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Lars Plate, Ph.D. - Publications

Affiliations: 
2017 Chemistry Vanderbilt University, Nashville, TN 
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36 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2023 Davies JP, Sivadas A, Keller KR, Wojcikiewicz RJH, Plate L. SARS-CoV-2 Nonstructural Proteins 3 and 4 tune the Unfolded Protein Response. Biorxiv : the Preprint Server For Biology. PMID 37162862 DOI: 10.1101/2023.04.22.537917  0.405
2023 Duran-Aniotz C, Poblete N, Rivera-Krstulovic C, Ardiles ÁO, Díaz ML, Tamburini G, Mae P Sabusap C, Gerakis Y, Cabral Miranda F, Diaz J, Fuentealba M, Arriagada D, Muñoz E, Espinoza S, Martinez G, ... ... Plate L, et al. The unfolded protein response transcription factor XBP1s ameliorates Alzheimer's disease by improving synaptic function and proteostasis. Molecular Therapy : the Journal of the American Society of Gene Therapy. PMID 37016577 DOI: 10.1016/j.ymthe.2023.03.028  0.304
2021 Vidal RL, Sepulveda D, Troncoso-Escudero P, Garcia-Huerta P, Gonzalez C, Plate L, Jerez C, Canovas J, Rivera CA, Castillo V, Cisternas M, Leal S, Martinez A, Grandjean J, Lashuel HA, et al. Enforced dimerization between XBP1s and ATF6f enhances the protective effects of the unfolded protein response (UPR) in models of neurodegeneration. Molecular Therapy : the Journal of the American Society of Gene Therapy. PMID 33545358 DOI: 10.1016/j.ymthe.2021.01.033  0.731
2021 Almasy KM, Davies JP, Lisy SM, Tirgar R, Tran SC, Plate L. Small-molecule endoplasmic reticulum proteostasis regulator acts as a broad-spectrum inhibitor of dengue and Zika virus infections. Proceedings of the National Academy of Sciences of the United States of America. 118. PMID 33441483 DOI: 10.1073/pnas.2012209118  0.325
2020 Wright MT, Plate L. Revealing Functional Insights into ER Proteostasis through Proteomics and Interactomics. Experimental Cell Research. 112417. PMID 33301765 DOI: 10.1016/j.yexcr.2020.112417  0.351
2020 Kirak O, Ke E, Yang KY, Schwarz A, Plate L, Nham A, Abadejos JR, Valencia A, Wiseman RL, Lui KO, Ku M. Premature Activation of Immune Transcription Programs in Autoimmune-Predisposed Mouse Embryonic Stem Cells and Blastocysts. International Journal of Molecular Sciences. 21. PMID 32796510 DOI: 10.3390/Ijms21165743  0.527
2020 Grandjean JMD, Madhavan A, Cech L, Seguinot BO, Paxman RJ, Smith E, Scampavia L, Powers ET, Cooley CB, Plate L, Spicer TP, Kelly JW, Wiseman RL. Pharmacologic IRE1/XBP1s activation confers targeted ER proteostasis reprogramming. Nature Chemical Biology. PMID 32690944 DOI: 10.1038/S41589-020-0584-Z  0.795
2020 García-Huerta P, Troncoso-Escudero P, Wu D, Thiruvalluvan A, Cisternas-Olmedo M, Henríquez DR, Plate L, Chana-Cuevas P, Saquel C, Thielen P, Longo KA, Geddes BJ, Lederkremer GZ, Sharma N, Shenkman M, et al. Insulin-like growth factor 2 (IGF2) protects against Huntington's disease through the extracellular disposal of protein aggregates. Acta Neuropathologica. PMID 32642868 DOI: 10.1007/S00401-020-02183-1  0.619
2019 Torres SE, Gallagher CM, Plate L, Gupta M, Liem CR, Guo X, Tian R, Stroud RM, Kampmann M, Weissman JS, Walter P. Ceapins block the unfolded protein response sensor ATF6α by inducing a neomorphic inter-organelle tether. Elife. 8. PMID 31149896 DOI: 10.7554/Elife.46595  0.463
2019 Plate L, Rius B, Nguyen B, Genereux JC, Kelly JW, Wiseman RL. Quantitative Interactome Proteomics Reveals a Molecular Basis for ATF6-Dependent Regulation of a Destabilized Amyloidogenic Protein. Cell Chemical Biology. PMID 31105062 DOI: 10.1016/J.Chembiol.2019.04.001  0.796
2019 Grandjean JMD, Plate L, Morimoto RI, Bollong MJ, Powers ET, Wiseman RL. Deconvoluting Stress-Responsive Proteostasis Signaling Pathways for Pharmacologic Activation using Targeted RNA-sequencing. Acs Chemical Biology. PMID 30821953 DOI: 10.1021/Acschembio.9B00134  0.791
2019 Blackwood EA, Azizi K, Thuerauf DJ, Paxman RJ, Plate L, Kelly JW, Wiseman RL, Glembotski CC. Pharmacologic ATF6 activation confers global protection in widespread disease models by reprograming cellular proteostasis. Nature Communications. 10: 187. PMID 30643122 DOI: 10.1016/J.Yjmcc.2018.07.047  0.754
2019 Torres SE, Gallagher CM, Plate L, Gupta M, Liem CR, Guo X, Tian R, Stroud RM, Kampmann M, Weissman JS, Walter P. Author response: Ceapins block the unfolded protein response sensor ATF6α by inducing a neomorphic inter-organelle tether Elife. DOI: 10.7554/Elife.46595.022  0.339
2018 Paxman R, Plate L, Blackwood EA, Glembotski C, Powers ET, Wiseman RL, Kelly JW. Pharmacologic ATF6 activating compounds are metabolically activated to selectively modify endoplasmic reticulum proteins. Elife. 7. PMID 30084354 DOI: 10.7554/Elife.37168  0.825
2018 Kroeger H, Grimsey N, Paxman R, Chiang WC, Plate L, Jones Y, Shaw PX, Trejo J, Tsang SH, Powers E, Kelly JW, Wiseman RL, Lin JH. The unfolded protein response regulator ATF6 promotes mesodermal differentiation. Science Signaling. 11. PMID 29440509 DOI: 10.1126/Scisignal.Aan5785  0.786
2018 Paxman R, Plate L, Blackwood EA, Glembotski C, Powers ET, Wiseman RL, Kelly JW. Author response: Pharmacologic ATF6 activating compounds are metabolically activated to selectively modify endoplasmic reticulum proteins Elife. DOI: 10.7554/Elife.37168.022  0.76
2018 Blackwood EA, Azizi K, Thuerauf DJ, Paxman RJ, Plate L, Kelly JW, Wiseman RL, Glembotski CC. Abstract 547: Pharmacologic ATF6 Activation Confers Global Protection in Widespread Disease Models by Reprogramming Cellular Proteostasis Circulation Research. 123. DOI: 10.1161/Res.123.Suppl_1.547  0.73
2018 Blackwood E, Azizi K, Thuerauf D, Paxman R, Plate L, Kelly J, Wiseman R, Glembotski C. Pharmacologic ATF6 Activation Confers Global Protection in Widespread Disease Models by Reprogramming Cellular Proteostasis Journal of Molecular and Cellular Cardiology. 124: 97. DOI: 10.1016/j.yjmcc.2018.07.047  0.732
2018 Eisele YS, Janssen ME, Ma D, Nguyen B, Plate L, Morgan GJ, Reixach N, Buxbaum JN, Wiseman RL, Lander GC, Kelly JW. P3-146: Formation And Toxicity Of Transthyretin (Ttr) Oligomers In Vitro And In Patients With Familial Amyloid Polyneuropathy Alzheimers & Dementia. 14. DOI: 10.1016/J.Jalz.2018.06.1503  0.597
2017 Mortenson DE, Brighty GJ, Plate L, Bare G, Chen W, Li S, Wang H, Cravatt BF, Forli S, Powers ET, Sharpless KB, Wilson IA, Kelly JW. "Inverse Drug Discovery" Strategy To Identify Proteins That Are Targeted by Latent Electrophiles As Exemplified by Aryl Fluorosulfates. Journal of the American Chemical Society. PMID 29265822 DOI: 10.1021/Jacs.7B08366  0.766
2017 Schonhoft JD, Monteiro C, Plate L, Eisele YS, Kelly JM, Boland D, Parker CG, Cravatt BF, Teruya S, Helmke S, Maurer M, Berk J, Sekijima Y, Novais M, Coelho T, et al. Peptide probes detect misfolded transthyretin oligomers in plasma of hereditary amyloidosis patients. Science Translational Medicine. 9. PMID 28904227 DOI: 10.1126/Scitranslmed.Aam7621  0.725
2017 Chen KC, Qu S, Chowdhury S, Noxon IC, Schonhoft JD, Plate L, Powers ET, Kelly JW, Lander GC, Wiseman RL. The endoplasmic reticulum HSP40 co-chaperone ERdj3/DNAJB11 assembles and functions as a tetramer. The Embo Journal. PMID 28655754 DOI: 10.15252/Embj.201695616  0.783
2017 Plate L, Wiseman RL. Regulating Secretory Proteostasis through the Unfolded Protein Response: From Function to Therapy. Trends in Cell Biology. PMID 28647092 DOI: 10.1016/J.Tcb.2017.05.006  0.783
2017 Alvarez-Garcia O, Matsuzaki T, Olmer M, Plate L, Kelly JW, Lotz MK. REDD1 deficiency impairs autophagy and mitochondrial biogenesis in articular cartilage and increases the severity of experimental osteoarthritis. Arthritis & Rheumatology (Hoboken, N.J.). PMID 28334504 DOI: 10.1002/Art.40104  0.48
2017 Blackwood E, Plate L, Paxman R, Malter K, Wiseman L, Kelly J. High-Throughput Screen Identifies Novel Small Molecule Stress Regulator That Confers Cardioprotection During Ischemia-Reperfusion Injury Journal of Molecular and Cellular Cardiology. 112: 154. DOI: 10.1016/J.Yjmcc.2017.07.072  0.31
2016 Plate L, Cooley CB, Chen JJ, Paxman RJ, Gallagher CM, Madoux F, Genereux JC, Dobbs W, Garza D, Spicer TP, Scampavia L, Brown SJ, Rosen H, Powers ET, Walter P, et al. Small molecule proteostasis regulators that reprogram the ER to reduce extracellular protein aggregation. Elife. 5. PMID 27435961 DOI: 10.7554/Elife.15550  0.786
2016 Plate L, Paxman RJ, Wiseman RL, Kelly JW. Modulating protein quality control. Elife. 5. PMID 27435959 DOI: 10.7554/Elife.18431  0.757
2016 Chen W, Dong J, Plate L, Mortenson DE, Brighty GJ, Li S, Liu Y, Galmozzi A, Lee PS, Hulce JJ, Cravatt BF, Saez E, Powers ET, Wilson IA, Sharpless KB, et al. Arylfluorosulfates Inactivate Intracellular Lipid Binding Protein(s) through Chemoselective SuFEx Reaction with a Binding-site Tyr Residue. Journal of the American Chemical Society. PMID 27191344 DOI: 10.1021/Jacs.6B02960  0.749
2016 Plate L, Cooley CB, Chen JJ, Paxman RJ, Gallagher CM, Madoux F, Genereux JC, Dobbs W, Garza D, Spicer TP, Scampavia L, Brown SJ, Rosen H, Powers ET, Walter P, et al. Author response: Small molecule proteostasis regulators that reprogram the ER to reduce extracellular protein aggregation Elife. DOI: 10.7554/Elife.15550.026  0.774
2014 Cooley CB, Ryno LM, Plate L, Morgan GJ, Hulleman JD, Kelly JW, Wiseman RL. Unfolded protein response activation reduces secretion and extracellular aggregation of amyloidogenic immunoglobulin light chain. Proceedings of the National Academy of Sciences of the United States of America. 111: 13046-51. PMID 25157167 DOI: 10.1073/Pnas.1406050111  0.731
2013 Plate L, Marletta MA. Phosphorylation-dependent derepression by the response regulator HnoC in the Shewanella oneidensis nitric oxide signaling network. Proceedings of the National Academy of Sciences of the United States of America. 110: E4648-57. PMID 24218564 DOI: 10.1073/Pnas.1318128110  0.57
2013 Plate L, Marletta MA. Nitric oxide-sensing H-NOX proteins govern bacterial communal behavior. Trends in Biochemical Sciences. 38: 566-75. PMID 24113192 DOI: 10.1016/J.Tibs.2013.08.008  0.56
2013 Ivanisevic J, Zhu ZJ, Plate L, Tautenhahn R, Chen S, O'Brien PJ, Johnson CH, Marletta MA, Patti GJ, Siuzdak G. Toward 'omic scale metabolite profiling: a dual separation-mass spectrometry approach for coverage of lipid and central carbon metabolism. Analytical Chemistry. 85: 6876-84. PMID 23781873 DOI: 10.1021/Ac401140H  0.502
2012 Plate L, Marletta MA. Nitric oxide modulates bacterial biofilm formation through a multicomponent cyclic-di-GMP signaling network. Molecular Cell. 46: 449-60. PMID 22542454 DOI: 10.1016/J.Molcel.2012.03.023  0.56
2010 Weinert EE, Plate L, Whited CA, Olea C, Marletta MA. Determinants of ligand affinity and heme reactivity in H-NOX domains. Angewandte Chemie (International Ed. in English). 49: 720-3. PMID 20017169 DOI: 10.1002/Anie.200904799  0.719
2010 Carlson HK, Plate L, Price MS, Allen JJ, Shokat KM, Marletta MA. Use of a semisynthetic epitope to probe histidine kinase activity and regulation. Analytical Biochemistry. 397: 139-43. PMID 19819215 DOI: 10.1016/J.Ab.2009.10.009  0.752
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