Doug A. Lauffenburger - Publications

Affiliations: 
1979-1990 University of Pennsylvania, Philadelphia, PA, United States 
 1990-1994 University of Illinois, Urbana-Champaign, Urbana-Champaign, IL 
 1995- Bioengineering Massachusetts Institute of Technology, Cambridge, MA, United States 
Area:
Molecular Cell Bioengineering
Website:
http://web.mit.edu/dallab/people/index.html

435 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2021 Kaplonek P, Wang C, Bartsch Y, Fischinger S, Gorman MJ, Bowman K, Kang J, Dayal D, Martin P, Nowak R, Hsieh CL, Feldman J, Julg B, Nilles EJ, Musk ER, ... ... Lauffenburger DA, et al. Early cross-coronavirus reactive signatures of protective humoral immunity against COVID-19. Biorxiv : the Preprint Server For Biology. PMID 34013263 DOI: 10.1101/2021.05.11.443609  0.32
2021 Li R, Ng TSC, Wang SJ, Prytyskach M, Rodell CB, Mikula H, Kohler RH, Garlin MA, Lauffenburger DA, Parangi S, Dinulescu DM, Bardeesy N, Weissleder R, Miller MA. Therapeutically reprogrammed nutrient signalling enhances nanoparticulate albumin bound drug uptake and efficacy in KRAS-mutant cancer. Nature Nanotechnology. PMID 33958764 DOI: 10.1038/s41565-021-00897-1  0.44
2021 Atyeo C, DeRiso EA, Davis C, Bordt EA, DeGuzman RM, Shook LL, Yonker LM, Fasano A, Akinwunmi B, Lauffenburger DA, Elovitz MA, Gray KJ, Edlow AG, Alter G. COVID-19 mRNA vaccines drive differential Fc-functional profiles in pregnant, lactating, and non-pregnant women. Biorxiv : the Preprint Server For Biology. PMID 33851165 DOI: 10.1101/2021.04.04.438404  0.32
2021 Bordt EA, Shook LL, Atyeo C, Pullen KM, De Guzman RM, Meinsohn MC, Chauvin M, Fischinger S, Yockey LJ, James K, Lima R, Yonker LM, Fasano A, Brigida S, Bebell LM, ... ... Lauffenburger D, et al. Sexually dimorphic placental responses to maternal SARS-CoV-2 infection. Biorxiv : the Preprint Server For Biology. PMID 33821279 DOI: 10.1101/2021.03.29.437516  0.32
2021 Herman JD, Wang C, Loos C, Yoon H, Rivera J, Dieterle ME, Haslwanter D, Jangra RK, Bortz RH, Bar KJ, Julg B, Chandran K, Lauffenburger D, Pirofski LA, Alter G. Functional Antibodies in COVID-19 Convalescent Plasma. Medrxiv : the Preprint Server For Health Sciences. PMID 33758875 DOI: 10.1101/2021.03.08.21253157  0.32
2021 Chen WLK, Suter E, Miyazaki H, Velazquez J, Lauffenburger DA, Griffith LG, Carrier RL. Synergistic Action of Diclofenac with Endotoxin-Mediated Inflammation Exacerbates Intestinal Injury . Acs Infectious Diseases. PMID 33745271 DOI: 10.1021/acsinfecdis.0c00762  0.92
2021 Stephenson KE, Le Gars M, Sadoff J, de Groot AM, Heerwegh D, Truyers C, Atyeo C, Loos C, Chandrashekar A, McMahan K, Tostanoski LH, Yu J, Gebre MS, Jacob-Dolan C, Li Z, ... ... Lauffenburger DA, et al. Immunogenicity of the Ad26.COV2.S Vaccine for COVID-19. Jama. PMID 33704352 DOI: 10.1001/jama.2021.3645  0.32
2021 Bartsch YC, Loos C, Rossignol E, Fajnzylber JM, Yuan D, Avihingsanon A, Ubolyam S, Jupimai T, Hirschel B, Ananworanich J, Lauffenburger DA, Li JZ, Alter G, Julg B. Viral Rebound Kinetics Correlate with Distinct HIV Antibody Features. Mbio. 12. PMID 33688003 DOI: 10.1128/mBio.00170-21  0.32
2021 Yu KK, Fischinger S, Smith MT, Atyeo C, Cizmeci D, Wolf CR, Layton ED, Logue JK, Aguilar MS, Shuey K, Loos C, Yu J, Franko NM, Choi RY, Wald A, ... ... Lauffenburger D, et al. Comorbid illnesses are associated with altered adaptive immune responses to SARS-CoV-2. Jci Insight. PMID 33621211 DOI: 10.1172/jci.insight.146242  0.32
2021 Alter G, Gorman M, Patel N, Guebre-Xabier M, Zhu A, Atyeo C, Pullen K, Loos C, Goez-Gazi Y, Carrion R, Tian JH, Yuan D, Bowman K, Zhou B, Maciejewski S, ... ... Lauffenburger D, et al. Collaboration between the Fab and Fc contribute to maximal protection against SARS-CoV-2 following NVX-CoV2373 subunit vaccine with Matrix-M™ vaccination. Research Square. PMID 33619473 DOI: 10.21203/rs.3.rs-200342/v1  0.32
2021 Bartsch YC, Wang C, Zohar T, Fischinger S, Atyeo C, Burke JS, Kang J, Edlow AG, Fasano A, Baden LR, Nilles EJ, Woolley AE, Karlson EW, Hopke AR, Irimia D, ... ... Lauffenburger DA, et al. Humoral signatures of protective and pathological SARS-CoV-2 infection in children. Nature Medicine. PMID 33589825 DOI: 10.1038/s41591-021-01263-3  0.32
2021 Bartsch YC, Fischinger S, Siddiqui SM, Chen Z, Yu J, Gebre M, Atyeo C, Gorman MJ, Zhu AL, Kang J, Burke JS, Slein M, Gluck MJ, Beger S, Hu Y, ... ... Lauffenburger DA, et al. Discrete SARS-CoV-2 antibody titers track with functional humoral stability. Nature Communications. 12: 1018. PMID 33589636 DOI: 10.1038/s41467-021-21336-8  0.32
2021 Gorman MJ, Patel N, Guebre-Xabier M, Zhu A, Atyeo C, Pullen KM, Loos C, Goez-Gazi Y, Carrion R, Tian JH, Yaun D, Bowman K, Zhou B, Maciejewski S, McGrath ME, ... ... Lauffenburger D, et al. Collaboration between the Fab and Fc contribute to maximal protection against SARS-CoV-2 in nonhuman primates following NVX-CoV2373 subunit vaccine with Matrix-M™ vaccination. Biorxiv : the Preprint Server For Biology. PMID 33564763 DOI: 10.1101/2021.02.05.429759  0.32
2021 Trapecar M, Wogram E, Svoboda D, Communal C, Omer A, Lungjangwa T, Sphabmixay P, Velazquez J, Schneider K, Wright CW, Mildrum S, Hendricks A, Levine S, Muffat J, Lee MJ, ... Lauffenburger DA, et al. Human physiomimetic model integrating microphysiological systems of the gut, liver, and brain for studies of neurodegenerative diseases. Science Advances. 7. PMID 33514545 DOI: 10.1126/sciadv.abd1707  0.92
2021 Mercado NB, Zahn R, Wegmann F, Loos C, Chandrashekar A, Yu J, Liu J, Peter L, McMahan K, Tostanoski LH, He X, Martinez DR, Rutten L, Bos R, van Manen D, ... ... Lauffenburger DA, et al. Publisher Correction: Single-shot Ad26 vaccine protects against SARS-CoV-2 in rhesus macaques. Nature. PMID 33469218 DOI: 10.1038/s41586-020-03100-y  0.32
2020 Atyeo C, Pullen KM, Bordt EA, Fischinger S, Burke J, Michell A, Slein MD, Loos C, Shook LL, Boatin AA, Yockey LJ, Pepin D, Meinsohn MC, Nguyen NMP, Chauvin M, ... ... Lauffenburger D, et al. Compromised SARS-CoV-2-specific placental antibody transfer. Cell. PMID 33476549 DOI: 10.1016/j.cell.2020.12.027  0.32
2020 Offersen R, Yu WH, Scully EP, Julg B, Euler Z, Sadanand S, Garcia-Dominguez D, Zheng L, Rasmussen TA, Jennewein MF, Linde C, Sassic J, Lofano G, Vigano S, Stephenson KE, ... ... Lauffenburger D, et al. HIV Antibody Fc N-Linked Glycosylation Is Associated with Viral Rebound. Cell Reports. 33: 108502. PMID 33326789 DOI: 10.1016/j.celrep.2020.108502  0.32
2020 McMahan K, Yu J, Mercado NB, Loos C, Tostanoski LH, Chandrashekar A, Liu J, Peter L, Atyeo C, Zhu A, Bondzie EA, Dagotto G, Gebre MS, Jacob-Dolan C, Li Z, ... ... Lauffenburger DA, et al. Correlates of protection against SARS-CoV-2 in rhesus macaques. Nature. PMID 33276369 DOI: 10.1038/s41586-020-03041-6  0.32
2020 Yu KKQ, Fischinger S, Smith MT, Atyeo C, Cizmeci D, Wolf CR, Layton ED, Logue JK, Aguilar MS, Shuey K, Loos C, Yu J, Franko N, Choi RY, Wald A, ... ... Lauffenburger D, et al. T cell and antibody functional correlates of severe COVID-19. Medrxiv : the Preprint Server For Health Sciences. PMID 33269369 DOI: 10.1101/2020.11.25.20235150  0.32
2020 Zohar T, Loos C, Fischinger S, Atyeo C, Wang C, Slein MD, Burke J, Yu J, Feldman J, Hauser BM, Caradonna T, Schmidt AG, Cai Y, Streeck H, Ryan ET, ... ... Lauffenburger DA, et al. Compromised Humoral Functional Evolution Tracks with SARS-CoV-2 Mortality. Cell. PMID 33207184 DOI: 10.1016/j.cell.2020.10.052  0.32
2020 Nilles EJ, Siddiqui SM, Fischinger S, Bartsch YC, de Saint Aubin M, Zhou G, Gluck M, Berger S, Rhee J, Petersen E, Mormann B, Loesche M, Chen Z, Yu J, Gebre M, ... ... Lauffenburger DA, et al. Epidemiological and immunological features of obesity and SARS-CoV-2. Medrxiv : the Preprint Server For Health Sciences. PMID 33200139 DOI: 10.1101/2020.11.11.20229724  0.32
2020 Chen Y, Zuiani A, Fischinger S, Mullur J, Atyeo C, Travers M, Lelis FJN, Pullen KM, Martin H, Tong P, Gautam A, Habibi S, Bensko J, Gakpo D, Feldman J, ... ... Lauffenburger DA, et al. Quick COVID-19 Healers Sustain Anti-SARS-CoV-2 Antibody Production. Cell. PMID 33171099 DOI: 10.1016/j.cell.2020.10.051  0.32
2020 Gerosa L, Chidley C, Fröhlich F, Sanchez G, Lim SK, Muhlich J, Chen JY, Vallabhaneni S, Baker GJ, Schapiro D, Atanasova MI, Chylek LA, Shi T, Yi L, Nicora CD, ... ... Lauffenburger DA, et al. Receptor-Driven ERK Pulses Reconfigure MAPK Signaling and Enable Persistence of Drug-Adapted BRAF-Mutant Melanoma Cells. Cell Systems. PMID 33113355 DOI: 10.1016/j.cels.2020.10.002  0.6
2020 Das J, Devadhasan A, Linde C, Broge T, Sassic J, Mangano M, O'Keefe S, Suscovich T, Streeck H, Irrinki A, Pohlmeyer C, Min-Oo G, Lin S, Weiner JA, Cihlar T, ... ... Lauffenburger DA, et al. Mining for humoral correlates of HIV control and latent reservoir size. Plos Pathogens. 16: e1008868. PMID 33048992 DOI: 10.1371/journal.ppat.1008868  0.32
2020 Tostanoski LH, Wegmann F, Martinot AJ, Loos C, McMahan K, Mercado NB, Yu J, Chan CN, Bondoc S, Starke CE, Nekorchuk M, Busman-Sahay K, Piedra-Mora C, Wrijil LM, Ducat S, ... ... Lauffenburger DA, et al. Ad26 vaccine protects against SARS-CoV-2 severe clinical disease in hamsters. Nature Medicine. PMID 32884153 DOI: 10.1038/S41591-020-1070-6  0.32
2020 Loos C, Atyeo C, Fischinger S, Burke J, Slein MD, Streeck H, Lauffenburger D, Ryan ET, Charles RC, Alter G. Evolution of Early SARS-CoV-2 and Cross-Coronavirus Immunity. Msphere. 5. PMID 32878931 DOI: 10.1128/mSphere.00622-20  0.32
2020 Atyeo C, Fischinger S, Zohar T, Slein MD, Burke J, Loos C, McCulloch DJ, Newman KL, Wolf C, Yu J, Shuey K, Feldman J, Hauser BM, Caradonna T, Schmidt AG, ... ... Lauffenburger D, et al. Distinct Early Serological Signatures Track with SARS-CoV-2 Survival. Immunity. PMID 32783920 DOI: 10.1016/J.Immuni.2020.07.020  0.32
2020 Roy V, Fischinger S, Atyeo C, Slein M, Loos C, Balazs A, Luedemann C, Astudillo MG, Yang D, Wesemann D, Charles R, Lafrate AJ, Feldman J, Hauser B, Caradonna T, ... ... Lauffenburger D, et al. SARS-CoV-2-specific ELISA development. Journal of Immunological Methods. 112832. PMID 32780998 DOI: 10.1016/J.Jim.2020.112832  0.32
2020 Loos C, Lauffenburger DA, Alter G. Dissecting the antibody-OME: past, present, and future. Current Opinion in Immunology. 65: 89-96. PMID 32755751 DOI: 10.1016/J.Coi.2020.06.003  0.32
2020 Brubaker DK, Kumar MP, Chiswick EL, Gregg C, Starchenko A, Vega PN, Southard-Smith AN, Simmons AJ, Scoville EA, Coburn LA, Wilson KT, Lau KS, Lauffenburger DA. An interspecies translation model implicates integrin signaling in infliximab-resistant inflammatory bowel disease. Science Signaling. 13. PMID 32753478 DOI: 10.1126/Scisignal.Aay3258  0.36
2020 Mercado NB, Zahn R, Wegmann F, Loos C, Chandrashekar A, Yu J, Liu J, Peter L, McMahan K, Tostanoski LH, He X, Martinez DR, Rutten L, Bos R, van Manen D, ... ... Lauffenburger DA, et al. Single-shot Ad26 vaccine protects against SARS-CoV-2 in rhesus macaques. Nature. PMID 32731257 DOI: 10.1038/S41586-020-2607-Z  0.32
2020 Suscovich TJ, Fallon JK, Das J, Demas AR, Crain J, Linde CH, Michell A, Natarajan H, Arevalo C, Broge T, Linnekin T, Kulkarni V, Lu R, Slein MD, Luedemann C, ... ... Lauffenburger DA, et al. Mapping functional humoral correlates of protection against malaria challenge following RTS,S/AS01 vaccination. Science Translational Medicine. 12. PMID 32718991 DOI: 10.1126/Scitranslmed.Abb4757  0.32
2020 Luthria G, Li R, Wang S, Prytyskach M, Kohler RH, Lauffenburger DA, Mitchison TJ, Weissleder R, Miller MA. In vivo microscopy reveals macrophage polarization locally promotes coherent microtubule dynamics in migrating cancer cells. Nature Communications. 11: 3521. PMID 32665556 DOI: 10.1038/S41467-020-17147-Y  0.44
2020 Wang SJ, Li R, Ng TSC, Luthria G, Oudin MJ, Prytyskach M, Kohler RH, Weissleder R, Lauffenburger DA, Miller MA. Efficient blockade of locally reciprocated tumor-macrophage signaling using a TAM-avid nanotherapy. Science Advances. 6: eaaz8521. PMID 32494745 DOI: 10.1126/Sciadv.Aaz8521  0.44
2020 Proctor EA, Dineen SM, Van Nostrand SC, Kuhn MK, Barrett CD, Brubaker DK, Yaffe MB, Lauffenburger DA, Leon LR. Coagulopathy signature precedes and predicts severity of end-organ heat stroke pathology in a mouse model. Journal of Thrombosis and Haemostasis : Jth. PMID 32367690 DOI: 10.1111/Jth.14875  0.32
2020 Holland CH, Tanevski J, Perales-Patón J, Gleixner J, Kumar MP, Mereu E, Joughin BA, Stegle O, Lauffenburger DA, Heyn H, Szalai B, Saez-Rodriguez J. Robustness and applicability of transcription factor and pathway analysis tools on single-cell RNA-seq data. Genome Biology. 21: 36. PMID 32051003 DOI: 10.1186/S13059-020-1949-Z  0.36
2020 Kester JC, Brubaker DK, Velazquez J, Wright C, Lauffenburger DA, Griffith LG. -associated antibiotics alter human mucosal barrier functions by microbiome-independent mechanisms. Antimicrobial Agents and Chemotherapy. PMID 31988098 DOI: 10.1128/Aac.01404-19  0.92
2019 Strasser SD, Ghazi PC, Starchenko A, Boukhali M, Edwards A, Suarez-Lopez L, Lyons J, Changelian PS, Monahan JB, Jacobsen J, Brubaker DK, Joughin BA, Yaffe MB, Haas W, Lauffenburger DA, et al. Substrate-based kinase activity inference identifies MK2 as driver of colitis. Integrative Biology : Quantitative Biosciences From Nano to Macro. PMID 31617572 DOI: 10.1093/Intbio/Zyz025  0.32
2019 Yu WH, Su D, Torabi J, Fennessey CM, Shiakolas A, Lynch R, Chun TW, Doria-Rose N, Alter G, Seaman MS, Keele BF, Lauffenburger DA, Julg B. Predicting the broadly neutralizing antibody susceptibility of the HIV reservoir. Jci Insight. 4. PMID 31484826 DOI: 10.1172/Jci.Insight.130153  0.32
2019 Dalin S, Sullivan MR, Lau AN, Grauman-Boss B, Mueller HS, Kreidl E, Fenoglio S, Luengo A, Lees JA, Vander Heiden MG, Lauffenburger DA, Hemann MT. Deoxycytidine Release from Pancreatic Stellate Cells Promotes Gemcitabine Resistance. Cancer Research. PMID 31484670 DOI: 10.1158/0008-5472.Can-19-0960  0.76
2019 Ahrens CC, Chiswick EL, Ravindra KC, Miller MA, Ramseier J, Isaacson KB, Lauffenburger DA, Griffith LG. Development and Application of the Metalloprotease Activity Multi-plexed Bead-based Immunoassay (MAMBI). Biochemistry. PMID 31474112 DOI: 10.1021/Acs.Biochem.9B00584  0.92
2019 Kinney MA, Vo LT, Frame JM, Barragan J, Conway AJ, Li S, Wong KK, Collins JJ, Cahan P, North TE, Lauffenburger DA, Daley GQ. Author Correction: A systems biology pipeline identifies regulatory networks for stem cell engineering. Nature Biotechnology. PMID 31312048 DOI: 10.1038/S41587-019-0212-1  0.6
2019 Patterson JC, Joughin BA, Prota AE, Mühlethaler T, Jonas OH, Whitman MA, Varmeh S, Chen S, Balk SP, Steinmetz MO, Lauffenburger DA, Yaffe MB. VISAGE Reveals a Targetable Mitotic Spindle Vulnerability in Cancer Cells. Cell Systems. PMID 31302152 DOI: 10.1016/J.Cels.2019.05.009  0.32
2019 Kinney MA, Vo LT, Frame JM, Barragan J, Conway AJ, Li S, Wong KK, Collins JJ, Cahan P, North TE, Lauffenburger DA, Daley GQ. A systems biology pipeline identifies regulatory networks for stem cell engineering. Nature Biotechnology. 37: 810-818. PMID 31267104 DOI: 10.1038/S41587-019-0159-2  0.6
2019 Lu LL, Smith MT, Yu KKQ, Luedemann C, Suscovich TJ, Grace PS, Cain A, Yu WH, McKitrick TR, Lauffenburger D, Cummings RD, Mayanja-Kizza H, Hawn TR, Boom WH, Stein CM, et al. Publisher Correction: IFN-γ-independent immune markers of Mycobacterium tuberculosis exposure. Nature Medicine. PMID 31222179 DOI: 10.1038/S41591-019-0519-Y  0.32
2019 Lu LL, Smith MT, Yu KKQ, Luedemann C, Suscovich TJ, Grace PS, Cain A, Yu WH, McKitrick TR, Lauffenburger D, Cummings RD, Mayanja-Kizza H, Hawn TR, Boom WH, Stein CM, et al. IFN-γ-independent immune markers of Mycobacterium tuberculosis exposure. Nature Medicine. PMID 31110348 DOI: 10.1038/S41591-019-0441-3  0.32
2019 Patterson JC, Joughin BA, van de Kooij B, Lim DC, Lauffenburger DA, Yaffe MB. ROS and Oxidative Stress Are Elevated in Mitosis during Asynchronous Cell Cycle Progression and Are Exacerbated by Mitotic Arrest. Cell Systems. PMID 30797774 DOI: 10.1016/J.Cels.2019.01.005  0.32
2019 Rohani N, Hao L, Alexis MS, Joughin BA, Krismer K, Moufarrej MN, Soltis AR, Lauffenburger DA, Yaffe MB, Burge CB, Bhatia SN, Gertler FB. Acidification of tumor at stromal boundaries drives transcriptome alterations associated with aggressive phenotypes. Cancer Research. PMID 30755444 DOI: 10.1158/0008-5472.Can-18-1604  0.32
2018 Goetghebuer T, Smolen KK, Adler C, Das J, McBride T, Smits G, Lecomte S, Haelterman E, Barlow P, Piedra PA, van der Klis F, Kollmann TR, Lauffenburger DA, Alter G, Levy J, et al. Reply to Slogrove, et al. Clinical Infectious Diseases : An Official Publication of the Infectious Diseases Society of America. PMID 30535371 DOI: 10.1093/Cid/Ciy1058  0.32
2018 Kumar MP, Du J, Lagoudas G, Jiao Y, Sawyer A, Drummond DC, Lauffenburger DA, Raue A. Analysis of Single-Cell RNA-Seq Identifies Cell-Cell Communication Associated with Tumor Characteristics. Cell Reports. 25: 1458-1468.e4. PMID 30404002 DOI: 10.1016/J.Celrep.2018.10.047  0.36
2018 Goetghebuer T, Smolen KK, Adler C, Das J, McBride T, Smits G, Lecomte S, Haelterman E, Barlow P, Piedra PA, van der Klis F, Kollmann TR, Lauffenburger DA, Alter G, Levy J, et al. Initiation of anti-retroviral therapy before pregnancy reduces the risk of infection-related hospitalization in HIV-exposed uninfected infants born in a high-income country. Clinical Infectious Diseases : An Official Publication of the Infectious Diseases Society of America. PMID 30215689 DOI: 10.1093/Cid/Ciy673  0.32
2018 Ackerman ME, Das J, Pittala S, Broge T, Linde C, Suscovich TJ, Brown EP, Bradley T, Natarajan H, Lin S, Sassic JK, O'Keefe S, Mehta N, Goodman D, Sips M, ... ... Lauffenburger DA, et al. Route of immunization defines multiple mechanisms of vaccine-mediated protection against SIV. Nature Medicine. PMID 30177821 DOI: 10.1038/S41591-018-0161-0  0.32
2018 Lofano G, Gorman MJ, Yousif AS, Yu WH, Fox JM, Dugast AS, Ackerman ME, Suscovich TJ, Weiner J, Barouch D, Streeck H, Little S, Smith D, Richman D, Lauffenburger D, et al. Antigen-specific antibody Fc glycosylation enhances humoral immunity via the recruitment of complement. Science Immunology. 3. PMID 30120121 DOI: 10.1126/Sciimmunol.Aat7796  0.32
2018 Gunn BM, Yu WH, Karim MM, Brannan JM, Herbert AS, Wec AZ, Halfmann PJ, Fusco ML, Schendel SL, Gangavarapu K, Krause T, Qiu X, He S, Das J, Suscovich TJ, ... ... Lauffenburger D, et al. A Role for Fc Function in Therapeutic Monoclonal Antibody-Mediated Protection against Ebola Virus. Cell Host & Microbe. 24: 221-233.e5. PMID 30092199 DOI: 10.1016/J.Chom.2018.07.009  0.32
2018 Yoneyama T, Gorry M, Sobo-Vujanovic A, Lin Y, Vujanovic L, Gaither-Davis A, Moss ML, Miller MA, Griffith LG, Lauffenburger DA, Stabile LP, Herman J, Vujanovic NL. ADAM10 Sheddase Activity is a Potential Lung-Cancer Biomarker. Journal of Cancer. 9: 2559-2570. PMID 30026855 DOI: 10.7150/Jca.24601  0.92
2018 Yu WH, Zhao P, Draghi M, Arevalo C, Karsten CB, Suscovich TJ, Gunn B, Streeck H, Brass AL, Tiemeyer M, Seaman M, Mascola JR, Wells L, Lauffenburger DA, Alter G. Exploiting glycan topography for computational design of Env glycoprotein antigenicity. Plos Computational Biology. 14: e1006093. PMID 29677181 DOI: 10.1371/Journal.Pcbi.1006093  0.32
2018 Edington CD, Chen WLK, Geishecker E, Kassis T, Soenksen LR, Bhushan BM, Freake D, Kirschner J, Maass C, Tsamandouras N, Valdez J, Cook CD, Parent T, Snyder S, Yu J, ... ... Lauffenburger DA, et al. Interconnected Microphysiological Systems for Quantitative Biology and Pharmacology Studies. Scientific Reports. 8: 4530. PMID 29540740 DOI: 10.1038/S41598-018-22749-0  0.92
2018 Jones DS, Jenney AP, Joughin BA, Sorger PK, Lauffenburger DA. Inflammatory but not mitogenic contexts prime synovial fibroblasts for compensatory signaling responses to p38 inhibition. Science Signaling. 11. PMID 29511118 DOI: 10.1126/Scisignal.Aal1601  0.4
2018 Clark AM, Kumar M, Wheeler S, Young C, Venkataramanan R, Stolz D, Griffith L, Lauffenburger DA, Wells A. A model of dormant-emergent metastatic breast cancer progression enabling exploration of biomarker signatures. Molecular & Cellular Proteomics : McP. PMID 29353230 DOI: 10.1074/Mcp.Ra117.000370  0.4
2017 Shao H, Wang A, Lauffenburger D, Wells A. Tyro3-mediated phosphorylation of ACTN4 at tyrosines is FAK-dependent and decreases susceptibility to cleavage by m-Calpain. The International Journal of Biochemistry & Cell Biology. PMID 29274473 DOI: 10.1016/J.Biocel.2017.12.014  0.4
2017 Soltis AR, Kennedy NJ, Xin X, Zhou F, Ficarro SB, Yap YS, Matthews BJ, Lauffenburger DA, White FM, Marto JA, Davis RJ, Fraenkel E. Hepatic Dysfunction Caused by Consumption of a High-Fat Diet. Cell Reports. 21: 3317-3328. PMID 29241556 DOI: 10.1016/J.Celrep.2017.11.059  0.4
2017 Sadanand S, Das J, Chung AW, Schoen MK, Lane S, Suscovich TJ, Streeck H, Smith D, Little S, Lauffenburger DA, Richman D, Alter G. Temporal variation in HIV-specific IgG subclass Abs during acute infection differentiates spontaneous controllers from chronic progressors. Aids (London, England). PMID 29239894 DOI: 10.1097/Qad.0000000000001716  0.32
2017 Yoneyama T, Gorry M, Miller MA, Gaither-Davis A, Lin Y, Moss ML, Griffith LG, Lauffenburger DA, Stabile LP, Herman JG, Vujanovic NL. Modification of proteolytic activity matrix analysis (PrAMA) to measure ADAM10 and ADAM17 sheddase activities in cell and tissue lysates. Journal of Cancer. 8: 3916-3932. PMID 29187866 DOI: 10.7150/jca.20779  0.92
2017 Wilson JL, Kefalogianni E, Stopfer L, Harrison C, Sabbisetti VS, Fraenkel E, Lauffenburger DA, Herrlich A. Functional Genomics Approach Identifies Novel Signaling Regulators of TGFα Ectodomain Shedding. Molecular Cancer Research : McR. PMID 29018056 DOI: 10.1158/1541-7786.Mcr-17-0140  0.4
2017 Conrad C, Dorzweiler K, Miller MA, Lauffenburger DA, Strik H, Bartsch JW. Profiling of metalloprotease activities in cerebrospinal fluids of patients with neoplastic meningitis. Fluids and Barriers of the Cns. 14: 22. PMID 28806983 DOI: 10.1186/s12987-017-0070-5  0.44
2017 Shao H, Lauffenburger D, Wells A. Tyro3 carboxyl terminal region confers stability and contains the autophosphorylation sites. Biochemical and Biophysical Research Communications. PMID 28668391 DOI: 10.1016/J.Bbrc.2017.06.168  0.4
2017 Chen WLK, Edington C, Suter E, Yu J, Velazquez JJ, Velazquez JG, Shockley M, Large EM, Venkataramanan R, Hughes DJ, Stokes CL, Trumper DL, Carrier RL, Cirit M, Griffith LG, ... Lauffenburger DA, et al. Integrated Gut/Liver Microphysiological Systems Elucidates Inflammatory Inter-Tissue Crosstalk. Biotechnology and Bioengineering. PMID 28667746 DOI: 10.1002/Bit.26370  0.92
2017 Janes KA, Chandran PL, Ford RM, Lazzara MJ, Papin JA, Peirce SM, Saucerman JJ, Lauffenburger DA. An engineering design approach to systems biology. Integrative Biology : Quantitative Biosciences From Nano to Macro. PMID 28590470 DOI: 10.1039/C7Ib00014F  1
2017 Sarkar U, Ravindra KC, Large E, Young CL, Rivera-Burgos D, Yu J, Cirit M, Hughes DJ, Wishnok JS, Lauffenburger DA, Griffith LG, Tannenbaum SR. Integrated assessment of diclofenac biotransformation, pharmacokinetics, and omics-based toxicity in a 3D human liver-immunocompetent co-culture system. Drug Metabolism and Disposition: the Biological Fate of Chemicals. PMID 28450578 DOI: 10.1124/Dmd.116.074005  0.92
2017 Jørgensen H, Hill AS, Beste MT, Kumar MP, Chiswick E, Fedorcsak P, Isaacson KB, Lauffenburger DA, Griffith LG, Qvigstad E. Peritoneal fluid cytokines related to endometriosis in patients evaluated for infertility. Fertility and Sterility. PMID 28433374 DOI: 10.1016/J.Fertnstert.2017.03.013  0.92
2017 Valdez J, Cook CD, Ahrens CC, Wang AJ, Brown A, Kumar M, Stockdale L, Rothenberg D, Renggli K, Gordon E, Lauffenburger D, White F, Griffith L. On-demand dissolution of modular, synthetic extracellular matrix reveals local epithelial-stromal communication networks. Biomaterials. 130: 90-103. PMID 28371736 DOI: 10.1016/J.Biomaterials.2017.03.030  0.32
2017 Cook CD, Hill AS, Guo M, Stockdale L, Papps JP, Isaacson KB, Lauffenburger DA, Griffith LG. Local remodeling of synthetic extracellular matrix microenvironments by co-cultured endometrial epithelial and stromal cells enables long-term dynamic physiological function. Integrative Biology : Quantitative Biosciences From Nano to Macro. PMID 28317948 DOI: 10.1039/c6ib00245e  0.92
2017 Conrad C, Miller MA, Bartsch JW, Schlomann U, Lauffenburger DA. Simultaneous Detection of Metalloprotease Activities in Complex Biological Samples Using the PrAMA (Proteolytic Activity Matrix Assay) Method. Methods in Molecular Biology (Clifton, N.J.). 1574: 243-253. PMID 28315256 DOI: 10.1007/978-1-4939-6850-3_18  0.44
2017 Dugast AS, Arnold K, Lofano G, Moore S, Hoffner M, Simek M, Poignard P, Seaman M, Suscovich T, Pereyra F, Walker BD, Lauffenburger D, Kwon D, Keele BF, Alter G. Virus-driven inflammation is associated with the development of bNAbs in spontaneous controllers of HIV. Clinical Infectious Diseases : An Official Publication of the Infectious Diseases Society of America. PMID 28158448 DOI: 10.1093/Cid/Cix057  0.32
2017 Moynihan KD, Opel C, Szeto G, Tzeng A, Eric Z, Engreitz J, Robert W, Rakhra K, Zhang M, Rothschilds A, Kumari S, Kelly RL, Kwan B, Abraham W, Hu K, ... ... Lauffenburger DA, et al. Abstract A52: Eradication of large established tumors with combination immunotherapy engaging innate and adaptive immunity Cancer Immunology Research. 5. DOI: 10.1158/2326-6074.Tumimm16-A52  0.6
2017 Clark AM, Wheeler SE, Young CL, Neiman JS, Pillai V, Stockdale L, Stolz D, Lauffenburger DA, Venkataramanan R, Griffith LG, Wells A. Abstract A01: Mechanical properties of matrices strongly influence spontaneous tumor dormancy and responses to chemotherapy in a 3D model of metastasis Cancer Research. 77. DOI: 10.1158/1538-7445.Epso16-A01  0.92
2016 Tan L, Gurbani D, Weisberg EL, Jones DS, Rao S, Singer WD, Bernard FM, Mowafy S, Jenney A, Du G, Nonami A, Griffin JD, Lauffenburger DA, Westover KD, Sorger PK, et al. Studies of TAK1-centered polypharmacology with novel covalent TAK1 inhibitors. Bioorganic & Medicinal Chemistry. PMID 28038940 DOI: 10.1016/J.Bmc.2016.11.034  0.4
2016 Miller MA, Sullivan RJ, Lauffenburger DA. Molecular Pathways: Receptor Ectodomain Shedding in Treatment, Resistance, and Monitoring of Cancer. Clinical Cancer Research : An Official Journal of the American Association For Cancer Research. PMID 27895032 DOI: 10.1158/1078-0432.CCR-16-0869  0.44
2016 Jones DS, Jenney AP, Swantek JL, Burke JM, Lauffenburger DA, Sorger PK. Profiling drugs for rheumatoid arthritis that inhibit synovial fibroblast activation. Nature Chemical Biology. PMID 27820799 DOI: 10.1038/nchembio.2211  0.4
2016 Sun D, Dalin S, Hemann MT, Lauffenburger DA, Zhao B. Differential selective pressure alters rate of drug resistance acquisition in heterogeneous tumor populations. Scientific Reports. 6: 36198. PMID 27819268 DOI: 10.1038/Srep36198  0.76
2016 Oudin MJ, Barbier L, Schäfer C, Kosciuk T, Miller MA, Han S, Jonas O, Lauffenburger DA, Gertler FB. Mena confers resistance to Paclitaxel in triple-negative breast cancer. Molecular Cancer Therapeutics. PMID 27811011 DOI: 10.1158/1535-7163.Mct-16-0413  0.44
2016 Liebenberg LJ, Masson L, Arnold KB, Mckinnon LR, Werner L, Proctor E, Archary D, Mansoor LE, Lauffenburger DA, Abdool Karim Q, Abdool Karim SS, Passmore JS. Genital - Systemic chemokine gradients and the risk of HIV acquisition in women. Journal of Acquired Immune Deficiency Syndromes (1999). PMID 27787345 DOI: 10.1097/QAI.0000000000001218  0.32
2016 Moynihan KD, Opel CF, Szeto GL, Tzeng A, Zhu EF, Engreitz JM, Williams RT, Rakhra K, Zhang MH, Rothschilds AM, Kumari S, Kelly RL, Kwan BH, Abraham W, Hu K, ... ... Lauffenburger DA, et al. Eradication of large established tumors in mice by combination immunotherapy that engages innate and adaptive immune responses. Nature Medicine. PMID 27775706 DOI: 10.1038/Nm.4200  0.6
2016 Lu LL, Chung AW, Rosebrock TR, Ghebremichael M, Yu WH, Grace PS, Schoen MK, Tafesse F, Martin C, Leung V, Mahan AE, Sips M, Kumar MP, Tedesco J, Robinson H, ... ... Lauffenburger DA, et al. A Functional Role for Antibodies in Tuberculosis. Cell. PMID 27667685 DOI: 10.1016/J.Cell.2016.08.072  0.36
2016 Oudin MJ, Miller MA, Klazen JA, Kosciuk T, Lussiez A, Hughes SK, Tadros J, Bear JE, Lauffenburger DA, Gertler FB. MenaINV mediates synergistic crosstalk between signaling pathways driving chemotaxis and haptotaxis. Molecular Biology of the Cell. PMID 27559126 DOI: 10.1091/Mbc.E16-04-0212  0.44
2016 Wilson JL, Dalin S, Gosline S, Hemann M, Fraenkel E, Lauffenburger DA. Pathway-based network modeling finds hidden genes in shRNA screen for regulators of acute lymphoblastic leukemia. Integrative Biology : Quantitative Biosciences From Nano to Macro. PMID 27315426 DOI: 10.1039/C6Ib00040A  0.56
2016 Chitforoushzadeh Z, Ye Z, Sheng Z, LaRue S, Fry RC, Lauffenburger DA, Janes KA. TNF-insulin crosstalk at the transcription factor GATA6 is revealed by a model that links signaling and transcriptomic data tensors. Science Signaling. 9: ra59. PMID 27273097 DOI: 10.1126/Scisignal.Aad3373  0.88
2016 Archary D, Seaton KE, Passmore JS, Werner L, Deal A, Dunphy LJ, Arnold KB, Yates NL, Lauffenburger DA, Bergin P, Liebenberg LJ, Samsunder N, Mureithi MW, Altfeld M, Garrett N, et al. Distinct genital tract HIV-specific antibody profiles associated with tenofovir gel. Mucosal Immunology. 9: 834. PMID 27116933 DOI: 10.1038/mi.2016.21  0.32
2016 Tape CJ, Ling S, Dimitriadi M, McMahon KM, Worboys JD, Leong HS, Norrie IC, Miller CJ, Poulogiannis G, Lauffenburger DA, Jørgensen C. Oncogenic KRAS Regulates Tumor Cell Signaling via Stromal Reciprocation. Cell. PMID 27087446 DOI: 10.1016/j.cell.2016.03.029  0.88
2016 Miller MA, Oudin MJ, Sullivan RJ, Wang SJ, Meyer AS, Im H, Frederick DT, Tadros J, Griffith LG, Lee H, Weissleder R, Flaherty KT, Gertler FB, Lauffenburger DA. Reduced Proteolytic Shedding of Receptor Tyrosine Kinases Is a Post-Translational Mechanism of Kinase Inhibitor Resistance. Cancer Discovery. PMID 26984351 DOI: 10.1158/2159-8290.Cd-15-0933  1
2016 Zhao B, Sedlak JC, Srinivas R, Creixell P, Pritchard JR, Tidor B, Lauffenburger DA, Hemann MT. Exploiting Temporal Collateral Sensitivity in Tumor Clonal Evolution. Cell. PMID 26924578 DOI: 10.1016/J.Cell.2016.01.045  1
2016 Oudin MJ, Jonas O, Kosciuk T, Broye LC, Guido BC, Wyckoff J, Riquelme D, Lamar JM, Asokan SB, Whittaker C, Ma D, Langer R, Cima MJ, Wisinski KB, Hynes RO, ... Lauffenburger DA, et al. Tumor cell-driven extracellular matrix remodeling enables haptotaxis during metastatic progression. Cancer Discovery. PMID 26811325 DOI: 10.1158/2159-8290.Cd-15-1183  0.32
2016 Oudin MJ, Jonas O, Kosciuk T, Broye L, Wyckoff J, Klazen J, Lamar J, Asokan S, Whittaker C, Langer R, Cima M, Wisinski K, Hynes R, Lauffenburger D, Keely P, et al. Abstract PR15: Haptotaxis and direct remodeling of the extracellular matrix by tumor cells is important for metastasis Cancer Research. 76. DOI: 10.1158/1538-7445.Tummet15-Pr15  0.32
2016 Clark AM, Wheeler SE, Young CL, Pillai VC, Stolz DB, Lauffenburger DA, Venkataramanan R, Griffith LG, Wells A. Abstract PR11: Elucidating candidate biomarkers of breast cancer progression and dormancy using a 3D model of metastasis Cancer Research. 76. DOI: 10.1158/1538-7445.Tummet15-Pr11  0.92
2016 Zhao B, Hemann MT, Lauffenburger DA. Modeling tumor clonal evolution for drug combinations design Trends in Cancer. 2: 144-158. DOI: 10.1016/j.trecan.2016.02.001  1
2015 Gierut JJ, Wood LB, Lau KS, Lin YJ, Genetti C, Samatar AA, Lauffenburger DA, Haigis KM. Network-level effects of kinase inhibitors modulate TNF-α-induced apoptosis in the intestinal epithelium. Science Signaling. 8: ra129. PMID 26671150 DOI: 10.1126/Scisignal.Aac7235  0.88
2015 Gordonov S, Hwang MK, Wells A, Gertler FB, Lauffenburger DA, Bathe M. Time series modeling of live-cell shape dynamics for image-based phenotypic profiling. Integrative Biology : Quantitative Biosciences From Nano to Macro. PMID 26658688 DOI: 10.1039/C5Ib00283D  1
2015 Wood LB, Winslow AR, Proctor EA, McGuone D, Mordes DA, Frosch MP, Hyman BT, Lauffenburger DA, Haigis KM. Identification of neurotoxic cytokines by profiling Alzheimer's disease tissues and neuron culture viability screening. Scientific Reports. 5: 16622. PMID 26564777 DOI: 10.1038/Srep16622  0.88
2015 Chung AW, Kumar MP, Arnold KB, Yu WH, Schoen MK, Dunphy LJ, Suscovich TJ, Frahm N, Linde C, Mahan AE, Hoffner M, Streeck H, Ackerman ME, McElrath MJ, Schuitemaker H, ... ... Lauffenburger DA, et al. Dissecting Polyclonal Vaccine-Induced Humoral Immunity against HIV Using Systems Serology. Cell. 163: 988-98. PMID 26544943 DOI: 10.1016/J.Cell.2015.10.027  1
2015 Yu J, Cilfone NA, Large EM, Sarkar U, Wishnok JS, Tannenbaum SR, Hughes DJ, Lauffenburger DA, Griffith LG, Stokes CL, Cirit M. Quantitative Systems Pharmacology Approaches Applied to Microphysiological Systems (MPS): Data Interpretation and Multi-MPS Integration. Cpt: Pharmacometrics & Systems Pharmacology. 4: 585-94. PMID 26535159 DOI: 10.1002/psp4.12010  0.92
2015 Masson L, Arnold KB, Little F, Mlisana K, Lewis DA, Mkhize N, Gamieldien H, Ngcapu S, Johnson L, Lauffenburger DA, Abdool Karim Q, Abdool Karim SS, Passmore JS. Inflammatory cytokine biomarkers to identify women with asymptomatic sexually transmitted infections and bacterial vaginosis who are at high risk of HIV infection. Sexually Transmitted Infections. PMID 26511781 DOI: 10.1136/Sextrans-2015-052072  0.32
2015 Arnold KB, Szeto GL, Alter G, Irvine DJ, Lauffenburger DA. CD4+ T cell-dependent and CD4+ T cell-independent cytokine-chemokine network changes in the immune responses of HIV-infected individuals. Science Signaling. 8: ra104. PMID 26486173 DOI: 10.1126/Scisignal.Aab0808  0.6
2015 Miller MA, Moss ML, Powell G, Petrovich R, Edwards L, Meyer AS, Griffith LG, Lauffenburger DA. Targeting autocrine HB-EGF signaling with specific ADAM12 inhibition using recombinant ADAM12 prodomain. Scientific Reports. 5: 15150. PMID 26477568 DOI: 10.1038/srep15150  1
2015 Hughes SK, Oudin MJ, Tadros J, Neil J, Del Rosario A, Joughin BA, Ritsma L, Wyckoff J, Vasile E, Eddy R, Philippar U, Lussiez A, Condeelis JS, van Rheenen J, White F, ... Lauffenburger DA, et al. PTP1B-dependent regulation of receptor tyrosine kinase signaling by the actin-binding protein Mena. Molecular Biology of the Cell. PMID 26337385 DOI: 10.1091/Mbc.E15-06-0442  1
2015 Meyer AS, Zweemer AJ, Lauffenburger DA. The AXL Receptor is a Sensor of Ligand Spatial Heterogeneity. Cell Systems. 1: 25-36. PMID 26236777 DOI: 10.1016/j.cels.2015.06.002  1
2015 Arnold KB, Burgener A, Birse K, Romas L, Dunphy LJ, Shahabi K, Abou M, Westmacott GR, McCorrister S, Kwatampora J, Nyanga B, Kimani J, Masson L, Liebenberg LJ, Abdool Karim SS, ... ... Lauffenburger DA, et al. Increased levels of inflammatory cytokines in the female reproductive tract are associated with altered expression of proteases, mucosal barrier proteins, and an influx of HIV-susceptible target cells. Mucosal Immunology. PMID 26104913 DOI: 10.1038/Mi.2015.51  0.32
2015 Birse K, Arnold KB, Novak RM, McCorrister S, Shaw S, Westmacott GR, Ball TB, Lauffenburger DA, Burgener A. Molecular signatures of immune activation and epithelial barrier remodeling are enhanced during the luteal phase of the menstrual cycle: implications for HIV susceptibility. Journal of Virology. PMID 26085144 DOI: 10.1128/Jvi.00756-15  0.88
2015 Travers T, Shao H, Joughin BA, Lauffenburger DA, Wells A, Camacho CJ. Tandem phosphorylation within an intrinsically disordered region regulates ACTN4 function. Science Signaling. 8: ra51. PMID 26012634 DOI: 10.1126/Scisignal.Aaa1977  1
2015 Melas IN, Sakellaropoulos T, Iorio F, Alexopoulos LG, Loh WY, Lauffenburger DA, Saez-Rodriguez J, Bai JP. Identification of drug-specific pathways based on gene expression data: application to drug induced lung injury. Integrative Biology : Quantitative Biosciences From Nano to Macro. PMID 25932872 DOI: 10.1039/C4Ib00294F  0.88
2015 Masson L, Passmore JA, Liebenberg LJ, Werner L, Baxter C, Arnold KB, Williamson C, Little F, Mansoor LE, Naranbhai V, Lauffenburger DA, Ronacher K, Walzl G, Garrett NJ, Williams BL, et al. Genital Inflammation and the Risk of HIV Acquisition in Women. Clinical Infectious Diseases : An Official Publication of the Infectious Diseases Society of America. 61: 260-9. PMID 25900168 DOI: 10.1093/Cid/Civ298  1
2015 Li JZ, Arnold KB, Lo J, Dugast AS, Plants J, Ribaudo HJ, Cesa K, Heisey A, Kuritzkes DR, Lauffenburger DA, Alter G, Landay A, Grinspoon S, Pereyra F. Differential levels of soluble inflammatory markers by human immunodeficiency virus controller status and demographics. Open Forum Infectious Diseases. 2: ofu117. PMID 25884005 DOI: 10.1093/Ofid/Ofu117  0.32
2015 Wu L, Claas AM, Sarkar A, Lauffenburger DA, Han J. High-throughput protease activity cytometry reveals dose-dependent heterogeneity in PMA-mediated ADAM17 activation. Integrative Biology : Quantitative Biosciences From Nano to Macro. 7: 513-24. PMID 25832727 DOI: 10.1039/C5Ib00019J  0.88
2015 Schlomann U, Koller G, Conrad C, Ferdous T, Golfi P, Garcia AM, Höfling S, Parsons M, Costa P, Soper R, Bossard M, Hagemann T, Roshani R, Sewald N, Ketchem RR, ... ... Lauffenburger DA, et al. ADAM8 as a drug target in pancreatic cancer. Nature Communications. 6: 6175. PMID 25629724 DOI: 10.1038/Ncomms7175  0.88
2015 Ng EX, Miller MA, Jing T, Lauffenburger DA, Chen CH. Low-volume multiplexed proteolytic activity assay and inhibitor analysis through a pico-injector array. Lab On a Chip. 15: 1153-9. PMID 25553996 DOI: 10.1039/c4lc01162g  1
2015 Lauffenburger DA. Innovation and insight in integrative biology. Integrative Biology : Quantitative Biosciences From Nano to Macro. 7: 9. PMID 25500816 DOI: 10.1039/c4ib90047b  1
2015 Zhao B, Hemann MT, Lauffenburger DA. Abstract A31: Combination therapies guided by evolution of tumor heterogeneity. Clinical Cancer Research. 21. DOI: 10.1158/1557-3265.Hemmal14-A31  0.76
2015 Clark AM, Wheeler SE, Taylor DP, Young CL, Pillai VC, Stolz DB, Venkataramanan R, Lauffenburger DA, Griffith LG, Wells A. Abstract P1-07-01: Modeling breast cancer dormancy and re-emergence Cancer Research. 75. DOI: 10.1158/1538-7445.Sabcs14-P1-07-01  0.92
2015 Wilson JL, Fraenkel E, Lauffenburger DA, Herrlich A. Abstract B1-33: Network analyses identify hidden regulators of TGFa shedding Cancer Research. 75. DOI: 10.1158/1538-7445.Compsysbio-B1-33  0.4
2015 Oudin MJ, Miller MA, Kosciuk T, Klazen J, Lussiez A, Lauffenburger D, Bear JE, Gertler FB. Abstract 5057: Mena at the nexus of chemotaxis and haptotaxis during tumor progression Cancer Research. 76: 5057-5057. DOI: 10.1158/1538-7445.Am2016-5057  0.44
2014 Muraro D, Lauffenburger DA, Simmons A. Prioritisation and network analysis of Crohn's disease susceptibility genes. Plos One. 9: e108624. PMID 25268122 DOI: 10.1371/Journal.Pone.0108624  1
2014 Zhao B, Hemann MT, Lauffenburger DA. Reply to Azuaje: Predicting effective combined therapies for heterogeneous tumors. Proceedings of the National Academy of Sciences of the United States of America. 111: E4288. PMID 25253893 DOI: 10.1073/Pnas.1415737111  1
2014 Tape CJ, Worboys JD, Sinclair J, Gourlay R, Vogt J, McMahon KM, Trost M, Lauffenburger DA, Lamont DJ, Jørgensen C. Reproducible automated phosphopeptide enrichment using magnetic TiO2 and Ti-IMAC. Analytical Chemistry. 86: 10296-302. PMID 25233145 DOI: 10.1021/ac5025842  1
2014 Cheow LF, Sarkar A, Kolitz S, Lauffenburger D, Han J. Detecting kinase activities from single cell lysate using concentration-enhanced mobility shift assay. Analytical Chemistry. 86: 7455-62. PMID 25025773 DOI: 10.1021/Ac502185V  0.88
2014 Palmer CD, Tomassilli J, Sirignano M, Romero-Tejeda M, Arnold KB, Che D, Lauffenburger DA, Jost S, Allen T, Mayer KH, Altfeld M. Enhanced immune activation linked to endotoxemia in HIV-1 seronegative MSM. Aids (London, England). 28: 2162-6. PMID 25003719 DOI: 10.1097/Qad.0000000000000386  0.88
2014 Zhao B, Hemann MT, Lauffenburger DA. Intratumor heterogeneity alters most effective drugs in designed combinations. Proceedings of the National Academy of Sciences of the United States of America. 111: 10773-8. PMID 25002493 DOI: 10.1073/Pnas.1323934111  1
2014 Clark AM, Wheeler SE, Taylor DP, Pillai VC, Young CL, Prantil-Baun R, Nguyen T, Stolz DB, Borenstein JT, Lauffenburger DA, Venkataramanan R, Griffith LG, Wells A. A microphysiological system model of therapy for liver micrometastases. Experimental Biology and Medicine (Maywood, N.J.). 239: 1170-9. PMID 24821820 DOI: 10.1177/1535370214532596  1
2014 Tape CJ, Norrie IC, Worboys JD, Lim L, Lauffenburger DA, Jørgensen C. Cell-specific labeling enzymes for analysis of cell-cell communication in continuous co-culture. Molecular & Cellular Proteomics : McP. 13: 1866-76. PMID 24820872 DOI: 10.1074/mcp.O113.037119  0.88
2014 Ebrahimkhani MR, Young CL, Lauffenburger DA, Griffith LG, Borenstein JT. Approaches to in vitro tissue regeneration with application for human disease modeling and drug development. Drug Discovery Today. 19: 754-62. PMID 24793141 DOI: 10.1016/J.Drudis.2014.04.017  1
2014 Sarkar A, Kolitz S, Lauffenburger DA, Han J. Microfluidic probe for single-cell analysis in adherent tissue culture. Nature Communications. 5: 3421. PMID 24594667 DOI: 10.1038/Ncomms4421  0.88
2014 Beste MT, Pfäffle-Doyle N, Prentice EA, Morris SN, Lauffenburger DA, Isaacson KB, Griffith LG. Molecular network analysis of endometriosis reveals a role for c-Jun-regulated macrophage activation. Science Translational Medicine. 6: 222ra16. PMID 24500404 DOI: 10.1126/Scitranslmed.3007988  1
2014 Zhao B, Pritchard JR, Lauffenburger DA, Hemann MT. Addressing genetic tumor heterogeneity through computationally predictive combination therapy. Cancer Discovery. 4: 166-74. PMID 24318931 DOI: 10.1158/2159-8290.Cd-13-0465  1
2014 Arneja A, Johnson H, Gabrovsek L, Lauffenburger DA, White FM. Qualitatively different T cell phenotypic responses to IL-2 versus IL-15 are unified by identical dependences on receptor signal strength and duration. Journal of Immunology (Baltimore, Md. : 1950). 192: 123-35. PMID 24298013 DOI: 10.4049/Jimmunol.1302291  1
2014 Oudin MJ, Broye LC, Lussiez A, Asokan SB, Miller MA, Lauffenburger DA, Bear JE, Gertler FB. Abstract 1988: MenaINV interaction with α5β1 promotes tumor cell invasion in response to gradients of growth factors and fibronectin Cancer Research. 74: 1988-1988. DOI: 10.1158/1538-7445.Am2014-1988  0.44
2014 Young CL, Griffith LG, Lauffenburger DA. Evaluation of biomolecular metrics in microphysiological systems: Technical challenges associated with multiplex arrays Proceedings of the Ieee Annual Northeast Bioengineering Conference, Nebec. 2014. DOI: 10.1109/NEBEC.2014.6972992  0.88
2014 Koppes AN, Carrier RL, Baranov PY, Young MJ, Oudin MJ, Gertler FB, Miller MA, Lauffenburger DA. High-throughput screening for directed chemotaxis of retinal progenitor cells in 3D hydrogels Proceedings of the Ieee Annual Northeast Bioengineering Conference, Nebec. 2014. DOI: 10.1109/NEBEC.2014.6972844  0.44
2014 Lauffenburger DA. Evolution of a biological journal Integrative Biology (United Kingdom). 6: 8. DOI: 10.1039/c3ib90043f  1
2013 Melas IN, Lauffenburger DA, Alexopoulos LG. Identification of signaling pathways related to drug efficacy in hepatocellular carcinoma via integration of phosphoproteomic, genomic and clinical data. Proceedings / Annual Ieee International Symposium On Bioinformatics and Bioengineering (Bibe). Ieee International Symposium On Bioinformatics and Bioengineering. 2013. PMID 25729777 DOI: 10.1109/BIBE.2013.6701683  1
2013 Wheeler SE, Borenstein JT, Clark AM, Ebrahimkhani MR, Fox IJ, Griffith L, Inman W, Lauffenburger D, Nguyen T, Pillai VC, Prantil-Baun R, Stolz DB, Taylor D, Ulrich T, Venkataramanan R, et al. All-human microphysical model of metastasis therapy. Stem Cell Research & Therapy. 4: S11. PMID 24565274 DOI: 10.1186/Scrt372  1
2013 Jamison J, Lauffenburger D, Wang JC, Wells A. PKCδ localization at the membrane increases matrix traction force dependent on PLCγ1/EGFR signaling. Plos One. 8: e77434. PMID 24155954 DOI: 10.1371/Journal.Pone.0077434  0.4
2013 Simmons RP, Scully EP, Groden EE, Arnold KB, Chang JJ, Lane K, Lifson J, Rosenberg E, Lauffenburger DA, Altfeld M. HIV-1 infection induces strong production of IP-10 through TLR7/9-dependent pathways. Aids (London, England). 27: 2505-17. PMID 24096630 DOI: 10.1097/01.aids.0000432455.06476.bc  1
2013 Lau KS, Schrier SB, Gierut J, Lyons J, Lauffenburger DA, Haigis KM. Network analysis of differential Ras isoform mutation effects on intestinal epithelial responses to TNF-α. Integrative Biology : Quantitative Biosciences From Nano to Macro. 5: 1355-65. PMID 24084984 DOI: 10.1039/C3Ib40062J  1
2013 Hang TC, Tedford NC, Reddy RJ, Rimchala T, Wells A, White FM, Kamm RD, Lauffenburger DA. Vascular endothelial growth factor (VEGF) and platelet (PF-4) factor 4 inputs modulate human microvascular endothelial signaling in a three-dimensional matrix migration context. Molecular & Cellular Proteomics : McP. 12: 3704-18. PMID 24023389 DOI: 10.1074/Mcp.M113.030528  1
2013 Meyer AS, Miller MA, Gertler FB, Lauffenburger DA. The receptor AXL diversifies EGFR signaling and limits the response to EGFR-targeted inhibitors in triple-negative breast cancer cells. Science Signaling. 6: ra66. PMID 23921085 DOI: 10.1126/Scisignal.2004155  1
2013 Wagner JP, Wolf-Yadlin A, Sevecka M, Grenier JK, Root DE, Lauffenburger DA, MacBeath G. Receptor tyrosine kinases fall into distinct classes based on their inferred signaling networks. Science Signaling. 6: ra58. PMID 23861540 DOI: 10.4172/2153-0602.C1.003  1
2013 Wilson JL, Hemann MT, Fraenkel E, Lauffenburger DA. Integrated network analyses for functional genomic studies in cancer. Seminars in Cancer Biology. 23: 213-8. PMID 23811269 DOI: 10.1016/J.Semcancer.2013.06.004  1
2013 Janes KA, Lauffenburger DA. Models of signalling networks - what cell biologists can gain from them and give to them. Journal of Cell Science. 126: 1913-21. PMID 23720376 DOI: 10.1242/jcs.112045  1
2013 Dang M, Armbruster N, Miller MA, Cermeno E, Hartmann M, Bell GW, Root DE, Lauffenburger DA, Lodish HF, Herrlich A. Regulated ADAM17-dependent EGF family ligand release by substrate-selecting signaling pathways. Proceedings of the National Academy of Sciences of the United States of America. 110: 9776-81. PMID 23720309 DOI: 10.1073/Pnas.1307478110  1
2013 Miraldi ER, Sharfi H, Friedline RH, Johnson H, Zhang T, Lau KS, Ko HJ, Curran TG, Haigis KM, Yaffe MB, Bonneau R, Lauffenburger DA, Kahn BB, Kim JK, Neel BG, et al. Molecular network analysis of phosphotyrosine and lipid metabolism in hepatic PTP1b deletion mice. Integrative Biology : Quantitative Biosciences From Nano to Macro. 5: 940-63. PMID 23685806 DOI: 10.1039/C3Ib40013A  0.88
2013 Miller MA, Meyer AS, Beste MT, Lasisi Z, Reddy S, Jeng KW, Chen CH, Han J, Isaacson K, Griffith LG, Lauffenburger DA. ADAM-10 and -17 regulate endometriotic cell migration via concerted ligand and receptor shedding feedback on kinase signaling. Proceedings of the National Academy of Sciences of the United States of America. 110: E2074-83. PMID 23674691 DOI: 10.1073/Pnas.1222387110  1
2013 Wells A, Grahovac J, Wheeler S, Ma B, Lauffenburger D. Targeting tumor cell motility as a strategy against invasion and metastasis. Trends in Pharmacological Sciences. 34: 283-9. PMID 23571046 DOI: 10.1016/J.Tips.2013.03.001  1
2013 Huang SS, Clarke DC, Gosline SJ, Labadorf A, Chouinard CR, Gordon W, Lauffenburger DA, Fraenkel E. Linking proteomic and transcriptional data through the interactome and epigenome reveals a map of oncogene-induced signaling. Plos Computational Biology. 9: e1002887. PMID 23408876 DOI: 10.1371/Journal.Pcbi.1002887  1
2013 Rimchala T, Kamm RD, Lauffenburger DA. Endothelial cell phenotypic behaviors cluster into dynamic state transition programs modulated by angiogenic and angiostatic cytokines. Integrative Biology : Quantitative Biosciences From Nano to Macro. 5: 510-22. PMID 23303249 DOI: 10.1039/C2Ib20090B  1
2013 Pritchard JR, Bruno PM, Hemann MT, Lauffenburger DA. Predicting cancer drug mechanisms of action using molecular network signatures. Molecular Biosystems. 9: 1604-19. PMID 23287973 DOI: 10.1039/C2Mb25459J  1
2013 Pritchard JR, Bruno PM, Gilbert LA, Capron KL, Lauffenburger DA, Hemann MT. Defining principles of combination drug mechanisms of action. Proceedings of the National Academy of Sciences of the United States of America. 110: E170-9. PMID 23251029 DOI: 10.1073/Pnas.1210419110  1
2013 Lauffenburger DA. Our new look at biology. Integrative Biology : Quantitative Biosciences From Nano to Macro. 5: 15-6. PMID 23223812 DOI: 10.1039/c2ib90056d  1
2013 Chen CH, Miller MA, Sarkar A, Beste MT, Isaacson KB, Lauffenburger DA, Griffith LG, Han J. Multiplexed protease activity assay for low-volume clinical samples using droplet-based microfluidics and its application to endometriosis. Journal of the American Chemical Society. 135: 1645-8. PMID 23157326 DOI: 10.1021/Ja307866Z  1
2013 Paradise RK, Whitfield MJ, Lauffenburger DA, Van Vliet KJ. Directional cell migration in an extracellular pH gradient: a model study with an engineered cell line and primary microvascular endothelial cells. Experimental Cell Research. 319: 487-97. PMID 23153553 DOI: 10.1016/j.yexcr.2012.11.006  1
2013 Clarke DC, Morris MK, Lauffenburger DA. Normalization and statistical analysis of multiplexed bead-based immunoassay data using mixed-effects modeling. Molecular & Cellular Proteomics : McP. 12: 245-62. PMID 23071098 DOI: 10.1074/mcp.M112.018655  1
2013 Benedict KF, Lauffenburger DA. Insights into proteomic immune cell signaling and communication via data-driven modeling. Current Topics in Microbiology and Immunology. 363: 201-33. PMID 22878785 DOI: 10.1007/82_2012_249  1
2013 Lauffenburger DA, Zhao B, Pritchard JR, Hemann MT. Abstract IA10: Targeting intratumoral genetic heterogeneity through rationally designed combination therapy Molecular Cancer Therapeutics. 12. DOI: 10.1158/1535-7163.Pms-Ia10  0.76
2013 Lauffenburger DA, VanHook AM. Science signaling podcast: 6 August 2013 Science Signaling. 6. DOI: 10.1126/Scisignal.2004499  1
2012 Mitsos A, Melas IN, Morris MK, Saez-Rodriguez J, Lauffenburger DA, Alexopoulos LG. Non Linear Programming (NLP) formulation for quantitative modeling of protein signal transduction pathways. Plos One. 7: e50085. PMID 23226239 DOI: 10.1371/Journal.Pone.0050085  1
2012 Yamanaka YJ, Szeto GL, Gierahn TM, Forcier TL, Benedict KF, Brefo MS, Lauffenburger DA, Irvine DJ, Love JC. Cellular barcodes for efficiently profiling single-cell secretory responses by microengraving. Analytical Chemistry. 84: 10531-6. PMID 23205933 DOI: 10.1021/Ac302264Q  1
2012 Pritchard JR, Lauffenburger DA, Hemann MT. Understanding resistance to combination chemotherapy. Drug Resistance Updates : Reviews and Commentaries in Antimicrobial and Anticancer Chemotherapy. 15: 249-57. PMID 23164555 DOI: 10.1016/J.Drup.2012.10.003  1
2012 Terfve C, Cokelaer T, Henriques D, MacNamara A, Goncalves E, Morris MK, van Iersel M, Lauffenburger DA, Saez-Rodriguez J. CellNOptR: a flexible toolkit to train protein signaling networks to data using multiple logic formalisms. Bmc Systems Biology. 6: 133. PMID 23079107 DOI: 10.1186/1752-0509-6-133  1
2012 Lau KS, Cortez-Retamozo V, Philips SR, Pittet MJ, Lauffenburger DA, Haigis KM. Multi-scale in vivo systems analysis reveals the influence of immune cells on TNF-α-induced apoptosis in the intestinal epithelium. Plos Biology. 10: e1001393. PMID 23055830 DOI: 10.1371/Journal.Pbio.1001393  1
2012 Kolitz SE, Lauffenburger DA. Measurement and modeling of signaling at the single-cell level. Biochemistry. 51: 7433-43. PMID 22954137 DOI: 10.1021/bi300846p  1
2012 Gupton SL, Riquelme D, Hughes-Alford SK, Tadros J, Rudina SS, Hynes RO, Lauffenburger D, Gertler FB. Mena binds α5 integrin directly and modulates α5β1 function. The Journal of Cell Biology. 198: 657-76. PMID 22908313 DOI: 10.1083/Jcb.201202079  1
2012 Noonan EM, Shah D, Yaffe MB, Lauffenburger DA, Samson LD. O6-Methylguanine DNA lesions induce an intra-S-phase arrest from which cells exit into apoptosis governed by early and late multi-pathway signaling network activation. Integrative Biology : Quantitative Biosciences From Nano to Macro. 4: 1237-55. PMID 22892544 DOI: 10.1039/C2Ib20091K  1
2012 Joughin BA, Liu C, Lauffenburger DA, Hogue CW, Yaffe MB. Protein kinases display minimal interpositional dependence on substrate sequence: potential implications for the evolution of signalling networks. Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences. 367: 2574-83. PMID 22889908 DOI: 10.1098/Rstb.2012.0010  1
2012 Naegle KM, White FM, Lauffenburger DA, Yaffe MB. Robust co-regulation of tyrosine phosphorylation sites on proteins reveals novel protein interactions. Molecular Biosystems. 8: 2771-82. PMID 22851037 DOI: 10.1039/C2Mb25200G  1
2012 Meyer AS, Hughes-Alford SK, Kay JE, Castillo A, Wells A, Gertler FB, Lauffenburger DA. 2D protrusion but not motility predicts growth factor-induced cancer cell migration in 3D collagen. The Journal of Cell Biology. 197: 721-9. PMID 22665521 DOI: 10.1083/Jcb.201201003  1
2012 Kirouac DC, Saez-Rodriguez J, Swantek J, Burke JM, Lauffenburger DA, Sorger PK. Creating and analyzing pathway and protein interaction compendia for modelling signal transduction networks. Bmc Systems Biology. 6: 29. PMID 22548703 DOI: 10.1186/1752-0509-6-29  1
2012 Stains CI, Tedford NC, Walkup TC, Lukovi? E, Goguen BN, Griffith LG, Lauffenburger DA, Imperiali B. Interrogating signaling nodes involved in cellular transformations using kinase activity probes. Chemistry & Biology. 19: 210-7. PMID 22365604 DOI: 10.1016/J.Chembiol.2011.11.012  1
2012 Tentner AR, Lee MJ, Ostheimer GJ, Samson LD, Lauffenburger DA, Yaffe MB. Combined experimental and computational analysis of DNA damage signaling reveals context-dependent roles for Erk in apoptosis and G1/S arrest after genotoxic stress. Molecular Systems Biology. 8: 568. PMID 22294094 DOI: 10.1038/Msb.2012.1  1
2012 Hughes-Alford SK, Lauffenburger DA. Quantitative analysis of gradient sensing: towards building predictive models of chemotaxis in cancer. Current Opinion in Cell Biology. 24: 284-91. PMID 22284347 DOI: 10.1016/j.ceb.2012.01.001  1
2012 Clarke DC, Lauffenburger DA. Multi-pathway network analysis of mammalian epithelial cell responses in inflammatory environments. Biochemical Society Transactions. 40: 133-8. PMID 22260679 DOI: 10.1042/BST20110633  1
2012 Han Q, Bagheri N, Bradshaw EM, Hafler DA, Lauffenburger DA, Love JC. Polyfunctional responses by human T cells result from sequential release of cytokines. Proceedings of the National Academy of Sciences of the United States of America. 109: 1607-12. PMID 22160692 DOI: 10.1073/Pnas.1117194109  1
2012 Morris MK, Shriver Z, Sasisekharan R, Lauffenburger DA. Querying quantitative logic models (Q2LM) to study intracellular signaling networks and cell-cytokine interactions. Biotechnology Journal. 7: 374-86. PMID 22125256 DOI: 10.1002/Biot.201100222  1
2012 Hang TC, Lauffenburger DA, Griffith LG, Stolz DB. Lipids promote survival, proliferation, and maintenance of differentiation of rat liver sinusoidal endothelial cells in vitro. American Journal of Physiology. Gastrointestinal and Liver Physiology. 302: G375-88. PMID 22075778 DOI: 10.1152/ajpgi.00288.2011  1
2012 Lauffenburger DA, Pritchard JR, Hemann MT. Abstract SY22-02: Mammalian functional genetic signatures identify efficacy landscapes of combination chemotherapy Cancer Research. 72. DOI: 10.1158/1538-7445.Am2012-Sy22-02  0.76
2012 Sarkar A, Kolitz S, Lauffenburger DA, Han J. An integrated microfluidic probe for multiplexed single cell kinase kinase activity measurement Proceedings of the 16th International Conference On Miniaturized Systems For Chemistry and Life Sciences, Microtas 2012. 416-418.  0.88
2012 Chen CH, Miller MA, Sarkar A, Beste MT, Lauffenburger DA, Griffith LG, Han J. High-throughput mutiplexed protease activity measurement using a droplet based microfluidic platform with picoinjector Proceedings of the 16th International Conference On Miniaturized Systems For Chemistry and Life Sciences, Microtas 2012. 1504-1506.  0.88
2011 Lauffenburger DA. ROCK in a stiff place. Science Translational Medicine. 3: 112fs12. PMID 22158859 DOI: 10.1126/scitranslmed.3003389  1
2011 Aldridge BB, Gaudet S, Lauffenburger DA, Sorger PK. Lyapunov exponents and phase diagrams reveal multi-factorial control over TRAIL-induced apoptosis. Molecular Systems Biology. 7: 553. PMID 22108795 DOI: 10.1038/msb.2011.85  1
2011 Moss ML, Powell G, Miller MA, Edwards L, Qi B, Sang QX, De Strooper B, Tesseur I, Lichtenthaler SF, Taverna M, Zhong JL, Dingwall C, Ferdous T, Schlomann U, Zhou P, ... ... Lauffenburger DA, et al. ADAM9 inhibition increases membrane activity of ADAM10 and controls α-secretase processing of amyloid precursor protein. The Journal of Biological Chemistry. 286: 40443-51. PMID 21956108 DOI: 10.1074/Jbc.M111.280495  1
2011 Kleiman LB, Maiwald T, Conzelmann H, Lauffenburger DA, Sorger PK. Rapid phospho-turnover by receptor tyrosine kinases impacts downstream signaling and drug binding. Molecular Cell. 43: 723-37. PMID 21884975 DOI: 10.1016/j.molcel.2011.07.014  1
2011 Kim HD, Meyer AS, Wagner JP, Alford SK, Wells A, Gertler FB, Lauffenburger DA. Signaling network state predicts twist-mediated effects on breast cell migration across diverse growth factor contexts. Molecular & Cellular Proteomics : McP. 10: M111.008433. PMID 21832255 DOI: 10.1074/Mcp.M111.008433  1
2011 Naegle KM, Welsch RE, Yaffe MB, White FM, Lauffenburger DA. MCAM: multiple clustering analysis methodology for deriving hypotheses and insights from high-throughput proteomic datasets. Plos Computational Biology. 7: e1002119. PMID 21799663 DOI: 10.1371/Journal.Pcbi.1002119  1
2011 Pritchard JR, Gilbert LA, Meacham CE, Ricks JL, Jiang H, Lauffenburger DA, Hemann MT. Bcl-2 family genetic profiling reveals microenvironment-specific determinants of chemotherapeutic response. Cancer Research. 71: 5850-8. PMID 21784872 DOI: 10.1158/0008-5472.Can-11-1014  1
2011 Wu S, Wells A, Griffith LG, Lauffenburger DA. Controlling multipotent stromal cell migration by integrating "course-graining" materials and "fine-tuning" small molecules via decision tree signal-response modeling. Biomaterials. 32: 7524-31. PMID 21782235 DOI: 10.1016/J.Biomaterials.2011.06.050  1
2011 Saez-Rodriguez J, Alexopoulos LG, Zhang M, Morris MK, Lauffenburger DA, Sorger PK. Comparing signaling networks between normal and transformed hepatocytes using discrete logical models. Cancer Research. 71: 5400-11. PMID 21742771 DOI: 10.1158/0008-5472.Can-10-4453  1
2011 Chen CH, Sarkar A, Song YA, Miller MA, Kim SJ, Griffith LG, Lauffenburger DA, Han J. Enhancing protease activity assay in droplet-based microfluidics using a biomolecule concentrator. Journal of the American Chemical Society. 133: 10368-71. PMID 21671557 DOI: 10.1021/Ja2036628  1
2011 Roussos ET, Balsamo M, Alford SK, Wyckoff JB, Gligorijevic B, Wang Y, Pozzuto M, Stobezki R, Goswami S, Segall JE, Lauffenburger DA, Bresnick AR, Gertler FB, Condeelis JS. Mena invasive (MenaINV) promotes multicellular streaming motility and transendothelial migration in a mouse model of breast cancer. Journal of Cell Science. 124: 2120-31. PMID 21670198 DOI: 10.1242/Jcs.086231  1
2011 Peyton SR, Kalcioglu ZI, Cohen JC, Runkle AP, Van Vliet KJ, Lauffenburger DA, Griffith LG. Marrow-derived stem cell motility in 3D synthetic scaffold is governed by geometry along with adhesivity and stiffness. Biotechnology and Bioengineering. 108: 1181-93. PMID 21449030 DOI: 10.1002/Bit.23027  1
2011 Lau KS, Juchheim AM, Cavaliere KR, Philips SR, Lauffenburger DA, Haigis KM. In vivo systems analysis identifies spatial and temporal aspects of the modulation of TNF-α-induced apoptosis and proliferation by MAPKs. Science Signaling. 4: ra16. PMID 21427409 DOI: 10.1126/Scisignal.2001338  1
2011 Morris MK, Saez-Rodriguez J, Clarke DC, Sorger PK, Lauffenburger DA. Training signaling pathway maps to biochemical data with constrained fuzzy logic: quantitative analysis of liver cell responses to inflammatory stimuli. Plos Computational Biology. 7: e1001099. PMID 21408212 DOI: 10.1371/Journal.Pcbi.1001099  1
2011 Bagheri N, Shiina M, Lauffenburger DA, Korn WM. A dynamical systems model for combinatorial cancer therapy enhances oncolytic adenovirus efficacy by MEK-inhibition. Plos Computational Biology. 7: e1001085. PMID 21379332 DOI: 10.1371/Journal.Pcbi.1001085  1
2011 Palmer MJ, Mahajan VS, Chen J, Irvine DJ, Lauffenburger DA. Signaling thresholds govern heterogeneity in IL-7-receptor-mediated responses of naïve CD8(+) T cells. Immunology and Cell Biology. 89: 581-94. PMID 21339767 DOI: 10.1038/Icb.2011.5  1
2011 Paradise RK, Lauffenburger DA, Van Vliet KJ. Acidic extracellular pH promotes activation of integrin α(v)β(3). Plos One. 6: e15746. PMID 21283814 DOI: 10.1371/journal.pone.0015746  1
2011 Wells A, Chao YL, Grahovac J, Wu Q, Lauffenburger DA. Epithelial and mesenchymal phenotypic switchings modulate cell motility in metastasis. Frontiers in Bioscience (Landmark Edition). 16: 815-37. PMID 21196205 DOI: 10.2741/3722  1
2011 Jiang H, Pritchard JR, Williams RT, Lauffenburger DA, Hemann MT. A mammalian functional-genetic approach to characterizing cancer therapeutics. Nature Chemical Biology. 7: 92-100. PMID 21186347 DOI: 10.1038/Nchembio.503  1
2011 Miller MA, Barkal L, Jeng K, Herrlich A, Moss M, Griffith LG, Lauffenburger DA. Proteolytic Activity Matrix Analysis (PrAMA) for simultaneous determination of multiple protease activities. Integrative Biology : Quantitative Biosciences From Nano to Macro. 3: 422-38. PMID 21180771 DOI: 10.1039/c0ib00083c  1
2011 Wu R, Goldsipe A, Schauer DB, Lauffenburger DA. Cellular defense processes regulated by pathogen-elicited receptor signaling Proceedings of Spie - the International Society For Optical Engineering. 8058. DOI: 10.1117/12.889123  1
2011 Sarkar A, Kolitz S, Cheow LF, Lauffenburger DA, Han J. An integrated microfluidic probe for concentration-enhanced selective single cell kinase activity measurement 15th International Conference On Miniaturized Systems For Chemistry and Life Sciences 2011, Microtas 2011. 2: 1394-1396.  0.88
2011 Chen CH, Sarkar A, Song YA, Miller MA, Kim SJ, Griffith LG, Lauffenburger DA, Han J. Enhancing/multiplexing protease assay with droplet based microfluidics using biomolecule concentrator 15th International Conference On Miniaturized Systems For Chemistry and Life Sciences 2011, Microtas 2011. 3: 2080-2082.  0.88
2011 Cheow LF, Sarkar A, Kolitz S, Lauffenburger D, Han J. Concentration enhanced mobility shift assay with applications to aptamer-based biomarker detection and kinase profiling 15th International Conference On Miniaturized Systems For Chemistry and Life Sciences 2011, Microtas 2011. 2: 1023-1025.  0.88
2010 Naegle KM, Gymrek M, Joughin BA, Wagner JP, Welsch RE, Yaffe MB, Lauffenburger DA, White FM. PTMScout, a Web resource for analysis of high throughput post-translational proteomics studies. Molecular & Cellular Proteomics : McP. 9: 2558-70. PMID 20631208 DOI: 10.1074/Mcp.M110.001206  1
2010 Espelin CW, Goldsipe A, Sorger PK, Lauffenburger DA, de Graaf D, Hendriks BS. Elevated GM-CSF and IL-1beta levels compromise the ability of p38 MAPK inhibitors to modulate TNFalpha levels in the human monocytic/macrophage U937 cell line. Molecular Biosystems. 6: 1956-72. PMID 20617251 DOI: 10.1039/c002848g  1
2010 Spangler JB, Neil JR, Abramovitch S, Yarden Y, White FM, Lauffenburger DA, Wittrup KD. Combination antibody treatment down-regulates epidermal growth factor receptor by inhibiting endosomal recycling. Proceedings of the National Academy of Sciences of the United States of America. 107: 13252-7. PMID 20616078 DOI: 10.1073/Pnas.0913476107  1
2010 Prince RN, Schreiter ER, Zou P, Wiley HS, Ting AY, Lee RT, Lauffenburger DA. The heparin-binding domain of HB-EGF mediates localization to sites of cell-cell contact and prevents HB-EGF proteolytic release. Journal of Cell Science. 123: 2308-18. PMID 20530570 DOI: 10.1242/Jcs.058321  1
2010 Kreeger PK, Wang Y, Haigis KM, Lauffenburger DA. Integration of multiple signaling pathway activities resolves K-RAS/N-RAS mutation paradox in colon epithelial cell response to inflammatory cytokine stimulation. Integrative Biology : Quantitative Biosciences From Nano to Macro. 2: 202-8. PMID 20473400 DOI: 10.1039/B925935J  1
2010 Alexopoulos LG, Saez-Rodriguez J, Cosgrove BD, Lauffenburger DA, Sorger PK. Networks inferred from biochemical data reveal profound differences in toll-like receptor and inflammatory signaling between normal and transformed hepatocytes. Molecular & Cellular Proteomics : McP. 9: 1849-65. PMID 20460255 DOI: 10.1074/Mcp.M110.000406  1
2010 Joslin EJ, Shankaran H, Opresko LK, Bollinger N, Lauffenburger DA, Wiley HS. Structure of the EGF receptor transactivation circuit integrates multiple signals with cell context. Molecular Biosystems. 6: 1293-306. PMID 20458382 DOI: 10.1039/C003921G  1
2010 Lazzara MJ, Lane K, Chan R, Jasper PJ, Yaffe MB, Sorger PK, Jacks T, Neel BG, Lauffenburger DA. Impaired SHP2-mediated extracellular signal-regulated kinase activation contributes to gefitinib sensitivity of lung cancer cells with epidermal growth factor receptor-activating mutations. Cancer Research. 70: 3843-50. PMID 20406974 DOI: 10.1158/0008-5472.Can-09-3421  1
2010 Cosgrove BD, Alexopoulos LG, Hang TC, Hendriks BS, Sorger PK, Griffith LG, Lauffenburger DA. Cytokine-associated drug toxicity in human hepatocytes is associated with signaling network dysregulation. Molecular Biosystems. 6: 1195-206. PMID 20361094 DOI: 10.1039/B926287C  1
2010 Morris MK, Saez-Rodriguez J, Sorger PK, Lauffenburger DA. Logic-based models for the analysis of cell signaling networks. Biochemistry. 49: 3216-24. PMID 20225868 DOI: 10.1021/Bi902202Q  1
2010 Ciaccio MF, Wagner JP, Chuu CP, Lauffenburger DA, Jones RB. Systems analysis of EGF receptor signaling dynamics with microwestern arrays. Nature Methods. 7: 148-55. PMID 20101245 DOI: 10.1038/Nmeth.1418  1
2010 Kreeger PK, Lauffenburger DA. Cancer systems biology: a network modeling perspective. Carcinogenesis. 31: 2-8. PMID 19861649 DOI: 10.1093/Carcin/Bgp261  1
2010 Shiina M, Bagheri N, Lauffenburger D, Korn WM. Abstract 3494: Experimentally validated modeling for optimizing therapeutic combinations of oncolytic adenoviruses and MEK inhibitor Cancer Research. 70: 3494-3494. DOI: 10.1158/1538-7445.Am10-3494  0.4
2010 Joughin BA, Cheung E, Karuturi RKM, Saez-Rodriguez J, Lauffenburger DA, Liu ET. Cellular Regulatory Networks Systems Biomedicine. 57-108. DOI: 10.1016/B978-0-12-372550-9.00004-3  0.88
2010 Liu ET, Lauffenburger DA. Systems Biomedicine Systems Biomedicine 0.88
2009 Cosgrove BD, Alexopoulos LG, Saez-Rodriguez J, Griffith LG, Lauffenburger DA. A multipathway phosphoproteomic signaling network model of idiosyncratic drug- and inflammatory cytokine-induced toxicity in human hepatocytes. Conference Proceedings : ... Annual International Conference of the Ieee Engineering in Medicine and Biology Society. Ieee Engineering in Medicine and Biology Society. Annual Conference. 2009: 5452-5. PMID 19964679 DOI: 10.1109/IEMBS.2009.5334019  1
2009 Saez-Rodriguez J, Alexopoulos LG, Epperlein J, Samaga R, Lauffenburger DA, Klamt S, Sorger PK. Discrete logic modelling as a means to link protein signalling networks with functional analysis of mammalian signal transduction. Molecular Systems Biology. 5: 331. PMID 19953085 DOI: 10.1038/Msb.2009.87  1
2009 Kreeger PK, Mandhana R, Alford SK, Haigis KM, Lauffenburger DA. RAS mutations affect tumor necrosis factor-induced apoptosis in colon carcinoma cells via ERK-modulatory negative and positive feedback circuits along with non-ERK pathway effects. Cancer Research. 69: 8191-9. PMID 19789336 DOI: 10.1158/0008-5472.Can-09-1921  1
2009 Wittmann DM, Krumsiek J, Saez-Rodriguez J, Lauffenburger DA, Klamt S, Theis FJ. Transforming Boolean models to continuous models: methodology and application to T-cell receptor signaling. Bmc Systems Biology. 3: 98. PMID 19785753 DOI: 10.1186/1752-0509-3-98  1
2009 Platt MO, Wilder CL, Wells A, Griffith LG, Lauffenburger DA. Multipathway kinase signatures of multipotent stromal cells are predictive for osteogenic differentiation: tissue-specific stem cells. Stem Cells (Dayton, Ohio). 27: 2804-14. PMID 19750537 DOI: 10.1002/Stem.215  1
2009 Lee JH, Cosgrove BD, Lauffenburger DA, Han J. Microfluidic concentration-enhanced cellular kinase activity assay. Journal of the American Chemical Society. 131: 10340-1. PMID 19722608 DOI: 10.1021/Ja902594F  1
2009 Pritchard JR, Cosgrove BD, Hemann MT, Griffith LG, Wands JR, Lauffenburger DA. Three-kinase inhibitor combination recreates multipathway effects of a geldanamycin analogue on hepatocellular carcinoma cell death. Molecular Cancer Therapeutics. 8: 2183-92. PMID 19671754 DOI: 10.1158/1535-7163.Mct-08-1203  1
2009 Platt MO, Roman AJ, Wells A, Lauffenburger DA, Griffith LG. Sustained epidermal growth factor receptor levels and activation by tethered ligand binding enhances osteogenic differentiation of multi-potent marrow stromal cells. Journal of Cellular Physiology. 221: 306-17. PMID 19544388 DOI: 10.1002/Jcp.21854  1
2009 Cosgrove BD, King BM, Hasan MA, Alexopoulos LG, Farazi PA, Hendriks BS, Griffith LG, Sorger PK, Tidor B, Xu JJ, Lauffenburger DA. Synergistic drug-cytokine induction of hepatocellular death as an in vitro approach for the study of inflammation-associated idiosyncratic drug hepatotoxicity. Toxicology and Applied Pharmacology. 237: 317-30. PMID 19362101 DOI: 10.1016/J.Taap.2009.04.002  1
2009 Aldridge BB, Saez-Rodriguez J, Muhlich JL, Sorger PK, Lauffenburger DA. Fuzzy logic analysis of kinase pathway crosstalk in TNF/EGF/insulin-induced signaling. Plos Computational Biology. 5: e1000340. PMID 19343194 DOI: 10.1371/Journal.Pcbi.1000340  1
2009 Sachs K, Itani S, Carlisle J, Nolan GP, Pe'er D, Lauffenburger DA. Learning signaling network structures with sparsely distributed data. Journal of Computational Biology : a Journal of Computational Molecular Cell Biology. 16: 201-12. PMID 19193145 DOI: 10.1089/Cmb.2008.07Tt  1
2009 Chen WW, Schoeberl B, Jasper PJ, Niepel M, Nielsen UB, Lauffenburger DA, Sorger PK. Input-output behavior of ErbB signaling pathways as revealed by a mass action model trained against dynamic data. Molecular Systems Biology. 5: 239. PMID 19156131 DOI: 10.1038/Msb.2008.74  1
2009 Joughin BA, Naegle KM, Huang PH, Yaffe MB, Lauffenburger DA, White FM. An integrated comparative phosphoproteomic and bioinformatic approach reveals a novel class of MPM-2 motifs upregulated in EGFRvIII-expressing glioblastoma cells. Molecular Biosystems. 5: 59-67. PMID 19081932 DOI: 10.1039/B815075C  1
2009 Lazzara MJ, Lauffenburger DA. Quantitative modeling perspectives on the erbb system of cell regulatory processes Experimental Cell Research. 315: 717-725. PMID 19022246 DOI: 10.1016/j.yexcr.2008.10.033  1
2009 Ostheimer GJ, Lauffenburger DA, Yaffe MB. Abstract B73: To sleep or die: Cell fate after chemotherapy Cancer Research. 69. DOI: 10.1158/0008-5472.Fbcr09-B73  0.32
2009 Lee JH, Cosgrove BD, Lauffenburger DA, Han J. In-vitro concentration-enhanced cellular kinase activity assays directly from cell lysates Proceedings of Conference, Microtas 2009 - the 13th International Conference On Miniaturized Systems For Chemistry and Life Sciences. 1341-1343.  0.88
2008 Macdonald A, Horwitz AR, Lauffenburger DA. Kinetic model for lamellipodal actin-integrin 'clutch' dynamics. Cell Adhesion & Migration. 2: 95-105. PMID 19262096  1
2008 Philippar U, Roussos ET, Oser M, Yamaguchi H, Kim HD, Giampieri S, Wang Y, Goswami S, Wyckoff JB, Lauffenburger DA, Sahai E, Condeelis JS, Gertler FB. A Mena invasion isoform potentiates EGF-induced carcinoma cell invasion and metastasis. Developmental Cell. 15: 813-28. PMID 19081071 DOI: 10.1016/J.Devcel.2008.09.003  1
2008 Albeck JG, Burke JM, Spencer SL, Lauffenburger DA, Sorger PK. Modeling a snap-action, variable-delay switch controlling extrinsic cell death. Plos Biology. 6: 2831-52. PMID 19053173 DOI: 10.1371/journal.pbio.0060299  0.4
2008 Kim HD, Guo TW, Wu AP, Wells A, Gertler FB, Lauffenburger DA. Epidermal growth factor-induced enhancement of glioblastoma cell migration in 3D arises from an intrinsic increase in speed but an extrinsic matrix- and proteolysis-dependent increase in persistence. Molecular Biology of the Cell. 19: 4249-59. PMID 18632979 DOI: 10.1091/Mbc.E08-05-0501  1
2008 Harley BA, Kim HD, Zaman MH, Yannas IV, Lauffenburger DA, Gibson LJ. Microarchitecture of three-dimensional scaffolds influences cell migration behavior via junction interactions. Biophysical Journal. 95: 4013-24. PMID 18621811 DOI: 10.1529/Biophysj.107.122598  1
2008 Cosgrove BD, Cheng C, Pritchard JR, Stolz DB, Lauffenburger DA, Griffith LG. An inducible autocrine cascade regulates rat hepatocyte proliferation and apoptosis responses to tumor necrosis factor-alpha. Hepatology (Baltimore, Md.). 48: 276-88. PMID 18536058 DOI: 10.1002/hep.22335  1
2008 Palmer MJ, Mahajan VS, Trajman LC, Irvine DJ, Lauffenburger DA, Chen J. Interleukin-7 receptor signaling network: an integrated systems perspective. Cellular & Molecular Immunology. 5: 79-89. PMID 18445337 DOI: 10.1038/Cmi.2008.10  1
2008 Albeck JG, Burke JM, Aldridge BB, Zhang M, Lauffenburger DA, Sorger PK. Quantitative analysis of pathways controlling extrinsic apoptosis in single cells. Molecular Cell. 30: 11-25. PMID 18406323 DOI: 10.1016/j.molcel.2008.02.012  1
2008 Kumar N, Afeyan R, Kim HD, Lauffenburger DA. Multipathway model enables prediction of kinase inhibitor cross-talk effects on migration of Her2-overexpressing mammary epithelial cells Molecular Pharmacology. 73: 1668-1678. PMID 18349105 DOI: 10.1124/mol.107.043794  1
2008 Saez-Rodriguez J, Goldsipe A, Muhlich J, Alexopoulos LG, Millard B, Lauffenburger DA, Sorger PK. Flexible informatics for linking experimental data to mathematical models via DataRail. Bioinformatics (Oxford, England). 24: 840-7. PMID 18218655 DOI: 10.1093/Bioinformatics/Btn018  1
2008 Alexopoulos LG, Lauffenburger DA, Sorger PK. Modeling pro-death signaling pathways in cancer hepatocytes using multi-combinatorial treatments of inhibitors and stimuli 8th Ieee International Conference On Bioinformatics and Bioengineering, Bibe 2008. DOI: 10.1109/BIBE.2008.4696732  1
2008 Lazzara MJ, Lauffenburger DA. Altered EGFR trafficking and signaling in lung cancers with kinase-inhibitor-sensitizing mutations Aiche Annual Meeting, Conference Proceedings 1
2008 Miller-Jensen K, Lauffenburger DA, Schaffer DV. Systems biology approaches to studying intracellular signaling interactions between virus and host Aiche Annual Meeting, Conference Proceedings 1
2008 R. Peyton S, Lee HI, Kalcioglu ZI, Kuhlman WA, Lauffenburger DA, Van Vliet KJ, Hammond PT, Griffith LG. 3-D biomaterial design to direct mesenchymal stem cell migration 8th World Biomaterials Congress 2008. 2: 562.  1
2007 Zugates GT, Tedford NC, Zumbuehl A, Jhunjhunwala S, Kang CS, Griffith LG, Lauffenburger DA, Langer R, Anderson DG. Gene delivery properties of end-modified poly(beta-amino ester)s. Bioconjugate Chemistry. 18: 1887-96. PMID 17929884 DOI: 10.1021/Bc7002082  1
2007 Joslin EJ, Opresko LK, Wells A, Wiley HS, Lauffenburger DA. EGF-receptor-mediated mammary epithelial cell migration is driven by sustained ERK signaling from autocrine stimulation. Journal of Cell Science. 120: 3688-99. PMID 17895366 DOI: 10.1242/Jcs.010488  1
2007 Miller-Jensen K, Janes KA, Brugge JS, Lauffenburger DA. Common effector processing mediates cell-specific responses to stimuli. Nature. 448: 604-8. PMID 17637676 DOI: 10.1038/Nature06001  1
2007 Wille L, Kemp ML, Sandy P, Lewis CL, Lauffenburger DA. Epi-allelic Erk1 and Erk2 knockdown series for quantitative analysis of T cell Erk regulation and IL-2 production. Molecular Immunology. 44: 3085-91. PMID 17418417 DOI: 10.1016/J.Molimm.2007.02.008  1
2007 Kharait S, Hautaniemi S, Wu S, Iwabu A, Lauffenburger DA, Wells A. Decision tree modeling predicts effects of inhibiting contractility signaling on cell motility. Bmc Systems Biology. 1: 9. PMID 17408516 DOI: 10.1186/1752-0509-1-9  1
2007 Kemp ML, Wille L, Lewis CL, Nicholson LB, Lauffenburger DA. Quantitative network signal combinations downstream of TCR activation can predict IL-2 production response. Journal of Immunology (Baltimore, Md. : 1950). 178: 4984-92. PMID 17404280 DOI: 10.4049/Jimmunol.178.8.4984  1
2007 Wolf-Yadlin A, Hautaniemi S, Lauffenburger DA, White FM. Multiple reaction monitoring for robust quantitative proteomic analysis of cellular signaling networks. Proceedings of the National Academy of Sciences of the United States of America. 104: 5860-5. PMID 17389395 DOI: 10.1073/Pnas.0608638104  1
2007 Kumar N, Afeyan R, Sheppard S, Harms B, Lauffenburger DA. Quantitative analysis of Akt phosphorylation and activity in response to EGF and insulin treatment Biochemical and Biophysical Research Communications. 354: 14-20. PMID 17214972 DOI: 10.1016/j.bbrc.2006.12.188  1
2007 Kumar N, Wolf-Yadlin A, White FM, Lauffenburger DA. Modeling HER2 effects on cell behavior from mass spectrometry phosphotyrosine data. Plos Computational Biology. 3: e4. PMID 17206861 DOI: 10.1371/Journal.Pcbi.0030004  1
2007 Zaman MH, Matsudaira P, Lauffenburger DA. Understanding effects of matrix protease and matrix organization on directional persistence and translational speed in three-dimensional cell migration. Annals of Biomedical Engineering. 35: 91-100. PMID 17080315 DOI: 10.1007/S10439-006-9205-6  1
2007 Grodzinsky AJ, Kamm RD, Lauffenburger DA. Quantitative aspects Principles of Tissue Engineering. 251-261. DOI: 10.1016/B978-012370615-7/50022-6  1
2007 Cassman M, Arkin A, Doyle F, Katagiri F, Lauffenburger D, Stokes C. Systems biology: International research and development Systems Biology: International Research and Development. 1-262. DOI: 10.1007/978-1-4020-5468-6  0.88
2007 Green JJ, Zugates GT, Tedford NC, Huang YH, Griffith LG, Lauffenburger DA, Sawicki JA, Langer R, Anderson DG. Combinatorial modification of degradable polymers enables transfection of human cells comparable to adenovirus Advanced Materials. 19: 2836-2842. DOI: 10.1002/Adma.200700371  1
2006 Aldridge BB, Haller G, Sorger PK, Lauffenburger DA. Direct Lyapunov exponent analysis enables parametric study of transient signalling governing cell behaviour. Systems Biology. 153: 425-32. PMID 17186704 DOI: 10.1049/ip-syb:20050065  1
2006 Aldridge BB, Burke JM, Lauffenburger DA, Sorger PK. Physicochemical modelling of cell signalling pathways. Nature Cell Biology. 8: 1195-203. PMID 17060902 DOI: 10.1038/ncb1497  1
2006 Albeck JG, MacBeath G, White FM, Sorger PK, Lauffenburger DA, Gaudet S. Collecting and organizing systematic sets of protein data. Nature Reviews. Molecular Cell Biology. 7: 803-12. PMID 17057751 DOI: 10.1038/Nrm2042  1
2006 Lauffenburger DA. Right on cue Nature Chemical Biology. 2: 569-570. PMID 17051228 DOI: 10.1038/nchembio1106-569  1
2006 Wolf-Yadlin A, Kumar N, Zhang Y, Hautaniemi S, Zaman M, Kim HD, Grantcharova V, Lauffenburger DA, White FM. Effects of HER2 overexpression on cell signaling networks governing proliferation and migration. Molecular Systems Biology. 2: 54. PMID 17016520 DOI: 10.1038/Msb4100094  1
2006 Hendriks BS, Cook J, Burke JM, Beusmans JM, Lauffenburger DA, de Graaf D. Computational modelling of ErbB family phosphorylation dynamics in response to transforming growth factor alpha and heregulin indicates spatial compartmentation of phosphatase activity Iee Proceedings Systems Biology. 153: 22-33. PMID 16983832 DOI: 10.1049/ip-syb:20050057  1
2006 Miller-Jensen K, Janes KA, Wong YL, Griffith LG, Lauffenburger DA. Adenoviral vector saturates Akt pro-survival signaling and blocks insulin-mediated rescue of tumor necrosis-factor-induced apoptosis. Journal of Cell Science. 119: 3788-98. PMID 16940353 DOI: 10.1242/Jcs.03102  1
2006 Kumar N, Hendriks BS, Janes KA, de Graaf D, Lauffenburger DA. Applying computational modeling to drug discovery and development. Drug Discovery Today. 11: 806-11. PMID 16935748 DOI: 10.1016/j.drudis.2006.07.010  1
2006 Hua F, Hautaniemi S, Yokoo R, Lauffenburger DA. Integrated mechanistic and data-driven modelling for multivariate analysis of signalling pathways Journal of the Royal Society Interface. 3: 515-526. PMID 16849248 DOI: 10.1098/rsif.2005.0109  1
2006 Zaman MH, Trapani LM, Sieminski AL, Siemeski A, Mackellar D, Gong H, Kamm RD, Wells A, Lauffenburger DA, Matsudaira P. Migration of tumor cells in 3D matrices is governed by matrix stiffness along with cell-matrix adhesion and proteolysis. Proceedings of the National Academy of Sciences of the United States of America. 103: 10889-94. PMID 16832052 DOI: 10.1073/Pnas.0604460103  1
2006 Kumar N, Zaman MH, Kim HD, Lauffenburger DA. A high-throughput migration assay reveals HER2-mediated cell migration arising from increased directional persistence. Biophysical Journal. 91: L32-4. PMID 16782798 DOI: 10.1529/Biophysj.106.088898  1
2006 Wells A, Harms B, Iwabu A, Koo L, Smith K, Griffith L, Lauffenburger DA. Motility signaled from the EGF receptor and related systems Methods in Molecular Biology (Clifton, N.J.). 327: 159-177. PMID 16780220 DOI: 10.1385/1-59745-012-X:159  1
2006 Smith KD, Wells A, Lauffenburger DA. Multiple signaling pathways mediate compaction of collagen matrices by EGF-stimulated fibroblasts Experimental Cell Research. 312: 1970-1982. PMID 16595133 DOI: 10.1016/J.Yexcr.2006.02.022  1
2006 Kharait S, Dhir R, Lauffenburger D, Wells A. Protein kinase Cdelta signaling downstream of the EGF receptor mediates migration and invasiveness of prostate cancer cells. Biochemical and Biophysical Research Communications. 343: 848-56. PMID 16564022 DOI: 10.1016/J.Bbrc.2006.03.044  0.4
2006 Janes KA, Gaudet S, Albeck JG, Nielsen UB, Lauffenburger DA, Sorger PK. The response of human epithelial cells to TNF involves an inducible autocrine cascade. Cell. 124: 1225-39. PMID 16564013 DOI: 10.1016/j.cell.2006.01.041  1
2006 Janes KA, Lauffenburger DA. A biological approach to computational models of proteomic networks. Current Opinion in Chemical Biology. 10: 73-80. PMID 16406679 DOI: 10.1016/j.cbpa.2005.12.016  1
2006 Semino CE, Kamm RD, Lauffenburger DA. Autocrine EGF receptor activation mediates endothelial cell migration and vascular morphogenesis induced by VEGF under interstitial flow Experimental Cell Research. 312: 289-298. PMID 16337626 DOI: 10.1016/J.Yexcr.2005.10.029  1
2005 Janes KA, Albeck JG, Gaudet S, Sorger PK, Lauffenburger DA, Yaffe MB. A systems model of signaling identifies a molecular basis set for cytokine-induced apoptosis. Science (New York, N.Y.). 310: 1646-53. PMID 16339439 DOI: 10.1126/Science.1116598  1
2005 Kamei DT, Lao BJ, Ricci MS, Deshpande R, Xu H, Tidor B, Lauffenburger DA. Quantitative methods for developing Fc mutants with extended half-lives Biotechnology and Bioengineering. 92: 748-760. PMID 16136591 DOI: 10.1002/Bit.20624  1
2005 Wells A, Huttenlocher A, Lauffenburger DA. Calpain proteases in cell adhesion and motility International Review of Cytology. 245: 1-16. PMID 16125543 DOI: 10.1016/S0074-7696(05)45001-9  1
2005 Rao BM, Driver I, Lauffenburger DA, Wittrup KD. High-affinity CD25-binding IL-2 mutants potently stimulate persistent T cell growth. Biochemistry. 44: 10696-701. PMID 16060678 DOI: 10.1021/Bi050436X  1
2005 Gaudet S, Janes KA, Albeck JG, Pace EA, Lauffenburger DA, Sorger PK. A compendium of signals and responses triggered by prodeath and prosurvival cytokines. Molecular & Cellular Proteomics : McP. 4: 1569-90. PMID 16030008 DOI: 10.1074/mcp.M500158-MCP200  1
2005 Yoshioka J, Prince RN, Huang H, Perkins SB, Cruz FU, MacGillivray C, Lauffenburger DA, Lee RT. Cardiomyocyte hypertrophy and degradation of connexin43 through spatially restricted autocrine/paracrine heparin-binding EGF. Proceedings of the National Academy of Sciences of the United States of America. 102: 10622-7. PMID 16020536 DOI: 10.1073/pnas.0501198102  1
2005 Hua F, Cornejo MG, Cardone MH, Stokes CL, Lauffenburger DA. Effects of Bcl-2 levels on Fas signaling-induced caspase-3 activation: molecular genetic tests of computational model predictions. Journal of Immunology (Baltimore, Md. : 1950). 175: 985-95. PMID 16002698  1
2005 Zhang Y, Wolf-Yadlin A, Ross PL, Pappin DJ, Rush J, Lauffenburger DA, White FM. Time-resolved mass spectrometry of tyrosine phosphorylation sites in the epidermal growth factor receptor signaling network reveals dynamic modules. Molecular & Cellular Proteomics : McP. 4: 1240-50. PMID 15951569 DOI: 10.1074/Mcp.M500089-Mcp200  1
2005 Zaman MH, Kamm RD, Matsudaira P, Lauffenburger DA. Computational model for cell migration in three-dimensional matrices. Biophysical Journal. 89: 1389-97. PMID 15908579 DOI: 10.1529/Biophysj.105.060723  1
2005 Viswanathan S, Davey RE, Cheng D, Raghu RC, Lauffenburger DA, Zandstra PW. Clonal evolution of stem and differentiated cells can be predicted by integrating cell-intrinsic and -extrinsic parameters. Biotechnology and Applied Biochemistry. 42: 119-31. PMID 15882145 DOI: 10.1042/Ba20040207  1
2005 Sachs K, Perez O, Pe'er D, Lauffenburger DA, Nolan GP. Causal protein-signaling networks derived from multiparameter single-cell data. Science (New York, N.Y.). 308: 523-9. PMID 15845847 DOI: 10.1126/Science.1105809  1
2005 Dong J, Opresko LK, Chrisler W, Orr G, Quesenberry RD, Lauffenburger DA, Wiley HS. The membrane-anchoring domain of epidermal growth factor receptor ligands dictates their ability to operate in juxtacrine mode. Molecular Biology of the Cell. 16: 2984-98. PMID 15829568 DOI: 10.1091/Mbc.E04-11-0994  1
2005 Varga CM, Tedford NC, Thomas M, Klibanov AM, Griffith LG, Lauffenburger DA. Quantitative comparison of polyethylenimine formulations and adenoviral vectors in terms of intracellular gene delivery processes. Gene Therapy. 12: 1023-32. PMID 15815703 DOI: 10.1038/Sj.Gt.3302495  1
2005 Shults MD, Janes KA, Lauffenburger DA, Imperiali B. A multiplexed homogeneous fluorescence-based assay for protein kinase activity in cell lysates. Nature Methods. 2: 277-83. PMID 15782220 DOI: 10.1038/Nmeth747  1
2005 Harms BD, Bassi GM, Horwitz AR, Lauffenburger DA. Directional persistence of EGF-induced cell migration is associated with stabilization of lamellipodial protrusions. Biophysical Journal. 88: 1479-88. PMID 15713602 DOI: 10.1529/Biophysj.104.047365  1
2005 Rao BM, Lauffenburger DA, Wittrup KD. Integrating cell-level kinetic modeling into the design of engineered protein therapeutics. Nature Biotechnology. 23: 191-4. PMID 15696150 DOI: 10.1038/Nbt1064  1
2005 Hautaniemi S, Kharait S, Iwabu A, Wells A, Lauffenburger DA. Modeling of signal-response cascades using decision tree analysis Bioinformatics. 21: 2027-2035. PMID 15657095 DOI: 10.1093/Bioinformatics/Bti278  1
2005 Monine MI, Berezhkovskii AM, Joslin EJ, Wiley HS, Lauffenburger DA, Shvartsman SY. Ligand accumulation in autocrine cell cultures. Biophysical Journal. 88: 2384-90. PMID 15653719 DOI: 10.1529/Biophysj.104.051425  1
2005 Hendriks BS, Orr G, Wells A, Wiley HS, Lauffenburger DA. Parsing ERK activation reveals quantitatively equivalent contributions from epidermal growth factor receptor and HER2 in human mammary epithelial cells. The Journal of Biological Chemistry. 280: 6157-69. PMID 15572377 DOI: 10.1074/Jbc.M410491200  0.6
2005 Woolf PJ, Prudhomme W, Daheron L, Daley GQ, Lauffenburger DA. Bayesian analysis of signaling networks governing embryonic stem cell fate decisions. Bioinformatics (Oxford, England). 21: 741-53. PMID 15479714 DOI: 10.1093/Bioinformatics/Bti056  1
2005 Lazzara MJ, Jasper P, Sorger P, Lauffenburger DA. Altered Egfr trafficking and signaling in iressa-sensitive human cell lines Aiche Annual Meeting, Conference Proceedings. 9238.  1
2004 Said MR, Begley TJ, Oppenheim AV, Lauffenburger DA, Samson LD. Global network analysis of phenotypic effects: protein networks and toxicity modulation in Saccharomyces cerevisiae. Proceedings of the National Academy of Sciences of the United States of America. 101: 18006-11. PMID 15608068 DOI: 10.1073/Pnas.0405996101  1
2004 Janes KA, Kelly JR, Gaudet S, Albeck JG, Sorger PK, Lauffenburger DA. Cue-signal-response analysis of TNF-induced apoptosis by partial least squares regression of dynamic multivariate data. Journal of Computational Biology : a Journal of Computational Molecular Cell Biology. 11: 544-61. PMID 15579231 DOI: 10.1089/1066527041887258  1
2004 Maly IV, Lee RT, Lauffenburger DA. A model for mechanotransduction in cardiac muscle: effects of extracellular matrix deformation on autocrine signaling. Annals of Biomedical Engineering. 32: 1319-35. PMID 15535051 DOI: 10.1114/B:Abme.0000042221.61633.23  1
2004 Lazar CS, Cresson CM, Lauffenburger DA, Gill GN. The Na+/H+ exchanger regulatory factor stabilizes epidermal growth factor receptors at the cell surface. Molecular Biology of the Cell. 15: 5470-80. PMID 15469991 DOI: 10.1091/mbc.E04-03-0239  1
2004 Rao BM, Driver I, Lauffenburger DA, Wittrup KD. Interleukin 2 (IL-2) variants engineered for increased IL-2 receptor alpha-subunit affinity exhibit increased potency arising from a cell surface ligand reservoir effect. Molecular Pharmacology. 66: 864-9. PMID 15385640 DOI: 10.1124/Mol.66.4.864  1
2004 Lu H, Koo LY, Wang WM, Lauffenburger DA, Griffith LG, Jensen KF. Microfluidic shear devices for quantitative analysis of cell adhesion. Analytical Chemistry. 76: 5257-64. PMID 15362881 DOI: 10.1021/Ac049837T  1
2004 Tschumperlin DJ, Dai G, Maly IV, Kikuchi T, Laiho LH, McVittie AK, Haley KJ, Lilly CM, So PT, Lauffenburger DA, Kamm RD, Drazen JM. Mechanotransduction through growth-factor shedding into the extracellular space. Nature. 429: 83-6. PMID 15103386 DOI: 10.1038/Nature02543  1
2004 Prudhomme W, Daley GQ, Zandstra P, Lauffenburger DA. Multivariate proteomic analysis of murine embryonic stem cell self-renewal versus differentiation signaling. Proceedings of the National Academy of Sciences of the United States of America. 101: 2900-5. PMID 14978270 DOI: 10.1073/Pnas.0308768101  0.32
2004 Iwabu A, Smith K, Allen FD, Lauffenburger DA, Wells A. Epidermal growth factor induces fibroblast contractility and motility via a protein kinase C delta-dependent pathway. The Journal of Biological Chemistry. 279: 14551-60. PMID 14747473 DOI: 10.1074/Jbc.M311981200  0.4
2004 Maly IV, Wiley HS, Lauffenburger DA. Self-organization of polarized cell signaling via autocrine circuits: computational model analysis. Biophysical Journal. 86: 10-22. PMID 14695245 DOI: 10.1016/S0006-3495(04)74079-5  1
2004 Shvartsman SY, Wiley HS, Lauffenburger DA. Epidermal growth factor receptor signaling in tissues Ieee Control Systems Magazine. 24: 53-61. DOI: 10.1109/Mcs.2004.1316653  1
2004 Sachs K, Perez OD, Pe'er D, Nolan GP, Gifford DK, Jaakkola TS, Lauffenburger DA. Analysis of signaling pathways in human T-cells using Bayesian network modeling of single cell data Proceedings - 2004 Ieee Computational Systems Bioinformatics Conference, Csb 2004. 644.  1
2003 Rao BM, Girvin AT, Ciardelli T, Lauffenburger DA, Wittrup KD. Interleukin-2 mutants with enhanced alpha-receptor subunit binding affinity. Protein Engineering. 16: 1081-7. PMID 14983090 DOI: 10.1093/Protein/Gzg111  1
2003 Viswanathan S, Benatar T, Mileikovsky M, Lauffenburger DA, Nagy A, Zandstra PW. Supplementation-dependent differences in the rates of embryonic stem cell self-renewal, differentiation, and apoptosis. Biotechnology and Bioengineering. 84: 505-17. PMID 14574685 DOI: 10.1002/Bit.10799  1
2003 Janes KA, Albeck JG, Peng LX, Sorger PK, Lauffenburger DA, Yaffe MB. A high-throughput quantitative multiplex kinase assay for monitoring information flow in signaling networks: application to sepsis-apoptosis. Molecular & Cellular Proteomics : McP. 2: 463-73. PMID 12832460 DOI: 10.1074/Mcp.M300045-Mcp200  1
2003 Sarkar CA, Lowenhaupt K, Wang PJ, Horan T, Lauffenburger DA. Parsing the effects of binding, signaling, and trafficking on the mitogenic potencies of granulocyte colony-stimulating factor analogues. Biotechnology Progress. 19: 955-64. PMID 12790662 DOI: 10.1021/Bp020017G  1
2003 Ideker T, Lauffenburger D. Building with a scaffold: emerging strategies for high- to low-level cellular modeling. Trends in Biotechnology. 21: 255-62. PMID 12788545 DOI: 10.1016/S0167-7799(03)00115-X  1
2003 Lauffenburger DA, Wells A. Quantitative parsing of cell multi-tasking in wound repair and tissue morphogenesis. Biophysical Journal. 84: 3499-500. PMID 12770862 DOI: 10.1016/S0006-3495(03)75084-X  0.4
2003 Ricci MS, Sarkar CA, Fallon EM, Lauffenburger DA, Brems DN. pH Dependence of structural stability of interleukin-2 and granulocyte colony-stimulating factor. Protein Science : a Publication of the Protein Society. 12: 1030-8. PMID 12717025 DOI: 10.1110/Ps.0230103  1
2003 Sarkar CA, Lauffenburger DA. Cell-level pharmacokinetic model of granulocyte colony-stimulating factor: implications for ligand lifetime and potency in vivo. Molecular Pharmacology. 63: 147-58. PMID 12488547 DOI: 10.1124/Mol.63.1.147  1
2003 Wiley HS, Shvartsman SY, Lauffenburger DA. Computational modeling of the EGF-receptor system: a paradigm for systems biology. Trends in Cell Biology. 13: 43-50. PMID 12480339 DOI: 10.1016/S0962-8924(02)00009-0  1
2003 Said MR, Oppenheim AV, Lauffenburger DA. Modeling cellular signal processing using interacting Markov chains Icassp, Ieee International Conference On Acoustics, Speech and Signal Processing - Proceedings. 6: 41-44.  1
2002 Sachs K, Gifford D, Jaakkola T, Sorger P, Lauffenburger DA. Bayesian network approach to cell signaling pathway modeling. Science's Stke : Signal Transduction Knowledge Environment. 2002: pe38. PMID 12209052 DOI: 10.1126/Stke.2002.148.Pe38  1
2002 Sarkar CA, Lowenhaupt K, Horan T, Boone TC, Tidor B, Lauffenburger DA. Rational cytokine design for increased lifetime and enhanced potency using pH-activated "histidine switching" Nature Biotechnology. 20: 908-913. PMID 12161759 DOI: 10.1038/Nbt725  1
2002 Wells A, Kassis J, Solava J, Turner T, Lauffenburger DA. Growth factor-induced cell motility in tumor invasion. Acta Oncologica (Stockholm, Sweden). 41: 124-30. PMID 12102155 DOI: 10.1080/028418602753669481  0.4
2002 Shvartsman SY, Muratov CB, Lauffenburger DA. Modeling and computational analysis of EGF receptor-mediated cell communication in Drosophila oogenesis. Development (Cambridge, England). 129: 2577-89. PMID 12015287  1
2002 Allen FD, Asnes CF, Chang P, Elson EL, Lauffenburger DA, Wells A. Epidermal growth factor induces acute matrix contraction and subsequent calpain-modulated relaxation. Wound Repair and Regeneration : Official Publication of the Wound Healing Society [and] the European Tissue Repair Society. 10: 67-76. PMID 11983008 DOI: 10.1046/J.1524-475X.2002.10701.X  1
2002 Viswanathan S, Benatar T, Rose-John S, Lauffenburger DA, Zandstra PW. Ligand/receptor signaling threshold (LIST) model accounts for gp130-mediated embryonic stem cell self-renewal responses to LIF and HIL-6. Stem Cells (Dayton, Ohio). 20: 119-38. PMID 11897869 DOI: 10.1634/Stemcells.20-2-119  1
2002 Koo LY, Irvine DJ, Mayes AM, Lauffenburger DA, Griffith LG. Co-regulation of cell adhesion by nanoscale RGD organization and mechanical stimulus. Journal of Cell Science. 115: 1423-33. PMID 11896190  1
2002 Glading A, Lauffenburger DA, Wells A. Cutting to the chase: calpain proteases in cell motility. Trends in Cell Biology. 12: 46-54. PMID 11854009 DOI: 10.1016/S0962-8924(01)02179-1  0.4
2002 Shvartsman SY, Hagan MP, Yacoub A, Dent P, Wiley HS, Lauffenburger DA. Autocrine loops with positive feedback enable context-dependent cell signaling. American Journal of Physiology. Cell Physiology. 282: C545-59. PMID 11832340 DOI: 10.1152/Ajpcell.00260.2001  1
2002 Kamei DT, Tidor B, Lauffenburger DA. Design of Fc-conjugated protein therapeutics using computational modeling of protein-protein interaction energetics Annual International Conference of the Ieee Engineering in Medicine and Biology - Proceedings. 1: 616.  1
2001 Varga CM, Hong K, Lauffenburger DA. Quantitative analysis of synthetic gene delivery vector design properties. Molecular Therapy : the Journal of the American Society of Gene Therapy. 4: 438-46. PMID 11708880 DOI: 10.1006/mthe.2001.0475  1
2001 Shvartsman SY, Wiley HS, Deen WM, Lauffenburger DA. Spatial range of autocrine signaling: modeling and computational analysis. Biophysical Journal. 81: 1854-67. PMID 11566760 DOI: 10.1016/S0006-3495(01)75837-7  1
2001 Narang A, Subramanian KK, Lauffenburger DA. A mathematical model for chemoattractant gradient sensing based on receptor-regulated membrane phospholipid signaling dynamics Annals of Biomedical Engineering. 29: 677-691. PMID 11556724 DOI: 10.1114/1.1385805  1
2001 Orsello CE, Lauffenburger DA, Hammer DA. Molecular properties in cell adhesion: a physical and engineering perspective. Trends in Biotechnology. 19: 310-6. PMID 11451473 DOI: 10.1016/S0167-7799(01)01692-4  0.96
2001 Lauffenburger DA, Wells A. Getting a grip: new insights for cell adhesion and traction. Nature Cell Biology. 3. PMID 11331893 DOI: 10.1038/35074631  0.4
2001 Kassis J, Lauffenburger DA, Turner T, Wells A. Tumor invasion as dysregulated cell motility Seminars in Cancer Biology. 11: 105-117. PMID 11322830 DOI: 10.1006/Scbi.2000.0362  0.4
2001 Glading A, Überall F, Keyse SM, Lauffenburger DA, Wells A. Membrane proximal ERK signaling is required for M-calpain activation downstream of epidermal growth factor receptor signaling. Journal of Biological Chemistry. 276: 23341-23348. PMID 11319218 DOI: 10.1074/Jbc.M008847200  0.4
2001 Asthagiri AR, Lauffenburger DA. A computational study of feedback effects on signal dynamics in a mitogen-activated protein kinase (MAPK) pathway model. Biotechnology Progress. 17: 227-39. PMID 11312698 DOI: 10.1021/Bp010009K  1
2001 Lauffenburger DA, Griffith LG. Who's got pull around here? Cell organization in development and tissue engineering. Proceedings of the National Academy of Sciences of the United States of America. 98: 4282-4. PMID 11296276 DOI: 10.1073/pnas.081083698  0.92
2000 Asthagiri AR, Lauffenburger DA. Bioengineering models of cell signaling. Annual Review of Biomedical Engineering. 2: 31-53. PMID 11701506 DOI: 10.1146/Annurev.Bioeng.2.1.31  1
2000 Schaffer DV, Lauffenburger DA. Targeted synthetic gene delivery vectors. Current Opinion in Molecular Therapeutics. 2: 155-61. PMID 11249636  1
2000 Varga CM, Wickham TJ, Lauffenburger DA. Receptor-mediated targeting of gene delivery vectors: insights from molecular mechanisms for improved vehicle design. Biotechnology and Bioengineering. 70: 593-605. PMID 11064328 DOI: 10.1002/1097-0290(20001220)70:6<593::AID-BIT1>3.0.CO;2-N  1
2000 Haugh JM, Wells A, Lauffenburger DA. Mathematical modeling of epidermal growth factor receptor signaling through the phospholipase C pathway: mechanistic insights and predictions for molecular interventions. Biotechnology and Bioengineering. 70: 225-38. PMID 10972934 DOI: 10.1002/1097-0290(20001020)70:2<225::Aid-Bit12>3.0.Co;2-S  1
2000 Zandstra PW, Lauffenburger DA, Eaves CJ. A ligand-receptor signaling threshold model of stem cell differentiation control: A biologically conserved mechanism applicable to hematopoiesis Blood. 96: 1215-1222. PMID 10942360 DOI: 10.1182/Blood.V96.4.1215.H8001215_1215_1222  1
2000 Zandstra PW, Le HV, Daley GQ, Griffith LG, Lauffenburger DA. Leukemia inhibitory factor (LIF) concentration modulates embryonic stem cell self-renewal and differentiation independently of proliferation. Biotechnology and Bioengineering. 69: 607-17. PMID 10918135 DOI: 10.1002/1097-0290(20000920)69:6<607::Aid-Bit4>3.0.Co;2-F  1
2000 Maheshwari G, Brown G, Lauffenburger DA, Wells A, Griffith LG. Cell adhesion and motility depend on nanoscale RGD clustering. Journal of Cell Science. 113: 1677-86. PMID 10769199  0.92
2000 Fallon EM, Liparoto SF, Lee KJ, Ciardelli TL, Lauffenburger DA. Increased endosomal sorting of ligand to recycling enhances potency of an interleukin-2 analog. The Journal of Biological Chemistry. 275: 6790-7. PMID 10702236 DOI: 10.1074/jbc.275.10.6790  1
2000 Schaffer DV, Fidelman NA, Dan N, Lauffenburger DA. Vector unpacking as a potential barrier for receptor-mediated polyplex gene delivery. Biotechnology and Bioengineering. 67: 598-606. PMID 10649234 DOI: 10.1002/(Sici)1097-0290(20000305)67:5<598::Aid-Bit10>3.0.Co;2-G  1
1999 Wells A, Ware MF, Allen FD, Lauffenburger DA. Shaping up for shipping out: PLC? signaling of morphology changes in EGF-stimulated fibroblast migration Cytoskeleton. 44: 227-233. PMID 10602252 DOI: 10.1002/(Sici)1097-0169(199912)44:4<227::Aid-Cm1>3.0.Co;2-B  0.4
1999 Haugh JM, Huang AC, Wiley HS, Wells A, Lauffenburger DA. Internalized epidermal growth factor receptors participate in the activation of p21(ras) in fibroblasts. The Journal of Biological Chemistry. 274: 34350-60. PMID 10567412 DOI: 10.1074/Jbc.274.48.34350  1
1999 Asthagiri AR, Nelson CM, Horwitz AF, Lauffenburger DA. Quantitative relationship among integrin-ligand binding, adhesion, and signaling via focal adhesion kinase and extracellular signal-regulated kinase 2. The Journal of Biological Chemistry. 274: 27119-27. PMID 10480927 DOI: 10.1074/Jbc.274.38.27119  1
1999 Zhang S, Yan L, Altman M, Lässle M, Nugent H, Frankel F, Lauffenburger DA, Whitesides GM, Rich A. Biological surface engineering: a simple system for cell pattern formation. Biomaterials. 20: 1213-20. PMID 10395390 DOI: 10.1016/S0142-9612(99)00014-9  1
1999 Lauffenburger DA, Schaffer DV. The matrix delivers. Nature Medicine. 5: 733-4. PMID 10395312 DOI: 10.1038/10451  1
1999 Maheshwari G, Wells A, Griffith LG, Lauffenburger DA. Biophysical integration of effects of epidermal growth factor and fibronectin on fibroblast migration. Biophysical Journal. 76: 2814-23. PMID 10233097 DOI: 10.1016/S0006-3495(99)77435-7  0.92
1999 Asthagiri AR, Horwitz AF, Lauffenburger DA. A rapid and sensitive quantitative kinase activity assay using a convenient 96-well format. Analytical Biochemistry. 269: 342-7. PMID 10222008 DOI: 10.1006/Abio.1999.4055  1
1999 Palecek SP, Horwitz AF, Lauffenburger DA. Kinetic Model for Integrin-mediated Adhesion Release during Cell Migration Annals of Biomedical Engineering. 27: 219-235. PMID 10199699  1
1999 Haugh JM, Schooler K, Wells A, Wiley HS, Lauffenburger DA. Effect of epidermal growth factor receptor internalization on regulation of the phospholipase C-gamma1 signaling pathway. The Journal of Biological Chemistry. 274: 8958-65. PMID 10085141 DOI: 10.1074/Jbc.274.13.8958  1
1999 Palecek SP, Cox EA, Huttenlocher A, Lauffenburger DA, Horwitz AF. Integrin Adhesion in Cell Migration Advances in Molecular and Cell Biology. 28: 367-388. DOI: 10.1016/S1569-2558(08)60054-5  1
1998 Reddy CC, Wells A, Lauffenburger DA. Comparative mitogenic potencies of EGF and TGFα and their dependence on receptor-limitation versus ligand-limitation Medical & Biological Engineering & Computing. 36: 499-507. PMID 10198537 DOI: 10.1007/Bf02523222  0.4
1998 Wiley HS, Woolf MF, Opresko LK, Burke PM, Will B, Morgan JR, Lauffenburger DA. Removal of the membrane-anchoring domain of epidermal growth factor leads to intracrine signaling and disruption of mammary epithelial cell organization Journal of Cell Biology. 143: 1317-1328. PMID 9832559 DOI: 10.1083/jcb.143.5.1317  1
1998 Haugh JM, Lauffenburger DA. Analysis of receptor internalization as a mechanism for modulating signal transduction. Journal of Theoretical Biology. 195: 187-218. PMID 9822563 DOI: 10.1006/Jtbi.1998.0791  1
1998 Lauffenburger DA, Fallon EM, Haugh JM. Scratching the (cell) surface: cytokine engineering for improved ligand/receptor trafficking dynamics. Chemistry & Biology. 5: R257-63. PMID 9818145 DOI: 10.1016/S1074-5521(98)90110-7  1
1998 Schaffer DV, Lauffenburger DA. Optimization of cell surface binding enhances efficiency and specificity of molecular conjugate gene delivery. The Journal of Biological Chemistry. 273: 28004-9. PMID 9774415 DOI: 10.1074/Jbc.273.43.28004  1
1997 Huttenlocher A, Palecek SP, Lu Q, Zhang W, Mellgren RL, Lauffenburger DA, Ginsberg MH, Horwitz AF. Regulation of cell migration by the calcium-dependent protease calpain Journal of Biological Chemistry. 272: 32719-32722. PMID 9407041 DOI: 10.1074/Jbc.272.52.32719  1
1997 Ware MF, Tice DA, Parsons SJ, Lauffenburger DA. Overexpression of cellular src in fibroblasts enhances endocytic internalization of epidermal growth factor receptor Journal of Biological Chemistry. 272: 30185-30190. PMID 9374500 DOI: 10.1074/jbc.272.48.30185  1
1997 Kuo SC, Hammer DA, Lauffenburger DA. Simulation of detachment of specifically bound particles from surfaces by shear flow. Biophysical Journal. 73: 517-31. PMID 9199814 DOI: 10.1016/S0006-3495(97)78090-1  0.96
1997 Haugh JM, Lauffenburger DA. Physical modulation of intracellular signaling processes by locational regulation. Biophysical Journal. 72: 2014-31. PMID 9129805 DOI: 10.1016/S0006-3495(97)78846-5  1
1997 Palecek SP, Loftust JC, Ginsberg MH, Lauffenburger DA, Horwitz AF. Integrin-ligand binding properties govern cell migration speed through cell-substratum adhesiveness Nature. 385: 537-540. PMID 9020360 DOI: 10.1038/385537A0  1
1997 Schaffer DV, Neve RL, Lauffenburger DA. Use of the green fluorescent protein as a quantitative reporter of epidermal growth factor receptor-mediated gene delivery Tissue Engineering. 3: 53-63. DOI: 10.1089/Ten.1997.3.53  1
1996 Lauffenburger DA, Chu L, French A, Oehrtman G, Reddy C, Wells A, Niyogi S, Wiley HS. Engineering dynamics of growth factors and other therapeutic ligands Biotechnology and Bioengineering. 52: 61-80. PMID 18629852 DOI: 10.1002/(Sici)1097-0290(19961005)52:1<61::Aid-Bit6>3.0.Co;2-X  0.6
1996 Reddy CC, Wells A, Lauffenburger DA. Receptor-mediated effects on ligand availability influence relative mitogenic potencies of epidermal growth factor and transforming growth factor α Journal of Cellular Physiology. 166: 512-522. PMID 8600155 DOI: 10.1002/(Sici)1097-4652(199603)166:3<512::Aid-Jcp6>3.0.Co;2-S  0.4
1995 Schmidt CE, Dai J, Lauffenburger DA, Sheetz MP, Horwitz AF. Integrin-cytoskeletal interactions in neuronal growth cones Journal of Neuroscience. 15: 3400-3407. PMID 7751919  1
1995 Lauffenburger DA, Forsten KE, Will B, Wiley HS. Molecular/cell engineering approach to autocrine ligand control of cell function. Annals of Biomedical Engineering. 23: 208-15. PMID 7631977 DOI: 10.1007/BF02584423  1
1994 Forsten KE, Lauffenburger DA. Probability of autocrine ligand capture by cell-surface receptors: implications for ligand secretion measurements. Journal of Computational Biology : a Journal of Computational Molecular Cell Biology. 1: 15-23. PMID 8790450 DOI: 10.1089/cmb.1994.1.15  1
1994 Wu P, Hoying JB, Williams SK, Kozikowski BA, Lauffenburger DA. Integrin-binding peptide in solution inhibits or enhances endothelial cell migration, predictably from cell adhesion. Annals of Biomedical Engineering. 22: 144-52. PMID 8074327 DOI: 10.1007/Bf02390372  1
1994 Forsten KE, Lauffenburger DA. The role of low-affinity interleukin-2 receptors in autocrine ligand binding: alternative mechanisms for enhanced binding effect. Molecular Immunology. 31: 739-51. PMID 8035836 DOI: 10.1016/0161-5890(94)90148-1  1
1994 Reddy CC, Wells A, Lauffenburger DA. Proliferative response of fibroblasts expressing internalization-deficient epidermal growth factor (EGF) receptors is altered via differential EGF depletion effect. Biotechnology Progress. 10: 377-384. PMID 7765094 DOI: 10.1021/Bp00028A006  0.4
1994 Schmidt CE, Chen T, Lauffenburger DA. Simulation of integrin-cytoskeletal interactions in migrating fibroblasts Biophysical Journal. 67: 461-474. PMID 7522599 DOI: 10.1016/S0006-3495(94)80502-8  1
1994 Linderman JJ, Mahama PA, Forsten KE, Lauffenburger DA. Diffusion and Probability in Receptor Binding and Signaling Advances in Chemical Engineering. 19: 51-127. DOI: 10.1016/S0065-2377(08)60213-6  1
1994 Forsten KE, Kozack RE, Lauffenburger DA, Subramaniam S. Numerical solution of the nonlinear Poisson-Boltzmann equation for a membrane-electrolyte system Journal of Physical Chemistry. 98: 5580-5586.  1
1993 Nunez M, Mayo KH, Starbuck C, Lauffenburger D. pH sensitivity of epidermal growth factor receptor complexes Journal of Cellular Biochemistry. 51: 312-321. PMID 8501133  1
1993 Saterbak A, Kuo SC, Lauffenburger DA. Heterogeneity and probabilistic binding contributions to receptor-mediated cell detachment kinetics Biophysical Journal. 65: 243-252. PMID 8396454 DOI: 10.1016/S0006-3495(93)81077-4  1
1993 DiMilla PA, Stone JA, Quinn JA, Albelda SM, Lauffenburger DA. Maximal migration of human smooth muscle cells on fibronectin and type IV collagen occurs at an intermediate attachment strength. The Journal of Cell Biology. 122: 729-37. PMID 8335696 DOI: 10.1083/Jcb.122.3.729  1
1993 Kuo SC, Lauffenburger DA. Relationship between receptor/ligand binding affinity and adhesion strength Biophysical Journal. 65: 2191-2200. PMID 8298043 DOI: 10.1016/S0006-3495(93)81277-3  1
1993 Schmidt CE, Horwitz AF, Lauffenburger DA, Sheetz MP. Integrin-cytoskeletal interactions in migrating fibroblasts are dynamic, asymmetric, and regulated Journal of Cell Biology. 123: 977-991. PMID 8227153 DOI: 10.1083/Jcb.123.4.977  1
1992 Ford RM, Lauffenburger DA. A simple expression for quantifying bacterial chemotaxis using capillary assay data: application to the analysis of enhanced chemotactic responses from growth-limited cultures. Mathematical Biosciences. 109: 127-49. PMID 1600283 DOI: 10.1016/0025-5564(92)90042-U  1
1992 Forsten KE, Lauffenburger DA. Interrupting autocrine ligand-receptor binding: comparison between receptor blockers and ligand decoys. Biophysical Journal. 63: 857-61. PMID 1330038 DOI: 10.1016/S0006-3495(92)81661-2  1
1992 Forsten KE, Lauffenburger DA. Autocrine ligand binding to cell receptors. Mathematical analysis of competition by solution "decoys". Biophysical Journal. 61: 518-29. PMID 1312367 DOI: 10.1016/S0006-3495(92)81856-8  1
1992 DiMilla PA, Quinn JA, Albelda SM, Lauffenburger DA. Measurement of individual cell migration parameters for human tissue cells Aiche Journal. 38: 1092-1104. DOI: 10.1002/Aic.690380712  1
1991 Ford RM, Phillips BR, Quinn JA, Lauffenburger DA. Stopped-flow chamber and image analysis system for quantitative characterization of bacterial population migration: Motility and chemotaxis ofEscherichia coli K12 to fucose. Microbial Ecology. 22: 127-38. PMID 24194332 DOI: 10.1007/Bf02540219  1
1991 Ford RM, Lauffenburger DA. Measurement of bacterial random motility and chemotaxis coefficients: II. Application of single-cell-based mathematical model. Biotechnology and Bioengineering. 37: 661-72. PMID 18600657 DOI: 10.1002/bit.260370708  1
1991 Ford RM, Phillips BR, Quinn JA, Lauffenburger DA. Measurement of bacterial random motility and chemotaxis coefficients: I. Stopped-flow diffusion chamber assay. Biotechnology and Bioengineering. 37: 647-60. PMID 18600656 DOI: 10.1002/Bit.260370707  1
1991 Ford RM, Lauffenburger DA. Analysis of chemotactic bacterial distributions in population migration assays using a mathematical model applicable to steep or shallow attractant gradients. Bulletin of Mathematical Biology. 53: 721-49. PMID 1933037 DOI: 10.1007/BF02461551  1
1991 Charnick SB, Fisher ES, Lauffenburger DA. Computer simulations of cell-target encounter including biased cell motion toward targets: Single and multiple cell-target simulations in two dimensions Bulletin of Mathematical Biology. 53: 591-621. PMID 1933031 DOI: 10.1007/BF02458631  1
1991 Cano ML, Lauffenburger DA, Zigmond SH. Kinetic analysis of F-actin depolymerization in polymorphonuclear leukocyte lysates indicates that chemoattractant stimulation increases actin filament number without altering the filament length distribution. The Journal of Cell Biology. 115: 677-87. PMID 1918158 DOI: 10.1083/Jcb.115.3.677  1
1991 DiMilla PA, Barbee K, Lauffenburger DA. Mathematical model for the effects of adhesion and mechanics on cell migration speed. Biophysical Journal. 60: 15-37. PMID 1883934 DOI: 10.1016/S0006-3495(91)82027-6  1
1991 Stokes CL, Lauffenburger DA. Analysis of the roles of microvessel endothelial cell random motility and chemotaxis in angiogenesis Journal of Theoretical Biology. 152: 377-403. PMID 1721100 DOI: 10.1016/S0022-5193(05)80201-2  1
1991 Wiley HS, Herbst JJ, Walsh BJ, Lauffenburger DA, Rosenfeld MG, Gill GN. The role of tyrosine kinase activity in endocytosis, compartmentation, and down-regulation of the epidermal growth factor receptor. The Journal of Biological Chemistry. 266: 11083-94. PMID 1645724  0.88
1990 Wattenbarger MR, Graves DJ, Lauffenburger DA. Specific adhesion of glycophorin liposomes to a lectin surface in shear flow Biophysical Journal. 57: 765-777. PMID 2344463 DOI: 10.1016/S0006-3495(90)82597-2  1
1990 Cozens-Roberts C, Quinn JA, Lauffenburger DA. Receptor-mediated cell attachment and detachment kinetics. II. Experimental model studies with the radial-flow detachment assay. Biophysical Journal. 58: 857-72. PMID 2174272 DOI: 10.1016/S0006-3495(90)82431-0  1
1990 Cozens-Roberts C, Lauffenburger DA, Quinn JA. Receptor-mediated cell attachment and detachment kinetics. I. Probabilistic model and analysis. Biophysical Journal. 58: 841-56. PMID 2174271 DOI: 10.1016/S0006-3495(90)82430-9  1
1990 Fisher ES, Lauffenburger DA. Analysis of the effects of immune cell motility and chemotaxis on target elimination dynamics Mathematical Biosciences. 98: 73-102. PMID 2134499 DOI: 10.1016/0025-5564(90)90012-N  1
1990 Stokes CL, Weisz PB, Williams SK, Lauffenburger DA. Inhibition of microvascular endothelial cell migration by beta-cyclodextrin tetradecasulfate and hydrocortisone. Microvascular Research. 40: 279-84. PMID 1701207 DOI: 10.1016/0026-2862(90)90025-M  1
1989 Buettner HM, Lauffenburger DA, Zigmond SH. Measurement of leukocyte motility and chemotaxis parameters with the Millipore filter assay. Journal of Immunological Methods. 123: 25-37. PMID 2794528 DOI: 10.1016/0022-1759(89)90026-4  1
1989 Glasgow JE, Farrell BE, Fisher ES, Lauffenburger DA, Daniele RP. The motile response of alveolar macrophages. An experimental study using single-cell and cell population approaches. The American Review of Respiratory Disease. 139: 320-9. PMID 2643900 DOI: 10.1164/ajrccm/139.2.320  1
1989 Hammer DA, Lauffenburger DA. A dynamical model for receptor-mediated cell adhesion to surfaces in viscous shear flow. Cell Biophysics. 14: 139-73. PMID 2472206 DOI: 10.1007/BF02797131  1
1989 Tranquillo RT, Fisher ES, Farrell BE, Lauffenburger DA. A stochastic model for chemosensory cell movement: application to neutrophil and macrophage persistence and orientation Mathematical and Computer Modelling. 12: 1179. DOI: 10.1016/0025-5564(88)90071-5  1
1989 Rivero MA, Tranquillo RT, Buettner HM, Lauffenburger DA. Transport models for chemotactic cell populations based on individual cell behavior Chemical Engineering Science. 44: 2881-2897. DOI: 10.1016/0009-2509(89)85098-5  1
1988 Tranquillo RT, Lauffenburger DA, Zigmond SH. A stochastic model for leukocyte random motility and chemotaxis based on receptor binding fluctuations. The Journal of Cell Biology. 106: 303-9. PMID 3339093 DOI: 10.1083/Jcb.106.2.303  1
1988 Lauffenburger DA, Tranquillo RT, Zigmond SH. Concentration gradients of chemotactic factors in chemotaxis assays. Methods in Enzymology. 162: 85-101. PMID 3226329 DOI: 10.1016/0076-6879(88)62067-2  1
1988 Tranquillo RT, Zigmond SH, Lauffenburger DA. Measurement of the chemotaxis coefficient for human neutrophils in the under-agarose migration assay. Cell Motility and the Cytoskeleton. 11: 1-15. PMID 3208295 DOI: 10.1002/Cm.970110102  1
1988 Fisher ES, Lauffenburger DA, Daniele RP. The effect of alveolar macrophage chemotaxis on bacterial clearance from the lung surface American Review of Respiratory Disease. 137: 1129-1134. PMID 3195812 DOI: 10.1164/AJRCCM/137.5.1129  1
1988 Linderman JJ, Lauffenburger DA. Analysis of intracellular receptor/ligand sorting in endosomes. Journal of Theoretical Biology. 132: 203-45. PMID 2850411 DOI: 10.1016/S0022-5193(88)80157-7  0.96
1987 Tranquillo RT, Lauffenburger DA. Stochastic model of leukocyte chemosensory movement Journal of Mathematical Biology. 25: 229-262. PMID 3625051 DOI: 10.1007/Bf00276435  1
1987 Fisher ES, Lauffenburger DA. Mathematical analysis of cell-target encounter rates in two dimensions. The effect of chemotaxis Biophysical Journal. 51: 705-716. PMID 3593868  1
1987 Lauffenburger DA, Linderman J, Berkowitz L. Analysis of mammalian cell growth factor receptor dynamics. Annals of the New York Academy of Sciences. 506: 147-62. PMID 3324852 DOI: 10.1111/j.1749-6632.1987.tb23816.x  0.96
1987 Hammer DA, Lauffenburger DA. A dynamical model for receptor-mediated cell adhesion to surfaces. Biophysical Journal. 52: 475-87. PMID 2820521 DOI: 10.1016/S0006-3495(87)83236-8  1
1987 Hammer DA, Linderman JJ, Graves DJ, Lauffenburger DA. Affinity Chromatography for Cell Separation: Mathematical Model and Experimental Analysis Biotechnology Progress. 3: 189-204. DOI: 10.1002/Btpr.5420030310  1
1986 Linderman JJ, Lauffenburger DA. Analysis of intracellular receptor/ligand sorting. Calculation of mean surface and bulk diffusion times within a sphere. Biophysical Journal. 50: 295-305. PMID 3741985  0.96
1986 Zigmond SH, Lauffenburger DA. Assays of leukocyte chemotaxis. Annual Review of Medicine. 37: 149-55. PMID 3010803 DOI: 10.1146/annurev.me.37.020186.001053  1
1986 Tranquillo RT, Lauffenburger DA. Consequences of chemosensory phenomena for leukocyte chemotactic orientation Cell Biophysics. 8: 1-46. PMID 2421906 DOI: 10.1007/BF02788459  1
1985 Hertz CM, Graves DJ, Lauffenburger DA, Serota FT. Use of cell affinity chromatography for separation of lymphocyte subpopulations. Biotechnology and Bioengineering. 27: 603-12. PMID 18553715 DOI: 10.1002/bit.260270509  1
1984 Stickle DF, Lauffenburger DA, Zigmond SH. Measurement of chemoattractant concentration profiles and diffusion coefficient in agarose. Journal of Immunological Methods. 70: 65-74. PMID 6546944 DOI: 10.1016/0022-1759(84)90390-9  1
1984 Lauffenburger D, Grady M, Keller KH. An hypothesis for approaching swarms of myxobacteria Journal of Theoretical Biology. 110: 257-274. DOI: 10.1016/S0022-5193(84)80058-2  1
1983 Daukas G, Lauffenburger DA, Zigmond S. Reversible pinocytosis in polymorphonuclear leukocytes Journal of Cell Biology. 96: 1642-1650. PMID 6304114 DOI: 10.1083/Jcb.96.6.1642  1
1982 Lauffenburger D, Aris R, Keller K. Effects of cell motility and chemotaxis on microbial population growth. Biophysical Journal. 40: 209-19. PMID 7183335 DOI: 10.1016/S0006-3495(82)84476-7  1
1982 Zigmond SH, Sullivan SJ, Lauffenburger DA. Kinetic analysis of chemotactic peptide receptor modulation. The Journal of Cell Biology. 92: 34-43. PMID 6276415 DOI: 10.1083/Jcb.92.1.34  1
1981 Lauffenburger D, Aris R, Keller KH. Effects of random motility on growth of bacterial populations. Microbial Ecology. 7: 207-27. PMID 24227496 DOI: 10.1007/Bf02010304  1
1981 Lauffenburger DA, Zigmond SH. Chemotactic factor concentration gradients in chemotaxis assay systems. Journal of Immunological Methods. 40: 45-60. PMID 7205000 DOI: 10.1016/0022-1759(81)90079-X  1
1979 Lauffenburger D, Keller KH. Effects of leukocyte random motility and chemotaxis in tissue inflammatory response. Journal of Theoretical Biology. 81: 475-503. PMID 395370 DOI: 10.1016/0022-5193(79)90047-X  1
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