Leonard Guarente - Publications

Massachusetts Institute of Technology, Cambridge, MA, United States 

212 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2017 Ondracek CR, Frappier V, Ringel AE, Wolberger C, Guarente L. Mutations that Allow SIR2 Orthologs to Function in a NAD(+)-Depleted Environment. Cell Reports. 18: 2310-2319. PMID 28273448 DOI: 10.1016/j.celrep.2017.02.031  0.44
2015 Chalkiadaki A, Guarente L. The multifaceted functions of sirtuins in cancer. Nature Reviews. Cancer. 15: 608-24. PMID 26383140 DOI: 10.1038/nrc3985  1
2014 Guarente L. Linking DNA damage, NAD(+)/SIRT1, and aging. Cell Metabolism. 20: 706-7. PMID 25440052 DOI: 10.1016/j.cmet.2014.10.015  1
2014 Guarente L. Aging research-where do we stand and where are we going? Cell. 159: 15-9. PMID 25259916 DOI: 10.1016/j.cell.2014.08.041  1
2014 Bell EL, Nagamori I, Williams EO, Del Rosario AM, Bryson BD, Watson N, White FM, Sassone-Corsi P, Guarente L. SirT1 is required in the male germ cell for differentiation and fecundity in mice. Development (Cambridge, England). 141: 3495-504. PMID 25142464 DOI: 10.1242/dev.110627  1
2014 Imai S, Guarente L. NAD+ and sirtuins in aging and disease. Trends in Cell Biology. 24: 464-71. PMID 24786309 DOI: 10.1016/j.tcb.2014.04.002  1
2014 Yao H, Sundar IK, Ahmad T, Lerner C, Gerloff J, Friedman AE, Phipps RP, Sime PJ, McBurney MW, Guarente L, Rahman I. SIRT1 protects against cigarette smoke-induced lung oxidative stress via a FOXO3-dependent mechanism. American Journal of Physiology. Lung Cellular and Molecular Physiology. 306: L816-28. PMID 24633890 DOI: 10.1152/ajplung.00323.2013  1
2014 Herskovits AZ, Guarente L. SIRT1 in neurodevelopment and brain senescence. Neuron. 81: 471-83. PMID 24507186 DOI: 10.1016/j.neuron.2014.01.028  1
2014 Chang HC, Guarente L. SIRT1 and other sirtuins in metabolism. Trends in Endocrinology and Metabolism: Tem. 25: 138-45. PMID 24388149 DOI: 10.1016/j.tem.2013.12.001  1
2014 Li Y, Wong K, Giles A, Jiang J, Lee JW, Adams AC, Kharitonenkov A, Yang Q, Gao B, Guarente L, Zang M. Hepatic SIRT1 attenuates hepatic steatosis and controls energy balance in mice by inducing fibroblast growth factor 21. Gastroenterology. 146: 539-49.e7. PMID 24184811 DOI: 10.1053/j.gastro.2013.10.059  1
2013 Crotty Alexander LE, Marsh BJ, Timmer AM, Lin AE, Zainabadi K, Czopik A, Guarente L, Nizet V. Myeloid cell sirtuin-1 expression does not alter host immune responses to Gram-negative endotoxemia or Gram-positive bacterial infection. Plos One. 8: e84481. PMID 24386389 DOI: 10.1371/journal.pone.0084481  1
2013 Hasegawa K, Wakino S, Simic P, Sakamaki Y, Minakuchi H, Fujimura K, Hosoya K, Komatsu M, Kaneko Y, Kanda T, Kubota E, Tokuyama H, Hayashi K, Guarente L, Itoh H. Renal tubular sirt1 attenuates diabetic albuminuria by epigenetically suppressing claudin-1 overexpression in podocytes Nature Medicine. 19: 1496-1504. PMID 24141423 DOI: 10.1038/nm.3363  1
2013 Guarente L. Calorie restriction and sirtuins revisited. Genes & Development. 27: 2072-85. PMID 24115767 DOI: 10.1101/gad.227439.113  1
2013 Yao H, Hwang JW, Sundar IK, Friedman AE, McBurney MW, Guarente L, Gu W, Kinnula VL, Rahman I. SIRT1 redresses the imbalance of tissue inhibitor of matrix metalloproteinase-1 and matrix metalloproteinase-9 in the development of mouse emphysema and human COPD. American Journal of Physiology. Lung Cellular and Molecular Physiology. 305: L615-24. PMID 24039251 DOI: 10.1152/ajplung.00249.2012  1
2013 Guarente L. Introduction: sirtuins in aging and diseases. Methods in Molecular Biology (Clifton, N.J.). 1077: 3-10. PMID 24014396 DOI: 10.1007/978-1-62703-637-5_1  1
2013 Guarente L. Sirtuins and ageing--new findings. Embo Reports. 14: 750. PMID 23928812 DOI: 10.1038/embor.2013.121  1
2013 Fendt SM, Bell EL, Keibler MA, Olenchock BA, Mayers JR, Wasylenko TM, Vokes NI, Guarente L, Vander Heiden MG, Stephanopoulos G. Reductive glutamine metabolism is a function of the α-ketoglutarate to citrate ratio in cells. Nature Communications. 4: 2236. PMID 23900562 DOI: 10.1038/ncomms3236  1
2013 Mouchiroud L, Houtkooper RH, Moullan N, Katsyuba E, Ryu D, Cantó C, Mottis A, Jo YS, Viswanathan M, Schoonjans K, Guarente L, Auwerx J. The NAD(+)/Sirtuin Pathway Modulates Longevity through Activation of Mitochondrial UPR and FOXO Signaling. Cell. 154: 430-41. PMID 23870130 DOI: 10.1016/j.cell.2013.06.016  1
2013 Chang HC, Guarente L. SIRT1 mediates central circadian control in the SCN by a mechanism that decays with aging. Cell. 153: 1448-60. PMID 23791176 DOI: 10.1016/j.cell.2013.05.027  1
2013 Herskovits AZ, Guarente L. Sirtuin deacetylases in neurodegenerative diseases of aging. Cell Research. 23: 746-58. PMID 23689277 DOI: 10.1038/cr.2013.70  1
2013 Fendt SM, Bell EL, Keibler MA, Davidson SM, Wirth GJ, Fiske B, Mayers JR, Schwab M, Bellinger G, Csibi A, Patnaik A, Blouin MJ, Cantley LC, Guarente L, Blenis J, et al. Metformin decreases glucose oxidation and increases the dependency of prostate cancer cells on reductive glutamine metabolism. Cancer Research. 73: 4429-38. PMID 23687346 DOI: 10.1158/0008-5472.CAN-13-0080  1
2013 Simic P, Williams EO, Bell EL, Gong JJ, Bonkowski M, Guarente L. SIRT1 suppresses the epithelial-to-mesenchymal transition in cancer metastasis and organ fibrosis. Cell Reports. 3: 1175-86. PMID 23583181 DOI: 10.1016/j.celrep.2013.03.019  1
2013 Simic P, Zainabadi K, Bell E, Sykes DB, Saez B, Lotinun S, Baron R, Scadden D, Schipani E, Guarente L. SIRT1 regulates differentiation of mesenchymal stem cells by deacetylating β-catenin. Embo Molecular Medicine. 5: 430-40. PMID 23364955 DOI: 10.1002/emmm.201201606  1
2013 Libert S, Guarente L. Metabolic and neuropsychiatric effects of calorie restriction and sirtuins. Annual Review of Physiology. 75: 669-84. PMID 23043250 DOI: 10.1146/annurev-physiol-030212-183800  1
2013 Simic P, Zainabadi K, Bell E, Sykes DB, Saez B, Lotinun S, Baron R, Scadden D, Schipani E, Guarente L. Corrigendum to SIRT1 regulates differentiation of mesenchymal stem cells by deacetylating β-catenin [EMBO Mol Med] DOI:10.1002/emmm.201201606 Embo Molecular Medicine. 5: 482. DOI: 10.1002/emmm.201390004  1
2012 Chalkiadaki A, Guarente L. High-fat diet triggers inflammation-induced cleavage of SIRT1 in adipose tissue to promote metabolic dysfunction. Cell Metabolism. 16: 180-8. PMID 22883230 DOI: 10.1016/j.cmet.2012.07.003  1
2012 Barzilai N, Guarente L, Kirkwood TB, Partridge L, Rando TA, Slagboom PE. The place of genetics in ageing research. Nature Reviews. Genetics. 13: 589-94. PMID 22777128 DOI: 10.1038/nrg3290  1
2012 Libert S, Bonkowski MS, Pointer K, Pletcher SD, Guarente L. Deviation of innate circadian period from 24 h reduces longevity in mice. Aging Cell. 11: 794-800. PMID 22702406 DOI: 10.1111/j.1474-9726.2012.00846.x  1
2012 Yao H, Chung S, Hwang JW, Rajendrasozhan S, Sundar IK, Dean DA, McBurney MW, Guarente L, Gu W, Rönty M, Kinnula VL, Rahman I. SIRT1 protects against emphysema via FOXO3-mediated reduction of premature senescence in mice. The Journal of Clinical Investigation. 122: 2032-45. PMID 22546858 DOI: 10.1172/JCI60132  1
2012 Guarente L. Sirtuins and calorie restriction. Nature Reviews. Molecular Cell Biology. 13: 207. PMID 22374145 DOI: 10.1038/nrm3308  1
2012 Chalkiadaki A, Guarente L. Sirtuins mediate mammalian metabolic responses to nutrient availability. Nature Reviews. Endocrinology. 8: 287-96. PMID 22249520 DOI: 10.1038/nrendo.2011.225  1
2012 Donmez G, Arun A, Chung CY, McLean PJ, Lindquist S, Guarente L. SIRT1 protects against α-synuclein aggregation by activating molecular chaperones. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 32: 124-32. PMID 22219275 DOI: 10.1523/JNEUROSCI.3442-11.2012  1
2012 Jeong H, Cohen DE, Cui L, Supinski A, Savas JN, Mazzulli JR, Yates JR, Bordone L, Guarente L, Krainc D. Sirt1 mediates neuroprotection from mutant huntingtin by activation of the TORC1 and CREB transcriptional pathway. Nature Medicine. 18: 159-65. PMID 22179316 DOI: 10.1038/nm.2559  1
2012 Metallo CM, Gameiro PA, Bell EL, Mattaini KR, Yang J, Hiller K, Jewell CM, Johnson ZR, Irvine DJ, Guarente L, Kelleher JK, Vander Heiden MG, Iliopoulos O, Stephanopoulos G. Reductive glutamine metabolism by IDH1 mediates lipogenesis under hypoxia Nature. 481: 380-384. PMID 22101433 DOI: 10.1038/nature10602  1
2012 Guarente L, Baur JA, Mai A. Revelations into resveratrol's mechanism Nature Medicine. 18: 500-501. DOI: 10.1038/nm.2727  1
2012 Becker DM, Guarente L. Protocol for High-Efficiency Yeast Transformation Guide to Electroporation and Electrofusion. 501-505. DOI: 10.1016/B978-0-08-091727-6.50034-4  1
2011 Libert S, Pointer K, Bell EL, Das A, Cohen DE, Asara JM, Kapur K, Bergmann S, Preisig M, Otowa T, Kendler KS, Chen X, Hettema JM, van den Oord EJ, Rubio JP, ... Guarente L, et al. SIRT1 activates MAO-A in the brain to mediate anxiety and exploratory drive. Cell. 147: 1459-72. PMID 22169038 DOI: 10.1016/j.cell.2011.10.054  1
2011 Guarente L. Sirtuins, aging, and metabolism. Cold Spring Harbor Symposia On Quantitative Biology. 76: 81-90. PMID 22114328 DOI: 10.1101/sqb.2011.76.010629  1
2011 Chalkiadaki A, Guarente L. Metabolic signals regulate SIRT1 expression. Embo Reports. 12: 985-6. PMID 21941300 DOI: 10.1038/embor.2011.179  1
2011 Viswanathan M, Guarente L. Regulation of Caenorhabditis elegans lifespan by sir-2.1 transgenes. Nature. 477: E1-2. PMID 21938026 DOI: 10.1038/nature10440  1
2011 Nadtochiy SM, Yao H, McBurney MW, Gu W, Guarente L, Rahman I, Brookes PS. SIRT1-mediated acute cardioprotection. American Journal of Physiology. Heart and Circulatory Physiology. 301: H1506-12. PMID 21856913 DOI: 10.1152/ajpheart.00587.2011  1
2011 Guarente L. The logic linking protein acetylation and metabolism. Cell Metabolism. 14: 151-3. PMID 21803285 DOI: 10.1016/j.cmet.2011.07.007  1
2011 Bell EL, Guarente L. The SirT3 divining rod points to oxidative stress. Molecular Cell. 42: 561-8. PMID 21658599 DOI: 10.1016/j.molcel.2011.05.008  1
2011 Guarente L. Franklin H. Epstein Lecture: Sirtuins, aging, and medicine. The New England Journal of Medicine. 364: 2235-44. PMID 21651395 DOI: 10.1056/NEJMra1100831  1
2011 Nakagawa T, Guarente L. Sirtuins at a glance. Journal of Cell Science. 124: 833-8. PMID 21378304 DOI: 10.1242/jcs.081067  1
2011 Bell EL, Emerling BM, Ricoult SJ, Guarente L. SirT3 suppresses hypoxia inducible factor 1α and tumor growth by inhibiting mitochondrial ROS production. Oncogene. 30: 2986-96. PMID 21358671 DOI: 10.1038/onc.2011.37  1
2011 Li Y, Xu S, Giles A, Nakamura K, Lee JW, Hou X, Donmez G, Li J, Luo Z, Walsh K, Guarente L, Zang M. Hepatic overexpression of SIRT1 in mice attenuates endoplasmic reticulum stress and insulin resistance in the liver. Faseb Journal : Official Publication of the Federation of American Societies For Experimental Biology. 25: 1664-79. PMID 21321189 DOI: 10.1096/fj.10-173492  1
2011 Guarente L. Connecting the Dots: Linking Sirtuins and AMPK in Metabolism and Aging Developmental Cell. 20: e1. DOI: 10.1016/j.devcel.2011.04.004  1
2010 Zhang Z, Lowry SF, Guarente L, Haimovich B. Roles of SIRT1 in the acute and restorative phases following induction of inflammation. The Journal of Biological Chemistry. 285: 41391-401. PMID 20966076 DOI: 10.1074/jbc.M110.174482  1
2010 Baur JA, Chen D, Chini EN, Chua K, Cohen HY, de Cabo R, Deng C, Dimmeler S, Gius D, Guarente LP, Helfand SL, Imai S, Itoh H, Kadowaki T, Koya D, et al. Dietary restriction: standing up for sirtuins. Science (New York, N.Y.). 329: 1012-3; author reply. PMID 20798296 DOI: 10.1126/science.329.5995.1012  1
2010 Akieda-Asai S, Zaima N, Ikegami K, Kahyo T, Yao I, Hatanaka T, Iemura S, Sugiyama R, Yokozeki T, Eishi Y, Koike M, Ikeda K, Chiba T, Yamaza H, Shimokawa I, ... ... Guarente L, et al. SIRT1 Regulates Thyroid-Stimulating Hormone Release by Enhancing PIP5Kgamma Activity through Deacetylation of Specific Lysine Residues in Mammals. Plos One. 5: e11755. PMID 20668706 DOI: 10.1371/journal.pone.0011755  1
2010 Donmez G, Wang D, Cohen DE, Guarente L. SIRT1 suppresses beta-amyloid production by activating the alpha-secretase gene ADAM10. Cell. 142: 320-32. PMID 20655472 DOI: 10.1016/j.cell.2010.06.020  1
2010 Berdichevsky A, Guarente L, Bose A. Acute oxidative stress can reverse insulin resistance by inactivation of cytoplasmic JNK. The Journal of Biological Chemistry. 285: 21581-9. PMID 20430894 DOI: 10.1074/jbc.M109.093633  1
2010 Donmez G, Guarente L. Aging and disease: connections to sirtuins. Aging Cell. 9: 285-90. PMID 20409078 DOI: 10.1111/j.1474-9726.2010.00548.x  1
2010 Imai S, Guarente L. Ten years of NAD-dependent SIR2 family deacetylases: implications for metabolic diseases. Trends in Pharmacological Sciences. 31: 212-20. PMID 20226541 DOI: 10.1016/j.tips.2010.02.003  1
2010 Guarente L. Forever young. Cell. 140: 176-8. PMID 20141830 DOI: 10.1016/j.cell.2010.01.015  1
2009 Nakagawa T, Guarente L. Urea cycle regulation by mitochondrial sirtuin, SIRT5. Aging. 1: 578-81. PMID 20157539  1
2009 Cohen DE, Supinski AM, Bonkowski MS, Donmez G, Guarente LP. Neuronal SIRT1 regulates endocrine and behavioral responses to calorie restriction. Genes & Development. 23: 2812-7. PMID 20008932 DOI: 10.1101/gad.1839209  1
2009 Nakagawa T, Lomb DJ, Haigis MC, Guarente L. SIRT5 Deacetylates carbamoyl phosphate synthetase 1 and regulates the urea cycle. Cell. 137: 560-70. PMID 19410549 DOI: 10.1016/j.cell.2009.02.026  1
2009 Blander G, Bhimavarapu A, Mammone T, Maes D, Elliston K, Reich C, Matsui MS, Guarente L, Loureiro JJ. SIRT1 promotes differentiation of normal human keratinocytes. The Journal of Investigative Dermatology. 129: 41-9. PMID 18563176 DOI: 10.1038/jid.2008.179  1
2008 Liu Y, Dentin R, Chen D, Hedrick S, Ravnskjaer K, Schenk S, Milne J, Meyers DJ, Cole P, Yates J, Olefsky J, Guarente L, Montminy M. A fasting inducible switch modulates gluconeogenesis via activator/coactivator exchange. Nature. 456: 269-73. PMID 18849969 DOI: 10.1038/nature07349  1
2008 Chen D, Steele AD, Hutter G, Bruno J, Govindarajan A, Easlon E, Lin SJ, Aguzzi A, Lindquist S, Guarente L. The role of calorie restriction and SIRT1 in prion-mediated neurodegeneration. Experimental Gerontology. 43: 1086-93. PMID 18799131 DOI: 10.1016/j.exger.2008.08.050  1
2008 Nakahata Y, Kaluzova M, Grimaldi B, Sahar S, Hirayama J, Chen D, Guarente LP, Sassone-Corsi P. The NAD+-dependent deacetylase SIRT1 modulates CLOCK-mediated chromatin remodeling and circadian control. Cell. 134: 329-40. PMID 18662547 DOI: 10.1016/j.cell.2008.07.002  1
2008 Chen D, Bruno J, Easlon E, Lin SJ, Cheng HL, Alt FW, Guarente L. Tissue-specific regulation of SIRT1 by calorie restriction. Genes & Development. 22: 1753-7. PMID 18550784 DOI: 10.1101/gad.1650608  1
2008 Firestein R, Blander G, Michan S, Oberdoerffer P, Ogino S, Campbell J, Bhimavarapu A, Luikenhuis S, de Cabo R, Fuchs C, Hahn WC, Guarente LP, Sinclair DA. The SIRT1 deacetylase suppresses intestinal tumorigenesis and colon cancer growth. Plos One. 3: e2020. PMID 18414679 DOI: 10.1371/journal.pone.0002020  1
2008 Libert S, Cohen D, Guarente L. Neurogenesis directed by Sirt1. Nature Cell Biology. 10: 373-4. PMID 18379594 DOI: 10.1038/ncb0408-373  1
2008 Guarente L. Mitochondria--a nexus for aging, calorie restriction, and sirtuins? Cell. 132: 171-6. PMID 18243090 DOI: 10.1016/j.cell.2008.01.007  1
2007 Guarente L. Sirtuins in aging and disease. Cold Spring Harbor Symposia On Quantitative Biology. 72: 483-8. PMID 18419308 DOI: 10.1101/sqb.2007.72.024  1
2007 Westphal CH, Dipp MA, Guarente L. A therapeutic role for sirtuins in diseases of aging? Trends in Biochemical Sciences. 32: 555-60. PMID 17980602 DOI: 10.1016/j.tibs.2007.09.008  1
2007 Li X, Zhang S, Blander G, Tse JG, Krieger M, Guarente L. SIRT1 deacetylates and positively regulates the nuclear receptor LXR. Molecular Cell. 28: 91-106. PMID 17936707 DOI: 10.1016/j.molcel.2007.07.032  1
2007 Lombard DB, Alt FW, Cheng HL, Bunkenborg J, Streeper RS, Mostoslavsky R, Kim J, Yancopoulos G, Valenzuela D, Murphy A, Yang Y, Chen Y, Hirschey MD, Bronson RT, Haigis M, ... Guarente LP, et al. Mammalian Sir2 homolog SIRT3 regulates global mitochondrial lysine acetylation. Molecular and Cellular Biology. 27: 8807-14. PMID 17923681 DOI: 10.1128/MCB.01636-07  1
2007 Bordone L, Guarente L. Sirtuins and beta-cell function. Diabetes, Obesity & Metabolism. 9: 23-7. PMID 17919175 DOI: 10.1111/j.1463-1326.2007.00769.x  1
2007 Bishop NA, Guarente L. Genetic links between diet and lifespan: shared mechanisms from yeast to humans. Nature Reviews. Genetics. 8: 835-44. PMID 17909538 DOI: 10.1038/nrg2188  1
2007 Bordone L, Cohen D, Robinson A, Motta MC, van Veen E, Czopik A, Steele AD, Crowe H, Marmor S, Luo J, Gu W, Guarente L. SIRT1 transgenic mice show phenotypes resembling calorie restriction. Aging Cell. 6: 759-67. PMID 17877786 DOI: 10.1111/j.1474-9726.2007.00335.x  1
2007 Bishop NA, Guarente L. Two neurons mediate diet-restriction-induced longevity in C. elegans. Nature. 447: 545-9. PMID 17538612 DOI: 10.1038/nature05904  1
2007 Chen D, Guarente L. SIR2: a potential target for calorie restriction mimetics. Trends in Molecular Medicine. 13: 64-71. PMID 17207661 DOI: 10.1016/j.molmed.2006.12.004  1
2007 Kume S, Haneda M, Kanasaki K, Sugimoto T, Araki S, Isshiki K, Isono M, Uzu T, Guarente L, Kashiwagi A, Koya D. SIRT1 inhibits transforming growth factor beta-induced apoptosis in glomerular mesangial cells via Smad7 deacetylation. The Journal of Biological Chemistry. 282: 151-8. PMID 17098745 DOI: 10.1074/jbc.M605904200  1
2006 Berdichevsky A, Guarente L. A stress response pathway involving sirtuins, forkheads and 14-3-3 proteins. Cell Cycle (Georgetown, Tex.). 5: 2588-91. PMID 17172829  1
2006 Guarente L. Sirtuins as potential targets for metabolic syndrome. Nature. 444: 868-74. PMID 17167475 DOI: 10.1038/nature05486  1
2006 Haigis MC, Guarente LP. Mammalian sirtuins--emerging roles in physiology, aging, and calorie restriction. Genes & Development. 20: 2913-21. PMID 17079682 DOI: 10.1101/gad.1467506  1
2006 Haigis MC, Mostoslavsky R, Haigis KM, Fahie K, Christodoulou DC, Murphy AJ, Valenzuela DM, Yancopoulos GD, Karow M, Blander G, Wolberger C, Prolla TA, Weindruch R, Alt FW, Guarente L. SIRT4 inhibits glutamate dehydrogenase and opposes the effects of calorie restriction in pancreatic beta cells. Cell. 126: 941-54. PMID 16959573 DOI: 10.1016/j.cell.2006.06.057  1
2006 Ford E, Voit R, Liszt G, Magin C, Grummt I, Guarente L. Mammalian Sir2 homolog SIRT7 is an activator of RNA polymerase I transcription. Genes & Development. 20: 1075-80. PMID 16618798 DOI: 10.1101/gad.1399706  1
2006 Sinclair DA, Lin SJ, Guarente L. Life-span extension in yeast. Science (New York, N.Y.). 312: 195-7; author reply . PMID 16614198 DOI: 10.1126/science.312.5771.195d  1
2006 Lin SJ, Guarente L. Increased life span due to calorie restriction in respiratory-deficient yeast. Plos Genetics. 2: e33; author reply e3. PMID 16596163 DOI: 10.1371/journal.pgen.0020033  1
2006 Mostoslavsky R, Chua KF, Lombard DB, Pang WW, Fischer MR, Gellon L, Liu P, Mostoslavsky G, Franco S, Murphy MM, Mills KD, Patel P, Hsu JT, Hong AL, Ford E, ... ... Guarente L, et al. Genomic instability and aging-like phenotype in the absence of mammalian SIRT6. Cell. 124: 315-29. PMID 16439206 DOI: 10.1016/j.cell.2005.11.044  1
2006 Bordone L, Motta MC, Picard F, Robinson A, Jhala US, Apfeld J, McDonagh T, Lemieux M, McBurney M, Szilvasi A, Easlon EJ, Lin SJ, Guarente L. Sirt1 regulates insulin secretion by repressing UCP2 in pancreatic beta cells. Plos Biology. 4: e31. PMID 16366736 DOI: 10.1371/journal.pbio.0040031  1
2005 Guarente L. NO link between calorie restriction and mitochondria. Nature Chemical Biology. 1: 355-6. PMID 16370369 DOI: 10.1038/nchembio1205-355  1
2005 Chen D, Steele AD, Lindquist S, Guarente L. Increase in activity during calorie restriction requires Sirt1. Science (New York, N.Y.). 310: 1641. PMID 16339438 DOI: 10.1126/science.1118357  1
2005 Warner H, Anderson J, Austad S, Bergamini E, Bredesen D, Butler R, Carnes BA, Clark BF, Cristofalo V, Faulkner J, Guarente L, Harrison DE, Kirkwood T, Lithgow G, Martin G, et al. Science fact and the SENS agenda. What can we reasonably expect from ageing research? Embo Reports. 6: 1006-8. PMID 16264422 DOI: 10.1038/sj.embor.7400555  1
2005 Viswanathan M, Kim SK, Berdichevsky A, Guarente L. A role for SIR-2.1 regulation of ER stress response genes in determining C. elegans life span. Developmental Cell. 9: 605-15. PMID 16256736 DOI: 10.1016/j.devcel.2005.09.017  1
2005 Guarente L. Calorie restriction and SIR2 genes--towards a mechanism. Mechanisms of Ageing and Development. 126: 923-8. PMID 15941577 DOI: 10.1016/j.mad.2005.03.013  1
2005 Marciniak RA, Cavazos D, Montellano R, Chen Q, Guarente L, Johnson FB. A novel telomere structure in a human alternative lengthening of telomeres cell line. Cancer Research. 65: 2730-7. PMID 15805272 DOI: 10.1158/0008-5472.CAN-04-2888  1
2005 Liszt G, Ford E, Kurtev M, Guarente L. Mouse Sir2 homolog SIRT6 is a nuclear ADP-ribosyltransferase. The Journal of Biological Chemistry. 280: 21313-20. PMID 15795229 DOI: 10.1074/jbc.M413296200  1
2005 Bordone L, Guarente L. Calorie restriction, SIRT1 and metabolism: understanding longevity. Nature Reviews. Molecular Cell Biology. 6: 298-305. PMID 15768047 DOI: 10.1038/nrm1616  1
2005 Guarente L, Picard F. Calorie restriction--the SIR2 connection. Cell. 120: 473-82. PMID 15734680 DOI: 10.1016/j.cell.2005.01.029  1
2005 Picard F, Guarente L. Molecular links between aging and adipose tissue International Journal of Obesity. 29: S36-S39. PMID 15711582 DOI: 10.1038/sj.ijo.0802912  1
2005 Blander G, Olejnik J, Krzymanska-Olejnik E, McDonagh T, Haigis M, Yaffe MB, Guarente L. SIRT1 shows no substrate specificity in vitro Journal of Biological Chemistry. 280: 9780-9785. PMID 15640142 DOI: 10.1074/jbc.M414080200  1
2004 Du X, Shen J, Kugan N, Furth EE, Lombard DB, Cheung C, Pak S, Luo G, Pignolo RJ, DePinho RA, Guarente L, Johnson FB. Telomere shortening exposes functions for the mouse Werner and Bloom syndrome genes. Molecular and Cellular Biology. 24: 8437-46. PMID 15367665 DOI: 10.1128/MCB.24.19.8437-8446.2004  1
2004 Leissring MA, Farris W, Wu X, Christodoulou DC, Haigis MC, Guarente L, Selkoe DJ. Alternative translation initiation generates a novel isoform of insulin-degrading enzyme targeted to mitochondria. The Biochemical Journal. 383: 439-46. PMID 15285718 DOI: 10.1042/BJ20041081  1
2004 Chang S, Multani AS, Cabrera NG, Naylor ML, Laud P, Lombard D, Pathak S, Guarente L, DePinho RA. Essential role of limiting telomeres in the pathogenesis of Werner syndrome. Nature Genetics. 36: 877-82. PMID 15235603 DOI: 10.1038/ng1389  1
2004 Blander G, Guarente L. The Sir2 family of protein deacetylases Annual Review of Biochemistry. 73: 417-435. PMID 15189148 DOI: 10.1146/annurev.biochem.73.011303.073651  1
2004 Picard F, Kurtev M, Chung N, Topark-Ngarm A, Senawong T, Machado De Oliveira R, Leid M, McBurney MW, Guarente L. Sirt1 promotes fat mobilization in white adipocytes by repressing PPAR-gamma. Nature. 429: 771-6. PMID 15175761 DOI: 10.1038/nature02583  1
2004 Kaeberlein M, Andalis AA, Liszt GB, Fink GR, Guarente L. Saccharomyces cerevisiae SSD1-V confers longevity by a Sir2p-independent mechanism. Genetics. 166: 1661-72. PMID 15126388 DOI: 10.1534/genetics.166.4.1661  1
2004 Motta MC, Divecha N, Lemieux M, Kamel C, Chen D, Gu W, Bultsma Y, McBurney M, Guarente L. Mammalian SIRT1 Represses Forkhead Transcription Factors Cell. 116: 551-563. PMID 14980222 DOI: 10.1016/S0092-8674(04)00126-6  1
2004 Lin SJ, Ford E, Haigis M, Liszt G, Guarente L. Calorie restriction extends yeast life span by lowering the level of NADH. Genes & Development. 18: 12-6. PMID 14724176 DOI: 10.1101/gad.1164804  1
2004 Guarente LP. Forestalling the great beyond with the help of SIR2 Scientist. 18: 34-35.  1
2003 Blander G, De Oliveira RM, Conboy CM, Haigis M, Guarente L. Superoxide dismutase 1 knock-down induces senescence in human fibroblasts Journal of Biological Chemistry. 278: 38966-38969. PMID 12871978 DOI: 10.1074/jbc.M307146200  1
2003 Lin SJ, Guarente L. Nicotinamide adenine dinucleotide, a metabolic regulator of transcription, longevity and disease. Current Opinion in Cell Biology. 15: 241-6. PMID 12648681 DOI: 10.1016/S0955-0674(03)00006-1  1
2003 Hekimi S, Guarente L. Genetics and the specificity of the aging process Science. 299: 1351-1354. PMID 12610295 DOI: 10.1126/science.1082358  1
2003 Koubova J, Guarente L. How does calorie restriction work? Genes and Development. 17: 313-321. PMID 12569120 DOI: 10.1101/gad.1052903  1
2002 Kaeberlein M, Andalis AA, Fink GR, Guarente L. High osmolarity extends life span in Saccharomyces cerevisiae by a mechanism related to calorie restriction. Molecular and Cellular Biology. 22: 8056-66. PMID 12391171 DOI: 10.1128/MCB.22.22.8056-8066.2002  1
2002 Lin SJ, Kaeberlein M, Andalis AA, Sturtz LA, Defossez PA, Culotta VC, Fink GR, Guarente L. Calorie restriction extends Saccharomyces cerevisiae lifespan by increasing respiration. Nature. 418: 344-8. PMID 12124627 DOI: 10.1038/nature00829  1
2002 Park PU, McVey M, Guarente L. Separation of mother and daughter cells. Methods in Enzymology. 351: 468-77. PMID 12073364 DOI: 10.1016/S0076-6879(02)51865-6  1
2002 Armstrong CM, Kaeberlein M, Imai SI, Guarente L. Mutations in Saccharomyces cerevisiae gene SIR2 can have differential effects on in vivo silencing phenotypes and in vitro histone deacetylation activity. Molecular Biology of the Cell. 13: 1427-38. PMID 11950950 DOI: 10.1091/mbc.01-10-0482  1
2002 Kaeberlein M, Guarente L. Saccharomyces cerevisiae MPT5 and SSD1 function in parallel pathways to promote cell wall integrity Genetics. 160: 83-95. PMID 11805047  1
2002 Tissenbaum HA, Guarente L. Model organisms as a guide to mammalian aging Developmental Cell. 2: 9-19. PMID 11782310 DOI: 10.1016/S1534-5807(01)00098-3  1
2001 Vaziri H, Dessain SK, Eaton EN, Imai SI, Frye RA, Pandita TK, Guarente L, Weinberg RA. hSIR2SIRT1 functions as an NAD-dependent p53 deacetylase Cell. 107: 149-159. PMID 11672523 DOI: 10.1016/S0092-8674(01)00527-X  1
2001 Luo J, Nikolaev AY, Imai S, Chen D, Su F, Shiloh A, Guarente L, Gu W. Negative control of p53 by Sir2alpha promotes cell survival under stress. Cell. 107: 137-48. PMID 11672522 DOI: 10.1016/S0092-8674(01)00524-4  1
2001 Marciniak R, Guarente L. Human genetics: Testing telomerase Nature. 413: 370-373. PMID 11574867 DOI: 10.1038/35096663  1
2001 Guarente L. SIR2 and aging - The exception that proves the rule Trends in Genetics. 17: 391-392. PMID 11418219 DOI: 10.1016/S0168-9525(01)02339-3  1
2001 Hu P, Beresten SF, van Brabant AJ, Ye TZ, Pandolfi PP, Johnson FB, Guarente L, Ellis NA. Evidence for BLM and Topoisomerase IIIalpha interaction in genomic stability. Human Molecular Genetics. 10: 1287-98. PMID 11406610 DOI: 10.1093/hmg/10.12.1287  1
2001 McVey M, Kaeberlein M, Tissenbaum HA, Guarente L. The short life span of Saccharomyces cerevisiae sgs1 and srs2 mutants is a composite of normal aging processes and mitotic arrest due to defective recombination. Genetics. 157: 1531-42. PMID 11290710  1
2001 Tissenbaum HA, Guarente L. Increased dosage of a sir-2 gene extends lifespan in Caenorhabditis elegans Nature. 410: 227-230. PMID 11242085 DOI: 10.1038/35065638  1
2001 Johnson FB, Marciniak RA, McVey M, Stewart SA, Hahn WC, Guarente L. The Saccharomyces cerevisiae WRN homolog Sgs1p participates in telomere maintenance in cells lacking telomerase. The Embo Journal. 20: 905-13. PMID 11179234 DOI: 10.1093/emboj/20.4.905  1
2001 Guarente L, Glaser V. An interview with Leonard Guarente, Ph.D Journal of Anti-Aging Medicine. 4: 9-12.  1
2000 Guarente L, Kenyon C. Genetic pathways that regulate ageing in model organisms. Nature. 408: 255-62. PMID 11089983 DOI: 10.1038/35041700  1
2000 Lin SJ, Defossez PA, Guarente L. Requirement of NAD and SIR2 for life-span extension by calorie restriction in saccharomyces cerevisiae Science. 289: 2126-2128. PMID 11000115 DOI: 10.1126/science.289.5487.2126  1
2000 Lombard DB, Guarente L. Nijmegen breakage syndrome disease protein and MRE11 at PML nuclear bodies and meiotic telomeres Cancer Research. 60: 2331-2334. PMID 10811102  1
2000 Guarente L. Sir2 links chromatin silencing, metabolism, and aging Genes and Development. 14: 1021-1026. PMID 10809662  1
2000 Marciniak RA, Johnson FB, Guarente L. Dyskeratosis congenita, telomeres and human ageing. Trends in Genetics : Tig. 16: 193-5. PMID 10782108 DOI: 10.1016/S0168-9525(00)01984-3  1
2000 Yankiwski V, Marciniak RA, Guarente L, Neff NF. Nuclear structure in normal and Bloom syndrome cells Proceedings of the National Academy of Sciences of the United States of America. 97: 5214-5219. PMID 10779560 DOI: 10.1073/pnas.090525897  1
2000 Lombard DB, Beard C, Johnson B, Marciniak RA, Dausman J, Bronson R, Buhlmann JE, Lipman R, Curry R, Sharpe A, Jaenisch R, Guarente L. Mutations in the WRN gene in mice accelerate mortality in a p53-null background. Molecular and Cellular Biology. 20: 3286-91. PMID 10757812 DOI: 10.1128/MCB.20.9.3286-3291.2000  1
2000 Johnson FB, Lombard DB, Neff NF, Mastrangelo MA, Dewolf W, Ellis NA, Marciniak RA, Yin Y, Jaenisch R, Guarente L. Association of the Bloom syndrome protein with topoisomerase IIIalpha in somatic and meiotic cells. Cancer Research. 60: 1162-7. PMID 10728666  1
2000 Imai S, Armstrong CM, Kaeberlein M, Guarente L. Transcriptional silencing and longevity protein Sir2 is an NAD-dependent histone deacetylase. Nature. 403: 795-800. PMID 10693811 DOI: 10.1038/35001622  1
2000 Tissenbaum HA, Hawdon J, Perregaux M, Hotez P, Guarente L, Ruvkun G. A common muscarinic pathway for diapause recovery in the distantly related nematode species Caenorhabditis elegans and Ancylostoma caninum. Proceedings of the National Academy of Sciences of the United States of America. 97: 460-5. PMID 10618440 DOI: 10.1073/pnas.97.1.460  1
2000 Guarente L, Silver PA. Nucleus and gene expression: Function following form in the nucleus Current Opinion in Cell Biology. 12: 279. DOI: 10.1016/S0955-0674(00)00088-0  1
1999 Guarente L. Mutant mice live longer Nature. 402: 243+245. PMID 10580490 DOI: 10.1038/46185  1
1999 Guarente L. Diverse and dynamic functions of the Sir silencing complex Nature Genetics. 23: 281-285. PMID 10545947 DOI: 10.1038/15458  1
1999 Kaeberlein M, McVey M, Guarente L. The SIR2/3/4 complex and SIR2 alone promote longevity in Saccharomyces cerevisiae by two different mechanisms. Genes & Development. 13: 2570-80. PMID 10521401 DOI: 10.1101/gad.13.19.2570  1
1999 Ashrafi K, Sinclair D, Gordon JI, Guarente L. Passage through stationary phase advances replicative aging in Saccharomyces cerevisiae. Proceedings of the National Academy of Sciences of the United States of America. 96: 9100-5. PMID 10430902 DOI: 10.1073/pnas.96.16.9100  1
1999 Mills KD, Sinclair DA, Guarente L. MEC1-dependent redistribution of the Sir3 silencing protein from telomeres to DNA double-strand breaks. Cell. 97: 609-20. PMID 10367890 DOI: 10.1016/S0092-8674(00)80772-2  1
1999 Defossez PA, Prusty R, Kaeberlein M, Lin SJ, Ferrigno P, Silver PA, Keil RL, Guarente L. Elimination of replication block protein Fob1 extends the life span of yeast mother cells Molecular Cell. 3: 447-455. PMID 10230397 DOI: 10.1016/S1097-2765(00)80472-4  1
1999 Park PU, Defossez PA, Guarente L. Effects of mutations in DNA repair genes on formation of ribosomal DNA circles and life span in Saccharomyces cerevisiae Molecular and Cellular Biology. 19: 3848-3856. PMID 10207108  1
1999 Johnson FB, Sinclair DA, Guarente L. Molecular biology of aging. Cell. 96: 291-302. PMID 9988222 DOI: 10.1016/S0092-8674(00)80567-X  1
1999 King DA, Zhang L, Guarente L, Marmorstein R. Structure of a HAP1-DNA complex reveals dramatically asymmetric DNA binding by a homodimeric protein. Nature Structural Biology. 6: 64-71. PMID 9886294 DOI: 10.1038/4940  1
1999 King DA, Zhang L, Guarente L, Marmorstein R. Structure of HAP1-18-DNA implicates direct allosteric effect of protein-DNA interactions on transcriptional activation. Nature Structural Biology. 6: 22-7. PMID 9886287 DOI: 10.1038/4893  1
1998 Defossez PA, Park PU, Guarente L. Vicious circles: A mechanism for yeast aging Current Opinion in Microbiology. 1: 707-711. PMID 10066542  1
1998 Sinclair D, Mills K, Guarente L. Aging in Saccharomyces cerevisiae Annual Review of Microbiology. 52: 533-560. PMID 9891807 DOI: 10.1146/annurev.micro.52.1.533  1
1998 Guarente L, Ruvkun G, Amasino R. Aging, life span, and senescence. Proceedings of the National Academy of Sciences of the United States of America. 95: 11034-6. PMID 9736682 DOI: 10.1073/pnas.95.19.11034  1
1998 Johnson FB, Marciniak RA, Guarente L. Telomeres, the nucleolus and aging. Current Opinion in Cell Biology. 10: 332-8. PMID 9640533 DOI: 10.1016/S0955-0674(98)80008-2  1
1998 Marciniak RA, Lombard DB, Johnson FB, Guarente L. Nucleolar localization of the Werner syndrome protein in human cells. Proceedings of the National Academy of Sciences of the United States of America. 95: 6887-92. PMID 9618508 DOI: 10.1073/pnas.95.12.6887  1
1998 Sinclair DA, Mills K, Guarente L. Molecular mechanisms of yeast aging Trends in Biochemical Sciences. 23: 131-134. PMID 9584615 DOI: 10.1016/S0968-0004(98)01188-8  1
1997 Guarente L. Chromatin and ageing in yeast and in mammals Ciba Foundation Symposia. 104-111. PMID 9524753  1
1997 Sinclair DA, Guarente L. Extrachromosomal rDNA circles - A cause of aging in yeast Cell. 91: 1033-1042. PMID 9428525 DOI: 10.1016/S0092-8674(00)80493-6  1
1997 Mcnabb DS, Tseng KAS, Guarente L. The Saccharomyces cerevisiae Hap5p homolog from fission yeast reveals two conserved domains that are essential for assembly of heterotetrameric CCAAT-binding factor Molecular and Cellular Biology. 17: 7008-7018. PMID 9372932  1
1997 Guarente L. Link between aging and the nucleolus Genes and Development. 11: 2449-2455. PMID 9334311  1
1997 Austriaco NR, Guarente LP. Changes of telomere length cause reciprocal changes in the lifespan of mother cells in Saccharomyces cerevisiae Proceedings of the National Academy of Sciences of the United States of America. 94: 9768-9772. PMID 9275199 DOI: 10.1073/pnas.94.18.9768  1
1997 Sinclair DA, Mills K, Guarente L. Accelerated aging and nucleolar fragmentation in yeast SGS1 mutants Science. 277: 1313-1316. PMID 9271578 DOI: 10.1126/science.277.5330.1313  1
1997 McNabb DS, Pak SM, Guarente L. Cassette for the generation of sequential gene disruptions in the yeast Schizosaccharomyces pombe Biotechniques. 22: 1134-1139. PMID 9187764  1
1997 Horiuchi J, Silverman N, Piña B, Marcus GA, Guarente L. ADA1, a novel component of the ADA/GCN5 complex, has broader effects than GCN5, ADA2, or ADA3 Molecular and Cellular Biology. 17: 3220-3228. PMID 9154821  1
1997 Kennedy BK, Gotta M, Sinclair DA, Mills K, McNabb DS, Murthy M, Pak SM, Laroche T, Gasser SM, Guarente L. Redistribution of silencing proteins from telomeres to the nucleolus is associated with extension of life span in S. cerevisiae. Cell. 89: 381-91. PMID 9150138 DOI: 10.1016/S0092-8674(00)80219-6  1
1997 Smeal T, Guarente L. Mechanisms of cellular senescence Current Opinion in Genetics and Development. 7: 281-287. PMID 9115418 DOI: 10.1016/S0959-437X(97)80139-6  1
1997 Guarente L. What makes us tick? Science. 275: 943-944. PMID 9053999 DOI: 10.1126/science.275.5302.943  1
1996 McNabb DS, Guarente L. Genetic and biochemical probes for protein-protein interactions Current Opinion in Biotechnology. 7: 554-559. PMID 8939624 DOI: 10.1016/S0958-1669(96)80061-9  1
1996 Zhang L, Guarente L. The C6 zinc cluster dictates asymmetric binding by HAP1 Embo Journal. 15: 4676-4681. PMID 8887558  1
1996 Kennedy BK, Guarente L. Genetic analysis of aging in Saccharomyces cerevisiae Trends in Genetics. 12: 355-359. PMID 8855665 DOI: 10.1016/0168-9525(96)10039-1  1
1996 Guarente L. Do changes in chromosomes cause aging? Cell. 86: 9-12. PMID 8689691 DOI: 10.1016/S0092-8674(00)80072-0  1
1996 Marcus GA, Horiuchi J, Silverman N, Guarente L. ADA5/SPT20 links the ADA and SPT genes, which are involved in yeast transcription Molecular and Cellular Biology. 16: 3197-3205. PMID 8649430  1
1996 Knaus R, Pollock R, Guarente L. Yeast SUB1 is a suppressor of TFIIB mutations and has homology to the human co-activator PC4 Embo Journal. 15: 1933-1940. PMID 8617240  1
1996 Smeal T, Claus J, Kennedy B, Cole F, Guarente L. Loss of transcriptional silencing causes sterility in old mother cells of S. cerevisiae Cell. 84: 633-642. PMID 8598049 DOI: 10.1016/S0092-8674(00)81038-7  1
1995 Guarente L. Transcriptional coactivators in yeast and beyond Trends in Biochemical Sciences. 20: 517-521. PMID 8571454 DOI: 10.1016/S0968-0004(00)89120-3  1
1995 Horiuchi J, Silverman N, Marcus GA, Guarente L. ADA3, a putative transcriptional adaptor, consists of two separable domains and interacts with ADA2 and GCN5 in a trimeric complex Molecular and Cellular Biology. 15: 1203-1209. PMID 7862114  1
1995 Kennedy BK, Austriaco NR, Zhang J, Guarente L. Mutation in the silencing gene S/R4 can delay aging in S. cerevisiae Cell. 80: 485-496. PMID 7859289 DOI: 10.1016/0092-8674(95)90499-9  1
1995 Zhang L, Guarente L. Heme binds to a short sequence that serves a regulatory function in diverse proteins Embo Journal. 14: 313-320. PMID 7835342  1
1995 McNabb DS, Xing Y, Guarente L. Cloning of yeast HAP5: A novel subunit of a heterotrimeric complex required for CCAAT binding Genes and Development. 9: 47-58. PMID 7828851  1
1995 Haldi ML, Guarente L. Multiple domains mediate heme control of the yeast activator HAP1 Mgg Molecular & General Genetics. 248: 229-235. PMID 7651346 DOI: 10.1007/BF02190805  1
1995 Wang L, Turcotte B, Guarente L, Berger SL. The acidic transcriptional activation domains of herpes virus VP16 and yeast HAP4 have different co-factor requirements Gene. 158: 163-170. PMID 7607537 DOI: 10.1016/0378-1119(95)00126-Q  1
1994 Zhang L, Guarente L. HAP1 is nuclear but is bound to a cellular factor in the absence of heme Journal of Biological Chemistry. 269: 14643-14647. PMID 8182072  1
1994 Xing Y, Zhang S, Olesen JT, Rich A, Guarente L. Subunit interaction in the CCAAT-binding heteromeric complex is mediated by a very short α-helix in HAP2 Proceedings of the National Academy of Sciences of the United States of America. 91: 3009-3013. PMID 8159696  1
1994 Silverman N, Agapite J, Guarente L. Yeast ADA2 protein binds to the VP16 protein activation domain and activates transcription Proceedings of the National Academy of Sciences of the United States of America. 91: 11665-11668. PMID 7972120 DOI: 10.1073/pnas.91.24.11665  1
1994 Zhang L, Guarente L. The yeast activator HAP1 - A GAL4 family member-binds DNA in a directly repeated orientation Genes and Development. 8: 2110-2119. PMID 7958882  1
1994 Marcus GA, Silverman N, Berger SL, Horiuchi J, Guarente L. Functional similarity and physical association between GCN5 and ADA2: Putative transcriptional adaptors Embo Journal. 13: 4807-4815. PMID 7957049  1
1994 Kennedy BK, Austriaco NR, Guarente L. Daughter cells of Saccharomyces cerevisiae from old mothers display a reduced life span Journal of Cell Biology. 127: 1985-1993. PMID 7806576 DOI: 10.1083/jcb.127.6.1985  1
1993 Piña B, Berger S, Marcus GA, Silverman N, Agapite J, Guarente L. ADA3: a gene, identified by resistance to GAL4-VP16, with properties similar to and different from those of ADA2. Molecular and Cellular Biology. 13: 5981-9. PMID 8413201 DOI: 10.1128/mcb.13.10.5981  1
1992 Berger SL, Piña B, Silverman N, Marcus GA, Agapite J, Regier JL, Triezenberg SJ, Guarente L. Genetic isolation of ADA2: A potential transcriptional adaptor required for function of certain acidic activation domains Cell. 70: 251-265. PMID 1638630 DOI: 10.1016/0092-8674(92)90100-Q  1
1991 Schneider JC, Guarente L. Vectors for expression of cloned genes in yeast: Regulation, overproduction, and underproduction Methods in Enzymology. 194: 373-388. PMID 2005797 DOI: 10.1016/0076-6879(91)94028-B  1
1991 Schneider JC, Guarente L. Regulation of the yeast CYT1 gene encoding cytochrome c1 by HAP1 and HAP2/3/4 Molecular and Cellular Biology. 11: 4934-4942. PMID 1656218 DOI: 10.1128/MCB.11.10.4934  1
1990 Berger SL, Cress WD, Cress A, Triezenberg SJ, Guarente L. Selective inhibition of activated but not basal transcription by the acidic activation domain of VP16: evidence for transcriptional adaptors. Cell. 61: 1199-208. PMID 2163758 DOI: 10.1016/0092-8674(90)90684-7  1
1989 Buratowski S, Hahn S, Guarente L, Sharp PA. Five intermediate complexes in transcription initiation by RNA polymerase II. Cell. 56: 549-61. PMID 2917366 DOI: 10.1016/0092-8674(89)90578-3  1
1989 Forsburg SL, Guarente L. Identification and characterization of HAP4: a third component of the CCAAT-bound HAP2/HAP3 heteromer. Genes & Development. 3: 1166-78. PMID 2676721 DOI: 10.1101/gad.3.8.1166  1
1989 Elledge SJ, Sugiono P, Guarente L, Davis RW. Genetic selection for genes encoding sequence-specific DNA-binding proteins. Proceedings of the National Academy of Sciences of the United States of America. 86: 3689-93. PMID 2657725 DOI: 10.1073/pnas.86.10.3689  0.32
1989 Hahn S, Buratowski S, Sharp PA, Guarente L. Yeast TATA-binding protein TFIID binds to TATA elements with both consensus and nonconsensus DNA sequences. Proceedings of the National Academy of Sciences of the United States of America. 86: 5718-22. PMID 2569738 DOI: 10.1073/pnas.86.15.5718  1
1989 Forsburg SL, Guarente L. Communication between mitochondria and the nucleus in regulation of cytochrome genes in the yeast Saccharomyces cerevisiae. Annual Review of Cell Biology. 5: 153-80. PMID 2557058 DOI: 10.1146/annurev.cb.05.110189.001101  1
1989 Hahn S, Buratowski S, Sharp PA, Guarente L. Isolation of the gene encoding the yeast TATA binding protein TFIID: a gene identical to the SPT15 suppressor of Ty element insertions. Cell. 58: 1173-81. PMID 2550146 DOI: 10.1016/0092-8674(89)90515-1  1
1988 Buratowski S, Hahn S, Sharp PA, Guarente L. Function of a yeast TATA element-binding protein in a mammalian transcription system. Nature. 334: 37-42. PMID 3290687 DOI: 10.1038/334037a0  1
1988 Forsburg SL, Guarente L. Mutational analysis of upstream activation sequence 2 of the CYC1 gene of Saccharomyces cerevisiae: a HAP2-HAP3-responsive site. Molecular and Cellular Biology. 8: 647-54. PMID 2832731 DOI: 10.1128/MCB.8.2.647  1
1987 Schneider JC, Guarente L. The untranslated header of nuclear COX4 gene of Saccharomyces cerevisiae contains an intron Nucleic Acids Research. 15: 3515-3529. PMID 3033605 DOI: 10.1093/nar/15.8.3515  1
1986 Keng T, Alani E, Guarente L. The nine amino-terminal residues of δ-aminolevulinate synthase direct β-galactosidase into the mitochondrial matrix Molecular and Cellular Biology. 6: 355-364. PMID 3023841 DOI: 10.1128/MCB.6.2.355  1
1984 Guarente L, Lalonde B, Gifford P, Alani E. Distinctly regulated tandem upstream activation sites mediate catabolite repression of the CYC1 gene of S. cerevisiae Cell. 36: 503-511. PMID 6319028 DOI: 10.1016/0092-8674(84)90243-5  1
1983 Michaelis S, Guarente L, Beckwith J. In vitro construction and characterization of phoA-lacZ gene fusions in Escherichia coli Journal of Bacteriology. 154: 356-365. PMID 6403507  1
1982 Guarente L, Yocum RR, Gifford P. A GAL10-CYC1 hybrid yeast promoter identifies the GAL4 regulatory region as an upstream site Proceedings of the National Academy of Sciences of the United States of America. 79: 7410-7414. PMID 6760197 DOI: 10.1073/pnas.79.23.7410  1
1982 Guarente L, Nye JS, Hochschild A, Ptashne M. Mutant λ phage repressor with a specific defect in its positive control function Proceedings of the National Academy of Sciences of the United States of America. 79: 2236-2239. PMID 6212933 DOI: 10.1073/pnas.79.7.2236  1
1981 Guarente L, Ptashne M. Fusion of Escherichia coli lacZ to the cytochrome c gene of Saccharomyces cerevisiae Proceedings of the National Academy of Sciences of the United States of America. 78: 2199-2203. PMID 6264467  1
1980 Wu AM, Chapman AB, Platt T, Guarente LP, Beckwith J. Deletions of distal sequence affect termination of transcription at the end of the tryptophan operon in E. coli Cell. 19: 829-836. PMID 6991123 DOI: 10.1016/0092-8674(80)90073-2  1
1980 Guarente LP, Isberg RR, Syvanen M, Silhavy TJ. Conferral of transposable properties to a chromosomal gene in Escherichia coli. Journal of Molecular Biology. 141: 235-48. PMID 6253648 DOI: 10.1016/0022-2836(80)90179-5  1
1980 Guarente L, Lauer G, Roberts TM, Ptashne M. Improved methods for maximizing expression of a cloned gene: a bacterium that synthesizes rabbit β-globin Cell. 20: 543-553. PMID 6248249 DOI: 10.1016/0092-8674(80)90640-6  1
1980 Taniguchi T, Guarente L, Roberts TM, Kimelman D, Douhan J, Ptashne M. Expression of the human fibroblast interferon gene in Escherichia coli Proceedings of the National Academy of Sciences of the United States of America. 77: 5230-5233. PMID 6159642 DOI: 10.1073/pnas.77.9.5230  1
1980 Guarente L, Roberts TM, Ptashne M. A technique for expressing eukaryotic genes in bacteria. Science (New York, N.Y.). 209: 1428-30. PMID 6158095 DOI: 10.1126/science.6158095  1
1979 Guarente LP, Beckwth J, Wu AM, Platt T. A mutation distal to the messenger RNA endpoint reduces transcription termination in the tryptophan operon in Escherichia coli Journal of Molecular Biology. 133: 189-197. PMID 393832 DOI: 10.1016/0022-2836(79)90258-4  1
1979 Silhavy TJ, Brickman E, Bassford PJ, Casadaban MJ, Shuman HA, Schwartz V, Guarente L, Schwartz M, Beckwith JR. Structure of the malB region in Escherichia coli K12. II. Genetic map of the malE,F,G operon. Molecular & General Genetics : Mgg. 174: 249-59. PMID 384167 DOI: 10.1007/BF00267797  1
1978 Guarente LP, Beckwith J. Mutant RNA polymerase of Escherichia coli terminates transcription in strains making defective rho factor. Proceedings of the National Academy of Sciences of the United States of America. 75: 294-7. PMID 343107 DOI: 10.1073/pnas.75.1.294  1
1977 Guarente LP, Mitchell DH, Beckwith J. Transcription termination at the end of the tryptophan operon of Escherichia coli. Journal of Molecular Biology. 112: 423-36. PMID 327077 DOI: 10.1016/s0022-2836(77)80190-3  1
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