Rockland Luke Wiseman, Ph.D. - Publications

Molecular and Experimental Medicine Scripps Research Institute, La Jolla, La Jolla, CA, United States 
Cellular Protein Homeostasis

53 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2019 Puchades C, Ding B, Song A, Wiseman RL, Lander GC, Glynn SE. Unique Structural Features of the Mitochondrial AAA+ Protease AFG3L2 Reveal the Molecular Basis for Activity in Health and Disease. Molecular Cell. PMID 31327635 DOI: 10.1016/J.Molcel.2019.06.016  0.36
2019 Plate L, Rius B, Nguyen B, Genereux JC, Kelly JW, Wiseman RL. Quantitative Interactome Proteomics Reveals a Molecular Basis for ATF6-Dependent Regulation of a Destabilized Amyloidogenic Protein. Cell Chemical Biology. PMID 31105062 DOI: 10.1016/J.Chembiol.2019.04.001  1
2019 Glembotski CC, Rosarda JD, Wiseman RL. Proteostasis and Beyond: ATF6 in Ischemic Disease. Trends in Molecular Medicine. PMID 31078432 DOI: 10.1016/J.Molmed.2019.03.005  0.56
2019 Grandjean JMD, Plate L, Morimoto RI, Bollong MJ, Powers ET, Wiseman RL. Deconvoluting Stress-Responsive Proteostasis Signaling Pathways for Pharmacologic Activation using Targeted RNA-sequencing. Acs Chemical Biology. PMID 30821953 DOI: 10.1021/Acschembio.9B00134  1
2019 Blackwood EA, Azizi K, Thuerauf DJ, Paxman RJ, Plate L, Kelly JW, Wiseman RL, Glembotski CC. Pharmacologic ATF6 activation confers global protection in widespread disease models by reprograming cellular proteostasis. Nature Communications. 10: 187. PMID 30643122 DOI: 10.1016/J.Yjmcc.2018.07.047  1
2018 Paxman R, Plate L, Blackwood EA, Glembotski C, Powers ET, Wiseman RL, Kelly JW. Pharmacologic ATF6 activating compounds are metabolically activated to selectively modify endoplasmic reticulum proteins. Elife. 7. PMID 30084354 DOI: 10.7554/Elife.37168  1
2018 Kroeger H, Grimsey N, Paxman R, Chiang WC, Plate L, Jones Y, Shaw PX, Trejo J, Tsang SH, Powers E, Kelly JW, Wiseman RL, Lin JH. The unfolded protein response regulator ATF6 promotes mesodermal differentiation. Science Signaling. 11. PMID 29440509 DOI: 10.1126/Scisignal.Aan5785  1
2017 Puchades C, Rampello AJ, Shin M, Giuliano CJ, Wiseman RL, Glynn SE, Lander GC. Structure of the mitochondrial inner membrane AAA+ protease YME1 gives insight into substrate processing. Science (New York, N.Y.). 358. PMID 29097521 DOI: 10.1126/Science.Aao0464  0.36
2017 Chen KC, Qu S, Chowdhury S, Noxon IC, Schonhoft JD, Plate L, Powers ET, Kelly JW, Lander GC, Wiseman RL. The endoplasmic reticulum HSP40 co-chaperone ERdj3/DNAJB11 assembles and functions as a tetramer. The Embo Journal. PMID 28655754 DOI: 10.15252/Embj.201695616  1
2017 Plate L, Wiseman RL. Regulating Secretory Proteostasis through the Unfolded Protein Response: From Function to Therapy. Trends in Cell Biology. PMID 28647092 DOI: 10.1016/J.Tcb.2017.05.006  0.8
2016 Chen JJ, Genereux JC, Suh EH, Vartabedian VF, Rius B, Qu S, Dendle MT, Kelly JW, Wiseman RL. Endoplasmic Reticulum Proteostasis Influences the Oligomeric State of an Amyloidogenic Protein Secreted from Mammalian Cells. Cell Chemical Biology. PMID 27720586 DOI: 10.1016/J.Chembiol.2016.09.001  1
2016 Plate L, Cooley CB, Chen JJ, Paxman RJ, Gallagher CM, Madoux F, Genereux JC, Dobbs W, Garza D, Spicer TP, Scampavia L, Brown SJ, Rosen H, Powers ET, Walter P, ... Wiseman RL, et al. Small molecule proteostasis regulators that reprogram the ER to reduce extracellular protein aggregation. Elife. 5. PMID 27435961 DOI: 10.7554/Elife.15550  1
2016 Plate L, Paxman RJ, Wiseman RL, Kelly JW. Modulating protein quality control. Elife. 5. PMID 27435959 DOI: 10.7554/Elife.18431  1
2015 Lindberg I, Shorter J, Wiseman RL, Chiti F, Dickey CA, McLean PJ. Chaperones in Neurodegeneration. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 35: 13853-9. PMID 26468185 DOI: 10.1523/Jneurosci.2600-15.2015  1
2015 Eisele YS, Monteiro C, Fearns C, Encalada SE, Wiseman RL, Powers ET, Kelly JW. Targeting protein aggregation for the treatment of degenerative diseases. Nature Reviews. Drug Discovery. PMID 26338154 DOI: 10.1038/Nrd4593  1
2015 Murray AN, Chen W, Antonopoulos A, Hanson SR, Wiseman RL, Dell A, Haslam SM, Powers DL, Powers ET, Kelly JW. Enhanced Aromatic Sequons Increase Oligosaccharyltransferase Glycosylation Efficiency and Glycan Homogeneity. Chemistry & Biology. 22: 1052-62. PMID 26190824 DOI: 10.1016/J.Chembiol.2015.06.017  1
2015 Baranczak A, Liu Y, Connelly S, Du WG, Greiner ER, Genereux JC, Wiseman RL, Eisele YS, Bradbury NC, Dong J, Noodleman L, Sharpless KB, Wilson IA, Encalada SE, Kelly JW. A Fluorogenic Aryl Fluorosulfate for Intraorganellar Transthyretin Imaging in Living Cells and in Caenorhabditis elegans. Journal of the American Chemical Society. 137: 7404-14. PMID 26051248 DOI: 10.1021/Jacs.5B03042  1
2015 Chen JJ, Genereux JC, Wiseman RL. Endoplasmic reticulum quality control and systemic amyloid disease: Impacting protein stability from the inside out. Iubmb Life. PMID 26018985 DOI: 10.1002/Iub.1386  1
2015 Genereux JC, Wiseman RL. Regulating extracellular proteostasis capacity through the unfolded protein response. Prion. 9: 10-21. PMID 25946012 DOI: 10.1080/19336896.2015.1011887  1
2015 Rainbolt TK, Saunders JM, Wiseman RL. YME1L degradation reduces mitochondrial proteolytic capacity during oxidative stress. Embo Reports. 16: 97-106. PMID 25433032 DOI: 10.15252/Embr.201438976  1
2015 Genereux JC, Qu S, Zhou M, Ryno LM, Wang S, Shoulders MD, Kaufman RJ, Lasmézas CI, Kelly JW, Wiseman RL. Unfolded protein response-induced ERdj3 secretion links ER stress to extracellular proteostasis. The Embo Journal. 34: 4-19. PMID 25361606 DOI: 10.15252/Embj.201488896  1
2015 Murray AN, Chen W, Antonopoulos A, Hanson SR, Wiseman RL, Dell A, Haslam SM, Powers DL, Powers ET, Kelly JW. Enhanced Aromatic Sequons Increase Oligosaccharyltransferase Glycosylation Efficiency and Glycan Homogeneity Chemistry and Biology. DOI: 10.1016/j.chembiol.2015.06.017  1
2014 Chen JJ, Genereux JC, Qu S, Hulleman JD, Shoulders MD, Wiseman RL. ATF6 activation reduces the secretion and extracellular aggregation of destabilized variants of an amyloidogenic protein. Chemistry & Biology. 21: 1564-74. PMID 25444553 DOI: 10.1016/J.Chembiol.2014.09.009  1
2014 Cooley CB, Ryno LM, Plate L, Morgan GJ, Hulleman JD, Kelly JW, Wiseman RL. Unfolded protein response activation reduces secretion and extracellular aggregation of amyloidogenic immunoglobulin light chain. Proceedings of the National Academy of Sciences of the United States of America. 111: 13046-51. PMID 25157167 DOI: 10.1073/Pnas.1406050111  1
2014 Rainbolt TK, Saunders JM, Wiseman RL. Stress-responsive regulation of mitochondria through the ER unfolded protein response. Trends in Endocrinology and Metabolism: Tem. 25: 528-37. PMID 25048297 DOI: 10.1016/J.Tem.2014.06.007  1
2014 Ryno LM, Genereux JC, Naito T, Morimoto RI, Powers ET, Shoulders MD, Wiseman RL. Characterizing the altered cellular proteome induced by the stress-independent activation of heat shock factor 1. Acs Chemical Biology. 9: 1273-83. PMID 24689980 DOI: 10.1021/Cb500062N  1
2014 Rappley I, Monteiro C, Novais M, Baranczak A, Solis G, Wiseman RL, Helmke S, Maurer MS, Coelho T, Powers ET, Kelly JW. Quantification of transthyretin kinetic stability in human plasma using subunit exchange. Biochemistry. 53: 1993-2006. PMID 24661308 DOI: 10.1021/Bi500171J  1
2013 Rainbolt TK, Atanassova N, Genereux JC, Wiseman RL. Stress-regulated translational attenuation adapts mitochondrial protein import through Tim17A degradation. Cell Metabolism. 18: 908-19. PMID 24315374 DOI: 10.1016/J.Cmet.2013.11.006  1
2013 Leung A, Nah SK, Reid W, Ebata A, Koch CM, Monti S, Genereux JC, Wiseman RL, Wolozin B, Connors LH, Berk JL, Seldin DC, Mostoslavsky G, Kotton DN, Murphy GJ. Induced pluripotent stem cell modeling of multisystemic, hereditary transthyretin amyloidosis. Stem Cell Reports. 1: 451-63. PMID 24286032 DOI: 10.1016/J.Stemcr.2013.10.003  1
2013 Shoulders MD, Ryno LM, Cooley CB, Kelly JW, Wiseman RL. Broadly applicable methodology for the rapid and dosable small molecule-mediated regulation of transcription factors in human cells. Journal of the American Chemical Society. 135: 8129-32. PMID 23682758 DOI: 10.1021/Ja402756P  1
2013 Ryno LM, Wiseman RL, Kelly JW. Targeting unfolded protein response signaling pathways to ameliorate protein misfolding diseases. Current Opinion in Chemical Biology. 17: 346-52. PMID 23647985 DOI: 10.1016/J.Cbpa.2013.04.009  1
2013 Shoulders MD, Ryno LM, Genereux JC, Moresco JJ, Tu PG, Wu C, Yates JR, Su AI, Kelly JW, Wiseman RL. Stress-independent activation of XBP1s and/or ATF6 reveals three functionally diverse ER proteostasis environments. Cell Reports. 3: 1279-92. PMID 23583182 DOI: 10.1016/J.Celrep.2013.03.024  1
2012 Bulawa CE, Connelly S, Devit M, Wang L, Weigel C, Fleming JA, Packman J, Powers ET, Wiseman RL, Foss TR, Wilson IA, Kelly JW, Labaudinière R. Tafamidis, a potent and selective transthyretin kinetic stabilizer that inhibits the amyloid cascade. Proceedings of the National Academy of Sciences of the United States of America. 109: 9629-34. PMID 22645360 DOI: 10.1073/Pnas.1121005109  1
2011 Wiseman RL, Kelly JW. Cell biology. Phosphatase inhibition delays translational recovery. Science (New York, N.Y.). 332: 44-5. PMID 21454777 DOI: 10.1126/Science.1204505  1
2011 Genereux JC, Wiseman RL. Chemically targeting the emergent properties of a chaperone complex. Chemistry & Biology. 18: 144-5. PMID 21338912 DOI: 10.1016/J.Chembiol.2011.02.002  1
2010 Wiseman RL, Zhang Y, Lee KP, Harding HP, Haynes CM, Price J, Sicheri F, Ron D. Flavonol activation defines an unanticipated ligand-binding site in the kinase-RNase domain of IRE1. Molecular Cell. 38: 291-304. PMID 20417606 DOI: 10.1016/J.Molcel.2010.04.001  1
2010 Wiseman RL, Haynes CM, Ron D. SnapShot: The unfolded protein response. Cell. 140: 590-590.e2. PMID 20178750 DOI: 10.1016/J.Cell.2010.02.006  1
2009 Wiseman RL, Kelly JW. Evolving protein stability through genetic selection. Molecular Cell. 36: 730-1. PMID 20005835 DOI: 10.1016/J.Molcel.2009.11.023  1
2009 Wiseman RL, Chin KT, Haynes CM, Stanhill A, Xu CF, Roguev A, Krogan NJ, Neubert TA, Ron D. Thioredoxin-related Protein 32 is an arsenite-regulated Thiol Reductase of the proteasome 19 S particle. The Journal of Biological Chemistry. 284: 15233-45. PMID 19349280 DOI: 10.1074/Jbc.M109.002121  1
2007 Wiseman RL, Powers ET, Buxbaum JN, Kelly JW, Balch WE. An adaptable standard for protein export from the endoplasmic reticulum. Cell. 131: 809-21. PMID 18022373 DOI: 10.1016/J.Cell.2007.10.025  1
2007 Wiseman RL, Koulov A, Powers E, Kelly JW, Balch WE. Protein energetics in maturation of the early secretory pathway. Current Opinion in Cell Biology. 19: 359-67. PMID 17686625 DOI: 10.1016/J.Ceb.2007.05.005  1
2006 Sekijima Y, Dendle MT, Wiseman RL, White JT, D'Haeze W, Kelly JW. R104H may suppress transthyretin amyloidogenesis by thermodynamic stabilization, but not by the kinetic mechanism characterizing T119 interallelic trans-suppression. Amyloid : the International Journal of Experimental and Clinical Investigation : the Official Journal of the International Society of Amyloidosis. 13: 57-66. PMID 16911959 DOI: 10.1080/13506120600722449  1
2005 Johnson SM, Wiseman RL, Sekijima Y, Green NS, Adamski-Werner SL, Kelly JW. Native state kinetic stabilization as a strategy to ameliorate protein misfolding diseases: a focus on the transthyretin amyloidoses. Accounts of Chemical Research. 38: 911-21. PMID 16359163 DOI: 10.1021/Ar020073I  1
2005 Wiseman RL, Powers ET, Kelly JW. Partitioning conformational intermediates between competing refolding and aggregation pathways: insights into transthyretin amyloid disease. Biochemistry. 44: 16612-23. PMID 16342952 DOI: 10.1021/Bi0511484  1
2005 Foss TR, Wiseman RL, Kelly JW. The pathway by which the tetrameric protein transthyretin dissociates. Biochemistry. 44: 15525-33. PMID 16300401 DOI: 10.1021/Bi051608T  1
2005 Wiseman RL, Balch WE. A new pharmacology--drugging stressed folding pathways. Trends in Molecular Medicine. 11: 347-50. PMID 16005683 DOI: 10.1016/J.Molmed.2005.06.011  1
2005 Wiseman RL, Green NS, Kelly JW. Kinetic stabilization of an oligomeric protein under physiological conditions demonstrated by a lack of subunit exchange: implications for transthyretin amyloidosis. Biochemistry. 44: 9265-74. PMID 15966751 DOI: 10.1021/Bi050352O  1
2005 Wiseman RL, Johnson SM, Kelker MS, Foss T, Wilson IA, Kelly JW. Kinetic stabilization of an oligomeric protein by a single ligand binding event. Journal of the American Chemical Society. 127: 5540-51. PMID 15826192 DOI: 10.1021/Ja042929F  1
2005 Sekijima Y, Wiseman RL, Matteson J, Hammarström P, Miller SR, Sawkar AR, Balch WE, Kelly JW. The biological and chemical basis for tissue-selective amyloid disease. Cell. 121: 73-85. PMID 15820680 DOI: 10.1016/J.Cell.2005.01.018  1
2005 Foss TR, Kelker MS, Wiseman RL, Wilson IA, Kelly JW. Kinetic stabilization of the native state by protein engineering: implications for inhibition of transthyretin amyloidogenesis. Journal of Molecular Biology. 347: 841-54. PMID 15769474 DOI: 10.1016/J.Jmb.2005.01.050  1
2003 Razavi H, Palaninathan SK, Powers ET, Wiseman RL, Purkey HE, Mohamedmohaideen NN, Deechongkit S, Chiang KP, Dendle MT, Sacchettini JC, Kelly JW. Benzoxazoles as transthyretin amyloid fibril inhibitors: synthesis, evaluation, and mechanism of action. Angewandte Chemie (International Ed. in English). 42: 2758-61. PMID 12820260 DOI: 10.1002/Anie.200351179  1
2003 Hammarström P, Sekijima Y, White JT, Wiseman RL, Lim A, Costello CE, Altland K, Garzuly F, Budka H, Kelly JW. D18G transthyretin is monomeric, aggregation prone, and not detectable in plasma and cerebrospinal fluid: a prescription for central nervous system amyloidosis? Biochemistry. 42: 6656-63. PMID 12779320 DOI: 10.1021/Bi027319B  1
2003 Hammarström P, Wiseman RL, Powers ET, Kelly JW. Prevention of transthyretin amyloid disease by changing protein misfolding energetics. Science (New York, N.Y.). 299: 713-6. PMID 12560553 DOI: 10.1126/Science.1079589  1
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