| Year |
Citation |
Score |
| 2020 |
Wang SA, Lin CI, Zhang J, Ushimaru R, Sasaki E, Liu HW. Studies of lincosamide formation complete the biosynthetic pathway for lincomycin A. Proceedings of the National Academy of Sciences of the United States of America. PMID 32958639 DOI: 10.1073/Pnas.2009306117 |
0.776 |
|
| 2020 |
Ren D, Ruszczycky MW, Ko Y, Wang SA, Ogasawara Y, Kim M, Liu HW. Characterization of the coformycin biosynthetic gene cluster in . Proceedings of the National Academy of Sciences of the United States of America. PMID 32350138 DOI: 10.1073/Pnas.2000111117 |
0.452 |
|
| 2019 |
Liu HW, Ushimaru R, Chen Z, Zhao H, Fan PH. The Enzymes Mediating Maturation of the Seryl-tRNA Synthetase Inhibitor SB-217452 during Biosynthesis of Albomycins. Angewandte Chemie (International Ed. in English). PMID 31863717 DOI: 10.1002/Anie.201915275 |
0.782 |
|
| 2019 |
Ruszczycky MW, Liu HW. Measurement of Net Rate Constants from Enzyme Progress Curves without Curve Fitting. Biochemistry. PMID 31710808 DOI: 10.1021/Acs.Biochem.9B00762 |
0.404 |
|
| 2019 |
Ren D, Wang SA, Ko Y, Geng Y, Ogasawara Y, Liu HW. Identification of the C-Glycoside Synthases during Biosynthesis of the Pyrazole-C-Nucleosides Formycin and Pyrazofurin. Angewandte Chemie (International Ed. in English). PMID 31518483 DOI: 10.1002/Anie.201910356 |
0.359 |
|
| 2019 |
Romo AJ, Shiraishi T, Ikeuchi H, Lin GM, Geng Y, Lee YH, Liem PH, Ma T, Ogasawara Y, Shin-Ya K, Nishiyama M, Kuzuyama T, Liu HW. The Amipurimycin and Miharamycin Biosynthetic Gene Clusters: Unraveling the Origins of 2-Aminopurinyl Peptidyl Nucleoside Antibiotics. Journal of the American Chemical Society. PMID 31150226 DOI: 10.1021/Jacs.9B03021 |
0.358 |
|
| 2019 |
Thibodeaux CJ, Chang WC, Liu HW. Unraveling flavoenzyme reaction mechanisms using flavin analogues and linear free energy relationships. Methods in Enzymology. 620: 167-188. PMID 31072486 DOI: 10.1016/Bs.Mie.2019.03.010 |
0.736 |
|
| 2019 |
Wang SA, Ko Y, Zeng J, Geng Y, Ren D, Ogasawara Y, Irani S, Zhang YJ, Liu HW. Identification of the Formycin A Biosynthetic Gene Cluster from Streptomyces kaniharaensis Illustrates the Interplay between Biological Pyrazolopyrimidine Formation and de novo Purine Biosynthesis. Journal of the American Chemical Society. PMID 30942582 DOI: 10.1021/Jacs.9B00241 |
0.362 |
|
| 2019 |
Pan HX, Chen Z, Zeng T, Jin WB, Geng Y, Lin GM, Zhao J, Li WT, Xiong Z, Huang SX, Zhai X, Liu HW, Tang GL. Elucidation of the Herbicidin Tailoring Pathway Offers Insights into Its Structural Diversity. Organic Letters. PMID 30763106 DOI: 10.1021/Acs.Orglett.9B00066 |
0.356 |
|
| 2019 |
Ban YH, Song MC, Hwang JY, Shin HL, Kim HJ, Hong SK, Lee NJ, Park JW, Cha SS, Liu HW, Yoon YJ. Author Correction: Complete reconstitution of the diverse pathways of gentamicin B biosynthesis. Nature Chemical Biology. PMID 30728495 DOI: 10.1038/s41589-019-0232-7 |
0.552 |
|
| 2019 |
Ushimaru R, Liu HW. Biosynthetic Origin of the Atypical Stereochemistry in the Thioheptose Core of Albomycin Nucleoside Antibiotics. Journal of the American Chemical Society. PMID 30673214 DOI: 10.1021/Jacs.8B12565 |
0.761 |
|
| 2019 |
Ban YH, Song MC, Hwang JY, Shin HL, Kim HJ, Hong SK, Lee NJ, Park JW, Cha SS, Liu HW, Yoon YJ. Complete reconstitution of the diverse pathways of gentamicin B biosynthesis. Nature Chemical Biology. PMID 30643280 DOI: 10.1038/s41589-018-0203-4 |
0.682 |
|
| 2019 |
Liu H, Ushimaru R, Chen Z, zhao H, Fan P. The Enzymes Mediating Maturation of the Seryl-tRNA Synthetase Inhibitor SB-217452 during Biosynthesis of Albomycins. Angewandte Chemie. DOI: 10.1002/Ange.201915275 |
0.755 |
|
| 2018 |
Ushimaru R, Ruszczycky MW, Liu HW. Changes in regioselectivity of H atom abstraction during the hydroxylation and cyclization reactions catalyzed by hyoscyamine 6β-hydroxylase. Journal of the American Chemical Society. PMID 30545219 DOI: 10.1021/Jacs.8B11585 |
0.745 |
|
| 2018 |
Ushimaru R, Ruszczycky MW, Chang WC, Yan F, Liu YN, Liu HW. Substrate Conformation Correlates with the Outcome of Hyoscyamine 6β-Hydroxylase Catalyzed Oxidation Reactions. Journal of the American Chemical Society. PMID 29870653 DOI: 10.1021/Jacs.8B03729 |
0.759 |
|
| 2018 |
Huang C, Yang C, Zhang W, Zhang L, De BC, Zhu Y, Jiang X, Fang C, Zhang Q, Yuan CS, Liu HW, Zhang C. Molecular basis of dimer formation during the biosynthesis of benzofluorene-containing atypical angucyclines. Nature Communications. 9: 2088. PMID 29802272 DOI: 10.1038/S41467-018-04487-Z |
0.614 |
|
| 2018 |
Ruszczycky MW, Zhong A, Liu HW. Following the electrons: peculiarities in the catalytic cycles of radical SAM enzymes. Natural Product Reports. PMID 29485151 DOI: 10.1039/C7Np00058H |
0.774 |
|
| 2018 |
Ko Y, Lin GM, Ruszczycky MW, Liu HW. Mechanistic Implications of the Deamination of TDP-4-amino-4-deoxy-D-fucose Catalyzed by the Radical SAM Enzyme DesII. Biochemistry. PMID 29473739 DOI: 10.1021/Acs.Biochem.8B00110 |
0.482 |
|
| 2017 |
Lin GM, Romo A, Liem P, Chen Z, Liu HW. Identification and Interrogation of the Herbicidin Biosynthetic Gene Cluster: First Insight into the Biosynthesis of a Rare Undecose Nucleoside Antibiotic. Journal of the American Chemical Society. PMID 29111702 DOI: 10.1021/Jacs.7B08985 |
0.326 |
|
| 2017 |
Zhang Q, Li H, Yu L, Sun Y, Zhu Y, Zhu H, Zhang L, Li SM, Shen Y, Tian C, Li A, Liu HW, Zhang C. Characterization of the flavoenzyme XiaK as an N-hydroxylase and implications in indolosesquiterpene diversification. Chemical Science. 8: 5067-5077. PMID 28970893 DOI: 10.1039/C7Sc01182B |
0.591 |
|
| 2017 |
Ruszczycky MW, Liu HW. Theory and Application of the Relationship Between Steady-State Isotope Effects on Enzyme Intermediate Concentrations and Net Rate Constants. Methods in Enzymology. 596: 459-499. PMID 28911781 DOI: 10.1016/Bs.Mie.2017.07.022 |
0.42 |
|
| 2017 |
Jeon BS, Ruszczycky MW, Russell WK, Lin GM, Kim N, Choi SH, Wang SA, Liu YN, Patrick JW, Russell DH, Liu HW. Investigation of the mechanism of the SpnF-catalyzed [4+2]-cycloaddition reaction in the biosynthesis of spinosyn A. Proceedings of the National Academy of Sciences of the United States of America. PMID 28874588 DOI: 10.1073/Pnas.1710496114 |
0.393 |
|
| 2017 |
Thibodeaux CJ, Liu HW. The type II isopentenyl Diphosphate:Dimethylallyl diphosphate isomerase (IDI-2): A model for acid/base chemistry in flavoenzyme catalysis. Archives of Biochemistry and Biophysics. PMID 28577910 DOI: 10.1016/J.Abb.2017.05.017 |
0.769 |
|
| 2017 |
Jeon BS, Wang SA, Ruszczycky MW, Liu HW. Natural [4 + 2]-Cyclases. Chemical Reviews. 117: 5367-5388. PMID 28441874 DOI: 10.1021/Acs.Chemrev.6B00578 |
0.506 |
|
| 2017 |
Ko Y, Wang SA, Ogasawara Y, Ruszczycky MW, Liu HW. Identification and Characterization of Enzymes Catalyzing Pyrazolopyrimidine Formation in the Biosynthesis of Formycin A. Organic Letters. PMID 28233490 DOI: 10.1021/Acs.Orglett.7B00355 |
0.47 |
|
| 2016 |
Bridwell-Rabb J, Kang G, Zhong A, Liu HW, Drennan CL. An HD domain phosphohydrolase active site tailored for oxetanocin-A biosynthesis. Proceedings of the National Academy of Sciences of the United States of America. 113: 13750-13755. PMID 27849620 DOI: 10.1073/Pnas.1613610113 |
0.769 |
|
| 2016 |
Liu HW, Lin CI, McCarty RM. Name Reactions in Biological Chemistry. Angewandte Chemie (International Ed. in English). PMID 27505692 DOI: 10.1002/Anie.201603291 |
0.392 |
|
| 2016 |
Ushimaru R, Lin CI, Sasaki E, Liu HW. Characterization of Enzymes Catalyzing Transformations of Cysteine S-Conjugated Intermediates in the Lincosamide Biosynthetic Pathway. Chembiochem : a European Journal of Chemical Biology. PMID 27431934 DOI: 10.1002/Cbic.201600223 |
0.8 |
|
| 2016 |
Lin GM, Sun HG, Liu HW. Study of Uridine 5'-Diphosphate (UDP)-Galactopyranose Mutase Using UDP-5-Fluorogalactopyranose as a Probe: Incubation Results and Mechanistic Implications. Organic Letters. PMID 27384425 DOI: 10.1021/Acs.Orglett.6B01618 |
0.397 |
|
| 2016 |
He W, Liu M, Li X, Zhang X, Abdel-Mageed WM, Li L, Wang W, Zhang J, Han J, Dai H, Quinn RJ, Liu HW, Luo H, Zhang L, Liu X. Fungal biotransformation of tanshinone results in [4+2] cycloaddition with sorbicillinol: evidence for enzyme catalysis and increased antibacterial activity. Applied Microbiology and Biotechnology. PMID 27198724 DOI: 10.1007/S00253-016-7488-6 |
0.449 |
|
| 2016 |
Patel A, Chen Z, Yang Z, Gutierrez O, Liu HW, Houk KN, Singleton DA. Dynamically complex [6+4] and [4+2] cycloadditions in the biosynthesis of spinosyn A. Journal of the American Chemical Society. PMID 26909570 DOI: 10.1021/Jacs.6B00017 |
0.386 |
|
| 2016 |
Kim HJ, LeVieux J, Yeh YC, Liu HW. C3'-Deoxygenation of Paromamine Catalyzed by a Radical S-Adenosylmethionine Enzyme: Characterization of the Enzyme AprD4 and its Reductase Partner AprD3. Angewandte Chemie (International Ed. in English). PMID 26879038 DOI: 10.1002/anie.201510635 |
0.674 |
|
| 2016 |
Jackson D, Yu X, Wang G, Patel A, Barajas J, Sasaki E, Metsa-Ketala M, Liu HW, Rohr J, Tsai SS. Insights Into Complex Oxidation During BE-7585A Biosynthesis: Structural Determination and Analysis of the Polyketide Monooxygenase BexE. Acs Chemical Biology. PMID 26813028 DOI: 10.1021/Acschembio.5B00913 |
0.388 |
|
| 2015 |
Caldara-Festin G, Jackson DR, Barajas JF, Valentic TR, Patel AB, Aguilar S, Nguyen M, Vo M, Khanna A, Sasaki E, Liu HW, Tsai SC. Structural and functional analysis of two di-domain aromatase/cyclases from type II polyketide synthases. Proceedings of the National Academy of Sciences of the United States of America. PMID 26631750 DOI: 10.1073/Pnas.1512976112 |
0.337 |
|
| 2015 |
Lin GM, Choi SH, Ruszczycky MW, Liu HW. Mechanistic Investigation of the Radical S-Adenosyl-L-methionine Enzyme DesII Using Fluorinated Analogues. Journal of the American Chemical Society. 137: 4964-7. PMID 25826575 DOI: 10.1021/Jacs.5B02545 |
0.48 |
|
| 2015 |
Fage CD, Isiorho EA, Liu Y, Wagner DT, Liu HW, Keatinge-Clay AT. The structure of SpnF, a standalone enzyme that catalyzes [4 + 2] cycloaddition. Nature Chemical Biology. 11: 256-8. PMID 25730549 DOI: 10.1038/Nchembio.1768 |
0.446 |
|
| 2015 |
Hashimoto T, Hashimoto J, Teruya K, Hirano T, Shin-ya K, Ikeda H, Liu HW, Nishiyama M, Kuzuyama T. Biosynthesis of versipelostatin: identification of an enzyme-catalyzed [4+2]-cycloaddition required for macrocyclization of spirotetronate-containing polyketides. Journal of the American Chemical Society. 137: 572-5. PMID 25551461 DOI: 10.1021/ja510711x |
0.372 |
|
| 2015 |
Ruszczycky MW, Liu HW. Mechanistic enzymology of the radical SAM enzyme DesII Israel Journal of Chemistry. 55: 315-324. DOI: 10.1002/ijch.201400130 |
0.356 |
|
| 2014 |
Kim HJ, Choi SH, Jeon BS, Kim N, Pongdee R, Wu Q, Liu HW. Chemoenzymatic synthesis of spinosyn A. Angewandte Chemie (International Ed. in English). 53: 13553-7. PMID 25287333 DOI: 10.1002/anie.201407806 |
0.623 |
|
| 2014 |
Sasaki E, Zhang X, Sun HG, Lu MY, Liu TL, Ou A, Li JY, Chen YH, Ealick SE, Liu HW. Co-opting sulphur-carrier proteins from primary metabolic pathways for 2-thiosugar biosynthesis. Nature. 510: 427-31. PMID 24814342 DOI: 10.1038/nature13256 |
0.311 |
|
| 2014 |
Mansoorabadi SO, Wu M, Tao Z, Gao P, Pingali SV, Guo L, Liu HW. Conformational activation of poly(ADP-ribose) polymerase-1 upon DNA binding revealed by small-angle X-ray scattering. Biochemistry. 53: 1779-88. PMID 24588584 DOI: 10.1021/Bi401439N |
0.668 |
|
| 2014 |
Lin CI, Sasaki E, Zhong A, Liu HW. In vitro characterization of LmbK and LmbO: identification of GDP-D-erythro-α-D-gluco-octose as a key intermediate in lincomycin A biosynthesis. Journal of the American Chemical Society. 136: 906-9. PMID 24380627 DOI: 10.1021/Ja412194W |
0.756 |
|
| 2013 |
Swedenborg PD, Jones RL, Zhou HQ, Shin I, Liu HW. Biological activity of (3R,5S,6R)- and (3S,5R,6S)-3,5-dimethyl-6-(methylethyl)-3,4,5,6-tetrahydropyran-2-one, a pheromone ofMacrocentrus grandii (Goidanich) (Hymenoptera: Braconidae). Journal of Chemical Ecology. 20: 3373-80. PMID 24241999 DOI: 10.1007/BF02033733 |
0.429 |
|
| 2013 |
Wang C, Chang WC, Guo Y, Huang H, Peck SC, Pandelia ME, Lin GM, Liu HW, Krebs C, Bollinger JM. Evidence that the fosfomycin-producing epoxidase, HppE, is a non-heme-iron peroxidase. Science (New York, N.Y.). 342: 991-5. PMID 24114783 DOI: 10.1126/Science.1240373 |
0.529 |
|
| 2013 |
Liu Hw, Begley T. Natural product biosynthesis-a Renaissance Current Opinion in Chemical Biology. 17: 529-531. PMID 23891474 DOI: 10.1016/J.Cbpa.2013.07.005 |
0.499 |
|
| 2013 |
Zhao L, Chang WC, Xiao Y, Liu HW, Liu P. Methylerythritol phosphate pathway of isoprenoid biosynthesis. Annual Review of Biochemistry. 82: 497-530. PMID 23746261 DOI: 10.1146/annurev-biochem-052010-100934 |
0.323 |
|
| 2013 |
Chang WC, Mansoorabadi SO, Liu HW. Reaction of HppE with substrate analogues: evidence for carbon-phosphorus bond cleavage by a carbocation rearrangement. Journal of the American Chemical Society. 135: 8153-6. PMID 23672451 DOI: 10.1021/Ja403441X |
0.774 |
|
| 2013 |
Chang WC, Dey M, Liu P, Mansoorabadi SO, Moon SJ, Zhao ZK, Drennan CL, Liu HW. Mechanistic studies of an unprecedented enzyme-catalysed 1,2-phosphono-migration reaction. Nature. 496: 114-8. PMID 23552950 DOI: 10.1038/Nature11998 |
0.77 |
|
| 2013 |
Lin CI, McCarty RM, Liu HW. The biosynthesis of nitrogen-, sulfur-, and high-carbon chain-containing sugars. Chemical Society Reviews. 42: 4377-407. PMID 23348524 DOI: 10.1039/C2Cs35438A |
0.357 |
|
| 2012 |
Sasaki E, Lin CI, Lin KY, Liu HW. Construction of the octose 8-phosphate intermediate in lincomycin A biosynthesis: characterization of the reactions catalyzed by LmbR and LmbN. Journal of the American Chemical Society. 134: 17432-5. PMID 22989310 DOI: 10.1021/ja308221z |
0.316 |
|
| 2012 |
Isiorho EA, Liu HW, Keatinge-Clay AT. Structural studies of the spinosyn rhamnosyltransferase, SpnG. Biochemistry. 51: 1213-22. PMID 22283226 DOI: 10.1021/Bi201860Q |
0.393 |
|
| 2012 |
Sun HG, Ruszczycky MW, Chang WC, Thibodeaux CJ, Liu HW. Nucleophilic participation of reduced flavin coenzyme in mechanism of UDP-galactopyranose mutase. The Journal of Biological Chemistry. 287: 4602-8. PMID 22187430 DOI: 10.1074/Jbc.M111.312538 |
0.707 |
|
| 2012 |
Ruszczycky MW, Ogasawara Y, Liu HW. Radical SAM enzymes in the biosynthesis of sugar-containing natural products. Biochimica Et Biophysica Acta. 1824: 1231-44. PMID 22172915 DOI: 10.1016/J.Bbapap.2011.11.006 |
0.394 |
|
| 2012 |
Calveras J, Thibodeaux CJ, Mansoorabadi SO, Liu HW. Stereochemical studies of the type II isopentenyl diphosphate-dimethylallyl diphosphate isomerase implicate the FMN coenzyme in substrate protonation. Chembiochem : a European Journal of Chemical Biology. 13: 42-6. PMID 22135039 DOI: 10.1002/Cbic.201100694 |
0.822 |
|
| 2012 |
Thibodeaux CJ, Chang WC, Liu HW. Enzymatic chemistry of cyclopropane, epoxide, and aziridine biosynthesis. Chemical Reviews. 112: 1681-709. PMID 22017381 DOI: 10.1021/Cr200073D |
0.742 |
|
| 2011 |
Xiao Y, Chang WC, Liu HW, Liu P. Study of IspH, a key enzyme in the methylerythritol phosphate pathway using fluoro-substituted substrate analogues. Organic Letters. 13: 5912-5. PMID 21981393 DOI: 10.1021/ol202559r |
0.349 |
|
| 2011 |
Yun D, Dey M, Higgins LJ, Yan F, Liu HW, Drennan CL. Structural basis of regiospecificity of a mononuclear iron enzyme in antibiotic fosfomycin biosynthesis. Journal of the American Chemical Society. 133: 11262-9. PMID 21682308 DOI: 10.1021/Ja2025728 |
0.307 |
|
| 2011 |
Kim HJ, Ruszczycky MW, Choi SH, Liu YN, Liu HW. Enzyme-catalysed [4+2] cycloaddition is a key step in the biosynthesis of spinosyn A. Nature. 473: 109-12. PMID 21544146 DOI: 10.1038/Nature09981 |
0.704 |
|
| 2011 |
Ruszczycky MW, Choi SH, Mansoorabadi SO, Liu HW. Mechanistic studies of the radical S-adenosyl-L-methionine enzyme DesII: EPR characterization of a radical intermediate generated during its catalyzed dehydrogenation of TDP-D-quinovose. Journal of the American Chemical Society. 133: 7292-5. PMID 21513273 DOI: 10.1021/Ja201212F |
0.727 |
|
| 2011 |
Tempesta MS, Liu HW. Special issue in honor of Koji Nakanishi. Journal of Natural Products. 74: 303-4. PMID 21323379 DOI: 10.1021/np200089y |
0.423 |
|
| 2011 |
Romo AJ, Liu HW. Mechanisms and structures of vitamin B(6)-dependent enzymes involved in deoxy sugar biosynthesis. Biochimica Et Biophysica Acta. 1814: 1534-47. PMID 21315852 DOI: 10.1016/j.bbapap.2011.02.003 |
0.435 |
|
| 2011 |
Thibodeaux CJ, Liu HW. Mechanistic studies of 1-aminocyclopropane-1-carboxylate deaminase: characterization of an unusual pyridoxal 5'-phosphate-dependent reaction. Biochemistry. 50: 1950-62. PMID 21244019 DOI: 10.1021/Bi101927S |
0.774 |
|
| 2011 |
Wang Y-, Liu H, Zhu L-, Li X-, Chen Z. Polyaromatic Furans from Diynyl-1,6-diols Synfacts. 2011: 612-612. DOI: 10.1055/S-0030-1260409 |
0.332 |
|
| 2010 |
Sasaki E, Liu HW. Mechanistic studies of the biosynthesis of 2-thiosugar: evidence for the formation of an enzyme-bound 2-ketohexose intermediate in BexX-catalyzed reaction. Journal of the American Chemical Society. 132: 15544-6. PMID 20961106 DOI: 10.1021/Ja108061C |
0.483 |
|
| 2010 |
Borisova SA, Guppi SR, Kim HJ, Wu B, Penn JH, Liu HW, O'Doherty GA. A de novo approach to the synthesis of glycosylated methymycin analogues with structural and stereochemical diversity. Organic Letters. 12: 5150-3. PMID 20958086 DOI: 10.1021/Ol102144G |
0.602 |
|
| 2010 |
Thibodeaux CJ, Chang WC, Liu HW. Linear free energy relationships demonstrate a catalytic role for the flavin mononucleotide coenzyme of the type II isopentenyl diphosphate:dimethylallyl diphosphate isomerase. Journal of the American Chemical Society. 132: 9994-6. PMID 20593767 DOI: 10.1021/Ja104090M |
0.749 |
|
| 2009 |
Ogasawara Y, Liu HW. Biosynthetic studies of aziridine formation in azicemicins. Journal of the American Chemical Society. 131: 18066-8. PMID 19928906 DOI: 10.1021/Ja907307H |
0.395 |
|
| 2009 |
Szu PH, Ruszczycky MW, Choi SH, Yan F, Liu HW. Characterization and mechanistic studies of DesII: a radical S-adenosyl-L-methionine enzyme involved in the biosynthesis of TDP-D-desosamine. Journal of the American Chemical Society. 131: 14030-42. PMID 19746907 DOI: 10.1021/Ja903354K |
0.461 |
|
| 2009 |
White-Phillip J, Thibodeaux CJ, Liu HW. Enzymatic synthesis of TDP-deoxysugars. Methods in Enzymology. 459: 521-44. PMID 19362653 DOI: 10.1016/S0076-6879(09)04621-7 |
0.771 |
|
| 2008 |
Thibodeaux CJ, Melançon CE, Liu HW. Natural-product sugar biosynthesis and enzymatic glycodiversification. Angewandte Chemie (International Ed. in English). 47: 9814-59. PMID 19058170 DOI: 10.1002/Anie.200801204 |
0.819 |
|
| 2008 |
Munos JW, Moon SJ, Mansoorabadi SO, Chang W, Hong L, Yan F, Liu A, Liu HW. Purification and characterization of the epoxidase catalyzing the formation of fosfomycin from Pseudomonas syringae. Biochemistry. 47: 8726-35. PMID 18656958 DOI: 10.1021/Bi800877V |
0.739 |
|
| 2008 |
Borisova SA, Kim HJ, Pu X, Liu HW. Glycosylation of acyclic and cyclic aglycone substrates by macrolide glycosyltransferase DesVII/DesVIII: analysis and implications. Chembiochem : a European Journal of Chemical Biology. 9: 1554-8. PMID 18548476 DOI: 10.1002/Cbic.200800155 |
0.651 |
|
| 2008 |
Smith P, Szu PH, Bui C, Liu HW, Tsai SC. Structure and mutagenic conversion of E1 dehydrase: at the crossroads of dehydration, amino transfer, and epimerization. Biochemistry. 47: 6329-41. PMID 18491919 DOI: 10.1021/bi702449p |
0.324 |
|
| 2008 |
Liautard V, Desvergnes V, Itoh K, Liu HW, Martin OR. Convergent and stereoselective synthesis of iminosugar-containing Galf and UDP-Galf mimicks: evaluation as inhibitors of UDP-Gal mutase. The Journal of Organic Chemistry. 73: 3103-15. PMID 18358048 DOI: 10.1021/jo8001134 |
0.316 |
|
| 2008 |
Hong L, Zhao Z, Melançon CE, Zhang H, Liu HW. In vitro characterization of the enzymes involved in TDP-D-forosamine biosynthesis in the spinosyn pathway of Saccharopolyspora spinosa. Journal of the American Chemical Society. 130: 4954-67. PMID 18345667 DOI: 10.1021/Ja0771383 |
0.746 |
|
| 2008 |
Thibodeaux CJ, Mansoorabadi SO, Kittleman W, Chang WC, Liu HW. Evidence for the involvement of acid/base chemistry in the reaction catalyzed by the type II isopentenyl diphosphate/dimethylallyl diphosphate isomerase from Staphylococcus aureus. Biochemistry. 47: 2547-58. PMID 18229948 DOI: 10.1021/Bi701467G |
0.813 |
|
| 2008 |
Munos JW, Pu X, Liu HW. Synthesis and analysis of a fluorinated product analogue as an inhibitor for 1-deoxy-D-xylulose 5-phosphate reductoisomerase. Bioorganic & Medicinal Chemistry Letters. 18: 3090-4. PMID 18078746 DOI: 10.1016/j.bmcl.2007.11.062 |
0.372 |
|
| 2008 |
Thibodeaux C, Melançon C, Liu H. Biosynthese von Naturstoffzuckern und enzymatische Glycodiversifizierung Angewandte Chemie. 120: 9960-10007. DOI: 10.1002/Ange.200801204 |
0.76 |
|
| 2007 |
Kim HJ, Pongdee R, Wu Q, Hong L, Liu HW. The biosynthesis of spinosyn in Saccharopolyspora spinosa: synthesis of the cross-bridging precursor and identification of the function of SpnJ. Journal of the American Chemical Society. 129: 14582-4. PMID 17985910 DOI: 10.1021/Ja076580I |
0.694 |
|
| 2007 |
Zhang H, White-Phillip JA, Melançon CE, Kwon HJ, Yu WL, Liu HW. Elucidation of the kijanimicin gene cluster: insights into the biosynthesis of spirotetronate antibiotics and nitrosugars. Journal of the American Chemical Society. 129: 14670-83. PMID 17985890 DOI: 10.1021/Ja0744854 |
0.77 |
|
| 2007 |
Kittleman W, Thibodeaux CJ, Liu YN, Zhang H, Liu HW. Characterization and mechanistic studies of type II isopentenyl diphosphate:dimethylallyl diphosphate isomerase from Staphylococcus aureus. Biochemistry. 46: 8401-13. PMID 17585782 DOI: 10.1021/Bi700286A |
0.774 |
|
| 2007 |
Mansoorabadi SO, Thibodeaux CJ, Liu HW. The diverse roles of flavin coenzymes--nature's most versatile thespians. The Journal of Organic Chemistry. 72: 6329-42. PMID 17580897 DOI: 10.1021/Jo0703092 |
0.812 |
|
| 2007 |
Thibodeaux CJ, Melançon CE, Liu HW. Unusual sugar biosynthesis and natural product glycodiversification. Nature. 446: 1008-16. PMID 17460661 DOI: 10.1038/Nature05814 |
0.817 |
|
| 2007 |
Melançon CE, Liu HW. Engineered biosynthesis of macrolide derivatives bearing the non-natural deoxysugars 4-epi-D-mycaminose and 3-n-monomethylamino-3-deoxy-D-fucose. Journal of the American Chemical Society. 129: 4896-7. PMID 17388593 DOI: 10.1021/Ja068254T |
0.763 |
|
| 2007 |
Wu Q, Liu YN, Chen H, Molitor EJ, Liu HW. A retro-evolution study of CDP-6-deoxy-D-glycero-L-threo-4-hexulose-3-dehydrase (E1) from Yersinia pseudotuberculosis: implications for C-3 deoxygenation in the biosynthesis of 3,6-dideoxyhexoses. Biochemistry. 46: 3759-67. PMID 17323931 DOI: 10.1021/bi602352g |
0.319 |
|
| 2007 |
Melançon CE, Hong L, White JA, Liu YN, Liu HW. Characterization of TDP-4-keto-6-deoxy-D-glucose-3,4-ketoisomerase from the D-mycaminose biosynthetic pathway of Streptomyces fradiae: in vitro activity and substrate specificity studies. Biochemistry. 46: 577-90. PMID 17209568 DOI: 10.1021/Bi061907Y |
0.795 |
|
| 2007 |
Thibodeaux CJ, Liu H. Manipulating nature's sugar biosynthetic machineries for glycodiversification of macrolides: Recent advances and future prospects Pure and Applied Chemistry. 79: 785-799. DOI: 10.1351/Pac200779040785 |
0.718 |
|
| 2006 |
Melançon CE, Thibodeaux CJ, Liu HW. Glyco-stripping and glyco-swapping. Acs Chemical Biology. 1: 499-504. PMID 17168536 DOI: 10.1021/Cb600365Q |
0.816 |
|
| 2006 |
Hong L, Zhao Z, Liu HW. Characterization of SpnQ from the spinosyn biosynthetic pathway of Saccharopolyspora spinosa: mechanistic and evolutionary implications for C-3 deoxygenation in deoxysugar biosynthesis. Journal of the American Chemical Society. 128: 14262-3. PMID 17076492 DOI: 10.1021/ja0649670 |
0.334 |
|
| 2006 |
Borisova SA, Zhang C, Takahashi H, Zhang H, Wong AW, Thorson JS, Liu HW. Substrate specificity of the macrolide-glycosylating enzyme pair DesVII/DesVIII: opportunities, limitations, and mechanistic hypotheses. Angewandte Chemie (International Ed. in English). 45: 2748-53. PMID 16538696 DOI: 10.1002/Anie.200503195 |
0.701 |
|
| 2005 |
Kao CL, Kittleman W, Zhang H, Seto H, Liu HW. Stereochemical analysis of isopentenyl diphosphate isomerase type II from Staphylococcus aureus using chemically synthesized (S)- and (R)-[2-2H]isopentenyl diphosphates. Organic Letters. 7: 5677-80. PMID 16321020 DOI: 10.1021/Ol0524050 |
0.71 |
|
| 2005 |
Melançon CE, Yu WL, Liu HW. TDP-mycaminose biosynthetic pathway revised and conversion of desosamine pathway to mycaminose pathway with one gene. Journal of the American Chemical Society. 127: 12240-1. PMID 16131199 DOI: 10.1021/Ja053835O |
0.7 |
|
| 2005 |
Higgins LJ, Yan F, Liu P, Liu HW, Drennan CL. Structural insight into antibiotic fosfomycin biosynthesis by a mononuclear iron enzyme. Nature. 437: 838-44. PMID 16015285 DOI: 10.1038/Nature03924 |
0.466 |
|
| 2005 |
Takahashi H, Liu YN, Chen H, Liu HW. Biosynthesis of TDP-l-mycarose: the specificity of a single enzyme governs the outcome of the pathway. Journal of the American Chemical Society. 127: 9340-1. PMID 15984840 DOI: 10.1021/Ja051409X |
0.428 |
|
| 2005 |
Zhao Z, Hong L, Liu HW. Characterization of protein encoded by spnR from the spinosyn gene cluster of Saccharopolyspora spinosa: mechanistic implications for forosamine biosynthesis. Journal of the American Chemical Society. 127: 7692-3. PMID 15913355 DOI: 10.1021/ja042702k |
0.309 |
|
| 2005 |
Alam J, Beyer N, Liu HW. Biosynthesis of colitose: expression, purification, and mechanistic characterization of GDP-4-keto-6-deoxy-D-mannose-3-dehydrase (ColD) and GDP-L-colitose synthase (ColC). Biochemistry. 43: 16450-60. PMID 15610039 DOI: 10.1021/bi0483763 |
0.306 |
|
| 2005 |
Pongdee R, Liu HW. Elucidation of enzyme mechanisms using fluorinated substrate analogues. Bioorganic Chemistry. 32: 393-437. PMID 15381404 DOI: 10.1016/j.bioorg.2004.06.012 |
0.408 |
|
| 2005 |
Pongdee R, Liu H. The Chemistry of Metabolic and Biosynthetic Pathways Chemistry & Biology. 12: 149-150. DOI: 10.1016/J.Chembiol.2005.02.001 |
0.449 |
|
| 2004 |
Melançon CE, Takahashi H, Liu HW. Characterization of tylM3/tylM2 and mydC/mycB pairs required for efficient glycosyltransfer in macrolide antibiotic biosynthesis. Journal of the American Chemical Society. 126: 16726-7. PMID 15612702 DOI: 10.1021/Ja043900E |
0.728 |
|
| 2004 |
Agnihotri G, Liu YN, Paschal BM, Liu HW. Identification of an unusual [2Fe-2S]-binding motif in the CDP-6-deoxy-D-glycero-l-threo-4-hexulose-3-dehydrase from Yersinia pseudotuberculosis: implication for C-3 deoxygenation in the biosynthesis of 3,6-dideoxyhexoses. Biochemistry. 43: 14265-74. PMID 15518577 DOI: 10.1021/Bi048841W |
0.341 |
|
| 2004 |
Karthikeyan S, Zhou Q, Zhao Z, Kao CL, Tao Z, Robinson H, Liu HW, Zhang H. Structural analysis of Pseudomonas 1-aminocyclopropane-1-carboxylate deaminase complexes: insight into the mechanism of a unique pyridoxal-5'-phosphate dependent cyclopropane ring-opening reaction. Biochemistry. 43: 13328-39. PMID 15491139 DOI: 10.1021/bi048878g |
0.718 |
|
| 2004 |
Rétey J, Liu HW. The elucidation of fascinating new enzyme-catalysed reactions continues. Current Opinion in Chemical Biology. 8: 451-3. PMID 15450485 DOI: 10.1016/J.Cbpa.2004.08.015 |
0.358 |
|
| 2004 |
Wong A, Munos JW, Devasthali V, Johnson KA, Liu HW. Study of 1-deoxy-D-xylulose-5-phosphate reductoisomerase: Synthesis and evaluation of fluorinated substrate analogues Organic Letters. 6: 3625-3628. PMID 15387564 DOI: 10.1021/Ol048459B |
0.448 |
|
| 2004 |
Liu P, Mehn MP, Yan F, Zhao Z, Que L, Liu HW. Oxygenase activity in the self-hydroxylation of (s)-2-hydroxypropylphosphonic acid epoxidase involved in fosfomycin biosynthesis. Journal of the American Chemical Society. 126: 10306-12. PMID 15315444 DOI: 10.1021/Ja0475050 |
0.356 |
|
| 2004 |
Karthikeyan S, Zhao Z, Kao CL, Zhou Q, Tao Z, Zhang H, Liu HW. Structural analysis of 1-aminocyclopropane-1-carboxylate deaminase: observation of an aminyl intermediate and identification of Tyr 294 as the active-site nucleophile. Angewandte Chemie (International Ed. in English). 43: 3425-9. PMID 15221829 DOI: 10.1002/anie.200453353 |
0.654 |
|
| 2004 |
Borisova SA, Zhao L, Melançon III CE, Kao CL, Liu HW. Characterization of the glycosyltransferase activity of desVII: analysis of and implications for the biosynthesis of macrolide antibiotics. Journal of the American Chemical Society. 126: 6534-5. PMID 15161264 DOI: 10.1021/Ja049967J |
0.678 |
|
| 2004 |
Vogan EM, Bellamacina C, He X, Liu HW, Ringe D, Petsko GA. Crystal structure at 1.8 A resolution of CDP-D-glucose 4,6-dehydratase from Yersinia pseudotuberculosis. Biochemistry. 43: 3057-67. PMID 15023057 DOI: 10.1021/Bi035547F |
0.319 |
|
| 2004 |
Huang Z, Zhang Q, Liu HW. Reconstitution of UDP-galactopyranose mutase with 1-deaza-FAD and 5-deaza-FAD: analysis and mechanistic implications. Bioorganic Chemistry. 31: 494-502. PMID 14613770 DOI: 10.1016/j.bioorg.2003.08.002 |
0.373 |
|
| 2003 |
Zhao L, Beyer NJ, Borisova SA, Liu HW. Beta-glucosylation as a part of self-resistance mechanism in methymycin/pikromycin producing strain Streptomyces venezuelae. Biochemistry. 42: 14794-804. PMID 14674753 DOI: 10.1021/Bi035501M |
0.376 |
|
| 2003 |
Molitor EJ, Paschal BM, Liu HW. Cyclopropane fatty acid synthase from Escherichia coli: enzyme purification and inhibition by vinylfluorine and epoxide-containing substrate analogues. Chembiochem : a European Journal of Chemical Biology. 4: 1352-6. PMID 14661280 DOI: 10.1002/Cbic.200300767 |
0.435 |
|
| 2003 |
Leriche C, He X, Chang CW, Liu HW. Reversal of the apparent regiospecificity of NAD(P)H-dependent hydride transfer: the properties of the difluoromethylene group, a carbonyl mimic. Journal of the American Chemical Society. 125: 6348-9. PMID 12785757 DOI: 10.1021/Ja021487+ |
0.371 |
|
| 2003 |
Beyer N, Alam J, Hallis TM, Guo Z, Liu HW. The biosynthesis of GDP-L-colitose: C-3 deoxygenation is catalyzed by a unique coenzyme B6-dependent enzyme. Journal of the American Chemical Society. 125: 5584-5. PMID 12733868 DOI: 10.1021/Ja030088R |
0.478 |
|
| 2003 |
Koropatkin NM, Liu HW, Holden HM. High resolution x-ray structure of tyvelose epimerase from Salmonella typhi. The Journal of Biological Chemistry. 278: 20874-81. PMID 12642575 DOI: 10.1074/Jbc.M301948200 |
0.396 |
|
| 2003 |
Zhao Z, Chen H, Li K, Du W, He S, Liu HW. Reaction of 1-amino-2-methylenecyclopropane-1-carboxylate with 1-aminocyclopropane-1-carboxylate deaminase: analysis and mechanistic implications. Biochemistry. 42: 2089-103. PMID 12590597 DOI: 10.1021/Bi020567N |
0.464 |
|
| 2003 |
Agnihotri G, Liu HW. Enoyl-CoA hydratase. reaction, mechanism, and inhibition. Bioorganic & Medicinal Chemistry. 11: 9-20. PMID 12467702 DOI: 10.1016/S0968-0896(02)00333-4 |
0.379 |
|
| 2003 |
He X, Liu HW. Mechanisms of enzymatic CbondO bond cleavages in deoxyhexose biosynthesis. Current Opinion in Chemical Biology. 6: 590-7. PMID 12413542 DOI: 10.1016/S1367-5931(02)00367-8 |
0.325 |
|
| 2002 |
Chen H, Yamase H, Murakami K, Chang CW, Zhao L, Zhao Z, Liu HW. Expression, purification, and characterization of two N,N-dimethyltransferases, tylM1 and desVI, involved in the biosynthesis of mycaminose and desosamine. Biochemistry. 41: 9165-83. PMID 12119032 DOI: 10.1021/Bi020245J |
0.41 |
|
| 2002 |
Zhao Z, Liu HW. Synthesis of labeled 1-amino-2-methylenecyclopropane-1-carboxylic acid, an inactivator of 1-aminocyclopropane-1-carboxylate deaminase. The Journal of Organic Chemistry. 67: 2509-14. PMID 11950295 DOI: 10.1021/jo010994r |
0.354 |
|
| 2002 |
Agnihotri G, He S, Hong L, Dakoji S, Withers SG, Liu HW. A revised mechanism for the inactivation of bovine liver enoyl-CoA hydratase by (methylenecyclopropyl)formyl-CoA based on unexpected results with the C114A mutant. Biochemistry. 41: 1843-52. PMID 11827529 DOI: 10.1021/Bi0119363 |
0.312 |
|
| 2001 |
He XM, Liu HW. Formation of unusual sugars: mechanistic studies and biosynthetic applications. Annual Review of Biochemistry. 71: 701-54. PMID 12045109 DOI: 10.1146/annurev.biochem.71.110601.135339 |
0.359 |
|
| 2000 |
Hallis TM, Zhao Z, Liu H. New Insights into the Mechanism of CDP-d-Tyvelose 2-Epimerase: An Enzyme-Catalyzing Epimerization at an Unactivated Stereocenter Journal of the American Chemical Society. 122: 10493-10503. DOI: 10.1021/ja0022021 |
0.346 |
|
| 1999 |
Chen H, Agnihotri G, Guo Z, Que NLS, Chen XH, Liu H. Biosynthesis of Mycarose: Isolation and Characterization of Enzymes Involved in the C-2 Deoxygenation Journal of the American Chemical Society. 121: 8124-8125. DOI: 10.1021/Ja991713O |
0.311 |
|
| 1998 |
Hallis TM, Lei Y, Que NL, Liu H. Mechanistic studies of the biosynthesis of paratose: purification and characterization of CDP-paratose synthase. Biochemistry. 37: 4935-45. PMID 9538012 DOI: 10.1021/bi9725529 |
0.429 |
|
| 1984 |
Hill RK, Prakash SR, Wiesendanger R, Angst W, Martinoni B, Arigoni D, Liu HW, Walsh CT. Stereochemistry of the enzymatic ring opening of 1-aminocyclopropanecarboxylic acid Journal of the American Chemical Society. 106: 795-796. DOI: 10.1002/Chin.198419150 |
0.369 |
|
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