K. Dane Wittrup - Publications

Affiliations: 
1989-1999 Chemical Engineering University of Illinois, Urbana-Champaign, Urbana-Champaign, IL 
 1999- Chemical Engineering and Biological Engineering Massachusetts Institute of Technology, Cambridge, MA, United States 
Website:
https://be.mit.edu/directory/k-dane-wittrup

135 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2017 Kwan BH, Zhu EF, Tzeng A, Sugito HR, Eltahir AA, Ma B, Delaney MK, Murphy PA, Kauke MJ, Angelini A, Momin N, Mehta NK, Maragh AM, Hynes RO, Dranoff G, ... ... Wittrup KD, et al. Integrin-targeted cancer immunotherapy elicits protective adaptive immune responses. The Journal of Experimental Medicine. PMID 28473400 DOI: 10.1084/jem.20160831  0.36
2016 Moynihan KD, Opel CF, Szeto GL, Tzeng A, Zhu EF, Engreitz JM, Williams RT, Rakhra K, Zhang MH, Rothschilds AM, Kumari S, Kelly RL, Kwan BH, Abraham W, Hu K, ... ... Wittrup KD, et al. Eradication of large established tumors in mice by combination immunotherapy that engages innate and adaptive immune responses. Nature Medicine. PMID 27775706 DOI: 10.1038/nm.4200  0.48
2016 Kelly RL, Yu Y, Sun T, Caffry I, Lynaugh H, Brown M, Jain T, Xu Y, Wittrup KD. Target-independent variable region mediated effects on antibody clearance can be FcRn independent. Mabs. 0. PMID 27610650 DOI: 10.1080/19420862.2016.1208330  0.96
2016 de Picciotto S, Dickson PM, Traxlmayr MW, Marques BS, Socher E, Zhao S, Cheung S, Kiefer J, Wand AJ, Griffith LG, Imperiali B, Wittrup KD. Design principles for reagentless biosensors: Specific fluorophore/analyte binding and minimization of fluorophore/scaffold interactions. Journal of Molecular Biology. PMID 27448945 DOI: 10.1016/j.jmb.2016.07.004  0.96
2016 Maass KF, Kulkarni C, Betts AM, Wittrup KD. Determination of Cellular Processing Rates for a Trastuzumab-Maytansinoid Antibody-Drug Conjugate (ADC) Highlights Key Parameters for ADC Design. The Aaps Journal. PMID 26912181 DOI: 10.1208/s12248-016-9892-3  0.96
2015 Maass KF, Kulkarni C, Quadir MA, Hammond PT, Betts AM, Wittrup KD. A Flow Cytometric Clonogenic Assay Reveals the Single-Cell Potency of Doxorubicin. Journal of Pharmaceutical Sciences. PMID 26344409 DOI: 10.1002/jps.24631  0.96
2015 Yang NJ, Liu DV, Sklaviadis D, Gui DY, Vander Heiden MG, Wittrup KD. Antibody-mediated neutralization of perfringolysin o for intracellular protein delivery. Molecular Pharmaceutics. 12: 1992-2000. PMID 25881713 DOI: 10.1021/mp500797n  0.96
2015 Zhu EF, Gai SA, Opel CF, Kwan BH, Surana R, Mihm MC, Kauke MJ, Moynihan KD, Angelini A, Williams RT, Stephan MT, Kim JS, Yaffe MB, Irvine DJ, Weiner LM, ... ... Wittrup KD, et al. Synergistic innate and adaptive immune response to combination immunotherapy with anti-tumor antigen antibodies and extended serum half-life IL-2. Cancer Cell. 27: 489-501. PMID 25873172 DOI: 10.1016/j.ccell.2015.03.004  0.96
2015 Tzeng A, Kwan BH, Opel CF, Navaratna T, Wittrup KD. Antigen specificity can be irrelevant to immunocytokine efficacy and biodistribution. Proceedings of the National Academy of Sciences of the United States of America. 112: 3320-5. PMID 25733854 DOI: 10.1073/pnas.1416159112  0.96
2013 Yao X, Labelle M, Lamb CR, Dugan JM, Williamson CA, Spencer DR, Christ KR, Keating RO, Lee WD, Paradis GA, Begum S, Hynes RO, Wittrup KD. Determination of 35 cell surface antigen levels in malignant pleural effusions identifies CD24 as a marker of disseminated tumor cells. International Journal of Cancer. Journal International Du Cancer. 133: 2925-33. PMID 23775727 DOI: 10.1002/ijc.28312  0.96
2012 Wittrup KD, Thurber GM, Schmidt MM, Rhoden JJ. Practical theoretic guidance for the design of tumor-targeting agents. Methods in Enzymology. 503: 255-68. PMID 22230572 DOI: 10.1016/B978-0-12-396962-0.00010-0  0.96
2012 Hackel BJ, Neil JR, White FM, Wittrup KD. Epidermal growth factor receptor downregulation by small heterodimeric binding proteins. Protein Engineering, Design & Selection : Peds. 25: 47-57. PMID 22160867 DOI: 10.1093/protein/gzr056  0.96
2012 Rhoden JJ, Wittrup KD. Dose dependence of intratumoral perivascular distribution of monoclonal antibodies. Journal of Pharmaceutical Sciences. 101: 860-7. PMID 22057714 DOI: 10.1002/jps.22801  0.96
2011 Boersma YL, Chao G, Steiner D, Wittrup KD, Plückthun A. Bispecific designed ankyrin repeat proteins (DARPins) targeting epidermal growth factor receptor inhibit A431 cell proliferation and receptor recycling. The Journal of Biological Chemistry. 286: 41273-85. PMID 21979953 DOI: 10.1074/jbc.M111.293266  0.96
2011 Schiefner A, Chatwell L, Körner J, Neumaier I, Colby DW, Volkmer R, Wittrup KD, Skerra A. A disulfide-free single-domain V(L) intrabody with blocking activity towards huntingtin reveals a novel mode of epitope recognition. Journal of Molecular Biology. 414: 337-55. PMID 21968397 DOI: 10.1016/j.jmb.2011.09.034  0.96
2011 Ackerman ME, Lai JI, Pastan I, Wittrup KD. Exploiting bias in a non-immune human antibody library to predict antigenicity. Protein Engineering, Design & Selection : Peds. 24: 845-53. PMID 21908549 DOI: 10.1093/protein/gzr046  0.96
2011 Orcutt KD, Slusarczyk AL, Cieslewicz M, Ruiz-Yi B, Bhushan KR, Frangioni JV, Wittrup KD. Engineering an antibody with picomolar affinity to DOTA chelates of multiple radionuclides for pretargeted radioimmunotherapy and imaging. Nuclear Medicine and Biology. 38: 223-33. PMID 21315278 DOI: 10.1016/j.nucmedbio.2010.08.013  0.96
2011 Pirie CM, Hackel BJ, Rosenblum MG, Wittrup KD. Convergent potency of internalized gelonin immunotoxins across varied cell lines, antigens, and targeting moieties. The Journal of Biological Chemistry. 286: 4165-72. PMID 21138845 DOI: 10.1074/jbc.M110.186973  0.96
2011 Orcutt KD, Nasr KA, Whitehead DG, Frangioni JV, Wittrup KD. Biodistribution and clearance of small molecule hapten chelates for pretargeted radioimmunotherapy. Molecular Imaging and Biology : Mib : the Official Publication of the Academy of Molecular Imaging. 13: 215-21. PMID 20533093 DOI: 10.1007/s11307-010-0353-6  0.96
2010 Spangler JB, Neil JR, Abramovitch S, Yarden Y, White FM, Lauffenburger DA, Wittrup KD. Combination antibody treatment down-regulates epidermal growth factor receptor by inhibiting endosomal recycling. Proceedings of the National Academy of Sciences of the United States of America. 107: 13252-7. PMID 20616078 DOI: 10.1073/pnas.0913476107  0.96
2010 Hackel BJ, Ackerman ME, Howland SW, Wittrup KD. Stability and CDR composition biases enrich binder functionality landscapes. Journal of Molecular Biology. 401: 84-96. PMID 20540948 DOI: 10.1016/j.jmb.2010.06.004  0.96
2010 Higham EM, Shen CH, Wittrup KD, Chen J. Cutting edge: delay and reversal of T cell tolerance by intratumoral injection of antigen-loaded dendritic cells in an autochthonous tumor model. Journal of Immunology (Baltimore, Md. : 1950). 184: 5954-8. PMID 20427765 DOI: 10.4049/jimmunol.1000265  0.96
2010 Hackel BJ, Wittrup KD. The full amino acid repertoire is superior to serine/tyrosine for selection of high affinity immunoglobulin G binders from the fibronectin scaffold. Protein Engineering, Design & Selection : Peds. 23: 211-9. PMID 20067921 DOI: 10.1093/protein/gzp083  0.96
2010 Orcutt KD, Ackerman ME, Cieslewicz M, Quiroz E, Slusarczyk AL, Frangioni JV, Wittrup KD. A modular IgG-scFv bispecific antibody topology. Protein Engineering, Design & Selection : Peds. 23: 221-8. PMID 20019028 DOI: 10.1093/protein/gzp077  0.96
2009 Schmidt MM, Wittrup KD. A modeling analysis of the effects of molecular size and binding affinity on tumor targeting. Molecular Cancer Therapeutics. 8: 2861-71. PMID 19825804 DOI: 10.1158/1535-7163.MCT-09-0195  0.96
2009 Liu DV, Maier LM, Hafler DA, Wittrup KD. Engineered interleukin-2 antagonists for the inhibition of regulatory T cells. Journal of Immunotherapy (Hagerstown, Md. : 1997). 32: 887-94. PMID 19816193 DOI: 10.1097/CJI.0b013e3181b528da  0.96
2009 Tasumi S, Velikovsky CA, Xu G, Gai SA, Wittrup KD, Flajnik MF, Mariuzza RA, Pancer Z. High-affinity lamprey VLRA and VLRB monoclonal antibodies. Proceedings of the National Academy of Sciences of the United States of America. 106: 12891-6. PMID 19625627 DOI: 10.1073/pnas.0904443106  0.96
2009 Rakestraw JA, Sazinsky SL, Piatesi A, Antipov E, Wittrup KD. Directed evolution of a secretory leader for the improved expression of heterologous proteins and full-length antibodies in Saccharomyces cerevisiae. Biotechnology and Bioengineering. 103: 1192-201. PMID 19459139 DOI: 10.1002/bit.22338  0.96
2009 Ackerman M, Levary D, Tobon G, Hackel B, Orcutt KD, Wittrup KD. Highly avid magnetic bead capture: an efficient selection method for de novo protein engineering utilizing yeast surface display. Biotechnology Progress. 25: 774-83. PMID 19363813 DOI: 10.1002/btpr.174  0.96
2009 Maier LM, Anderson DE, Severson CA, Baecher-Allan C, Healy B, Liu DV, Wittrup KD, De Jager PL, Hafler DA. Soluble IL-2RA levels in multiple sclerosis subjects and the effect of soluble IL-2RA on immune responses. Journal of Immunology (Baltimore, Md. : 1950). 182: 1541-7. PMID 19155502  0.96
2008 Sazinsky SL, Ott RG, Silver NW, Tidor B, Ravetch JV, Wittrup KD. Aglycosylated immunoglobulin G1 variants productively engage activating Fc receptors. Proceedings of the National Academy of Sciences of the United States of America. 105: 20167-72. PMID 19074274 DOI: 10.1073/pnas.0809257105  0.96
2008 Antipov E, Cho AE, Wittrup KD, Klibanov AM. Highly L and D enantioselective variants of horseradish peroxidase discovered by an ultrahigh-throughput selection method. Proceedings of the National Academy of Sciences of the United States of America. 105: 17694-9. PMID 19004779 DOI: 10.1073/pnas.0809851105  0.96
2008 Bai A, Higham E, Eisen HN, Wittrup KD, Chen J. Rapid tolerization of virus-activated tumor-specific CD8+ T cells in prostate tumors of TRAMP mice. Proceedings of the National Academy of Sciences of the United States of America. 105: 13003-8. PMID 18723683 DOI: 10.1073/pnas.0805599105  0.96
2008 Ackerman ME, Pawlowski D, Wittrup KD. Effect of antigen turnover rate and expression level on antibody penetration into tumor spheroids. Molecular Cancer Therapeutics. 7: 2233-40. PMID 18645032 DOI: 10.1158/1535-7163.MCT-08-0067  0.96
2008 Howland SW, Tsuji T, Gnjatic S, Ritter G, Old LJ, Wittrup KD. Inducing efficient cross-priming using antigen-coated yeast particles. Journal of Immunotherapy (Hagerstown, Md. : 1997). 31: 607-19. PMID 18600183 DOI: 10.1097/CJI.0b013e318181c87f  0.96
2008 Thurber GM, Schmidt MM, Wittrup KD. Antibody tumor penetration: transport opposed by systemic and antigen-mediated clearance. Advanced Drug Delivery Reviews. 60: 1421-34. PMID 18541331 DOI: 10.1016/j.addr.2008.04.012  0.96
2008 Thurber GM, Wittrup KD. Quantitative spatiotemporal analysis of antibody fragment diffusion and endocytic consumption in tumor spheroids. Cancer Research. 68: 3334-41. PMID 18451160 DOI: 10.1158/0008-5472.CAN-07-3018  0.96
2008 Howarth M, Liu W, Puthenveetil S, Zheng Y, Marshall LF, Schmidt MM, Wittrup KD, Bawendi MG, Ting AY. Monovalent, reduced-size quantum dots for imaging receptors on living cells. Nature Methods. 5: 397-9. PMID 18425138 DOI: 10.1038/nmeth.1206  0.96
2008 Schmidt MM, Thurber GM, Wittrup KD. Kinetics of anti-carcinoembryonic antigen antibody internalization: effects of affinity, bivalency, and stability. Cancer Immunology, Immunotherapy : Cii. 57: 1879-90. PMID 18408925 DOI: 10.1007/s00262-008-0518-1  0.96
2008 Ackerman ME, Chalouni C, Schmidt MM, Raman VV, Ritter G, Old LJ, Mellman I, Wittrup KD. A33 antigen displays persistent surface expression. Cancer Immunology, Immunotherapy : Cii. 57: 1017-27. PMID 18236042 DOI: 10.1007/s00262-007-0433-x  0.96
2008 Howland SW, Wittrup KD. Antigen release kinetics in the phagosome are critical to cross-presentation efficiency. Journal of Immunology (Baltimore, Md. : 1950). 180: 1576-83. PMID 18209053  0.96
2008 Thurber GM, Schmidt MM, Wittrup KD. Factors determining antibody distribution in tumors. Trends in Pharmacological Sciences. 29: 57-61. PMID 18179828 DOI: 10.1016/j.tips.2007.11.004  0.96
2008 Higham EM, Wittrup KD. Tumor-induced T cell tolerance in a prostate cancer model Aiche Annual Meeting, Conference Proceedings 0.96
2007 Yeung YA, Finney AH, Koyrakh IA, Lebowitz MS, Ghanbari HA, Wands JR, Wittrup KD. Isolation and characterization of human antibodies targeting human aspartyl (asparaginyl) beta-hydroxylase. Human Antibodies. 16: 163-76. PMID 18334751  0.96
2007 Lipovsek D, Antipov E, Armstrong KA, Olsen MJ, Klibanov AM, Tidor B, Wittrup KD. Selection of horseradish peroxidase variants with enhanced enantioselectivity by yeast surface display. Chemistry & Biology. 14: 1176-85. PMID 17961829 DOI: 10.1016/j.chembiol.2007.09.008  0.96
2007 Lippow SM, Wittrup KD, Tidor B. Computational design of antibody-affinity improvement beyond in vivo maturation. Nature Biotechnology. 25: 1171-6. PMID 17891135 DOI: 10.1038/nbt1336  0.96
2007 Gai SA, Wittrup KD. Yeast surface display for protein engineering and characterization. Current Opinion in Structural Biology. 17: 467-73. PMID 17870469 DOI: 10.1016/j.sbi.2007.08.012  0.96
2007 Campbell CJ, Wittrup KD. Protein technologies. Current Opinion in Biotechnology. 18: 293-4. PMID 17681776 DOI: 10.1016/j.copbio.2007.07.011  0.96
2007 Thurber GM, Zajic SC, Wittrup KD. Theoretic criteria for antibody penetration into solid tumors and micrometastases. Journal of Nuclear Medicine : Official Publication, Society of Nuclear Medicine. 48: 995-9. PMID 17504872 DOI: 10.2967/jnumed.106.037069  0.96
2007 Lipovsek D, Lippow SM, Hackel BJ, Gregson MW, Cheng P, Kapila A, Wittrup KD. Evolution of an interloop disulfide bond in high-affinity antibody mimics based on fibronectin type III domain and selected by yeast surface display: molecular convergence with single-domain camelid and shark antibodies. Journal of Molecular Biology. 368: 1024-41. PMID 17382960 DOI: 10.1016/j.jmb.2007.02.029  0.96
2007 Krauland EM, Peelle BR, Wittrup KD, Belcher AM. Peptide tags for enhanced cellular and protein adhesion to single-crystalline sapphire. Biotechnology and Bioengineering. 97: 1009-20. PMID 17238208 DOI: 10.1002/bit.21341  0.96
2006 Chao G, Lau WL, Hackel BJ, Sazinsky SL, Lippow SM, Wittrup KD. Isolating and engineering human antibodies using yeast surface display. Nature Protocols. 1: 755-68. PMID 17406305 DOI: 10.1038/nprot.2006.94  0.96
2006 Swers JS, Widom A, Phan U, Springer TA, Wittrup KD. A high affinity human antibody antagonist of P-selectin mediated rolling. Biochemical and Biophysical Research Communications. 350: 508-13. PMID 17027652 DOI: 10.1016/j.bbrc.2006.08.197  0.96
2006 Rakestraw JA, Baskaran AR, Wittrup KD. A flow cytometric assay for screening improved heterologous protein secretion in yeast. Biotechnology Progress. 22: 1200-8. PMID 16889399 DOI: 10.1021/bp0600233  0.96
2006 Cochran JR, Kim YS, Lippow SM, Rao B, Wittrup KD. Improved mutants from directed evolution are biased to orthologous substitutions. Protein Engineering, Design & Selection : Peds. 19: 245-53. PMID 16740523 DOI: 10.1093/protein/gzl006  0.96
2006 Colby DW, Cassady JP, Lin GC, Ingram VM, Wittrup KD. Stochastic kinetics of intracellular huntingtin aggregate formation. Nature Chemical Biology. 2: 319-23. PMID 16699519 DOI: 10.1038/nchembio792  0.96
2006 Piatesi A, Howland SW, Rakestraw JA, Renner C, Robson N, Cebon J, Maraskovsky E, Ritter G, Old L, Wittrup KD. Directed evolution for improved secretion of cancer-testis antigen NY-ESO-1 from yeast. Protein Expression and Purification. 48: 232-42. PMID 16563796 DOI: 10.1016/j.pep.2006.01.026  0.96
2006 Sivasubramanian A, Chao G, Pressler HM, Wittrup KD, Gray JJ. Structural model of the mAb 806-EGFR complex using computational docking followed by computational and experimental mutagenesis. Structure (London, England : 1993). 14: 401-14. PMID 16531225 DOI: 10.1016/j.str.2005.11.022  0.96
2006 Midelfort KS, Wittrup KD. Context-dependent mutations predominate in an engineered high-affinity single chain antibody fragment. Protein Science : a Publication of the Protein Society. 15: 324-34. PMID 16434745 DOI: 10.1110/ps.051842406  0.96
2006 Kim YS, Bhandari R, Cochran JR, Kuriyan J, Wittrup KD. Directed evolution of the epidermal growth factor receptor extracellular domain for expression in yeast. Proteins. 62: 1026-35. PMID 16355407 DOI: 10.1002/prot.20618  0.96
2006 Rakestraw A, Wittrup KD. Contrasting secretory processing of simultaneously expressed heterologous proteins in Saccharomyces cerevisiae. Biotechnology and Bioengineering. 93: 896-905. PMID 16333864 DOI: 10.1002/bit.20780  0.96
2005 Peelle BR, Krauland EM, Wittrup KD, Belcher AM. Probing the interface between biomolecules and inorganic materials using yeast surface display and genetic engineering. Acta Biomaterialia. 1: 145-54. PMID 16701791 DOI: 10.1016/j.actbio.2004.11.004  0.96
2005 Rao BM, Driver I, Lauffenburger DA, Wittrup KD. High-affinity CD25-binding IL-2 mutants potently stimulate persistent T cell growth. Biochemistry. 44: 10696-701. PMID 16060678 DOI: 10.1021/bi050436x  0.96
2005 Rao BM, Lauffenburger DA, Wittrup KD. Integrating cell-level kinetic modeling into the design of engineered protein therapeutics. Nature Biotechnology. 23: 191-4. PMID 15696150 DOI: 10.1038/nbt1064  0.96
2005 Chakraborty AK, Debenedetti PG, Ottino JM, Davis ME, Keasling JD, Deem MW, Wittrup KD, Anseth K, Futran M, Georgiou G, Hammer DA, Stephanopoulos G. Preface to perspectives Aiche Journal. 51: 3082. DOI: 10.1002/aic.10728  0.96
2005 Wittrup KD. Directed evolution in chemical engineering Aiche Journal. 51: 3084-3085. DOI: 10.1002/aic.10706  0.96
2005 Chao G, Olsen M, Wolf-Yadlin A, Wittrup KD. Engineering antibodies against the epidermal growth factor receptor to block dimerization Aiche Annual Meeting, Conference Proceedings. 9137.  0.96
2005 Sivasubramanian A, Chao G, Wittrup KD, Gray JJ. Computational prediction of the mab 806-egfr complex structure by combining protein docking with computational and experimental mutagenesis Aiche Annual Meeting, Conference Proceedings. 8064.  0.96
2005 Lippow SM, Tidor B, Wittrup KD. Antibody affinity maturation using computational protein design Aiche Annual Meeting, Conference Proceedings. 10505.  0.96
2004 Colby DW, Chu Y, Cassady JP, Duennwald M, Zazulak H, Webster JM, Messer A, Lindquist S, Ingram VM, Wittrup KD. Potent inhibition of huntingtin aggregation and cytotoxicity by a disulfide bond-free single-domain intracellular antibody. Proceedings of the National Academy of Sciences of the United States of America. 101: 17616-21. PMID 15598740 DOI: 10.1073/pnas.0408134101  0.96
2004 Midelfort KS, Hernandez HH, Lippow SM, Tidor B, Drennan CL, Wittrup KD. Substantial energetic improvement with minimal structural perturbation in a high affinity mutant antibody. Journal of Molecular Biology. 343: 685-701. PMID 15465055 DOI: 10.1016/j.jmb.2004.08.019  0.96
2004 Rao BM, Driver I, Lauffenburger DA, Wittrup KD. Interleukin 2 (IL-2) variants engineered for increased IL-2 receptor alpha-subunit affinity exhibit increased potency arising from a cell surface ligand reservoir effect. Molecular Pharmacology. 66: 864-9. PMID 15385640 DOI: 10.1124/mol.66.4.  0.96
2004 Colby DW, Garg P, Holden T, Chao G, Webster JM, Messer A, Ingram VM, Wittrup KD. Development of a human light chain variable domain (V(L)) intracellular antibody specific for the amino terminus of huntingtin via yeast surface display. Journal of Molecular Biology. 342: 901-12. PMID 15342245 DOI: 10.1016/j.jmb.2004.07.054  0.96
2004 Chao G, Cochran JR, Wittrup KD. Fine epitope mapping of anti-epidermal growth factor receptor antibodies through random mutagenesis and yeast surface display. Journal of Molecular Biology. 342: 539-50. PMID 15327953 DOI: 10.1016/j.jmb.2004.07.053  0.36
2004 Colby DW, Kellogg BA, Graff CP, Yeung YA, Swers JS, Wittrup KD. Engineering antibody affinity by yeast surface display. Methods in Enzymology. 388: 348-58. PMID 15289082 DOI: 10.1016/S0076-6879(04)88027-3  0.96
2004 Graff CP, Chester K, Begent R, Wittrup KD. Directed evolution of an anti-carcinoembryonic antigen scFv with a 4-day monovalent dissociation half-time at 37 degrees C. Protein Engineering, Design & Selection : Peds. 17: 293-304. PMID 15115853 DOI: 10.1093/protein/gzh038  0.96
2004 Cochran JR, Kim YS, Olsen MJ, Bhandari R, Wittrup KD. Domain-level antibody epitope mapping through yeast surface display of epidermal growth factor receptor fragments. Journal of Immunological Methods. 287: 147-58. PMID 15099763 DOI: 10.1016/j.jim.2004.01.024  0.96
2004 Johns TG, Adams TE, Cochran JR, Hall NE, Hoyne PA, Olsen MJ, Kim YS, Rothacker J, Nice EC, Walker F, Ritter G, Jungbluth AA, Old LJ, Ward CW, Burgess AW, ... Wittrup KD, et al. Identification of the epitope for the epidermal growth factor receptor-specific monoclonal antibody 806 reveals that it preferentially recognizes an untethered form of the receptor. The Journal of Biological Chemistry. 279: 30375-84. PMID 15075331 DOI: 10.1074/jbc.M401218200  0.96
2004 Swers JS, Kellogg BA, Wittrup KD. Shuffled antibody libraries created by in vivo homologous recombination and yeast surface display. Nucleic Acids Research. 32: e36. PMID 14978223 DOI: 10.1093/nar/gnh030  0.96
2004 Coughlan CM, Walker JL, Cochran JC, Wittrup KD, Brodsky JL. Degradation of mutated bovine pancreatic trypsin inhibitor in the yeast vacuole suggests post-endoplasmic reticulum protein quality control. The Journal of Biological Chemistry. 279: 15289-97. PMID 14744871 DOI: 10.1074/jbc.M309673200  0.96
2004 Grovender EA, Kellogg B, Singh J, Blom D, Ploegh H, Wittrup KD, Langer RS, Ameer GA. Single-chain antibody fragment-based adsorbent for the extracorporeal removal of beta2-microglobulin. Kidney International. 65: 310-22. PMID 14675065 DOI: 10.1111/j.1523-1755.2004.00377.x  0.96
2003 Rao BM, Girvin AT, Ciardelli T, Lauffenburger DA, Wittrup KD. Interleukin-2 mutants with enhanced alpha-receptor subunit binding affinity. Protein Engineering. 16: 1081-7. PMID 14983090 DOI: 10.1093/protein/gzg111  0.96
2003 Bhatia SK, Swers JS, Camphausen RT, Wittrup KD, Hammer DA. Rolling adhesion kinematics of yeast engineered to express selectins. Biotechnology Progress. 19: 1033-7. PMID 12790675 DOI: 10.1021/bp025756b  0.96
2003 Orr BA, Carr LM, Wittrup KD, Roy EJ, Kranz DM. Rapid method for measuring ScFv thermal stability by yeast surface display. Biotechnology Progress. 19: 631-8. PMID 12675608 DOI: 10.1021/bp0200797  0.96
2003 Graff CP, Wittrup KD. Theoretical analysis of antibody targeting of tumor spheroids: importance of dosage for penetration, and affinity for retention. Cancer Research. 63: 1288-96. PMID 12649189  0.96
2003 Feldhaus MJ, Siegel RW, Opresko LK, Coleman JR, Feldhaus JM, Yeung YA, Cochran JR, Heinzelman P, Colby D, Swers J, Graff C, Wiley HS, Wittrup KD. Flow-cytometric isolation of human antibodies from a nonimmune Saccharomyces cerevisiae surface display library. Nature Biotechnology. 21: 163-70. PMID 12536217 DOI: 10.1038/nbt785  0.96
2002 Yeung YA, Wittrup KD. Quantitative screening of yeast surface-displayed polypeptide libraries by magnetic bead capture Biotechnology Progress. 18: 212-220. PMID 11934287 DOI: 10.1021/bp010186l  0.96
2002 Bhatia SK, Swers JS, Camphausen RT, Wittrup KD, Hammer DA. Yeast surface display of cell adhesion molecules: A tool for molecular evolution and cellular motion characterization Annual International Conference of the Ieee Engineering in Medicine and Biology - Proceedings. 1: 732-733.  0.96
2001 Wittrup KD. Protein engineering by cell-surface display Current Opinion in Biotechnology. 12: 395-399. PMID 11551469 DOI: 10.1016/S0958-1669(00)00233-0  0.96
2001 Kieke MC, Sundberg E, Shusta EV, Mariuzza RA, Wittrup KD, Kranz DM. High affinity T cell receptors from yeast display libraries block T cell activation by superantigens. Journal of Molecular Biology. 307: 1305-15. PMID 11292343 DOI: 10.1006/jmbi.2001.4560  0.96
2000 Boder ET, Wittrup KD. Yeast surface display for directed evolution of protein expression, affinity, and stability Methods in Enzymology. 328: 430-444. PMID 11075358  0.96
2000 Wittrup KD. The single cell as a microplate well Nature Biotechnology. 18: 1039-1040. PMID 11017037  0.96
2000 Boder ET, Midelfort KS, Wittrup KD. Directed evolution of antibody fragments with monovalent femtomolar antigen-binding affinity Proceedings of the National Academy of Sciences of the United States of America. 97: 10701-10705. PMID 10984501  0.96
2000 Shusta EV, Holler PD, Kieke MC, Kranz DM, Wittrup KD. Directed evolution of a stable scaffold for T-cell receptor engineering. Nature Biotechnology. 18: 754-9. PMID 10888844 DOI: 10.1038/77325  0.96
2000 Holler PD, Holman PO, Shusta EV, O'Herrin S, Wittrup KD, Kranz DM. In vitro evolution of a T cell receptor with high affinity for peptide/MHC. Proceedings of the National Academy of Sciences of the United States of America. 97: 5387-92. PMID 10779548 DOI: 10.1073/pnas.080078297  0.96
2000 Bannister SJ, Wittrup KD. Glutathione excretion in response to heterologous protein secretion in Saccharomyces cerevisiae. Biotechnology and Bioengineering. 68: 389-95. PMID 10745207 DOI: 10.1002/(SICI)1097-0290(20000520)68:4<389::AID-BIT4>3.0.CO;2-N  0.96
2000 VanAntwerp JJ, Wittrup KD. Fine affinity discrimination by yeast surface display and flow cytometry Biotechnology Progress. 16: 31-37. PMID 10662486 DOI: 10.1021/bp990133s  0.96
1999 Woycechowsky KJ, Wittrup KD, Raines RT. A small-molecule catalyst of protein folding in vitro and in vivo. Chemistry & Biology. 6: 871-9. PMID 10631515 DOI: 10.1016/S1074-5521(00)80006-X  0.96
1999 Wittrup KD. Phage on display Trends in Biotechnology. 17: 423-424. PMID 10610089 DOI: 10.1016/S0167-7799(99)01349-9  0.96
1999 Shusta EV, Kieke MC, Parke E, Kranz DM, Wittrup KD. Yeast polypeptide fusion surface display levels predict thermal stability and soluble secretion efficiency. Journal of Molecular Biology. 292: 949-56. PMID 10512694 DOI: 10.1006/jmbi.1999.3130  0.96
1999 Becker F, Block-Alper L, Nakamura G, Harada J, Wittrup KD, Meyer DI. Expression of the 180-kD ribosome receptor induces membrane proliferation and increased secretory activity in yeast Journal of Cell Biology. 146: 273-284. PMID 10427084 DOI: 10.1083/jcb.146.2.273  0.96
1999 Kieke MC, Shusta EV, Boder ET, Teyton L, Wittrup KD, Kranz DM. Selection of functional T cell receptor mutants from a yeast surface-display library. Proceedings of the National Academy of Sciences of the United States of America. 96: 5651-6. PMID 10318939 DOI: 10.1073/pnas.96.10.5651  0.96
1999 Shusta EV, Vanantwerp J, Wittrup KD. Biosynthetic polypeptide libraries Current Opinion in Biotechnology. 10: 117-122. PMID 10209135 DOI: 10.1016/S0958-1669(99)80020-2  0.96
1998 Arnold CE, Parekh RN, Yang W, Wittrup KD. Leader peptide efficiency correlates with signal recognition particle dependence in Saccharomyces cerevisiae. Biotechnology and Bioengineering. 59: 286-93. PMID 10099339 DOI: 10.1002/(SICI)1097-0290(19980805)59:3<286::AID-BIT4>3.0.CO;2-7  0.96
1998 VanAntwerp JJ, Wittrup KD. Thermodynamic characterization of affinity maturation: The D1.3 antibody and a higher-affinity mutant Journal of Molecular Recognition. 11: 10-13. PMID 10076798  0.96
1998 Cho BK, Kieke MC, Boder ET, Wittrup KD, Kranz DM. A yeast surface display system for the discovery of ligands that trigger cell activation. Journal of Immunological Methods. 220: 179-88. PMID 9839939 DOI: 10.1016/S0022-1759(98)00158-6  0.96
1998 Kowalski JM, Kelly RM, Konisky J, Clark DS, Wittrup KD. Purification and functional characterization of a chaperone from Methanococcus jannaschii Systematic and Applied Microbiology. 21: 173-178. PMID 9704106  0.96
1998 Shusta EV, Raines RT, Plückthun A, Wittrup KD. Increasing the secretory capacity of Saccharomyces cerevisiae for production of single-chain antibody fragments Nature Biotechnology. 16: 773-777. PMID 9702778 DOI: 10.1038/nbt0898-773  0.96
1998 Kowalski JM, Parekh RN, Mao J, Wittrup KD. Protein folding stability can determine the efficiency of escape from endoplasmic reticulum quality control. The Journal of Biological Chemistry. 273: 19453-8. PMID 9677365 DOI: 10.1074/jbc.273.31.19453  0.96
1998 Kowalski JM, Parekh RN, Wittrup KD. Secretion efficiency in Saccharomyces cerevisiae of bovine pancreatic trypsin inhibitor mutants lacking disulfide bonds is correlated with thermodynamic stability. Biochemistry. 37: 1264-73. PMID 9477952 DOI: 10.1021/bi9722397  0.96
1997 Kieke MC, Cho BK, Boder ET, Kranz DM, Wittrup KD. Isolation of anti-T cell receptor scFv mutants by yeast surface display. Protein Engineering. 10: 1303-10. PMID 9514119  0.96
1997 Boder ET, Wittrup KD. Yeast surface display for screening combinatorial polypeptide libraries Nature Biotechnology. 15: 553-557. PMID 9181578  0.96
1997 Parekh RN, Wittrup KD. Expression level tuning for optimal heterologous protein secretion in Saccharomyces cerevisiae. Biotechnology Progress. 13: 117-22. PMID 9104035 DOI: 10.1021/bp970009d  0.96
1996 Parekh RN, Shaw MR, Wittrup KD. An integrating vector for tunable, high copy, stable integration into the dispersed Ty delta sites of Saccharomyces cerevisiae. Biotechnology Progress. 12: 16-21. PMID 8845105 DOI: 10.1021/bp9500627  0.4
1996 Robinson AS, Bockhaus JA, Voegler AC, Wittrup KD. Reduction of BiP levels decreases heterologous protein secretion in Saccharomyces cerevisiae Journal of Biological Chemistry. 271: 10017-10022. PMID 8626555 DOI: 10.1074/jbc.271.17.10017  0.96
1996 Zabriskie DW, Wittrup KD. Preface: Biochemical Engineering IX - Interdisciplinary Foundations for Creating New Biotechnology: I Biotechnology and Bioengineering. 52: 1-2.  0.96
1996 Zabriskie DW, Wittrup KD. Biochemical Engineering IX - Interdisciplinary foundations for creating new biotechnology: II Biotechnology and Bioengineering. 52: 183.  0.96
1995 Wittrup KD. Disulfide bond formation and eukaryotic secretory productivity Current Opinion in Biotechnology. 6: 203-208. PMID 7734749 DOI: 10.1016/0958-1669(95)80033-6  0.96
1995 Robinson AS, Wittrup KD. Constitutive overexpression of secreted heterologous proteins decreases extractable BiP and protein disulfide isomerase levels in Saccharomyces cerevisiae Biotechnology Progress. 11: 171-177. PMID 7536423  0.96
1994 Arnold CE, Wittrup KD. The stress response to loss of signal recognition particle function in Saccharomyces cerevisiae Journal of Biological Chemistry. 269: 30412-30418. PMID 7982955  0.96
1994 Wittrup KD, Westerman RJ, Desai R. Fluorescence array detector for large-field quantitative fluorescence cytometry Cytometry. 16: 206-213. PMID 7924689 DOI: 10.1002/cyto.990160304  0.96
1994 Wittrup KD, Robinson AS, Parekh RN, Forrester KJ. Existence of an optimum expression level for secretion of foreign proteins in yeast. Annals of the New York Academy of Sciences. 745: 321-30. PMID 7530433  0.96
1994 Robinson AS, Hines V, Wittrup KD. Protein disulfide isomerase overexpression increases secretion of foreign proteins in Saccharomyces cerevisiae Nature Biotechnology. 12: 381-384. DOI: 10.1038/nbt0494-381  0.96
1994 Wittrup KD, Benig V. Optimization of amino acid supplements for heterologous protein secretion in Saccharomyces cerevisiae Biotechnology Techniques. 8: 161-166. DOI: 10.1007/BF00161582  0.96
1993 Wittrup KD, Weber AL, Tsai P. Microencapsulation selection for isolation of yeast mutants with increased secretion of Aspergillus awamori glucoamylase Biotechnology and Bioengineering. 42: 351-356.  0.96
1991 Wittrup KD, Bailey JE. Comments on a segregated model of recombinant cultures: authors' reply. Biotechnology and Bioengineering. 38: 1364-5. PMID 18600738 DOI: 10.1002/bit.260381114  0.96
1990 Wittrup KD, Bailey JE, Ratzkin B, Patel A. Propagation of an amplifiable recombinant plasmid in Saccharomyces cerevisiae: flow cytometry studies and segregated modeling. Biotechnology and Bioengineering. 35: 565-77. PMID 18592552 DOI: 10.1002/bit.260350604  0.96
1990 Wittrup KD, Bailey JE. Mathematical modeling of a single-cell enzyme assay. Biotechnology and Bioengineering. 35: 525-32. PMID 18592546 DOI: 10.1002/bit.260350511  0.96
1990 Meilhoc E, Wittrup KD, Bailey JE. Influence of dissolved oxygen concentration on growth, mitochondrial function and antibody production of hybridoma cells in batch culture Bioprocess Engineering. 5: 263-274. DOI: 10.1007/BF00369376  0.96
1989 Meilhoc E, Wittrup KD, Bailey JE. Application of flow cytometric measurement of surface IgG in kinetic analysis of monoclonal antibody synthesis and secretion by murine hybridoma cells. Journal of Immunological Methods. 121: 167-74. PMID 2760464 DOI: 10.1016/0022-1759(89)90157-9  0.96
1989 Budd ME, Wittrup KD, Bailey JE, Campbell JL. DNA polymerase I is required for premeiotic DNA replication and sporulation but not for X-ray repair in Saccharomyces cerevisiae. Molecular and Cellular Biology. 9: 365-76. PMID 2651896  0.96
1988 Wittrup KD, Bailey JE. A segregated model of recombinant multicopy plasmid propagation. Biotechnology and Bioengineering. 31: 304-10. PMID 18584609 DOI: 10.1002/bit.260310405  0.96
1988 Wittrup KD, Bailey JE. A single-cell assay of beta-galactosidase activity in Saccharomyces cerevisiae. Cytometry. 9: 394-404. PMID 3135986 DOI: 10.1002/cyto.990090418  0.96
1988 Wittrup KD, Bailey JE. A mathematical model of recombinational amplification of the 2 mu plasmid in the yeast Saccharomyces cerevisiae. Journal of Theoretical Biology. 130: 481-92. PMID 3054338  0.96
1988 Wittrup KD, Bailey JE. SEGREGATED MODEL OF RECOMBINANT MULTICOPY PLASMID PROPAGATION Biotechnology and Bioengineering. 31: 304-310.  0.96
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