| Year |
Citation |
Score |
| 2025 |
Goldstein SI, Fan AC, Wang Z, Naineni SK, Cencic R, Garcia-Gutierrez SB, Patel K, Huang S, Brown LE, Emili A, Porco JA. Discovery of RNA-Protein Molecular Clamps Using Proteome-Wide Stability Assays. Journal of Proteome Research. PMID 40077831 DOI: 10.1021/acs.jproteome.4c01129 |
0.467 |
|
| 2025 |
Conley JF, Brown LE, McNeely JH, Pelletier J, Porco JA, Allen KN. Structural Basis for the Improved RNA Clamping of Amidino-Rocaglates to eIF4A1. Acs Omega. 10: 5795-5808. PMID 39989799 DOI: 10.1021/acsomega.4c09421 |
0.457 |
|
| 2025 |
Oo A, Borge A, Lee RCH, Salim CK, Wang W, Ricca M, Fong DY, Alonso S, Brown LE, Porco JA, Chu JJH. In Vitro Discovery of a Therapeutic Lead for HFMD From a Library Screen of Rocaglates/Aglains. Journal of Medical Virology. 97: e70228. PMID 39921602 DOI: 10.1002/jmv.70228 |
0.66 |
|
| 2024 |
Avancha A, Hoyt H, Bhave K, Medeiros M, Cho D, Brown LE, Fernández González D, Porco JA, Forman SA. Glabridin Hypnosis in Zebrafish Larvae Is Associated With Effects on Multiple Anesthetic Target Receptors. Anesthesia and Analgesia. PMID 39773742 DOI: 10.1213/ANE.0000000000007318 |
0.393 |
|
| 2024 |
Wang Z, Thakare RP, Chitale S, Mishra AK, Goldstein SI, Fan AC, Li R, Zhu LJ, Brown LE, Cencic R, Huang S, Green MR, Pelletier J, Malonia SK, Porco JA. Identification of Rocaglate Acyl Sulfamides as Selective Inhibitors of Glioblastoma Stem Cells. Acs Central Science. 10: 1640-1656. PMID 39220711 DOI: 10.1021/acscentsci.4c01073 |
0.464 |
|
| 2024 |
Yang F, Oladokun A, Porco JA. Evolution of a Strategy for the Unified, Asymmetric Total Syntheses of DMOA-Derived Spiromeroterpenoids. The Journal of Organic Chemistry. PMID 39133739 DOI: 10.1021/acs.joc.4c01116 |
0.321 |
|
| 2024 |
Keiser PT, Zhang W, Ricca M, Wacquiez A, Grimins A, Cencic R, Patten JJ, Shah P, Padilha E, Connor JH, Pelletier J, Lyons SM, Saeed M, Brown LE, Porco JA, et al. Amidino-Rocaglates (ADRs), a class of synthetic rocaglates, are potent inhibitors of SARS-CoV-2 replication through inhibition of viral protein synthesis. Antiviral Research. 105976. PMID 39117283 DOI: 10.1016/j.antiviral.2024.105976 |
0.531 |
|
| 2024 |
Thirman HL, Hayes MJ, Brown LE, Porco JA, Irish JM. Single Cell Profiling Distinguishes Leukemia-Selective Chemotypes. Biorxiv : the Preprint Server For Biology. PMID 38826485 DOI: 10.1101/2024.05.01.591362 |
0.458 |
|
| 2024 |
Volegova MP, Brown LE, Banerjee U, Dries R, Sharma B, Kennedy A, Porco JA, George RE. The MYCN 5' UTR as a therapeutic target in neuroblastoma. Cell Reports. 43: 114134. PMID 38662542 DOI: 10.1016/j.celrep.2024.114134 |
0.49 |
|
| 2024 |
Goldstein SI, Fan AC, Wang Z, Naineni SK, Lengqvist J, Chernobrovkin A, Garcia-Gutierrez SB, Cencic R, Patel K, Huang S, Brown LE, Emili A, Porco JA. Proteomic Discovery of RNA-Protein Molecular Clamps Using a Thermal Shift Assay with ATP and RNA (TSAR). Biorxiv : the Preprint Server For Biology. PMID 38659867 DOI: 10.1101/2024.04.19.590252 |
0.454 |
|
| 2024 |
Fallah S, Duncan D, Reichl KD, Smith MJ, Wang W, Porco JA, Brown LE, Whitesell L, Robbins N, Cowen LE. A chemical screen identifies structurally diverse metal chelators with activity against the fungal pathogen . Microbiology Spectrum. e0409523. PMID 38376363 DOI: 10.1128/spectrum.04095-23 |
0.677 |
|
| 2024 |
Ji K, Johnson RP, McNeely J, Al Faruk M, Porco JA. Asymmetric Synthesis of Nidulalin A and Nidulaxanthone A: Selective Carbonyl Desaturation Using an Oxoammonium Salt. Journal of the American Chemical Society. PMID 38319883 DOI: 10.1021/jacs.3c13864 |
0.342 |
|
| 2023 |
Millimaci AM, Trilles RV, McNeely JH, Brown LE, Beeler AB, Porco JA. Synthesis of Neocannabinoids Using Controlled Friedel-Crafts Reactions. The Journal of Organic Chemistry. PMID 37657122 DOI: 10.1021/acs.joc.3c01362 |
0.503 |
|
| 2023 |
Naineni SK, Cencic R, Robert F, Brown L, Haque M, Scott-Talib J, Senechal P, Schmeing TM, Porco J, Pelletier J. Exploring the Targeting Spectrum of Rocaglates Among eIF4A Homologs. Rna (New York, N.Y.). PMID 36882295 DOI: 10.1261/rna.079318.122 |
0.459 |
|
| 2022 |
Shaashua L, Ben-Shmuel A, Pevsner-Fischer M, Friedman G, Levi-Galibov O, Nandakumar S, Barki D, Nevo R, Brown LE, Zhang W, Stein Y, Lior C, Kim HS, Bojmar L, Jarnagin WR, ... ... Porco JA, et al. BRCA mutational status shapes the stromal microenvironment of pancreatic cancer linking clusterin expression in cancer associated fibroblasts with HSF1 signaling. Nature Communications. 13: 6513. PMID 36316305 DOI: 10.1038/s41467-022-34081-3 |
0.395 |
|
| 2022 |
Yang F, Porco JA. Unified, Asymmetric Total Synthesis of the Asnovolins and Related Spiromeroterpenoids: A Fragment Coupling Approach. Journal of the American Chemical Society. PMID 35792599 DOI: 10.1021/jacs.2c05366 |
0.306 |
|
| 2022 |
Lehman SL, Wechsler T, Schwartz K, Brown LE, Porco JA, Devine WG, Pelletier J, Shankavaram UT, Camphausen K, Tofilon PJ. Inhibition of the translation initiation factor eIF4A enhances tumor cell radiosensitivity. Molecular Cancer Therapeutics. PMID 35732578 DOI: 10.1158/1535-7163.MCT-22-0037 |
0.462 |
|
| 2022 |
Praditya DF, Klöhn M, Brüggemann Y, Brown LE, Porco JA, Zhang W, Kinast V, Kirschning A, Vondran FWR, Todt D, Steinmann E. Identification of structurally re-engineered rocaglates as inhibitors against hepatitis E virus replication. Antiviral Research. 105359. PMID 35728703 DOI: 10.1016/j.antiviral.2022.105359 |
0.491 |
|
| 2021 |
Xu W, Brown LE, Porco JA. Divergent, C-C Bond Forming Macrocyclizations Using Modular Sulfonylhydrazone and Derived Substrates. The Journal of Organic Chemistry. PMID 34730970 DOI: 10.1021/acs.joc.1c01848 |
0.558 |
|
| 2021 |
Chatterjee S, Yabaji SM, Rukhlenko OS, Bhattacharya B, Waligurski E, Vallavoju N, Ray S, Kholodenko BN, Brown LE, Beeler AB, Ivanov AR, Kobzik L, Porco JA, Kramnik I. Channeling macrophage polarization by rocaglates increases macrophage resistance to . Iscience. 24: 102845. PMID 34381970 DOI: 10.1016/j.isci.2021.102845 |
0.4 |
|
| 2020 |
Iyer KR, Camara K, Daniel-Ivad M, Trilles R, Pimentel-Elardo SM, Fossen JL, Marchillo K, Liu Z, Singh S, Muñoz JF, Kim SH, Porco JA, Cuomo CA, Williams NS, Ibrahim AS, et al. An oxindole efflux inhibitor potentiates azoles and impairs virulence in the fungal pathogen Candida auris. Nature Communications. 11: 6429. PMID 33353950 DOI: 10.1038/s41467-020-20183-3 |
0.447 |
|
| 2020 |
Levi-Galibov O, Lavon H, Wassermann-Dozorets R, Pevsner-Fischer M, Mayer S, Wershof E, Stein Y, Brown LE, Zhang W, Friedman G, Nevo R, Golani O, Katz LH, Yaeger R, Laish I, ... Porco JA, et al. Heat Shock Factor 1-dependent extracellular matrix remodeling mediates the transition from chronic intestinal inflammation to colon cancer. Nature Communications. 11: 6245. PMID 33288768 DOI: 10.1038/s41467-020-20054-x |
0.406 |
|
| 2020 |
Boyce JH, Reisman BJ, Bachmann BO, Porco JA. Synthesis and Multiplexed Activity Profiling of Synthetic Acylphloroglucinol Scaffolds. Angewandte Chemie (International Ed. in English). PMID 32965753 DOI: 10.1002/anie.202010338 |
0.798 |
|
| 2020 |
Iyer KR, Whitesell L, Porco JA, Henkel T, Brown LE, Robbins N, Cowen LE. Translation Inhibition by Rocaglates Activates a Species-Specific Cell Death Program in the Emerging Fungal Pathogen Candida auris. Mbio. 11. PMID 32156828 DOI: 10.1128/Mbio.03329-19 |
0.493 |
|
| 2020 |
Chu J, Zhang W, Cencic R, O'Connor PBF, Robert F, Devine WG, Selznick A, Henkel T, Merrick WC, Brown LE, Baranov PV, Porco JA, Pelletier J. Rocaglates Induce Gain-of-Function Alterations to eIF4A and eIF4F. Cell Reports. PMID 32101697 DOI: 10.1016/J.Celrep.2020.02.002 |
0.464 |
|
| 2020 |
Lehman SL, Wechsler T, Schwartz KR, Wahba A, Brown LE, Porco JA, Pelletier J, Camphausen K, Tofilon PJ. Abstract 6507: Inhibition of the translation initiation factor eIF4A1 enhances tumor cell radiosensitivity Cancer Research. 80: 6507-6507. DOI: 10.1158/1538-7445.Am2020-6507 |
0.466 |
|
| 2019 |
Chan K, Robert F, Oertlin C, Kapeller-Libermann D, Avizonis D, Gutierrez J, Handly-Santana A, Doubrovin M, Park J, Schoepfer C, Da Silva B, Yao M, Gorton F, Shi J, Thomas CJ, ... ... Porco JA, et al. eIF4A supports an oncogenic translation program in pancreatic ductal adenocarcinoma. Nature Communications. 10: 5151. PMID 31723131 DOI: 10.1038/S41467-019-13086-5 |
0.453 |
|
| 2019 |
Chu J, Zhang W, Cencic R, Devine WG, Beglov D, Henkel T, Brown LE, Vajda S, Porco JA, Pelletier J. Amidino-Rocaglates: A Potent Class of eIF4A Inhibitors. Cell Chemical Biology. PMID 31519508 DOI: 10.1016/J.Chembiol.2019.08.008 |
0.492 |
|
| 2019 |
Porco J, Powers Z, Scharf A, Cheng A, Yang F, Himmelbauer M, Mitsuhashi T, Barra L, Taniguchi Y, Kikuchi T, Fujita M, Abe I. Biomimetic Synthesis of Meroterpenoids by Dearomatization- Driven Polycyclization. Angewandte Chemie (International Ed. in English). PMID 31515901 DOI: 10.1002/Anie.201910710 |
0.311 |
|
| 2019 |
Zhang W, Chu J, Cyr AM, Yueh H, Brown LE, Wang TT, Pelletier J, Porco JA. Intercepted Retro-Nazarov Reaction: Syntheses of Amidino-Rocaglate Derivatives and Their Biological Evaluation as eIF4A Inhibitors. Journal of the American Chemical Society. PMID 31310112 DOI: 10.1021/Jacs.9B06446 |
0.575 |
|
| 2019 |
Wen S, Boyce JH, Kandappa SK, Sivaguru J, Porco JA. Regiodivergent Photocyclization of Dearomatized Acylphloroglucinols: Asymmetric Syntheses of (-)-Nemorosone and (-)-6- epi-Garcimultiflorone A. Journal of the American Chemical Society. PMID 31264859 DOI: 10.1021/Jacs.9B05600 |
0.777 |
|
| 2019 |
Zhang X, Bi C, Lu T, Zhang W, Yue T, Wang C, Tian T, Zhang X, Huang Y, Lunning M, Hao X, Brown LE, Devine WG, Vose J, Porco JA, et al. Targeting translation initiation by synthetic rocaglates for treating MYC-driven lymphomas. Leukemia. PMID 31171817 DOI: 10.1038/S41375-019-0503-Z |
0.506 |
|
| 2019 |
Chen CD, Zeldich E, Khodr C, Camara K, Tung TY, Lauder EC, Mullen P, Polanco TJ, Liu YY, Zeldich D, Xia W, Van Nostrand WE, Brown LE, Porco JA, Abraham CR. Small Molecule Amyloid-β Protein Precursor Processing Modulators Lower Amyloid-β Peptide Levels via cKit Signaling. Journal of Alzheimer's Disease : Jad. 67: 1089-1106. PMID 30776010 DOI: 10.3233/Jad-180923 |
0.439 |
|
| 2019 |
Itoua Maïga R, Cencic R, Chu J, Waller DD, Brown LE, Devine WG, Zhang W, Sebag M, Porco JA, Pelletier J. Oxo-aglaiastatin-Mediated Inhibition of Translation Initiation. Scientific Reports. 9: 1265. PMID 30718665 DOI: 10.1038/S41598-018-37666-5 |
0.523 |
|
| 2019 |
Porco J, Qin XJ, Rauwolf T, Li PP, Li H, McNeely J, Hua Y, Liu HY. Isolation and Synthesis of Novel Meroterpenoids from Rhodomyrtus tomentosa: Investigation of a Reactive Enetrione Intermediate. Angewandte Chemie (International Ed. in English). PMID 30681258 DOI: 10.1002/anie.201814421 |
0.311 |
|
| 2019 |
Whitesell L, Robbins N, Huang DS, McLellan CA, Shekhar-Guturja T, LeBlanc EV, Nation CS, Hui R, Hutchinson A, Collins C, Chatterjee S, Trilles R, Xie JL, Krysan DJ, Lindquist S, ... Porco JA, et al. Structural basis for species-selective targeting of Hsp90 in a pathogenic fungus. Nature Communications. 10: 402. PMID 30679438 DOI: 10.1038/s41467-018-08248-w |
0.459 |
|
| 2019 |
Trilles R, Beglov D, Chen Q, He H, Wireman R, Reed A, Chennamadhavuni S, Panek JS, Brown LE, Vajda S, Porco JA, Kelley MR, Georgiadis MM. Discovery of macrocyclic inhibitors of Apurinic/apyrimidinic endonuclease 1. Journal of Medicinal Chemistry. PMID 30653918 DOI: 10.1021/Acs.Jmedchem.8B01529 |
0.788 |
|
| 2018 |
Kearney SE, Zahoránszky-Kőhalmi G, Brimacombe KR, Henderson MJ, Lynch C, Zhao T, Wan KK, Itkin Z, Dillon C, Shen M, Cheff DM, Lee TD, Bougie D, Cheng K, Coussens NP, ... ... Porco JA, et al. Canvass: A Crowd-Sourced, Natural-Product Screening Library for Exploring Biological Space. Acs Central Science. 4: 1727-1741. PMID 30648156 DOI: 10.1021/Acscentsci.8B00747 |
0.714 |
|
| 2018 |
Zhang W, Liu S, Maiga RI, Pelletier J, Brown LE, Wang TT, Porco JA. Chemical Synthesis Enables Structural Reengineering of Aglaroxin C Leading to Inhibition Bias for HCV Infection. Journal of the American Chemical Society. PMID 30590924 DOI: 10.1021/Jacs.8B11477 |
0.545 |
|
| 2018 |
Smith MJ, Reichl KD, Escobar RA, Heavey T, Coker DF, Schaus SE, Porco JA. Asymmetric Synthesis of Griffipavixanthone Employing a Chiral Phosphoric Acid-Catalyzed Cycloaddition. Journal of the American Chemical Society. PMID 30566336 DOI: 10.1021/Jacs.8B12520 |
0.797 |
|
| 2018 |
Nalli AD, Brown LE, Thomas CL, Sayers TJ, Porco JA, Henrich CJ. Sensitization of renal carcinoma cells to TRAIL-induced apoptosis by rocaglamide and analogs. Scientific Reports. 8: 17519. PMID 30504817 DOI: 10.1038/S41598-018-35908-0 |
0.462 |
|
| 2018 |
Chennamadhavuni S, Panek JS, Porco JA, Brown LE. Diastereodivergent synthesis of chiral tetrahydropyrrolodiazepinediones via a one-pot intramolecular aza-Michael/lactamization sequence. The Journal of Organic Chemistry. PMID 30458107 DOI: 10.1021/Acs.Joc.8B02724 |
0.806 |
|
| 2018 |
Yang X, Jounaidi Y, Dai JB, Marte-Oquendo F, Halpin ES, Brown LE, Trilles R, Xu W, Daigle R, Yu B, Schaus SE, Porco JA, Forman SA. High-throughput Screening in Larval Zebrafish Identifies Novel Potent Sedative-hypnotics. Anesthesiology. PMID 29894316 DOI: 10.1097/Aln.0000000000002281 |
0.524 |
|
| 2018 |
Langlais D, Cencic R, Moradin N, Kennedy JM, Ayi K, Brown LE, Crandall I, Tarry MJ, Schmeing M, Kain KC, Porco JA, Pelletier J, Gros P. Rocaglates as dual-targeting agents for experimental cerebral malaria. Proceedings of the National Academy of Sciences of the United States of America. PMID 29463745 DOI: 10.1073/Pnas.1713000115 |
0.452 |
|
| 2018 |
Porco J, Qi C, Wang W, Reichl K, McNeely J. Total Synthesis of Aurofusarin: Studies of the Atropisomeric Stability of Bis-Naphthoquinones. Angewandte Chemie (International Ed. in English). PMID 29318760 DOI: 10.1002/Anie.201711535 |
0.617 |
|
| 2017 |
Porco J, Wang W, Clay A, Krishnan R, Lajkiewicz NJ, Brown LE, Sivaguru J. Total Syntheses of the Isomeric Aglain Natural Products Foveoglin A and Perviridisin B via Selective ESIPT Photocycloaddition. Angewandte Chemie (International Ed. in English). PMID 28950418 DOI: 10.1002/Anie.201707539 |
0.789 |
|
| 2017 |
Reichl KD, Smith MJ, Song MK, Johnson R, Porco JA. Biomimetic Total Synthesis of (±)-Griffipavixanthone via a Cationic Cycloaddition-Cyclization Cascade. Journal of the American Chemical Society. PMID 28942643 DOI: 10.1021/Jacs.7B09265 |
0.321 |
|
| 2017 |
Manier S, Huynh D, Shen YJ, Zhou J, Yusufzai T, Salem KZ, Ebright RY, Shi J, Park J, Glavey SV, Devine WG, Liu CJ, Leleu X, Quesnel B, Roche-Lestienne C, ... ... Porco JA, et al. Inhibiting the oncogenic translation program is an effective therapeutic strategy in multiple myeloma. Science Translational Medicine. 9. PMID 28490664 DOI: 10.1126/Scitranslmed.Aal2668 |
0.651 |
|
| 2016 |
Hayashi M, Brown LE, Porco JA. Asymmetric Dearomatization/Cyclization Enables Access to Polycyclic Chemotypes. European Journal of Organic Chemistry. 2016: 4800-4804. PMID 28082832 DOI: 10.1002/Ejoc.201601003 |
0.511 |
|
| 2016 |
Ingham OJ, Paranal RM, Smith WB, Escobar RA, Yueh H, Snyder T, Porco JA, Bradner JE, Beeler AB. Development of a Potent and Selective HDAC8 Inhibitor. Acs Medicinal Chemistry Letters. 7: 929-932. PMID 27774131 DOI: 10.1021/acsmedchemlett.6b00239 |
0.44 |
|
| 2016 |
Boyce JH, Eschenbrenner-Lux V, Porco JA. Syntheses of (+)-30-epi-, (-)-6-epi-, (±)-6,30-epi-13,14-Didehydroxyisogarcinol and (±)-6,30-epi-Garcimultiflorone A Utilizing Highly Diastereoselective, Lewis Acid-Controlled Cyclizations. Journal of the American Chemical Society. 138: 14789-14797. PMID 27744695 DOI: 10.1021/jacs.6b09727 |
0.785 |
|
| 2016 |
Porco J, Wang W, Cencic R, Whitesell L, Pelletier J. Synthesis of Aza-Rocaglates via ESIPT-Mediated (3+2) Photocycloaddition. Chemistry (Weinheim An Der Bergstrasse, Germany). PMID 27338157 DOI: 10.1002/Chem.201602953 |
0.671 |
|
| 2016 |
Qi C, Xiong Y, Eschenbrenner-Lux V, Cong H, Porco JA. Asymmetric Syntheses of the Flavonoid Diels-Alder Natural Products Sanggenons C and O. Journal of the American Chemical Society. PMID 26735066 DOI: 10.1021/Jacs.5B12778 |
0.56 |
|
| 2016 |
Hayashi M, Brown LE, Porco JA. Asymmetric Dearomatization/Cyclization Enables Access to Polycyclic Chemotypes European Journal of Organic Chemistry. DOI: 10.1002/ejoc.201601003 |
0.514 |
|
| 2015 |
Liu S, Wang W, Brown LE, Qiu C, Lajkiewicz N, Zhao T, Zhou J, Porco JA, Wang TT. A Novel Class of Small Molecule Compounds that Inhibit Hepatitis C Virus Infection by Targeting the Prohibitin-CRaf Pathway. Ebiomedicine. 2: 1600-6. PMID 26870784 DOI: 10.1016/J.Ebiom.2015.09.018 |
0.775 |
|
| 2015 |
Chu J, Cencic R, Wang W, Porco JA, Pelletier J. Translation Inhibition by Rocaglates is Independent of eIF4E Phosphorylation Status. Molecular Cancer Therapeutics. PMID 26586722 DOI: 10.1158/1535-7163.Mct-15-0409 |
0.591 |
|
| 2015 |
Qin T, Iwata T, Ransom TT, Beutler JA, Porco JA. Syntheses of Dimeric Tetrahydroxanthones with Varied Linkages: Investigation of "Shapeshifting" Properties. Journal of the American Chemical Society. PMID 26544765 DOI: 10.1021/Jacs.5B09825 |
0.542 |
|
| 2015 |
Gervais A, Lazarski KE, Porco JA. Divergent Total Syntheses of Rhodomyrtosones A and B. The Journal of Organic Chemistry. 80: 9584-91. PMID 26351970 DOI: 10.1021/Acs.Joc.5B01570 |
0.59 |
|
| 2015 |
Yeo AT, Chennamadhavuni S, Whitty A, Porco JA, Gilmore TD. Inhibition of Oncogenic Transcription Factor REL by the Natural Product Derivative Calafianin Monomer 101 Induces Proliferation Arrest and Apoptosis in Human B-Lymphoma Cell Lines. Molecules (Basel, Switzerland). 20: 7474-94. PMID 25915462 DOI: 10.3390/Molecules20057474 |
0.766 |
|
| 2015 |
Stone SD, Lajkiewicz NJ, Whitesell L, Hilmy A, Porco JA. Biomimetic kinetic resolution: highly enantio- and diastereoselective transfer hydrogenation of aglain ketones to access flavagline natural products. Journal of the American Chemical Society. 137: 525-30. PMID 25514979 DOI: 10.1021/Ja511728B |
0.807 |
|
| 2015 |
Liu S, Wang W, Brown LE, Qiu C, Lajkiewicz N, Zhao T, Zhou J, Porco JA, Wang TT. A Novel Class of Small Molecule Compounds that Inhibit Hepatitis C Virus Infection by Targeting the Prohibitin-CRaf Pathway Ebiomedicine. DOI: 10.1016/j.ebiom.2015.09.018 |
0.778 |
|
| 2014 |
Yeung CS, Ziegler RE, Porco JA, Jacobsen EN. Thiourea-catalyzed enantioselective addition of indoles to pyrones: alkaloid cores with quaternary carbons. Journal of the American Chemical Society. 136: 13614-7. PMID 25213353 DOI: 10.1021/Ja508523G |
0.301 |
|
| 2014 |
Zhu L, Qi J, Chiao CY, Zhang Q, Porco JA, Faller DV, Dai Y. Identification of a novel polyprenylated acylphloroglucinol‑derived SIRT1 inhibitor with cancer‑specific anti-proliferative and invasion-suppressing activities. International Journal of Oncology. 45: 2128-36. PMID 25189993 DOI: 10.3892/Ijo.2014.2639 |
0.46 |
|
| 2014 |
Grenning AJ, Boyce JH, Porco JA. Rapid synthesis of polyprenylated acylphloroglucinol analogs via dearomative conjunctive allylic annulation. Journal of the American Chemical Society. 136: 11799-804. PMID 25061804 DOI: 10.1021/ja5060302 |
0.813 |
|
| 2014 |
Villar EA, Beglov D, Chennamadhavuni S, Porco JA, Kozakov D, Vajda S, Whitty A. How proteins bind macrocycles. Nature Chemical Biology. 10: 723-31. PMID 25038790 DOI: 10.1038/Nchembio.1584 |
0.766 |
|
| 2014 |
Boyce JH, Porco JA. Asymmetric, stereodivergent synthesis of (-)-clusianone utilizing a biomimetic cationic cyclization. Angewandte Chemie (International Ed. in English). 53: 7832-7. PMID 24916169 DOI: 10.1002/anie.201404437 |
0.8 |
|
| 2014 |
Lajkiewicz NJ, Cognetta AB, Niphakis MJ, Cravatt BF, Porco JA. Remodeling natural products: chemistry and serine hydrolase activity of a rocaglate-derived β-lactone. Journal of the American Chemical Society. 136: 2659-64. PMID 24447064 DOI: 10.1021/Ja412431G |
0.816 |
|
| 2014 |
Grenning AJ, Snyder JK, Porco JA. Remodeling of fumagillol: discovery of an oxygen-directed oxidative Mannich reaction. Organic Letters. 16: 792-5. PMID 24410175 DOI: 10.1021/Ol4035269 |
0.728 |
|
| 2014 |
Grenning AJ, Boyce JH, Porco JA. Rapid synthesis of polyprenylated acylphloroglucinol analogs via dearomative conjunctive allylic annulation Journal of the American Chemical Society. 136: 11799-11804. DOI: 10.1021/ja5060302 |
0.807 |
|
| 2013 |
Santagata S, Mendillo ML, Tang YC, Subramanian A, Perley CC, Roche SP, Wong B, Narayan R, Kwon H, Koeva M, Amon A, Golub TR, Porco JA, Whitesell L, Lindquist S. Tight coordination of protein translation and HSF1 activation supports the anabolic malignant state. Science (New York, N.Y.). 341: 1238303. PMID 23869022 DOI: 10.1126/Science.1238303 |
0.565 |
|
| 2013 |
Winter DK, Endoma-Arias MA, Hudlicky T, Beutler JA, Porco JA. Enantioselective total synthesis and biological evaluation of (+)-kibdelone A and a tetrahydroxanthone analogue. The Journal of Organic Chemistry. 78: 7617-26. PMID 23834060 DOI: 10.1021/Jo401169Z |
0.582 |
|
| 2013 |
Xiong Y, Schaus SE, Porco JA. Metal-catalyzed cascade rearrangements of 3-alkynyl flavone ethers. Organic Letters. 15: 1962-5. PMID 23574045 DOI: 10.1021/Ol400631B |
0.482 |
|
| 2013 |
Winter DK, Sloman DL, Porco JA. Polycyclic xanthone natural products: structure, biological activity and chemical synthesis. Natural Product Reports. 30: 382-91. PMID 23334431 DOI: 10.1039/c3np20122h |
0.749 |
|
| 2012 |
Dong S, Qin T, Hamel E, Beutler JA, Porco JA. Synthesis of chamaecypanone C analogues from in situ-generated cyclopentadienones and their biological evaluation. Journal of the American Chemical Society. 134: 19782-7. PMID 23110297 DOI: 10.1021/Ja3084708 |
0.678 |
|
| 2012 |
Leng B, Chichetti S, Su S, Beeler AB, Porco JA. Synthesis of a novel chemotype via sequential metal-catalyzed cycloisomerizations. Beilstein Journal of Organic Chemistry. 8: 1338-43. PMID 23019468 DOI: 10.3762/Bjoc.8.153 |
0.506 |
|
| 2012 |
Lajkiewicz NJ, Roche SP, Gerard B, Porco JA. Enantioselective photocycloaddition of 3-hydroxyflavones: total syntheses and absolute configuration assignments of (+)-ponapensin and (+)-elliptifoline. Journal of the American Chemical Society. 134: 13108-13. PMID 22804454 DOI: 10.1021/Ja305342F |
0.803 |
|
| 2012 |
Little A, Porco JA. Total syntheses of graphisin A and sydowinin B. Organic Letters. 14: 2862-2865. PMID 22621405 DOI: 10.1021/Ol301107M |
0.658 |
|
| 2012 |
Scully SS, Porco JA. Studies toward the synthesis of the epoxykinamycin FL-120B': discovery of a decarbonylative photocyclization. Organic Letters. 14: 2646-9. PMID 22571279 DOI: 10.1021/Ol3010563 |
0.674 |
|
| 2012 |
Zhang Q, Porco JA. Total Synthesis of (±)-7-epi-Nemorosone Organic Letters. 14: 1796-1799. PMID 22449198 DOI: 10.1021/Ol300386T |
0.358 |
|
| 2012 |
Achard M, Beeler AB, Porco JA. Synthesis of azaphilone-based chemical libraries Acs Combinatorial Science. 14: 236-244. PMID 22330196 DOI: 10.1021/Co300002X |
0.305 |
|
| 2012 |
Rodrigo CM, Cencic R, Roche SP, Pelletier J, Porco JA. Synthesis of rocaglamide hydroxamates and related compounds as eukaryotic translation inhibitors: synthetic and biological studies. Journal of Medicinal Chemistry. 55: 558-62. PMID 22128783 DOI: 10.1021/Jm201263K |
0.67 |
|
| 2011 |
Scully SS, Porco JA. Asymmetric total synthesis of the epoxykinamycin FL-120 B'. Angewandte Chemie (International Ed. in English). 50: 9722-6. PMID 21953671 DOI: 10.1002/Anie.201104504 |
0.694 |
|
| 2011 |
Dong S, Cahill KJ, Kang MI, Colburn NH, Henrich CJ, Wilson JA, Beutler JA, Johnson RP, Porco JA. Microwave-based reaction screening: tandem retro-Diels-Alder/Diels-Alder cycloadditions of o-quinol dimers. The Journal of Organic Chemistry. 76: 8944-54. PMID 21942286 DOI: 10.1021/Jo201658Y |
0.631 |
|
| 2011 |
Ebada SS, Lajkiewicz N, Porco JA, Li-Weber M, Proksch P. Chemistry and biology of rocaglamides (= flavaglines) and related derivatives from aglaia species (meliaceae). Progress in the Chemistry of Organic Natural Products. 94: 1-58. PMID 21833837 DOI: 10.1007/978-3-7091-0748-5_1 |
0.758 |
|
| 2011 |
Brown LE, Dai P, Porco JA, Schaus SE. Gold catalyzed cyclization of alkyne-tethered dihydropyrimidones. Organic Letters. 13: 4228-31. PMID 21749159 DOI: 10.1021/Ol2015658 |
0.532 |
|
| 2011 |
Medeiros MR, Schaus SE, Porco JA. A cycloisomerization/Friedel-Crafts alkylation strategy for the synthesis of pyrano[3,4-b]indoles. Organic Letters. 13: 4012-5. PMID 21740020 DOI: 10.1021/Ol201532K |
0.321 |
|
| 2011 |
Sloman DL, Bacon JW, Porco JA. Total synthesis and absolute stereochemical assignment of kibdelone C. Journal of the American Chemical Society. 133: 9952-5. PMID 21648477 DOI: 10.1021/Ja203642N |
0.769 |
|
| 2011 |
Wu J, Becerril J, Lian Y, Davies HM, Porco JA, Panek JS. Sequential transformations to access polycyclic chemotypes: asymmetric crotylation and metal carbenoid reactions. Angewandte Chemie (International Ed. in English). 50: 5938-42. PMID 21560214 DOI: 10.1002/Anie.201101366 |
0.427 |
|
| 2011 |
Roche SP, Porco JA. Dearomatization strategies in the synthesis of complex natural products. Angewandte Chemie (International Ed. in English). 50: 4068-93. PMID 21506209 DOI: 10.1002/anie.201006017 |
0.645 |
|
| 2011 |
Brown LE, Chih-Chien Cheng K, Wei WG, Yuan P, Dai P, Trilles R, Ni F, Yuan J, MacArthur R, Guha R, Johnson RL, Su XZ, Dominguez MM, Snyder JK, Beeler AB, ... ... Porco JA, et al. Discovery of new antimalarial chemotypes through chemical methodology and library development. Proceedings of the National Academy of Sciences of the United States of America. 108: 6775-80. PMID 21498685 DOI: 10.1073/Pnas.1017666108 |
0.482 |
|
| 2011 |
Germain AR, Bruggemeyer DM, Zhu J, Genet C, O'Brien P, Porco JA. Synthesis of the azaphilones (+)-sclerotiorin and (+)-8-O-methylsclerotiorinamine utilizing (+)-sparteine surrogates in copper-mediated oxidative dearomatization. The Journal of Organic Chemistry. 76: 2577-84. PMID 21401026 DOI: 10.1021/Jo102448N |
0.659 |
|
| 2011 |
Sloman DL, Mitasev B, Scully SS, Beutler JA, Porco JA. Synthesis and biological evaluation of ABCD ring fragments of the kibdelones. Angewandte Chemie (International Ed. in English). 50: 2511-5. PMID 21370327 DOI: 10.1002/Anie.201007613 |
0.778 |
|
| 2011 |
Xia B, Gerard B, Solano DM, Wan J, Jones G, Porco JA. ESIPT-mediated photocycloadditions of 3-hydroxyquinolinones: development of a fluorescence quenching assay for reaction screening. Organic Letters. 13: 1346-9. PMID 21338078 DOI: 10.1021/Ol200032F |
0.506 |
|
| 2010 |
Zhang Q, Mitasev B, Qi J, Porco JA. Total synthesis of plukenetione A. Journal of the American Chemical Society. 132: 14212-5. PMID 20843036 DOI: 10.1021/Ja105784S |
0.781 |
|
| 2010 |
Qi J, Beeler AB, Zhang Q, Porco JA. Catalytic enantioselective alkylative dearomatization-annulation: total synthesis and absolute configuration assignment of hyperibone K. Journal of the American Chemical Society. 132: 13642-4. PMID 20831187 DOI: 10.1021/Ja1057828 |
0.472 |
|
| 2010 |
Roche SP, Cencic R, Pelletier J, Porco JA. Biomimetic photocycloaddition of 3-hydroxyflavones: synthesis and evaluation of rocaglate derivatives as inhibitors of eukaryotic translation. Angewandte Chemie (International Ed. in English). 49: 6533-8. PMID 20687060 DOI: 10.1002/Anie.201003212 |
0.623 |
|
| 2010 |
Marié JC, Xiong Y, Min GK, Yeager AR, Taniguchi T, Berova N, Schaus SE, Porco JA. Enantioselective synthesis of 3,4-chromanediones via asymmetric rearrangement of 3-allyloxyflavones. The Journal of Organic Chemistry. 75: 4584-90. PMID 20527786 DOI: 10.1021/Jo100889C |
0.542 |
|
| 2009 |
Mitasev B, Porco JA. Manganese(III)-mediated transformations of phloroglucinols: a formal oxidative [4 + 2] cycloaddition leading to bicyclo[2.2.2]octadiones. Organic Letters. 11: 2285-8. PMID 19415907 DOI: 10.1021/ol900590t |
0.727 |
|
| 2009 |
Dong S, Hamel E, Bai R, Covell DG, Beutler JA, Porco JA. Enantioselective synthesis of (+)-chamaecypanone C: a novel microtubule inhibitor. Angewandte Chemie (International Ed. in English). 48: 1494-7. PMID 19140149 DOI: 10.1002/Anie.200805486 |
0.673 |
|
| 2009 |
Han C, Rangarajan S, Voukides AC, Beeler AB, Johnson R, Porco JA. Reaction discovery employing macrocycles: transannular cyclizations of macrocyclic bis-lactams. Organic Letters. 11: 413-6. PMID 19102683 DOI: 10.1021/Ol802729F |
0.543 |
|
| 2009 |
Dong S, Hamel E, Bai R, Covell DG, Beutler JA, Porco JA. Synthesis of (+)-Chamaecypanone C Synfacts. 2009: 829-829. DOI: 10.1055/S-0029-1217508 |
0.54 |
|
| 2008 |
Bordeleau ME, Robert F, Gerard B, Lindqvist L, Chen SM, Wendel HG, Brem B, Greger H, Lowe SW, Porco JA, Pelletier J. Therapeutic suppression of translation initiation modulates chemosensitivity in a mouse lymphoma model. The Journal of Clinical Investigation. 118: 2651-60. PMID 18551192 DOI: 10.1172/Jci34753 |
0.567 |
|
| 2008 |
Dong S, Zhu J, Porco JA. Enantioselective synthesis of bicyclo[2.2.2]octenones using a copper-mediated oxidative dearomatization/[4 + 2] dimerization cascade. Journal of the American Chemical Society. 130: 2738-9. PMID 18266375 DOI: 10.1021/Ja711018Z |
0.647 |
|
| 2008 |
Porco JA, Gerard B. Chapter 6 A biomimetic approach to the rocaglamides employing photogeneration of oxidopyryliums derived from 3-hydroxyflavones Strategies and Tactics in Organic Synthesis. 7. DOI: 10.1016/S1874-6004(08)80010-X |
0.53 |
|
| 2007 |
Su S, Porco JA. 1,2-dihydroisoquinolines as templates for cascade reactions to access isoquinoline alkaloid frameworks. Organic Letters. 9: 4983-6. PMID 17958365 DOI: 10.1021/Ol702176H |
0.509 |
|
| 2007 |
Qi J, Porco JA. Rapid access to polyprenylated phloroglucinols via alkylative dearomatization-annulation: total synthesis of (+/-)-clusianone(1). Journal of the American Chemical Society. 129: 12682-3. PMID 17902679 DOI: 10.1021/Ja0762339 |
0.48 |
|
| 2007 |
Gerard B, Cencic R, Pelletier J, Porco JA. Enantioselective synthesis of the complex rocaglate (-)-silvestrol. Angewandte Chemie (International Ed. in English). 46: 7831-4. PMID 17806093 DOI: 10.1002/Anie.200702707 |
0.586 |
|
| 2007 |
Peng LF, Kim SS, Matchacheep S, Lei X, Su S, Lin W, Runguphan W, Choe WH, Sakamoto N, Ikeda M, Kato N, Beeler AB, Porco JA, Schreiber SL, Chung RT. Identification of novel epoxide inhibitors of hepatitis C virus replication using a high-throughput screen. Antimicrobial Agents and Chemotherapy. 51: 3756-9. PMID 17682098 DOI: 10.1128/Aac.00233-07 |
0.759 |
|
| 2007 |
Su S, Porco JA. Synthesis of pyrrolo-isoquinolines related to the lamellarins using silver-catalyzed cycloisomerization/dipolar cycloaddition. Journal of the American Chemical Society. 129: 7744-5. PMID 17539647 DOI: 10.1021/Ja072737V |
0.556 |
|
| 2007 |
Han C, Porco JA. Synthesis of carbamates and ureas using Zr(IV)-catalyzed exchange processes. Organic Letters. 9: 1517-20. PMID 17358074 DOI: 10.1021/ol0702728 |
0.487 |
|
| 2007 |
Beeler AB, Su S, Singleton CA, Porco JA. Discovery of chemical reactions through multidimensional screening. Journal of the American Chemical Society. 129: 1413-9. PMID 17263426 DOI: 10.1021/Ja0674744 |
0.478 |
|
| 2007 |
Zhou Y, Porco JA, Snyder JK. Synthesis of 5,6,7,8-tetrahydro-1,6-naphthyridines and related heterocycles by cobalt-catalyzed [2 + 2 + 2] cyclizations. Organic Letters. 9: 393-6. PMID 17249770 DOI: 10.1021/Ol0625280 |
0.332 |
|
| 2006 |
Lei X, Porco JA. Total synthesis of the diazobenzofluorene antibiotic (-)-kinamycin C1. Journal of the American Chemical Society. 128: 14790-1. PMID 17105273 DOI: 10.1021/Ja066621V |
0.531 |
|
| 2006 |
Zhu J, Porco JA. Asymmetric syntheses of (-)-mitorubrin and related azaphilone natural products. Organic Letters. 8: 5169-71. PMID 17048870 DOI: 10.1021/Ol062233M |
0.522 |
|
| 2006 |
Porco JA, Su S, Lei X, Bardhan S, Rychnovsky SD. Total synthesis and structure assignment of (+)-hexacyclinol. Angewandte Chemie (International Ed. in English). 45: 5790-2. PMID 16871643 DOI: 10.1002/Anie.200602854 |
0.78 |
|
| 2006 |
Kleinke AS, Li C, Rabasso N, Porco JA. Total synthesis of the interleukin-1beta converting enzyme inhibitor EI-1941-2 using tandem oxa-electrocyclization/oxidation1. Organic Letters. 8: 2847-50. PMID 16774272 DOI: 10.1021/Ol060954F |
0.773 |
|
| 2006 |
Gerard B, Sangji S, O'Leary DJ, Porco JA. Enantioselective photocycloaddition mediated by chiral Brønsted acids: asymmetric synthesis of the rocaglamides. Journal of the American Chemical Society. 128: 7754-5. PMID 16771486 DOI: 10.1021/Ja062621J |
0.611 |
|
| 2006 |
Zhang CY, Parton LE, Ye CP, Krauss S, Shen R, Lin CT, Porco JA, Lowell BB. Genipin inhibits UCP2-mediated proton leak and acutely reverses obesity- and high glucose-induced beta cell dysfunction in isolated pancreatic islets. Cell Metabolism. 3: 417-27. PMID 16753577 DOI: 10.1016/J.Cmet.2006.04.010 |
0.49 |
|
| 2006 |
Bardhan S, Schmitt DC, Porco JA. Total synthesis and stereochemical assignment of the spiroisoxazoline natural product (+)-calafianin. Organic Letters. 8: 927-30. PMID 16494476 DOI: 10.1021/Ol053115M |
0.65 |
|
| 2006 |
Liang MC, Bardhan S, Pace EA, Rosman D, Beutler JA, Porco JA, Gilmore TD. Inhibition of transcription factor NF-kappaB signaling proteins IKKbeta and p65 through specific cysteine residues by epoxyquinone A monomer: correlation with its anti-cancer cell growth activity. Biochemical Pharmacology. 71: 634-45. PMID 16360644 DOI: 10.1016/J.Bcp.2005.11.013 |
0.676 |
|
| 2006 |
Liang MC, Bardhan S, Porco JA, Gilmore TD. The synthetic epoxyquinoids jesterone dimer and epoxyquinone A monomer induce apoptosis and inhibit REL (human c-Rel) DNA binding in an IkappaBalpha-deficient diffuse large B-cell lymphoma cell line. Cancer Letters. 241: 69-78. PMID 16289774 DOI: 10.1016/J.Canlet.2005.10.004 |
0.559 |
|
| 2006 |
Gerard B, Ryan J, Beeler AB, Porco JA. Synthesis of 1,4,5-trisubstituted-1,2,3-triazoles by copper-catalyzed cycloaddition-coupling of azides and terminal alkynes Tetrahedron. 62: 6405-6411. DOI: 10.1016/J.Tet.2006.04.025 |
0.547 |
|
| 2005 |
Lei X, Zaarur N, Sherman MY, Porco JA. Stereocontrolled synthesis of a complex library via elaboration of angular epoxyquinol scaffolds. The Journal of Organic Chemistry. 70: 6474-83. PMID 16050712 DOI: 10.1021/Jo050956Y |
0.544 |
|
| 2005 |
Li C, Porco JA. Synthesis of epoxyquinol A and related molecules: probing chemical reactivity of epoxyquinol dimers and 2H-pyran precursors. The Journal of Organic Chemistry. 70: 6053-65. PMID 16018703 DOI: 10.1021/Jo050897O |
0.66 |
|
| 2005 |
Han C, Lee JP, Lobkovsky E, Porco JA. Catalytic ester-amide exchange using group (IV) metal alkoxide-activator complexes. Journal of the American Chemical Society. 127: 10039-44. PMID 16011366 DOI: 10.1021/Ja0527976 |
0.468 |
|
| 2005 |
Zhu J, Grigoriadis NP, Lee JP, Porco JA. Synthesis of the azaphilones using copper-mediated enantioselective oxidative dearomatization. Journal of the American Chemical Society. 127: 9342-3. PMID 15984841 DOI: 10.1021/Ja052049G |
0.507 |
|
| 2005 |
Su S, Acquilano DE, Arumugasamy J, Beeler AB, Eastwood EL, Giguere JR, Lan P, Lei X, Min GK, Yeager AR, Zhou Y, Panek JS, Snyder JK, Schaus SE, Porco JA. Convergent synthesis of a complex oxime library using chemical domain shuffling. Organic Letters. 7: 2751-4. PMID 15957938 DOI: 10.1021/Ol051023R |
0.639 |
|
| 2005 |
Shen R, Inoue T, Forgac M, Porco JA. Synthesis of photoactivatable acyclic analogues of the lobatamides. The Journal of Organic Chemistry. 70: 3686-92. PMID 15845008 DOI: 10.1021/Jo0477751 |
0.564 |
|
| 2005 |
Wang X, Porco JA. Synthesis of the Tetracyclic Core of the Tetrapetalones through Transannular Oxidative [4+3] Cyclization Angewandte Chemie. 44: 3067-3071. PMID 15832389 DOI: 10.1002/Anie.200500247 |
0.42 |
|
| 2005 |
Porco J, Zhu J, Grigoriadis N, Lee J. Copper-Mediated Synthesis of Azaphilones Synfacts. 2006: 0001-0001. DOI: 10.1055/s-2005-921655 |
0.48 |
|
| 2005 |
Gerard B, Jones aG, Porco JA. A Biomimetic Approach to the Rocaglamides Employing Photogeneration of Oxidopyryliums Derived from 3-Hydroxyflavones [J. Am. Chem. Soc. 2004, 126, 13620−13621]. Journal of the American Chemical Society. 127: 1334-1334. DOI: 10.1021/Ja042481I |
0.518 |
|
| 2004 |
Gerard B, Jones Ii G, Porco JA. A biomimetic approach to the rocaglamides employing photogeneration of oxidopyryliums derived from 3-hydroxyflavones. Journal of the American Chemical Society. 126: 13620-1. PMID 15493911 DOI: 10.1021/Ja044798O |
0.577 |
|
| 2004 |
Wang X, Bowman EJ, Bowman BJ, Porco JA. Total synthesis of the salicylate enamide macrolide oximidine III: application of relay ring-closing metathesis. Angewandte Chemie (International Ed. in English). 43: 3601-5. PMID 15293258 DOI: 10.1002/Anie.200460042 |
0.424 |
|
| 2004 |
Zhu J, Germain AR, Porco JA. Synthesis of azaphilones and related molecules by employing cycloisomerization of o-alkynylbenzaldehydes. Angewandte Chemie (International Ed. in English). 43: 1239-43. PMID 14991787 DOI: 10.1002/Anie.200353037 |
0.645 |
|
| 2004 |
Lei X, Porco JA. Synthesis of a polymer-supported anthracene and its application as a dienophile scavenger. Organic Letters. 6: 795-8. PMID 14986977 DOI: 10.1021/Ol036502+ |
0.425 |
|
| 2004 |
Li C, Porco JA. Synthesis of the epoxyquinol dimer RKB-3564 D: utilization of an alkoxysilanol to promote [4 + 4] dimerization. Journal of the American Chemical Society. 126: 1310-1. PMID 14759167 DOI: 10.1021/Ja039543+ |
0.653 |
|
| 2004 |
Han C, Shen R, Su S, Porco JA. Copper-mediated synthesis of N-acyl vinylogous carbamic acids and derivatives: synthesis of the antibiotic CJ-15,801. Organic Letters. 6: 27-30. PMID 14703342 DOI: 10.1021/Ol0360041 |
0.722 |
|
| 2004 |
Su S, Giguere JR, Schaus SE, Porco JA. Synthesis of complex alkoxyamines using a polymer-supported N-hydroxyphthalimide Tetrahedron. 60: 8645-8657. DOI: 10.1016/J.Tet.2004.05.109 |
0.466 |
|
| 2003 |
Lei X, Johnson RP, Porco JA. Total synthesis of the ubiquitin-activating enzyme inhibitor (+)-panepophenanthrin. Angewandte Chemie (International Ed. in English). 42: 3913-7. PMID 12949867 DOI: 10.1002/Anie.200351862 |
0.488 |
|
| 2003 |
Shen R, Lin CT, Bowman EJ, Bowman BJ, Porco JA. Lobatamide C: total synthesis, stereochemical assignment, preparation of simplified analogues, and V-ATPase inhibition studies. Journal of the American Chemical Society. 125: 7889-901. PMID 12823009 DOI: 10.1021/Ja0352350 |
0.59 |
|
| 2003 |
Liang MC, Bardhan S, Li C, Pace EA, Porco JA, Gilmore TD. Jesterone dimer, a synthetic derivative of the fungal metabolite jesterone, blocks activation of transcription factor nuclear factor kappaB by inhibiting the inhibitor of kappaB kinase. Molecular Pharmacology. 64: 123-31. PMID 12815168 DOI: 10.1124/Mol.64.1.123 |
0.744 |
|
| 2003 |
Wang X, Porco JA. Total synthesis of the salicylate enamide macrolide oximidine II. Journal of the American Chemical Society. 125: 6040-6041. PMID 12785818 DOI: 10.1021/Ja034030O |
0.455 |
|
| 2003 |
Li C, Johnson RP, Porco JA. Total synthesis of the quinone epoxide dimer (+)-torreyanic acid: application of a biomimetic oxidation/electrocyclization/Diels-Alder dimerization cascade. Journal of the American Chemical Society. 125: 5095-106. PMID 12708860 DOI: 10.1021/Ja021396C |
0.698 |
|
| 2003 |
Su S, Kakeya H, Osada H, Porco JA. Synthesis and cell cycle inhibition of the peptide enamide natural products terpeptin and the aspergillamides Tetrahedron. 59: 8931-8946. DOI: 10.1016/J.Tet.2003.04.005 |
0.571 |
|
| 2002 |
Li C, Bardhan S, Pace EA, Liang MC, Gilmore TD, Porco JA. Angiogenesis inhibitor epoxyquinol a: total synthesis and inhibition of transcription factor NF-kappaB. Organic Letters. 4: 3267-70. PMID 12227765 DOI: 10.1021/Ol026513N |
0.766 |
|
| 2002 |
Shen R, Lin CT, Bowman EJ, Bowman BJ, Porco JA. Synthesis and V-ATPase inhibition of simplified lobatamide analogues. Organic Letters. 4: 3103-6. PMID 12201727 DOI: 10.1021/Ol026391Z |
0.564 |
|
| 2002 |
Shen R, Lin CT, Porco JA. Total synthesis and stereochemical assignment of the salicylate antitumor macrolide lobatamide C(1). Journal of the American Chemical Society. 124: 5650-1. PMID 12010033 DOI: 10.1021/Ja026025A |
0.592 |
|
| 2002 |
Kulkarni BA, Roth GP, Lobkovsky E, Porco JA. Combinatorial synthesis of natural product-like molecules using a first-generation spiroketal scaffold. Journal of Combinatorial Chemistry. 4: 56-72. PMID 11831883 DOI: 10.1021/CC010047W |
0.318 |
|
| 2002 |
Li C, Bardhan S, Pace EA, Liang MC, Gilmore TD, Porco JA. Angiogenesis inhibitor epoxyquinol A: Total synthesis and inhibition of transcription factor NF-κB Organic Letters. 4: 3267-3270. DOI: 10.1021/ol026513n |
0.742 |
|
| 2001 |
Wang X, Porco JA. Modification of C-terminal peptides to form peptide enamides: synthesis of chondriamides A and C. Journal of Organic Chemistry. 66: 8215-8221. PMID 11722228 DOI: 10.1021/Jo0158027 |
0.334 |
|
| 2001 |
Li C, Pace EA, Liang MC, Lobkovsky E, Gilmore TD, Porco JA. Total synthesis of the NF-kappa B inhibitor (-)-cycloepoxydon: utilization of tartrate-mediated nucleophilic epoxidation. Journal of the American Chemical Society. 123: 11308-9. PMID 11697981 DOI: 10.1021/Ja0169769 |
0.678 |
|
| 2001 |
Hu Y, Li C, Kulkarni BA, Strobel G, Lobkovsky E, Torczynski RM, Porco JA. Exploring chemical diversity of epoxyquinoid natural products: synthesis and biological activity of (-)-jesterone and related molecules. Organic Letters. 3: 1649-1652. PMID 11405677 DOI: 10.1021/Ol0159367 |
0.726 |
|
| 2000 |
Wang X, Parlow JJ, Porco JA. Parallel Synthesis and Purification Using Anthracene-Tagged Substrates Organic Letters. 2: 3509-3512. PMID 11082021 DOI: 10.1021/Ol0065625 |
0.424 |
|
| 1995 |
Wong C, Provencher L, Porco JA, Jung S, Wang Y, Chen L, Wang R, Steensma DH. Synthesis and Evaluation of Homoaza Sugars as Glycosidase Inhibitors Journal of Organic Chemistry. 60: 1492-1501. DOI: 10.1021/Jo00111A007 |
0.432 |
|
| 1988 |
Schreiber SL, Desmaele D, Porco JA. On the use of unsymmetrically substituted furans in the furan-carbonyl photocycloaddition reaction: Synthesis of a kadsurenone-ginkgolide hybrid Tetrahedron Letters. 29: 6689-6692. DOI: 10.1016/S0040-4039(00)82429-6 |
0.694 |
|
| Show low-probability matches. |
