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Hung-Wen (Ben) Liu - Publications

Chemistry University of Texas at Austin, Austin, Texas, U.S.A. 
Drug Design

139 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2019 Thibodeaux CJ, Chang WC, Liu HW. Unraveling flavoenzyme reaction mechanisms using flavin analogues and linear free energy relationships. Methods in Enzymology. 620: 167-188. PMID 31072486 DOI: 10.1016/Bs.Mie.2019.03.010  1
2019 Wang SA, Ko Y, Zeng J, Geng Y, Ren D, Ogasawara Y, Irani S, Zhang YJ, Liu HW. Identification of the Formycin A Biosynthetic Gene Cluster from Streptomyces kaniharaensis Illustrates the Interplay between Biological Pyrazolopyrimidine Formation and de novo Purine Biosynthesis. Journal of the American Chemical Society. PMID 30942582 DOI: 10.1021/Jacs.9B00241  1
2019 Pan HX, Chen Z, Zeng T, Jin WB, Geng Y, Lin GM, Zhao J, Li WT, Xiong Z, Huang SX, Zhai X, Liu HW, Tang GL. Elucidation of the Herbicidin Tailoring Pathway Offers Insights into Its Structural Diversity. Organic Letters. PMID 30763106 DOI: 10.1021/Acs.Orglett.9B00066  0.52
2019 Ban YH, Song MC, Hwang JY, Shin HL, Kim HJ, Hong SK, Lee NJ, Park JW, Cha SS, Liu HW, Yoon YJ. Author Correction: Complete reconstitution of the diverse pathways of gentamicin B biosynthesis. Nature Chemical Biology. PMID 30728495 DOI: 10.1038/s41589-019-0232-7  0.8
2019 Ban YH, Song MC, Hwang JY, Shin HL, Kim HJ, Hong SK, Lee NJ, Park JW, Cha SS, Liu HW, Yoon YJ. Complete reconstitution of the diverse pathways of gentamicin B biosynthesis. Nature Chemical Biology. PMID 30643280 DOI: 10.1038/s41589-018-0203-4  0.8
2018 Ushimaru R, Ruszczycky MW, Liu HW. Changes in regioselectivity of H atom abstraction during the hydroxylation and cyclization reactions catalyzed by hyoscyamine 6β-hydroxylase. Journal of the American Chemical Society. PMID 30545219 DOI: 10.1021/Jacs.8B11585  0.8
2018 Ushimaru R, Ruszczycky MW, Chang WC, Yan F, Liu YN, Liu HW. Substrate Conformation Correlates with the Outcome of Hyoscyamine 6β-Hydroxylase Catalyzed Oxidation Reactions. Journal of the American Chemical Society. PMID 29870653 DOI: 10.1021/Jacs.8B03729  0.8
2018 Huang C, Yang C, Zhang W, Zhang L, De BC, Zhu Y, Jiang X, Fang C, Zhang Q, Yuan CS, Liu HW, Zhang C. Molecular basis of dimer formation during the biosynthesis of benzofluorene-containing atypical angucyclines. Nature Communications. 9: 2088. PMID 29802272 DOI: 10.1038/S41467-018-04487-Z  0.44
2018 Ko Y, Lin GM, Ruszczycky MW, Liu HW. Mechanistic Implications of the Deamination of TDP-4-amino-4-deoxy-D-fucose Catalyzed by the Radical SAM Enzyme DesII. Biochemistry. PMID 29473739 DOI: 10.1021/Acs.Biochem.8B00110  0.8
2018 Yang Z, Yang S, Yu P, Li Y, Doubleday C, Park J, Patel A, Jeon BS, Russell WK, Liu HW, Russell DH, Houk KN. Influence of water and enzyme SpnF on the dynamics and energetics of the ambimodal [6+4]/[4+2] cycloaddition. Proceedings of the National Academy of Sciences of the United States of America. PMID 29348209 DOI: 10.1073/Pnas.1719368115  0.76
2017 Ruszczycky MW, Liu HW. Biochemistry: The surprising history of an antioxidant. Nature. 551: 37-38. PMID 29094692 DOI: 10.1038/551037A  0.8
2017 Zhang Q, Li H, Yu L, Sun Y, Zhu Y, Zhu H, Zhang L, Li SM, Shen Y, Tian C, Li A, Liu HW, Zhang C. Characterization of the flavoenzyme XiaK as an N-hydroxylase and implications in indolosesquiterpene diversification. Chemical Science. 8: 5067-5077. PMID 28970893 DOI: 10.1039/C7Sc01182B  0.44
2017 Ruszczycky MW, Liu HW. Theory and Application of the Relationship Between Steady-State Isotope Effects on Enzyme Intermediate Concentrations and Net Rate Constants. Methods in Enzymology. 596: 459-499. PMID 28911781 DOI: 10.1016/Bs.Mie.2017.07.022  0.8
2017 Jeon BS, Ruszczycky MW, Russell WK, Lin GM, Kim N, Choi SH, Wang SA, Liu YN, Patrick JW, Russell DH, Liu HW. Investigation of the mechanism of the SpnF-catalyzed [4+2]-cycloaddition reaction in the biosynthesis of spinosyn A. Proceedings of the National Academy of Sciences of the United States of America. PMID 28874588 DOI: 10.1073/Pnas.1710496114  0.8
2017 Thibodeaux CJ, Liu HW. The type II isopentenyl Diphosphate:Dimethylallyl diphosphate isomerase (IDI-2): A model for acid/base chemistry in flavoenzyme catalysis. Archives of Biochemistry and Biophysics. PMID 28577910 DOI: 10.1016/J.Abb.2017.05.017  1
2017 Ko Y, Wang SA, Ogasawara Y, Ruszczycky MW, Liu HW. Identification and Characterization of Enzymes Catalyzing Pyrazolopyrimidine Formation in the Biosynthesis of Formycin A. Organic Letters. PMID 28233490 DOI: 10.1021/Acs.Orglett.7B00355  1
2016 Bridwell-Rabb J, Kang G, Zhong A, Liu HW, Drennan CL. An HD domain phosphohydrolase active site tailored for oxetanocin-A biosynthesis. Proceedings of the National Academy of Sciences of the United States of America. 113: 13750-13755. PMID 27849620 DOI: 10.1073/Pnas.1613610113  0.44
2016 Chien JY, Tsen SD, Chien CC, Liu HW, Tung CY, Lin CH. αTAT1 downregulation induces mitotic catastrophe in HeLa and A549 cells. Cell Death Discovery. 2: 16006. PMID 27551500 DOI: 10.1038/cddiscovery.2016.6  0.36
2016 Liu HW, Zhu X, Zhang J, Zhang XB, Tan W. A red emitting two-photon fluorescent probe for dynamic imaging of redox balance meditated by a superoxide anion and GSH in living cells and tissues. The Analyst. PMID 27510432 DOI: 10.1039/c6an01178k  0.36
2016 Lin GM, Sun HG, Liu HW. Study of Uridine 5'-Diphosphate (UDP)-Galactopyranose Mutase Using UDP-5-Fluorogalactopyranose as a Probe: Incubation Results and Mechanistic Implications. Organic Letters. PMID 27384425 DOI: 10.1021/Acs.Orglett.6B01618  0.52
2016 Liu HW, Ni M, Zhang GQ, Li X, Chen H, Zhang Q, Chai W, Zhou YG, Chen JY, Liu YL, Cheng CK, Wang Y. Kinematic analysis of anterior cruciate ligament reconstruction in total knee arthroplasty. American Journal of Translational Research. 8: 2275-83. PMID 27347334  0.52
2016 Tian J, Han JJ, Zhang X, He LW, Zhang YJ, Bao L, Liu HW. New Cyclohexadepsipeptides from an Entomogenous Fungus Fusarium proliferatum and Their Cytotoxicity and Autophagy-Inducing Activity. Chemistry & Biodiversity. PMID 27233912 DOI: 10.1002/cbdv.201500262  0.48
2016 He W, Liu M, Li X, Zhang X, Abdel-Mageed WM, Li L, Wang W, Zhang J, Han J, Dai H, Quinn RJ, Liu HW, Luo H, Zhang L, Liu X. Fungal biotransformation of tanshinone results in [4+2] cycloaddition with sorbicillinol: evidence for enzyme catalysis and increased antibacterial activity. Applied Microbiology and Biotechnology. PMID 27198724 DOI: 10.1007/S00253-016-7488-6  0.36
2016 Tao QQ, Ma K, Bao L, Wang K, Han JJ, Zhang JX, Huang CY, Liu HW. New sesquiterpenoids from the edible mushroom Pleurotus cystidiosus and their inhibitory activity against α-glucosidase and PTP1B. Fitoterapia. PMID 27085303 DOI: 10.1016/j.fitote.2016.04.007  0.4
2016 Cui HH, Gu SH, Zhu XQ, Wei Y, Liu HW, Khalid HD, Guo YY, Zhang YJ. Odorant-binding and chemosensory proteins identified in the antennal transcriptome of Adelphocoris suturalis Jakovlev. Comparative Biochemistry and Physiology. Part D, Genomics & Proteomics. PMID 27085212 DOI: 10.1016/j.cbd.2016.03.001  0.48
2016 Wu G, Zhou H, Zhang P, Wang X, Li W, Zhang W, Liu X, Liu HW, Keller NP, An Z, Yin WB. Polyketide Production of Pestaloficiols and Macrodiolide Ficiolides Revealed by Manipulations of Epigenetic Regulators in an Endophytic Fungus. Organic Letters. PMID 27015125 DOI: 10.1021/Acs.Orglett.6B00562  0.4
2016 Yang H, Wei CL, Liu HW, Wu JL, Li ZG, Zhang L, Jian JB, Li YY, Tai YL, Zhang J, Zhang ZZ, Jiang CJ, Xia T, Wan XC. Genetic Divergence between Camellia sinensis and Its Wild Relatives Revealed via Genome-Wide SNPs from RAD Sequencing. Plos One. 11: e0151424. PMID 26962860 DOI: 10.1371/Journal.Pone.0151424  0.36
2016 Kim HJ, LeVieux J, Yeh YC, Liu HW. C3'-Deoxygenation of Paromamine Catalyzed by a Radical S-Adenosylmethionine Enzyme: Characterization of the Enzyme AprD4 and its Reductase Partner AprD3. Angewandte Chemie (International Ed. in English). PMID 26879038 DOI: 10.1002/anie.201510635  0.52
2016 Tao QQ, Ma K, Bao L, Wang K, Han JJ, Wang WZ, Zhang JX, Huang CY, Liu HW. Sesquiterpenoids with PTP1B Inhibitory Activity and Cytotoxicity from the Edible Mushroom Pleurotus citrinopileatus. Planta Medica. PMID 26872321 DOI: 10.1055/s-0041-111629  0.4
2016 Jackson D, Yu X, Wang G, Patel A, Barajas J, Sasaki E, Metsa-Ketala M, Liu HW, Rohr J, Tsai SS. Insights Into Complex Oxidation During BE-7585A Biosynthesis: Structural Determination and Analysis of the Polyketide Monooxygenase BexE. Acs Chemical Biology. PMID 26813028 DOI: 10.1021/Acschembio.5B00913  0.72
2015 Zhu X, Xiong M, Liu HW, Mao GJ, Zhou L, Zhang J, Hu X, Zhang XB, Tan W. A FRET-based ratiometric two-photon fluorescent probe for dual-channel imaging of nitroxyl in living cells and tissues. Chemical Communications (Cambridge, England). PMID 26562010 DOI: 10.1039/c5cc08695g  0.36
2015 Liu HW, Ni M, Li X, Chen H, Zhang GQ, Chai W, Xu M, Zhou YG, Chen JY, Wang Y. Impact of MDM2 309T>G polymorphism on sarcomagenesis. International Journal of Clinical and Experimental Medicine. 8: 12810-7. PMID 26550195  0.52
2015 Zhang J, Liu HW, Hu X, Li J, Liang LH, Zhang XB, Tan W. Efficient Two-Photon Fluorescent Probe for Nitroreductase Detection and Hypoxia Imaging in Tumor Cells and Tissues. Analytical Chemistry. PMID 26514276 DOI: 10.1021/acs.analchem.5b03336  0.36
2015 Yuan HB, Ding YX, Gu SH, Sun L, Zhu XQ, Liu HW, Dhiloo KH, Zhang YJ, Guo YY. Molecular Characterization and Expression Profiling of Odorant-Binding Proteins in Apolygus lucorum. Plos One. 10: e0140562. PMID 26466366 DOI: 10.1371/journal.pone.0140562  0.48
2015 Yang CY, Liu HW, Tsai YC, Tseng JY, Liang SC, Chen CY, Lian WN, Wei MC, Lu M, Lu RH, Lin CH, Jiang JK. Interleukin-4 receptor-targeted liposomal doxorubicin as a model for enhancing cellular uptake and antitumor efficacy in murine colorectal cancer. Cancer Biology & Therapy. 0. PMID 26436767 DOI: 10.1080/15384047.2015.1095397  0.48
2015 Chaw JR, Liu HW, Shih YC, Huang CC. New designed nerve conduits with a porous ionic cross-linked alginate/chitisan structure for nerve regeneration. Bio-Medical Materials and Engineering. 26: S95-S102. PMID 26406097 DOI: 10.3233/BME-151294  0.4
2015 Yang YL, Chang CH, Huang CC, Liu HW. Anti-inflammation and anti-apoptosis effects of pearl extract gel on UVB irradiation HaCaT cells. Bio-Medical Materials and Engineering. 26: S139-S145. PMID 26405901 DOI: 10.3233/BME-151299  0.4
2015 Liu HW, Gabos Z, Ghosh S, Roberts B, Lau H, Kerba M. Outcomes in stage I non-small cell lung cancer following the introduction of stereotactic body radiotherapy in Alberta - A population-based study. Radiotherapy and Oncology : Journal of the European Society For Therapeutic Radiology and Oncology. PMID 26349589 DOI: 10.1016/j.radonc.2015.08.027  0.4
2015 Liu H, Zhang XB, Zhang J, Wang Q, Hu X, Wang P, Tan W. An Efficient Two-Photon Fluorescent Probe with Red Emission for Imaging of Thiophenols in Living Cells and Tissues. Analytical Chemistry. PMID 26228351 DOI: 10.1021/acs.analchem.5b02021  0.36
2015 Chen H, Chai W, Li B, Ni M, Zhang GQ, Liu HW, Zhang Z, Chen JY, Zhou YG, Wang Y. Effects of β-catenin on differentially expressed genes in multiple myeloma. Journal of Huazhong University of Science and Technology. Medical Sciences = Hua Zhong Ke Ji Da Xue Xue Bao. Yi Xue Ying De Wen Ban = Huazhong Keji Daxue Xuebao. Yixue Yingdewen Ban. 35: 546-52. PMID 26223925 DOI: 10.1007/s11596-015-1468-4  0.52
2015 Liu CH, Wang SA, Ruszczycky MW, Chen H, Li K, Murakami K, Liu HW. Studies of 1-Amino-2,2-difluorocyclopropane-1-carboxylic Acid: Mechanism of Decomposition and Inhibition of 1-Aminocyclopropane-1-carboxylic Acid Deaminase. Organic Letters. PMID 26102233 DOI: 10.1021/Acs.Orglett.5B01570  1
2015 Qi QY, Ren JW, Sun LW, He LW, Bao L, Yue W, Sun QM, Yao YJ, Yin WB, Liu HW. Stucturally Diverse Sesquiterpenes Produced by a Chinese Tibet Fungus Stereum hirsutum and Their Cytotoxic and Immunosuppressant Activities. Organic Letters. 17: 3098-101. PMID 26068271 DOI: 10.1021/acs.orglett.5b01356  0.4
2015 Han JJ, Zhang L, Xu JK, Bao L, Zhao F, Chen YH, Zhang WK, Liu HW. Three new cyathane diterpenoids from the medicinal fungus Cyathus africanus. Journal of Asian Natural Products Research. 1-9. PMID 26022233 DOI: 10.1080/10286020.2015.1043900  0.4
2015 Qi QY, Li EW, Han JJ, Pei YF, Ma K, Bao L, Huang Y, Zhao F, Liu HW. New ambuic acid derivatives from the solid culture of Pestalotiopsis neglecta and their nitric oxide inhibitory activity. Scientific Reports. 5: 9958. PMID 25989228 DOI: 10.1038/srep09958  0.4
2015 Han JJ, Bao L, Tao QQ, Yao YJ, Liu XZ, Yin WB, Liu HW. Gloeophyllins A-J, Cytotoxic Ergosteroids with Various Skeletons from a Chinese Tibet Fungus Gloeophyllum abietinum. Organic Letters. 17: 2538-41. PMID 25915800 DOI: 10.1021/acs.orglett.5b01080  0.4
2015 Lin GM, Choi SH, Ruszczycky MW, Liu HW. Mechanistic Investigation of the Radical S-Adenosyl-L-methionine Enzyme DesII Using Fluorinated Analogues. Journal of the American Chemical Society. 137: 4964-7. PMID 25826575 DOI: 10.1021/Jacs.5B02545  1
2015 Liang SC, Yang CY, Tseng JY, Wang HL, Tung CY, Liu HW, Chen CY, Yeh YC, Chou TY, Yang MH, Whang-Peng J, Lin CH. ABCG2 localizes to the nucleus and modulates CDH1 expression in lung cancer cells. Neoplasia (New York, N.Y.). 17: 265-78. PMID 25810011 DOI: 10.1016/j.neo.2015.01.004  0.48
2015 Zhang J, Li Y, Tao GZ, Chen YD, Hu TH, Cao XB, Jing QM, Wang XZ, Ma YY, Wang G, Liu HW, Wang B, Xu K, Li J, Deng J, et al. Short-term rosuvastatin treatment for the prevention of contrast-induced acute kidney injury in patients receiving moderate or high volumes of contrast media: a sub-analysis of the TRACK-D study. Chinese Medical Journal. 128: 784-9. PMID 25758273 DOI: 10.4103/0366-6999.152620  0.36
2015 Fage CD, Isiorho EA, Liu Y, Wagner DT, Liu HW, Keatinge-Clay AT. The structure of SpnF, a standalone enzyme that catalyzes [4 + 2] cycloaddition. Nature Chemical Biology. 11: 256-8. PMID 25730549 DOI: 10.1038/Nchembio.1768  1
2015 Ou LJ, Li XY, Li LJ, Liu HW, Sun AM, Liu KJ. A sensitive assay for trypsin using poly(thymine)-templated copper nanoparticles as fluorescent probes. The Analyst. 140: 1871-5. PMID 25657995 DOI: 10.1039/c4an01994f  0.4
2015 Liu HW, Gräfe J, Khan R, Olivotto I, Barajas JE. Role of in vivo dosimetry with radiochromic films for dose verification during cutaneous radiation therapy. Radiation Oncology (London, England). 10: 12. PMID 25582565 DOI: 10.1186/s13014-014-0325-0  0.4
2015 Hashimoto T, Hashimoto J, Teruya K, Hirano T, Shin-ya K, Ikeda H, Liu HW, Nishiyama M, Kuzuyama T. Biosynthesis of versipelostatin: identification of an enzyme-catalyzed [4+2]-cycloaddition required for macrocyclization of spirotetronate-containing polyketides. Journal of the American Chemical Society. 137: 572-5. PMID 25551461 DOI: 10.1021/ja510711x  1
2015 Lee MY, Wang HJ, Han Y, Zhou Y, Zhao JH, Duo LN, Feng C, Hua H, Liu HW, Lin ZM, Yang Y. Lipoid Proteinosis Resulting from a Large Homozygous Deletion Affecting Part of the ECM1 Gene and Adjacent Long Non-coding RNA. Acta Dermato-Venereologica. 95: 608-10. PMID 25518807 DOI: 10.2340/00015555-2036  0.36
2015 Ko Y, Ruszczycky MW, Choi SH, Liu HW. Mechanistic studies of the radical S-adenosylmethionine enzyme DesII with TDP-D-fucose. Angewandte Chemie (International Ed. in English). 54: 860-3. PMID 25418063 DOI: 10.1002/Anie.201409540  1
2015 Ruszczycky MW, Liu HW. Mechanistic enzymology of the radical SAM enzyme DesII Israel Journal of Chemistry. 55: 315-324. DOI: 10.1002/ijch.201400130  1
2014 Qi QY, Huang L, He LW, Han JJ, Chen Q, Cai L, Liu HW. Cochlioquinone derivatives with apoptosis-inducing effects on HCT116 colon cancer cells from the phytopathogenic fungus Bipolaris luttrellii L439. Chemistry & Biodiversity. 11: 1892-9. PMID 25491333 DOI: 10.1002/cbdv.201400106  0.4
2014 Kim HJ, Choi SH, Jeon BS, Kim N, Pongdee R, Wu Q, Liu HW. Chemoenzymatic synthesis of spinosyn A. Angewandte Chemie (International Ed. in English). 53: 13553-7. PMID 25287333 DOI: 10.1002/anie.201407806  0.76
2014 Chang CH, Liu HW, Huang CC. Designed drug-release systems having various breathable polyurethane film-backed hydrocolloid acrylated adhesive layers for moisture healing. Bio-Medical Materials and Engineering. 24: 2081-8. PMID 25226905 DOI: 10.3233/BME-141018  0.4
2014 Liu HW, Chaw JR, Shih YC, Huang CC. Designed hydrocolloid interpenetrating polymeric networks for clinical applications of novel drug-carrying matrix systems using Tris (6-isocyanatohexyl) isocyanurate and hydroxypropylmethylcellulose. Bio-Medical Materials and Engineering. 24: 2065-72. PMID 25226903 DOI: 10.3233/BME-141016  0.4
2014 Isiorho EA, Jeon BS, Kim NH, Liu HW, Keatinge-Clay AT. Structural studies of the spinosyn forosaminyltransferase, SpnP. Biochemistry. 53: 4292-301. PMID 24945604 DOI: 10.1021/Bi5003629  1
2014 Sasaki E, Zhang X, Sun HG, Lu MY, Liu TL, Ou A, Li JY, Chen YH, Ealick SE, Liu HW. Co-opting sulphur-carrier proteins from primary metabolic pathways for 2-thiosugar biosynthesis. Nature. 510: 427-31. PMID 24814342 DOI: 10.1038/nature13256  1
2014 Mansoorabadi SO, Wu M, Tao Z, Gao P, Pingali SV, Guo L, Liu HW. Conformational activation of poly(ADP-ribose) polymerase-1 upon DNA binding revealed by small-angle X-ray scattering. Biochemistry. 53: 1779-88. PMID 24588584 DOI: 10.1021/Bi401439N  1
2014 Huang H, Chang WC, Lin GM, Romo A, Pai PJ, Russell WK, Russell DH, Liu HW. Mechanistic consequences of chiral radical clock probes: analysis of the mononuclear non-heme iron enzyme HppE with 2-hydroxy-3-methylenecyclopropyl radical clock substrates. Journal of the American Chemical Society. 136: 2944-7. PMID 24512048 DOI: 10.1021/Ja4100035  1
2013 Wang C, Chang WC, Guo Y, Huang H, Peck SC, Pandelia ME, Lin GM, Liu HW, Krebs C, Bollinger JM. Evidence that the fosfomycin-producing epoxidase, HppE, is a non-heme-iron peroxidase. Science (New York, N.Y.). 342: 991-5. PMID 24114783 DOI: 10.1126/Science.1240373  0.72
2013 Chang WC, Song H, Liu HW, Liu P. Current development in isoprenoid precursor biosynthesis and regulation. Current Opinion in Chemical Biology. 17: 571-9. PMID 23891475 DOI: 10.1016/j.cbpa.2013.06.020  0.72
2013 Liu Hw, Begley T. Natural product biosynthesis-a Renaissance Current Opinion in Chemical Biology. 17: 529-531. PMID 23891474 DOI: 10.1016/J.Cbpa.2013.07.005  1
2013 Zhao L, Chang WC, Xiao Y, Liu HW, Liu P. Methylerythritol phosphate pathway of isoprenoid biosynthesis. Annual Review of Biochemistry. 82: 497-530. PMID 23746261 DOI: 10.1146/annurev-biochem-052010-100934  0.72
2013 Chang WC, Dey M, Liu P, Mansoorabadi SO, Moon SJ, Zhao ZK, Drennan CL, Liu HW. Mechanistic studies of an unprecedented enzyme-catalysed 1,2-phosphono-migration reaction. Nature. 496: 114-8. PMID 23552950 DOI: 10.1038/Nature11998  1
2013 Ruszczycky MW, Choi SH, Liu HW. EPR-kinetic isotope effect study of the mechanism of radical-mediated dehydrogenation of an alcohol by the radical SAM enzyme DesII. Proceedings of the National Academy of Sciences of the United States of America. 110: 2088-93. PMID 23329328 DOI: 10.1073/Pnas.1209446110  1
2012 Isiorho EA, Liu HW, Keatinge-Clay AT. Structural studies of the spinosyn rhamnosyltransferase, SpnG. Biochemistry. 51: 1213-22. PMID 22283226 DOI: 10.1021/Bi201860Q  1
2012 Sun HG, Ruszczycky MW, Chang WC, Thibodeaux CJ, Liu HW. Nucleophilic participation of reduced flavin coenzyme in mechanism of UDP-galactopyranose mutase. The Journal of Biological Chemistry. 287: 4602-8. PMID 22187430 DOI: 10.1074/Jbc.M111.312538  1
2012 Ruszczycky MW, Ogasawara Y, Liu HW. Radical SAM enzymes in the biosynthesis of sugar-containing natural products. Biochimica Et Biophysica Acta. 1824: 1231-44. PMID 22172915 DOI: 10.1016/J.Bbapap.2011.11.006  1
2012 Calveras J, Thibodeaux CJ, Mansoorabadi SO, Liu HW. Stereochemical studies of the type II isopentenyl diphosphate-dimethylallyl diphosphate isomerase implicate the FMN coenzyme in substrate protonation. Chembiochem : a European Journal of Chemical Biology. 13: 42-6. PMID 22135039 DOI: 10.1002/Cbic.201100694  1
2012 Thibodeaux CJ, Chang WC, Liu HW. Enzymatic chemistry of cyclopropane, epoxide, and aziridine biosynthesis. Chemical Reviews. 112: 1681-709. PMID 22017381 DOI: 10.1021/Cr200073D  1
2011 Chang WC, Xiao Y, Liu HW, Liu P. Mechanistic studies of an IspH-catalyzed reaction: implications for substrate binding and protonation in the biosynthesis of isoprenoids. Angewandte Chemie (International Ed. in English). 50: 12304-7. PMID 22025241 DOI: 10.1002/anie.201104124  0.72
2011 Xiao Y, Chang WC, Liu HW, Liu P. Study of IspH, a key enzyme in the methylerythritol phosphate pathway using fluoro-substituted substrate analogues. Organic Letters. 13: 5912-5. PMID 21981393 DOI: 10.1021/ol202559r  0.72
2011 Choi SH, Ruszczycky MW, Zhang H, Liu HW. A fluoro analogue of UDP-α-D-glucuronic acid is an inhibitor of UDP-α-D-apiose/UDP-α-D-xylose synthase. Chemical Communications (Cambridge, England). 47: 10130-2. PMID 21826368 DOI: 10.1039/C1Cc13140K  1
2011 Yun D, Dey M, Higgins LJ, Yan F, Liu HW, Drennan CL. Structural basis of regiospecificity of a mononuclear iron enzyme in antibiotic fosfomycin biosynthesis. Journal of the American Chemical Society. 133: 11262-9. PMID 21682308 DOI: 10.1021/Ja2025728  1
2011 Kim HJ, Ruszczycky MW, Choi SH, Liu YN, Liu HW. Enzyme-catalysed [4+2] cycloaddition is a key step in the biosynthesis of spinosyn A. Nature. 473: 109-12. PMID 21544146 DOI: 10.1038/Nature09981  1
2011 Ruszczycky MW, Choi SH, Mansoorabadi SO, Liu HW. Mechanistic studies of the radical S-adenosyl-L-methionine enzyme DesII: EPR characterization of a radical intermediate generated during its catalyzed dehydrogenation of TDP-D-quinovose. Journal of the American Chemical Society. 133: 7292-5. PMID 21513273 DOI: 10.1021/Ja201212F  1
2011 Tempesta MS, Liu HW. Special issue in honor of Koji Nakanishi. Journal of Natural Products. 74: 303-4. PMID 21323379 DOI: 10.1021/np200089y  1
2011 Romo AJ, Liu HW. Mechanisms and structures of vitamin B(6)-dependent enzymes involved in deoxy sugar biosynthesis. Biochimica Et Biophysica Acta. 1814: 1534-47. PMID 21315852 DOI: 10.1016/j.bbapap.2011.02.003  1
2011 Thibodeaux CJ, Liu HW. Mechanistic studies of 1-aminocyclopropane-1-carboxylate deaminase: characterization of an unusual pyridoxal 5'-phosphate-dependent reaction. Biochemistry. 50: 1950-62. PMID 21244019 DOI: 10.1021/Bi101927S  1
2010 Borisova SA, Guppi SR, Kim HJ, Wu B, Penn JH, Liu HW, O'Doherty GA. A de novo approach to the synthesis of glycosylated methymycin analogues with structural and stereochemical diversity. Organic Letters. 12: 5150-3. PMID 20958086 DOI: 10.1021/Ol102144G  1
2010 Borisova SA, Liu HW. Characterization of glycosyltransferase DesVII and its auxiliary partner protein DesVIII in the methymycin/picromycin biosynthetic pathway. Biochemistry. 49: 8071-84. PMID 20695498 DOI: 10.1021/Bi1007657  1
2010 Thibodeaux CJ, Chang WC, Liu HW. Linear free energy relationships demonstrate a catalytic role for the flavin mononucleotide coenzyme of the type II isopentenyl diphosphate:dimethylallyl diphosphate isomerase. Journal of the American Chemical Society. 132: 9994-6. PMID 20593767 DOI: 10.1021/ja104090m  1
2009 Ogasawara Y, Liu HW. Biosynthetic studies of aziridine formation in azicemicins. Journal of the American Chemical Society. 131: 18066-8. PMID 19928906 DOI: 10.1021/Ja907307H  1
2009 Tao Z, Gao P, Liu HW. Studies of the expression of human poly(ADP-ribose) polymerase-1 in Saccharomyces cerevisiae and identification of PARP-1 substrates by yeast proteome microarray screening. Biochemistry. 48: 11745-54. PMID 19877712 DOI: 10.1021/bi901387k  0.36
2009 Tao Z, Gao P, Liu HW. Identification of the ADP-ribosylation sites in the PARP-1 automodification domain: analysis and implications. Journal of the American Chemical Society. 131: 14258-60. PMID 19764761 DOI: 10.1021/ja906135d  0.36
2009 Szu PH, Ruszczycky MW, Choi SH, Yan F, Liu HW. Characterization and mechanistic studies of DesII: a radical S-adenosyl-L-methionine enzyme involved in the biosynthesis of TDP-D-desosamine. Journal of the American Chemical Society. 131: 14030-42. PMID 19746907 DOI: 10.1021/Ja903354K  1
2009 White-Phillip J, Thibodeaux CJ, Liu HW. Enzymatic synthesis of TDP-deoxysugars. Methods in Enzymology. 459: 521-44. PMID 19362653 DOI: 10.1016/S0076-6879(09)04621-7  1
2008 Thibodeaux CJ, Melançon CE, Liu HW. Natural-product sugar biosynthesis and enzymatic glycodiversification. Angewandte Chemie (International Ed. in English). 47: 9814-59. PMID 19058170 DOI: 10.1002/anie.200801204  1
2008 Munos JW, Moon SJ, Mansoorabadi SO, Chang W, Hong L, Yan F, Liu A, Liu HW. Purification and characterization of the epoxidase catalyzing the formation of fosfomycin from Pseudomonas syringae. Biochemistry. 47: 8726-35. PMID 18656958 DOI: 10.1021/Bi800877V  1
2008 Borisova SA, Kim HJ, Pu X, Liu HW. Glycosylation of acyclic and cyclic aglycone substrates by macrolide glycosyltransferase DesVII/DesVIII: analysis and implications. Chembiochem : a European Journal of Chemical Biology. 9: 1554-8. PMID 18548476 DOI: 10.1002/Cbic.200800155  1
2008 Smith P, Szu PH, Bui C, Liu HW, Tsai SC. Structure and mutagenic conversion of E1 dehydrase: at the crossroads of dehydration, amino transfer, and epimerization. Biochemistry. 47: 6329-41. PMID 18491919 DOI: 10.1021/bi702449p  0.72
2008 Tao Z, Gao P, Hoffman DW, Liu HW. Domain C of human poly(ADP-ribose) polymerase-1 is important for enzyme activity and contains a novel zinc-ribbon motif. Biochemistry. 47: 5804-13. PMID 18452307 DOI: 10.1021/bi800018a  0.36
2008 Liautard V, Desvergnes V, Itoh K, Liu HW, Martin OR. Convergent and stereoselective synthesis of iminosugar-containing Galf and UDP-Galf mimicks: evaluation as inhibitors of UDP-Gal mutase. The Journal of Organic Chemistry. 73: 3103-15. PMID 18358048 DOI: 10.1021/jo8001134  1
2008 Hong L, Zhao Z, Melançon CE, Zhang H, Liu HW. In vitro characterization of the enzymes involved in TDP-D-forosamine biosynthesis in the spinosyn pathway of Saccharopolyspora spinosa. Journal of the American Chemical Society. 130: 4954-67. PMID 18345667 DOI: 10.1021/ja0771383  0.84
2008 Thibodeaux CJ, Mansoorabadi SO, Kittleman W, Chang WC, Liu HW. Evidence for the involvement of acid/base chemistry in the reaction catalyzed by the type II isopentenyl diphosphate/dimethylallyl diphosphate isomerase from Staphylococcus aureus. Biochemistry. 47: 2547-58. PMID 18229948 DOI: 10.1021/Bi701467G  1
2008 Munos JW, Pu X, Liu HW. Synthesis and analysis of a fluorinated product analogue as an inhibitor for 1-deoxy-D-xylulose 5-phosphate reductoisomerase. Bioorganic & Medicinal Chemistry Letters. 18: 3090-4. PMID 18078746 DOI: 10.1016/j.bmcl.2007.11.062  0.48
2007 Yan F, Moon SJ, Liu P, Zhao Z, Lipscomb JD, Liu A, Liu HW. Determination of the substrate binding mode to the active site iron of (S)-2-hydroxypropylphosphonic acid epoxidase using 17O-enriched substrates and substrate analogues. Biochemistry. 46: 12628-38. PMID 17927218 DOI: 10.1021/Bi701370E  1
2007 Desvergnes S, Desvergnes V, Martin OR, Itoh K, Liu HW, Py S. Stereoselective synthesis of beta-1-C-substituted 1,4-dideoxy-1,4-imino-D-galactitols and evaluation as UDP-galactopyranose mutase inhibitors. Bioorganic & Medicinal Chemistry. 15: 6443-9. PMID 17662609 DOI: 10.1016/j.bmc.2007.06.059  1
2007 Kittleman W, Thibodeaux CJ, Liu YN, Zhang H, Liu HW. Characterization and mechanistic studies of type II isopentenyl diphosphate:dimethylallyl diphosphate isomerase from Staphylococcus aureus. Biochemistry. 46: 8401-13. PMID 17585782 DOI: 10.1021/Bi700286A  1
2007 Mansoorabadi SO, Thibodeaux CJ, Liu HW. The diverse roles of flavin coenzymes--nature's most versatile thespians. The Journal of Organic Chemistry. 72: 6329-42. PMID 17580897 DOI: 10.1021/Jo0703092  1
2007 Thibodeaux CJ, Melançon CE, Liu HW. Unusual sugar biosynthesis and natural product glycodiversification. Nature. 446: 1008-16. PMID 17460661 DOI: 10.1038/nature05814  1
2007 Wu Q, Liu YN, Chen H, Molitor EJ, Liu HW. A retro-evolution study of CDP-6-deoxy-D-glycero-L-threo-4-hexulose-3-dehydrase (E1) from Yersinia pseudotuberculosis: implications for C-3 deoxygenation in the biosynthesis of 3,6-dideoxyhexoses. Biochemistry. 46: 3759-67. PMID 17323931 DOI: 10.1021/bi602352g  0.76
2007 Melançon CE, Hong L, White JA, Liu YN, Liu HW. Characterization of TDP-4-keto-6-deoxy-D-glucose-3,4-ketoisomerase from the D-mycaminose biosynthetic pathway of Streptomyces fradiae: in vitro activity and substrate specificity studies. Biochemistry. 46: 577-90. PMID 17209568 DOI: 10.1021/Bi061907Y  0.52
2006 Melançon CE, Thibodeaux CJ, Liu HW. Glyco-stripping and glyco-swapping. Acs Chemical Biology. 1: 499-504. PMID 17168536 DOI: 10.1021/cb600365q  1
2006 Hong L, Zhao Z, Liu HW. Characterization of SpnQ from the spinosyn biosynthetic pathway of Saccharopolyspora spinosa: mechanistic and evolutionary implications for C-3 deoxygenation in deoxysugar biosynthesis. Journal of the American Chemical Society. 128: 14262-3. PMID 17076492 DOI: 10.1021/ja0649670  0.36
2006 Yan F, Munos JW, Liu P, Liu HW. Biosynthesis of fosfomycin, re-examination and re-confirmation of a unique Fe(II)- and NAD(P)H-dependent epoxidation reaction. Biochemistry. 45: 11473-81. PMID 16981707 DOI: 10.1021/bi060839c  0.72
2006 Zhang H, Zhou Y, Bao H, Liu HW. Vi antigen biosynthesis in Salmonella typhi: characterization of UDP-N-acetylglucosamine C-6 dehydrogenase (TviB) and UDP-N-acetylglucosaminuronic acid C-4 epimerase (TviC). Biochemistry. 45: 8163-73. PMID 16800641 DOI: 10.1021/bi060446d  0.64
2006 Borisova SA, Zhang C, Takahashi H, Zhang H, Wong AW, Thorson JS, Liu HW. Substrate specificity of the macrolide-glycosylating enzyme pair DesVII/DesVIII: opportunities, limitations, and mechanistic hypotheses. Angewandte Chemie (International Ed. in English). 45: 2748-53. PMID 16538696 DOI: 10.1002/Anie.200503195  1
2006 Smith P, Lin A, Szu PH, Liu HW, Tsai SC. Biosynthesis of a 3,6-dideoxyhexose: crystallization and X-ray diffraction of CDP-6-deoxy-L-threo-D-glycero-4-hexulose-3-dehydrase (E1) for ascarylose biosynthesis. Acta Crystallographica. Section F, Structural Biology and Crystallization Communications. 62: 231-4. PMID 16511309 DOI: 10.1107/S1744309106003721  0.72
2005 Kao CL, Kittleman W, Zhang H, Seto H, Liu HW. Stereochemical analysis of isopentenyl diphosphate isomerase type II from Staphylococcus aureus using chemically synthesized (S)- and (R)-[2-2H]isopentenyl diphosphates. Organic Letters. 7: 5677-80. PMID 16321020 DOI: 10.1021/Ol0524050  0.64
2005 Szu PH, He X, Zhao L, Liu HW. Biosynthesis of TDP-D-desosamine: identification of a strategy for C4 deoxygenation. Angewandte Chemie (International Ed. in English). 44: 6742-6. PMID 16187386 DOI: 10.1002/anie.200501998  0.72
2005 Yan F, Li T, Lipscomb JD, Liu A, Liu HW. Site-directed mutagenesis and spectroscopic studies of the iron-binding site of (S)-2-hydroxypropylphosphonic acid epoxidase. Archives of Biochemistry and Biophysics. 442: 82-91. PMID 16150418 DOI: 10.1016/J.Abb.2005.07.024  1
2005 Melançon CE, Yu WL, Liu HW. TDP-mycaminose biosynthetic pathway revised and conversion of desosamine pathway to mycaminose pathway with one gene. Journal of the American Chemical Society. 127: 12240-1. PMID 16131199 DOI: 10.1021/ja053835o  0.84
2005 Higgins LJ, Yan F, Liu P, Liu HW, Drennan CL. Structural insight into antibiotic fosfomycin biosynthesis by a mononuclear iron enzyme. Nature. 437: 838-44. PMID 16015285 DOI: 10.1038/Nature03924  1
2005 Takahashi H, Liu YN, Chen H, Liu HW. Biosynthesis of TDP-l-mycarose: the specificity of a single enzyme governs the outcome of the pathway. Journal of the American Chemical Society. 127: 9340-1. PMID 15984840 DOI: 10.1021/Ja051409X  0.32
2005 Pongdee R, Liu HW. Elucidation of enzyme mechanisms using fluorinated substrate analogues. Bioorganic Chemistry. 32: 393-437. PMID 15381404 DOI: 10.1016/j.bioorg.2004.06.012  0.32
2004 Melançon CE, Takahashi H, Liu HW. Characterization of tylM3/tylM2 and mydC/mycB pairs required for efficient glycosyltransfer in macrolide antibiotic biosynthesis. Journal of the American Chemical Society. 126: 16726-7. PMID 15612702 DOI: 10.1021/Ja043900E  0.84
2004 Agnihotri G, Liu YN, Paschal BM, Liu HW. Identification of an unusual [2Fe-2S]-binding motif in the CDP-6-deoxy-D-glycero-l-threo-4-hexulose-3-dehydrase from Yersinia pseudotuberculosis: implication for C-3 deoxygenation in the biosynthesis of 3,6-dideoxyhexoses. Biochemistry. 43: 14265-74. PMID 15518577 DOI: 10.1021/Bi048841W  1
2004 Karthikeyan S, Zhou Q, Zhao Z, Kao CL, Tao Z, Robinson H, Liu HW, Zhang H. Structural analysis of Pseudomonas 1-aminocyclopropane-1-carboxylate deaminase complexes: insight into the mechanism of a unique pyridoxal-5'-phosphate dependent cyclopropane ring-opening reaction. Biochemistry. 43: 13328-39. PMID 15491139 DOI: 10.1021/bi048878g  0.64
2004 Rétey J, Liu HW. The elucidation of fascinating new enzyme-catalysed reactions continues. Current Opinion in Chemical Biology. 8: 451-3. PMID 15450485 DOI: 10.1016/J.Cbpa.2004.08.015  1
2004 Wong A, Munos JW, Devasthali V, Johnson KA, Liu HW. Study of 1-deoxy-D-xylulose-5-phosphate reductoisomerase: Synthesis and evaluation of fluorinated substrate analogues Organic Letters. 6: 3625-3628. PMID 15387564 DOI: 10.1021/Ol048459B  1
2004 Liu P, Mehn MP, Yan F, Zhao Z, Que L, Liu HW. Oxygenase activity in the self-hydroxylation of (s)-2-hydroxypropylphosphonic acid epoxidase involved in fosfomycin biosynthesis. Journal of the American Chemical Society. 126: 10306-12. PMID 15315444 DOI: 10.1021/Ja0475050  1
2004 Karthikeyan S, Zhao Z, Kao CL, Zhou Q, Tao Z, Zhang H, Liu HW. Structural analysis of 1-aminocyclopropane-1-carboxylate deaminase: observation of an aminyl intermediate and identification of Tyr 294 as the active-site nucleophile. Angewandte Chemie (International Ed. in English). 43: 3425-9. PMID 15221829 DOI: 10.1002/anie.200453353  0.64
2004 Borisova SA, Zhao L, Melançon III CE, Kao CL, Liu HW. Characterization of the glycosyltransferase activity of desVII: analysis of and implications for the biosynthesis of macrolide antibiotics. Journal of the American Chemical Society. 126: 6534-5. PMID 15161264 DOI: 10.1021/Ja049967J  1
2004 Vogan EM, Bellamacina C, He X, Liu HW, Ringe D, Petsko GA. Crystal structure at 1.8 A resolution of CDP-D-glucose 4,6-dehydratase from Yersinia pseudotuberculosis. Biochemistry. 43: 3057-67. PMID 15023057 DOI: 10.1021/Bi035547F  1
2004 Rocklin AM, Kato K, Liu HW, Que L, Lipscomb JD. Mechanistic studies of 1-aminocyclopropane-1-carboxylic acid oxidase: single turnover reaction. Journal of Biological Inorganic Chemistry : Jbic : a Publication of the Society of Biological Inorganic Chemistry. 9: 171-82. PMID 14714198 DOI: 10.1007/S00775-003-0510-3  1
2003 Zhao L, Beyer NJ, Borisova SA, Liu HW. Beta-glucosylation as a part of self-resistance mechanism in methymycin/pikromycin producing strain Streptomyces venezuelae. Biochemistry. 42: 14794-804. PMID 14674753 DOI: 10.1021/Bi035501M  1
2003 Molitor EJ, Paschal BM, Liu HW. Cyclopropane fatty acid synthase from Escherichia coli: enzyme purification and inhibition by vinylfluorine and epoxide-containing substrate analogues. Chembiochem : a European Journal of Chemical Biology. 4: 1352-6. PMID 14661280 DOI: 10.1002/Cbic.200300767  1
2003 Liu P, Liu A, Yan F, Wolfe MD, Lipscomb JD, Liu HW. Biochemical and spectroscopic studies on (S)-2-hydroxypropylphosphonic acid epoxidase: a novel mononuclear non-heme iron enzyme. Biochemistry. 42: 11577-86. PMID 14529267 DOI: 10.1021/Bi030140W  1
2003 Koropatkin NM, Liu HW, Holden HM. High resolution x-ray structure of tyvelose epimerase from Salmonella typhi. The Journal of Biological Chemistry. 278: 20874-81. PMID 12642575 DOI: 10.1074/jbc.M301948200  1
2002 Lis L, Koltun ES, Liu HW, Kass SR. Ring scission of diastereomeric 4-butylspiropentylcarbinyl radicals as a chemical model for identifying enzyme-catalyzed FAD adducts resulting from spiropentylacetyl-CoA. Journal of the American Chemical Society. 124: 1276-87. PMID 11841297 DOI: 10.1021/Ja0114862  1
2002 Vogan EM, Bellamacina CR, He X, Foxman BM, Ringe D, Liu HW, Petsko GA. Purification, crystallization and molecular symmetry of CDP-D-glucose 4,6-dehydratase from Yersinia pseudotuberculosis. Acta Crystallographica. Section D, Biological Crystallography. 58: 370-3. PMID 11807280 DOI: 10.1107/S0907444901021473  1
2001 Liu P, Murakami K, Seki T, He X, Yeung SM, Kuzuyama T, Seto H, Liu H. Protein purification and function assignment of the epoxidase catalyzing the formation of fosfomycin. Journal of the American Chemical Society. 123: 4619-20. PMID 11457256 DOI: 10.1021/ja004153y  1
2001 Chen H, Zhao Z, Hallis TM, Guo Z, Liu Hw. Insights into the Branched-Chain Formation of Mycarose: Methylation Catalyzed by an (S)-Adenosylmethionine-Dependent Methyltransferase We are grateful to Dr. Eugene Seno and the Lilly Research Laboratories for their generous gift of the plasmid pHJL311 and to the National Institutes of Health for grants (GM 35 906 and 54 346). H.-w.L. also thanks the National Institute of General Medical Sciences for a MERIT Award. T.M.H. was a trainee of the National Institute of General Medical Sciences (Biotechnology Training Grant: 2 T32 GM08347). Angewandte Chemie (International Ed. in English). 40: 607-610. PMID 11180386 DOI: 10.1002/1521-3773(20010202)40:3<607::AID-ANIE607>3.0.CO;2-8  0.48
1984 Hall S, Darling SD, Boyer GL, Reichardt PB, Liu HW. Dinoflagellate neurotoxins related to saxitoxin: Structures of toxins C3 and C4, and confirmation of the structure of neosaxitoxin Tetrahedron Letters. 25: 3537-3538. DOI: 10.1016/S0040-4039(01)91069-X  1
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