K. Dane Wittrup - Publications

Affiliations: 
1989-1999 Chemical Engineering University of Illinois, Urbana-Champaign, Urbana-Champaign, IL 
 1999- Chemical Engineering and Biological Engineering Massachusetts Institute of Technology, Cambridge, MA, United States 
Website:
https://be.mit.edu/directory/k-dane-wittrup

159 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2020 Mehta NK, Pradhan RV, Soleimany AP, Moynihan KD, Rothschilds AM, Momin N, Rakhra K, Mata-Fink J, Bhatia SN, Wittrup KD, Irvine DJ. Pharmacokinetic tuning of protein-antigen fusions enhances the immunogenicity of T-cell vaccines. Nature Biomedical Engineering. PMID 32483299 DOI: 10.1038/S41551-020-0563-4  0.316
2019 Ma L, Dichwalkar T, Chang JYH, Cossette B, Garafola D, Zhang AQ, Fichter M, Wang C, Liang S, Silva M, Kumari S, Mehta NK, Abraham W, Thai N, Li N, ... Wittrup KD, et al. Enhanced CAR-T cell activity against solid tumors by vaccine boosting through the chimeric receptor. Science (New York, N.Y.). 365: 162-168. PMID 31296767 DOI: 10.1126/Science.Aav8692  0.353
2019 Momin N, Mehta NK, Bennett NR, Ma L, Palmeri JR, Chinn MM, Lutz EA, Kang B, Irvine DJ, Spranger S, Wittrup KD. Anchoring of intratumorally administered cytokines to collagen safely potentiates systemic cancer immunotherapy. Science Translational Medicine. 11. PMID 31243150 DOI: 10.1126/Scitranslmed.Aaw2614  0.362
2019 Dréau D, Moore LJ, Wu M, Roy LD, Dillion L, Porter T, Puri R, Momin N, Wittrup KD, Mukherjee P. Combining the Specific Anti-MUC1 Antibody TAB004 and Lip-MSA-IL-2 Limits Pancreatic Cancer Progression in Immune Competent Murine Models of Pancreatic Ductal Adenocarcinoma. Frontiers in Oncology. 9: 330. PMID 31114758 DOI: 10.3389/Fonc.2019.00330  0.412
2019 Rothschilds A, Tzeng A, Mehta NK, Moynihan KD, Irvine DJ, Wittrup KD. Order of administration of combination cytokine therapies can decouple toxicity from efficacy in syngeneic mouse tumor models. Oncoimmunology. 8: e1558678. PMID 31069130 DOI: 10.1080/2162402X.2018.1558678  0.351
2018 Angelini A, Miyabe Y, Newsted D, Kwan BH, Miyabe C, Kelly RL, Jamy MN, Luster AD, Wittrup KD. Directed evolution of broadly crossreactive chemokine-blocking antibodies efficacious in arthritis. Nature Communications. 9: 1461. PMID 29654232 DOI: 10.1038/S41467-018-03687-X  0.431
2018 Kelly RL, Le D, Zhao J, Wittrup KD. Reduction of Nonspecificity Motifs in Synthetic Antibody Libraries. Journal of Molecular Biology. 430: 119-130. PMID 29183788 DOI: 10.1016/J.Jmb.2017.11.008  0.438
2017 Green DJ, O'Steen S, Lin Y, Comstock ML, Kenoyer AL, Hamlin DK, Wilbur DS, Fisher DR, Nartea M, Hylarides MD, Gopal AK, Gooley TA, Orozco JJ, Till BG, Orcutt KD, ... Wittrup KD, et al. CD38 bispecific antibody pretargeted radioimmunotherapy for multiple myeloma and other B cell malignancies. Blood. PMID 29158362 DOI: 10.1182/Blood-2017-09-807610  0.31
2017 Kelly RL, Zhao J, Le D, Wittrup KD. Nonspecificity in a nonimmune human scFv repertoire. Mabs. 0. PMID 28910564 DOI: 10.1080/19420862.2017.1356528  0.356
2017 Wittrup KD. Antitumor Antibodies Can Drive Therapeutic T Cell Responses. Trends in Cancer. 3: 615-620. PMID 28867165 DOI: 10.1016/J.Trecan.2017.07.001  0.409
2017 Kelly RL, Geoghegan JC, Feldman J, Jain T, Kauke M, Le D, Zhao J, Wittrup KD. Chaperone proteins as single component reagents to assess antibody nonspecificity. Mabs. 0. PMID 28745541 DOI: 10.1080/19420862.2017.1356529  0.432
2017 Cheal SM, Fung EK, Patel MV, Punzalan B, Xu H, Guo HF, Zanzonico PB, Monette S, Wittrup KD, Cheung NK, Larson SM. Curative multi-cycle radioimmunotherapy monitored by quantitative SPECT/CT-based theranostics, using bispecific antibody pretargeting strategy in colorectal cancer. Journal of Nuclear Medicine : Official Publication, Society of Nuclear Medicine. PMID 28705917 DOI: 10.2967/Jnumed.117.193250  0.324
2017 Chen TF, Sazinsky SL, Houde D, DiLillo DJ, Bird J, Li KK, Cheng GT, Qiu H, Engen JR, Ravetch JV, Wittrup KD. Engineering Aglycosylated IgG Variants with Wild-type or Improved Binding Affinity to Human Fc gamma RIIA and Fc gamma RIIIAs. Journal of Molecular Biology. PMID 28694069 DOI: 10.1016/J.Jmb.2017.07.001  0.408
2017 Yang NJ, Kauke MJ, Sun F, Yang LF, Maass KF, Traxlmayr MW, Yu Y, Xu Y, Langer RS, Anderson DG, Wittrup KD. Cytosolic delivery of siRNA by ultra-high affinity dsRNA binding proteins. Nucleic Acids Research. PMID 28641400 DOI: 10.1093/Nar/Gkx546  0.387
2017 Kwan BH, Zhu EF, Tzeng A, Sugito HR, Eltahir AA, Ma B, Delaney MK, Murphy PA, Kauke MJ, Angelini A, Momin N, Mehta NK, Maragh AM, Hynes RO, Dranoff G, ... ... Wittrup KD, et al. Integrin-targeted cancer immunotherapy elicits protective adaptive immune responses. The Journal of Experimental Medicine. PMID 28473400 DOI: 10.1084/Jem.20160831  0.636
2017 Smith TT, Moffett HF, Stephan SB, Opel CF, Dumigan AG, Jiang X, Pillarisetty VG, Pillai SPS, Wittrup KD, Stephan MT. Biopolymers codelivering engineered T cells and STING agonists can eliminate heterogeneous tumors. The Journal of Clinical Investigation. PMID 28436934 DOI: 10.1172/Jci87624  0.364
2017 Jain T, Sun T, Durand S, Hall A, Houston NR, Nett JH, Sharkey B, Bobrowicz B, Caffry I, Yu Y, Cao Y, Lynaugh H, Brown M, Baruah H, Gray LT, ... ... Wittrup KD, et al. Biophysical properties of the clinical-stage antibody landscape. Proceedings of the National Academy of Sciences of the United States of America. PMID 28096333 DOI: 10.1073/Pnas.1616408114  0.394
2017 Moynihan KD, Opel C, Szeto G, Tzeng A, Eric Z, Engreitz J, Robert W, Rakhra K, Zhang M, Rothschilds A, Kumari S, Kelly RL, Kwan B, Abraham W, Hu K, ... ... Wittrup KD, et al. Abstract A52: Eradication of large established tumors with combination immunotherapy engaging innate and adaptive immunity Cancer Immunology Research. 5. DOI: 10.1158/2326-6074.Tumimm16-A52  0.754
2016 Sharkey B, Pudi S, Wallace Moyer I, Zhong L, Prinz B, Baruah H, Lynaugh H, Kumar S, Wittrup KD, Nett JH. Purification of common light chain IgG-like bispecific antibodies using highly linear pH gradients. Mabs. 0. PMID 27937066 DOI: 10.1080/19420862.2016.1267090  0.343
2016 Tzeng A, Kauke MJ, Zhu EF, Moynihan KD, Opel CF, Yang NJ, Mehta N, Kelly RL, Szeto GL, Overwijk WW, Irvine DJ, Wittrup KD. Temporally Programmed CD8α(+) DC Activation Enhances Combination Cancer Immunotherapy. Cell Reports. 17: 2503-2511. PMID 27926855 DOI: 10.1016/J.Celrep.2016.11.020  0.729
2016 Moynihan KD, Opel CF, Szeto GL, Tzeng A, Zhu EF, Engreitz JM, Williams RT, Rakhra K, Zhang MH, Rothschilds AM, Kumari S, Kelly RL, Kwan BH, Abraham W, Hu K, ... ... Wittrup KD, et al. Eradication of large established tumors in mice by combination immunotherapy that engages innate and adaptive immune responses. Nature Medicine. PMID 27775706 DOI: 10.1038/Nm.4200  0.79
2016 Kelly RL, Yu Y, Sun T, Caffry I, Lynaugh H, Brown M, Jain T, Xu Y, Wittrup KD. Target-independent variable region mediated effects on antibody clearance can be FcRn independent. Mabs. 0. PMID 27610650 DOI: 10.1080/19420862.2016.1208330  0.425
2016 Green DJ, Frayo SL, Lin Y, Hamlin DK, Fisher DR, Frost SH, Kenoyer AL, Hylarides MD, Gopal AK, Gooley TA, Orozco JJ, Till BG, O'Steen S, Orcutt KD, Wilbur DS, ... Wittrup KD, et al. Comparative analysis of bispecific antibody and streptavidin-targeted radioimmunotherapy for B cell cancers. Cancer Research. PMID 27590740 DOI: 10.1158/0008-5472.Can-16-0571  0.381
2016 Traxlmayr MW, Kiefer JD, Srinivas RR, Lobner E, Tisdale AW, Mehta NK, Yang NJ, Tidor B, Wittrup KD. Strong Enrichment of Aromatic Residues in Binding Sites from a Charge-Neutralized Hyperthermostable Sso7d Scaffold Library. The Journal of Biological Chemistry. PMID 27582495 DOI: 10.1074/Jbc.M116.741314  0.394
2016 de Picciotto S, Dickson PM, Traxlmayr MW, Marques BS, Socher E, Zhao S, Cheung S, Kiefer J, Wand AJ, Griffith LG, Imperiali B, Wittrup KD. Design principles for reagentless biosensors: Specific fluorophore/analyte binding and minimization of fluorophore/scaffold interactions. Journal of Molecular Biology. PMID 27448945 DOI: 10.1016/J.Jmb.2016.07.004  0.331
2016 Singh AP, Maass KF, Betts AM, Wittrup KD, Kulkarni C, King LE, Khot A, Shah DK. Evolution of Antibody-Drug Conjugate Tumor Disposition Model to Predict Preclinical Tumor Pharmacokinetics of Trastuzumab-Emtansine (T-DM1). The Aaps Journal. PMID 27029797 DOI: 10.1208/S12248-016-9904-3  0.336
2016 Maass KF, Kulkarni C, Betts AM, Wittrup KD. Determination of Cellular Processing Rates for a Trastuzumab-Maytansinoid Antibody-Drug Conjugate (ADC) Highlights Key Parameters for ADC Design. The Aaps Journal. PMID 26912181 DOI: 10.1208/S12248-016-9892-3  0.374
2016 Schütz M, Batyuk A, Klenk C, Kummer L, de Picciotto S, Gülbakan B, Wu Y, Newby GA, Zosel F, Schöppe J, Sedlák E, Mittl PR, Zenobi R, Wittrup KD, Plückthun A. Generation of fluorogen-activating designed ankyrin repeat proteins (FADAs) as versatile sensor tools. Journal of Molecular Biology. PMID 26812208 DOI: 10.1016/J.Jmb.2016.01.017  0.331
2016 Zhu EF, Rakhra K, Mehta N, Moynihan KD, Opel CF, Irvine DJ, Wittrup KD. Abstract B120: Characterization and combination immunotherapy treatment of an inducible autochthonous murine lung cancer model expressing human carcinoembryonic antigen (CEA) as a tumor-associated self-antigen Cancer Immunology Research. 4. DOI: 10.1158/2326-6074.Cricimteatiaacr15-B120  0.42
2015 Cheal SM, Xu H, Guo HF, Lee SG, Punzalan B, Chalasani S, Fung EK, Jungbluth A, Zanzonico PB, Carrasquillo JA, O'Donoghue J, Smith-Jones PM, Wittrup KD, Cheung NV, Larson SM. Theranostic pretargeted radioimmunotherapy of colorectal cancer xenografts in mice using picomolar affinity (86)Y- or (177)Lu-DOTA-Bn binding scFv C825/GPA33 IgG bispecific immunoconjugates. European Journal of Nuclear Medicine and Molecular Imaging. PMID 26596724 DOI: 10.1007/S00259-015-3254-8  0.389
2015 Van Deventer JA, Kelly RL, Rajan S, Wittrup KD, Sidhu SS. A switchable yeast display/secretion system. Protein Engineering, Design & Selection : Peds. 28: 317-25. PMID 26333274 DOI: 10.1093/Protein/Gzv043  0.749
2015 Angelini A, Chen TF, de Picciotto S, Yang NJ, Tzeng A, Santos MS, Van Deventer JA, Traxlmayr MW, Wittrup KD. Protein Engineering and Selection Using Yeast Surface Display. Methods in Molecular Biology (Clifton, N.J.). 1319: 3-36. PMID 26060067 DOI: 10.1007/978-1-4939-2748-7_1  0.731
2015 Kelly RL, Sun T, Jain T, Caffry I, Yu Y, Cao Y, Lynaugh H, Brown M, Vásquez M, Wittrup KD, Xu Y. High throughput cross-interaction measures for human IgG1 antibodies correlate with clearance rates in mice. Mabs. 7: 770-7. PMID 26047159 DOI: 10.1080/19420862.2015.1043503  0.36
2015 Yang NJ, Liu DV, Sklaviadis D, Gui DY, Vander Heiden MG, Wittrup KD. Antibody-mediated neutralization of perfringolysin o for intracellular protein delivery. Molecular Pharmaceutics. 12: 1992-2000. PMID 25881713 DOI: 10.1021/Mp500797N  0.405
2015 Zhu EF, Gai SA, Opel CF, Kwan BH, Surana R, Mihm MC, Kauke MJ, Moynihan KD, Angelini A, Williams RT, Stephan MT, Kim JS, Yaffe MB, Irvine DJ, Weiner LM, ... ... Wittrup KD, et al. Synergistic innate and adaptive immune response to combination immunotherapy with anti-tumor antigen antibodies and extended serum half-life IL-2. Cancer Cell. 27: 489-501. PMID 25873172 DOI: 10.1016/J.Ccell.2015.03.004  0.431
2015 Tzeng A, Kwan BH, Opel CF, Navaratna T, Wittrup KD. Antigen specificity can be irrelevant to immunocytokine efficacy and biodistribution. Proceedings of the National Academy of Sciences of the United States of America. 112: 3320-5. PMID 25733854 DOI: 10.1073/Pnas.1416159112  0.436
2015 Wang S, Mata-Fink J, Kriegsman B, Hanson M, Irvine DJ, Eisen HN, Burton DR, Wittrup KD, Kardar M, Chakraborty AK. Manipulating the selection forces during affinity maturation to generate cross-reactive HIV antibodies. Cell. 160: 785-97. PMID 25662010 DOI: 10.1016/J.Cell.2015.01.027  0.413
2015 Rouha H, Badarau A, Visram ZC, Battles MB, Prinz B, Magyarics Z, Nagy G, Mirkina I, Stulik L, Zerbs M, Jägerhofer M, Maierhofer B, Teubenbacher A, Dolezilkova I, Gross K, ... ... Wittrup KD, et al. Five birds, one stone: neutralization of α-hemolysin and 4 bi-component leukocidins of Staphylococcus aureus with a single human monoclonal antibody. Mabs. 7: 243-54. PMID 25523282 DOI: 10.4161/19420862.2014.985132  0.391
2015 Green DJ, Jones JC, Lin Y, Frayo SL, Kenoyer AL, O'Steen S, Peters A, Frost SH, Orozco JJ, Gopal AK, Hylarides MD, Fisher DR, Sandmaier BM, Till BG, Balkin ER, ... ... Wittrup KD, et al. A Novel Bispecific CD38 Antibody Eradicates Multiple Myeloma in a Mouse Model Following Yttrium-90-DOTA Capture Blood. 126: 118-118. DOI: 10.1182/Blood.V126.23.118.118  0.34
2014 Yao X, Williamson C, Adalsteinsson VA, D'Agostino RS, Fitton T, Smaroff GG, William RT, Wittrup KD, Love JC. Tumor cells are dislodged into the pulmonary vein during lobectomy. The Journal of Thoracic and Cardiovascular Surgery. 148: 3224-31.e1-5. PMID 25172322 DOI: 10.1016/J.Jtcvs.2014.06.074  0.317
2014 Liu DV, Yang NJ, Wittrup KD. A Nonpolycationic Fully Proteinaceous Multiagent System for Potent Targeted Delivery of siRNA. Molecular Therapy. Nucleic Acids. 3: e162. PMID 24825362 DOI: 10.1038/Mtna.2014.14  0.328
2014 Yao X, Choudhury AD, Yamanaka YJ, Adalsteinsson VA, Gierahn TM, Williamson CA, Lamb CR, Taplin ME, Nakabayashi M, Chabot MS, Li T, Lee GS, Boehm JS, Kantoff PW, Hahn WC, ... Wittrup KD, et al. Functional analysis of single cells identifies a rare subset of circulating tumor cells with malignant traits. Integrative Biology : Quantitative Biosciences From Nano to Macro. 6: 388-98. PMID 24522233 DOI: 10.1039/C3Ib40264A  0.31
2014 Van Deventer JA, Wittrup KD. Yeast surface display for antibody isolation: library construction, library screening, and affinity maturation. Methods in Molecular Biology (Clifton, N.J.). 1131: 151-81. PMID 24515465 DOI: 10.1007/978-1-62703-992-5_10  0.736
2014 Kenoyer AL, Lin Y, Orozco JJ, Balkin E, Hamlin D, Hernandez AH, Fang C, Laird K, Frost SH, Hylarides M, Orcutt KD, Wilbur DS, Wittrup KD, Press OW, Pagel J. Pre-Targeted Radioimmunotherapy Employing a Recombinant Bispecific Antibody Using a Murine Xenograft Model of Human Leukemia Blood. 124: 3749-3749. DOI: 10.1182/Blood.V124.21.3749.3749  0.312
2013 Bak SP, Barnkob MS, Wittrup KD, Chen J. CD8+ T-cell responses rapidly select for antigen-negative tumor cells in the prostate. Cancer Immunology Research. 1: 393-401. PMID 24778132 DOI: 10.1158/2326-6066.Cir-13-0109  0.358
2013 Schmidt MM, Townson SA, Andreucci AJ, King BM, Schirmer EB, Murillo AJ, Dombrowski C, Tisdale AW, Lowden PA, Masci AL, Kovalchin JT, Erbe DV, Wittrup KD, Furfine ES, Barnes TM. Crystal structure of an HSA/FcRn complex reveals recycling by competitive mimicry of HSA ligands at a pH-dependent hydrophobic interface. Structure (London, England : 1993). 21: 1966-78. PMID 24120761 DOI: 10.1016/J.Str.2013.08.022  0.321
2013 Xu Y, Roach W, Sun T, Jain T, Prinz B, Yu TY, Torrey J, Thomas J, Bobrowicz P, Vásquez M, Wittrup KD, Krauland E. Addressing polyspecificity of antibodies selected from an in vitro yeast presentation system: a FACS-based, high-throughput selection and analytical tool. Protein Engineering, Design & Selection : Peds. 26: 663-70. PMID 24046438 DOI: 10.1093/Protein/Gzt047  0.317
2013 Adalsteinsson VA, Tahirova N, Tallapragada N, Yao X, Campion L, Angelini A, Douce TB, Huang C, Bowman B, Williamson CA, Kwon DS, Wittrup KD, Love JC. Single cells from human primary colorectal tumors exhibit polyfunctional heterogeneity in secretions of ELR+ CXC chemokines. Integrative Biology : Quantitative Biosciences From Nano to Macro. 5: 1272-81. PMID 23995780 DOI: 10.1039/C3Ib40059J  0.347
2013 Pirie CM, Liu DV, Wittrup KD. Targeted cytolysins synergistically potentiate cytoplasmic delivery of gelonin immunotoxin. Molecular Cancer Therapeutics. 12: 1774-82. PMID 23832121 DOI: 10.1158/1535-7163.Mct-12-1023  0.372
2013 Yao X, Labelle M, Lamb CR, Dugan JM, Williamson CA, Spencer DR, Christ KR, Keating RO, Lee WD, Paradis GA, Begum S, Hynes RO, Wittrup KD. Determination of 35 cell surface antigen levels in malignant pleural effusions identifies CD24 as a marker of disseminated tumor cells. International Journal of Cancer. Journal International Du Cancer. 133: 2925-33. PMID 23775727 DOI: 10.1002/Ijc.28312  0.406
2013 Su X, Yang N, Wittrup KD, Irvine DJ. Synergistic antitumor activity from two-stage delivery of targeted toxins and endosome-disrupting nanoparticles. Biomacromolecules. 14: 1093-102. PMID 23444913 DOI: 10.1021/Bm3019906  0.349
2013 Kwong B, Gai SA, Elkhader J, Wittrup KD, Irvine DJ. Localized immunotherapy via liposome-anchored Anti-CD137 + IL-2 prevents lethal toxicity and elicits local and systemic antitumor immunity. Cancer Research. 73: 1547-58. PMID 23436794 DOI: 10.1158/0008-5472.Can-12-3343  0.361
2013 Chen TF, de Picciotto S, Hackel BJ, Wittrup KD. Engineering fibronectin-based binding proteins by yeast surface display. Methods in Enzymology. 523: 303-26. PMID 23422436 DOI: 10.1016/B978-0-12-394292-0.00014-X  0.7
2013 Yazaki PJ, Lee B, Channappa D, Cheung CW, Crow D, Chea J, Poku E, Li L, Andersen JT, Sandlie I, Orcutt KD, Wittrup KD, Shively JE, Raubitschek A, Colcher D. A series of anti-CEA/anti-DOTA bispecific antibody formats evaluated for pre-targeting: comparison of tumor uptake and blood clearance. Protein Engineering, Design & Selection : Peds. 26: 187-93. PMID 23175797 DOI: 10.1093/Protein/Gzs096  0.425
2013 Mata-Fink J, Kriegsman B, Yu HX, Zhu H, Hanson MC, Irvine DJ, Wittrup KD. Rapid conformational epitope mapping of anti-gp120 antibodies with a designed mutant panel displayed on yeast. Journal of Molecular Biology. 425: 444-56. PMID 23159556 DOI: 10.1016/J.Jmb.2012.11.010  0.394
2013 Opel CF, Wittrup KD. Combined treatment using adoptive cell therapy, extended pharmacokinetic IL-2, and tumor-specific antibodies leads to cures of established B16F10 tumors and extended in vivo T cell survival Journal For Immunotherapy of Cancer. 1. DOI: 10.1186/2051-1426-1-S1-P26  0.408
2013 Chen TF, Li K, Wittrup KD. Abstract 1250: Fibronectin domains engineered for specificity to individual murine Fc gamma receptors modulate tumoricidal activity of immune cells. Cancer Research. 73: 1250-1250. DOI: 10.1158/1538-7445.Am2013-1250  0.477
2013 Yao X, Choudhury AD, Yamanaka YJ, Hahn WC, Wittrup KD, Love JC. Abstract C23: Functional characterization of viable circulating tumor cells using nanowells. Molecular Cancer Therapeutics. 12. DOI: 10.1158/1535-7163.Targ-13-C23  0.318
2012 Thurber GM, Wittrup KD. A mechanistic compartmental model for total antibody uptake in tumors. Journal of Theoretical Biology. 314: 57-68. PMID 22974563 DOI: 10.1016/J.Jtbi.2012.08.034  0.706
2012 Spangler JB, Manzari MT, Rosalia EK, Chen TF, Wittrup KD. Triepitopic antibody fusions inhibit cetuximab-resistant BRAF and KRAS mutant tumors via EGFR signal repression. Journal of Molecular Biology. 422: 532-44. PMID 22706026 DOI: 10.1016/J.Jmb.2012.06.014  0.731
2012 Orcutt KD, Rhoden JJ, Ruiz-Yi B, Frangioni JV, Wittrup KD. Effect of small-molecule-binding affinity on tumor uptake in vivo: a systematic study using a pretargeted bispecific antibody. Molecular Cancer Therapeutics. 11: 1365-72. PMID 22491799 DOI: 10.1158/1535-7163.Mct-11-0764  0.415
2012 Wittrup KD, Thurber GM, Schmidt MM, Rhoden JJ. Practical theoretic guidance for the design of tumor-targeting agents. Methods in Enzymology. 503: 255-68. PMID 22230572 DOI: 10.1016/B978-0-12-396962-0.00010-0  0.691
2012 Hackel BJ, Neil JR, White FM, Wittrup KD. Epidermal growth factor receptor downregulation by small heterodimeric binding proteins. Protein Engineering, Design & Selection : Peds. 25: 47-57. PMID 22160867 DOI: 10.1093/Protein/Gzr056  0.68
2012 Rhoden JJ, Wittrup KD. Dose dependence of intratumoral perivascular distribution of monoclonal antibodies. Journal of Pharmaceutical Sciences. 101: 860-7. PMID 22057714 DOI: 10.1002/jps.22801  0.313
2011 Boersma YL, Chao G, Steiner D, Wittrup KD, Plückthun A. Bispecific designed ankyrin repeat proteins (DARPins) targeting epidermal growth factor receptor inhibit A431 cell proliferation and receptor recycling. The Journal of Biological Chemistry. 286: 41273-85. PMID 21979953 DOI: 10.1074/Jbc.M111.293266  0.433
2011 Ackerman ME, Lai JI, Pastan I, Wittrup KD. Exploiting bias in a non-immune human antibody library to predict antigenicity. Protein Engineering, Design & Selection : Peds. 24: 845-53. PMID 21908549 DOI: 10.1093/Protein/Gzr046  0.416
2011 Orcutt KD, Slusarczyk AL, Cieslewicz M, Ruiz-Yi B, Bhushan KR, Frangioni JV, Wittrup KD. Engineering an antibody with picomolar affinity to DOTA chelates of multiple radionuclides for pretargeted radioimmunotherapy and imaging. Nuclear Medicine and Biology. 38: 223-33. PMID 21315278 DOI: 10.1016/J.Nucmedbio.2010.08.013  0.437
2011 Pirie CM, Hackel BJ, Rosenblum MG, Wittrup KD. Convergent potency of internalized gelonin immunotoxins across varied cell lines, antigens, and targeting moieties. The Journal of Biological Chemistry. 286: 4165-72. PMID 21138845 DOI: 10.1074/Jbc.M110.186973  0.683
2011 Swers JS, Yeung YA, Wittrup KD. Integrated mimicry of B cell antibody mutagenesis using yeast homologous recombination. Molecular Biotechnology. 47: 57-69. PMID 20645027 DOI: 10.1007/S12033-010-9312-3  0.422
2011 Hackel BJ, Wittrup KD. Yeast Surface Display in Protein Engineering and Analysis Protein Engineering Handbook, Volume 1 & Volume 2. 2: 621-648. DOI: 10.1002/9783527634026.ch26  0.605
2010 Spangler JB, Neil JR, Abramovitch S, Yarden Y, White FM, Lauffenburger DA, Wittrup KD. Combination antibody treatment down-regulates epidermal growth factor receptor by inhibiting endosomal recycling. Proceedings of the National Academy of Sciences of the United States of America. 107: 13252-7. PMID 20616078 DOI: 10.1073/Pnas.0913476107  0.751
2010 Hackel BJ, Ackerman ME, Howland SW, Wittrup KD. Stability and CDR composition biases enrich binder functionality landscapes. Journal of Molecular Biology. 401: 84-96. PMID 20540948 DOI: 10.1016/J.Jmb.2010.06.004  0.667
2010 Higham EM, Shen CH, Wittrup KD, Chen J. Cutting edge: delay and reversal of T cell tolerance by intratumoral injection of antigen-loaded dendritic cells in an autochthonous tumor model. Journal of Immunology (Baltimore, Md. : 1950). 184: 5954-8. PMID 20427765 DOI: 10.4049/Jimmunol.1000265  0.318
2010 Higham EM, Wittrup KD, Chen J. Activation of tolerogenic dendritic cells in the tumor draining lymph nodes by CD8+ T cells engineered to express CD40 ligand. Journal of Immunology (Baltimore, Md. : 1950). 184: 3394-400. PMID 20200275 DOI: 10.4049/Jimmunol.0903111  0.329
2010 Hackel BJ, Wittrup KD. The full amino acid repertoire is superior to serine/tyrosine for selection of high affinity immunoglobulin G binders from the fibronectin scaffold. Protein Engineering, Design & Selection : Peds. 23: 211-9. PMID 20067921 DOI: 10.1093/Protein/Gzp083  0.674
2010 Orcutt KD, Ackerman ME, Cieslewicz M, Quiroz E, Slusarczyk AL, Frangioni JV, Wittrup KD. A modular IgG-scFv bispecific antibody topology. Protein Engineering, Design & Selection : Peds. 23: 221-8. PMID 20019028 DOI: 10.1093/Protein/Gzp077  0.415
2010 Orcutt KD, Frangioni JV, Wittrup KD. Abstract 4400: A novel bispecific antibody with high-affinity to DOTA-metal haptens for pretargeted radioimmunotherapy Cancer Research. 70: 4400-4400. DOI: 10.1158/1538-7445.Am10-4400  0.37
2009 Schmidt MM, Wittrup KD. A modeling analysis of the effects of molecular size and binding affinity on tumor targeting. Molecular Cancer Therapeutics. 8: 2861-71. PMID 19825804 DOI: 10.1158/1535-7163.Mct-09-0195  0.356
2009 Liu DV, Maier LM, Hafler DA, Wittrup KD. Engineered interleukin-2 antagonists for the inhibition of regulatory T cells. Journal of Immunotherapy (Hagerstown, Md. : 1997). 32: 887-94. PMID 19816193 DOI: 10.1097/Cji.0B013E3181B528Da  0.316
2009 Tasumi S, Velikovsky CA, Xu G, Gai SA, Wittrup KD, Flajnik MF, Mariuzza RA, Pancer Z. High-affinity lamprey VLRA and VLRB monoclonal antibodies. Proceedings of the National Academy of Sciences of the United States of America. 106: 12891-6. PMID 19625627 DOI: 10.1073/Pnas.0904443106  0.443
2009 Rakestraw JA, Sazinsky SL, Piatesi A, Antipov E, Wittrup KD. Directed evolution of a secretory leader for the improved expression of heterologous proteins and full-length antibodies in Saccharomyces cerevisiae. Biotechnology and Bioengineering. 103: 1192-201. PMID 19459139 DOI: 10.1002/Bit.22338  0.419
2009 Ackerman M, Levary D, Tobon G, Hackel B, Orcutt KD, Wittrup KD. Highly avid magnetic bead capture: an efficient selection method for de novo protein engineering utilizing yeast surface display. Biotechnology Progress. 25: 774-83. PMID 19363813 DOI: 10.1002/Btpr.174  0.684
2008 Sazinsky SL, Ott RG, Silver NW, Tidor B, Ravetch JV, Wittrup KD. Aglycosylated immunoglobulin G1 variants productively engage activating Fc receptors. Proceedings of the National Academy of Sciences of the United States of America. 105: 20167-72. PMID 19074274 DOI: 10.1073/Pnas.0809257105  0.411
2008 Bai A, Higham E, Eisen HN, Wittrup KD, Chen J. Rapid tolerization of virus-activated tumor-specific CD8+ T cells in prostate tumors of TRAMP mice. Proceedings of the National Academy of Sciences of the United States of America. 105: 13003-8. PMID 18723683 DOI: 10.1073/Pnas.0805599105  0.311
2008 Ackerman ME, Pawlowski D, Wittrup KD. Effect of antigen turnover rate and expression level on antibody penetration into tumor spheroids. Molecular Cancer Therapeutics. 7: 2233-40. PMID 18645032 DOI: 10.1158/1535-7163.Mct-08-0067  0.441
2008 Hackel BJ, Kapila A, Wittrup KD. Picomolar affinity fibronectin domains engineered utilizing loop length diversity, recursive mutagenesis, and loop shuffling. Journal of Molecular Biology. 381: 1238-52. PMID 18602401 DOI: 10.1016/J.Jmb.2008.06.051  0.66
2008 Thurber GM, Schmidt MM, Wittrup KD. Antibody tumor penetration: transport opposed by systemic and antigen-mediated clearance. Advanced Drug Delivery Reviews. 60: 1421-34. PMID 18541331 DOI: 10.1016/J.Addr.2008.04.012  0.7
2008 Thurber GM, Wittrup KD. Quantitative spatiotemporal analysis of antibody fragment diffusion and endocytic consumption in tumor spheroids. Cancer Research. 68: 3334-41. PMID 18451160 DOI: 10.1158/0008-5472.Can-07-3018  0.707
2008 Howarth M, Liu W, Puthenveetil S, Zheng Y, Marshall LF, Schmidt MM, Wittrup KD, Bawendi MG, Ting AY. Monovalent, reduced-size quantum dots for imaging receptors on living cells. Nature Methods. 5: 397-9. PMID 18425138 DOI: 10.1038/Nmeth.1206  0.326
2008 Schmidt MM, Thurber GM, Wittrup KD. Kinetics of anti-carcinoembryonic antigen antibody internalization: effects of affinity, bivalency, and stability. Cancer Immunology, Immunotherapy : Cii. 57: 1879-90. PMID 18408925 DOI: 10.1007/S00262-008-0518-1  0.717
2008 Ackerman ME, Chalouni C, Schmidt MM, Raman VV, Ritter G, Old LJ, Mellman I, Wittrup KD. A33 antigen displays persistent surface expression. Cancer Immunology, Immunotherapy : Cii. 57: 1017-27. PMID 18236042 DOI: 10.1007/S00262-007-0433-X  0.401
2008 Thurber GM, Schmidt MM, Wittrup KD. Factors determining antibody distribution in tumors. Trends in Pharmacological Sciences. 29: 57-61. PMID 18179828 DOI: 10.1016/J.Tips.2007.11.004  0.716
2007 Yeung YA, Finney AH, Koyrakh IA, Lebowitz MS, Ghanbari HA, Wands JR, Wittrup KD. Isolation and characterization of human antibodies targeting human aspartyl (asparaginyl) beta-hydroxylase. Human Antibodies. 16: 163-76. PMID 18334751  0.321
2007 Lipovsek D, Antipov E, Armstrong KA, Olsen MJ, Klibanov AM, Tidor B, Wittrup KD. Selection of horseradish peroxidase variants with enhanced enantioselectivity by yeast surface display. Chemistry & Biology. 14: 1176-85. PMID 17961829 DOI: 10.1016/J.Chembiol.2007.09.008  0.303
2007 Lippow SM, Wittrup KD, Tidor B. Computational design of antibody-affinity improvement beyond in vivo maturation. Nature Biotechnology. 25: 1171-6. PMID 17891135 DOI: 10.1038/Nbt1336  0.432
2007 Gai SA, Wittrup KD. Yeast surface display for protein engineering and characterization. Current Opinion in Structural Biology. 17: 467-73. PMID 17870469 DOI: 10.1016/J.Sbi.2007.08.012  0.392
2007 Thurber GM, Zajic SC, Wittrup KD. Theoretic criteria for antibody penetration into solid tumors and micrometastases. Journal of Nuclear Medicine : Official Publication, Society of Nuclear Medicine. 48: 995-9. PMID 17504872 DOI: 10.2967/Jnumed.106.037069  0.687
2007 Lipovsek D, Lippow SM, Hackel BJ, Gregson MW, Cheng P, Kapila A, Wittrup KD. Evolution of an interloop disulfide bond in high-affinity antibody mimics based on fibronectin type III domain and selected by yeast surface display: molecular convergence with single-domain camelid and shark antibodies. Journal of Molecular Biology. 368: 1024-41. PMID 17382960 DOI: 10.1016/J.Jmb.2007.02.029  0.702
2007 Krauland EM, Peelle BR, Wittrup KD, Belcher AM. Peptide tags for enhanced cellular and protein adhesion to single-crystalline sapphire. Biotechnology and Bioengineering. 97: 1009-20. PMID 17238208 DOI: 10.1002/Bit.21341  0.319
2006 Chao G, Lau WL, Hackel BJ, Sazinsky SL, Lippow SM, Wittrup KD. Isolating and engineering human antibodies using yeast surface display. Nature Protocols. 1: 755-68. PMID 17406305 DOI: 10.1038/Nprot.2006.94  0.7
2006 Swers JS, Widom A, Phan U, Springer TA, Wittrup KD. A high affinity human antibody antagonist of P-selectin mediated rolling. Biochemical and Biophysical Research Communications. 350: 508-13. PMID 17027652 DOI: 10.1016/J.Bbrc.2006.08.197  0.395
2006 Rakestraw JA, Baskaran AR, Wittrup KD. A flow cytometric assay for screening improved heterologous protein secretion in yeast. Biotechnology Progress. 22: 1200-8. PMID 16889399 DOI: 10.1021/Bp0600233  0.394
2006 Cochran JR, Kim YS, Lippow SM, Rao B, Wittrup KD. Improved mutants from directed evolution are biased to orthologous substitutions. Protein Engineering, Design & Selection : Peds. 19: 245-53. PMID 16740523 DOI: 10.1093/Protein/Gzl006  0.703
2006 Piatesi A, Howland SW, Rakestraw JA, Renner C, Robson N, Cebon J, Maraskovsky E, Ritter G, Old L, Wittrup KD. Directed evolution for improved secretion of cancer-testis antigen NY-ESO-1 from yeast. Protein Expression and Purification. 48: 232-42. PMID 16563796 DOI: 10.1016/J.Pep.2006.01.026  0.399
2006 Sivasubramanian A, Chao G, Pressler HM, Wittrup KD, Gray JJ. Structural model of the mAb 806-EGFR complex using computational docking followed by computational and experimental mutagenesis. Structure (London, England : 1993). 14: 401-14. PMID 16531225 DOI: 10.1016/J.Str.2005.11.022  0.371
2006 Kim YS, Bhandari R, Cochran JR, Kuriyan J, Wittrup KD. Directed evolution of the epidermal growth factor receptor extracellular domain for expression in yeast. Proteins. 62: 1026-35. PMID 16355407 DOI: 10.1002/Prot.20618  0.621
2006 Rakestraw A, Wittrup KD. Contrasting secretory processing of simultaneously expressed heterologous proteins in Saccharomyces cerevisiae. Biotechnology and Bioengineering. 93: 896-905. PMID 16333864 DOI: 10.1002/Bit.20780  0.339
2005 Rao BM, Driver I, Lauffenburger DA, Wittrup KD. High-affinity CD25-binding IL-2 mutants potently stimulate persistent T cell growth. Biochemistry. 44: 10696-701. PMID 16060678 DOI: 10.1021/Bi050436X  0.625
2005 Peelle BR, Krauland EM, Wittrup KD, Belcher AM. Design criteria for engineering inorganic material-specific peptides. Langmuir : the Acs Journal of Surfaces and Colloids. 21: 6929-33. PMID 16008405 DOI: 10.1021/La050261S  0.31
2005 Rao BM, Lauffenburger DA, Wittrup KD. Integrating cell-level kinetic modeling into the design of engineered protein therapeutics. Nature Biotechnology. 23: 191-4. PMID 15696150 DOI: 10.1038/Nbt1064  0.648
2004 Colby DW, Chu Y, Cassady JP, Duennwald M, Zazulak H, Webster JM, Messer A, Lindquist S, Ingram VM, Wittrup KD. Potent inhibition of huntingtin aggregation and cytotoxicity by a disulfide bond-free single-domain intracellular antibody. Proceedings of the National Academy of Sciences of the United States of America. 101: 17616-21. PMID 15598740 DOI: 10.1073/Pnas.0408134101  0.373
2004 Rao BM, Driver I, Lauffenburger DA, Wittrup KD. Interleukin 2 (IL-2) variants engineered for increased IL-2 receptor alpha-subunit affinity exhibit increased potency arising from a cell surface ligand reservoir effect. Molecular Pharmacology. 66: 864-9. PMID 15385640 DOI: 10.1124/Mol.66.4.864  0.638
2004 Colby DW, Garg P, Holden T, Chao G, Webster JM, Messer A, Ingram VM, Wittrup KD. Development of a human light chain variable domain (V(L)) intracellular antibody specific for the amino terminus of huntingtin via yeast surface display. Journal of Molecular Biology. 342: 901-12. PMID 15342245 DOI: 10.1016/J.Jmb.2004.07.054  0.425
2004 Chao G, Cochran JR, Wittrup KD. Fine epitope mapping of anti-epidermal growth factor receptor antibodies through random mutagenesis and yeast surface display. Journal of Molecular Biology. 342: 539-50. PMID 15327953 DOI: 10.1016/J.Jmb.2004.07.053  0.623
2004 Colby DW, Kellogg BA, Graff CP, Yeung YA, Swers JS, Wittrup KD. Engineering antibody affinity by yeast surface display. Methods in Enzymology. 388: 348-58. PMID 15289082 DOI: 10.1016/S0076-6879(04)88027-3  0.478
2004 Graff CP, Chester K, Begent R, Wittrup KD. Directed evolution of an anti-carcinoembryonic antigen scFv with a 4-day monovalent dissociation half-time at 37 degrees C. Protein Engineering, Design & Selection : Peds. 17: 293-304. PMID 15115853 DOI: 10.1093/Protein/Gzh038  0.426
2004 Cochran JR, Kim YS, Olsen MJ, Bhandari R, Wittrup KD. Domain-level antibody epitope mapping through yeast surface display of epidermal growth factor receptor fragments. Journal of Immunological Methods. 287: 147-58. PMID 15099763 DOI: 10.1016/J.Jim.2004.01.024  0.664
2004 Johns TG, Adams TE, Cochran JR, Hall NE, Hoyne PA, Olsen MJ, Kim YS, Rothacker J, Nice EC, Walker F, Ritter G, Jungbluth AA, Old LJ, Ward CW, Burgess AW, ... Wittrup KD, et al. Identification of the epitope for the epidermal growth factor receptor-specific monoclonal antibody 806 reveals that it preferentially recognizes an untethered form of the receptor. The Journal of Biological Chemistry. 279: 30375-84. PMID 15075331 DOI: 10.1074/Jbc.M401218200  0.628
2004 Swers JS, Kellogg BA, Wittrup KD. Shuffled antibody libraries created by in vivo homologous recombination and yeast surface display. Nucleic Acids Research. 32: e36. PMID 14978223 DOI: 10.1093/Nar/Gnh030  0.337
2004 Coughlan CM, Walker JL, Cochran JC, Wittrup KD, Brodsky JL. Degradation of mutated bovine pancreatic trypsin inhibitor in the yeast vacuole suggests post-endoplasmic reticulum protein quality control. The Journal of Biological Chemistry. 279: 15289-97. PMID 14744871 DOI: 10.1074/Jbc.M309673200  0.329
2004 Grovender EA, Kellogg B, Singh J, Blom D, Ploegh H, Wittrup KD, Langer RS, Ameer GA. Single-chain antibody fragment-based adsorbent for the extracorporeal removal of beta2-microglobulin. Kidney International. 65: 310-22. PMID 14675065 DOI: 10.1111/J.1523-1755.2004.00377.X  0.315
2003 Rao BM, Girvin AT, Ciardelli T, Lauffenburger DA, Wittrup KD. Interleukin-2 mutants with enhanced alpha-receptor subunit binding affinity. Protein Engineering. 16: 1081-7. PMID 14983090 DOI: 10.1093/Protein/Gzg111  0.635
2003 Orr BA, Carr LM, Wittrup KD, Roy EJ, Kranz DM. Rapid method for measuring ScFv thermal stability by yeast surface display. Biotechnology Progress. 19: 631-8. PMID 12675608 DOI: 10.1021/Bp0200797  0.34
2003 Graff CP, Wittrup KD. Theoretical analysis of antibody targeting of tumor spheroids: importance of dosage for penetration, and affinity for retention. Cancer Research. 63: 1288-96. PMID 12649189  0.347
2003 Feldhaus MJ, Siegel RW, Opresko LK, Coleman JR, Feldhaus JM, Yeung YA, Cochran JR, Heinzelman P, Colby D, Swers J, Graff C, Wiley HS, Wittrup KD. Flow-cytometric isolation of human antibodies from a nonimmune Saccharomyces cerevisiae surface display library. Nature Biotechnology. 21: 163-70. PMID 12536217 DOI: 10.1038/Nbt785  0.631
2002 Reardon KF, Lee KH, Wittrup KD, Hatzimanikatis V. Jay Bailey as mentor--the students' perspective. Biotechnology and Bioengineering. 79: 484-9. PMID 12209819 DOI: 10.1002/Bit.10402  0.703
2002 Yeung YA, Wittrup KD. Quantitative screening of yeast surface-displayed polypeptide libraries by magnetic bead capture Biotechnology Progress. 18: 212-220. PMID 11934287 DOI: 10.1021/Bp010186L  0.349
2001 Wittrup KD. Protein engineering by cell-surface display Current Opinion in Biotechnology. 12: 395-399. PMID 11551469 DOI: 10.1016/S0958-1669(00)00233-0  0.397
2001 Kieke MC, Sundberg E, Shusta EV, Mariuzza RA, Wittrup KD, Kranz DM. High affinity T cell receptors from yeast display libraries block T cell activation by superantigens. Journal of Molecular Biology. 307: 1305-15. PMID 11292343 DOI: 10.1006/Jmbi.2001.4560  0.648
2000 Boder ET, Midelfort KS, Wittrup KD. Directed evolution of antibody fragments with monovalent femtomolar antigen-binding affinity Proceedings of the National Academy of Sciences of the United States of America. 97: 10701-10705. PMID 10984501 DOI: 10.1073/Pnas.170297297  0.454
2000 Shusta EV, Holler PD, Kieke MC, Kranz DM, Wittrup KD. Directed evolution of a stable scaffold for T-cell receptor engineering. Nature Biotechnology. 18: 754-9. PMID 10888844 DOI: 10.1038/77325  0.669
2000 Holler PD, Holman PO, Shusta EV, O'Herrin S, Wittrup KD, Kranz DM. In vitro evolution of a T cell receptor with high affinity for peptide/MHC. Proceedings of the National Academy of Sciences of the United States of America. 97: 5387-92. PMID 10779548 DOI: 10.1073/Pnas.080078297  0.637
2000 Bannister SJ, Wittrup KD. Glutathione excretion in response to heterologous protein secretion in Saccharomyces cerevisiae. Biotechnology and Bioengineering. 68: 389-95. PMID 10745207 DOI: 10.1002/(Sici)1097-0290(20000520)68:4<389::Aid-Bit4>3.0.Co;2-N  0.726
2000 VanAntwerp JJ, Wittrup KD. Fine affinity discrimination by yeast surface display and flow cytometry Biotechnology Progress. 16: 31-37. PMID 10662486 DOI: 10.1021/bp990133s  0.319
1999 Wittrup KD. Phage on display Trends in Biotechnology. 17: 423-424. PMID 10610089 DOI: 10.1016/S0167-7799(99)01349-9  0.309
1999 Shusta EV, Kieke MC, Parke E, Kranz DM, Wittrup KD. Yeast polypeptide fusion surface display levels predict thermal stability and soluble secretion efficiency. Journal of Molecular Biology. 292: 949-56. PMID 10512694 DOI: 10.1006/Jmbi.1999.3130  0.63
1999 Kieke MC, Shusta EV, Boder ET, Teyton L, Wittrup KD, Kranz DM. Selection of functional T cell receptor mutants from a yeast surface-display library. Proceedings of the National Academy of Sciences of the United States of America. 96: 5651-6. PMID 10318939 DOI: 10.1073/Pnas.96.10.5651  0.673
1999 Shusta EV, Vanantwerp J, Wittrup KD. Biosynthetic polypeptide libraries Current Opinion in Biotechnology. 10: 117-122. PMID 10209135 DOI: 10.1016/S0958-1669(99)80020-2  0.537
1998 VanAntwerp JJ, Wittrup KD. Thermodynamic characterization of affinity maturation: The D1.3 antibody and a higher-affinity mutant Journal of Molecular Recognition. 11: 10-13. PMID 10076798 DOI: 10.1002/(Sici)1099-1352(199812)11:1/6<10::Aid-Jmr381>3.0.Co;2-H  0.395
1998 Cho BK, Kieke MC, Boder ET, Wittrup KD, Kranz DM. A yeast surface display system for the discovery of ligands that trigger cell activation. Journal of Immunological Methods. 220: 179-88. PMID 9839939 DOI: 10.1016/S0022-1759(98)00158-6  0.366
1998 Kowalski JM, Kelly RM, Konisky J, Clark DS, Wittrup KD. Purification and functional characterization of a chaperone from Methanococcus jannaschii Systematic and Applied Microbiology. 21: 173-178. PMID 9704106 DOI: 10.1016/S0723-2020(98)80021-0  0.493
1998 Shusta EV, Raines RT, Plückthun A, Wittrup KD. Increasing the secretory capacity of Saccharomyces cerevisiae for production of single-chain antibody fragments Nature Biotechnology. 16: 773-777. PMID 9702778 DOI: 10.1038/nbt0898-773  0.601
1998 Kowalski JM, Parekh RN, Mao J, Wittrup KD. Protein folding stability can determine the efficiency of escape from endoplasmic reticulum quality control. The Journal of Biological Chemistry. 273: 19453-8. PMID 9677365 DOI: 10.1074/Jbc.273.31.19453  0.314
1997 Kieke MC, Cho BK, Boder ET, Kranz DM, Wittrup KD. Isolation of anti-T cell receptor scFv mutants by yeast surface display. Protein Engineering. 10: 1303-10. PMID 9514119 DOI: 10.1093/Protein/10.11.1303  0.345
1997 Boder ET, Wittrup KD. Yeast surface display for screening combinatorial polypeptide libraries Nature Biotechnology. 15: 553-557. PMID 9181578  0.369
1996 Robinson AS, Bockhaus JA, Voegler AC, Wittrup KD. Reduction of BiP levels decreases heterologous protein secretion in Saccharomyces cerevisiae Journal of Biological Chemistry. 271: 10017-10022. PMID 8626555 DOI: 10.1074/Jbc.271.17.10017  0.566
1995 Robinson AS, Wittrup KD. Constitutive overexpression of secreted heterologous proteins decreases extractable BiP and protein disulfide isomerase levels in Saccharomyces cerevisiae Biotechnology Progress. 11: 171-177. PMID 7536423 DOI: 10.1021/Bp00032A009  0.603
1994 Wittrup KD, Robinson AS, Parekh RN, Forrester KJ. Existence of an optimum expression level for secretion of foreign proteins in yeast. Annals of the New York Academy of Sciences. 745: 321-30. PMID 7530433  0.536
1994 Robinson AS, Hines V, Wittrup KD. Protein disulfide isomerase overexpression increases secretion of foreign proteins in Saccharomyces cerevisiae Nature Biotechnology. 12: 381-384. DOI: 10.1038/Nbt0494-381  0.595
1993 Shaw MR, Schiek R, Wittrup KD. Stochastic simulation of 2μ multicopy plasmid amplification in yeast Biotechnology Progress. 9: 160-165. PMID 7763592 DOI: 10.1021/Bp00020A007  0.311
1991 Wittrup KD, Bailey JE. Comments on a segregated model of recombinant cultures: authors' reply. Biotechnology and Bioengineering. 38: 1364-5. PMID 18600738 DOI: 10.1002/Bit.260381114  0.326
1990 Wittrup KD, Bailey JE, Ratzkin B, Patel A. Propagation of an amplifiable recombinant plasmid in Saccharomyces cerevisiae: flow cytometry studies and segregated modeling. Biotechnology and Bioengineering. 35: 565-77. PMID 18592552 DOI: 10.1002/Bit.260350604  0.484
1990 Wittrup KD, Bailey JE. Mathematical modeling of a single-cell enzyme assay. Biotechnology and Bioengineering. 35: 525-32. PMID 18592546 DOI: 10.1002/Bit.260350511  0.454
1989 Meilhoc E, Wittrup KD, Bailey JE. Application of flow cytometric measurement of surface IgG in kinetic analysis of monoclonal antibody synthesis and secretion by murine hybridoma cells. Journal of Immunological Methods. 121: 167-74. PMID 2760464 DOI: 10.1016/0022-1759(89)90157-9  0.557
1989 Budd ME, Wittrup KD, Bailey JE, Campbell JL. DNA polymerase I is required for premeiotic DNA replication and sporulation but not for X-ray repair in Saccharomyces cerevisiae. Molecular and Cellular Biology. 9: 365-76. PMID 2651896 DOI: 10.1128/Mcb.9.2.365  0.32
1988 Wittrup KD, Bailey JE. A segregated model of recombinant multicopy plasmid propagation. Biotechnology and Bioengineering. 31: 304-10. PMID 18584609 DOI: 10.1002/Bit.260310405  0.386
1988 Wittrup KD, Bailey JE. A single-cell assay of beta-galactosidase activity in Saccharomyces cerevisiae. Cytometry. 9: 394-404. PMID 3135986 DOI: 10.1002/Cyto.990090418  0.377
1988 Wittrup KD, Bailey JE. A mathematical model of recombinational amplification of the 2 mu plasmid in the yeast Saccharomyces cerevisiae. Journal of Theoretical Biology. 130: 481-92. PMID 3054338 DOI: 10.1016/S0022-5193(88)80212-1  0.368
1988 Wittrup KD, Mann MB, Fenton DM, Tsai LB, Bailey JE. Single–Cell Light Scatter as a Probe of Refractile Body Formation in Recombinant Escherichia Coli Nature Biotechnology. 6: 423-426. DOI: 10.1038/Nbt0488-423  0.353
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