| Year |
Citation |
Score |
| 2016 |
Kyriakides M, Maitre L, Stamper BD, Mohar I, Kavanagh TJ, Foster J, Wilson ID, Holmes E, Nelson SD, Coen M. Comparative metabonomic analysis of hepatotoxicity induced by acetaminophen and its less toxic meta-isomer. Archives of Toxicology. PMID 26746206 DOI: 10.1007/S00204-015-1655-X |
0.756 |
|
| 2015 |
Stamper BD, Garcia ML, Nguyen DQ, Beyer RP, Bammler TK, Farin FM, Kavanagh TJ, Nelson SD. p53 Contributes to Differentiating Gene Expression Following Exposure to Acetaminophen and Its Less Hepatotoxic Regioisomer Both In Vitro and In Vivo. Gene Regulation and Systems Biology. 9: 1-14. PMID 26056430 DOI: 10.4137/Grsb.S25388 |
0.743 |
|
| 2014 |
Tay S, Le H, Ford KA, Nelson SD, Khojasteh SC, Rademacher PM. Mechanistic studies of the cationic binding pocket of CYP2C9 in vitro and in silico: metabolism of nonionizable analogs of tienilic acid. Drug Metabolism and Disposition: the Biological Fate of Chemicals. 42: 1955-63. PMID 25187484 DOI: 10.1124/Dmd.114.059022 |
0.648 |
|
| 2014 |
Mohar I, Stamper BD, Rademacher PM, White CC, Nelson SD, Kavanagh TJ. Acetaminophen-induced liver damage in mice is associated with gender-specific adduction of peroxiredoxin-6. Redox Biology. 2: 377-87. PMID 24563856 DOI: 10.1016/J.Redox.2014.01.008 |
0.723 |
|
| 2014 |
Hardy KD, Wahlin MD, Papageorgiou I, Unadkat JD, Rettie AE, Nelson SD. Studies on the role of metabolic activation in tyrosine kinase inhibitor-dependent hepatotoxicity: induction of CYP3A4 enhances the cytotoxicity of lapatinib in HepaRG cells. Drug Metabolism and Disposition: the Biological Fate of Chemicals. 42: 162-71. PMID 24191259 DOI: 10.1124/Dmd.113.054817 |
0.597 |
|
| 2012 |
Zhao C, Gao Q, Roberts AG, Shaffer SA, Doneanu CE, Xue S, Goodlett DR, Nelson SD, Atkins WM. Cross-linking mass spectrometry and mutagenesis confirm the functional importance of surface interactions between CYP3A4 and holo/apo cytochrome b(5). Biochemistry. 51: 9488-500. PMID 23150942 DOI: 10.1021/Bi301069R |
0.537 |
|
| 2012 |
Khojasteh SC, Hartley DP, Ford KA, Uppal H, Oishi S, Nelson SD. Characterization of rat liver proteins adducted by reactive metabolites of menthofuran. Chemical Research in Toxicology. 25: 2301-9. PMID 23106769 DOI: 10.1021/Tx300144D |
0.674 |
|
| 2012 |
Coen M, Rademacher PM, Zou W, Scott M, Ganey PE, Roth R, Nelson SD. Comparative NMR-based metabonomic investigation of the metabolic phenotype associated with tienilic acid and tienilic acid isomer. Chemical Research in Toxicology. 25: 2412-22. PMID 23013248 DOI: 10.1021/Tx3002803 |
0.357 |
|
| 2012 |
Harrelson JP, Stamper BD, Chapman JD, Goodlett DR, Nelson SD. Covalent modification and time-dependent inhibition of human CYP2E1 by the meta-isomer of acetaminophen. Drug Metabolism and Disposition: the Biological Fate of Chemicals. 40: 1460-5. PMID 22613176 DOI: 10.1124/Dmd.112.045492 |
0.781 |
|
| 2012 |
Chan EC, New LS, Chua TB, Yap CW, Ho HK, Nelson SD. Interaction of lapatinib with cytochrome P450 3A5. Drug Metabolism and Disposition: the Biological Fate of Chemicals. 40: 1414-22. PMID 22511346 DOI: 10.1124/Dmd.112.044958 |
0.626 |
|
| 2012 |
Takakusa H, Mohar I, Kavanagh TJ, Kelly EJ, Kaspera R, Nelson SD. Protein tyrosine nitration of mitochondrial carbamoyl phosphate synthetase 1 and its functional consequences. Biochemical and Biophysical Research Communications. 420: 54-60. PMID 22402285 DOI: 10.1016/J.Bbrc.2012.02.114 |
0.353 |
|
| 2012 |
Rademacher PM, Woods CM, Huang Q, Szklarz GD, Nelson SD. Differential oxidation of two thiophene-containing regioisomers to reactive metabolites by cytochrome P450 2C9. Chemical Research in Toxicology. 25: 895-903. PMID 22329513 DOI: 10.1021/Tx200519D |
0.383 |
|
| 2012 |
Wang Z, Lin YS, Zheng XE, Senn T, Hashizume T, Scian M, Dickmann LJ, Nelson SD, Baillie TA, Hebert MF, Blough D, Davis CL, Thummel KE. An inducible cytochrome P450 3A4-dependent vitamin D catabolic pathway. Molecular Pharmacology. 81: 498-509. PMID 22205755 DOI: 10.1124/Mol.111.076356 |
0.314 |
|
| 2012 |
Roberts AG, Yang J, Halpert JR, Nelson SD, Thummel KT, Atkins WM. Correction to The Structural Basis for Homotropic and Heterotropic Cooperativity of Midazolam Metabolism by Human Cytochrome P450 3A4 Biochemistry. 51: 1332-1332. DOI: 10.1021/Bi300045B |
0.332 |
|
| 2011 |
Roberts AG, Yang J, Halpert JR, Nelson SD, Thummel KT, Atkins WM. The structural basis for homotropic and heterotropic cooperativity of midazolam metabolism by human cytochrome P450 3A4. Biochemistry. 50: 10804-18. PMID 21992114 DOI: 10.1021/Bi200924T |
0.33 |
|
| 2011 |
Takakusa H, Wahlin MD, Zhao C, Hanson KL, New LS, Chan EC, Nelson SD. Metabolic intermediate complex formation of human cytochrome P450 3A4 by lapatinib. Drug Metabolism and Disposition: the Biological Fate of Chemicals. 39: 1022-30. PMID 21363997 DOI: 10.1124/Dmd.110.037531 |
0.59 |
|
| 2011 |
Stamper BD, Mohar I, Kavanagh TJ, Nelson SD. Proteomic analysis of acetaminophen-induced changes in mitochondrial protein expression using spectral counting. Chemical Research in Toxicology. 24: 549-58. PMID 21329376 DOI: 10.1021/Tx1004198 |
0.748 |
|
| 2011 |
Ortiz de Montellano PR, Nelson SD. Rearrangement reactions catalyzed by cytochrome P450s. Archives of Biochemistry and Biophysics. 507: 95-110. PMID 20971058 DOI: 10.1016/J.Abb.2010.10.016 |
0.324 |
|
| 2010 |
Khojasteh SC, Oishi S, Nelson SD. Metabolism and toxicity of menthofuran in rat liver slices and in rats. Chemical Research in Toxicology. 23: 1824-32. PMID 20945912 DOI: 10.1021/Tx100268G |
0.683 |
|
| 2010 |
Teng WC, Oh JW, New LS, Wahlin MD, Nelson SD, Ho HK, Chan EC. Mechanism-based inactivation of cytochrome P450 3A4 by lapatinib. Molecular Pharmacology. 78: 693-703. PMID 20624855 DOI: 10.1124/Mol.110.065839 |
0.625 |
|
| 2010 |
Stamper BD, Bammler TK, Beyer RP, Farin FM, Nelson SD. Differential regulation of mitogen-activated protein kinase pathways by acetaminophen and its nonhepatotoxic regioisomer 3'-hydroxyacetanilide in TAMH cells. Toxicological Sciences : An Official Journal of the Society of Toxicology. 116: 164-73. PMID 20363829 DOI: 10.1093/Toxsci/Kfq100 |
0.723 |
|
| 2008 |
Wen B, Coe KJ, Rademacher P, Fitch WL, Monshouwer M, Nelson SD. Comparison of in vitro bioactivation of flutamide and its cyano analogue: evidence for reductive activation by human NADPH:cytochrome P450 reductase. Chemical Research in Toxicology. 21: 2393-406. PMID 19548358 DOI: 10.1021/Tx800281H |
0.401 |
|
| 2008 |
Wen B, Ma L, Nelson SD, Zhu M. High-throughput screening and characterization of reactive metabolites using polarity switching of hybrid triple quadrupole linear ion trap mass spectrometry. Analytical Chemistry. 80: 1788-99. PMID 18251522 DOI: 10.1021/Ac702232R |
0.338 |
|
| 2008 |
Harrelson JP, Atkins WM, Nelson SD. Multiple-ligand binding in CYP2A6: probing mechanisms of cytochrome P450 cooperativity by assessing substrate dynamics. Biochemistry. 47: 2978-88. PMID 18247580 DOI: 10.1021/Bi702020Y |
0.766 |
|
| 2007 |
Kostrubsky SE, Strom SC, Ellis E, Nelson SD, Mutlib AE. Transport, metabolism, and hepatotoxicity of flutamide, drug-drug interaction with acetaminophen involving phase I and phase II metabolites. Chemical Research in Toxicology. 20: 1503-12. PMID 17900172 DOI: 10.1021/Tx7001542 |
0.388 |
|
| 2007 |
Cameron MD, Wen B, Roberts AG, Atkins WM, Campbell AP, Nelson SD. Cooperative binding of acetaminophen and caffeine within the P450 3A4 active site. Chemical Research in Toxicology. 20: 1434-41. PMID 17894464 DOI: 10.1021/Tx7000702 |
0.339 |
|
| 2007 |
Coe KJ, Jia Y, Ho HK, Rademacher P, Bammler TK, Beyer RP, Farin FM, Woodke L, Plymate SR, Fausto N, Nelson SD. Comparison of the cytotoxicity of the nitroaromatic drug flutamide to its cyano analogue in the hepatocyte cell line TAMH: evidence for complex I inhibition and mitochondrial dysfunction using toxicogenomic screening. Chemical Research in Toxicology. 20: 1277-90. PMID 17702527 DOI: 10.1021/Tx7001349 |
0.577 |
|
| 2007 |
Harrelson JP, Henne KR, Alonso DO, Nelson SD. A comparison of substrate dynamics in human CYP2E1 and CYP2A6. Biochemical and Biophysical Research Communications. 352: 843-9. PMID 17156750 DOI: 10.1016/J.Bbrc.2006.11.071 |
0.742 |
|
| 2006 |
Mutlib A, Jiang P, Atherton J, Obert L, Kostrubsky S, Madore S, Nelson S. Identification of potential genomic biomarkers of hepatotoxicity caused by reactive metabolites of N-methylformamide: Application of stable isotope labeled compounds in toxicogenomic studies. Chemical Research in Toxicology. 19: 1270-1283. PMID 17040096 DOI: 10.1021/Tx060093J |
0.304 |
|
| 2006 |
Wen B, Lampe JN, Roberts AG, Atkins WM, David Rodrigues A, Nelson SD. Cysteine 98 in CYP3A4 contributes to conformational integrity required for P450 interaction with CYP reductase. Archives of Biochemistry and Biophysics. 454: 42-54. PMID 16959210 DOI: 10.1016/J.Abb.2006.08.003 |
0.346 |
|
| 2006 |
Gao Q, Doneanu CE, Shaffer SA, Adman ET, Goodlett DR, Nelson SD. Identification of the interactions between cytochrome P450 2E1 and cytochrome b5 by mass spectrometry and site-directed mutagenesis. The Journal of Biological Chemistry. 281: 20404-17. PMID 16679316 DOI: 10.1074/Jbc.M601785200 |
0.321 |
|
| 2006 |
Ho HK, Jia Y, Coe KJ, Gao Q, Doneanu CE, Hu Z, Bammler TK, Beyer RP, Fausto N, Bruschi SA, Nelson SD. Cytosolic heat shock proteins and heme oxygenase-1 are preferentially induced in response to specific and localized intramitochondrial damage by tetrafluoroethylcysteine. Biochemical Pharmacology. 72: 80-90. PMID 16678137 DOI: 10.1016/J.Bcp.2006.03.019 |
0.534 |
|
| 2005 |
Wen B, Doneanu CE, Lampe JN, Roberts AG, Atkins WM, Nelson SD. Probing the CYP3A4 active site by cysteine scanning mutagenesis and photoaffinity labeling. Archives of Biochemistry and Biophysics. 444: 100-11. PMID 16289363 DOI: 10.1016/J.Abb.2005.09.010 |
0.301 |
|
| 2005 |
Cameron MD, Wen B, Allen KE, Roberts AG, Schuman JT, Campbell AP, Kunze KL, Nelson SD. Cooperative binding of midazolam with testosterone and alpha-naphthoflavone within the CYP3A4 active site: a NMR T1 paramagnetic relaxation study. Biochemistry. 44: 14143-51. PMID 16245930 DOI: 10.1021/Bi051689T |
0.325 |
|
| 2005 |
Regal KA, Kunze KL, Peter RM, Nelson SD. Oxidation of caffeine by CYP1A2: isotope effects and metabolic switching. Drug Metabolism and Disposition: the Biological Fate of Chemicals. 33: 1837-44. PMID 16135658 DOI: 10.1124/Dmd.105.006031 |
0.375 |
|
| 2005 |
Welch KD, Wen B, Goodlett DR, Yi EC, Lee H, Reilly TP, Nelson SD, Pohl LR. Proteomic identification of potential susceptibility factors in drug-induced liver disease. Chemical Research in Toxicology. 18: 924-33. PMID 15962927 DOI: 10.1021/Tx050011B |
0.311 |
|
| 2005 |
Ho HK, White CC, Fernandez C, Fausto N, Kavanagh TJ, Nelson SD, Bruschi SA. Nrf2 activation involves an oxidative-stress independent pathway in tetrafluoroethylcysteine-induced cytotoxicity. Toxicological Sciences : An Official Journal of the Society of Toxicology. 86: 354-64. PMID 15901913 DOI: 10.1093/Toxsci/Kfi205 |
0.572 |
|
| 2005 |
Gartner CA, Wen B, Wan J, Becker RS, Jones G, Gygi SP, Nelson SD. Photochromic agents as tools for protein structure study: lapachenole is a photoaffinity ligand of cytochrome P450 3A4. Biochemistry. 44: 1846-55. PMID 15697210 DOI: 10.1021/Bi049231Z |
0.775 |
|
| 2005 |
Wen B, Doneanu CE, Gartner CA, Roberts AG, Atkins WM, Nelson SD. Fluorescent photoaffinity labeling of cytochrome P450 3A4 by lapachenole: identification of modification sites by mass spectrometry. Biochemistry. 44: 1833-45. PMID 15697209 DOI: 10.1021/Bi048228C |
0.745 |
|
| 2005 |
Ho HK, Hu ZH, Tzung SP, Hockenbery DM, Fausto N, Nelson SD, Bruschi SA. BCL-xL overexpression effectively protects against tetrafluoroethylcysteine-induced intramitochondrial damage and cell death. Biochemical Pharmacology. 69: 147-57. PMID 15588723 DOI: 10.1016/J.Bcp.2004.08.030 |
0.549 |
|
| 2003 |
Nelson SD, Trager WF. The use of deuterium isotope effects to probe the active site properties, mechanism of cytochrome P450-catalyzed reactions, and mechanisms of metabolically dependent toxicity. Drug Metabolism and Disposition: the Biological Fate of Chemicals. 31: 1481-98. PMID 14625345 DOI: 10.1124/Dmd.31.12.1481 |
0.606 |
|
| 2003 |
Nelson SD, Slattery JT, Thummel KE, Watkins PB. Car unlikely to significantly modulate acetaminophen hepatotoxicity in most humans Hepatology. 38: 254-257. DOI: 10.1002/Hep.510380133 |
0.313 |
|
| 2002 |
Pierce RH, Franklin CC, Campbell JS, Tonge RP, Chen W, Fausto N, Nelson SD, Bruschi SA. Cell culture model for acetaminophen-induced hepatocyte death in vivo. Biochemical Pharmacology. 64: 413-24. PMID 12147292 DOI: 10.1016/S0006-2952(02)01180-2 |
0.343 |
|
| 2002 |
James EA, Gygi SP, Adams ML, Pierce RH, Fausto N, Aebersold RH, Nelson SD, Bruschi SA. Mitochondrial aconitase modification, functional inhibition, and evidence for a supramolecular complex of the TCA cycle by the renal toxicant S-(1,1,2,2-tetrafluoroethyl)-L-cysteine. Biochemistry. 41: 6789-97. PMID 12022883 DOI: 10.1021/Bi020038J |
0.477 |
|
| 2001 |
Adams ML, Pierce RH, Vail ME, White CC, Tonge RP, Kavanagh TJ, Fausto N, Nelson SD, Bruschi SA. Enhanced acetaminophen hepatotoxicity in transgenic mice overexpressing BCL-2. Molecular Pharmacology. 60: 907-15. PMID 11641418 DOI: 10.1124/Mol.60.5.907 |
0.325 |
|
| 2001 |
Gartner CA, Thompson SJ, Rettie AE, Nelson SD. Human aromatase in high yield and purity by perfusion chromatography and its characterization by difference spectroscopy and mass spectrometry. Protein Expression and Purification. 22: 443-54. PMID 11483007 DOI: 10.1006/Prep.2001.1464 |
0.785 |
|
| 2001 |
Nelson SD. Molecular mechanisms of adverse drug reactions Current Therapeutic Research - Clinical and Experimental. 62: 885-899. DOI: 10.1016/S0011-393X(01)80093-X |
0.337 |
|
| 2000 |
Regal KA, Nelson SD. Orientation of caffeine within the active site of human cytochrome P450 1A2 based on NMR longitudinal (T1) relaxation measurements Archives of Biochemistry and Biophysics. 384: 47-58. PMID 11147835 DOI: 10.1006/Abbi.2000.2073 |
0.348 |
|
| 1999 |
Khojasteh-Bakht SC, Nelson SD, Atkins WM. Glutathione S-transferase catalyzes the isomerization of (R)-2- hydroxymenthofuran to mintlactones Archives of Biochemistry and Biophysics. 370: 59-65. PMID 10496977 DOI: 10.1006/Abbi.1999.1361 |
0.364 |
|
| 1999 |
Chen W, Shockcor JP, Tonge R, Hunter A, Gartner C, Nelson SD. Protein and nonprotein cysteinyl thiol modification by N-acetyl-p- benzoquinone imine via a novel Ipso adduct Biochemistry. 38: 8159-8166. PMID 10387061 DOI: 10.1021/Bi990125K |
0.407 |
|
| 1998 |
Tonge RP, Kelly EJ, Bruschi SA, Kalhorn T, Eaton DL, Nebert DW, Nelson SD. Role of CYP1A2 in the hepatotoxicity of acetaminophen: Investigations using Cyp1a2 null mice Toxicology and Applied Pharmacology. 153: 102-108. PMID 9875304 DOI: 10.1006/Taap.1998.8543 |
0.378 |
|
| 1998 |
Khojasteh-Bakht SC, Koenigs LL, Peter RM, Trager WF, Nelson SD. (R)-(+)-Menthofuran is a potent, mechanism-based inactivator of human liver cytochrome P450 2A6. Drug Metabolism and Disposition: the Biological Fate of Chemicals. 26: 701-4. PMID 9660853 |
0.305 |
|
| 1998 |
Regal KA, Howald WN, Peter RM, Gartner CA, Kunze KL, Nelson SD. Subnanomolar quantification of caffeine's in vitro metabolites by stable isotope dilution gas chromatography-mass spectrometry. Journal of Chromatography. B, Biomedical Sciences and Applications. 708: 75-85. PMID 9653949 DOI: 10.1016/S0378-4347(97)00656-7 |
0.745 |
|
| 1998 |
Nieusma JL, Claffey DJ, Koop DR, Chen W, Peter RM, Nelson SD, Ruth JA, Ross D. Oxidation of 1,3-butadiene to (R)- and (S)-butadiene monoxide by purified recombinant cytochrome P450 2E1 from rabbit, rat and human. Toxicology Letters. 95: 123-9. PMID 9635416 DOI: 10.1016/S0378-4274(98)00026-5 |
0.348 |
|
| 1998 |
Chen W, Koenigs LL, Thompson SJ, Peter RM, Rettie AE, Trager WF, Nelson SD. Oxidation of acetaminophen to its toxic quinone imine and nontoxic catechol metabolites by baculovirus-expressed and purified human cytochromes P450 2E1 and 2A6 Chemical Research in Toxicology. 11: 295-301. PMID 9548799 DOI: 10.1021/Tx9701687 |
0.696 |
|
| 1997 |
Dietze EC, Schäfer A, Omichinski JG, Nelson SD. Inactivation of glyceraldehyde-3-phosphate dehydrogenase by a reactive metabolite of acetaminophen and mass spectral characterization of an arylated active site peptide Chemical Research in Toxicology. 10: 1097-1103. PMID 9348431 DOI: 10.1021/Tx970090U |
0.426 |
|
| 1997 |
Hoet P, Graf MLM, Bourdi M, Pohl LR, Duray PH, Chen W, Peter RM, Nelson SD, Verlinden N, Lison D. Epidemic of liver disease caused by hydrochlorofluorocarbons used as ozone-sparing substitutes of chlorofluorocarbons Lancet. 350: 556-559. PMID 9284778 DOI: 10.1016/S0140-6736(97)03094-8 |
0.349 |
|
| 1997 |
Sarich T, Kalhorn T, Magee S, al-Sayegh F, Adams S, Slattery J, Goldstein J, Nelson S, Wright J. The effect of omeprazole pretreatment on acetaminophen metabolism in rapid and slow metabolizers of S-mephenytoin. Clinical Pharmacology and Therapeutics. 62: 21-8. PMID 9246016 DOI: 10.1016/S0009-9236(97)90148-X |
0.386 |
|
| 1997 |
Chien JY, Peter RM, Nolan CM, Wartell C, Slattery JT, Nelson SD, Carithers RL, Thummel KE. Influence of polymorphic N-acetyltransferase phenotype on the inhibition and induction of acetaminophen bioactivation with long-term isoniazid. Clinical Pharmacology and Therapeutics. 61: 24-34. PMID 9024171 DOI: 10.1016/S0009-9236(97)90179-X |
0.303 |
|
| 1997 |
Bourdi M, Chen W, Peter RM, Martin JL, Buters JT, Nelson SD, Pohl LR. Human cytochrome P450 2E1 is a major autoantigen associated with halothane hepatitis. Chemical Research in Toxicology. 9: 1159-66. PMID 8902272 DOI: 10.1021/Tx960083Q |
0.377 |
|
| 1996 |
Chen W, Peter RM, McArdle S, Thummel KE, Sigle RO, Nelson SD. Baculovirus expression and purification of human and rat cytochrome P450 2E1. Archives of Biochemistry and Biophysics. 335: 123-30. PMID 8914842 DOI: 10.1006/Abbi.1996.0489 |
0.339 |
|
| 1995 |
Van Beerendonk GJ, Pearson PG, Meijer DK, Mulder GJ, Nelson SD, Meerman JH. Deuterium isotope effect on the metabolism of the flame retardant tris(2,3-dibromopropyl) phosphate in the isolated perfused rat liver. Fundamental and Applied Toxicology : Official Journal of the Society of Toxicology. 28: 111-7. PMID 8566475 DOI: 10.1006/Faat.1995.1152 |
0.383 |
|
| 1995 |
van Beerendonk GJ, Nelson SD, Meerman JH. Metabolism and genotoxicity of the halogenated alkyl compound tris(2,3-dibromopropyl)phosphate. Human & Experimental Toxicology. 13: 861-5. PMID 7718306 DOI: 10.1177/096032719401301208 |
0.339 |
|
| 1995 |
Søderlund EJ, Meyer DJ, Ketterer B, Nelson SD, Dybing E, Holme JA. Metabolism of 1,2-dibromo-3-chloropropane by glutathione S-transferases Chemico-Biological Interactions. 97: 257-272. PMID 7671343 DOI: 10.1016/0009-2797(95)03621-R |
0.377 |
|
| 1995 |
Nelson SD. Mechanisms of the formation and disposition of reactive metabolites that can cause acute liver injury Drug Metabolism Reviews. 27: 147-177. PMID 7641574 DOI: 10.3109/03602539509029821 |
0.341 |
|
| 1994 |
Myers TG, Thummel KE, Kalhorn TF, Nelson SD. Preferred orientations in the binding of 4'-hydroxyacetanilide (acetaminophen) to cytochrome P450 1A1 and 2B1 isoforms as determined by 13C- and 15N-NMR relaxation studies. Journal of Medicinal Chemistry. 37: 860-7. PMID 8145237 DOI: 10.1021/Jm00032A021 |
0.367 |
|
| 1994 |
Låg M, Omichinski JG, Dybing E, Nelson SD, Søderlund EJ. Mutagenic activity of halogenated propanes and propenes: effect of bromine and chlorine positioning Chemico-Biological Interactions. 93: 73-84. PMID 8069951 DOI: 10.1016/0009-2797(94)90087-6 |
0.372 |
|
| 1994 |
van Beerendonk GJ, Nivard MJ, Vogel EW, Nelson SD, Meerman JH. Genotoxicity of the flame retardant tris(2,3-dibromopropyl)phosphate in the rat and Drosophila: effects of deuterium substitution. Carcinogenesis. 15: 1197-202. PMID 8020156 DOI: 10.1093/Carcin/15.6.1197 |
0.308 |
|
| 1994 |
Sigle RO, Titus MA, Harada N, Nelson SD. Baculovirus Mediated High Level Expression of Human Placental Aromatase (CYP19A1) Biochemical and Biophysical Research Communications. 201: 694-700. PMID 8003004 DOI: 10.1006/Bbrc.1994.1756 |
0.308 |
|
| 1994 |
Kouzi SA, McMurtry RJ, Nelson SD. Hepatotoxicity of germander (Teucrium chamaedrys L.) and one of its constituent neoclerodane diterpenes teucrin A in the mouse Chemical Research in Toxicology. 7: 850-856. PMID 7696542 DOI: 10.1021/Tx00042A020 |
0.387 |
|
| 1994 |
Hinson JA, Pumford NR, Nelson SD. The role of metabolic activation in drug toxicity Drug Metabolism Reviews. 26: 395-412. PMID 7521825 DOI: 10.3109/03602539409029805 |
0.36 |
|
| 1993 |
Pearson PG, Omichinski JG, Holme JA, Mcclanahan RH, Brunborg G, Soderlund EJ, Dybing E, Nelson SD. Metabolic Activation of Tris(2,3-dibromopropyl)phosphate to Reactive Intermediates .II. Covalent Binding, Reactive Metabolite Formation, and Differential Metabolite-Specific DNA Damage in Vivo Toxicology and Applied Pharmacology. 118: 196-204. PMID 8441998 DOI: 10.1006/Taap.1993.1025 |
0.337 |
|
| 1993 |
Pearson PG, Omichinski JG, Mcclanahan RH, Soderlund EJ, Dybing E, Nelson SD. Metabolic Activation of Tris(2,3-dibromopropyl)phosphate to Reactive Intermediates. I. Covalent Binding and Reactive Metabolite Formation in Vitro Toxicology and Applied Pharmacology. 118: 186-195. PMID 8441997 DOI: 10.1006/Taap.1993.1024 |
0.374 |
|
| 1993 |
Thummel KE, Lee CA, Kunze KL, Nelson SD, Slattery JT. Oxidation of acetaminophen to N-acetyl-p-aminobenzoquinone imine by human CYP3A4. Biochemical Pharmacology. 45: 1563-9. PMID 8387297 DOI: 10.1016/0006-2952(93)90295-8 |
0.401 |
|
| 1993 |
Zand R, Nelson SD, Slattery JT, Thummel KE, Kalhorn TF, Adams SP, Wright JM. Inhibition and induction of cytochrome P4502E1-catalyzed oxidation by isoniazid in humans. Clinical Pharmacology and Therapeutics. 54: 142-9. PMID 8354023 DOI: 10.1038/Clpt.1993.125 |
0.352 |
|
| 1992 |
Holme JA, Søderlund EJ, Brunborg G, Låg M, Nelson SD, Dybing E. DNA damage and cell death induced by 1,2-dibromo-3-chloropropane (DBCP) and structural analogs in monolayer culture of rat hepatocytes: 3-aminobenzamide inhibits the toxicity of DBCP. Cell Biology and Toxicology. 7: 413-32. PMID 1794113 DOI: 10.1007/Bf00124075 |
0.329 |
|
| 1992 |
Thomassen D, Knebel N, Slattery JT, McClanahan RH, Nelson SD. Reactive intermediates in the oxidation of menthofuran by cytochromes P-450. Chemical Research in Toxicology. 5: 123-30. PMID 1581528 DOI: 10.1021/Tx00025A021 |
0.427 |
|
| 1992 |
Weis M, Morgenstern R, Cotgreave IA, Nelson SD, Moldéus P. N-acetyl-p-benzoquinone imine-induced protein thiol modification in isolated rat hepatocytes. Biochemical Pharmacology. 43: 1493-505. PMID 1567474 DOI: 10.1016/0006-2952(92)90207-Y |
0.354 |
|
| 1992 |
Nelson SD, McClanahan RH, Thomassen D, Gordon WP, Knebel N. Investigations of mechanisms of reactive metabolite formation from (R)-(+)-pulegone. Xenobiotica; the Fate of Foreign Compounds in Biological Systems. 22: 1157-64. PMID 1441606 DOI: 10.3109/00498259209051869 |
0.384 |
|
| 1991 |
Søderlund EJ, Brunborg G, Holme JA, Hongslo JK, Nelson SD, Dybing E. Co-culture systems for assessing the stability and genotoxicity of reactive 1,2-dibromo-3-chloropropane (DBCP) metabolites. Mutagenesis. 6: 25-30. PMID 2038269 DOI: 10.1093/Mutage/6.1.25 |
0.302 |
|
| 1991 |
Holme JA, Hongslo JK, Bjørge C, Nelson SD. Comparative cytotoxic effects of acetaminophen (n-acetyl-p-aminophenol), a non-hepatotoxic regioisomer acetyl-m-aminophenol and their postulated reactive hydroquinone and quinone metabolites in monolayer cultures of mouse hepatocytes Biochemical Pharmacology. 42: 1137-1142. PMID 1872898 DOI: 10.1016/0006-2952(91)90299-K |
0.403 |
|
| 1991 |
Tirmenstein MA, Nelson SD. Hepatotoxicity after 3′-hydroxyacetanilide administration to buthionine sulfoximine pretreated mice Chemical Research in Toxicology. 4: 214-217. PMID 1782350 DOI: 10.1021/Tx00020A014 |
0.303 |
|
| 1991 |
Thomassen D, Pearson PG, Slattery JT, Nelson SD. Partial characterization of biliary metabolites of pulegone by tandem mass spectrometry: Detection of glucuronide, glutathione, and glutathionyl glucuronide conjugates Drug Metabolism and Disposition. 19: 997-1003. PMID 1686249 |
0.301 |
|
| 1990 |
Holme JA, Søderlund EJ, Brunborg G, Hongslo JK, Trygg B, Nelson SD. Comparative genotoxicities of procarbazine and two deuterated analogs in mammalian cells in vitro and in vivo. Mutagenesis. 4: 355-60. PMID 2687629 DOI: 10.1093/Mutage/4.5.355 |
0.326 |
|
| 1990 |
Pearson PG, Soderlund EJ, Dybing E, Nelson SD. Metabolic activation of 1,2-dibromo-3-chloropropane: Evidence for the formation of reactive episulfonium ion intermediates Biochemistry. 29: 4971-4981. PMID 2364069 DOI: 10.1021/Bi00472A030 |
0.385 |
|
| 1990 |
Nelson SD, Pearson PG. Covalent and noncovalent interactions in acute lethal cell injury caused by chemicals Annual Review of Pharmacology and Toxicology. 30: 169-195. PMID 2188567 DOI: 10.1146/Annurev.Pa.30.040190.001125 |
0.335 |
|
| 1990 |
Nicotera P, Hinds TR, Nelson SD, Vincenzi FF. Differential effects of arylating and oxidizing analogs of N-acetyl-p-benzoquinoneimine on red blood cell membrane proteins Archives of Biochemistry and Biophysics. 283: 200-205. PMID 2146923 DOI: 10.1016/0003-9861(90)90631-8 |
0.323 |
|
| 1990 |
Pearson PG, Omichinski JG, Myers TG, Søderlund EJ, Dybing E, Nelson SD. Metabolic activation of 1,2-dibromo-3-chloropropane to mutagenic metabolites: Detection and mechanism of formation of (Z)- And (E)-2-chloro-3-(bromomethyl)oxirane Chemical Research in Toxicology. 3: 458-466. PMID 2133097 DOI: 10.1021/Tx00017A012 |
0.368 |
|
| 1989 |
Bednarski PJ, Nelson SD. Dissociation of 19-hydroxy-, 19-oxo-, and aromatizing-activities in human placental microsomes through the use of suicide substrates to aromatase Journal of Steroid Biochemistry. 32: 309-316. PMID 2921872 DOI: 10.1016/0022-4731(89)90269-0 |
0.323 |
|
| 1989 |
Låg M, Søderlund EJ, Omichinski JG, Nelson SD, Dybing E. Metabolism of selectively methylated and deuterated analogs of 1,2-dibromo-3-chloropropane: Role in organ toxicity and mutagenicity Chemico-Biological Interactions. 69: 33-44. PMID 2914329 DOI: 10.1016/0009-2797(89)90097-5 |
0.382 |
|
| 1989 |
Bednarski PJ, Nelson SD. Interactions of thiol-containing androgens with human placental aromatase Journal of Medicinal Chemistry. 32: 203-213. PMID 2909733 DOI: 10.1021/Jm00121A037 |
0.309 |
|
| 1989 |
Låg M, Søderlund EJ, Brunborg G, Dahl JE, Holme JA, Omichinski JG, Nelson SD, Dybing E. Species differences in testicular necrosis and DNA damage, distribution and metabolism of 1,2-dibromo-3-chloropropane (DBCP) Toxicology. 58: 133-144. PMID 2799822 DOI: 10.1016/0300-483X(89)90003-6 |
0.31 |
|
| 1989 |
Thummel KE, Slattery JT, Nelson SD, Lee CA, Pearson PG. Effect of ethanol on hepatotoxicity of acetaminophen in mice and on reactive metabolite formation by mouse and human liver microsomes. Toxicology and Applied Pharmacology. 100: 391-7. PMID 2781565 DOI: 10.1016/0041-008X(89)90287-1 |
0.325 |
|
| 1989 |
Ramsay RR, Rashed MS, Nelson SD. In vitro effects of acetaminophen metabolites and analogs on the respiration of mouse liver mitochondria Archives of Biochemistry and Biophysics. 273: 449-457. PMID 2774561 DOI: 10.1016/0003-9861(89)90504-3 |
0.356 |
|
| 1989 |
Rashed MS, Nelson SD. Use of thermospray liquid chroamtography-mass spectrometry for characterization of reactive metabolites of 3′-hydroxyacetanilide, an on-hepatotoxic regioisomer of acetaminophen Journal of Chromatography A. 474: 209-222. PMID 2768393 DOI: 10.1016/S0021-9673(01)93916-0 |
0.357 |
|
| 1989 |
Låg M, Omichinski JG, Søderlund EJ, Brunborg G, Holme JA, Dahl JE, Nelson SD, Dybing E. Role of P-450 activity and glutathione levels in 1,2-dibromo-3-chloropropane tissue distribution, renal necrosis and in vivo DNA damage Toxicology. 56: 273-288. PMID 2734806 DOI: 10.1016/0300-483X(89)90091-7 |
0.313 |
|
| 1989 |
Holme JA, Søderlund EJ, Brunborg G, Omichinski JG, Bekkedal K, Trygg B, Nelson SD, Dybing E. Different mechanisms are involved in DNA damage, bacterial mutagenicity and cytotoxicity induced by 1,2-dibromo-3-chloropropane in suspensions of rat liver cells Carcinogenesis. 10: 49-54. PMID 2642751 DOI: 10.1093/Carcin/10.1.49 |
0.36 |
|
| 1989 |
McClanahan RH, Thomassen D, Slattery JT, Nelson SD. Metabolic activation of (R)-(+)-pulegone to a reactive enonal that covalently binds to mouse liver proteins Chemical Research in Toxicology. 2: 349-355. PMID 2519826 DOI: 10.1021/Tx00011A013 |
0.366 |
|
| 1989 |
Rashed MS, Nelson SD. Characterization of glutathione conjugates of reactive metabolites of 3′-hydroxyacetanilide, a nonhepatotoxic positional isomer of acetaminophen Chemical Research in Toxicology. 2: 41-45. PMID 2519230 DOI: 10.1021/Tx00007A007 |
0.446 |
|
| 1988 |
Coles B, Wilson I, Wardman P, Hinson JA, Nelson SD, Ketterer B. The spontaneous and enzymatic reaction of N-acetyl-p-benzoquinonimine with glutathione: a stopped-flow kinetic study. Archives of Biochemistry and Biophysics. 264: 253-60. PMID 3395122 DOI: 10.1016/0003-9861(88)90592-9 |
0.349 |
|
| 1988 |
Holme JA, Hongslo JK, Bjørnstad C, Harvison PJ, Nelson SD. Toxic effects of paracetamol and related structures in V79 Chinese hamster cells. Mutagenesis. 3: 51-6. PMID 3282144 DOI: 10.1093/Mutage/3.1.51 |
0.302 |
|
| 1988 |
Omichinski JG, Soderlund EJ, Dybing E, Pearson PG, Nelson SD. Detection and mechanism of formation of the potent direct-acting mutagen 2-bromoacrolein from 1,2-dibromo-3-chloropropane Toxicology and Applied Pharmacology. 92: 286-294. PMID 3277317 DOI: 10.1016/0041-008X(88)90388-2 |
0.426 |
|
| 1988 |
Harvison PJ, Egan RW, Gale PH, Christian GD, Hill BS, Nelson SD. Acetaminophen and analogs as cosubstrates and inhibitors of prostaglandin H synthase. Chemico-Biological Interactions. 64: 251-66. PMID 3124965 DOI: 10.1016/0009-2797(88)90101-9 |
0.348 |
|
| 1988 |
Harvison PJ, Guengerich FP, Rashed MS, Nelson SD. Cytochrome P-450 isozyme selectivity in the oxidation of acetaminophen Chemical Research in Toxicology. 1: 47-52. PMID 2979711 DOI: 10.1021/Tx00001A009 |
0.383 |
|
| 1988 |
McClanahan RH, Huitric AC, Pearson PG, Desper JC, Nelson SD. Evidence for a cytochrome P-450-catalyzed allylic rearrangement with double-bond topomerization Journal of the American Chemical Society. 110: 1979-1981. DOI: 10.1021/ja00214a060 |
0.569 |
|
| 1988 |
McClanahan RH, Huitric AC, Pearson PG, Desper JC, Nelson SD. Evidence for a cytochrome P-450 catalyzed allylic rearrangement with double bond topomerization Journal of the American Chemical Society. 110: 1979-1981. DOI: 10.1021/Ja00214A060 |
0.606 |
|
| 1987 |
Slattery JT, Wilson JM, Kalhorn TF, Nelson SD. Dose-dependent pharmacokinetics of acetaminophen: evidence of glutathione depletion in humans. Clinical Pharmacology and Therapeutics. 41: 413-8. PMID 3829578 DOI: 10.1038/Clpt.1987.50 |
0.301 |
|
| 1987 |
Omichinski JG, Søderlund EJ, Bausano JA, Dybing E, Nelson SD. Synthesis and mutagenicity of selectively methylated analogs of tris(2,3-dibromopropyl)phosphate and 1,2-dibromo-3-chloropropane Mutagenesis. 2: 287-292. PMID 3325760 DOI: 10.1093/Mutage/2.4.287 |
0.32 |
|
| 1986 |
Kalhorn TF, Thummel KE, Nelson SD, Slattery JT. Analysis of oxidized and reduced pyridine dinucleotides in rat liver by high-performance liquid chromatography. Analytical Biochemistry. 151: 343-7. PMID 4096371 DOI: 10.1016/0003-2697(85)90185-X |
0.304 |
|
| 1986 |
Streeter AJ, Harvison PJ, Nelson SD, Baillie TA. Cross-linking of protein molecules by the reactive metabolite of acetaminophen, N-acetyl-p-benzoquinone imine, and related quinoid compounds. Advances in Experimental Medicine and Biology. 197: 727-37. PMID 3766291 DOI: 10.1007/978-1-4684-5134-4_67 |
0.325 |
|
| 1986 |
Harvison PJ, Forte AJ, Nelson SD. Comparative toxicities and analgesic activities of three monomethylated analogues of acetaminophen Journal of Medicinal Chemistry. 29: 1737-1743. PMID 3746820 DOI: 10.1021/Jm00159A029 |
0.345 |
|
| 1986 |
Pang KS, Terrell JA, Nelson SD, Feuer KF, Clements MJ, Endrenyi L. An enzyme-distributed system for lidocaine metabolism in the perfused rat liver preparation Journal of Pharmacokinetics and Biopharmaceutics. 14: 107-130. PMID 3746635 DOI: 10.1007/Bf01065257 |
0.323 |
|
| 1985 |
Nelson SD. Alteration of drug metabolism by the use of prodrugs Methods in Enzymology. 340-347. PMID 4046854 DOI: 10.1016/S0076-6879(85)12028-8 |
0.323 |
|
| 1985 |
Yost GS, Horstman MG, El Walily AF, Gordon WP, Nelson SD. Procarbazine spermatogenesis toxicity: Deuterium isotope effects point to regioselective metabolism in mice Toxicology and Applied Pharmacology. 80: 316-322. PMID 4024121 DOI: 10.1016/0041-008X(85)90089-4 |
0.314 |
|
| 1985 |
Namkung MJ, Porubek DJ, Nelson SD, Juchau MR. Regulation of aromatic oxidation of estradiol-17β in maternal hepatic, fetal hepatic and placental tissues: Comparative effects of a series of inducing agents Journal of Steroid Biochemistry. 22: 563-567. PMID 3999749 DOI: 10.1016/0022-4731(85)90179-7 |
0.329 |
|
| 1985 |
Søderlund EJ, Dybing E, Holme JA, Hongslo JK, Rivedal E, Sanner T, Nelson SD. Comparative genotoxicity and nephrotoxicity studies of the two halogenated flame retardants tris(1,3-dichloro-2-propyl)phosphate and tris(2,3-dibromopropyl)phosphate. Acta Pharmacologica Et Toxicologica. 56: 20-9. PMID 3883695 DOI: 10.1111/J.1600-0773.1985.Tb01248.X |
0.374 |
|
| 1984 |
Streeter AJ, Dahlin DC, Nelson SD, Baillie TA. The covalent binding of acetaminophen to protein. Evidence for cysteine residues as major sites of arylation in vitro Chemico-Biological Interactions. 48: 349-366. PMID 6713598 DOI: 10.1016/0009-2797(84)90145-5 |
0.367 |
|
| 1984 |
Holme JA, Dahlin DC, Nelson SD, Dybing E. Cytotoxic effects of N-acetyl-p-benzoquinone imine, a common arylating intermediate of paracetamol and N-hydroxyparacetamol Biochemical Pharmacology. 33: 401-406. PMID 6704159 DOI: 10.1016/0006-2952(84)90232-6 |
0.347 |
|
| 1984 |
Holme JA, Søderlund EJ, Hongslo JK, Nelson SD, Dybing E. Comparative genotoxicity studies of the flame retardant tris(2,3-dibromopropyl)phosphate and possible metabolites. Mutation Research. 124: 213-24. PMID 6686285 DOI: 10.1016/0165-1218(83)90192-1 |
0.333 |
|
| 1984 |
Søderujnd EJ, Gordon WP, Nelson SD, Omichinski JG, Dybing E. Metabolism in vitro of tris(2,3-dibromopropyl)- phosphate: Oxidative debromination and bis(2,3- dibromopropyl)phosphate formation as correlates of mutagenicity and covalent protein binding Biochemical Pharmacology. 33: 4017-4023. PMID 6508849 DOI: 10.1016/0006-2952(84)90015-7 |
0.386 |
|
| 1984 |
Dahlin DC, Miwa GT, Lu AY, Nelson SD. N-acetyl-p-benzoquinone imine: a cytochrome P-450-mediated oxidation product of acetaminophen. Proceedings of the National Academy of Sciences of the United States of America. 81: 1327-31. PMID 6424115 DOI: 10.1073/Pnas.81.5.1327 |
0.415 |
|
| 1984 |
Nelson SD, Omichinski JG, Iyer L, Gordon WP, Soderlund EJ, Dybing E. Activation mechanism of Tris(2,3-dibromopropyl)phosphate to the potent mutagen, 2-bromoacrolein Biochemical and Biophysical Research Communications. 121: 213-219. PMID 6375666 DOI: 10.1016/0006-291X(84)90709-5 |
0.332 |
|
| 1984 |
Powis G, Svingen BA, Dahlin DC, Nelson SD. Enzymatic and non-enzymatic reduction of N-acetyl-p-benzoquinone imine and some properties of the N-acetyl-p-benzosemiquinone imine radical Biochemical Pharmacology. 33: 2367-2370. PMID 6087825 DOI: 10.1016/0006-2952(84)90707-X |
0.398 |
|
| 1983 |
Shea JP, Nelson SD, Ford GP. MNDO calculation of kinetic isotope effects in model cytochrome P-450 oxidations Journal of the American Chemical Society. 105: 5451-5454. DOI: 10.1021/Ja00354A044 |
0.332 |
|
| 1982 |
Dahlin DC, Nelson SD. Synthesis, decomposition kinetics, and preliminary toxicological studies of pure N-acetyl-p-benzoquinone imine, a proposed toxic metabolite of acetaminophen Journal of Medicinal Chemistry. 25: 885-886. PMID 7120276 DOI: 10.1002/Chin.198304178 |
0.356 |
|
| 1982 |
SØDERLUND EJ, NELSON SD, VON BAHR C, DYBING E. Species Differences in Kidney Toxicitity and Metabolic Activation of Tris(2,3-dibromopropyl)phosphate* Toxicological Sciences. 2: 187-194. DOI: 10.1016/S0272-0590(82)80045-6 |
0.352 |
|
| 1982 |
Huitric AC, Perry Gordon W, Nelson SD. Preparation of (+)- and (-)-2,3-dibromo-1-propanols Journal of Chemical and Engineering Data. 27: 474-475. DOI: 10.1002/Chin.198302082 |
0.56 |
|
| 1981 |
Söderlund EJ, Nelson SD, Dybing E. In vitro and in vivo covalent binding of the kidney toxicant and carcinogen tris(2,3-dibromopropyl)-phosphate Toxicology. 21: 291-304. PMID 7302950 DOI: 10.1016/0300-483X(81)90144-X |
0.332 |
|
| 1981 |
Nelson SD, Vaishnav Y, Kambara H, Baillie TA. Comparative electron impact, chemical ionization and field desorption mass spectra of some thioether metabolites of acetaminophen Biomedical Mass Spectrometry. 8: 244-251. PMID 7260341 DOI: 10.1002/Bms.1200080604 |
0.31 |
|
| 1981 |
Aune T, Dybing E, Nelson SD, Thorgeirsson SS. Genetic differences in dimethylnitrosamine mutagenicity in vitro associated with mouse hepatic aryl hydrocarbon hydroxylase activity induced by 3-methylcholanthrene Acta Pharmacologica Et Toxicologica. 48: 118-128. PMID 7257823 DOI: 10.1111/J.1600-0773.1981.Tb01597.X |
0.301 |
|
| 1980 |
Nelson SD, Forte AJ, Dahlin DC. Lack of evidence for N-hydroxyacetaminophen as a reactive metabolite of acetaminophen in vitro Biochemical Pharmacology. 29: 1617-1620. PMID 7396994 DOI: 10.1016/0006-2952(80)90622-X |
0.317 |
|
| 1980 |
Aune T, Dybing E, Nelson SD. Mutagenic activation of 2,4-diaminoanisole and 2-aminofluorene by isolated rat liver nuclei and microsomes Chemico-Biological Interactions. 31: 35-49. PMID 6993025 DOI: 10.1016/0009-2797(80)90137-4 |
0.386 |
|
| 1979 |
Dybing E, Aune T, Nelson SD. Metabolic activation of 2,4-diaminoanisole, a hair-dye component-III. Role of cytochrome p-450 metabolism in irreversible binding in vivo Biochemical Pharmacology. 28: 51-55. PMID 758910 DOI: 10.1016/0006-2952(79)90269-7 |
0.352 |
|
| 1979 |
Aune T, Nelson SD, Dybing E. Mutagenicity and irreversible binding of the hepatocarcinogen, 2,4-diaminotoluene Chemico-Biological Interactions. 25: 23-33. PMID 466725 DOI: 10.1016/0009-2797(79)90066-8 |
0.333 |
|
| 1979 |
Soderlund EJ, Nelson SD, Dybing E. Mutagenic activation of tri(2,3-dibromopropyl)phosphate: The role of microsomal oxidative metabolism Acta Pharmacologica Et Toxicologica. 45: 112-121. PMID 40390 DOI: 10.1111/J.1600-0773.1979.Tb02370.X |
0.425 |
|
| 1979 |
Dybing E, Aune T, Nelson SD. Metabolic activation of 2,4-diaminoanisole, a hair-dye component-II. Role of cytochrome P-450 metabolism in irreversible binding in vitro Biochemical Pharmacology. 28: 43-50. PMID 31890 DOI: 10.1016/0006-2952(79)90268-5 |
0.395 |
|
| 1978 |
Nelson SD, Nelson WL, Trager WF. N-hydroxyamide metabolites of lidocaine. Synthesis, characterization, quantitation, and mutagenic potential Journal of Medicinal Chemistry. 21: 721-725. PMID 690997 DOI: 10.1002/Chin.197851153 |
0.571 |
|
| 1977 |
Mitchell JR, McMurtry RJ, Statham CN, Nelson SD. Molecular basis for several drug-induced nephropathies. The American Journal of Medicine. 62: 518-26. PMID 851123 DOI: 10.1016/0002-9343(77)90407-7 |
0.313 |
|
| 1977 |
Nelson SD, Garland WA, Breck GD, Trager WF. Quantification of lidocaine and several metabolites utilizing chemical ionization mass spectrometry and stable isotope labeling Journal of Pharmaceutical Sciences. 66: 1180-1190. PMID 408479 DOI: 10.1002/Jps.2600660834 |
0.602 |
|
| 1977 |
Nelson SD, Pohl LR. Chapter 32. The Use of Stable Isotopes in Medicinal Chemistry Annual Reports in Medicinal Chemistry. 12: 319-330. DOI: 10.1016/S0065-7743(08)61571-7 |
0.334 |
|
| 1976 |
Garland WA, Nelson SD, Sasame HA. Primary and β-secondary deuterium isotope effects in the O-deethylation of phenacetin Biochemical and Biophysical Research Communications. 72: 539-545. PMID 985496 DOI: 10.1016/S0006-291X(76)80074-5 |
0.316 |
|
| 1976 |
Pohl LR, Nelson SD, Porter WR, Trager WF, Fasco MJ, Baker FD, Fenton JW. Warfarin-stereochemical aspects of its metabolism by rat liver microsomes. Biochemical Pharmacology. 25: 2153-62. PMID 971329 |
0.524 |
|
| 1975 |
Nelson SD, Pohl LR, Trager WF. Primary and β-secondary deuterium isotope effects in N-deethylation reactions Journal of Medicinal Chemistry. 18: 1062-1065. PMID 1177251 DOI: 10.1021/Jm00245A003 |
0.531 |
|
| 1975 |
Pohl LR, Nelson SD, Garland WA, Trager WF. The rapid identification of a new metabolite of warfarin via a chemical ionization mass spectrometry ion doublet technique. Biomedical Mass Spectrometry. 2: 23-30. PMID 1131390 DOI: 10.1002/Bms.1200020106 |
0.539 |
|
| 1974 |
Garland WA, Trager WF, Nelson SD. Direct (non-chromatographic) quantification of drugs and their metabolites from human plasma utilizing chemical ionization mass spectrometry and stable isotope labeling: quinidine and lidocaine Biomedical Mass Spectrometry. 1: 124-129. PMID 4433724 DOI: 10.1002/Bms.1200010208 |
0.524 |
|
| 1973 |
Nelson SD, Kollman PA, Trager WF, Rothenberg S. Molecular orbital calculations on suspected intermediates in oxidative amine metabolism Journal of Medicinal Chemistry. 16: 1034-1037. PMID 4745504 DOI: 10.1021/Jm00267A017 |
0.568 |
|
| 1973 |
Nelson SD, Breck GD, Trager WF. In vivo metabolite condensations. Formation of N1-Ethyl-2-methyl-N 3-(2,6-dimethylphenyl)-4-imidazolidinone from the reaction of a metabolite of alcohol with a metabolite of lidocaine Journal of Medicinal Chemistry. 16: 1106-1112. PMID 4201421 DOI: 10.1002/Chin.197404394 |
0.574 |
|
| 1973 |
NELSON SD, KOLLMAN PA, TRAGER WF, ROTHENBERG S. ChemInform Abstract: MOLECULAR ORBITAL CALCULATIONS ON SUSPECTED INTERMEDIATES IN OXIDATIVE AMINE METABOLISM Chemischer Informationsdienst. 4. DOI: 10.1002/Chin.197351188 |
0.57 |
|
| 1972 |
Nelson SD, Kasparian DJ, Trager WF. Reaction of .alpha.-nitro ketones with the ketene-generating compounds, isopropenyl acetate and .alpha.-acetoxystyrene. Synthesis of 3-acetyl- and 3-benzoyl-5-substituted isoxazoles The Journal of Organic Chemistry. 37: 2686-2688. DOI: 10.1021/Jo00982A012 |
0.477 |
|
| 1972 |
NELSON SD, KASPARIAN DJ, TRAGER WF. ChemInform Abstract: DIE RK. VON ALPHA-NITRO-KETONEN MIT KETEN-BILDENDEN REAGENTIEN, ISOPROPENYLACETAT UND ALPHA-ACETOXY-STYROL, SYNTH. VON 3-ACETYL- UND 3-BENZOYL-5-SUBSTITUIERTEN-ISOXAZOLEN Chemischer Informationsdienst. 3: no-no. DOI: 10.1002/Chin.197247334 |
0.452 |
|
| 1969 |
Huitric AC, Nelson SD. Beckmann rearrangement and fission of 2-arylcyclohexanone oxime tosylates. Trapping of carbonium ion intermediates as pyridinium cations The Journal of Organic Chemistry. 34: 1230-1233. DOI: 10.1021/jo01257a010 |
0.524 |
|
| 1969 |
Huitric AC, Nelson SD. Beckmann rearrangement and fission of 2-arylcyclohexanone oxime tosylates. Trapping of carbonium ion intermediates as pyridinium cations Journal of Organic Chemistry. 34: 1230-1233. DOI: 10.1021/Jo01257A010 |
0.565 |
|
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