Dafna Bar-Sagi - Publications

Basic Medical Science New York University, New York, NY, United States 
Oncology, Molecular Biology, Biochemistry

153 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2020 Yoo DY, Barros SA, Brown GC, Rabot C, Bar-Sagi D, Arora PS. Macropinocytosis as a Key Determinant of Peptidomimetic Uptake in Cancer Cells. Journal of the American Chemical Society. PMID 32786217 DOI: 10.1021/jacs.0c02109  0.32
2020 Yoo DY, Hauser AD, Joy ST, Bar-Sagi D, Arora PS. Covalent Targeting of Ras G12C by Rationally Designed Peptidomimetics. Acs Chemical Biology. PMID 32378881 DOI: 10.1021/acschembio.0c00204  0.32
2016 Grabocka E, Bar-Sagi D. Mutant KRAS Enhances Tumor Cell Fitness by Upregulating Stress Granules. Cell. 167: 1803-1813.e12. PMID 27984728 DOI: 10.1016/j.cell.2016.11.035  0.48
2016 Christensen SM, Tu HL, Jun JE, Alvarez S, Triplet MG, Iwig JS, Yadav KK, Bar-Sagi D, Roose JP, Groves JT. One-way membrane trafficking of SOS in receptor-triggered Ras activation. Nature Structural & Molecular Biology. PMID 27501536 DOI: 10.1038/nsmb.3275  0.8
2016 Sundstrom A, Grabocka E, Bar-Sagi D, Mishra B. Histological Image Processing Features Induce a Quantitative Characterization of Chronic Tumor Hypoxia. Plos One. 11: e0153623. PMID 27093539 DOI: 10.1371/journal.pone.0153623  1
2016 Pylayeva-Gupta Y, Das S, Handler JS, Hajdu CH, Coffre M, Koralov SB, Bar-Sagi D. IL35-producing b cells promote the development of pancreatic neoplasia Cancer Discovery. 6: 247-255.  1
2015 Pylayeva-Gupta Y, Das S, Handler JS, Hajdu CH, Coffre M, Koralov S, Bar-Sagi D. IL-35 producing B cells promote the development of pancreatic neoplasia. Cancer Discovery. PMID 26715643 DOI: 10.1158/2159-8290.CD-15-0843  0.48
2015 Kamphorst JJ, Nofal M, Commisso C, Hackett SR, Lu W, Grabocka E, Vander Heiden MG, Miller G, Drebin JA, Bar-Sagi D, Thompson CB, Rabinowitz JD. Human pancreatic cancer tumors are nutrient poor and tumor cells actively scavenge extracellular protein. Cancer Research. 75: 544-53. PMID 25644265 DOI: 10.1158/0008-5472.CAN-14-2211  0.48
2015 Grabocka E, Commisso C, Bar-Sagi D. Molecular pathways: targeting the dependence of mutant RAS cancers on the DNA damage response. Clinical Cancer Research : An Official Journal of the American Association For Cancer Research. 21: 1243-7. PMID 25424849 DOI: 10.1158/1078-0432.CCR-14-0650  1
2015 Fennell M, Commisso C, Ramirez C, Garippa R, Bar-Sagi D. High-Content, Full Genome siRNA Screen for Regulators of Oncogenic HRAS-Driven Macropinocytosis Assay and Drug Development Technologies. 13: 347-355. DOI: 10.1089/adt.2015.660  1
2014 Lubkov V, Bar-Sagi D. E-cadherin-mediated cell coupling is required for apoptotic cell extrusion. Current Biology : Cb. 24: 868-74. PMID 24704076 DOI: 10.1016/j.cub.2014.02.057  1
2014 Grabocka E, Pylayeva-Gupta Y, Jones MJ, Lubkov V, Yemanaberhan E, Taylor L, Jeng HH, Bar-Sagi D. Wild-type H- and N-Ras promote mutant K-Ras-driven tumorigenesis by modulating the DNA damage response. Cancer Cell. 25: 243-56. PMID 24525237 DOI: 10.1016/j.ccr.2014.01.005  1
2014 Commisso C, Flinn RJ, Bar-Sagi D. Determining the macropinocytic index of cells through a quantitative image-based assay. Nature Protocols. 9: 182-92. PMID 24385148 DOI: 10.1038/nprot.2014.004  1
2014 Court H, Philips MR, Bar-Sagi D. The biology of K-Ras signaling pathways in pancreatic cancer Molecular Genetics of Pancreatic Cancer. 83-115. DOI: 10.1007/978-1-4614-6549-2_5  1
2013 Nickerson S, Joy ST, Arora PS, Bar-Sagi D. An orthosteric inhibitor of the RAS-SOS interaction. The Enzymes. 34: 25-39. PMID 25034099 DOI: 10.1016/B978-0-12-420146-0.00002-0  1
2013 Court H, Amoyel M, Hackman M, Lee KE, Xu R, Miller G, Bar-Sagi D, Bach EA, Bergö MO, Philips MR. Isoprenylcysteine carboxylmethyltransferase deficiency exacerbates KRAS-driven pancreatic neoplasia via Notch suppression. The Journal of Clinical Investigation. 123: 4681-94. PMID 24216479 DOI: 10.1172/JCI65764  1
2013 Dultz LA, Dhar S, Ogilvie JB, Heller KS, Bar-Sagi D, Patel KN. Clinical and therapeutic implications of Sprouty2 feedback dysregulation in BRAF V600E-mutation-positive papillary thyroid cancer. Surgery. 154: 1239-44; discussion . PMID 24094449 DOI: 10.1016/j.surg.2013.06.024  1
2013 Commisso C, Davidson SM, Soydaner-Azeloglu RG, Parker SJ, Kamphorst JJ, Hackett S, Grabocka E, Nofal M, Drebin JA, Thompson CB, Rabinowitz JD, Metallo CM, Vander Heiden MG, Bar-Sagi D. Macropinocytosis of protein is an amino acid supply route in Ras-transformed cells. Nature. 497: 633-7. PMID 23665962 DOI: 10.1038/nature12138  1
2013 Pylayeva-Gupta Y, Lee KE, Bar-Sagi D. Microdissection and culture of murine pancreatic ductal epithelial cells. Methods in Molecular Biology (Clifton, N.J.). 980: 267-79. PMID 23359159 DOI: 10.1007/978-1-62703-287-2_14  1
2012 Jeng HH, Taylor LJ, Bar-Sagi D. Sos-mediated cross-activation of wild-type Ras by oncogenic Ras is essential for tumorigenesis Nature Communications. 3. PMID 23132018 DOI: 10.1038/ncomms2173  1
2012 Ochi A, Nguyen AH, Bedrosian AS, Mushlin HM, Zarbakhsh S, Barilla R, Zambirinis CP, Fallon NC, Rehman A, Pylayeva-Gupta Y, Badar S, Hajdu CH, Frey AB, Bar-Sagi D, Miller G. MyD88 inhibition amplifies dendritic cell capacity to promote pancreatic carcinogenesis via Th2 cells. The Journal of Experimental Medicine. 209: 1671-87. PMID 22908323 DOI: 10.1084/jem.20111706  1
2012 Zheng ZY, Xu L, Bar-Sagi D, Chang EC. Escorting Ras. Small Gtpases. 3: 236-9. PMID 22735486 DOI: 10.4161/sgtp.20460  1
2012 Yang MH, Nickerson S, Kim ET, Liot C, Laurent G, Spang R, Philips MR, Shan Y, Shaw DE, Bar-Sagi D, Haigis MC, Haigis KM. Regulation of RAS oncogenicity by acetylation. Proceedings of the National Academy of Sciences of the United States of America. 109: 10843-8. PMID 22711838 DOI: 10.1073/pnas.1201487109  1
2012 Pylayeva-Gupta Y, Lee KE, Hajdu CH, Miller G, Bar-Sagi D. Oncogenic Kras-induced GM-CSF production promotes the development of pancreatic neoplasia. Cancer Cell. 21: 836-47. PMID 22698407 DOI: 10.1016/j.ccr.2012.04.024  1
2012 Cao Y, E G, Wang E, Pal K, Dutta SK, Bar-Sagi D, Mukhopadhyay D. VEGF exerts an angiogenesis-independent function in cancer cells to promote their malignant progression. Cancer Research. 72: 3912-8. PMID 22693250 DOI: 10.1158/0008-5472.CAN-11-4058  1
2012 Mallen-St Clair J, Soydaner-Azeloglu R, Lee KE, Taylor L, Livanos A, Pylayeva-Gupta Y, Miller G, Margueron R, Reinberg D, Bar-Sagi D. EZH2 couples pancreatic regeneration to neoplastic progression. Genes & Development. 26: 439-44. PMID 22391448 DOI: 10.1101/gad.181800.111  1
2012 Zheng ZY, Cheng CM, Fu XR, Chen LY, Xu L, Terrillon S, Wong ST, Bar-Sagi D, Songyang Z, Chang EC. CHMP6 and VPS4A mediate the recycling of Ras to the plasma membrane to promote growth factor signaling. Oncogene. 31: 4630-8. PMID 22231449 DOI: 10.1038/onc.2011.607  1
2012 Ahearn IM, Haigis K, Bar-Sagi D, Philips MR. Regulating the regulator: post-translational modification of RAS. Nature Reviews. Molecular Cell Biology. 13: 39-51. PMID 22189424 DOI: 10.1038/nrm3255  1
2011 Pylayeva-Gupta Y, Grabocka E, Bar-Sagi D. RAS oncogenes: weaving a tumorigenic web. Nature Reviews. Cancer. 11: 761-74. PMID 21993244 DOI: 10.1038/nrc3106  1
2011 Patgiri A, Yadav KK, Arora PS, Bar-Sagi D. An orthosteric inhibitor of the Ras-Sos interaction. Nature Chemical Biology. 7: 585-7. PMID 21765406 DOI: 10.1038/nchembio.612  1
2011 Lin F, Ren XD, Pan Z, Macri L, Zong WX, Tonnesen MG, Rafailovich M, Bar-Sagi D, Clark RA. Fibronectin growth factor-binding domains are required for fibroblast survival. The Journal of Investigative Dermatology. 131: 84-98. PMID 20811396 DOI: 10.1038/jid.2010.253  1
2010 Nimnual AS, Taylor LJ, Nyako M, Jeng HH, Bar-Sagi D. Perturbation of cytoskeleton dynamics by the opposing effects of Rac1 and Rac1b. Small Gtpases. 1: 89-97. PMID 21686260 DOI: 10.4161/sgtp.1.2.14427  1
2010 Xu L, Zhou JL, Cohen M, Bar-Sagi D, Patel KN. Spry2 expression correlates with BRAF mutation in thyroid cancer. Surgery. 148: 1282-7; discussion 1. PMID 21134562 DOI: 10.1016/j.surg.2010.09.028  1
2010 Lee KE, Bar-Sagi D. Oncogenic KRas suppresses inflammation-associated senescence of pancreatic ductal cells. Cancer Cell. 18: 448-58. PMID 21075310 DOI: 10.1016/j.ccr.2010.10.020  1
2010 Xu L, Lubkov V, Taylor LJ, Bar-Sagi D. Feedback regulation of Ras signaling by Rabex-5-mediated ubiquitination. Current Biology : Cb. 20: 1372-7. PMID 20655225 DOI: 10.1016/j.cub.2010.06.051  1
2010 Miaczynska M, Bar-Sagi D. Signaling endosomes: seeing is believing. Current Opinion in Cell Biology. 22: 535-40. PMID 20538448 DOI: 10.1016/j.ceb.2010.05.007  1
2010 Yadav KK, Bar-Sagi D. Allosteric gating of Son of sevenless activity by the histone domain. Proceedings of the National Academy of Sciences of the United States of America. 107: 3436-40. PMID 20133694 DOI: 10.1073/pnas.0914315107  1
2010 Gureasko J, Kuchment O, Makino DL, Sondermann H, Bar-Sagi D, Kuriyan J. Role of the histone domain in the autoinhibition and activation of the Ras activator Son of Sevenless Proceedings of the National Academy of Sciences of the United States of America. 107: 3430-3435. PMID 20133692 DOI: 10.1073/pnas.0913915107  1
2010 Connolly MK, Mallen-St Clair J, Bedrosian AS, Malhotra A, Vera V, Ibrahim J, Henning J, Pachter HL, Bar-Sagi D, Frey AB, Miller G. Distinct populations of metastases-enabling myeloid cells expand in the liver of mice harboring invasive and preinvasive intra-abdominal tumor. Journal of Leukocyte Biology. 87: 713-25. PMID 20042467 DOI: 10.1189/jlb.0909607  1
2010 Taylor LJ, Bar-Sagi D. The role of rac and rho in cell cycle progression Handbook of Cell Signaling, 2/E. 2: 1781-1784. DOI: 10.1016/B978-0-12-374145-5.00217-5  1
2009 Ford B, Boykevisch S, Zhao C, Kunzelmann S, Bar-Sagi D, Herrmann C, Nassar N. Characterization of a Ras mutant with identical GDP- and GTP-bound structures . Biochemistry. 48: 11449-57. PMID 19883123 DOI: 10.1021/bi901479b  1
2009 Connolly MK, Bedrosian AS, Mallen-St Clair J, Mitchell AP, Ibrahim J, Stroud A, Pachter HL, Bar-Sagi D, Frey AB, Miller G. In liver fibrosis, dendritic cells govern hepatic inflammation in mice via TNF-alpha. The Journal of Clinical Investigation. 119: 3213-25. PMID 19855130 DOI: 10.1172/JCI37581  1
2009 Grabocka E, Bar-Sagi D. Raf-1 and squamous cell carcinoma: Rok-ing the boat. Cancer Cell. 16: 85-6. PMID 19647217 DOI: 10.1016/j.ccr.2009.07.012  1
2009 Fehrenbacher N, Bar-Sagi D, Philips M. Ras/MAPK signaling from endomembranes. Molecular Oncology. 3: 297-307. PMID 19615955 DOI: 10.1016/j.molonc.2009.06.004  1
2009 Frank MJ, Dawson DW, Bensinger SJ, Hong JS, Knosp WM, Xu L, Balatoni CE, Allen EL, Shen RR, Bar-Sagi D, Martin GR, Teitell MA. Expression of sprouty2 inhibits B-cell proliferation and is epigenetically silenced in mouse and human B-cell lymphomas. Blood. 113: 2478-87. PMID 19147787 DOI: 10.1182/blood-2008-05-156943  1
2008 Qi J, Nakayama K, Gaitonde S, Goydos JS, Krajewski S, Eroshkin A, Bar-Sagi D, Bowtell D, Ronai Z. The ubiquitin ligase Siah2 regulates tumorigenesis and metastasis by HIF-dependent and -independent pathways. Proceedings of the National Academy of Sciences of the United States of America. 105: 16713-8. PMID 18946040 DOI: 10.1073/pnas.0804063105  1
2008 Garcia A, Zheng Y, Zhao C, Toschi A, Fan J, Shraibman N, Brown HA, Bar-Sagi D, Foster DA, Arbiser JL. Honokiol suppresses survival signals mediated by Ras-dependent phospholipase D activity in human cancer cells. Clinical Cancer Research : An Official Journal of the American Association For Cancer Research. 14: 4267-74. PMID 18594009 DOI: 10.1158/1078-0432.CCR-08-0102  1
2008 Ojima I, Chen J, Sun L, Borella CP, Wang T, Miller ML, Lin S, Geng X, Kuznetsova L, Qu C, Gallager D, Zhao X, Zanardi I, Xia S, Horwitz SB, ... ... Bar-Sagi D, et al. Design, synthesis, and biological evaluation of new-generation taxoids. Journal of Medicinal Chemistry. 51: 3203-21. PMID 18465846 DOI: 10.1021/jm800086e  1
2008 Gureasko J, Galush WJ, Boykevisch S, Sondermann H, Bar-Sagi D, Groves JT, Kuriyan J. Membrane-dependent signal integration by the Ras activator Son of sevenless. Nature Structural & Molecular Biology. 15: 452-61. PMID 18454158 DOI: 10.1038/nsmb.1418  1
2008 Terrillon S, Bar-Sagi D. Biochemical and biophysical analyses of Ras modification by ubiquitin. Methods in Enzymology. 438: 259-76. PMID 18413254 DOI: 10.1016/S0076-6879(07)38018-X  1
2007 Yeh BJ, Rutigliano RJ, Deb A, Bar-Sagi D, Lim WA. Rewiring cellular morphology pathways with synthetic guanine nucleotide exchange factors. Nature. 447: 596-600. PMID 17515921 DOI: 10.1038/nature05851  1
2007 Zhao C, Du G, Skowronek K, Frohman MA, Bar-Sagi D. Phospholipase D2-generated phosphatidic acid couples EGFR stimulation to Ras activation by Sos. Nature Cell Biology. 9: 706-12. PMID 17486115 DOI: 10.1038/ncb1594  1
2007 Kim HJ, Taylor LJ, Bar-Sagi D. Spatial regulation of EGFR signaling by Sprouty2. Current Biology : Cb. 17: 455-61. PMID 17320394 DOI: 10.1016/j.cub.2007.01.059  1
2007 Tartaglia M, Pennacchio LA, Zhao C, Yadav KK, Fodale V, Sarkozy A, Pandit B, Oishi K, Martinelli S, Schackwitz W, Ustaszewska A, Martin J, Bristow J, Carta C, Lepri F, ... ... Bar-Sagi D, et al. Gain-of-function SOS1 mutations cause a distinctive form of Noonan syndrome. Nature Genetics. 39: 75-9. PMID 17143282 DOI: 10.1038/ng1939  1
2006 Jura N, Bar-Sagi D. Mapping cellular routes of Ras: a ubiquitin trail. Cell Cycle (Georgetown, Tex.). 5: 2744-7. PMID 17172849  1
2006 Archer H, Jura N, Keller J, Jacobson M, Bar-Sagi D. A mouse model of hereditary pancreatitis generated by transgenic expression of R122H trypsinogen. Gastroenterology. 131: 1844-55. PMID 17087933 DOI: 10.1053/j.gastro.2006.09.049  1
2006 Boykevisch S, Zhao C, Sondermann H, Philippidou P, Halegoua S, Kuriyan J, Bar-Sagi D. Regulation of Ras Signaling Dynamics by Sos-Mediated Positive Feedback Current Biology. 16: 2173-2179. PMID 17084704 DOI: 10.1016/j.cub.2006.09.033  1
2006 Freedman TS, Sondermann H, Friedland GD, Kortemme T, Bar-Sagi D, Marqusee S, Kuriyan J. A Ras-induced conformational switch in the Ras activator Son of sevenless. Proceedings of the National Academy of Sciences of the United States of America. 103: 16692-7. PMID 17075039 DOI: 10.1073/pnas.0608127103  1
2006 Agbunag C, Lee KE, Buontempo S, Bar-Sagi D. Pancreatic duct epithelial cell isolation and cultivation in two-dimensional and three-dimensional culture systems. Methods in Enzymology. 407: 703-10. PMID 16757363 DOI: 10.1016/S0076-6879(05)07055-2  1
2006 Jura N, Scotto-Lavino E, Sobczyk A, Bar-Sagi D. Differential modification of Ras proteins by ubiquitination. Molecular Cell. 21: 679-87. PMID 16507365 DOI: 10.1016/j.molcel.2006.02.011  1
2006 Nikolić DL, Boettiger AN, Bar-Sagi D, Carbeck JD, Shvartsman SY. Role of boundary conditions in an experimental model of epithelial wound healing. American Journal of Physiology. Cell Physiology. 291: C68-75. PMID 16495370 DOI: 10.1152/ajpcell.00411.2005  1
2006 DaSilva J, Xu L, Kim HJ, Miller WT, Bar-Sagi D. Regulation of sprouty stability by Mnk1-dependent phosphorylation. Molecular and Cellular Biology. 26: 1898-907. PMID 16479008 DOI: 10.1128/MCB.26.5.1898-1907.2006  1
2005 Sondermann H, Zhao C, Bar-Sagi D. Analysis of Ras:RasGEF interactions by phage display and static multi-angle light scattering. Methods (San Diego, Calif.). 37: 197-202. PMID 16288886 DOI: 10.1016/j.ymeth.2005.05.016  1
2005 Sondermann H, Nagar B, Bar-Sagi D, Kuriyan J. Computational docking and solution x-ray scattering predict a membrane-interacting role for the histone domain of the Ras activator son of sevenless Proceedings of the National Academy of Sciences of the United States of America. 102: 16632-16637. PMID 16267129 DOI: 10.1073/pnas.0508315102  1
2005 Sparmann A, Bar-Sagi D. Ras oncogene and inflammation: partners in crime. Cell Cycle (Georgetown, Tex.). 4: 735-6. PMID 15908805  1
2005 Ford B, Skowronek K, Boykevisch S, Bar-Sagi D, Nassar N. Structure of the G60A mutant of Ras: implications for the dominant negative effect. The Journal of Biological Chemistry. 280: 25697-705. PMID 15878843 DOI: 10.1074/jbc.M502240200  1
2005 Jura N, Archer H, Bar-Sagi D. Chronic pancreatitis, pancreatic adenocarcinoma and the black box in-between. Cell Research. 15: 72-7. PMID 15686632 DOI: 10.1038/sj.cr.7290269  1
2004 Sparmann A, Bar-Sagi D. Ras-induced interleukin-8 expression plays a critical role in tumor growth and angiogenesis. Cancer Cell. 6: 447-58. PMID 15542429 DOI: 10.1016/j.ccr.2004.09.028  1
2004 Sondermann H, Soisson SM, Boykevisch S, Yang SS, Bar-Sagi D, Kuriyan J. Structural analysis of autoinhibition in the Ras activator son of sevenless Cell. 119: 393-405. PMID 15507210 DOI: 10.1016/j.cell.2004.10.005  1
2004 Agbunag C, Bar-Sagi D. Oncogenic K-ras drives cell cycle progression and phenotypic conversion of primary pancreatic duct epithelial cells. Cancer Research. 64: 5659-63. PMID 15313904 DOI: 10.1158/0008-5472.CAN-04-0807  1
2004 Kim HJ, Bar-Sagi D. Modulation of signalling by Sprouty: a developing story. Nature Reviews. Molecular Cell Biology. 5: 441-50. PMID 15173823 DOI: 10.1038/nrm1400  1
2003 Sondermann H, Soisson SM, Bar-Sagi D, Kuriyan J. Tandem Histone Folds in the Structure of the N-Terminal Segment of the Ras Activator Son of Sevenless Structure. 11: 1583-1593. PMID 14656442 DOI: 10.1016/j.str.2003.10.015  1
2003 Kennedy NJ, Sluss HK, Jones SN, Bar-Sagi D, Flavell RA, Davis RJ. Suppression of Ras-stimulated transformation by the JNK signal transduction pathway. Genes & Development. 17: 629-37. PMID 12629045 DOI: 10.1101/gad.1062903  1
2003 Margarit SM, Sondermann H, Hall BE, Nagar B, Hoelz A, Pirruccello M, Bar-Sagi D, Kuriyan J. Structural evidence for feedback activation by Ras.GTP of the Ras-specific nucleotide exchange factor SOS. Cell. 112: 685-95. PMID 12628188 DOI: 10.1016/S0092-8674(03)00149-1  1
2003 Guo H, Seixas-Silva JA, Epperly MW, Gretton JE, Shin DM, Bar-Sagi D, Archer H, Greenberger JS. Prevention of radiation-induced oral cavity mucositis by plasmid/liposome delivery of the human manganese superoxide dismutase (SOD2) transgene. Radiation Research. 159: 361-70. PMID 12600239 DOI: 10.1667/0033-7587(2003)159[0361:PORIOC]2.0.CO;2  1
2003 Nimnual AS, Taylor LJ, Bar-Sagi D. Redox-dependent downregulation of Rho by Rac. Nature Cell Biology. 5: 236-41. PMID 12598902 DOI: 10.1038/ncb938  1
2003 Hall AB, Jura N, DaSilva J, Jang YJ, Gong D, Bar-Sagi D. hSpry2 is targeted to the ubiquitin-dependent proteasome pathway by c-Cbl. Current Biology : Cb. 13: 308-14. PMID 12593796 DOI: 10.1016/S0960-9822(03)00086-1  1
2003 Epperly MW, Guo HL, Jefferson M, Nie S, Gretton J, Bernarding M, Bar-Sagi D, Archer H, Greenberger JS. Cell phenotype specific kinetics of expression of intratracheally injected manganese superoxide dismutase-plasmid/liposomes (MnSOD-PL) during lung radioprotective gene therapy Gene Therapy. 10: 163-171. DOI: 10.1038/sj.gt.3301852  1
2002 Nahle Z, Polakoff J, Davuluri RV, McCurrach ME, Jacobson MD, Narita M, Zhang MQ, Lazebnik Y, Bar-Sagi D, Lowe SW. Direct coupling of the cell cycle and cell death machinery by E2F. Nature Cell Biology. 4: 859-64. PMID 12389032 DOI: 10.1038/ncb868  1
2002 Farhang-Fallah J, Randhawa VK, Nimnual A, Klip A, Bar-Sagi D, Rozakis-Adcock M. The pleckstrin homology (PH) domain-interacting protein couples the insulin receptor substrate 1 PH domain to insulin signaling pathways leading to mitogenesis and GLUT4 translocation. Molecular and Cellular Biology. 22: 7325-36. PMID 12242307 DOI: 10.1128/MCB.22.20.7325-7336.2002  1
2002 Hall BE, Bar-Sagi D, Nassar N. The structural basis for the transition from Ras-GTP to Ras-GDP. Proceedings of the National Academy of Sciences of the United States of America. 99: 12138-42. PMID 12213964 DOI: 10.1073/pnas.192453199  1
2002 Nimnual A, Bar-Sagi D. The two hats of SOS. Science's Stke : Signal Transduction Knowledge Environment. 2002: pe36. PMID 12177507 DOI: 10.1126/stke.2002.145.pe36  1
2002 Archer H, Bar-Sagi D. Ras and Rac as activators of reactive oxygen species (ROS). Methods in Molecular Biology (Clifton, N.J.). 189: 67-73. PMID 12094595 DOI: 10.1385/1-59259-281-3:067  1
2002 Lei K, Nimnual A, Zong WX, Kennedy NJ, Flavell RA, Thompson CB, Bar-Sagi D, Davis RJ. The Bax subfamily of Bcl2-related proteins is essential for apoptotic signal transduction by c-Jun NH(2)-terminal kinase. Molecular and Cellular Biology. 22: 4929-42. PMID 12052897 DOI: 10.1128/MCB.22.13.4929-4942.2002  1
2002 Epperly MW, Sikora CA, DeFilippi SJ, Gretton JE, Bar-Sagi D, Archer H, Carlos T, Guo H, Greenberger JS. Pulmonary irradiation-induced expression of VCAM-I and ICAM-I is decreased by manganese superoxide dismutase-plasmid/liposome (MnSOD-PL) gene therapy. Biology of Blood and Marrow Transplantation : Journal of the American Society For Blood and Marrow Transplantation. 8: 175-87. PMID 12014807  1
2002 Egan JE, Hall AB, Yatsula BA, Bar-Sagi D. The bimodal regulation of epidermal growth factor signaling by human Sprouty proteins. Proceedings of the National Academy of Sciences of the United States of America. 99: 6041-6. PMID 11983899 DOI: 10.1073/pnas.052090899  1
2002 Hall BE, Yang SS, Bar-Sagi D. Autoinhibition of Sos by intramolecular interactions. Frontiers in Bioscience : a Journal and Virtual Library. 7: d288-94. PMID 11779695  1
2001 Lu W, Gong D, Bar-Sagi D, Cole PA. Site-specific incorporation of a phosphotyrosine mimetic reveals a role for tyrosine phosphorylation of SHP-2 in cell signaling Molecular Cell. 8: 759-769. PMID 11684012 DOI: 10.1016/S1097-2765(01)00369-0  1
2001 Faruqi TR, Gomez D, Bustelo XR, Bar-Sagi D, Reich NC. Rac1 mediates STAT3 activation by autocrine IL-6. Proceedings of the National Academy of Sciences of the United States of America. 98: 9014-9. PMID 11470914 DOI: 10.1073/pnas.161281298  1
2001 Hall BE, Yang SS, Boriack-Sjodin PA, Kuriyan J, Bar-Sagi D. Structure-based mutagenesis reveals distinct functions for Ras switch 1 and switch 2 in Sos-catalyzed guanine nucleotide exchange. The Journal of Biological Chemistry. 276: 27629-37. PMID 11333268 DOI: 10.1074/jbc.M101727200  1
2001 Walsh AB, Bar-Sagi D. Differential Activation of the Rac Pathway by Ha-Ras and K-Ras Journal of Biological Chemistry. 276: 15609-15615. PMID 11278702 DOI: 10.1074/jbc.M010573200  1
2001 Bar-Sagi D. A ras by any other name Molecular and Cellular Biology. 21: 1441-1443. PMID 11238880 DOI: 10.1128/MCB.21.5.1441-1443.2001  1
2000 Bar-Sagi D, Hall A. Ras and Rho GTPases: A family reunion Cell. 103: 227-238. PMID 11057896 DOI: 10.1016/S0092-8674(00)00115-X  1
2000 Taylor LJ, Walsh AB, Hearing P, Bar-Sagi D. Single cell assays for Rac activity Methods in Enzymology. 325: 327-334. PMID 11036615  1
2000 Tournier C, Hess P, Yang DD, Xu J, Turner TK, Nimnual A, Bar-Sagi D, Jones SN, Flavell RA, Davis RJ. Requirement of JNK for stress-induced activation of the cytochrome c- mediated death pathway Science. 288: 870-874. PMID 10797012 DOI: 10.1126/science.288.5467.870  1
2000 Schaley J, O'Connor RJ, Taylor LJ, Bar-Sagi D, Hearing P. Induction of the cellular E2F-1 promoter by the adenovirus E4-6/7 protein Journal of Virology. 74: 2084-2093. PMID 10666238 DOI: 10.1128/JVI.74.5.2084-2093.2000  1
1999 Kumar CC, Ohashi K, Nagata K, Walsh A, Bar-Sagi D, Mizuno K. SCH 51334, an inhibitor of RAS/RAC-mediated cell morphology pathway Annals of the New York Academy of Sciences. 886: 122-131. PMID 10667210  1
1999 Weber JD, Taylor LJ, Roussel MF, Sherr CJ, Bar-Sagi D. Nucleolar Arf sequesters Mdm2 and activates p53. Nature Cell Biology. 1: 20-6. PMID 10559859 DOI: 10.1038/8991  1
1999 Joneson T, Bar-Sagi D. Suppression of Ras-induced apoptosis by the Rac GTPpase Molecular and Cellular Biology. 19: 5892-5901. PMID 10454536  1
1998 Soisson SM, Nimnual AS, Uy M, Bar-Sagi D, Kuriyan J. Crystal structure of the Dbl and pleckstrin homology domains from the human Son of sevenless protein. Cell. 95: 259-68. PMID 9790532 DOI: 10.1016/S0092-8674(00)81756-0  1
1998 Boriack-Sjodin PA, Margarit SM, Bar-Sagi D, Kuriyan J. The structural basis of the activation of Ras by Sos. Nature. 394: 337-43. PMID 9690470 DOI: 10.1038/28548  1
1998 Joneson T, Bar-Sagi D. A Rac1 effector site controlling mitogenesis through superoxide production Journal of Biological Chemistry. 273: 17991-17994. PMID 9660749 DOI: 10.1074/jbc.273.29.17991  1
1998 Joneson T, Fulton JA, Volle DJ, Chaika OV, Bar-Sagi D, Lewis RE. Kinase suppressor of Ras inhibits the activation of extracellular ligand-regulated (ERK) mitogen-activated protein (MAP) kinase by growth factors, activated Ras, and Ras effectors. The Journal of Biological Chemistry. 273: 7743-8. PMID 9516483 DOI: 10.1074/jbc.273.13.7743  1
1998 Corbalan-Garcia S, Margarit SM, Galron D, Yang SS, Bar-Sagi D. Regulation of Sos activity by intramolecular interactions. Molecular and Cellular Biology. 18: 880-6. PMID 9447984  1
1998 Nimnual AS, Yatsula BA, Bar-Sagi D. Coupling of Ras and Rac guanosine triphosphatases through the Ras exchanger Sos Science. 279: 560-563. PMID 9438849 DOI: 10.1126/science.279.5350.560  1
1998 Zheng J, Chen HC, Corblan-Garcia S, Cahill SM, Bar-Sagi D, Cowburn D. The solution structure of the pleckstrin homology domain of human SOS1: A possible structural role for the sequential association of DHL homology domain and pleckstrin homology domains Faseb Journal. 12.  1
1997 Walsh AB, Dhanasekaran M, Bar-Sagi D, Kumar CC. SCH 51344-induced reversal of RAS-transformation is accompanied by the specific inhibition of the RAS and RAC-dependent cell morphology pathway. Oncogene. 15: 2553-60. PMID 9399643 DOI: 10.1038/sj.onc.1201424  1
1997 Colley WC, Sung TC, Roll R, Jenco J, Hammondt SM, Altshuller Y, Bar-Sagi D, Morris AJ, Frohman MA. Phospholipase D2, a distinct phospholipase D isoform with novel regulatory properties that provokes cytoskeletal reorganization Current Biology. 7: 191-201. PMID 9395408  1
1997 Zheng J, Chen RH, Corblan-Garcia S, Cahill SM, Bar-Sagi D, Cowburn D. The solution structure of the pleckstrin homology domain of human SOS1. A possible structural role for the sequential association of diffuse B cell lymphoma and pleckstrin homology domains Journal of Biological Chemistry. 272: 30340-30344. PMID 9374522 DOI: 10.1074/jbc.272.48.30340  1
1997 Joneson T, Bar-Sagi D. Ras effectors and their role in mitogenesis and oncogenesis Journal of Molecular Medicine. 75: 587-593. PMID 9297626 DOI: 10.1007/s001090050143  1
1997 Kouhara H, Hadari YR, Spivak-Kroizman T, Schilling J, Bar-Sagi D, Lax I, Schlessinger J. A lipid-anchored Grb2-binding protein that links FGF-receptor activation to the Ras/MAPK signaling pathway. Cell. 89: 693-702. PMID 9182757  1
1997 Chen RH, Corbalan-Garcia S, Bar-Sagi D. The role of the PH domain in the signal-dependent membrane targeting of Sos Embo Journal. 16: 1351-1359. PMID 9135150 DOI: 10.1093/emboj/16.6.1351  1
1997 Joneson T, Bar-Sagi D. Small gtpase cascades and growth control Faseb Journal. 11.  1
1996 Joneson T, McDonough M, Bar-Sagi D, Van Aelst L. RAC regulation of actin polymerization and proliferation by a pathway distinct from Jun kinase. Science (New York, N.Y.). 274: 1374-6. PMID 8910277 DOI: 10.1126/science.274.5291.1374  1
1996 Corbalan-Garcia S, Yang SS, Degenhardt KR, Bar-Sagi D. Identification of the mitogen-activated protein kinase phosphorylation sites on human Sos1 that regulate interaction with Grb2 Molecular and Cellular Biology. 16: 5674-5682. PMID 8816480  1
1996 Van Aelst L, Joneson T, Bar-Sagi D. Identification of a novel Rac1-interacting protein involved in membrane ruffling. The Embo Journal. 15: 3778-86. PMID 8670882  1
1996 Corbalan-Garcia S, Degenhardt KR, Bar-Sagi D. Insulin-induced dissociation of Sos from Grb2 does not contribute to the down regulation of Ras activation Oncogene. 12: 1063-1068. PMID 8649797  1
1996 Joneson T, White MA, Wigler MH, Bar-Sagi D. Stimulation of membrane ruffling and MAP kinase activation by distinct effectors of RAS. Science (New York, N.Y.). 271: 810-2. PMID 8628998  1
1996 Macara IG, Lounsbury KM, Richards SA, Mckiernan C, Bar-Sagi D. The Ras superfamily of GTPases Faseb Journal. 10: 625-630. PMID 8621061  1
1996 Collins TL, Bonnefoy-Berard N, Baier-Bitterlich G, Baier G, Burn F, Bar-Sagi D, Altman A. CD4 associates with SOS, a RAS regulatory protein Faseb Journal. 10.  1
1995 Bar-Sagi D. Mammalian cell microinjection assay Methods in Enzymology. 255: 436-442. PMID 8524129 DOI: 10.1016/S0076-6879(95)55045-3  1
1995 Frech M, Cussac D, Chardin P, Bar-Sagi D. Purification of baculovirus-expressed human Sos1 protein Methods in Enzymology. 255: 125-129. PMID 8524094 DOI: 10.1016/S0076-6879(95)55015-1  1
1995 Serrano M, Gómez-Lahoz E, DePinho RA, Beach D, Bar-Sagi D. Inhibition of ras-induced proliferation and cellular transformation by p16INK4 Science. 267: 249-252. PMID 7809631  1
1995 Yang SS, Van Aelst L, Bar-Sagi D. Differential interactions of human Sos1 and Sos2 with Grb2. The Journal of Biological Chemistry. 270: 18212-5. PMID 7629138 DOI: 10.1074/jbc.270.31.18212  1
1994 Boyer MJ, Gutmann DH, Collins FS, Bar-Sagi D. Crosslinking of the surface immunoglobulin receptor in B lymphocytes induces a redistribution of neurofibromin but not p120-GAP Oncogene. 9: 349-357. PMID 8290249  1
1994 Sun H, Tonks NK, Bar-Sagi D. Inhibition of Ras-induced DNA synthesis by expression of the phosphatase MKP-1 Science. 266: 285-288. PMID 7939666 DOI: 10.1126/science.7939666  1
1994 Rotin D, Bar-Sagi D, O'Brodovich H, Merilainen J, Lehto VP, Canessa CM, Rossier BC, Downey GP. An SH3 binding region in the epithelial Na+ channel (alpha rENaC) mediates its localization at the apical membrane. The Embo Journal. 13: 4440-50. PMID 7925286  1
1994 Schlessinger J, Bar-Sagi D. Activation of Ras and other signaling pathways by receptor tyrosine kinases. Cold Spring Harbor Symposia On Quantitative Biology. 59: 173-9. PMID 7587067  1
1994 Bar-Sagi D. The Sos (Son of sevenless) protein Trends in Endocrinology and Metabolism. 5: 165-169. DOI: 10.1016/1043-2760(94)90014-0  1
1993 Chardin P, Camonis JH, Gale NW, van Aelst L, Schlessinger J, Wigler MH, Bar-Sagi D. Human Sos1: a guanine nucleotide exchange factor for Ras that binds to GRB2. Science (New York, N.Y.). 260: 1338-43. PMID 8493579  1
1993 Li N, Batzer A, Daly R, Yajnik V, Skolnik E, Chardin P, Bar-Sagi D, Margolis B, Schlessinger J. Guanine-nucleotide-releasing factor hSos1 binds to Grb2 and links receptor tyrosine kinases to Ras signalling. Nature. 363: 85-8. PMID 8479541 DOI: 10.1038/363085a0  1
1993 Gale NW, Kaplan S, Lowenstein EJ, Schlessinger J, Bar-Sagi D. Grb2 mediates the EGF-dependent activation of guanine nucleotide exchange on Ras. Nature. 363: 88-92. PMID 8386805 DOI: 10.1038/363088a0  1
1993 Quelle DE, Ashmun RA, Shurtleff SA, Kato JY, Bar-Sagi D, Roussel MF, Sherr CJ. Overexpression of mouse D-type cyclins accelerates G1 phase in rodent fibroblasts Genes and Development. 7: 1559-1571. PMID 8339933  1
1993 Bar-Sagi D, Rotin D, Batzer A, Mandiyan V, Schlessinger J. SH3 domains direct cellular localization of signaling molecules. Cell. 74: 83-91. PMID 8334708 DOI: 10.1016/0092-8674(93)90296-3  1
1993 Hide I, Bennett JP, Pizzey A, Boonen G, Bar-Sagi D, Gomperts BD, Tatham PER. Degranulation of individual mast cells in response to Ca2+ and guanine nucleotides: An all-or-none event Journal of Cell Biology. 123: 585-593. PMID 8227127  1
1992 Bar-Sagi D. Mechanisms of signal transduction by Ras Seminars in Cell Biology. 3: 93-98. PMID 1611045  1
1992 Portilla D, Mandel LJ, Bar-Sagi D, Millington DS. Anoxia induces phospholipase A2 activation in rabbit renal proximal tubules American Journal of Physiology - Renal Fluid and Electrolyte Physiology. 262. PMID 1558154  1
1992 Lowenstein EJ, Daly RJ, Batzer AG, Li W, Margolis B, Lammers R, Ullrich A, Skolnik EY, Bar-Sagi D, Schlessinger J. The SH2 and SH3 domain-containing protein GRB2 links receptor tyrosine kinases to ras signaling. Cell. 70: 431-42. PMID 1322798 DOI: 10.1016/0092-8674(92)90167-B  1
1991 Bar-Sagi D. Phospholipase A2: Microinjection and cell localization techniques Methods in Enzymology. 197: 269-279. PMID 2051920  1
1991 Kaplan S, Bar-Sagi D. Association of p21ras with cellular polypeptides Journal of Biological Chemistry. 266: 18934-18941. PMID 1918009  1
1991 Graziadei L, Burfeind P, Bar-Sagi D. Introduction of unlabeled proteins into living cells by electroporation and isolation of viable protein-loaded cells using dextran-fluorescein isothiocyanate as a marker for protein uptake Analytical Biochemistry. 194: 198-203. PMID 1714252 DOI: 10.1016/0003-2697(91)90168-S  1
1990 Cockcroft S, Bar-Sagi D. Effects of H-ras proteins on the activity of polyphosphoinositide phospholipase C in HL60 membranes Cellular Signalling. 2: 227-234. PMID 2169290 DOI: 10.1016/0898-6568(90)90050-K  1
1990 Graziadei L, Riabowol K, Bar-Sagi D. Co-capping of ras proteins with surface immunoglobulins in B lymphocytes. Nature. 347: 396-400. PMID 2120590 DOI: 10.1038/347396a0  1
1989 Bar-Sagi D. Ras proteins: Biological effects and biochemical targets (Review) Anticancer Research. 9: 1427-1438. PMID 2686537  1
1989 Kim D, Lewis DL, Graziadei L, Neer EJ, Bar-Sagi D, Clapham DE. G-protein beta gamma-subunits activate the cardiac muscarinic K+-channel via phospholipase A2. Nature. 337: 557-60. PMID 2492640 DOI: 10.1038/337557a0  1
1988 Bar-Sagi D, Suhan JP, McCormick F, Feramisco JR. Localization of phospholipase A2 in normal and ras-transformed cells Journal of Cell Biology. 106: 1649-1658. PMID 3286660  1
1988 Bar-Sagi D, Gomperts BD. Stimulation of exocytotic degranulation by microinjection of the ras oncogene protein into rat mast cells Oncogene. 3: 463-469. PMID 3078954  1
1987 Bar-Sagi D, McCormick F, Milley RJ, Feramisco JR. Inhibition of cell surface ruffling and fluid-phase pinocytosis by microinjection of anti-ras antibodies into living cells Journal of Cellular Physiology. 133: 69-73. PMID 3316255  1
1987 Bar-Sagi D, Fernandez A, Feramisco JR. Regulation of membrane turnover by ras proteins Bioscience Reports. 7: 427-434. PMID 3315033 DOI: 10.1007/BF01362505  1
1986 Bar-Sagi D, Feramisco JR. Induction of membrane ruffling and fluid-phase pinocytosis in quiescent fibroblasts by ras proteins Science. 233: 1061-1068. PMID 3090687  1
1985 Bar-Sagi D, Feramisco JR. Microinjection of the ras oncogene protein into PC12 cells induces morphological differentiation Cell. 42: 841-848. PMID 2996779 DOI: 10.1016/0092-8674(85)90280-6  1
1985 Bar-Sagi D, Prives J. Negative modulation of sodium channels in cultured chick muscle cells by the channel activator batrachotoxin Journal of Biological Chemistry. 260: 4740-4744. PMID 2580827  1
1983 Bar-Sagi D, Prives J. Tunicamycin inhibits the expression of surface Na+ channels in cultured muscle cells Journal of Cellular Physiology. 114: 77-81. PMID 6298252 DOI: 10.1002/jcp.1041140113  1
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