John A. Porco, Jr. - Publications

Affiliations: 
Boston University, Boston, MA, United States 
Area:
synthesis of complex natural products
Website:
http://www.bu.edu/chemistry/faculty/porco/

138 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2021 Xu W, Brown LE, Porco JA. Divergent, C-C Bond Forming Macrocyclizations Using Modular Sulfonylhydrazone and Derived Substrates. The Journal of Organic Chemistry. PMID 34730970 DOI: 10.1021/acs.joc.1c01848  0.575
2021 Chatterjee S, Yabaji SM, Rukhlenko OS, Bhattacharya B, Waligurski E, Vallavoju N, Ray S, Kholodenko BN, Brown LE, Beeler AB, Ivanov AR, Kobzik L, Porco JA, Kramnik I. Channeling macrophage polarization by rocaglates increases macrophage resistance to . Iscience. 24: 102845. PMID 34381970 DOI: 10.1016/j.isci.2021.102845  0.414
2020 Iyer KR, Camara K, Daniel-Ivad M, Trilles R, Pimentel-Elardo SM, Fossen JL, Marchillo K, Liu Z, Singh S, Muñoz JF, Kim SH, Porco JA, Cuomo CA, Williams NS, Ibrahim AS, et al. An oxindole efflux inhibitor potentiates azoles and impairs virulence in the fungal pathogen Candida auris. Nature Communications. 11: 6429. PMID 33353950 DOI: 10.1038/s41467-020-20183-3  0.459
2020 Levi-Galibov O, Lavon H, Wassermann-Dozorets R, Pevsner-Fischer M, Mayer S, Wershof E, Stein Y, Brown LE, Zhang W, Friedman G, Nevo R, Golani O, Katz LH, Yaeger R, Laish I, ... Porco JA, et al. Heat Shock Factor 1-dependent extracellular matrix remodeling mediates the transition from chronic intestinal inflammation to colon cancer. Nature Communications. 11: 6245. PMID 33288768 DOI: 10.1038/s41467-020-20054-x  0.42
2020 Boyce JH, Reisman BJ, Bachmann BO, Porco JA. Synthesis and Multiplexed Activity Profiling of Synthetic Acylphloroglucinol Scaffolds. Angewandte Chemie (International Ed. in English). PMID 32965753 DOI: 10.1002/anie.202010338  0.797
2020 Iyer KR, Whitesell L, Porco JA, Henkel T, Brown LE, Robbins N, Cowen LE. Translation Inhibition by Rocaglates Activates a Species-Specific Cell Death Program in the Emerging Fungal Pathogen Candida auris. Mbio. 11. PMID 32156828 DOI: 10.1128/Mbio.03329-19  0.502
2020 Chu J, Zhang W, Cencic R, O'Connor PBF, Robert F, Devine WG, Selznick A, Henkel T, Merrick WC, Brown LE, Baranov PV, Porco JA, Pelletier J. Rocaglates Induce Gain-of-Function Alterations to eIF4A and eIF4F. Cell Reports. PMID 32101697 DOI: 10.1016/J.Celrep.2020.02.002  0.475
2020 Lehman SL, Wechsler T, Schwartz KR, Wahba A, Brown LE, Porco JA, Pelletier J, Camphausen K, Tofilon PJ. Abstract 6507: Inhibition of the translation initiation factor eIF4A1 enhances tumor cell radiosensitivity Cancer Research. 80: 6507-6507. DOI: 10.1158/1538-7445.Am2020-6507  0.476
2019 Chan K, Robert F, Oertlin C, Kapeller-Libermann D, Avizonis D, Gutierrez J, Handly-Santana A, Doubrovin M, Park J, Schoepfer C, Da Silva B, Yao M, Gorton F, Shi J, Thomas CJ, ... ... Porco JA, et al. eIF4A supports an oncogenic translation program in pancreatic ductal adenocarcinoma. Nature Communications. 10: 5151. PMID 31723131 DOI: 10.1038/S41467-019-13086-5  0.464
2019 Chu J, Zhang W, Cencic R, Devine WG, Beglov D, Henkel T, Brown LE, Vajda S, Porco JA, Pelletier J. Amidino-Rocaglates: A Potent Class of eIF4A Inhibitors. Cell Chemical Biology. PMID 31519508 DOI: 10.1016/J.Chembiol.2019.08.008  0.501
2019 Porco J, Powers Z, Scharf A, Cheng A, Yang F, Himmelbauer M, Mitsuhashi T, Barra L, Taniguchi Y, Kikuchi T, Fujita M, Abe I. Biomimetic Synthesis of Meroterpenoids by Dearomatization- Driven Polycyclization. Angewandte Chemie (International Ed. in English). PMID 31515901 DOI: 10.1002/Anie.201910710  0.317
2019 Zhang W, Chu J, Cyr AM, Yueh H, Brown LE, Wang TT, Pelletier J, Porco JA. Intercepted Retro-Nazarov Reaction: Syntheses of Amidino-Rocaglate Derivatives and Their Biological Evaluation as eIF4A Inhibitors. Journal of the American Chemical Society. PMID 31310112 DOI: 10.1021/Jacs.9B06446  0.586
2019 Wen S, Boyce JH, Kandappa SK, Sivaguru J, Porco JA. Regiodivergent Photocyclization of Dearomatized Acylphloroglucinols: Asymmetric Syntheses of (-)-Nemorosone and (-)-6- epi-Garcimultiflorone A. Journal of the American Chemical Society. PMID 31264859 DOI: 10.1021/Jacs.9B05600  0.777
2019 Zhang X, Bi C, Lu T, Zhang W, Yue T, Wang C, Tian T, Zhang X, Huang Y, Lunning M, Hao X, Brown LE, Devine WG, Vose J, Porco JA, et al. Targeting translation initiation by synthetic rocaglates for treating MYC-driven lymphomas. Leukemia. PMID 31171817 DOI: 10.1038/S41375-019-0503-Z  0.515
2019 Chen CD, Zeldich E, Khodr C, Camara K, Tung TY, Lauder EC, Mullen P, Polanco TJ, Liu YY, Zeldich D, Xia W, Van Nostrand WE, Brown LE, Porco JA, Abraham CR. Small Molecule Amyloid-β Protein Precursor Processing Modulators Lower Amyloid-β Peptide Levels via cKit Signaling. Journal of Alzheimer's Disease : Jad. 67: 1089-1106. PMID 30776010 DOI: 10.3233/Jad-180923  0.453
2019 Itoua Maïga R, Cencic R, Chu J, Waller DD, Brown LE, Devine WG, Zhang W, Sebag M, Porco JA, Pelletier J. Oxo-aglaiastatin-Mediated Inhibition of Translation Initiation. Scientific Reports. 9: 1265. PMID 30718665 DOI: 10.1038/S41598-018-37666-5  0.531
2019 Porco J, Qin XJ, Rauwolf T, Li PP, Li H, McNeely J, Hua Y, Liu HY. Isolation and Synthesis of Novel Meroterpenoids from Rhodomyrtus tomentosa: Investigation of a Reactive Enetrione Intermediate. Angewandte Chemie (International Ed. in English). PMID 30681258 DOI: 10.1002/anie.201814421  0.317
2019 Whitesell L, Robbins N, Huang DS, McLellan CA, Shekhar-Guturja T, LeBlanc EV, Nation CS, Hui R, Hutchinson A, Collins C, Chatterjee S, Trilles R, Xie JL, Krysan DJ, Lindquist S, ... Porco JA, et al. Structural basis for species-selective targeting of Hsp90 in a pathogenic fungus. Nature Communications. 10: 402. PMID 30679438 DOI: 10.1038/s41467-018-08248-w  0.471
2019 Trilles R, Beglov D, Chen Q, He H, Wireman R, Reed A, Chennamadhavuni S, Panek JS, Brown LE, Vajda S, Porco JA, Kelley MR, Georgiadis MM. Discovery of macrocyclic inhibitors of Apurinic/apyrimidinic endonuclease 1. Journal of Medicinal Chemistry. PMID 30653918 DOI: 10.1021/Acs.Jmedchem.8B01529  0.786
2018 Kearney SE, Zahoránszky-Kőhalmi G, Brimacombe KR, Henderson MJ, Lynch C, Zhao T, Wan KK, Itkin Z, Dillon C, Shen M, Cheff DM, Lee TD, Bougie D, Cheng K, Coussens NP, ... ... Porco JA, et al. Canvass: A Crowd-Sourced, Natural-Product Screening Library for Exploring Biological Space. Acs Central Science. 4: 1727-1741. PMID 30648156 DOI: 10.1021/Acscentsci.8B00747  0.736
2018 Zhang W, Liu S, Maiga RI, Pelletier J, Brown LE, Wang TT, Porco JA. Chemical Synthesis Enables Structural Reengineering of Aglaroxin C Leading to Inhibition Bias for HCV Infection. Journal of the American Chemical Society. PMID 30590924 DOI: 10.1021/Jacs.8B11477  0.559
2018 Smith MJ, Reichl KD, Escobar RA, Heavey T, Coker DF, Schaus SE, Porco JA. Asymmetric Synthesis of Griffipavixanthone Employing a Chiral Phosphoric Acid-Catalyzed Cycloaddition. Journal of the American Chemical Society. PMID 30566336 DOI: 10.1021/Jacs.8B12520  0.799
2018 Nalli AD, Brown LE, Thomas CL, Sayers TJ, Porco JA, Henrich CJ. Sensitization of renal carcinoma cells to TRAIL-induced apoptosis by rocaglamide and analogs. Scientific Reports. 8: 17519. PMID 30504817 DOI: 10.1038/S41598-018-35908-0  0.475
2018 Chennamadhavuni S, Panek JS, Porco JA, Brown LE. Diastereodivergent synthesis of chiral tetrahydropyrrolodiazepinediones via a one-pot intramolecular aza-Michael/lactamization sequence. The Journal of Organic Chemistry. PMID 30458107 DOI: 10.1021/Acs.Joc.8B02724  0.808
2018 Yang X, Jounaidi Y, Dai JB, Marte-Oquendo F, Halpin ES, Brown LE, Trilles R, Xu W, Daigle R, Yu B, Schaus SE, Porco JA, Forman SA. High-throughput Screening in Larval Zebrafish Identifies Novel Potent Sedative-hypnotics. Anesthesiology. PMID 29894316 DOI: 10.1097/Aln.0000000000002281  0.536
2018 Langlais D, Cencic R, Moradin N, Kennedy JM, Ayi K, Brown LE, Crandall I, Tarry MJ, Schmeing M, Kain KC, Porco JA, Pelletier J, Gros P. Rocaglates as dual-targeting agents for experimental cerebral malaria. Proceedings of the National Academy of Sciences of the United States of America. PMID 29463745 DOI: 10.1073/Pnas.1713000115  0.463
2018 Porco J, Qi C, Wang W, Reichl K, McNeely J. Total Synthesis of Aurofusarin: Studies of the Atropisomeric Stability of Bis-Naphthoquinones. Angewandte Chemie (International Ed. in English). PMID 29318760 DOI: 10.1002/Anie.201711535  0.686
2017 Porco J, Wang W, Clay A, Krishnan R, Lajkiewicz NJ, Brown LE, Sivaguru J. Total Syntheses of the Isomeric Aglain Natural Products Foveoglin A and Perviridisin B via Selective ESIPT Photocycloaddition. Angewandte Chemie (International Ed. in English). PMID 28950418 DOI: 10.1002/Anie.201707539  0.788
2017 Reichl KD, Smith MJ, Song MK, Johnson R, Porco JA. Biomimetic Total Synthesis of (±)-Griffipavixanthone via a Cationic Cycloaddition-Cyclization Cascade. Journal of the American Chemical Society. PMID 28942643 DOI: 10.1021/Jacs.7B09265  0.331
2017 Manier S, Huynh D, Shen YJ, Zhou J, Yusufzai T, Salem KZ, Ebright RY, Shi J, Park J, Glavey SV, Devine WG, Liu CJ, Leleu X, Quesnel B, Roche-Lestienne C, ... ... Porco JA, et al. Inhibiting the oncogenic translation program is an effective therapeutic strategy in multiple myeloma. Science Translational Medicine. 9. PMID 28490664 DOI: 10.1126/Scitranslmed.Aal2668  0.658
2016 Hayashi M, Brown LE, Porco JA. Asymmetric Dearomatization/Cyclization Enables Access to Polycyclic Chemotypes. European Journal of Organic Chemistry. 2016: 4800-4804. PMID 28082832 DOI: 10.1002/Ejoc.201601003  0.528
2016 Ingham OJ, Paranal RM, Smith WB, Escobar RA, Yueh H, Snyder T, Porco JA, Bradner JE, Beeler AB. Development of a Potent and Selective HDAC8 Inhibitor. Acs Medicinal Chemistry Letters. 7: 929-932. PMID 27774131 DOI: 10.1021/acsmedchemlett.6b00239  0.442
2016 Boyce JH, Eschenbrenner-Lux V, Porco JA. Syntheses of (+)-30-epi-, (-)-6-epi-, (±)-6,30-epi-13,14-Didehydroxyisogarcinol and (±)-6,30-epi-Garcimultiflorone A Utilizing Highly Diastereoselective, Lewis Acid-Controlled Cyclizations. Journal of the American Chemical Society. 138: 14789-14797. PMID 27744695 DOI: 10.1021/jacs.6b09727  0.785
2016 Porco J, Wang W, Cencic R, Whitesell L, Pelletier J. Synthesis of Aza-Rocaglates via ESIPT-Mediated (3+2) Photocycloaddition. Chemistry (Weinheim An Der Bergstrasse, Germany). PMID 27338157 DOI: 10.1002/Chem.201602953  0.729
2016 Qi C, Xiong Y, Eschenbrenner-Lux V, Cong H, Porco JA. Asymmetric Syntheses of the Flavonoid Diels-Alder Natural Products Sanggenons C and O. Journal of the American Chemical Society. PMID 26735066 DOI: 10.1021/Jacs.5B12778  0.607
2016 Hayashi M, Brown LE, Porco JA. Asymmetric Dearomatization/Cyclization Enables Access to Polycyclic Chemotypes European Journal of Organic Chemistry. DOI: 10.1002/ejoc.201601003  0.531
2015 Liu S, Wang W, Brown LE, Qiu C, Lajkiewicz N, Zhao T, Zhou J, Porco JA, Wang TT. A Novel Class of Small Molecule Compounds that Inhibit Hepatitis C Virus Infection by Targeting the Prohibitin-CRaf Pathway. Ebiomedicine. 2: 1600-6. PMID 26870784 DOI: 10.1016/J.Ebiom.2015.09.018  0.772
2015 Chu J, Cencic R, Wang W, Porco JA, Pelletier J. Translation Inhibition by Rocaglates is Independent of eIF4E Phosphorylation Status. Molecular Cancer Therapeutics. PMID 26586722 DOI: 10.1158/1535-7163.Mct-15-0409  0.659
2015 Qin T, Iwata T, Ransom TT, Beutler JA, Porco JA. Syntheses of Dimeric Tetrahydroxanthones with Varied Linkages: Investigation of "Shapeshifting" Properties. Journal of the American Chemical Society. PMID 26544765 DOI: 10.1021/Jacs.5B09825  0.548
2015 Gervais A, Lazarski KE, Porco JA. Divergent Total Syntheses of Rhodomyrtosones A and B. The Journal of Organic Chemistry. 80: 9584-91. PMID 26351970 DOI: 10.1021/Acs.Joc.5B01570  0.594
2015 Yeo AT, Chennamadhavuni S, Whitty A, Porco JA, Gilmore TD. Inhibition of Oncogenic Transcription Factor REL by the Natural Product Derivative Calafianin Monomer 101 Induces Proliferation Arrest and Apoptosis in Human B-Lymphoma Cell Lines. Molecules (Basel, Switzerland). 20: 7474-94. PMID 25915462 DOI: 10.3390/Molecules20057474  0.765
2015 Stone SD, Lajkiewicz NJ, Whitesell L, Hilmy A, Porco JA. Biomimetic kinetic resolution: highly enantio- and diastereoselective transfer hydrogenation of aglain ketones to access flavagline natural products. Journal of the American Chemical Society. 137: 525-30. PMID 25514979 DOI: 10.1021/Ja511728B  0.809
2015 Liu S, Wang W, Brown LE, Qiu C, Lajkiewicz N, Zhao T, Zhou J, Porco JA, Wang TT. A Novel Class of Small Molecule Compounds that Inhibit Hepatitis C Virus Infection by Targeting the Prohibitin-CRaf Pathway Ebiomedicine. DOI: 10.1016/j.ebiom.2015.09.018  0.777
2014 Yeung CS, Ziegler RE, Porco JA, Jacobsen EN. Thiourea-catalyzed enantioselective addition of indoles to pyrones: alkaloid cores with quaternary carbons. Journal of the American Chemical Society. 136: 13614-7. PMID 25213353 DOI: 10.1021/Ja508523G  0.31
2014 Zhu L, Qi J, Chiao CY, Zhang Q, Porco JA, Faller DV, Dai Y. Identification of a novel polyprenylated acylphloroglucinol‑derived SIRT1 inhibitor with cancer‑specific anti-proliferative and invasion-suppressing activities. International Journal of Oncology. 45: 2128-36. PMID 25189993 DOI: 10.3892/Ijo.2014.2639  0.484
2014 Grenning AJ, Boyce JH, Porco JA. Rapid synthesis of polyprenylated acylphloroglucinol analogs via dearomative conjunctive allylic annulation. Journal of the American Chemical Society. 136: 11799-804. PMID 25061804 DOI: 10.1021/ja5060302  0.814
2014 Villar EA, Beglov D, Chennamadhavuni S, Porco JA, Kozakov D, Vajda S, Whitty A. How proteins bind macrocycles. Nature Chemical Biology. 10: 723-31. PMID 25038790 DOI: 10.1038/Nchembio.1584  0.765
2014 Boyce JH, Porco JA. Asymmetric, stereodivergent synthesis of (-)-clusianone utilizing a biomimetic cationic cyclization. Angewandte Chemie (International Ed. in English). 53: 7832-7. PMID 24916169 DOI: 10.1002/anie.201404437  0.801
2014 Lajkiewicz NJ, Cognetta AB, Niphakis MJ, Cravatt BF, Porco JA. Remodeling natural products: chemistry and serine hydrolase activity of a rocaglate-derived β-lactone. Journal of the American Chemical Society. 136: 2659-64. PMID 24447064 DOI: 10.1021/Ja412431G  0.816
2014 Grenning AJ, Snyder JK, Porco JA. Remodeling of fumagillol: discovery of an oxygen-directed oxidative Mannich reaction. Organic Letters. 16: 792-5. PMID 24410175 DOI: 10.1021/Ol4035269  0.729
2014 Grenning AJ, Boyce JH, Porco JA. Rapid synthesis of polyprenylated acylphloroglucinol analogs via dearomative conjunctive allylic annulation Journal of the American Chemical Society. 136: 11799-11804. DOI: 10.1021/ja5060302  0.808
2013 Santagata S, Mendillo ML, Tang YC, Subramanian A, Perley CC, Roche SP, Wong B, Narayan R, Kwon H, Koeva M, Amon A, Golub TR, Porco JA, Whitesell L, Lindquist S. Tight coordination of protein translation and HSF1 activation supports the anabolic malignant state. Science (New York, N.Y.). 341: 1238303. PMID 23869022 DOI: 10.1126/Science.1238303  0.573
2013 Winter DK, Endoma-Arias MA, Hudlicky T, Beutler JA, Porco JA. Enantioselective total synthesis and biological evaluation of (+)-kibdelone A and a tetrahydroxanthone analogue. The Journal of Organic Chemistry. 78: 7617-26. PMID 23834060 DOI: 10.1021/Jo401169Z  0.593
2013 Xiong Y, Schaus SE, Porco JA. Metal-catalyzed cascade rearrangements of 3-alkynyl flavone ethers. Organic Letters. 15: 1962-5. PMID 23574045 DOI: 10.1021/Ol400631B  0.535
2013 Winter DK, Sloman DL, Porco JA. Polycyclic xanthone natural products: structure, biological activity and chemical synthesis. Natural Product Reports. 30: 382-91. PMID 23334431 DOI: 10.1039/c3np20122h  0.765
2012 Dong S, Qin T, Hamel E, Beutler JA, Porco JA. Synthesis of chamaecypanone C analogues from in situ-generated cyclopentadienones and their biological evaluation. Journal of the American Chemical Society. 134: 19782-7. PMID 23110297 DOI: 10.1021/Ja3084708  0.687
2012 Leng B, Chichetti S, Su S, Beeler AB, Porco JA. Synthesis of a novel chemotype via sequential metal-catalyzed cycloisomerizations. Beilstein Journal of Organic Chemistry. 8: 1338-43. PMID 23019468 DOI: 10.3762/Bjoc.8.153  0.51
2012 Ziegler RE, Tan SJ, Kam TS, Porco JA. Development of an alkaloid-pyrone annulation: synthesis of pleiomaltinine. Angewandte Chemie (International Ed. in English). 51: 9348-51. PMID 22893619 DOI: 10.1002/anie.201204093  0.303
2012 Lajkiewicz NJ, Roche SP, Gerard B, Porco JA. Enantioselective photocycloaddition of 3-hydroxyflavones: total syntheses and absolute configuration assignments of (+)-ponapensin and (+)-elliptifoline. Journal of the American Chemical Society. 134: 13108-13. PMID 22804454 DOI: 10.1021/Ja305342F  0.805
2012 Little A, Porco JA. Total syntheses of graphisin A and sydowinin B. Organic Letters. 14: 2862-2865. PMID 22621405 DOI: 10.1021/Ol301107M  0.685
2012 Scully SS, Porco JA. Studies toward the synthesis of the epoxykinamycin FL-120B': discovery of a decarbonylative photocyclization. Organic Letters. 14: 2646-9. PMID 22571279 DOI: 10.1021/Ol3010563  0.588
2012 Zhang Q, Porco JA. Total Synthesis of (±)-7-epi-Nemorosone Organic Letters. 14: 1796-1799. PMID 22449198 DOI: 10.1021/Ol300386T  0.382
2012 Achard M, Beeler AB, Porco JA. Synthesis of azaphilone-based chemical libraries Acs Combinatorial Science. 14: 236-244. PMID 22330196 DOI: 10.1021/Co300002X  0.312
2012 Rodrigo CM, Cencic R, Roche SP, Pelletier J, Porco JA. Synthesis of rocaglamide hydroxamates and related compounds as eukaryotic translation inhibitors: synthetic and biological studies. Journal of Medicinal Chemistry. 55: 558-62. PMID 22128783 DOI: 10.1021/Jm201263K  0.679
2011 Scully SS, Porco JA. Asymmetric total synthesis of the epoxykinamycin FL-120 B'. Angewandte Chemie (International Ed. in English). 50: 9722-6. PMID 21953671 DOI: 10.1002/Anie.201104504  0.615
2011 Dong S, Cahill KJ, Kang MI, Colburn NH, Henrich CJ, Wilson JA, Beutler JA, Johnson RP, Porco JA. Microwave-based reaction screening: tandem retro-Diels-Alder/Diels-Alder cycloadditions of o-quinol dimers. The Journal of Organic Chemistry. 76: 8944-54. PMID 21942286 DOI: 10.1021/Jo201658Y  0.64
2011 Ebada SS, Lajkiewicz N, Porco JA, Li-Weber M, Proksch P. Chemistry and biology of rocaglamides (= flavaglines) and related derivatives from aglaia species (meliaceae). Progress in the Chemistry of Organic Natural Products. 94: 1-58. PMID 21833837 DOI: 10.1007/978-3-7091-0748-5_1  0.758
2011 Brown LE, Dai P, Porco JA, Schaus SE. Gold catalyzed cyclization of alkyne-tethered dihydropyrimidones. Organic Letters. 13: 4228-31. PMID 21749159 DOI: 10.1021/Ol2015658  0.55
2011 Medeiros MR, Schaus SE, Porco JA. A cycloisomerization/Friedel-Crafts alkylation strategy for the synthesis of pyrano[3,4-b]indoles. Organic Letters. 13: 4012-5. PMID 21740020 DOI: 10.1021/Ol201532K  0.331
2011 Sloman DL, Bacon JW, Porco JA. Total synthesis and absolute stereochemical assignment of kibdelone C. Journal of the American Chemical Society. 133: 9952-5. PMID 21648477 DOI: 10.1021/Ja203642N  0.786
2011 Wu J, Becerril J, Lian Y, Davies HM, Porco JA, Panek JS. Sequential transformations to access polycyclic chemotypes: asymmetric crotylation and metal carbenoid reactions. Angewandte Chemie (International Ed. in English). 50: 5938-42. PMID 21560214 DOI: 10.1002/Anie.201101366  0.431
2011 Roche SP, Porco JA. Dearomatization strategies in the synthesis of complex natural products. Angewandte Chemie (International Ed. in English). 50: 4068-93. PMID 21506209 DOI: 10.1002/anie.201006017  0.657
2011 Brown LE, Chih-Chien Cheng K, Wei WG, Yuan P, Dai P, Trilles R, Ni F, Yuan J, MacArthur R, Guha R, Johnson RL, Su XZ, Dominguez MM, Snyder JK, Beeler AB, ... ... Porco JA, et al. Discovery of new antimalarial chemotypes through chemical methodology and library development. Proceedings of the National Academy of Sciences of the United States of America. 108: 6775-80. PMID 21498685 DOI: 10.1073/Pnas.1017666108  0.494
2011 Germain AR, Bruggemeyer DM, Zhu J, Genet C, O'Brien P, Porco JA. Synthesis of the azaphilones (+)-sclerotiorin and (+)-8-O-methylsclerotiorinamine utilizing (+)-sparteine surrogates in copper-mediated oxidative dearomatization. The Journal of Organic Chemistry. 76: 2577-84. PMID 21401026 DOI: 10.1021/Jo102448N  0.662
2011 Sloman DL, Mitasev B, Scully SS, Beutler JA, Porco JA. Synthesis and biological evaluation of ABCD ring fragments of the kibdelones. Angewandte Chemie (International Ed. in English). 50: 2511-5. PMID 21370327 DOI: 10.1002/Anie.201007613  0.778
2011 Xia B, Gerard B, Solano DM, Wan J, Jones G, Porco JA. ESIPT-mediated photocycloadditions of 3-hydroxyquinolinones: development of a fluorescence quenching assay for reaction screening. Organic Letters. 13: 1346-9. PMID 21338078 DOI: 10.1021/Ol200032F  0.506
2010 Zhang Q, Mitasev B, Qi J, Porco JA. Total synthesis of plukenetione A. Journal of the American Chemical Society. 132: 14212-5. PMID 20843036 DOI: 10.1021/Ja105784S  0.789
2010 Qi J, Beeler AB, Zhang Q, Porco JA. Catalytic enantioselective alkylative dearomatization-annulation: total synthesis and absolute configuration assignment of hyperibone K. Journal of the American Chemical Society. 132: 13642-4. PMID 20831187 DOI: 10.1021/Ja1057828  0.504
2010 Roche SP, Cencic R, Pelletier J, Porco JA. Biomimetic photocycloaddition of 3-hydroxyflavones: synthesis and evaluation of rocaglate derivatives as inhibitors of eukaryotic translation. Angewandte Chemie (International Ed. in English). 49: 6533-8. PMID 20687060 DOI: 10.1002/Anie.201003212  0.631
2010 Marié JC, Xiong Y, Min GK, Yeager AR, Taniguchi T, Berova N, Schaus SE, Porco JA. Enantioselective synthesis of 3,4-chromanediones via asymmetric rearrangement of 3-allyloxyflavones. The Journal of Organic Chemistry. 75: 4584-90. PMID 20527786 DOI: 10.1021/Jo100889C  0.591
2009 Mitasev B, Porco JA. Manganese(III)-mediated transformations of phloroglucinols: a formal oxidative [4 + 2] cycloaddition leading to bicyclo[2.2.2]octadiones. Organic Letters. 11: 2285-8. PMID 19415907 DOI: 10.1021/ol900590t  0.733
2009 Dong S, Hamel E, Bai R, Covell DG, Beutler JA, Porco JA. Enantioselective synthesis of (+)-chamaecypanone C: a novel microtubule inhibitor. Angewandte Chemie (International Ed. in English). 48: 1494-7. PMID 19140149 DOI: 10.1002/Anie.200805486  0.682
2009 Han C, Rangarajan S, Voukides AC, Beeler AB, Johnson R, Porco JA. Reaction discovery employing macrocycles: transannular cyclizations of macrocyclic bis-lactams. Organic Letters. 11: 413-6. PMID 19102683 DOI: 10.1021/Ol802729F  0.563
2009 Dong S, Hamel E, Bai R, Covell DG, Beutler JA, Porco JA. Synthesis of (+)-Chamaecypanone C Synfacts. 2009: 829-829. DOI: 10.1055/S-0029-1217508  0.551
2008 Bordeleau ME, Robert F, Gerard B, Lindqvist L, Chen SM, Wendel HG, Brem B, Greger H, Lowe SW, Porco JA, Pelletier J. Therapeutic suppression of translation initiation modulates chemosensitivity in a mouse lymphoma model. The Journal of Clinical Investigation. 118: 2651-60. PMID 18551192 DOI: 10.1172/Jci34753  0.563
2008 Dong S, Zhu J, Porco JA. Enantioselective synthesis of bicyclo[2.2.2]octenones using a copper-mediated oxidative dearomatization/[4 + 2] dimerization cascade. Journal of the American Chemical Society. 130: 2738-9. PMID 18266375 DOI: 10.1021/Ja711018Z  0.658
2008 Porco JA, Gerard B. Chapter 6 A biomimetic approach to the rocaglamides employing photogeneration of oxidopyryliums derived from 3-hydroxyflavones Strategies and Tactics in Organic Synthesis. 7. DOI: 10.1016/S1874-6004(08)80010-X  0.532
2007 Su S, Porco JA. 1,2-dihydroisoquinolines as templates for cascade reactions to access isoquinoline alkaloid frameworks. Organic Letters. 9: 4983-6. PMID 17958365 DOI: 10.1021/Ol702176H  0.513
2007 Qi J, Porco JA. Rapid access to polyprenylated phloroglucinols via alkylative dearomatization-annulation: total synthesis of (+/-)-clusianone(1). Journal of the American Chemical Society. 129: 12682-3. PMID 17902679 DOI: 10.1021/Ja0762339  0.506
2007 Gerard B, Cencic R, Pelletier J, Porco JA. Enantioselective synthesis of the complex rocaglate (-)-silvestrol. Angewandte Chemie (International Ed. in English). 46: 7831-4. PMID 17806093 DOI: 10.1002/Anie.200702707  0.591
2007 Peng LF, Kim SS, Matchacheep S, Lei X, Su S, Lin W, Runguphan W, Choe WH, Sakamoto N, Ikeda M, Kato N, Beeler AB, Porco JA, Schreiber SL, Chung RT. Identification of novel epoxide inhibitors of hepatitis C virus replication using a high-throughput screen. Antimicrobial Agents and Chemotherapy. 51: 3756-9. PMID 17682098 DOI: 10.1128/Aac.00233-07  0.758
2007 Su S, Porco JA. Synthesis of pyrrolo-isoquinolines related to the lamellarins using silver-catalyzed cycloisomerization/dipolar cycloaddition. Journal of the American Chemical Society. 129: 7744-5. PMID 17539647 DOI: 10.1021/Ja072737V  0.561
2007 Han C, Porco JA. Synthesis of carbamates and ureas using Zr(IV)-catalyzed exchange processes. Organic Letters. 9: 1517-20. PMID 17358074 DOI: 10.1021/ol0702728  0.507
2007 Beeler AB, Su S, Singleton CA, Porco JA. Discovery of chemical reactions through multidimensional screening. Journal of the American Chemical Society. 129: 1413-9. PMID 17263426 DOI: 10.1021/Ja0674744  0.479
2007 Zhou Y, Porco JA, Snyder JK. Synthesis of 5,6,7,8-tetrahydro-1,6-naphthyridines and related heterocycles by cobalt-catalyzed [2 + 2 + 2] cyclizations. Organic Letters. 9: 393-6. PMID 17249770 DOI: 10.1021/Ol0625280  0.342
2006 Lei X, Porco JA. Total synthesis of the diazobenzofluorene antibiotic (-)-kinamycin C1. Journal of the American Chemical Society. 128: 14790-1. PMID 17105273 DOI: 10.1021/Ja066621V  0.553
2006 Zhu J, Porco JA. Asymmetric syntheses of (-)-mitorubrin and related azaphilone natural products. Organic Letters. 8: 5169-71. PMID 17048870 DOI: 10.1021/Ol062233M  0.531
2006 Porco JA, Su S, Lei X, Bardhan S, Rychnovsky SD. Total synthesis and structure assignment of (+)-hexacyclinol. Angewandte Chemie (International Ed. in English). 45: 5790-2. PMID 16871643 DOI: 10.1002/Anie.200602854  0.785
2006 Kleinke AS, Li C, Rabasso N, Porco JA. Total synthesis of the interleukin-1beta converting enzyme inhibitor EI-1941-2 using tandem oxa-electrocyclization/oxidation1. Organic Letters. 8: 2847-50. PMID 16774272 DOI: 10.1021/Ol060954F  0.774
2006 Gerard B, Sangji S, O'Leary DJ, Porco JA. Enantioselective photocycloaddition mediated by chiral Brønsted acids: asymmetric synthesis of the rocaglamides. Journal of the American Chemical Society. 128: 7754-5. PMID 16771486 DOI: 10.1021/Ja062621J  0.616
2006 Zhang CY, Parton LE, Ye CP, Krauss S, Shen R, Lin CT, Porco JA, Lowell BB. Genipin inhibits UCP2-mediated proton leak and acutely reverses obesity- and high glucose-induced beta cell dysfunction in isolated pancreatic islets. Cell Metabolism. 3: 417-27. PMID 16753577 DOI: 10.1016/J.Cmet.2006.04.010  0.489
2006 Bardhan S, Schmitt DC, Porco JA. Total synthesis and stereochemical assignment of the spiroisoxazoline natural product (+)-calafianin. Organic Letters. 8: 927-30. PMID 16494476 DOI: 10.1021/Ol053115M  0.656
2006 Liang MC, Bardhan S, Pace EA, Rosman D, Beutler JA, Porco JA, Gilmore TD. Inhibition of transcription factor NF-kappaB signaling proteins IKKbeta and p65 through specific cysteine residues by epoxyquinone A monomer: correlation with its anti-cancer cell growth activity. Biochemical Pharmacology. 71: 634-45. PMID 16360644 DOI: 10.1016/J.Bcp.2005.11.013  0.677
2006 Liang MC, Bardhan S, Porco JA, Gilmore TD. The synthetic epoxyquinoids jesterone dimer and epoxyquinone A monomer induce apoptosis and inhibit REL (human c-Rel) DNA binding in an IkappaBalpha-deficient diffuse large B-cell lymphoma cell line. Cancer Letters. 241: 69-78. PMID 16289774 DOI: 10.1016/J.Canlet.2005.10.004  0.557
2006 Gerard B, Ryan J, Beeler AB, Porco JA. Synthesis of 1,4,5-trisubstituted-1,2,3-triazoles by copper-catalyzed cycloaddition-coupling of azides and terminal alkynes Tetrahedron. 62: 6405-6411. DOI: 10.1016/J.Tet.2006.04.025  0.551
2005 Lei X, Zaarur N, Sherman MY, Porco JA. Stereocontrolled synthesis of a complex library via elaboration of angular epoxyquinol scaffolds. The Journal of Organic Chemistry. 70: 6474-83. PMID 16050712 DOI: 10.1021/Jo050956Y  0.564
2005 Li C, Porco JA. Synthesis of epoxyquinol A and related molecules: probing chemical reactivity of epoxyquinol dimers and 2H-pyran precursors. The Journal of Organic Chemistry. 70: 6053-65. PMID 16018703 DOI: 10.1021/Jo050897O  0.672
2005 Han C, Lee JP, Lobkovsky E, Porco JA. Catalytic ester-amide exchange using group (IV) metal alkoxide-activator complexes. Journal of the American Chemical Society. 127: 10039-44. PMID 16011366 DOI: 10.1021/Ja0527976  0.486
2005 Zhu J, Grigoriadis NP, Lee JP, Porco JA. Synthesis of the azaphilones using copper-mediated enantioselective oxidative dearomatization. Journal of the American Chemical Society. 127: 9342-3. PMID 15984841 DOI: 10.1021/Ja052049G  0.514
2005 Su S, Acquilano DE, Arumugasamy J, Beeler AB, Eastwood EL, Giguere JR, Lan P, Lei X, Min GK, Yeager AR, Zhou Y, Panek JS, Snyder JK, Schaus SE, Porco JA. Convergent synthesis of a complex oxime library using chemical domain shuffling. Organic Letters. 7: 2751-4. PMID 15957938 DOI: 10.1021/Ol051023R  0.647
2005 Shen R, Inoue T, Forgac M, Porco JA. Synthesis of photoactivatable acyclic analogues of the lobatamides. The Journal of Organic Chemistry. 70: 3686-92. PMID 15845008 DOI: 10.1021/Jo0477751  0.566
2005 Wang X, Porco JA. Synthesis of the Tetracyclic Core of the Tetrapetalones through Transannular Oxidative [4+3] Cyclization Angewandte Chemie. 44: 3067-3071. PMID 15832389 DOI: 10.1002/Anie.200500247  0.457
2005 Porco J, Zhu J, Grigoriadis N, Lee J. Copper-Mediated Synthesis of Azaphilones Synfacts. 2006: 0001-0001. DOI: 10.1055/s-2005-921655  0.488
2005 Gerard B, Jones aG, Porco JA. A Biomimetic Approach to the Rocaglamides Employing Photogeneration of Oxidopyryliums Derived from 3-Hydroxyflavones [J. Am. Chem. Soc. 2004, 126, 13620−13621]. Journal of the American Chemical Society. 127: 1334-1334. DOI: 10.1021/Ja042481I  0.519
2004 Gerard B, Jones Ii G, Porco JA. A biomimetic approach to the rocaglamides employing photogeneration of oxidopyryliums derived from 3-hydroxyflavones. Journal of the American Chemical Society. 126: 13620-1. PMID 15493911 DOI: 10.1021/Ja044798O  0.581
2004 Wang X, Bowman EJ, Bowman BJ, Porco JA. Total synthesis of the salicylate enamide macrolide oximidine III: application of relay ring-closing metathesis. Angewandte Chemie (International Ed. in English). 43: 3601-5. PMID 15293258 DOI: 10.1002/Anie.200460042  0.462
2004 Zhu J, Germain AR, Porco JA. Synthesis of azaphilones and related molecules by employing cycloisomerization of o-alkynylbenzaldehydes. Angewandte Chemie (International Ed. in English). 43: 1239-43. PMID 14991787 DOI: 10.1002/Anie.200353037  0.648
2004 Lei X, Porco JA. Synthesis of a polymer-supported anthracene and its application as a dienophile scavenger. Organic Letters. 6: 795-8. PMID 14986977 DOI: 10.1021/Ol036502+  0.448
2004 Li C, Porco JA. Synthesis of the epoxyquinol dimer RKB-3564 D: utilization of an alkoxysilanol to promote [4 + 4] dimerization. Journal of the American Chemical Society. 126: 1310-1. PMID 14759167 DOI: 10.1021/Ja039543+  0.666
2004 Han C, Shen R, Su S, Porco JA. Copper-mediated synthesis of N-acyl vinylogous carbamic acids and derivatives: synthesis of the antibiotic CJ-15,801. Organic Letters. 6: 27-30. PMID 14703342 DOI: 10.1021/Ol0360041  0.728
2004 Su S, Giguere JR, Schaus SE, Porco JA. Synthesis of complex alkoxyamines using a polymer-supported N-hydroxyphthalimide Tetrahedron. 60: 8645-8657. DOI: 10.1016/J.Tet.2004.05.109  0.47
2003 Lei X, Johnson RP, Porco JA. Total synthesis of the ubiquitin-activating enzyme inhibitor (+)-panepophenanthrin. Angewandte Chemie (International Ed. in English). 42: 3913-7. PMID 12949867 DOI: 10.1002/Anie.200351862  0.509
2003 Shen R, Lin CT, Bowman EJ, Bowman BJ, Porco JA. Lobatamide C: total synthesis, stereochemical assignment, preparation of simplified analogues, and V-ATPase inhibition studies. Journal of the American Chemical Society. 125: 7889-901. PMID 12823009 DOI: 10.1021/Ja0352350  0.595
2003 Liang MC, Bardhan S, Li C, Pace EA, Porco JA, Gilmore TD. Jesterone dimer, a synthetic derivative of the fungal metabolite jesterone, blocks activation of transcription factor nuclear factor kappaB by inhibiting the inhibitor of kappaB kinase. Molecular Pharmacology. 64: 123-31. PMID 12815168 DOI: 10.1124/Mol.64.1.123  0.749
2003 Wang X, Porco JA. Total synthesis of the salicylate enamide macrolide oximidine II. Journal of the American Chemical Society. 125: 6040-6041. PMID 12785818 DOI: 10.1021/Ja034030O  0.492
2003 Li C, Johnson RP, Porco JA. Total synthesis of the quinone epoxide dimer (+)-torreyanic acid: application of a biomimetic oxidation/electrocyclization/Diels-Alder dimerization cascade. Journal of the American Chemical Society. 125: 5095-106. PMID 12708860 DOI: 10.1021/Ja021396C  0.711
2003 Su S, Kakeya H, Osada H, Porco JA. Synthesis and cell cycle inhibition of the peptide enamide natural products terpeptin and the aspergillamides Tetrahedron. 59: 8931-8946. DOI: 10.1016/J.Tet.2003.04.005  0.575
2002 Li C, Bardhan S, Pace EA, Liang MC, Gilmore TD, Porco JA. Angiogenesis inhibitor epoxyquinol a: total synthesis and inhibition of transcription factor NF-kappaB. Organic Letters. 4: 3267-70. PMID 12227765 DOI: 10.1021/Ol026513N  0.773
2002 Shen R, Lin CT, Bowman EJ, Bowman BJ, Porco JA. Synthesis and V-ATPase inhibition of simplified lobatamide analogues. Organic Letters. 4: 3103-6. PMID 12201727 DOI: 10.1021/Ol026391Z  0.566
2002 Shen R, Lin CT, Porco JA. Total synthesis and stereochemical assignment of the salicylate antitumor macrolide lobatamide C(1). Journal of the American Chemical Society. 124: 5650-1. PMID 12010033 DOI: 10.1021/Ja026025A  0.598
2002 Kulkarni BA, Roth GP, Lobkovsky E, Porco JA. Combinatorial synthesis of natural product-like molecules using a first-generation spiroketal scaffold. Journal of Combinatorial Chemistry. 4: 56-72. PMID 11831883 DOI: 10.1021/CC010047W  0.324
2002 Li C, Bardhan S, Pace EA, Liang MC, Gilmore TD, Porco JA. Angiogenesis inhibitor epoxyquinol A: Total synthesis and inhibition of transcription factor NF-κB Organic Letters. 4: 3267-3270. DOI: 10.1021/ol026513n  0.748
2001 Wang X, Porco JA. Modification of C-terminal peptides to form peptide enamides: synthesis of chondriamides A and C. Journal of Organic Chemistry. 66: 8215-8221. PMID 11722228 DOI: 10.1021/Jo0158027  0.374
2001 Li C, Pace EA, Liang MC, Lobkovsky E, Gilmore TD, Porco JA. Total synthesis of the NF-kappa B inhibitor (-)-cycloepoxydon: utilization of tartrate-mediated nucleophilic epoxidation. Journal of the American Chemical Society. 123: 11308-9. PMID 11697981 DOI: 10.1021/Ja0169769  0.69
2001 Hu Y, Li C, Kulkarni BA, Strobel G, Lobkovsky E, Torczynski RM, Porco JA. Exploring chemical diversity of epoxyquinoid natural products: synthesis and biological activity of (-)-jesterone and related molecules. Organic Letters. 3: 1649-1652. PMID 11405677 DOI: 10.1021/Ol0159367  0.738
2000 Wang X, Parlow JJ, Porco JA. Parallel Synthesis and Purification Using Anthracene-Tagged Substrates Organic Letters. 2: 3509-3512. PMID 11082021 DOI: 10.1021/Ol0065625  0.461
1995 Wong C, Provencher L, Porco JA, Jung S, Wang Y, Chen L, Wang R, Steensma DH. Synthesis and Evaluation of Homoaza Sugars as Glycosidase Inhibitors Journal of Organic Chemistry. 60: 1492-1501. DOI: 10.1021/Jo00111A007  0.438
1988 Schreiber SL, Desmaele D, Porco JA. On the use of unsymmetrically substituted furans in the furan-carbonyl photocycloaddition reaction: Synthesis of a kadsurenone-ginkgolide hybrid Tetrahedron Letters. 29: 6689-6692. DOI: 10.1016/S0040-4039(00)82429-6  0.699
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