Jeff Gelles, Ph.D. - Publications

Biochemistry Brandeis University, Waltham, MA, United States 
Single-molecule biochemistry

82 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2021 De Jesus Kim L, Friedman LJ, Looke M, Ramsoomair CK, Gelles J, Bell SP. DDK regulates replication initiation by controlling the multiplicity of Cdc45-GINS binding to Mcm2-7. Elife. 10. PMID 33616038 DOI: 10.7554/eLife.65471  0.56
2021 Shekhar S, Hoeprich GJ, Gelles J, Goode BL. Twinfilin bypasses assembly conditions and actin filament aging to drive barbed end depolymerization. The Journal of Cell Biology. 220. PMID 33226418 DOI: 10.1083/jcb.202006022  0.72
2020 Rosen GA, Baek I, Friedman LJ, Joo YJ, Buratowski S, Gelles J. Dynamics of RNA polymerase II and elongation factor Spt4/5 recruitment during activator-dependent transcription. Proceedings of the National Academy of Sciences of the United States of America. PMID 33293419 DOI: 10.1073/pnas.2011224117  0.56
2020 Harden TT, Herlambang KS, Chamberlain M, Lalanne JB, Wells CD, Li GW, Landick R, Hochschild A, Kondev J, Gelles J. Alternative transcription cycle for bacterial RNA polymerase. Nature Communications. 11: 448. PMID 31974358 DOI: 10.1038/S41467-019-14208-9  0.6
2019 Shekhar S, Chung J, Kondev J, Gelles J, Goode BL. Synergy between Cyclase-associated protein and Cofilin accelerates actin filament depolymerization by two orders of magnitude. Nature Communications. 10: 5319. PMID 31757952 DOI: 10.1038/S41467-019-13268-1  0.72
2019 Champasa K, Blank C, Friedman LJ, Gelles J, Bell SP. A conserved Mcm4 motif is required for Mcm2-7 double-hexamer formation and origin DNA unwinding. Elife. 8. PMID 31385807 DOI: 10.7554/Elife.45538  0.56
2019 Huang B, Friedman LJ, Sun M, Gelles J, Street TO. Conformational Cycling within the Closed State of Grp94, an Hsp90-Family Chaperone. Journal of Molecular Biology. PMID 31202885 DOI: 10.1016/J.Jmb.2019.06.004  0.56
2019 Stumper SK, Ravi H, Friedman LJ, Mooney RA, Corrêa IR, Gershenson A, Landick R, Gelles J. Delayed inhibition mechanism for secondary channel factor regulation of ribosomal RNA transcription. Elife. 8. PMID 30720429 DOI: 10.7554/Elife.40576  0.56
2018 Braun JE, Friedman LJ, Gelles J, Moore MJ. Synergistic assembly of human pre-spliceosomes across introns and exons. Elife. 7. PMID 29932423 DOI: 10.7554/Elife.37751  0.72
2017 Ticau S, Friedman LJ, Champasa K, Corrêa IR, Gelles J, Bell SP. Mechanism and timing of Mcm2-7 ring closure during DNA replication origin licensing. Nature Structural & Molecular Biology. PMID 28191892 DOI: 10.1038/Nsmb.3375  0.56
2017 Tetone LE, Friedman LJ, Osborne ML, Ravi H, Kyzer S, Stumper SK, Mooney RA, Landick R, Gelles J. Dynamics of GreB-RNA polymerase interaction allow a proofreading accessory protein to patrol for transcription complexes needing rescue. Proceedings of the National Academy of Sciences of the United States of America. PMID 28137878 DOI: 10.1073/Pnas.1616525114  0.56
2016 Chadda R, Krishnamani V, Mersch K, Wong J, Brimberry M, Chadda A, Kolmakova-Partensky L, Friedman LJ, Gelles J, Robertson JL. The dimerization equilibrium of a ClC Cl(-)/H(+) antiporter in lipid bilayers. Elife. 5. PMID 27484630 DOI: 10.7554/Elife.17438  0.56
2016 Hoskins AA, Rodgers ML, Friedman LJ, Gelles J, Moore MJ. Single molecule analysis reveals reversible and irreversible steps during spliceosome activation. Elife. 5. PMID 27244240 DOI: 10.7554/Elife.14166  0.72
2016 Harden TT, Wells CD, Friedman LJ, Landick R, Hochschild A, Kondev J, Gelles J. Bacterial RNA polymerase can retain σ70 throughout transcription. Proceedings of the National Academy of Sciences of the United States of America. PMID 26733675 DOI: 10.1073/Pnas.1513899113  1
2015 Bombardier JP, Eskin JA, Jaiswal R, Corrêa IR, Xu MQ, Goode BL, Gelles J. Single-molecule visualization of a formin-capping protein 'decision complex' at the actin filament barbed end. Nature Communications. 6: 8707. PMID 26566078 DOI: 10.1038/Ncomms9707  0.72
2015 Friedman LJ, Gelles J. Multi-wavelength single-molecule fluorescence analysis of transcription mechanisms. Methods (San Diego, Calif.). PMID 26032816 DOI: 10.1016/J.Ymeth.2015.05.026  1
2015 Jansen S, Collins A, Chin SM, Ydenberg CA, Gelles J, Goode BL. Single-molecule imaging of a three-component ordered actin disassembly mechanism. Nature Communications. 6: 7202. PMID 25995115 DOI: 10.1038/Ncomms8202  1
2015 Ticau S, Friedman LJ, Ivica NA, Gelles J, Bell SP. Single-molecule studies of origin licensing reveal mechanisms ensuring bidirectional helicase loading. Cell. 161: 513-25. PMID 25892223 DOI: 10.1016/J.Cell.2015.03.012  1
2014 Paramanathan T, Reeves D, Friedman LJ, Kondev J, Gelles J. A general mechanism for competitor-induced dissociation of molecular complexes. Nature Communications. 5: 5207. PMID 25342513 DOI: 10.1038/Ncomms6207  1
2014 Smith BA, Gelles J, Goode BL. Single-molecule studies of actin assembly and disassembly factors. Methods in Enzymology. 540: 95-117. PMID 24630103 DOI: 10.1016/B978-0-12-397924-7.00006-6  1
2014 Wang TY, Friedman LJ, Gelles J, Min W, Hoskins AA, Cornish VW. The covalent trimethoprim chemical tag facilitates single molecule imaging with organic fluorophores. Biophysical Journal. 106: 272-8. PMID 24411259 DOI: 10.1016/J.Bpj.2013.11.4488  1
2013 Shcherbakova I, Hoskins AA, Friedman LJ, Serebrov V, Corrêa IR, Xu MQ, Gelles J, Moore MJ. Alternative spliceosome assembly pathways revealed by single-molecule fluorescence microscopy. Cell Reports. 5: 151-65. PMID 24075986 DOI: 10.1016/J.Celrep.2013.08.026  0.72
2013 Smith BA, Padrick SB, Doolittle LK, Daugherty-Clarke K, Corrêa IR, Xu MQ, Goode BL, Rosen MK, Gelles J. Three-color single molecule imaging shows WASP detachment from Arp2/3 complex triggers actin filament branch formation. Elife. 2: e01008. PMID 24015360 DOI: 10.7554/Elife.01008  1
2013 Friedman LJ, Mumm JP, Gelles J. RNA polymerase approaches its promoter without long-range sliding along DNA. Proceedings of the National Academy of Sciences of the United States of America. 110: 9740-5. PMID 23720315 DOI: 10.1073/Pnas.1300221110  1
2013 Crawford DJ, Hoskins AA, Friedman LJ, Gelles J, Moore MJ. Single-molecule colocalization FRET evidence that spliceosome activation precedes stable approach of 5' splice site and branch site. Proceedings of the National Academy of Sciences of the United States of America. 110: 6783-8. PMID 23569281 DOI: 10.1073/Pnas.1219305110  0.72
2013 Smith BA, Daugherty-Clarke K, Goode BL, Gelles J. Pathway of actin filament branch formation by Arp2/3 complex revealed by single-molecule imaging. Proceedings of the National Academy of Sciences of the United States of America. 110: 1285-90. PMID 23292935 DOI: 10.1073/Pnas.1211164110  1
2012 Garcia HG, Sanchez A, Boedicker JQ, Osborne M, Gelles J, Kondev J, Phillips R. Operator sequence alters gene expression independently of transcription factor occupancy in bacteria. Cell Reports. 2: 150-61. PMID 22840405 DOI: 10.1016/J.Celrep.2012.06.004  1
2012 Breitsprecher D, Jaiswal R, Bombardier JP, Gould CJ, Gelles J, Goode BL. Rocket launcher mechanism of collaborative actin assembly defined by single-molecule imaging. Science (New York, N.Y.). 336: 1164-8. PMID 22654058 DOI: 10.1126/Science.1218062  1
2012 Friedman LJ, Gelles J. Mechanism of transcription initiation at an activator-dependent promoter defined by single-molecule observation. Cell. 148: 679-89. PMID 22341441 DOI: 10.1016/J.Cell.2012.01.018  1
2012 Hoskins AA, Friedman LJ, Crawford DJ, Anderson EJ, Shcherbakova I, Cornish VW, Gelles J, Moore MJ. Into the CoSMoS: Single Molecule Analysis of Spliceosome Assembly and Activation Biophysical Journal. 102: 610a. DOI: 10.1016/J.Bpj.2011.11.3324  0.72
2012 Hoskins A, Friedman L, Correa I, Xu M, Cornish VW, Gelles J, Moore MJ. Turning on the Spliceosome Biophysical Journal. 102: 602a. DOI: 10.1016/J.Bpj.2011.11.3278  0.72
2011 Hoskins AA, Gelles J, Moore MJ. New insights into the spliceosome by single molecule fluorescence microscopy. Current Opinion in Chemical Biology. 15: 864-70. PMID 22057211 DOI: 10.1016/J.Cbpa.2011.10.010  0.72
2011 Ydenberg CA, Smith BA, Breitsprecher D, Gelles J, Goode BL. Cease-fire at the leading edge: new perspectives on actin filament branching, debranching, and cross-linking. Cytoskeleton (Hoboken, N.J.). 68: 596-602. PMID 22002930 DOI: 10.1002/Cm.20543  1
2011 Sanchez A, Osborne ML, Friedman LJ, Kondev J, Gelles J. Mechanism of transcriptional repression at a bacterial promoter by analysis of single molecules. The Embo Journal. 30: 3940-6. PMID 21829165 DOI: 10.1038/Emboj.2011.273  1
2011 Hoskins AA, Friedman LJ, Gallagher SS, Crawford DJ, Anderson EG, Wombacher R, Ramirez N, Cornish VW, Gelles J, Moore MJ. Ordered and dynamic assembly of single spliceosomes. Science (New York, N.Y.). 331: 1289-95. PMID 21393538 DOI: 10.1126/Science.1198830  0.72
2011 Crawford DJ, Friedman LJ, Hoskins AA, Gelles J, Moore MJ. Direct Observation of pre-mRNA Arrangements During Spliceosome Assembly Using Single Molecule FRET Biophysical Journal. 100: 233a. DOI: 10.1016/J.Bpj.2010.12.1488  0.72
2011 Hoskins A, Friedman L, Gallagher SS, Crawford DJ, Anderson EG, Wombacher R, Ramirez N, Cornish VW, Gelles J, Moore MJ. Dynamic and Ordered Assembly of Single Spliceosomes Biophysical Journal. 100: 233a. DOI: 10.1016/J.Bpj.2010.12.1487  0.72
2010 Gandhi M, Smith BA, Bovellan M, Paavilainen V, Daugherty-Clarke K, Gelles J, Lappalainen P, Goode BL. GMF is a cofilin homolog that binds Arp2/3 complex to stimulate filament debranching and inhibit actin nucleation. Current Biology : Cb. 20: 861-7. PMID 20362448 DOI: 10.1016/J.Cub.2010.03.026  1
2008 Wong OK, Guthold M, Erie DA, Gelles J. Interconvertible lac repressor-DNA loops revealed by single-molecule experiments. Plos Biology. 6: e232. PMID 18828671 DOI: 10.1371/Journal.Pbio.0060232  1
2008 Thoresen T, Gelles J. Processive movement by a kinesin heterodimer with an inactivating mutation in one head. Biochemistry. 47: 9514-21. PMID 18702529 DOI: 10.1021/Bi800747E  1
2008 Crawford DJ, Hoskins AA, Friedman LJ, Gelles J, Moore MJ. Visualizing the splicing of single pre-mRNA molecules in whole cell extract. Rna (New York, N.Y.). 14: 170-9. PMID 18025254 DOI: 10.1261/Rna.794808  0.72
2007 Subramanian R, Gelles J. Two distinct modes of processive kinesin movement in mixtures of ATP and AMP-PNP. The Journal of General Physiology. 130: 445-55. PMID 17968024 DOI: 10.1083/Jcb1794Oia11  1
2006 Mumm JP, Landy A, Gelles J. Viewing single lambda site-specific recombination events from start to finish. The Embo Journal. 25: 4586-95. PMID 16977316 DOI: 10.1038/Sj.Emboj.7601325  1
2006 Dalal RV, Larson MH, Neuman KC, Gelles J, Landick R, Block SM. Pulling on the nascent RNA during transcription does not alter kinetics of elongation or ubiquitous pausing. Molecular Cell. 23: 231-9. PMID 16857589 DOI: 10.1016/J.Molcel.2006.06.023  1
2006 Friedman LJ, Chung J, Gelles J. Viewing dynamic assembly of molecular complexes by multi-wavelength single-molecule fluorescence. Biophysical Journal. 91: 1023-31. PMID 16698779 DOI: 10.1529/Biophysj.106.084004  1
2004 Yang W, Gelles J, Musser SM. Imaging of single-molecule translocation through nuclear pore complexes. Proceedings of the National Academy of Sciences of the United States of America. 101: 12887-92. PMID 15306682 DOI: 10.1073/Pnas.0403675101  1
2004 Perkins TT, Li HW, Dalal RV, Gelles J, Block SM. Forward and reverse motion of single RecBCD molecules on DNA. Biophysical Journal. 86: 1640-8. PMID 14990491 DOI: 10.1016/S0006-3495(04)74232-0  1
2004 Toli?-Nørrelykke SF, Engh AM, Landick R, Gelles J. Diversity in the rates of transcript elongation by single RNA polymerase molecules. The Journal of Biological Chemistry. 279: 3292-9. PMID 14604986 DOI: 10.1074/Jbc.M310290200  1
2003 Neuman KC, Abbondanzieri EA, Landick R, Gelles J, Block SM. Ubiquitous transcriptional pausing is independent of RNA polymerase backtracking. Cell. 115: 437-47. PMID 14622598 DOI: 10.1016/S0092-8674(03)00845-6  1
2002 Hua W, Chung J, Gelles J. Distinguishing inchworm and hand-over-hand processive kinesin movement by neck rotation measurements. Science (New York, N.Y.). 295: 844-8. PMID 11823639 DOI: 10.1126/Science.1063089  1
2001 Dohoney KM, Gelles J. Chi-sequence recognition and DNA translocation by single RecBCD helicase/nuclease molecules. Nature. 409: 370-4. PMID 11201749 DOI: 10.1038/35053124  1
1999 Yin H, Artsimovitch I, Landick R, Gelles J. Nonequilibrium mechanism of transcription termination from observations of single RNA polymerase molecules. Proceedings of the National Academy of Sciences of the United States of America. 96: 13124-9. PMID 10557284 DOI: 10.1073/Pnas.96.23.13124  1
1998 Wang MD, Schnitzer MJ, Yin H, Landick R, Gelles J, Block SM. Force and velocity measured for single molecules of RNA polymerase. Science (New York, N.Y.). 282: 902-7. PMID 9794753 DOI: 10.1126/Science.282.5390.902  1
1998 Gelles J, Landick R. RNA polymerase as a molecular motor. Cell. 93: 13-6. PMID 9546386 DOI: 10.1016/S0092-8674(00)81140-X  1
1998 Young EC, Mahtani HK, Gelles J. One-headed kinesin derivatives move by a nonprocessive, low-duty ratio mechanism unlike that of two-headed kinesin. Biochemistry. 37: 3467-79. PMID 9521668 DOI: 10.1021/Bi972172N  1
1998 Vugmeyster Y, Berliner E, Gelles J. Release of isolated single kinesin molecules from microtubules. Biochemistry. 37: 747-57. PMID 9425099 DOI: 10.1021/Bi971534O  1
1997 Hua W, Young EC, Fleming ML, Gelles J. Coupling of kinesin steps to ATP hydrolysis. Nature. 388: 390-3. PMID 9237758 DOI: 10.1038/41118  1
1997 Wang MD, Yin H, Landick R, Gelles J, Block SM. Stretching DNA with optical tweezers. Biophysical Journal. 72: 1335-46. PMID 9138579 DOI: 10.1016/S0006-3495(97)78780-0  1
1995 Young EC, Berliner E, Mahtani HK, Perez-Ramirez B, Gelles J. Subunit interactions in dimeric kinesin heavy chain derivatives that lack the kinesin rod. The Journal of Biological Chemistry. 270: 3926-31. PMID 7876139 DOI: 10.1074/Jbc.270.8.3926  1
1995 Berliner E, Young EC, Anderson K, Mahtani HK, Gelles J. Failure of a single-headed kinesin to track parallel to microtubule protofilaments. Nature. 373: 718-21. PMID 7854458 DOI: 10.1038/373718A0  1
1995 Finzi L, Gelles J. Measurement of lactose repressor-mediated loop formation and breakdown in single DNA molecules. Science (New York, N.Y.). 267: 378-80. PMID 7824935 DOI: 10.1126/Science.7824935  1
1995 Gelles J, Yin H, Finzi L, Wong OK, Landick R. Single-molecule kinetic studies on DNA transcription and transcriptional regulation. Biophysical Journal. 68: 73S. PMID 7787108  1
1995 Ming Ya Jiang, Sheetz MP, Gelles J, Johnson K. Cargo-activated ATpase activity of kinesin Biophysical Journal. 68: 283s-285s. PMID 7787091  1
1995 Gelles J, Berliner E, Young EC, Mahtani HK, Perez-Ramirez B, Anderson K. Structural and functional features of one- and two-headed biotinated kinesin derivatives. Biophysical Journal. 68: 276S-281S; discussio. PMID 7787090  1
1995 Yin H, Wang MD, Svoboda K, Landick R, Block SM, Gelles J. Transcription against an applied force. Science (New York, N.Y.). 270: 1653-7. PMID 7502073 DOI: 10.1126/Science.270.5242.1653  1
1995 Block SM, Svoboda K, Howard J, Guilford B, Johnson K, Goldman Y, Oster G, Gelles J, Hackney D. Analysis of high resolution recordings of motor movement Biophysical Journal. 68: 230s-241s.  1
1994 Berliner E, Mahtani HK, Karki S, Chu LF, Cronan JE, Gelles J. Microtubule movement by a biotinated kinesin bound to streptavidin-coated surface. The Journal of Biological Chemistry. 269: 8610-5. PMID 8132586  1
1994 Yin H, Landick R, Gelles J. Tethered particle motion method for studying transcript elongation by a single RNA polymerase molecule. Biophysical Journal. 67: 2468-78. PMID 7696485 DOI: 10.1016/S0006-3495(94)80735-0  1
1991 Schafer DA, Gelles J, Sheetz MP, Landick R. Transcription by single molecules of RNA polymerase observed by light microscopy. Nature. 352: 444-8. PMID 1861724 DOI: 10.1038/352444A0  1
1991 Kuo SC, Gelles J, Steuer E, Sheetz MP. A model for kinesin movement from nanometer-level movements of kinesin and cytoplasmic dynein and force measurements. Journal of Cell Science. Supplement. 14: 135-8. PMID 1832166 DOI: 10.1242/Jcs.1991.Supplement_14.27  1
1989 Sheetz MP, Gelles J, Steuer ER, Schnapp BJ, Dubinska J, Qian H, Elson E. Nanometer measurements of motor protein and membrane glycoprotein movements Proceedings of Spie - the International Society For Optical Engineering. 1161: 264-265. DOI: 10.1117/12.962707  1
1988 Schnapp BJ, Gelles J, Sheetz MP. Nanometer-scale measurements using video light microscopy. Cell Motility and the Cytoskeleton. 10: 47-53. PMID 3141071 DOI: 10.1002/Cm.970100109  1
1988 Gelles J, Schnapp BJ, Sheetz MP. Tracking kinesin-driven movements with nanometre-scale precision. Nature. 331: 450-3. PMID 3123999 DOI: 10.1038/331450A0  1
1988 Chan SI, Li PM, Nilsson T, Gelles J, Blair DF, Martin CT. A proposal for the site and mechanism of redox-linked proton translocation in cytochrome c oxidase. Progress in Clinical and Biological Research. 274: 731-47. PMID 2841687  1
1988 Nilsson T, Gelles J, Li PM, Chan SI. Chemical modification of the CuA site affects the proton pumping activity of cytochrome c oxidase. Biochemistry. 27: 296-301. PMID 2831955 DOI: 10.1021/Bi00401A045  1
1987 Li PM, Gelles J, Chan SI, Sullivan RJ, Scott RA. Extended X-ray absorption fine structure of copper in CuA-depleted, p-(hydroxymercuri)benzoate-modified, and native cytochrome c oxidase. Biochemistry. 26: 2091-5. PMID 3040080 DOI: 10.1021/Bi00382A005  1
1986 Gelles J, Blair DF, Chan SI. The proton-pumping site of cytochrome c oxidase: a model of its structure and mechanism. Biochimica Et Biophysica Acta. 853: 205-36. PMID 3040090 DOI: 10.1016/0304-4173(87)90002-4  1
1986 Blair DF, Gelles J, Chan SI. Redox-linked proton translocation in cytochrome oxidase: the importance of gating electron flow. The effects of slip in a model transducer. Biophysical Journal. 50: 713-33. PMID 3022836 DOI: 10.1016/S0006-3495(86)83511-1  1
1985 Gelles J, Chan SI. Chemical modification of the CuA center in cytochrome c oxidase by sodium p-(hydroxymercuri)benzoate. Biochemistry. 24: 3963-72. PMID 2996587 DOI: 10.1021/Bi00336A025  1
1982 Blair DF, Martin CT, Gelles J, Wang H, Brudvig GW, Stevens TH, Chan SI. METAL CENTERS OF CYTOCHROME c OXIDASE: STRUCTURES AND INTERACTIONS Chemica Scripta. 21: 43-53.  1
1978 Gelles J, Klapper MH. Pseudo-dynamic contact surface areas: estimation of apolar bonding. Biochimica Et Biophysica Acta. 533: 465-77. PMID 647019 DOI: 10.1016/0005-2795(78)90392-6  1
1978 Cantley LC, Gelles J, Josephson L. Reaction of (Na-K)ATPase with 7-chloro-4-nitrobenzo-2-oxa-1,3-diazole: evidence for an essential tyrosine at the active site. Biochemistry. 17: 418-25. PMID 145873 DOI: 10.1021/Bi00596A006  1
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