Mark D. Distefano - Publications

Chemistry University of Minnesota, Twin Cities, Minneapolis, MN 
protein engineering, protein prenylation and cellular patterning

151 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2020 Hammers MD, Hodny MH, Bader TK, Mahmoodi MM, Fang S, Fenton AD, Nurie K, Trial HO, Xu F, Healy AT, Ball ZT, Blank DA, Distefano MD. Two-photon uncaging of bioactive thiols in live cells at wavelengths above 800 nm. Organic & Biomolecular Chemistry. PMID 33349821 DOI: 10.1039/d0ob01986k  0.92
2020 Qu W, Suazo KF, Liu W, Cheng S, Jeong A, Hottman D, Yuan LL, Distefano MD, Li L. Neuronal Protein Farnesylation Regulates Hippocampal Synaptic Plasticity and Cognitive Function. Molecular Neurobiology. PMID 33098528 DOI: 10.1007/s12035-020-02169-w  0.76
2020 Kilic O, Matos de Souza MR, Almotlak A, Wang Y, Siegfried J, Distefano MD, Wagner CR. Anti-EGFR Fibronectin Bispecific Chemically Self-Assembling Nanorings (CSANs) Induce Potent T-cell Mediated Anti-Tumor Response and Downregulation of EGFR Signaling and PD-1/PD-L1 Expression. Journal of Medicinal Chemistry. PMID 32852209 DOI: 10.1021/acs.jmedchem.0c00489  0.48
2020 Brandt AC, McNally L, Lorimer EL, Unger B, Koehn OJ, Suazo KF, Rein L, Szabo A, Tsaih SW, Distefano MD, Flister MJ, Rigo F, McNally MT, Williams CL. Splice switching an oncogenic ratio of SmgGDS isoforms as a strategy to diminish malignancy. Proceedings of the National Academy of Sciences of the United States of America. PMID 32019878 DOI: 10.1073/pnas.1914153117  0.76
2019 Bader TK, Xu F, Hodny MH, Blank DA, Distefano MD. A methoxy-substituted nitrodibenzofuran-based protecting group with an improved two-photon action cross-section for thiol protection in solid phase peptide synthesis. The Journal of Organic Chemistry. PMID 31891500 DOI: 10.1021/acs.joc.9b02751  0.64
2019 Zhang Y, Auger S, Schaefer JV, Plückthun A, Distefano MD. Site-Selective Enzymatic Labeling of Designed Ankyrin Repeat Proteins Using Protein Farnesyltransferase. Methods in Molecular Biology (Clifton, N.J.). 2033: 207-219. PMID 31332756 DOI: 10.1007/978-1-4939-9654-4_14  0.92
2019 Hsu ET, Vervacke JS, Distefano MD, Hrycyna CA. A Quantitative FRET Assay for the Upstream Cleavage Activity of the Integral Membrane Proteases Human ZMPSTE24 and Yeast Ste24. Methods in Molecular Biology (Clifton, N.J.). 2009: 279-293. PMID 31152411 DOI: 10.1007/978-1-4939-9532-5_21  0.6
2019 Ahmadi M, Suazo KF, Distefano MD. Optimization of Metabolic Labeling with Alkyne-Containing Isoprenoid Probes. Methods in Molecular Biology (Clifton, N.J.). 2009: 35-43. PMID 31152393 DOI: 10.1007/978-1-4939-9532-5_3  0.76
2018 Zhang Y, Park KY, Suazo KF, Distefano MD. Recent progress in enzymatic protein labelling techniques and their applications. Chemical Society Reviews. PMID 30259933 DOI: 10.1039/c8cs00537k  0.92
2018 Suazo KF, Hurben AK, Liu K, Xu F, Thao P, Sudheer C, Li L, Distefano MD. Metabolic Labeling of Prenylated Proteins Using Alkyne-Modified Isoprenoid Analogues. Current Protocols in Chemical Biology. e46. PMID 30058775 DOI: 10.1002/cpch.46  0.76
2018 Pujari SS, Zhang Y, Ji S, Distefano MD, Tretyakova NY. Site-specific cross-linking of proteins to DNA via a new bioorthogonal approach employing oxime ligation. Chemical Communications (Cambridge, England). PMID 29851420 DOI: 10.1039/c8cc01300d  0.92
2018 Jeong A, Suazo KF, Wood WG, Distefano MD, Li L. Isoprenoids and protein prenylation: implications in the pathogenesis and therapeutic intervention of Alzheimer's disease. Critical Reviews in Biochemistry and Molecular Biology. 53: 279-310. PMID 29718780 DOI: 10.1080/10409238.2018.1458070  0.76
2018 Fisher SA, Tam RY, Fokina A, Mahmoodi MM, Distefano MD, Shoichet MS. Photo-immobilized EGF chemical gradients differentially impact breast cancer cell invasion and drug response in defined 3D hydrogels. Biomaterials. PMID 29452913 DOI: 10.1016/j.biomaterials.2018.01.032  0.92
2017 Blanden MJ, Suazo KF, Hildebrandt ER, Hardgrove DS, Patel M, Saunders WP, Distefano MD, Schmidt WK, Hougland JL. Efficient farnesylation of an extended C-terminal C(x)3X sequence motif expands the scope of the prenylated proteome. The Journal of Biological Chemistry. PMID 29282289 DOI: 10.1074/jbc.M117.805770  0.76
2017 Diaz-Rodriguez V, Hsu ET, Ganusova E, Werst ER, Becker JM, Hrycyna CA, Distefano MD. a-Factor Analogues Containing Alkyne- and Azide-Functionalized Isoprenoids Are Efficiently Enzymatically Processed and Retain Wild-Type Bioactivity. Bioconjugate Chemistry. PMID 29188996 DOI: 10.1021/acs.bioconjchem.7b00648  0.48
2016 Suazo KF, Schaber C, Palsuledesai CC, Odom John AR, Distefano MD. Global proteomic analysis of prenylated proteins in Plasmodium falciparum using an alkyne-modified isoprenoid analogue. Scientific Reports. 6: 38615. PMID 27924931 DOI: 10.1038/srep38615  0.76
2016 Wickramaratne S, Ji S, Mukherjee S, Su Y, Pence MG, Lior-Hoffmann L, Fu I, Broyde S, Guengerich FP, Distefano M, Scharer OD, Sham YY, Tretyakova N. Bypass of DNA-Protein Cross-links Conjugated to the 7-Deazaguanine Position of DNA by Translesion Synthesis Polymerases. The Journal of Biological Chemistry. PMID 27621316 DOI: 10.1074/jbc.M116.745257  0.4
2016 Mahmoodi MM, Fisher SA, Tam RY, Goff PC, Anderson RB, Wissinger JE, Blank DA, Shoichet MS, Distefano MD. 6-Bromo-7-hydroxy-3-methylcoumarin (mBhc) is an efficient multi-photon labile protecting group for thiol caging and three-dimensional chemical patterning. Organic & Biomolecular Chemistry. PMID 27529405 DOI: 10.1039/c6ob01045h  1
2016 Palsuledesai CC, Ochocki JD, Kuhns MM, Wang YC, Warmka JK, Chernick DS, Wattenberg EV, Li L, Arriaga EA, Distefano MD. Metabolic Labeling with an Alkyne-modified Isoprenoid Analog Facilitates Imaging and Quantification of the Prenylome in Cells. Acs Chemical Biology. PMID 27525511 DOI: 10.1021/acschembio.6b00421  1
2016 Mahmoodi MM, Abate-Pella D, Pundsack TJ, Palsuledesai CC, Goff PC, Blank DA, Distefano MD. Nitrodibenzofuran: a One- and Two-Photon Sensitive Protecting Group that is Superior to Brominated Hydroxycoumarin for Thiol Caging in Peptides. Journal of the American Chemical Society. PMID 27027927 DOI: 10.1021/jacs.5b11759  0.92
2015 Jennings BC, Danowitz AM, Wang YC, Gibbs RA, Distefano MD, Fierke CA. Analogs of farnesyl diphosphate alter CaaX substrate specificity and reactions rates of protein farnesyltransferase. Bioorganic & Medicinal Chemistry Letters. PMID 26803203 DOI: 10.1016/j.bmcl.2015.12.079  1
2015 Wang YC, Distefano MD. Synthetic isoprenoid analogues for the study of prenylated proteins: Fluorescent imaging and proteomic applications. Bioorganic Chemistry. 64: 59-65. PMID 26709869 DOI: 10.1016/j.bioorg.2015.12.003  1
2015 Mohammed I, Hampton SE, Ashall L, Hildebrandt ER, Kutlik RA, Manandhar SP, Floyd BJ, Smith HE, Dozier JK, Distefano MD, Schmidt WK, Dore TM. 8-Hydroxyquinoline-based inhibitors of the Rce1 protease disrupt Ras membrane localization in human cells. Bioorganic & Medicinal Chemistry. PMID 26706114 DOI: 10.1016/j.bmc.2015.11.043  1
2015 Zhang Y, Blanden MJ, Chava S, Gangopadhyay SA, Rashidian M, Hougland JL, Distefano MD. Simultaneous Site-Specific Dual Protein Labeling Using Protein Prenyltransferases. Bioconjugate Chemistry. PMID 26561785 DOI: 10.1021/acs.bioconjchem.5b00553  1
2015 Dozier JK, Distefano MD. Site-Specific PEGylation of Therapeutic Proteins. International Journal of Molecular Sciences. 16: 25831-64. PMID 26516849 DOI: 10.3390/ijms161025831  1
2015 Laudenbach M, Baruffaldi F, Vervacke JS, Distefano MD, Titcombe PJ, Mueller DL, Tubo NJ, Griffith TS, Pravetoni M. The Frequency of Naive and Early-Activated Hapten-Specific B Cell Subsets Dictates the Efficacy of a Therapeutic Vaccine against Prescription Opioid Abuse. Journal of Immunology (Baltimore, Md. : 1950). 194: 5926-36. PMID 25972483 DOI: 10.4049/jimmunol.1500385  1
2015 Mahmoodi MM, Rashidian M, Zhang Y, Distefano MD. Application of meta- and para-Phenylenediamine as Enhanced Oxime Ligation Catalysts for Protein Labeling, PEGylation, Immobilization, and Release. Current Protocols in Protein Science / Editorial Board, John E. Coligan ... [Et Al.]. 79: 15.4.1-15.4.28. PMID 25640893 DOI: 10.1002/0471140864.ps1504s79  1
2015 Palsuledesai CC, Distefano MD. Protein prenylation: enzymes, therapeutics, and biotechnology applications. Acs Chemical Biology. 10: 51-62. PMID 25402849 DOI: 10.1021/cb500791f  1
2015 Wickramaratne S, Boldry EJ, Buehler C, Wang YC, Distefano MD, Tretyakova NY. Error-prone translesion synthesis past DNA-peptide cross-links conjugated to the major groove of DNA via C5 of thymidine. The Journal of Biological Chemistry. 290: 775-87. PMID 25391658 DOI: 10.1074/jbc.M114.613638  1
2014 Wang YC, Distefano MD. Synthesis and screening of peptide libraries with free C-termini. Current Topics in Peptide & Protein Research. 15: 1-23. PMID 28239240  1
2014 Dozier JK, Khatwani SL, Wollack JW, Wang YC, Schmidt-Dannert C, Distefano MD. Engineering protein farnesyltransferase for enzymatic protein labeling applications. Bioconjugate Chemistry. 25: 1203-12. PMID 24946229 DOI: 10.1021/bc500240p  1
2014 Yeo JE, Wickramaratne S, Khatwani S, Wang YC, Vervacke J, Distefano MD, Tretyakova NY. Synthesis of site-specific DNA-protein conjugates and their effects on DNA replication. Acs Chemical Biology. 9: 1860-8. PMID 24918113 DOI: 10.1021/cb5001795  1
2014 Wollack JW, Monson BJ, Dozier JK, Dalluge JJ, Poss K, Hilderbrand SA, Distefano MD. Site-specific labeling of proteins and peptides with trans-cyclooctene containing handles capable of tetrazine ligation. Chemical Biology & Drug Design. 84: 140-7. PMID 24899362 DOI: 10.1111/cbdd.12303  1
2014 Wang YC, Dozier JK, Beese LS, Distefano MD. Rapid analysis of protein farnesyltransferase substrate specificity using peptide libraries and isoprenoid diphosphate analogues. Acs Chemical Biology. 9: 1726-35. PMID 24841702 DOI: 10.1021/cb5002312  1
2014 Pravetoni M, Vervacke JS, Distefano MD, Tucker AM, Laudenbach M, Pentel PR. Effect of currently approved carriers and adjuvants on the pre-clinical efficacy of a conjugate vaccine against oxycodone in mice and rats. Plos One. 9: e96547. PMID 24797666 DOI: 10.1371/journal.pone.0096547  1
2014 Palsuledesai CC, Ochocki JD, Markowski TW, Distefano MD. A combination of metabolic labeling and 2D-DIGE analysis in response to a farnesyltransferase inhibitor facilitates the discovery of new prenylated proteins. Molecular Biosystems. 10: 1094-103. PMID 24577581 DOI: 10.1039/c3mb70593e  1
2014 Vervacke JS, Funk AL, Wang YC, Strom M, Hrycyna CA, Distefano MD. Diazirine-containing photoactivatable isoprenoid: synthesis and application in studies with isoprenylcysteine carboxyl methyltransferase. The Journal of Organic Chemistry. 79: 1971-8. PMID 24502619 DOI: 10.1021/jo402600b  1
2014 Schuld NJ, Vervacke JS, Lorimer EL, Simon NC, Hauser AD, Barbieri JT, Distefano MD, Williams CL. The chaperone protein SmgGDS interacts with small GTPases entering the prenylation pathway by recognizing the last amino acid in the CAAX motif. The Journal of Biological Chemistry. 289: 6862-76. PMID 24415755 DOI: 10.1074/jbc.M113.527192  1
2014 Ochocki JD, Igbavboa U, Wood WG, Arriaga EA, Wattenberg EV, Distefano MD. Evaluation of prenylated peptides for use in cellular imaging and biochemical analysis. Methods in Molecular Biology (Clifton, N.J.). 1088: 213-23. PMID 24146406 DOI: 10.1007/978-1-62703-673-3_14  1
2013 Ochocki JD, Distefano MD. Prenyltransferase Inhibitors: Treating Human Ailments from Cancer to Parasitic Infections. Medchemcomm. 4: 476-492. PMID 25530833 DOI: 10.1039/C2MD20299A  1
2013 Tolstyka ZP, Richardson W, Bat E, Stevens CJ, Parra DP, Dozier JK, Distefano MD, Dunn B, Maynard HD. Chemoselective immobilization of proteins by microcontact printing and bio-orthogonal click reactions. Chembiochem : a European Journal of Chemical Biology. 14: 2464-71. PMID 24166802 DOI: 10.1002/cbic.201300478  1
2013 Rashidian M, Kumarapperuma SC, Gabrielse K, Fegan A, Wagner CR, Distefano MD. Simultaneous dual protein labeling using a triorthogonal reagent. Journal of the American Chemical Society. 135: 16388-96. PMID 24134212 DOI: 10.1021/ja403813b  1
2013 Mahmoodi MM, Rashidian M, Dozier JK, Distefano MD. Chemoenzymatic site-specific reversible immobilization and labeling of proteins from crude cellular extract without prior purification using oxime and hydrazine ligation. Current Protocols in Chemical Biology. 5: 89-109. PMID 23839992 DOI: 10.1002/9780470559277.ch120247  1
2013 Rashidian M, Dozier JK, Distefano MD. Enzymatic labeling of proteins: techniques and approaches. Bioconjugate Chemistry. 24: 1277-94. PMID 23837885 DOI: 10.1021/bc400102w  1
2013 Wang H, Henry O, Distefano MD, Wang YC, Räikkönen J, Mönkkönen J, Tanaka Y, Morita CT. Butyrophilin 3A1 plays an essential role in prenyl pyrophosphate stimulation of human Vγ2Vδ2 T cells. Journal of Immunology (Baltimore, Md. : 1950). 191: 1029-42. PMID 23833237 DOI: 10.4049/jimmunol.1300658  1
2013 Satori CP, Henderson MM, Krautkramer EA, Kostal V, Distefano MD, Distefano MM, Arriaga EA. Bioanalysis of eukaryotic organelles. Chemical Reviews. 113: 2733-811. PMID 23570618 DOI: 10.1021/cr300354g  1
2013 Rashidian M, Mahmoodi MM, Shah R, Dozier JK, Wagner CR, Distefano MD. A highly efficient catalyst for oxime ligation and hydrazone-oxime exchange suitable for bioconjugation. Bioconjugate Chemistry. 24: 333-42. PMID 23425124 DOI: 10.1021/bc3004167  1
2013 Vervacke JS, Wang YC, Distefano MD. Photoactive analogs of farnesyl diphosphate and related isoprenoids: design and applications in studies of medicinally important isoprenoid-utilizing enzymes. Current Medicinal Chemistry. 20: 1585-94. PMID 23409719 DOI: 10.2174/0929867311320120008  1
2012 Diaz-Rodriguez V, Mullen DG, Ganusova E, Becker JM, Distefano MD. Synthesis of peptides containing C-terminal methyl esters using trityl side-chain anchoring: application to the synthesis of a-factor and a-factor analogs. Organic Letters. 14: 5648-51. PMID 23121562 DOI: 10.1021/ol302592v  1
2012 Wang YC, Distefano MD. Solid-phase synthesis of C-terminal peptide libraries for studying the specificity of enzymatic protein prenylation. Chemical Communications (Cambridge, England). 48: 8228-30. PMID 22783549 DOI: 10.1039/c2cc31713c  1
2012 Khatwani SL, Kang JS, Mullen DG, Hast MA, Beese LS, Distefano MD, Taton TA. Covalent protein-oligonucleotide conjugates by copper-free click reaction. Bioorganic & Medicinal Chemistry. 20: 4532-9. PMID 22682299 DOI: 10.1016/j.bmc.2012.05.017  1
2012 Hahne K, Vervacke JS, Shrestha L, Donelson JL, Gibbs RA, Distefano MD, Hrycyna CA. Evaluation of substrate and inhibitor binding to yeast and human isoprenylcysteine carboxyl methyltransferases (Icmts) using biotinylated benzophenone-containing photoaffinity probes. Biochemical and Biophysical Research Communications. 423: 98-103. PMID 22634004 DOI: 10.1016/j.bbrc.2012.05.089  1
2012 Abate-Pella D, Zeliadt NA, Ochocki JD, Warmka JK, Dore TM, Blank DA, Wattenberg EV, Distefano MD. Photochemical modulation of Ras-mediated signal transduction using caged farnesyltransferase inhibitors: activation by one- and two-photon excitation. Chembiochem : a European Journal of Chemical Biology. 13: 1009-16. PMID 22492666 DOI: 10.1002/cbic.201200063  1
2012 Rashidian M, Song JM, Pricer RE, Distefano MD. Chemoenzymatic reversible immobilization and labeling of proteins without prior purification. Journal of the American Chemical Society. 134: 8455-67. PMID 22435540 DOI: 10.1021/ja211308s  1
2012 Dozier JK, Distefano MD. An enzyme-coupled continuous fluorescence assay for farnesyl diphosphate synthases. Analytical Biochemistry. 421: 158-63. PMID 22085443 DOI: 10.1016/j.ab.2011.10.038  1
2012 Abate-Pella D, Distefano MD. Caging groups for cysteine: Synthesis and biological applications Cysteine: Biosynthesis, Chemical Structure and Toxicity. 155-171.  1
2011 Kyro K, Manandhar SP, Mullen D, Schmidt WK, Distefano MD. Photoaffinity labeling of Ras converting enzyme using peptide substrates that incorporate benzoylphenylalanine (Bpa) residues: improved labeling and structural implications. Bioorganic & Medicinal Chemistry. 19: 7559-69. PMID 22079863 DOI: 10.1016/j.bmc.2011.10.027  1
2011 Gaffarogullari EC, Masterson LR, Metcalfe EE, Traaseth NJ, Balatri E, Musa MM, Mullen D, Distefano MD, Veglia G. A myristoyl/phosphoserine switch controls cAMP-dependent protein kinase association to membranes. Journal of Molecular Biology. 411: 823-36. PMID 21740913 DOI: 10.1016/j.jmb.2011.06.034  1
2011 Ochocki JD, Mullen DG, Wattenberg EV, Distefano MD. Evaluation of a cell penetrating prenylated peptide lacking an intrinsic fluorophore via in situ click reaction. Bioorganic & Medicinal Chemistry Letters. 21: 4998-5001. PMID 21632248 DOI: 10.1016/j.bmcl.2011.04.138  1
2011 Mullen DG, Kyro K, Hauser M, Gustavsson M, Veglia G, Becker JM, Naider F, Distefano MD. Synthesis of a-factor peptide from Saccharomyces cerevisiae and photoactive analogues via Fmoc solid phase methodology. Bioorganic & Medicinal Chemistry. 19: 490-7. PMID 21134758 DOI: 10.1016/j.bmc.2010.11.006  1
2011 Lenevich S, Distefano MD. Nuclear magnetic resonance-based quantification of organic diphosphates. Analytical Biochemistry. 408: 316-20. PMID 20833124 DOI: 10.1016/j.ab.2010.08.030  1
2010 DeGraw AJ, Palsuledesai C, Ochocki JD, Dozier JK, Lenevich S, Rashidian M, Distefano MD. Evaluation of alkyne-modified isoprenoids as chemical reporters of protein prenylation. Chemical Biology & Drug Design. 76: 460-71. PMID 21040496 DOI: 10.1111/j.1747-0285.2010.01037.x  1
2010 Rashidian M, Dozier JK, Lenevich S, Distefano MD. Selective labeling of polypeptides using protein farnesyltransferase via rapid oxime ligation. Chemical Communications (Cambridge, England). 46: 8998-9000. PMID 20967387 DOI: 10.1039/c0cc03305g  1
2010 Kyro K, Manandhar SP, Mullen D, Schmidt WK, Distefano MD. Photoaffinity labeling of Ras converting enzyme 1 (Rce1p) using a benzophenone-containing peptide substrate. Bioorganic & Medicinal Chemistry. 18: 5675-84. PMID 20619662 DOI: 10.1016/j.bmc.2010.06.024  1
2010 Ochocki JD, Igbavboa U, Gibson Wood W, Wattenberg EV, Distefano MD. Enlarging the scope of cell-penetrating prenylated peptides to include farnesylated 'CAAX' box sequences and diverse cell types. Chemical Biology & Drug Design. 76: 107-15. PMID 20584014 DOI: 10.1111/j.1747-0285.2010.00992.x  1
2010 Lopez-Gallego F, Agger SA, Abate-Pella D, Distefano MD, Schmidt-Dannert C. Sesquiterpene synthases Cop4 and Cop6 from Coprinus cinereus: catalytic promiscuity and cyclization of farnesyl pyrophosphate geometric isomers. Chembiochem : a European Journal of Chemical Biology. 11: 1093-106. PMID 20419721 DOI: 10.1002/cbic.200900671  1
2010 Mullen DG, Weigel B, Barany G, Distefano MD. On-resin conversion of Cys(Acm)-containing peptides to their corresponding Cys(Scm) congeners. Journal of Peptide Science : An Official Publication of the European Peptide Society. 16: 219-22. PMID 20401923 DOI: 10.1002/psc.1223  1
2010 DeGraw AJ, Keiser MJ, Ochocki JD, Shoichet BK, Distefano MD. Prediction and evaluation of protein farnesyltransferase inhibition by commercial drugs. Journal of Medicinal Chemistry. 53: 2464-71. PMID 20180535 DOI: 10.1021/jm901613f  1
2010 Wollack JW, Zeliadt NA, Ochocki JD, Mullen DG, Barany G, Wattenberg EV, Distefano MD. Investigation of the sequence and length dependence for cell-penetrating prenylated peptides. Bioorganic & Medicinal Chemistry Letters. 20: 161-3. PMID 20004573 DOI: 10.1016/j.bmcl.2009.11.026  1
2010 Hovlid ML, Edelstein RL, Henry O, Ochocki J, DeGraw A, Lenevich S, Talbot T, Young VG, Hruza AW, Lopez-Gallego F, Labello NP, Strickland CL, Schmidt-Dannert C, Distefano MD. Synthesis, properties, and applications of diazotrifluropropanoyl-containing photoactive analogs of farnesyl diphosphate containing modified linkages for enhanced stability. Chemical Biology & Drug Design. 75: 51-67. PMID 19954434 DOI: 10.1111/j.1747-0285.2009.00914.x  1
2009 Wollack JW, Silverman JM, Petzold CJ, Mougous JD, Distefano MD. A minimalist substrate for enzymatic peptide and protein conjugation. Chembiochem : a European Journal of Chemical Biology. 10: 2934-43. PMID 19856367 DOI: 10.1002/cbic.200900566  1
2009 Henry O, Lopez-Gallego F, Agger SA, Schmidt-Dannert C, Sen S, Shintani D, Cornish K, Distefano MD. A versatile photoactivatable probe designed to label the diphosphate binding site of farnesyl diphosphate utilizing enzymes. Bioorganic & Medicinal Chemistry. 17: 4797-805. PMID 19447628 DOI: 10.1016/j.bmc.2009.04.034  1
2009 Wollack JW, Zeliadt NA, Mullen DG, Amundson G, Geier S, Falkum S, Wattenberg EV, Barany G, Distefano MD. Multifunctional prenylated peptides for live cell analysis. Journal of the American Chemical Society. 131: 7293-303. PMID 19425596 DOI: 10.1021/ja805174z  1
2009 Chung JA, Wollack JW, Hovlid ML, Okesli A, Chen Y, Mueller JD, Distefano MD, Taton TA. Purification of prenylated proteins by affinity chromatography on cyclodextrin-modified agarose. Analytical Biochemistry. 386: 1-8. PMID 18834849 DOI: 10.1016/j.ab.2008.09.007  1
2009 Sarikonda G, Wang H, Puan KJ, Liu XH, Lee HK, Song Y, Distefano MD, Oldfield E, Prestwich GD, Morita CT. Photoaffinity antigens for human γδ T cells Journal of Immunology. 181: 7738-7750.  1
2008 Sarikonda G, Wang H, Puan KJ, Liu XH, Lee HK, Song Y, Distefano MD, Oldfield E, Prestwich GD, Morita CT. Photoaffinity antigens for human gammadelta T cells. Journal of Immunology (Baltimore, Md. : 1950). 181: 7738-50. PMID 19017963 DOI: 10.4049/jimmunol.181.11.7738  1
2008 DeGraw AJ, Hast MA, Xu J, Mullen D, Beese LS, Barany G, Distefano MD. Caged protein prenyltransferase substrates: tools for understanding protein prenylation. Chemical Biology & Drug Design. 72: 171-81. PMID 18844669 DOI: 10.1111/j.1747-0285.2008.00698.x  1
2008 Xie W, McMahan CM, Degraw AJ, Distefano MD, Cornish K, Whalen MC, Shintani DK. Initiation of rubber biosynthesis: In vitro comparisons of benzophenone-modified diphosphate analogues in three rubber-producing species. Phytochemistry. 69: 2539-45. PMID 18799172 DOI: 10.1016/j.phytochem.2008.07.011  1
2007 Duckworth BP, Chen Y, Wollack JW, Sham Y, Mueller JD, Taton TA, Distefano MD. A universal method for the preparation of covalent protein-DNA conjugates for use in creating protein nanostructures. Angewandte Chemie (International Ed. in English). 46: 8819-22. PMID 17935099 DOI: 10.1002/anie.200701942  1
2007 DeGraw AJ, Zhao Z, Strickland CL, Taban AH, Hsieh J, Jefferies M, Xie W, Shintani DK, McMahan CM, Cornish K, Distefano MD. A photoactive isoprenoid diphosphate analogue containing a stable phosphonate linkage: synthesis and biochemical studies with prenyltransferases. The Journal of Organic Chemistry. 72: 4587-95. PMID 17477573 DOI: 10.1021/jo0623033  1
2007 Lenevich S, Xu J, Hosokawa A, Cramer CJ, Distefano MD. Transition state analysis of model and enzymatic prenylation reactions. Journal of the American Chemical Society. 129: 5796-7. PMID 17439118 DOI: 10.1021/ja069119j  1
2007 Duckworth BP, Zhang Z, Hosokawa A, Distefano MD. Selective labeling of proteins by using protein farnesyltransferase. Chembiochem : a European Journal of Chemical Biology. 8: 98-105. PMID 17133644 DOI: 10.1002/cbic.200600340  1
2007 Hosokawa A, Wollack JW, Zhang Z, Chen L, Barany G, Distefano MD. Evaluation of an alkyne-containing analogue of farnesyl diphosphate as a dual substrate for protein-prenyltransferases International Journal of Peptide Research and Therapeutics. 13: 345-354. DOI: 10.1007/s10989-007-9090-3  1
2006 Xu J, Degraw AJ, Duckworth BP, Lenevich S, Tann CM, Jenson EC, Gruber SJ, Barany G, Distefano MD. Synthesis and reactivity of 6,7-dihydrogeranylazides: reagents for primary azide incorporation into peptides and subsequent staudinger ligation. Chemical Biology & Drug Design. 68: 85-96. PMID 16999773 DOI: 10.1111/j.1747-0285.2006.00420.x  1
2006 Duckworth BP, Xu J, Taton TA, Guo A, Distefano MD. Site-specific, covalent attachment of proteins to a solid surface. Bioconjugate Chemistry. 17: 967-74. PMID 16848404 DOI: 10.1021/bc060125e  1
2006 Duckworth B, Distefano MD. Protein-based Artificial Enzymes Artificial Enzymes. 109-132. DOI: 10.1002/3527606645.ch5  1
2005 Rose MW, Rose ND, Boggs J, Lenevich S, Xu J, Barany G, Distefano MD. Evaluation of geranylazide and farnesylazide diphosphate for incorporation of prenylazides into a CAAX box-containing peptide using protein farnesyltransferase. The Journal of Peptide Research : Official Journal of the American Peptide Society. 65: 529-37. PMID 15885112 DOI: 10.1111/j.1399-3011.2005.00261.x  1
2005 Rose MW, Xu J, Kale TA, O'Doherty G, Barany G, Distefano MD. Enzymatic incorporation of orthogonally reactive prenylazide groups into peptides using geranylazide diphosphate via protein farnesyltransferase: implications for selective protein labeling. Biopolymers. 80: 164-71. PMID 15810014 DOI: 10.1002/bip.20239  1
2005 Adams DN, Kao EY, Hypolite CL, Distefano MD, Hu WS, Letourneau PC. Growth cones turn and migrate up an immobilized gradient of the laminin IKVAV peptide. Journal of Neurobiology. 62: 134-47. PMID 15452851 DOI: 10.1002/neu.20075  1
2003 Franklin MC, Kadkhodayan S, Ackerly H, Alexandru D, Distefano MD, Elliott LO, Flygare JA, Mausisa G, Okawa DC, Ong D, Vucic D, Deshayes K, Fairbrother WJ. Structure and function analysis of peptide antagonists of melanoma inhibitor of apoptosis (ML-IAP). Biochemistry. 42: 8223-31. PMID 12846571 DOI: 10.1021/bi034227t  1
2003 Kale TA, Hsieh SA, Rose MW, Distefano MD. Use of synthetic isoprenoid analogues for understanding protein prenyltransferase mechanism and structure. Current Topics in Medicinal Chemistry. 3: 1043-74. PMID 12769708  1
2003 Turek-Etienne TC, Strickland CL, Distefano MD. Biochemical and structural studies with prenyl diphosphate analogues provide insights into isoprenoid recognition by protein farnesyl transferase. Biochemistry. 42: 3716-24. PMID 12667062 DOI: 10.1021/bi0266838  1
2003 Kale TA, Distefano MD. Diazotrifluoropropionamido-containing prenylcysteines: syntheses and applications for studying isoprenoid-protein interactions. Organic Letters. 5: 609-12. PMID 12605471 DOI: 10.1021/ol026752a  1
2003 Kale TA, Raab C, Yu N, Aquino E, Dean DC, Distefano MD. Synthesis of high specific activity 35S-labelled N-methanesulfonyl farnesylcysteine and a photoactive analog Journal of Labelled Compounds and Radiopharmaceuticals. 46: 29-54. DOI: 10.1002/jlcr.638  1
2002 Distefano MD, Zhong A, Cochran AG. Quantifying beta-sheet stability by phage display. Journal of Molecular Biology. 322: 179-88. PMID 12215423 DOI: 10.1016/S0022-2836(02)00738-6  1
2002 Häring D, Lees MR, Banaszak LJ, Distefano MD. Exploring routes to stabilize a cationic pyridoxamine in an artificial transaminase: site-directed mutagenesis versus synthetic cofactors. Protein Engineering. 15: 603-10. PMID 12200543  1
2002 Kale TA, Turek TC, Chang V, Gautam N, Distefano MD. Preparation and application of G protein gamma subunit-derived peptides incorporating a photoactive isoprenoid. Methods in Enzymology. 344: 245-58. PMID 11771387 DOI: 10.1016/S0076-6879(02)44719-2  1
2001 Tann CM, Qi D, Distefano MD. Enzyme design by chemical modification of protein scaffolds. Current Opinion in Chemical Biology. 5: 696-704. PMID 11738181 DOI: 10.1016/S1367-5931(01)00268-X  1
2001 Qi D, Tann CM, Haring D, Distefano MD. Generation of new enzymes via covalent modification of existing proteins. Chemical Reviews. 101: 3081-111. PMID 11710063 DOI: 10.1021/cr000059o  1
2001 Häring D, Distefano MD. Specific host-guest interactions in a protein-based artificial transaminase. Bioorganic & Medicinal Chemistry. 9: 2461-6. PMID 11553487 DOI: 10.1016/S0968-0896(01)00218-8  1
2001 Kale TA, Raab C, Yu N, Dean DC, Distefano MD. A photoactivatable prenylated cysteine designed to study isoprenoid recognition. Journal of the American Chemical Society. 123: 4373-81. PMID 11457220 DOI: 10.1021/ja0012016  1
2001 Häring D, Distefano MD. Enzymes by design: chemogenetic assembly of transamination active sites containing lysine residues for covalent catalysis. Bioconjugate Chemistry. 12: 385-90. PMID 11353536 DOI: 10.1021/bc000117c  1
2001 Turek TC, Gaon I, Distefano MD, Strickland CL. Synthesis of farnesyl diphosphate analogues containing ether-linked photoactive benzophenones and their application in studies of protein prenyltransferases. The Journal of Organic Chemistry. 66: 3253-64. PMID 11348105 DOI: 10.1021/jo991130x  1
2001 Clausen VA, Edelstein RL, Distefano MD. Stereochemical analysis of the reaction catalyzed by human protein geranylgeranyl transferase. Biochemistry. 40: 3920-30. PMID 11300771 DOI: 10.1021/bi002011a  1
2001 Häring D, Kuang H, Qi D, Distefano MD. Converting a fatty acid binding protein to an artificial transaminase: Novel catalysts by chemical and genetic modification of a protein cavity Journal of Molecular Catalysis - B Enzymatic. 11: 967-970. DOI: 10.1016/S1381-1177(00)00051-5  1
2000 Kuang H, Häring D, Qi D, Mazhary A, Distefano MD. Synthesis of a cationic pyridoxamine conjugation reagent and application to the mechanistic analysis of an artificial transaminase. Bioorganic & Medicinal Chemistry Letters. 10: 2091-5. PMID 10999478 DOI: 10.1016/S0960-894X(00)00419-4  1
1999 Davies RR, Kuang H, Qi D, Mazhary A, Mayaan E, Distefano MD. Artificial metalloenzymes based on protein cavities: exploring the effect of altering the metal ligand attachment position by site directed mutagenesis. Bioorganic & Medicinal Chemistry Letters. 9: 79-84. PMID 9990461 DOI: 10.1016/S0960-894X(98)00684-2  1
1998 Qi D, Kuang H, Distefano MD. Effects of metal ions on the rates and enantioselectivities of reactions catalyzed by a series of semisynthetic transaminases created by site directed mutagenesis. Bioorganic & Medicinal Chemistry Letters. 8: 875-80. PMID 9871558 DOI: 10.1016/S0960-894X(98)00129-2  1
1998 Distefano MD, Kuang H, Qi D, Mazhary A. The design of protein-based catalysts using semisynthetic methods. Current Opinion in Structural Biology. 8: 459-65. PMID 9729737 DOI: 10.1016/S0959-440X(98)80123-1  1
1998 Ory JJ, Mazhary A, Kuang H, Davies RR, Distefano MD, Banaszak LJ. Structural characterization of two synthetic catalysts based on adipocyte lipid-binding protein. Protein Engineering. 11: 253-61. PMID 9680187  1
1998 Weller VA, Distefano MD. Measurement of the α-secondary kinetic isotope effect for a prenyltransferase by MALDI mass spectrometry [2] Journal of the American Chemical Society. 120: 7975-7976. DOI: 10.1021/ja980353m  1
1998 Kuang H, Distefano MD. Catalytic enantioselective reductive amination in a host-guest system based on a protein cavity [2] Journal of the American Chemical Society. 120: 1072-1073. DOI: 10.1021/ja972771h  1
1998 Edelstein RL, Weller VA, Distefano MD, Tung JS. Stereochemical Analysis of the Reaction Catalyzed by Yeast Protein Farnesyltransferase Journal of Organic Chemistry. 63: 5298-5299.  1
1998 Tabakovic I, Gaon I, Distefano MD. Anodic oxidation of substituted [4-hydroxy-3-coumarinyl]-phenylthiomethanes in acetonitrile. Evidence for a cationic intermediate in carbon-sulfur bond fragmentation Electrochimica Acta. 43: 1773-1778.  1
1997 Herbert CB, McLernon TL, Hypolite CL, Adams DN, Pikus L, Huang CC, Fields GB, Letourneau PC, Distefano MD, Hu WS. Micropatterning gradients and controlling surface densities of photoactivatable biomolecules on self-assembled monolayers of oligo(ethylene glycol) alkanethiolates. Chemistry & Biology. 4: 731-7. PMID 9375251  1
1997 Hypolite CL, McLernon TL, Adams DN, Chapman KE, Herbert CB, Huang CC, Distefano MD, Hu WS. Formation of microscale gradients of protein using heterobifunctional photolinkers. Bioconjugate Chemistry. 8: 658-63. PMID 9327128 DOI: 10.1021/bc9701252  1
1997 Edelstein RL, Distefano MD. Photoaffinity labeling of yeast farnesyl protein transferase and enzymatic synthesis of a Ras protein incorporating a photoactive isoprenoid. Biochemical and Biophysical Research Communications. 235: 377-82. PMID 9199201 DOI: 10.1006/bbrc.1997.6792  1
1997 Davies RR, Distefano MD. A semisynthetic metalloenzyme based on a protein cavity that catalyzes the enantioselective hydrolysis of ester and amide substrates Journal of the American Chemical Society. 119: 11643-11652. DOI: 10.1021/ja970820k  1
1997 Turek TC, Gaon I, Gamache D, Distefano MD. Synthesis and evaluation of benzophenone-based photoaffinity labeling analogs of prenyl pyrophosphates containing stable amide linkages Bioorganic and Medicinal Chemistry Letters. 7: 2125-2130. DOI: 10.1016/S0960-894X(97)00373-9  1
1997 Kuang H, Davies RR, Distefano MD. Modulation of the rate, enantioselectivity, and substrate specificity of semisynthetic transaminases based on lipid binding proteins using site directed mutagenesis Bioorganic and Medicinal Chemistry Letters. 7: 2055-2060. DOI: 10.1016/S0960-894X(97)00358-2  1
1997 Turek TC, Gaon I, Distefano MD. Synthesis and rapid purification of 32P-labeled photoactive analogs of farnesyl pyrophosphate Journal of Labelled Compounds and Radiopharmaceuticals. 39: 139-146. DOI: 10.1002/(SICI)1099-1344(199702)39:2<139::AID-JLCR951>3.0.CO;2-A  1
1997 Waller VA, Turek TC, Gaon I, Distefano MD. Mechanistic and structural studies on protein prenyl transferases Faseb Journal. 11: A1086.  1
1997 Kuang H, Distefano MD. Artificial enzymes based on protein cavities: Inversion of reaction enantioselectivity by alteration of the site of catalyst attachment Protein Engineering. 10: 25.  1
1997 Turck TC, Edelstein RL, Gaon I, Singh SK, Weller V, Distefano MD. Tools for the study of prenylated proteins: Photoactive benzophenone and diazotrifluoropropionate containing molecules Protein Engineering. 10: 91.  1
1997 Ory JJ, Kuang H, Davies R, Mazhary A, Distefano MD, Banaszak LJ. Structural characterization of two artificial enzymes based on adipocyte lipid binding protein Faseb Journal. 11: A1321.  1
1997 Davies RR, Brown ML, Distefano MD. An artificial metalloenzyme based on a protein cavity that catalyzes the enantio-selective hydrolysis of amino acid esters Protein Engineering. 10: 61.  1
1997 Hypolite CL, McLernon T, Adams D, Herbert C, Huang CC, Hu WS, Distefano MD. Two-dimensional surface gradients of photoactivable R-phycoerythrin Protein Engineering. 10: 84.  1
1997 Distefano MD, Kuang H, Mazharx A, Ory J, Banaszak LJ. Artificial transaminases: Tuning the selectivity and rate of pyridoxamine catalyzed reactions in a protein cavity modified by site directed mutagenesis Faseb Journal. 11: A1325.  1
1997 Edelstein RL, Distefano MD. Photoaffinity labeling using photoreactive isoprenoid analogs Faseb Journal. 11: A1086.  1
1996 Gaon I, Turek TC, Weller VA, Edelstein RL, Singh SK, Distefano MD. Photoactive Analogs of Farnesyl Pyrophosphate Containing Benzoylbenzoate Esters: Synthesis and Application to Photoaffinity Labeling of Yeast Protein Farnesyltransferase. The Journal of Organic Chemistry. 61: 7738-7745. PMID 11667728 DOI: 10.1021/jo9602736  1
1996 Kuang H, Brown ML, Davies RR, Young EC, Distefano MD. Enantioselective reductive amination of α-keto acids to α-amino acids by a pyridoxamine cofactor in a protein cavity Journal of the American Chemical Society. 118: 10702-10706. DOI: 10.1021/ja954271z  1
1996 Gaon I, Turek TC, Distefano MD. Farnesyl and geranylgeranyl pyrophosphate analogs incorporating benzoylbenzyl ethers: Synthesis and inhibition of yeast protein farnesyltransferase Tetrahedron Letters. 37: 8833-8836. DOI: 10.1016/S0040-4039(96)02066-7  1
1996 Turek TC, Gaon I, Distefano MD. Analogs of farnesyl pyrophosphate incorporating internal benzoylbenzoate esters: Synthesis, inhibition kinetics and photoinactivation of yeast protein farnesyltransferase Tetrahedron Letters. 37: 4845-4848. DOI: 10.1016/0040-4039(96)00972-0  1
1993 Distefano MD, Dervan PB. Energetics of cooperative binding of oligonucleotides with discrete dimerization domains to DNA by triple helix formation. Proceedings of the National Academy of Sciences of the United States of America. 90: 1179-83. PMID 8433980 DOI: 10.1073/pnas.90.4.1179  1
1993 Colocci N, Distefano MD, Dervan PB. Cooperative oligonucleotide-directed triple helix formation at adjacent DNA sites Journal of the American Chemical Society. 115: 4468-4473. DOI: 10.1021/ja00064a008  1
1993 Colocci N, Distefano MD, Dervan PB. Cooperative oligonucleotide-directed triple helix formation at adjacent DNA sites Journal of the American Chemical Society. 115: 4468-4473.  1
1992 Distefano MD, Dervan PB. Ligand-promoted dimerization of oligonucleotides binding cooperatively to DNA Journal of the American Chemical Society. 114: 11006-11007. DOI: 10.1021/ja00053a073  1
1991 Schiering N, Kabsch W, Moore MJ, Distefano MD, Walsh CT, Pai EF. Structure of the detoxification catalyst mercuric ion reductase from Bacillus sp. strain RC607. Nature. 352: 168-72. PMID 2067577 DOI: 10.1038/352168a0  1
1991 Distefano MD, Shin JA, Dervan PB. Cooperative binding of oligonucleotides to DNA by triple helix formation: dimerization via Watson-Crick hydrogen bonds Journal of the American Chemical Society. 113: 5901-5902. DOI: 10.1021/ja00015a076  1
1991 Distefano MD, Shin JA, Dervan PB. Cooperative binding of oligonucleotides to DNA by triple helix formation: Dimerization via Watson-Crick hydrogen bonds Journal of the American Chemical Society. 113: 5901-5902.  1
1990 Miller SM, Massey V, Ballou D, Williams CH, Distefano MD, Moore MJ, Walsh CT. Use of a site-directed triple mutant to trap intermediates: demonstration that the flavin C(4a)-thiol adduct and reduced flavin are kinetically competent intermediates in mercuric ion reductase. Biochemistry. 29: 2831-41. PMID 2189497  1
1990 Distefano MD, Moore MJ, Walsh CT. Active site of mercuric reductase resides at the subunit interface and requires Cys135 and Cys140 from one subunit and Cys558 and Cys559 from the adjacent subunit: evidence from in vivo and in vitro heterodimer formation. Biochemistry. 29: 2703-13. PMID 2189495  1
1990 Moore MJ, Distefano MD, Zydowsky LD, Cummings RT, Walsh CT. Organomercurial lyase and mercuric ion reductase: nature's mercury detoxification catalysts Accounts of Chemical Research. 23: 301-308. DOI: 10.1021/ar00177a006  0.92
1990 MOORE MJ, DISTEFANO MD, ZYDOWSKY LD, CUMMINGS RT, WALSH CT. ChemInform Abstract: Organomercurial Lyase and Mercuric Ion Reductase: Nature′s Mercury Detoxification Catalysts Cheminform. 21. DOI: 10.1002/chin.199052385  0.92
1990 Moore MJ, Distefano MD, Zydowsky LD, Cummings RT, Walsh CT. Organomercurial lyase and mercuric ion reductase: Nature's mercury detoxification catalysts Accounts of Chemical Research. 23: 301-308.  1
1990 Raybuck SA, Distefano MD, Teo BK, Orme-Johnson W, Walsh CT. An EXAFS investigation of Hg(II) binding to mercuric reductase: Comparative analysis of the wild-type enzyme and a mutant enzyme generated by site-directed mutagenesis Journal of the American Chemical Society. 112: 1983-1989.  1
1989 Moore MJ, Distefano MD, Walsh CT, Schiering N, Pai EF. Purification, crystallization, and preliminary x-ray diffraction studies of the flavoenzyme mercuric ion reductase from Bacillus sp. strain RC607. The Journal of Biological Chemistry. 264: 14386-8. PMID 2668287  1
1989 Miller SM, Moore MJ, Massey V, Williams CH, Distefano MD, Ballou DP, Walsh CT. Evidence for the participation of Cys558 and Cys559 at the active site of mercuric reductase. Biochemistry. 28: 1194-205. PMID 2653437  1
1989 Distefano MD, Au KG, Walsh CT. Mutagenesis of the redox-active disulfide in mercuric ion reductase: catalysis by mutant enzymes restricted to flavin redox chemistry. Biochemistry. 28: 1168-83. PMID 2653436  1
1988 Walsh CT, Distefano MD, Moore MJ, Shewchuk LM, Verdine GL. Molecular basis of bacterial resistance to organomercurial and inorganic mercuric salts. Faseb Journal : Official Publication of the Federation of American Societies For Experimental Biology. 2: 124-30. PMID 3277886  1
1987 Neidhart DJ, Distefano MD, Tanizawa K, Soda K, Walsh CT, Petsko GA. X-ray crystallographic studies of the alanine-specific racemase from Bacillus stearothermophilus. Overproduction, crystallization, and preliminary characterization. The Journal of Biological Chemistry. 262: 15323-6. PMID 3680197  1
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