R. Luke Wiseman - Publications

Affiliations: 
2005 Scripps Research Institute, La Jolla, La Jolla, CA, United States 

136 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2024 Kline GM, Madrazo N, Cole CM, Pannikkat M, Bollong MJ, Rosarda JD, Kelly JW, Wiseman RL. Metabolically activated proteostasis regulators that protect against erastin-induced ferroptosis. Rsc Chemical Biology. 5: 866-876. PMID 39211477 DOI: 10.1039/d4cb00027g  0.478
2024 Madrazo N, Khattar Z, Powers ET, Rosarda JD, Wiseman RL. Mapping stress-responsive signaling pathways induced by mitochondrial proteostasis perturbations. Molecular Biology of the Cell. 35: ar74. PMID 38536439 DOI: 10.1091/mbc.E24-01-0041  0.579
2024 Hofmann C, Aghajani M, D Alcock C, Blackwood EA, Sandmann C, Herzog N, Groß J, Plate L, Wiseman RL, Kaufman RJ, Katus HA, Jakobi T, Völkers M, Glembotski CC, Doroudgar S. ATF6 protects against protein misfolding during cardiac hypertrophy. Journal of Molecular and Cellular Cardiology. 189: 12-24. PMID 38401179 DOI: 10.1016/j.yjmcc.2024.02.001  0.602
2024 Madrazo N, Khattar Z, Powers ET, Rosarda JD, Wiseman RL. Mapping Stress-Responsive Signaling Pathways Induced by Mitochondrial Proteostasis Perturbations. Biorxiv : the Preprint Server For Biology. PMID 38352575 DOI: 10.1101/2024.01.30.577830  0.579
2024 Touvier T, Veneri FA, Claessens A, Ferri C, Mastrangelo R, Sorgiati N, Bianchi F, Valenzano S, Del Carro U, Rivellini C, Duong P, Shy ME, Kelly JW, Svaren J, Wiseman RL, et al. Activation of XBP1s attenuates disease severity in models of proteotoxic Charcot-Marie-Tooth type 1B. Biorxiv : the Preprint Server For Biology. PMID 38352425 DOI: 10.1101/2024.01.31.577760  0.513
2023 Kline GM, Paxman RJ, Lin CY, Madrazo N, Yoon L, Grandjean JMD, Lee K, Nugroho K, Powers ET, Wiseman RL, Kelly JW. Divergent Proteome Reactivity Influences Arm-Selective Activation of the Unfolded Protein Response by Pharmacological Endoplasmic Reticulum Proteostasis Regulators. Acs Chemical Biology. PMID 37523656 DOI: 10.1021/acschembio.3c00042  0.702
2023 Perea V, Cole C, Lebeau J, Dolina V, Baron KR, Madhavan A, Kelly JW, Grotjahn DA, Wiseman RL. PERK signaling promotes mitochondrial elongation by remodeling membrane phosphatidic acid. The Embo Journal. e113908. PMID 37306086 DOI: 10.15252/embj.2023113908  0.462
2023 Kline GM, Paxman RJ, Lin CY, Madrazo N, Grandjean JM, Lee K, Nugroho K, Powers ET, Wiseman RL, Kelly JW. Divergent Proteome Reactivity Influences Arm-Selective Activation of Pharmacological Endoplasmic Reticulum Proteostasis Regulators. Biorxiv : the Preprint Server For Biology. PMID 36712115 DOI: 10.1101/2023.01.16.524237  0.686
2022 Sun S, Wang C, Zhao P, Kline GM, Grandjean JMD, Jiang X, Labaudiniere R, Wiseman RL, Kelly JW, Balch WE. Capturing the conversion of the pathogenic alpha-1-antitrypsin fold by ATF6 enhanced proteostasis. Cell Chemical Biology. PMID 36630963 DOI: 10.1016/j.chembiol.2022.12.004  0.473
2022 Mesgarzadeh JS, Romine IC, Smith-Cohen EM, Grandjean JMD, Kelly JW, Genereux JC, Wiseman RL. ATF6 Activation Reduces Amyloidogenic Transthyretin Secretion through Increased Interactions with Endoplasmic Reticulum Proteostasis Factors. Cells. 11. PMID 35626697 DOI: 10.3390/cells11101661  0.561
2022 Wang M, Cotter E, Wang YJ, Fu X, Whittsette AL, Lynch JW, Wiseman RL, Kelly JW, Keramidas A, Mu TW. Pharmacological activation of ATF6 remodels the proteostasis network to rescue pathogenic GABA receptors. Cell & Bioscience. 12: 48. PMID 35477478 DOI: 10.1186/s13578-022-00783-w  0.553
2022 Wiseman RL, Mesgarzadeh JS, Hendershot LM. Reshaping endoplasmic reticulum quality control through the unfolded protein response. Molecular Cell. 82: 1477-1491. PMID 35452616 DOI: 10.1016/j.molcel.2022.03.025  0.359
2022 Mesgarzadeh JS, Buxbaum JN, Wiseman RL. Stress-responsive regulation of extracellular proteostasis. The Journal of Cell Biology. 221. PMID 35191945 DOI: 10.1083/jcb.202112104  0.333
2022 Madhavan A, Kok BP, Rius B, Grandjean JMD, Alabi A, Albert V, Sukiasyan A, Powers ET, Galmozzi A, Saez E, Wiseman RL. Pharmacologic IRE1/XBP1s activation promotes systemic adaptive remodeling in obesity. Nature Communications. 13: 608. PMID 35105890 DOI: 10.1038/s41467-022-28271-2  0.536
2021 Rosarda JD, Baron KR, Nutsch K, Kline GM, Stanton C, Kelly JW, Bollong MJ, Wiseman RL. Metabolically Activated Proteostasis Regulators Protect against Glutamate Toxicity by Activating NRF2. Acs Chemical Biology. PMID 34797633 DOI: 10.1021/acschembio.1c00810  0.469
2021 Kroeger H, Grandjean JMD, Chiang WJ, Bindels DD, Mastey R, Okalova J, Nguyen A, Powers ET, Kelly JW, Grimsey NJ, Michaelides M, Carroll J, Wiseman RL, Lin JH. ATF6 is essential for human cone photoreceptor development. Proceedings of the National Academy of Sciences of the United States of America. 118. PMID 34561305 DOI: 10.1073/pnas.2103196118  0.64
2021 Rius B, Mesgarzadeh JS, Romine IC, Paxman RJ, Kelly JW, Wiseman RL. Pharmacologic targeting of plasma cell endoplasmic reticulum proteostasis to reduce amyloidogenic light chain secretion. Blood Advances. 5: 1037-1049. PMID 33599742 DOI: 10.1182/bloodadvances.2020002813  0.488
2021 Vidal RL, Sepulveda D, Troncoso-Escudero P, Garcia-Huerta P, Gonzalez C, Plate L, Jerez C, Canovas J, Rivera CA, Castillo V, Cisternas M, Leal S, Martinez A, Grandjean J, Lashuel HA, ... ... Wiseman RL, et al. Enforced dimerization between XBP1s and ATF6f enhances the protective effects of the unfolded protein response (UPR) in models of neurodegeneration. Molecular Therapy : the Journal of the American Society of Gene Therapy. PMID 33545358 DOI: 10.1016/j.ymthe.2021.01.033  0.739
2020 Ibrahim L, Mesgarzadeh J, Xu I, Powers ET, Wiseman RL, Bollong MJ. Defining the Functional Targets of Cap'n'collar Transcription Factors NRF1, NRF2, and NRF3. Antioxidants (Basel, Switzerland). 9. PMID 33096892 DOI: 10.3390/antiox9101025  0.556
2020 Grandjean JMD, Wiseman RL. Small molecule strategies to harness the unfolded protein response: where do we go from here? The Journal of Biological Chemistry. PMID 32887796 DOI: 10.1074/Jbc.Rev120.010218  0.452
2020 Kirak O, Ke E, Yang KY, Schwarz A, Plate L, Nham A, Abadejos JR, Valencia A, Wiseman RL, Lui KO, Ku M. Premature Activation of Immune Transcription Programs in Autoimmune-Predisposed Mouse Embryonic Stem Cells and Blastocysts. International Journal of Molecular Sciences. 21. PMID 32796510 DOI: 10.3390/Ijms21165743  0.576
2020 Giadone RM, Liberti DC, Matte TM, Rosarda JD, Torres-Arancivia C, Ghosh S, Diedrich JK, Pankow S, Skvir N, Jean JC, Yates JR, Wilson AA, Connors LH, Kotton DN, Wiseman RL, et al. Expression of Amyloidogenic Transthyretin Drives Hepatic Proteostasis Remodeling in an Induced Pluripotent Stem Cell Model of Systemic Amyloid Disease. Stem Cell Reports. PMID 32735824 DOI: 10.1016/J.Stemcr.2020.07.003  0.361
2020 Grandjean JMD, Madhavan A, Cech L, Seguinot BO, Paxman RJ, Smith E, Scampavia L, Powers ET, Cooley CB, Plate L, Spicer TP, Kelly JW, Wiseman RL. Pharmacologic IRE1/XBP1s activation confers targeted ER proteostasis reprogramming. Nature Chemical Biology. PMID 32690944 DOI: 10.1038/S41589-020-0584-Z  0.812
2020 García-Huerta P, Troncoso-Escudero P, Wu D, Thiruvalluvan A, Cisternas-Olmedo M, Henríquez DR, Plate L, Chana-Cuevas P, Saquel C, Thielen P, Longo KA, Geddes BJ, Lederkremer GZ, Sharma N, Shenkman M, ... ... Wiseman RL, et al. Insulin-like growth factor 2 (IGF2) protects against Huntington's disease through the extracellular disposal of protein aggregates. Acta Neuropathologica. PMID 32642868 DOI: 10.1007/S00401-020-02183-1  0.653
2020 Shin M, Puchades C, Asmita A, Puri N, Adjei E, Wiseman RL, Karzai AW, Lander GC. Structural basis for distinct operational modes and protease activation in AAA+ protease Lon. Science Advances. 6: eaba8404. PMID 32490208 DOI: 10.1126/Sciadv.Aba8404  0.603
2020 Romine IC, Wiseman RL. Starting at the beginning: endoplasmic reticulum proteostasis and systemic amyloid disease. The Biochemical Journal. 477: 1721-1732. PMID 32412081 DOI: 10.1042/Bcj20190312  0.673
2020 Lee EJ, Chiang WJ, Kroeger H, Bi CX, Chao DL, Skowronska-Krawczyk D, Mastey RR, Tsang SH, Chea L, Kim K, Lambert SR, Grandjean JM, Baumann B, Audo I, Kohl S, ... ... Wiseman RL, et al. Multiexon deletion alleles of ATF6 linked to achromatopsia. Jci Insight. 5. PMID 32271167 DOI: 10.1172/Jci.Insight.136041  0.606
2020 Shin M, Puchades Garcia C, Asmita A, Adjei E, Wiseman R, Karzai A, Lander GC. Open and Closed States of the AAA+ Protease Lon Provide the Structural Basis for Distinct Operational Modes Biophysical Journal. 118: 337a. DOI: 10.1016/J.Bpj.2019.11.1879  0.519
2019 Puchades C, Ding B, Song A, Wiseman RL, Lander GC, Glynn SE. Unique Structural Features of the Mitochondrial AAA+ Protease AFG3L2 Reveal the Molecular Basis for Activity in Health and Disease. Molecular Cell. PMID 31327635 DOI: 10.1016/J.Molcel.2019.06.016  0.628
2019 Carreras-Sureda A, Jaña F, Urra H, Durand S, Mortenson DE, Sagredo A, Bustos G, Hazari Y, Ramos-Fernández E, Sassano ML, Pihán P, van Vliet AR, González-Quiroz M, Torres AK, Tapia-Rojas C, ... ... Wiseman RL, et al. Publisher Correction: Non-canonical function of IRE1α determines mitochondria-associated endoplasmic reticulum composition to control calcium transfer and bioenergetics. Nature Cell Biology. PMID 31201389 DOI: 10.1038/S41556-019-0355-9  0.566
2019 Carreras-Sureda A, Jaña F, Urra H, Durand S, Mortenson DE, Sagredo A, Bustos G, Hazari Y, Ramos-Fernández E, Sassano ML, Pihán P, van Vliet AR, González-Quiroz M, Torres AK, Tapia-Rojas C, ... ... Wiseman RL, et al. Non-canonical function of IRE1α determines mitochondria-associated endoplasmic reticulum composition to control calcium transfer and bioenergetics. Nature Cell Biology. PMID 31110288 DOI: 10.1038/S41556-019-0329-Y  0.611
2019 Plate L, Rius B, Nguyen B, Genereux JC, Kelly JW, Wiseman RL. Quantitative Interactome Proteomics Reveals a Molecular Basis for ATF6-Dependent Regulation of a Destabilized Amyloidogenic Protein. Cell Chemical Biology. PMID 31105062 DOI: 10.1016/J.Chembiol.2019.04.001  0.809
2019 Glembotski CC, Rosarda JD, Wiseman RL. Proteostasis and Beyond: ATF6 in Ischemic Disease. Trends in Molecular Medicine. PMID 31078432 DOI: 10.1016/J.Molmed.2019.03.005  0.648
2019 Wiseman RL. Lining up for quality control: linear ubiquitin and proteotoxicity. The Embo Journal. PMID 30975687 DOI: 10.15252/Embj.2019101985  0.648
2019 Grandjean JMD, Plate L, Morimoto RI, Bollong MJ, Powers ET, Wiseman RL. Deconvoluting Stress-Responsive Proteostasis Signaling Pathways for Pharmacologic Activation using Targeted RNA-sequencing. Acs Chemical Biology. PMID 30821953 DOI: 10.1021/Acschembio.9B00134  0.799
2019 Romine IC, Wiseman RL. PERK Signaling Regulates Extracellular Proteostasis of an Amyloidogenic Protein During Endoplasmic Reticulum Stress. Scientific Reports. 9: 410. PMID 30675021 DOI: 10.1038/S41598-018-37207-0  0.674
2019 Blackwood EA, Azizi K, Thuerauf DJ, Paxman RJ, Plate L, Kelly JW, Wiseman RL, Glembotski CC. Pharmacologic ATF6 activation confers global protection in widespread disease models by reprograming cellular proteostasis. Nature Communications. 10: 187. PMID 30643122 DOI: 10.1016/J.Yjmcc.2018.07.047  0.767
2018 Paxman R, Plate L, Blackwood EA, Glembotski C, Powers ET, Wiseman RL, Kelly JW. Pharmacologic ATF6 activating compounds are metabolically activated to selectively modify endoplasmic reticulum proteins. Elife. 7. PMID 30084354 DOI: 10.7554/Elife.37168  0.823
2018 Lebeau J, Rainbolt TK, Wiseman RL. Coordinating Mitochondrial Biology Through the Stress-Responsive Regulation of Mitochondrial Proteases. International Review of Cell and Molecular Biology. 340: 79-128. PMID 30072094 DOI: 10.1016/Bs.Ircmb.2018.05.003  0.62
2018 Giadone RM, Rosarda JD, Akepati PR, Thomas AC, Boldbaatar B, James MF, Wilson AA, Sanchorawala V, Connors LH, Berk JL, Wiseman RL, Murphy GJ. A library of ATTR amyloidosis patient-specific induced pluripotent stem cells for disease modelling and in vitro testing of novel therapeutics. Amyloid : the International Journal of Experimental and Clinical Investigation : the Official Journal of the International Society of Amyloidosis. 1-8. PMID 30032658 DOI: 10.1080/13506129.2018.1489228  0.636
2018 Lebeau J, Saunders JM, Moraes VWR, Madhavan A, Madrazo N, Anthony MC, Wiseman RL. The PERK Arm of the Unfolded Protein Response Regulates Mitochondrial Morphology during Acute Endoplasmic Reticulum Stress. Cell Reports. 22: 2827-2836. PMID 29539413 DOI: 10.1016/J.Celrep.2018.02.055  0.645
2018 Cole KS, Grandjean JMD, Chen K, Witt CH, O'Day J, Shoulders MD, Wiseman RL, Weerapana E. Characterization of an A-Site Selective Protein Disulfide Isomerase A1 Inhibitor. Biochemistry. PMID 29521097 DOI: 10.1021/Acs.Biochem.8B00178  0.768
2018 Kroeger H, Grimsey N, Paxman R, Chiang WC, Plate L, Jones Y, Shaw PX, Trejo J, Tsang SH, Powers E, Kelly JW, Wiseman RL, Lin JH. The unfolded protein response regulator ATF6 promotes mesodermal differentiation. Science Signaling. 11. PMID 29440509 DOI: 10.1126/Scisignal.Aan5785  0.799
2018 Paxman R, Plate L, Blackwood EA, Glembotski C, Powers ET, Wiseman RL, Kelly JW. Author response: Pharmacologic ATF6 activating compounds are metabolically activated to selectively modify endoplasmic reticulum proteins Elife. DOI: 10.7554/Elife.37168.022  0.765
2018 Blackwood EA, Azizi K, Thuerauf DJ, Paxman RJ, Plate L, Kelly JW, Wiseman RL, Glembotski CC. Abstract 547: Pharmacologic ATF6 Activation Confers Global Protection in Widespread Disease Models by Reprogramming Cellular Proteostasis Circulation Research. 123. DOI: 10.1161/Res.123.Suppl_1.547  0.747
2018 Blackwood E, Azizi K, Thuerauf D, Paxman R, Plate L, Kelly J, Wiseman R, Glembotski C. Pharmacologic ATF6 Activation Confers Global Protection in Widespread Disease Models by Reprogramming Cellular Proteostasis Journal of Molecular and Cellular Cardiology. 124: 97. DOI: 10.1016/j.yjmcc.2018.07.047  0.749
2018 Eisele YS, Janssen ME, Ma D, Nguyen B, Plate L, Morgan GJ, Reixach N, Buxbaum JN, Wiseman RL, Lander GC, Kelly JW. P3-146: Formation And Toxicity Of Transthyretin (Ttr) Oligomers In Vitro And In Patients With Familial Amyloid Polyneuropathy Alzheimers & Dementia. 14. DOI: 10.1016/J.Jalz.2018.06.1503  0.646
2017 Puchades C, Rampello AJ, Shin M, Giuliano CJ, Wiseman RL, Glynn SE, Lander GC. Structure of the mitochondrial inner membrane AAA+ protease YME1 gives insight into substrate processing. Science (New York, N.Y.). 358. PMID 29097521 DOI: 10.1126/Science.Aao0464  0.58
2017 Chen KC, Qu S, Chowdhury S, Noxon IC, Schonhoft JD, Plate L, Powers ET, Kelly JW, Lander GC, Wiseman RL. The endoplasmic reticulum HSP40 co-chaperone ERdj3/DNAJB11 assembles and functions as a tetramer. The Embo Journal. PMID 28655754 DOI: 10.15252/Embj.201695616  0.802
2017 Plate L, Wiseman RL. Regulating Secretory Proteostasis through the Unfolded Protein Response: From Function to Therapy. Trends in Cell Biology. PMID 28647092 DOI: 10.1016/J.Tcb.2017.05.006  0.782
2016 Chen JJ, Genereux JC, Suh EH, Vartabedian VF, Rius B, Qu S, Dendle MT, Kelly JW, Wiseman RL. Endoplasmic Reticulum Proteostasis Influences the Oligomeric State of an Amyloidogenic Protein Secreted from Mammalian Cells. Cell Chemical Biology. PMID 27720586 DOI: 10.1016/J.Chembiol.2016.09.001  0.737
2016 Plate L, Cooley CB, Chen JJ, Paxman RJ, Gallagher CM, Madoux F, Genereux JC, Dobbs W, Garza D, Spicer TP, Scampavia L, Brown SJ, Rosen H, Powers ET, Walter P, ... Wiseman RL, et al. Small molecule proteostasis regulators that reprogram the ER to reduce extracellular protein aggregation. Elife. 5. PMID 27435961 DOI: 10.7554/Elife.15550  0.824
2016 Plate L, Paxman RJ, Wiseman RL, Kelly JW. Modulating protein quality control. Elife. 5. PMID 27435959 DOI: 10.7554/Elife.18431  0.783
2016 Rainbolt TK, Lebeau J, Puchades C, Wiseman RL. Reciprocal Degradation of YME1L and OMA1 Adapts Mitochondrial Proteolytic Activity during Stress. Cell Reports. PMID 26923599 DOI: 10.1016/J.Celrep.2016.02.011  0.608
2016 Plate L, Cooley CB, Chen JJ, Paxman RJ, Gallagher CM, Madoux F, Genereux JC, Dobbs W, Garza D, Spicer TP, Scampavia L, Brown SJ, Rosen H, Powers ET, Walter P, ... ... Wiseman RL, et al. Author response: Small molecule proteostasis regulators that reprogram the ER to reduce extracellular protein aggregation Elife. DOI: 10.7554/Elife.15550.026  0.789
2015 Lindberg I, Shorter J, Wiseman RL, Chiti F, Dickey CA, McLean PJ. Chaperones in Neurodegeneration. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 35: 13853-9. PMID 26468185 DOI: 10.1523/Jneurosci.2600-15.2015  0.661
2015 Eisele YS, Monteiro C, Fearns C, Encalada SE, Wiseman RL, Powers ET, Kelly JW. Targeting protein aggregation for the treatment of degenerative diseases. Nature Reviews. Drug Discovery. PMID 26338154 DOI: 10.1038/Nrd4593  0.79
2015 Murray AN, Chen W, Antonopoulos A, Hanson SR, Wiseman RL, Dell A, Haslam SM, Powers DL, Powers ET, Kelly JW. Enhanced Aromatic Sequons Increase Oligosaccharyltransferase Glycosylation Efficiency and Glycan Homogeneity. Chemistry & Biology. 22: 1052-62. PMID 26190824 DOI: 10.1016/J.Chembiol.2015.06.017  0.769
2015 Baranczak A, Liu Y, Connelly S, Du WG, Greiner ER, Genereux JC, Wiseman RL, Eisele YS, Bradbury NC, Dong J, Noodleman L, Sharpless KB, Wilson IA, Encalada SE, Kelly JW. A Fluorogenic Aryl Fluorosulfate for Intraorganellar Transthyretin Imaging in Living Cells and in Caenorhabditis elegans. Journal of the American Chemical Society. 137: 7404-14. PMID 26051248 DOI: 10.1021/Jacs.5B03042  0.66
2015 Chen JJ, Genereux JC, Wiseman RL. Endoplasmic reticulum quality control and systemic amyloid disease: Impacting protein stability from the inside out. Iubmb Life. PMID 26018985 DOI: 10.1002/Iub.1386  0.69
2015 Genereux JC, Wiseman RL. Regulating extracellular proteostasis capacity through the unfolded protein response. Prion. 9: 10-21. PMID 25946012 DOI: 10.1080/19336896.2015.1011887  0.708
2015 Rainbolt TK, Saunders JM, Wiseman RL. YME1L degradation reduces mitochondrial proteolytic capacity during oxidative stress. Embo Reports. 16: 97-106. PMID 25433032 DOI: 10.15252/Embr.201438976  0.613
2015 Genereux JC, Qu S, Zhou M, Ryno LM, Wang S, Shoulders MD, Kaufman RJ, Lasmézas CI, Kelly JW, Wiseman RL. Unfolded protein response-induced ERdj3 secretion links ER stress to extracellular proteostasis. The Embo Journal. 34: 4-19. PMID 25361606 DOI: 10.15252/Embj.201488896  0.825
2015 Murray AN, Chen W, Antonopoulos A, Hanson SR, Wiseman RL, Dell A, Haslam SM, Powers DL, Powers ET, Kelly JW. Enhanced Aromatic Sequons Increase Oligosaccharyltransferase Glycosylation Efficiency and Glycan Homogeneity Chemistry and Biology. DOI: 10.1016/j.chembiol.2015.06.017  0.756
2014 Chen JJ, Genereux JC, Qu S, Hulleman JD, Shoulders MD, Wiseman RL. ATF6 activation reduces the secretion and extracellular aggregation of destabilized variants of an amyloidogenic protein. Chemistry & Biology. 21: 1564-74. PMID 25444553 DOI: 10.1016/J.Chembiol.2014.09.009  0.824
2014 Cooley CB, Ryno LM, Plate L, Morgan GJ, Hulleman JD, Kelly JW, Wiseman RL. Unfolded protein response activation reduces secretion and extracellular aggregation of amyloidogenic immunoglobulin light chain. Proceedings of the National Academy of Sciences of the United States of America. 111: 13046-51. PMID 25157167 DOI: 10.1073/Pnas.1406050111  0.794
2014 Rainbolt TK, Saunders JM, Wiseman RL. Stress-responsive regulation of mitochondria through the ER unfolded protein response. Trends in Endocrinology and Metabolism: Tem. 25: 528-37. PMID 25048297 DOI: 10.1016/J.Tem.2014.06.007  0.663
2014 Ryno LM, Genereux JC, Naito T, Morimoto RI, Powers ET, Shoulders MD, Wiseman RL. Characterizing the altered cellular proteome induced by the stress-independent activation of heat shock factor 1. Acs Chemical Biology. 9: 1273-83. PMID 24689980 DOI: 10.1021/Cb500062N  0.803
2014 Rappley I, Monteiro C, Novais M, Baranczak A, Solis G, Wiseman RL, Helmke S, Maurer MS, Coelho T, Powers ET, Kelly JW. Quantification of transthyretin kinetic stability in human plasma using subunit exchange. Biochemistry. 53: 1993-2006. PMID 24661308 DOI: 10.1021/Bi500171J  0.745
2013 Rainbolt TK, Atanassova N, Genereux JC, Wiseman RL. Stress-regulated translational attenuation adapts mitochondrial protein import through Tim17A degradation. Cell Metabolism. 18: 908-19. PMID 24315374 DOI: 10.1016/J.Cmet.2013.11.006  0.654
2013 Leung A, Nah SK, Reid W, Ebata A, Koch CM, Monti S, Genereux JC, Wiseman RL, Wolozin B, Connors LH, Berk JL, Seldin DC, Mostoslavsky G, Kotton DN, Murphy GJ. Induced pluripotent stem cell modeling of multisystemic, hereditary transthyretin amyloidosis. Stem Cell Reports. 1: 451-63. PMID 24286032 DOI: 10.1016/J.Stemcr.2013.10.003  0.639
2013 Shoulders MD, Ryno LM, Cooley CB, Kelly JW, Wiseman RL. Broadly applicable methodology for the rapid and dosable small molecule-mediated regulation of transcription factors in human cells. Journal of the American Chemical Society. 135: 8129-32. PMID 23682758 DOI: 10.1021/Ja402756P  0.77
2013 Ryno LM, Wiseman RL, Kelly JW. Targeting unfolded protein response signaling pathways to ameliorate protein misfolding diseases. Current Opinion in Chemical Biology. 17: 346-52. PMID 23647985 DOI: 10.1016/J.Cbpa.2013.04.009  0.827
2013 Shoulders MD, Ryno LM, Genereux JC, Moresco JJ, Tu PG, Wu C, Yates JR, Su AI, Kelly JW, Wiseman RL. Stress-independent activation of XBP1s and/or ATF6 reveals three functionally diverse ER proteostasis environments. Cell Reports. 3: 1279-92. PMID 23583182 DOI: 10.1016/J.Celrep.2013.03.024  0.812
2013 Wiseman RL, Kelly PT, Swanney MP, McNamara KP, Beckert L. Hypoxemia in healthy subjects at moderate altitude. Aviation, Space, and Environmental Medicine. 84: 22-6. PMID 23304995 DOI: 10.3357/ASEM.3366.2013  0.489
2012 Bulawa CE, Connelly S, Devit M, Wang L, Weigel C, Fleming JA, Packman J, Powers ET, Wiseman RL, Foss TR, Wilson IA, Kelly JW, Labaudinière R. Tafamidis, a potent and selective transthyretin kinetic stabilizer that inhibits the amyloid cascade. Proceedings of the National Academy of Sciences of the United States of America. 109: 9629-34. PMID 22645360 DOI: 10.1073/Pnas.1121005109  0.758
2011 Tressler CS, Wiseman RL, Dombi TM, Jessen B, Huang K, Kwok KK, Wirostko BM. Lack of evidence for a link between latanoprost use and malignant melanoma: an analysis of safety databases and a review of the literature. The British Journal of Ophthalmology. 95: 1490-5. PMID 21515566 DOI: 10.1136/bjo.2010.193987  0.52
2011 Wiseman RL, Kelly JW. Cell biology. Phosphatase inhibition delays translational recovery. Science (New York, N.Y.). 332: 44-5. PMID 21454777 DOI: 10.1126/Science.1204505  0.731
2011 Genereux JC, Wiseman RL. Chemically targeting the emergent properties of a chaperone complex. Chemistry & Biology. 18: 144-5. PMID 21338912 DOI: 10.1016/J.Chembiol.2011.02.002  0.606
2010 Wiseman RL, Zhang Y, Lee KP, Harding HP, Haynes CM, Price J, Sicheri F, Ron D. Flavonol activation defines an unanticipated ligand-binding site in the kinase-RNase domain of IRE1. Molecular Cell. 38: 291-304. PMID 20417606 DOI: 10.1016/J.Molcel.2010.04.001  0.722
2010 Wiseman RL, Haynes CM, Ron D. SnapShot: The unfolded protein response. Cell. 140: 590-590.e2. PMID 20178750 DOI: 10.1016/J.Cell.2010.02.006  0.643
2009 Wiseman RL, Kelly JW. Evolving protein stability through genetic selection. Molecular Cell. 36: 730-1. PMID 20005835 DOI: 10.1016/J.Molcel.2009.11.023  0.696
2009 Wiseman RL, Chin KT, Haynes CM, Stanhill A, Xu CF, Roguev A, Krogan NJ, Neubert TA, Ron D. Thioredoxin-related Protein 32 is an arsenite-regulated Thiol Reductase of the proteasome 19 S particle. The Journal of Biological Chemistry. 284: 15233-45. PMID 19349280 DOI: 10.1074/Jbc.M109.002121  0.633
2007 Wiseman RL, Powers ET, Buxbaum JN, Kelly JW, Balch WE. An adaptable standard for protein export from the endoplasmic reticulum. Cell. 131: 809-21. PMID 18022373 DOI: 10.1016/J.Cell.2007.10.025  0.788
2007 Wiseman RL, Koulov A, Powers E, Kelly JW, Balch WE. Protein energetics in maturation of the early secretory pathway. Current Opinion in Cell Biology. 19: 359-67. PMID 17686625 DOI: 10.1016/J.Ceb.2007.05.005  0.782
2006 Sekijima Y, Dendle MT, Wiseman RL, White JT, D'Haeze W, Kelly JW. R104H may suppress transthyretin amyloidogenesis by thermodynamic stabilization, but not by the kinetic mechanism characterizing T119 interallelic trans-suppression. Amyloid : the International Journal of Experimental and Clinical Investigation : the Official Journal of the International Society of Amyloidosis. 13: 57-66. PMID 16911959 DOI: 10.1080/13506120600722449  0.802
2005 Johnson SM, Wiseman RL, Sekijima Y, Green NS, Adamski-Werner SL, Kelly JW. Native state kinetic stabilization as a strategy to ameliorate protein misfolding diseases: a focus on the transthyretin amyloidoses. Accounts of Chemical Research. 38: 911-21. PMID 16359163 DOI: 10.1021/Ar020073I  0.801
2005 Wiseman RL, Powers ET, Kelly JW. Partitioning conformational intermediates between competing refolding and aggregation pathways: insights into transthyretin amyloid disease. Biochemistry. 44: 16612-23. PMID 16342952 DOI: 10.1021/Bi0511484  0.784
2005 Foss TR, Wiseman RL, Kelly JW. The pathway by which the tetrameric protein transthyretin dissociates. Biochemistry. 44: 15525-33. PMID 16300401 DOI: 10.1021/Bi051608T  0.685
2005 Wiseman RL, Balch WE. A new pharmacology--drugging stressed folding pathways. Trends in Molecular Medicine. 11: 347-50. PMID 16005683 DOI: 10.1016/J.Molmed.2005.06.011  0.686
2005 Wiseman RL, Green NS, Kelly JW. Kinetic stabilization of an oligomeric protein under physiological conditions demonstrated by a lack of subunit exchange: implications for transthyretin amyloidosis. Biochemistry. 44: 9265-74. PMID 15966751 DOI: 10.1021/Bi050352O  0.749
2005 Wiseman RL, Johnson SM, Kelker MS, Foss T, Wilson IA, Kelly JW. Kinetic stabilization of an oligomeric protein by a single ligand binding event. Journal of the American Chemical Society. 127: 5540-51. PMID 15826192 DOI: 10.1021/Ja042929F  0.728
2005 Sekijima Y, Wiseman RL, Matteson J, Hammarström P, Miller SR, Sawkar AR, Balch WE, Kelly JW. The biological and chemical basis for tissue-selective amyloid disease. Cell. 121: 73-85. PMID 15820680 DOI: 10.1016/J.Cell.2005.01.018  0.805
2005 Foss TR, Kelker MS, Wiseman RL, Wilson IA, Kelly JW. Kinetic stabilization of the native state by protein engineering: implications for inhibition of transthyretin amyloidogenesis. Journal of Molecular Biology. 347: 841-54. PMID 15769474 DOI: 10.1016/J.Jmb.2005.01.050  0.678
2003 Razavi H, Palaninathan SK, Powers ET, Wiseman RL, Purkey HE, Mohamedmohaideen NN, Deechongkit S, Chiang KP, Dendle MT, Sacchettini JC, Kelly JW. Benzoxazoles as transthyretin amyloid fibril inhibitors: synthesis, evaluation, and mechanism of action. Angewandte Chemie (International Ed. in English). 42: 2758-61. PMID 12820260 DOI: 10.1002/Anie.200351179  0.763
2003 Hammarström P, Sekijima Y, White JT, Wiseman RL, Lim A, Costello CE, Altland K, Garzuly F, Budka H, Kelly JW. D18G transthyretin is monomeric, aggregation prone, and not detectable in plasma and cerebrospinal fluid: a prescription for central nervous system amyloidosis? Biochemistry. 42: 6656-63. PMID 12779320 DOI: 10.1021/Bi027319B  0.777
2003 Hammarström P, Wiseman RL, Powers ET, Kelly JW. Prevention of transthyretin amyloid disease by changing protein misfolding energetics. Science (New York, N.Y.). 299: 713-6. PMID 12560553 DOI: 10.1126/Science.1079589  0.801
2000 Luo SH, Wiseman RL. Ethnic language maintenance among chinese immigrant children in the United States * International Journal of Intercultural Relations. 24: 307-324.  0.497
1998 Nishida H, Hammer MR, Wiseman RL. Cognitive differences between Japanese and Americans in their perceptions of difficult social situations Journal of Cross-Cultural Psychology. 29: 499-524.  0.489
1997 Lépine J, Wiseman R, Zhu G. A double-blind efficacy and safety study of sertraline and clomipramine in severe major depression Biological Psychiatry. 42: 249S. DOI: 10.1016/S0006-3223(97)87943-7  0.499
1996 Lépine J, Wiseman R. Treatment of severe major depression: A double-blind study of sertraline and clomipramine European Neuropsychopharmacology. 6: 123-124. DOI: 10.1016/0924-977X(96)87872-2  0.5
1996 Hammer MR, Nishida H, Wiseman RL. The influence of situational prototypes on dimensions of intercultural communication competence Journal of Cross-Cultural Psychology. 27: 267-282.  0.504
1995 Guelfi J, Wiseman R. P-2-45 The treatment of dysthymia with sertraline: A double-blind placebo-controlled trial in dysthymic outpatients without major depression European Neuropsychopharmacology. 5: 289-290. DOI: 10.1016/0924-977X(95)90410-F  0.5
1994 Sanders JA, Wiseman RL, Gass RH. Does Teaching Argumentation Facilitate Critical Thinking? Communication Reports. 7: 27-35. DOI: 10.1080/08934219409367580  0.486
1992 Sueda K, Wiseman RL. Embarrassment remediation in Japan and the United States International Journal of Intercultural Relations. 16: 159-173. DOI: 10.1016/0147-1767(92)90016-N  0.5
1991 Sueda K, Wiseman RL. Readjustment problems of japanese sojoumers' children Howard Journal of Communications. 3: 73-86. DOI: 10.1080/10646179109359738  0.49
1991 Gudykunst WB, Ting-Toomey S, Wiseman RL. Taming the beast: Designing a course in intercultural communication Communication Education. 40: 272-285. DOI: 10.1080/03634529109378851  0.496
1990 Sanders JA, Wiseman RL, Matz SI. The influence of gender on reported disclosure, interrogation, and nonverbal immediacy in same-sex dyads: An empirical study of uncertainty reduction theory Women's Studies in Communication. 13: 85-108. DOI: 10.1080/07491409.1990.11089747  0.498
1990 Sanders JA, Wiseman RL. The effects of verbal and nonverbal teacher immediacy on perceived cognitive, affective, and behavioral learning in the multicultural classroom Communication Education. 39: 341-353. DOI: 10.1080/03634529009378814  0.489
1990 Meaders MA, Wiseman RL. A randomized multicenter comparison of piroxicam and diclofenac in the treatment of acute musculoskeletal injuries Current Therapeutic Research - Clinical and Experimental. 47: 971-981.  0.495
1989 Kroll MP, Wiseman RL, Guttadauria M. A clinical evaluation of piroxicam gel: an open comparative trial with diclofenac gel in the treatment of acute musculoskeletal disorders. Clinical Therapeutics. 11: 382-91. PMID 2663165  0.507
1989 Wiseman RL, Hammer MR, Nishida H. Predictors of intercultural communication competence International Journal of Intercultural Relations. 13: 349-370. DOI: 10.1016/0147-1767(89)90017-5  0.513
1988 Wiseman RL, Emry RA, Morgan D. Predicting academic success for disabled students in higher education Research in Higher Education. 28: 255-269. DOI: 10.1007/BF00992234  0.487
1987 Emry R, Wiseman RL. An intercultural understanding of ablebodied and disabled persons' communication International Journal of Intercultural Relations. 11: 7-27. DOI: 10.1016/0147-1767(87)90029-0  0.499
1987 Wiseman RL, Sodergren J, Guttadauria M, Ryan AJ. Treatment of acute musculoskeletal disorders with piroxicam: Results of a double-blind multicenter comparison with naproxen Current Therapeutic Research - Clinical and Experimental. 42: 974-987.  0.506
1987 Wiseman RL, Sodergren J, Guttadauria M, Ryan AJ. Treatment of acute musculoskeletal disorders with piroxicam: Results of a double-blind multicenter comparison with indomethacin Current Therapeutic Research - Clinical and Experimental. 42: 517-529.  0.505
1985 Wiseman RL, Kilgour M. Intramuscular piroxicam, a new dosage form, in the treatment of acute musculoskeletal disorders. The Journal of International Medical Research. 13: 255-62. PMID 2932357 DOI: 10.1177/030006058501300502  0.51
1984 Wiseman RL, Abe H. Finding and explaining differences. A reply to Gudykunst and Hammer International Journal of Intercultural Relations. 8: 11-16. DOI: 10.1016/0147-1767(84)90004-X  0.511
1983 Abe H, Wiseman RL. A cross-cultural confirmation of the dimensions of intercultural effectiveness International Journal of Intercultural Relations. 7: 53-67. DOI: 10.1016/0147-1767(83)90005-6  0.504
1982 Schenck-Hamlin WJ, Georgacarakos GN, Wiseman RL. A formal account of interpersonal compliance-gaining Communication Quarterly. 30: 173-180. DOI: 10.1080/01463378209369446  0.499
1981 Nakashima Y, Frangione B, Wiseman RL, Konigsberg WH. Primary structure of the major coat protein of the filamentous bacterial viruses, If1 and Ike. The Journal of Biological Chemistry. 256: 5792-7. PMID 7240173  0.561
1981 Wiseman RL, Schenck-Hamlin W. A Multidimensional Scaling Validation of an Inductively-Derived Set of Compliance-Gaining Strategies Communication Monographs. 48: 251-270. DOI: 10.1080/03637758109376062  0.507
1980 Chen FC, Koopmans G, Wiseman RL, Day LA, Swinney HL. Dimensions of Xf virus from its rotational and translational diffusion coefficients. Biochemistry. 19: 1373-6. PMID 7387996  0.5
1979 Day LA, Wiseman RL, Marzec CJ. Structure models for DNA in filamentous viruses with phosphates near the center. Nucleic Acids Research. 7: 1393-403. PMID 503855  0.526
1978 Frangione B, Nakashima Y, Konigsberg W, Wiseman RL. The amino acid sequence of the major coat protein subunit of the filamentous virus Xf. Febs Letters. 96: 381-4. PMID 729805 DOI: 10.1016/0014-5793(78)80442-6  0.533
1978 Hammer MR, Gudykunst WB, Wiseman RL. Dimensions of intercultural effectiveness: An exploratory study International Journal of Intercultural Relations. 2: 382-393. DOI: 10.1016/0147-1767(78)90036-6  0.511
1977 Wiseman RL, Day LA. Different packaging of DNA in the filamentous viruses Pf1 and Xf. Journal of Molecular Biology. 116: 607-11. PMID 592394 DOI: 10.1016/0022-2836(77)90088-2  0.497
1977 Gudykunst WB, Hammer MR, Wiseman RL. An analysis of an integrated approach to cross-cultural training International Journal of Intercultural Relations. 1: 99-110. DOI: 10.1016/0147-1767(77)90045-1  0.499
1976 Wiseman RL, Berkowitz SA, Day LA. Different arrangements of protein subunits and single-stranded circular DNA in the filamentous bacterial viruses fd and Pf1. Journal of Molecular Biology. 102: 549-61. PMID 775111 DOI: 10.1016/0022-2836(76)90333-8  0.548
1975 Nakashima Y, Wiseman RL, Konigsberg W, Marvin DA. Primary structure and sidechain interactions of PFL filamentous bacterial virus coat protein. Nature. 253: 68-71. PMID 1110754 DOI: 10.1038/253068A0  0.564
1974 Dunker AK, Klausner RD, Marvin DA, Wiseman RL. Letter: Filamentous bacterial viruses. X. X-ray diffraction studies of the R4-protein mutant. Journal of Molecular Biology. 82: 115-7. PMID 4818480 DOI: 10.1016/0022-2836(74)90579-8  0.526
1974 Wachtel EJ, Wiseman RL, Pigram WJ, Marvin DA. Filamentous bacterial viruses. XIII. Molecular structure of the virion in projection. Journal of Molecular Biology. 88: 601-18. PMID 4449123 DOI: 10.1016/0022-2836(74)90411-2  0.516
1974 Marvin DA, Pigram WJ, Wiseman RL, Wachtel EJ, Marvin FJ. Filamentous bacterial viruses. XIL. Molecular architecture of the class I (fd, If1, IKe) virion. Journal of Molecular Biology. 88: 581-98. PMID 4449121 DOI: 10.1016/0022-2836(74)90409-4  0.522
1974 Marvin DA, Wiseman RL, Wachtel EJ. Filamentous bacterial viruses. XI. Molecular architecture of the class II (Pf1, Xf) virion. Journal of Molecular Biology. 82: 121-38. PMID 4206038 DOI: 10.1016/0022-2836(74)90336-2  0.513
1972 Wiseman RL, Fothergill JE, Fothergill LA. Replacement of asparagine by aspartic acid in hen ovalbumin and a difference in immunochemical reactivity. The Biochemical Journal. 127: 775-80. PMID 5076226  0.518
1972 Wiseman RL, Dunker AK, Marvin DA. Filamentous bacterial viruses. 3. Physical and chemical characterization of the If1 virion. Virology. 48: 230-44. PMID 4552788 DOI: 10.1016/0042-6822(72)90130-4  0.51
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