10.1006/Expr.1994.1038  0.433
1994 Bendelac A, Killeen N, Littman DR, Schwartz RH. A subset of CD4+ thymocytes selected by MHC class I molecules Science. 263: 1774-1778. PMID 7907820 DOI: 10.1126/Science.7907820  0.385
1994 Littman DR, Davis CB, Killeen N, Xu H. Signal transduction during T cell development Advances in Experimental Medicine and Biology. 365: 63. PMID 7887314 DOI: 10.1007/978-1-4899-0987-9_7  0.432
1993 Locksley RM, Reiner SL, Hatam F, Littman DR, Killeen N. Helper T cells without CD4: Control of leishmaniasis in CD4-deficient mice Science. 261: 1448-1451. PMID 8367726 DOI: 10.1126/Science.8367726  0.453
1993 Xu H, Littman DR. A kinase-independent function of Lck in potentiating antigen-specific T cell activation. Cell. 74: 633-43. PMID 8358792 DOI: 10.1016/0092-8674(93)90511-N  0.442
1993 Killeen N, Littman DR. Helper T-cell development in the absence of CD4-p56Ick association Nature. 364: 729-732. PMID 8355789 DOI: 10.1038/364729A0  0.437
1993 Sawada S, Littman DR. A heterodimer of HEB and an E12-related protein interacts with the CD4 enhancer and regulates its activity in T-cell lines. Molecular and Cellular Biology. 13: 5620-8. PMID 8355705 DOI: 10.1128/Mcb.13.9.5620  0.394
1993 Davis CB, Killeen N, Crooks MEC, Raulet D, Littman DR. Evidence for a stochastic mechanism in the differentiation of mature subsets of T lymphocytes Cell. 73: 237-247. PMID 8097431 DOI: 10.1016/0092-8674(93)90226-G  0.412
1993 Killeen N, Davis CB, Chu K, Crooks ME, Sawada S, Scarborough JD, Boyd KA, Stuart SG, Xu H, Littman DR. CD4 function in thymocyte differentiation and T cell activation Philosophical Transactions of the Royal Society of London. Series B: Biological Sciences. 342: 25-34. PMID 7904343 DOI: 10.1098/Rstb.1993.0131  0.449
1993 Zingler K, Littman DR. Truncation of the cytoplasmic domain of the simian immunodeficiency virus envelope glycoprotein increases env incorporation into particles and fusogenicity and infectivity. Journal of Virology. 67: 2824-2831. DOI: 10.1128/Jvi.67.5.2824-2831.1993  0.359
1993 Golding H, Blumenthal R, Manischewitz J, Littman DR, Dimitrov DS. Cell fusion mediated by interaction of a hybrid CD4.CD8 molecule with the human immunodeficiency virus type 1 envelope glycoprotein does occur after a long lag time. Journal of Virology. 67: 6469-6475. DOI: 10.1128/Jvi.67.11.6469-6475.1993  0.384
1993 Killeen N, Sawada S, Littman D. Regulated expression of human CD4 rescues helper T cell development in mice lacking expression of endogenous CD4. The Embo Journal. 12: 1547-1553. DOI: 10.1002/J.1460-2075.1993.Tb05798.X  0.457
1992 Page KA, Stearns SM, Littman DR. Analysis of mutations in the V3 domain of gp160 that affect fusion and infectivity Journal of Virology. 66: 524-533. PMID 1727497 DOI: 10.1128/Jvi.66.1.524-533.1992  0.333
1992 Killeen N, Moriarty A, Teh HS, Littman DR. Requirement for CD8-major histocompatibility complex class I interaction in positive and negative selection of developing T cells Journal of Experimental Medicine. 176: 89-97. PMID 1613468 DOI: 10.1084/Jem.176.1.89  0.444
1992 Van Oers NSC, Garvin AM, Davis CB, Forbush KA, Carlow DA, Littman DR, Perlmutter RM, Teh HS. Disruption of CD8-dependent negative and positive selection of thymocytes is correlated with a decreased association between CD8 and the protein tyrosine kinase, p56lck European Journal of Immunology. 22: 735-743. PMID 1547820 DOI: 10.1002/Eji.1830220317  0.408
1992 Van Oers NSC, Garvin AM, Cooke MP, Davis CB, Littman DR, Perlmutter RM, Teh HS. Differential involvement of protein tyrosine kinases p56(lck) and p59(fyn) in T cell development Advances in Experimental Medicine and Biology. 323: 89-100. PMID 1485568 DOI: 10.1007/978-1-4615-3396-2_12  0.439
1992 Killeen N, Stuart S, Littman D. Development and function of T cells in mice with a disrupted CD2 gene. The Embo Journal. 11: 4329-4336. DOI: 10.1002/J.1460-2075.1992.Tb05532.X  0.503
1991 Sawada S, Littman DR. Identification and characterization of a T-cell-specific enhancer adjacent to the murine CD4 gene. Molecular and Cellular Biology. 11: 5506-15. PMID 1922061 DOI: 10.1128/Mcb.11.11.5506  0.399
1991 Landau NR, Page KA, Littman DR. Pseudotyping with human T-cell leukemia virus type I broadens the human immunodeficiency virus host Journal of Virology. 65: 162-169. PMID 1845882 DOI: 10.1128/Jvi.65.1.162-169.1991  0.333
1991 Teitell M, Mescher MF, Olson CA, Littman DR, Kronenberg M. The thymus leukemia antigen binds human and mouse CD8. The Journal of Experimental Medicine. 174: 1131-8. PMID 1834760 DOI: 10.1084/Jem.174.5.1131  0.323
1991 Teh HS, Garvin AM, Forbush KA, Carlow DA, Davis CB, Littman DR, Perlmutter RM. Participation of CD4 coreceptor molecules in T-cell repertoire selection Nature. 349: 241-243. PMID 1824796 DOI: 10.1038/349241A0  0.466
1991 Poulin L, Evans LA, Tang SB, Barboza A, Legg H, Littman DR, Levy JA. Several CD4 domains can play a role in human immunodeficiency virus infection in cells. Journal of Virology. 65: 4893-901. PMID 1714523 DOI: 10.1128/Jvi.65.9.4893-4901.1991  0.411
1991 Glaichenhaus N, Shastri N, Littman DR, Turner JM. Requirement for association of p56lck with CD4 in antigen-specific signal transduction in T cells Cell. 64: 511-520. PMID 1671341 DOI: 10.1016/0092-8674(91)90235-Q  0.447
1990 Littman DR. Role of cell-to-cell interactions in T lymphocyte development and activation. Current Opinion in Cell Biology. 1: 920-8. PMID 2697295 DOI: 10.1016/0955-0674(89)90059-8  0.424
1990 Page KA, Landau NR, Littman DR. Construction and use of a human immunodeficiency virus vector for analysis of virus infectivity Journal of Virology. 64: 5270-5276. PMID 2214018 DOI: 10.1128/Jvi.64.11.5270-5276.1990  0.316
1990 Salter RD, Benjamin RJ, Wesley PK, Buxton SE, Garrett TP, Clayberger C, Krensky AM, Norment AM, Littman DR, Parham P. A binding site for the T-cell co-receptor CD8 on the alpha 3 domain of HLA-A2. Nature. 345: 41-6. PMID 2109837 DOI: 10.1038/345041A0  0.412
1990 Turner JM, Brodsky MH, Irving BA, Levin SD, Perlmutter RM, Littman DR. Interaction of the unique N-terminal region of tyrosine kinase p56lck with cytoplasmic domains of CD4 and CD8 is mediated by cysteine motifs. Cell. 60: 755-65. PMID 2107025 DOI: 10.1016/0092-8674(90)90090-2  0.383
1989 Salter RD, Norment AM, Chen BP, Clayberger C, Krensky AM, Littman DR, Parham P. Polymorphism in the alpha 3 domain of HLA-A molecules affects binding to CD8. Nature. 338: 345-7. PMID 2784196 DOI: 10.1038/338345A0  0.359
1989 Parham P, Benjamin RJ, Chen BP, Clayberger C, Ennis PD, Krensky AM, Lawlor DA, Littman DR, Norment AM, Orr HT. Diversity of class I HLA molecules: functional and evolutionary interactions with T cells. Cold Spring Harbor Symposia On Quantitative Biology. 54: 529-43. PMID 2700944 DOI: 10.1101/Sqb.1989.054.01.063  0.346
1988 Norment AM, Salter RD, Parham P, Engelhard VH, Littman DR. Cell-cell adhesion mediated by CD8 and MHC class I molecules Nature. 336: 79-81. PMID 3263576 DOI: 10.1038/336079A0  0.453
1988 Littman DR, Maddon PJ, Axel R. Corrected CD4 sequence. Cell. 55: 541. PMID 3263213 DOI: 10.1016/0092-8674(88)90211-5  0.557
1988 Kaldjian E, McCarthy SA, Sharrow SO, Littman DR, Klausner RD, Singer A. Nonequivalent effects of PKC activation by PMA on murine CD4 and CD8 cell-surface expression. Faseb Journal : Official Publication of the Federation of American Societies For Experimental Biology. 2: 2801-6. PMID 3261700 DOI: 10.1096/Fasebj.2.12.3261700  0.413
1988 Bedinger P, Moriarty A, von Borstel RC, Donovan NJ, Steimer KS, Littman DR. Internalization of the human immunodeficiency virus does not require the cytoplasmic domain of CD4. Nature. 334: 162-5. PMID 3260353 DOI: 10.1038/334162A0  0.383
1988 Landau NR, Warton M, Littman DR. The envelope glycoprotein of the human immunodeficiency virus binds to the immunoglobulin-like domain of CD4. Nature. 334: 159-62. PMID 3260352 DOI: 10.1038/334159A0  0.372
1988 Lonberg N, Gettner SN, Lacy E, Littman DR. Mouse brain CD4 transcripts encode only the COOH-terminal half of the protein. Molecular and Cellular Biology. 8: 2224-8. PMID 3260331 DOI: 10.1128/Mcb.8.5.2224  0.424
1988 Loh EY, Lanier LL, Turck CW, Littman DR, Davis MM, Chien YH, Weiss A. Identification and sequence of a fourth human T cell antigen receptor chain. Nature. 330: 569-72. PMID 2825032 DOI: 10.1038/330569A0  0.426
1988 Norment AM, Littman DR. A second subunit of CD8 is expressed in human T cells. The Embo Journal. 7: 3433-3439. DOI: 10.1002/J.1460-2075.1988.Tb03217.X  0.391
1987 Littman DR. The structure of the CD4 and CD8 genes. Annual Review of Immunology. 5: 561-84. PMID 3109457 DOI: 10.1146/Annurev.Iy.05.040187.003021  0.436
1987 Littman DR, Newton M, Crommie D, Ang SL, Seidman JG, Gettner SN, Weiss A. Characterization of an expressed CD3-associated Ti gamma-chain reveals C gamma domain polymorphism. Nature. 326: 85-8. PMID 3102973 DOI: 10.1038/326085A0  0.378
1987 Littman DR, Gettner SN. Unusual intron in the immunoglobulin domain of the newly isolated murine CD4 (L3T4) gene. Nature. 325: 453-5. PMID 3027575 DOI: 10.1038/325453A0  0.439
1987 Pelicci PG, Neri A, Knowles DM, Littman DR, Dalla-Favera R, Subar M. Arrangements and rearrangements of the human T-cell receptor gamma gene Annals of the New York Academy of Sciences. 511: 232-245. PMID 2964218 DOI: 10.1111/J.1749-6632.1987.Tb36251.X  0.382
1987 Hashimoto Y, Yui K, Littman D, Greene MI. T-cell receptor genes in autoimmune mice: T-cell subsets have unexpected T-cell receptor gene programs. Proceedings of the National Academy of Sciences of the United States of America. 84: 5883-5887. PMID 2441398 DOI: 10.1073/Pnas.84.16.5883  0.432
1987 Lanier LL, Federspiel NA, Ruitenberg JJ, Phillips JH, Allison JP, Littman D, Weiss A. The T cell antigen receptor complex expressed on normal peripheral blood CD4-, CD8- T lymphocytes. A CD3-associated disulfide-linked gamma chain heterodimer. The Journal of Experimental Medicine. 165: 1076-94. PMID 2435832 DOI: 10.1084/Jem.165.4.1076  0.451
1986 McDougal JS, Maddon PJ, Dalgleish AG, Clapham PR, Littman DR, Godfrey M, Maddon DE, Chess L, Weiss RA, Axel R. The T4 glycoprotein is a cell-surface receptor for the AIDS virus. Cold Spring Harbor Symposia On Quantitative Biology. 51: 703-11. PMID 3495395 DOI: 10.1101/Sqb.1986.051.01.083  0.623
1986 Isobe M, Huebner K, Maddon PJ, Littman DR, Axel R, Croce CM. The gene encoding the T-cell surface protein T4 is located on human chromosome 12. Proceedings of the National Academy of Sciences of the United States of America. 83: 4399-402. PMID 3086883 DOI: 10.1073/Pnas.83.12.4399  0.573
1985 Littman DR, Thomas Y, Maddon PJ, Chess L, Axel R. The isolation and sequence of the gene encoding T8: a molecule defining functional classes of T lymphocytes. Cell. 40: 237-46. PMID 3871356 DOI: 10.1016/0092-8674(85)90138-2  0.615
1985 Maddon PJ, Littman DR, Godfrey M, Maddon DE, Chess L, Axel R. The isolation and nucleotide sequence of a cDNA encoding the T cell surface protein T4: a new member of the immunoglobulin gene family. Cell. 42: 93-104. PMID 2990730 DOI: 10.1016/S0092-8674(85)80105-7  0.59
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