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Stewart Shuman - Publications

Affiliations: 
Weill Cornell Medical College, New York, NY, United States 
Area:
Molecular Biology, Biochemistry
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Year Citation  Score
2024 Ghosh S, Dantuluri S, Jacewicz A, Sanchez AM, Abdullahu L, Damha MJ, Schwer B, Shuman S. Characterization of tRNA splicing enzymes RNA ligase and tRNA 2'-phosphotransferase from the pathogenic fungi . Rna (New York, N.Y.). PMID 38238085 DOI: 10.1261/rna.079911.123  0.437
2023 Jacewicz A, Dantuluri S, Shuman S. Structural basis for Tpt1-catalyzed 2'-PO transfer from RNA and NADP(H) to NAD. Proceedings of the National Academy of Sciences of the United States of America. 120: e2312999120. PMID 37883434 DOI: 10.1073/pnas.2312999120  0.362
2023 Sanchez AM, Schwer B, Jork N, Jessen HJ, Shuman S. Activities, substrate specificity, and genetic interactions of fission yeast Siw14, a cysteinyl-phosphatase-type inositol pyrophosphatase. Mbio. e0205623. PMID 37772819 DOI: 10.1128/mbio.02056-23  0.345
2023 Shuman S. RNA Repair: Hiding in Plain Sight. Annual Review of Genetics. PMID 37722686 DOI: 10.1146/annurev-genet-071719-021856  0.343
2023 Garg A, Schwer B, Shuman S. Fission yeast poly(A) polymerase active site mutation Y86D alleviates the synthetic growth defect and upregulates mRNAs targeted by MTREC and Mmi1. Rna (New York, N.Y.). PMID 37586723 DOI: 10.1261/rna.079722.123  0.369
2023 Dupuy P, Ghosh S, Fay A, Adefisayo O, Gupta R, Shuman S, Glickman MS. Roles for mycobacterial DinB2 in frameshift and substitution mutagenesis. Elife. 12. PMID 37141254 DOI: 10.7554/eLife.83094  0.566
2023 Sanchez AM, Garg A, Schwer B, Shuman S. Duf89 abets lncRNA control of fission yeast phosphate homeostasis via its antagonism of precocious lncRNA transcription termination. Rna (New York, N.Y.). PMID 36882296 DOI: 10.1261/rna.079595.123  0.316
2023 Warren GM, Ejaz A, Fay A, Glickman MS, Shuman S. Mycobacterial helicase Lhr abets resistance to DNA crosslinking agents mitomycin C and cisplatin. Nucleic Acids Research. 51: 218-235. PMID 36610794 DOI: 10.1093/nar/gkac1222  0.617
2022 Benjamin B, Goldgur Y, Jork N, Jessen HJ, Schwer B, Shuman S. Structures of Fission Yeast Inositol Pyrophosphate Kinase Asp1 in Ligand-Free, Substrate-Bound, and Product-Bound States. Mbio. e0308722. PMID 36468882 DOI: 10.1128/mbio.03087-22  0.349
2022 Dupuy P, Ghosh S, Adefisayo O, Buglino J, Shuman S, Glickman MS. Distinctive roles of translesion polymerases DinB1 and DnaE2 in diversification of the mycobacterial genome through substitution and frameshift mutagenesis. Nature Communications. 13: 4493. PMID 35918328 DOI: 10.1038/s41467-022-32022-8  0.521
2022 Benjamin B, Garg A, Jork N, Jessen HJ, Schwer B, Shuman S. Activities and Structure-Function Analysis of Fission Yeast Inositol Pyrophosphate (IPP) Kinase-Pyrophosphatase Asp1 and Its Impact on Regulation of Gene Expression. Mbio. e0103422. PMID 35536002 DOI: 10.1128/mbio.01034-22  0.315
2022 Sanchez AM, Jacewicz A, Shuman S. Fission yeast Duf89 and Duf8901 are cobalt/nickel-dependent phosphatase-pyrophosphatases that act via a covalent aspartyl-phosphate intermediate. The Journal of Biological Chemistry. 101851. PMID 35314193 DOI: 10.1016/j.jbc.2022.101851  0.346
2022 Schwer B, Garg A, Sanchez AM, Bernstein MA, Benjamin B, Shuman S. Cleavage-Polyadenylation Factor Cft1 and SPX Domain Proteins Are Agents of Inositol Pyrophosphate Toxicosis in Fission Yeast. Mbio. e0347621. PMID 35012333 DOI: 10.1128/mbio.03476-21  0.381
2021 Garg A, Shuman S, Schwer B. Genetic screen for suppression of transcriptional interference reveals fission yeast 14-3-3 protein Rad24 as an antagonist of precocious Pol2 transcription termination. Nucleic Acids Research. PMID 34967420 DOI: 10.1093/nar/gkab1263  0.311
2021 Warren GM, Meir A, Wang J, Patel DJ, Greene EC, Shuman S. Structure-activity relationships at a nucleobase-stacking tryptophan required for chemomechanical coupling in the DNA resecting motor-nuclease AdnAB. Nucleic Acids Research. PMID 34967418 DOI: 10.1093/nar/gkab1270  0.392
2021 Schwer B, Garg A, Jacewicz A, Shuman S. Genetic screen for suppression of transcriptional interference identifies a gain-of-function mutation in Pol2 termination factor Seb1. Proceedings of the National Academy of Sciences of the United States of America. 118. PMID 34389684 DOI: 10.1073/pnas.2108105118  0.325
2021 Unciuleac MC, Ghosh S, de la Cruz MJ, Goldgur Y, Shuman S. Structure and mechanism of polynucleotide phosphorylase. Rna (New York, N.Y.). PMID 34088850 DOI: 10.1261/rna.078822.121  0.419
2021 Alphonse S, Banerjee A, Dantuluri S, Shuman S, Ghose R. NMR solution structures of Runella slithyformis RNA 2'-phosphotransferase Tpt1 provide insights into NAD+ binding and specificity. Nucleic Acids Research. PMID 33880546 DOI: 10.1093/nar/gkab241  0.357
2021 Unciuleac MC, Meir A, Xue C, Warren GM, Greene EC, Shuman S. Clutch mechanism of chemomechanical coupling in a DNA resecting motor nuclease. Proceedings of the National Academy of Sciences of the United States of America. 118. PMID 33836607 DOI: 10.1073/pnas.2023955118  0.375
2021 Warren GM, Wang J, Patel DJ, Shuman S. Oligomeric quaternary structure of Escherichia coli and Mycobacterium smegmatis Lhr helicases is nucleated by a novel C-terminal domain composed of five winged-helix modules. Nucleic Acids Research. PMID 33744958 DOI: 10.1093/nar/gkab145  0.393
2021 Benjamin B, Sanchez AM, Garg A, Schwer B, Shuman S. Structure-function analysis of fission yeast cleavage and polyadenylation factor (CPF) subunit Ppn1 and its interactions with Dis2 and Swd22. Plos Genetics. 17: e1009452. PMID 33711009 DOI: 10.1371/journal.pgen.1009452  0.351
2021 Banerjee A, Goldgur Y, Shuman S. Structure of 3'-PO/5'-OH RNA ligase RtcB in complex with a 5'-OH oligonucleotide. Rna (New York, N.Y.). PMID 33619169 DOI: 10.1261/rna.078692.121  0.438
2021 Garg A, Sanchez AM, Schwer B, Shuman S. Transcriptional profiling of fission yeast RNA polymerase II CTD mutants. Rna (New York, N.Y.). PMID 33579781 DOI: 10.1261/rna.078682.121  0.341
2021 Dantuluri S, Schwer B, Abdullahu L, Damha MJ, Shuman S. Activity and substrate specificity of , , and Tpt1: essential tRNA splicing enzymes and potential anti-fungal targets. Rna (New York, N.Y.). PMID 33509912 DOI: 10.1261/rna.078660.120  0.414
2020 Ghosh S, Ejaz A, Repeta L, Shuman S. Pseudomonas putida MPE, a manganese-dependent endonuclease of the binuclear metallophosphoesterase superfamily, incises single-strand DNA in two orientations to yield a mixture of 3'-PO4 and 3'-OH termini. Nucleic Acids Research. PMID 33367848 DOI: 10.1093/nar/gkaa1214  0.399
2020 Shuman S. Transcriptional interference at tandem lncRNA and protein-coding genes: an emerging theme in regulation of cellular nutrient homeostasis. Nucleic Acids Research. PMID 32720681 DOI: 10.1093/Nar/Gkaa630  0.34
2020 Schwer B, Sanchez AM, Shuman S. Inactivation of fission yeast Erh1 de-represses expression: evidence that Erh1 is a negative regulator of lncRNA termination. Rna (New York, N.Y.). PMID 32546512 DOI: 10.1261/Rna.076463.120  0.464
2020 Unciuleac MC, Goldgur Y, Shuman S. Caveat mutator: alanine substitutions for conserved amino acids in RNA ligase elicit unexpected rearrangements of the active site for lysine adenylylation. Nucleic Acids Research. PMID 32315072 DOI: 10.1093/Nar/Gkaa238  0.497
2020 Sanchez AM, Garg A, Shuman S, Schwer B. Genetic interactions and transcriptomics implicate fission yeast CTD prolyl isomerase Pin1 as an agent of RNA 3' processing and transcription termination that functions via its effects on CTD phosphatase Ssu72. Nucleic Acids Research. PMID 32282918 DOI: 10.1093/Nar/Gkaa212  0.401
2020 Ghosh S, Goldgur Y, Shuman S. Mycobacterial DNA polymerase I: activities and crystal structures of the POL domain as apoenzyme and in complex with a DNA primer-template and of the full-length FEN/EXO-POL enzyme. Nucleic Acids Research. PMID 32034423 DOI: 10.1093/Nar/Gkaa075  0.57
2020 Dantuluri S, Abdullahu L, Munir A, Katolik A, Damha MJ, Shuman S. Substrate analogs that trap the 2'-phospho-ADP-ribosylated RNA intermediate of the Tpt1 (tRNA 2'-phosphotransferase) reaction pathway. Rna (New York, N.Y.). PMID 31932322 DOI: 10.1261/Rna.074377.119  0.462
2019 Jia N, Unciuleac MC, Xue C, Greene EC, Patel DJ, Shuman S. Structures and single-molecule analysis of bacterial motor nuclease AdnAB illuminate the mechanism of DNA double-strand break resection. Proceedings of the National Academy of Sciences of the United States of America. PMID 31740608 DOI: 10.1073/pnas.1913546116  0.481
2019 Banerjee A, Goldgur Y, Schwer B, Shuman S. Atomic structures of the RNA end-healing 5'-OH kinase and 2',3'-cyclic phosphodiesterase domains of fungal tRNA ligase: conformational switches in the kinase upon binding of the GTP phosphate donor. Nucleic Acids Research. PMID 31722405 DOI: 10.1093/Nar/Gkz1049  0.489
2019 Moldovan JB, Wang Y, Shuman S, Mills RE, Moran JV. RNA ligation precedes the retrotransposition of U6/LINE-1 chimeric RNA. Proceedings of the National Academy of Sciences of the United States of America. PMID 31548405 DOI: 10.1073/Pnas.1805404116  0.376
2019 Sanchez AM, Garg A, Shuman S, Schwer B. Inositol pyrophosphates impact phosphate homeostasis via modulation of RNA 3' processing and transcription termination. Nucleic Acids Research. PMID 31276588 DOI: 10.1093/Nar/Gkz567  0.397
2019 Munir A, Shuman S. Structure-function analysis of the phosphoesterase component of the nucleic acid end-healing enzyme HD-Pnk. Journal of Bacteriology. PMID 31160396 DOI: 10.1128/Jb.00292-19  0.506
2019 Munir A, Abdullahu L, Banerjee A, Damha MJ, Shuman S. NAD-dependent RNA terminal 2' and 3' phosphomonoesterase activity of a sub-set of Tpt1 enzymes. Rna (New York, N.Y.). PMID 31019096 DOI: 10.1261/Rna.071142.119  0.496
2019 Garg A, Goldgur Y, Sanchez AM, Schwer B, Shuman S. Structure of fission yeast transcription factor Pho7 bound to promoter DNA and effect of Pho7 mutations on DNA binding and phosphate homeostasis. Molecular and Cellular Biology. PMID 31010807 DOI: 10.1128/Mcb.00132-19  0.468
2019 Ejaz A, Goldgur Y, Shuman S. Activity and structure of MPE, a manganese-dependent single-strand DNA endonuclease encoded in a nucleic acid repair gene cluster. The Journal of Biological Chemistry. PMID 30894417 DOI: 10.1074/Jbc.Ra119.008049  0.527
2019 Unciuleac MC, Goldgur Y, Shuman S. Structures of ATP-bound DNA ligase D in a closed domain conformation reveal a network of amino acid and metal contacts to the ATP phosphates. The Journal of Biological Chemistry. PMID 30718283 DOI: 10.1074/Jbc.Ra119.007445  0.505
2019 Banerjee A, Munir A, Abdullahu L, Damha MJ, Goldgur Y, Shuman S. Structure of tRNA splicing enzyme Tpt1 illuminates the mechanism of RNA 2'-PO recognition and ADP-ribosylation. Nature Communications. 10: 218. PMID 30644400 DOI: 10.1038/s41467-018-08211-9  0.477
2018 Banerjee A, Ghosh S, Goldgur Y, Shuman S. Structure and two-metal mechanism of fungal tRNA ligase. Nucleic Acids Research. PMID 30590734 DOI: 10.1093/nar/gky1275  0.495
2018 Agarwal R, Schwer B, Shuman S. Domain Requirements and Genetic Interactions of the Mud1 Subunit of the U1 snRNP. G3 (Bethesda, Md.). PMID 30413416 DOI: 10.1534/G3.118.200781  0.414
2018 Sanchez AM, Shuman S, Schwer B. RNA polymerase II CTD interactome with 3' processing and termination factors in fission yeast and its impact on phosphate homeostasis. Proceedings of the National Academy of Sciences of the United States of America. PMID 30355770 DOI: 10.1073/Pnas.1810711115  0.445
2018 Ejaz A, Shuman S. Characterization of Lhr-Core DNA helicase and Mn-dependent DNA nuclease components of a bacterial gene cluster encoding nucleic acid repair enzymes. The Journal of Biological Chemistry. PMID 30224353 DOI: 10.1074/Jbc.Ra118.005296  0.506
2018 Garg A, Goldgur Y, Schwer B, Shuman S. Distinctive structural basis for DNA recognition by the fission yeast Zn2Cys6 transcription factor Pho7 and its role in phosphate homeostasis. Nucleic Acids Research. PMID 30212894 DOI: 10.1093/nar/gky827  0.442
2018 Munir A, Banerjee A, Shuman S. NAD+-dependent synthesis of a 5'-phospho-ADP-ribosylated RNA/DNA cap by RNA 2'-phosphotransferase Tpt1. Nucleic Acids Research. PMID 30202863 DOI: 10.1093/Nar/Gky792  0.495
2018 Schmier BJ, Shuman S. HD-Pnk, a nucleic acid end-healing enzyme, abets resistance to killing by ionizing radiation and mitomycin C. Journal of Bacteriology. PMID 29891641 DOI: 10.1128/Jb.00151-18  0.461
2018 Munir A, Abdullahu L, Damha M, Shuman S. Two-step mechanism and step-arrest mutants of Runella slithyformis NAD-dependent tRNA 2'-phosphotransferase Tpt1. Rna (New York, N.Y.). PMID 29884622 DOI: 10.1261/Rna.067165.118  0.438
2018 Uson ML, Carl A, Goldgur Y, Shuman S. Crystal structure and mutational analysis of Mycobacterium smegmatis FenA highlight active site amino acids and three metal ions essential for flap endonuclease and 5' exonuclease activities. Nucleic Acids Research. PMID 29635474 DOI: 10.1093/nar/gky238  0.389
2018 Roth AJ, Shuman S, Schwer B. Defining essential elements and genetic interactions of the yeast Lsm2-8 ring and demonstration that essentiality of Lsm2-8 is bypassed via overexpression of U6 snRNA or the U6 snRNP subunit Prp24. Rna (New York, N.Y.). PMID 29615482 DOI: 10.1261/Rna.066175.118  0.407
2018 Garg A, Sanchez AM, Shuman S, Schwer B. A long noncoding (lnc) RNA governs expression of the phosphate transporter Pho84 in fission yeast and has cascading effects on the flanking prt lncRNA and pho1 genes. The Journal of Biological Chemistry. PMID 29414789 DOI: 10.1074/Jbc.Ra117.001352  0.342
2017 Remus BS, Goldgur Y, Shuman S. Structural basis for the GTP specificity of the RNA kinase domain of fungal tRNA ligase. Nucleic Acids Research. PMID 29165709 DOI: 10.1093/Nar/Gkx1159  0.512
2017 Ejaz A, Ordonez H, Jacewicz A, Ferrao R, Shuman S. Structure of mycobacterial 3'-to-5' RNA:DNA helicase Lhr bound to a ssDNA tracking strand highlights distinctive features of a novel family of bacterial helicases. Nucleic Acids Research. PMID 29165676 DOI: 10.1093/Nar/Gkx1163  0.553
2017 Sanchez AM, Shuman S, Schwer B. Poly(A) site choice and Pol2 CTD Serine-5 status govern lncRNA control of phosphate-responsive tgp1 gene expression in fission yeast. Rna (New York, N.Y.). PMID 29122971 DOI: 10.1261/Rna.063966.117  0.412
2017 Schwer B, Sanchez AM, Garg A, Chatterjee D, Shuman S. Defining the DNA Binding Site Recognized by the Fission Yeast Zn2Cys6 Transcription Factor Pho7 and Its Role in Phosphate Homeostasis. Mbio. 8. PMID 28811350 DOI: 10.1128/Mbio.01218-17  0.44
2017 Uson ML, Ghosh S, Shuman S. The DNA repair repertoire of Mycobacterium smegmatis FenA includes the incision of DNA 5' flaps and the removal of 5' adenylylated products of aborted nick ligation. Journal of Bacteriology. PMID 28630124 DOI: 10.1128/Jb.00304-17  0.481
2017 Reed BR, Yakovleva L, Shuman S, Ghose R. Characterization of DNA binding by the isolated N-terminal domain of vaccinia virus DNA topoisomerase IB. Biochemistry. PMID 28570045 DOI: 10.1021/Acs.Biochem.7B00042  0.501
2017 Unciuleac MC, Goldgur Y, Shuman S. Two-metal versus one-metal mechanisms of lysine adenylylation by ATP-dependent and NAD(+)-dependent polynucleotide ligases. Proceedings of the National Academy of Sciences of the United States of America. PMID 28223499 DOI: 10.1073/Pnas.1619220114  0.441
2017 Schmier BJ, Chen X, Wolin S, Shuman S. Deletion of the rnl gene encoding a nick-sealing RNA ligase sensitizes Deinococcus radiodurans to ionizing radiation. Nucleic Acids Research. PMID 28126918 DOI: 10.1093/Nar/Gkx038  0.406
2016 Schwer B, Roth AJ, Shuman S. Will the circle be unbroken: specific mutations in the yeast Sm protein ring expose a requirement for assembly factor Brr1, a homolog of Gemin2. Rna (New York, N.Y.). PMID 27974620 DOI: 10.1261/Rna.059881.116  0.421
2016 Gupta R, Unciuleac MC, Shuman S, Glickman MS. Homologous recombination mediated by the mycobacterial AdnAB helicase without end resection by the AdnAB nucleases. Nucleic Acids Research. PMID 27899634 DOI: 10.1093/Nar/Gkw1130  0.666
2016 Gupta R, Chatterjee D, Glickman MS, Shuman S. Division of labor among Mycobacterium smegmatis RNase H enzymes: RNase H1 activity of RnhA or RnhC is essential for growth whereas RnhB and RnhA guard against killing by hydrogen peroxide in stationary phase. Nucleic Acids Research. PMID 27899559 DOI: 10.1093/Nar/Gkw1046  0.609
2016 Munir A, Shuman S. Characterization of Runella slithyformis HD-Pnk, a bifunctional DNA/RNA end-healing enzyme composed of an N-terminal 2',3' -phosphoesterase HD domain and a C-terminal 5' -OH polynucleotide kinase domain. Journal of Bacteriology. PMID 27895092 DOI: 10.1128/Jb.00739-16  0.54
2016 Schwer B, Khalid F, Shuman S. Mechanistic insights into the manganese-dependent phosphodiesterase activity of yeast Dbr1 with bis-p-nitrophenylphosphate and branched RNA substrates. Rna (New York, N.Y.). PMID 27765821 DOI: 10.1261/Rna.058552.116  0.494
2016 Remus BS, Schwer B, Shuman S. Characterization of the tRNA ligases of pathogenic fungi Aspergillus fumigatus and Coccidioides immitis. Rna (New York, N.Y.). PMID 27492257 DOI: 10.1261/Rna.057455.116  0.496
2016 Schwer B, Kruchten J, Shuman S. Structure-function analysis and genetic interactions of the SmG, SmE, and SmF subunits of the yeast Sm protein ring. Rna (New York, N.Y.). PMID 27417296 DOI: 10.1261/Rna.057448.116  0.453
2016 Inada M, Nichols RJ, Parsa JY, Homer CM, Benn RA, Hoxie RS, Madhani HD, Shuman S, Schwer B, Pleiss JA. Phospho-site mutants of the RNA Polymerase II C-terminal domain alter subtelomeric gene expression and chromatin modification state in fission yeast. Nucleic Acids Research. PMID 27402158 DOI: 10.1093/Nar/Gkw603  0.425
2016 Agarwal R, Schwer B, Shuman S. Structure-function analysis and genetic interactions of the Luc7 subunit of the Saccharomyces cerevisiae U1 snRNP. Rna (New York, N.Y.). PMID 27354704 DOI: 10.1261/Rna.056911.116  0.42
2016 Cho JE, Huang SN, Burgers PM, Shuman S, Pommier Y, Jinks-Robertson S. Parallel analysis of ribonucleotide-dependent deletions produced by yeast Top1 in vitro and in vivo. Nucleic Acids Research. PMID 27257064 DOI: 10.1093/Nar/Gkw495  0.445
2016 Chatterjee D, Sanchez AM, Goldgur Y, Shuman S, Schwer B. Transcription of lncRNA prt, clustered prt RNA sites for Mmi1 binding, and RNA polymerase II CTD phospho-sites govern the repression of pho1 gene expression under phosphate-replete conditions in fission yeast. Rna (New York, N.Y.). PMID 27165520 DOI: 10.1261/Rna.056515.116  0.492
2016 Unciuleac MC, Smith PC, Shuman S. Crystal structure and biochemical characterization of a Mycobacterium smegmatis AAA-type nucleoside triphosphatase phosphohydrolase (Msm0858). Journal of Bacteriology. PMID 26953339 DOI: 10.1128/Jb.00905-15  0.436
2016 Maughan WP, Shuman S. Distinct contributions of enzymic functional groups to the 2',3' -cyclic phosphodiesterase, 3' -phosphate guanylylation, and 3' -ppG/5' -OH ligation steps of the Escherichia coli RtcB nucleic acid splicing pathway. Journal of Bacteriology. PMID 26858100 DOI: 10.1128/Jb.00913-15  0.516
2016 Chauleau M, Shuman S. Kinetic mechanism and fidelity of nick sealing by Escherichia coli NAD+-dependent DNA ligase (LigA). Nucleic Acids Research. PMID 26857547 DOI: 10.1093/Nar/Gkw049  0.457
2015 Smith P, Ho CK, Takagi Y, Djaballah H, Shuman S. Nanomolar Inhibitors of Trypanosoma brucei RNA Triphosphatase. Mbio. 7. PMID 26908574 DOI: 10.1128/Mbio.00058-16  0.423
2015 Unciuleac MC, Goldgur Y, Shuman S. Structure and two-metal mechanism of a eukaryal nick-sealing RNA ligase. Proceedings of the National Academy of Sciences of the United States of America. 112: 13868-73. PMID 26512110 DOI: 10.1073/Pnas.1516536112  0.5
2015 Maughan WP, Shuman S. Characterization of 3'-Phosphate RNA Ligase Paralogs RtcB1, RtcB2, and RtcB3 from Myxococcus xanthus Highlights DNA and RNA 5'-Phosphate Capping Activity of RtcB3. Journal of Bacteriology. 197: 3616-24. PMID 26350128 DOI: 10.1128/Jb.00631-15  0.54
2015 Mbogning J, Pagé V, Burston J, Schwenger E, Fisher RP, Schwer B, Shuman S, Tanny JC. Functional interaction of Rpb1 and Spt5 C-terminal domains in co-transcriptional histone modification. Nucleic Acids Research. PMID 26275777 DOI: 10.1093/Nar/Gkv837  0.375
2015 Schwer B, Sanchez AM, Shuman S. RNA polymerase II CTD phospho-sites Ser5 and Ser7 govern phosphate homeostasis in fission yeast. Rna (New York, N.Y.). 21: 1770-80. PMID 26264592 DOI: 10.1261/Rna.052555.115  0.431
2015 Gupta R, Shuman S, Glickman MS. RecF and RecR Play Critical Roles in the Homologous Recombination and Single-Strand Annealing Pathways of Mycobacteria. Journal of Bacteriology. 197: 3121-32. PMID 26195593 DOI: 10.1128/Jb.00290-15  0.618
2015 Uson ML, Ordonez H, Shuman S. Mycobacterium smegmatis HelY Is an RNA-Activated ATPase/dATPase and 3'-to-5' Helicase That Unwinds 3'-Tailed RNA Duplexes and RNA:DNA Hybrids. Journal of Bacteriology. 197: 3057-65. PMID 26170411 DOI: 10.1128/Jb.00418-15  0.499
2015 Chauleau M, Jacewicz A, Shuman S. DNA3'pp5'G de-capping activity of aprataxin: effect of cap nucleoside analogs and structural basis for guanosine recognition. Nucleic Acids Research. PMID 26007660 DOI: 10.1093/Nar/Gkv501  0.505
2015 Jacewicz A, Shuman S. Biochemical characterization of Mycobacterium smegmatis RnhC (MSMEG_4305), a bifunctional enzyme composed of autonomous N-terminal type I ribonuclease H and C-terminal acid phosphatase domains. Journal of Bacteriology. PMID 25986906 DOI: 10.1128/Jb.00268-15  0.546
2015 Qiu ZR, Schwer B, Shuman S. Two Routes to Genetic Suppression of RNA Trimethylguanosine Cap Deficiency, via C-terminal Truncation of U1 snRNP Subunit Snp1 or Overexpression of RNA Polymerase Subunit Rpo26. G3 (Bethesda, Md.). PMID 25911228 DOI: 10.1534/G3.115.016675  0.645
2015 Schwer B, Shuman S. Structure-function analysis and genetic interactions of the Yhc1, SmD3, SmB, and Snp1 subunits of yeast U1 snRNP and genetic interactions of SmD3 with U2 snRNP subunit Lea1. Rna (New York, N.Y.). 21: 1173-86. PMID 25897024 DOI: 10.1261/Rna.050583.115  0.428
2015 Schwer B, Ghosh A, Sanchez AM, Lima CD, Shuman S. Genetic and structural analysis of the essential fission yeast RNA polymerase II CTD phosphatase Fcp1. Rna (New York, N.Y.). 21: 1135-46. PMID 25883047 DOI: 10.1261/Rna.050286.115  0.493
2015 Shuman S. RNA capping: progress and prospects. Rna (New York, N.Y.). 21: 735-7. PMID 25780214 DOI: 10.1261/Rna.049973.115  0.456
2015 Chauleau M, Das U, Shuman S. Effects of DNA3'pp5'G capping on 3' end repair reactions and of an embedded pyrophosphate-linked guanylate on ribonucleotide surveillance. Nucleic Acids Research. 43: 3197-207. PMID 25753667 DOI: 10.1093/Nar/Gkv179  0.454
2015 Unciuleac MC, Shuman S. Characterization of a novel eukaryal nick-sealing RNA ligase from Naegleria gruberi. Rna (New York, N.Y.). 21: 824-32. PMID 25740837 DOI: 10.1261/Rna.049197.114  0.498
2015 Jacewicz A, Chico L, Smith P, Schwer B, Shuman S. Structural basis for recognition of intron branchpoint RNA by yeast Msl5 and selective effects of interfacial mutations on splicing of yeast pre-mRNAs. Rna (New York, N.Y.). 21: 401-14. PMID 25587180 DOI: 10.1261/Rna.048942.114  0.461
2015 Doamekpor SK, Schwer B, Sanchez AM, Shuman S, Lima CD. Fission yeast RNA triphosphatase reads an Spt5 CTD code. Rna (New York, N.Y.). 21: 113-23. PMID 25414009 DOI: 10.1261/Rna.048181.114  0.476
2014 Ordonez H, Shuman S. Mycobacterium smegmatis DinB2 misincorporates deoxyribonucleotides and ribonucleotides during templated synthesis and lesion bypass. Nucleic Acids Research. 42: 12722-34. PMID 25352547 DOI: 10.1093/Nar/Gku1027  0.49
2014 Jacewicz A, Schwer B, Smith P, Shuman S. Crystal structure, mutational analysis and RNA-dependent ATPase activity of the yeast DEAD-box pre-mRNA splicing factor Prp28. Nucleic Acids Research. 42: 12885-98. PMID 25303995 DOI: 10.1093/Nar/Gku930  0.522
2014 Das U, Wang LK, Smith P, Munir A, Shuman S. Structures of bacterial polynucleotide kinase in a michaelis complex with nucleoside triphosphate (NTP)-Mg2+ and 5'-OH RNA and a mixed substrate-product complex with NTP-Mg2+ and a 5'-phosphorylated oligonucleotide. Journal of Bacteriology. 196: 4285-92. PMID 25266383 DOI: 10.1128/Jb.02197-14  0.509
2014 Remus BS, Jacewicz A, Shuman S. Structure and mechanism of E. coli RNA 2',3'-cyclic phosphodiesterase. Rna (New York, N.Y.). 20: 1697-705. PMID 25239919 DOI: 10.1261/Rna.046797.114  0.504
2014 Ordonez H, Uson ML, Shuman S. Characterization of three mycobacterial DinB (DNA polymerase IV) paralogs highlights DinB2 as naturally adept at ribonucleotide incorporation. Nucleic Acids Research. 42: 11056-70. PMID 25200080 DOI: 10.1093/Nar/Gku752  0.466
2014 Das U, Chauleau M, Ordonez H, Shuman S. Impact of DNA3'pp5'G capping on repair reactions at DNA 3' ends. Proceedings of the National Academy of Sciences of the United States of America. 111: 11317-22. PMID 25049385 DOI: 10.1073/Pnas.1409203111  0.451
2014 Doamekpor SK, Sanchez AM, Schwer B, Shuman S, Lima CD. How an mRNA capping enzyme reads distinct RNA polymerase II and Spt5 CTD phosphorylation codes. Genes & Development. 28: 1323-36. PMID 24939935 DOI: 10.1101/Gad.242768.114  0.509
2014 Dai P, Wang W, Cao H, Avogadri F, Dai L, Drexler I, Joyce JA, Li XD, Chen Z, Merghoub T, Shuman S, Deng L. Modified vaccinia virus Ankara triggers type I IFN production in murine conventional dendritic cells via a cGAS/STING-mediated cytosolic DNA-sensing pathway. Plos Pathogens. 10: e1003989. PMID 24743339 DOI: 10.1371/Journal.Ppat.1003989  0.326
2014 Chakravarty AK, Smith P, Jalan R, Shuman S. Structure, mechanism, and specificity of a eukaryal tRNA restriction enzyme involved in self-nonself discrimination. Cell Reports. 7: 339-47. PMID 24726365 DOI: 10.1016/J.Celrep.2014.03.034  0.435
2014 Kyrieleis OJ, Chang J, de la Peña M, Shuman S, Cusack S. Crystal structure of vaccinia virus mRNA capping enzyme provides insights into the mechanism and evolution of the capping apparatus. Structure (London, England : 1993). 22: 452-65. PMID 24607143 DOI: 10.1016/J.Str.2013.12.014  0.482
2014 Schwer B, Bitton DA, Sanchez AM, Bähler J, Shuman S. Individual letters of the RNA polymerase II CTD code govern distinct gene expression programs in fission yeast. Proceedings of the National Academy of Sciences of the United States of America. 111: 4185-90. PMID 24591591 DOI: 10.1073/Pnas.1321842111  0.393
2014 Remus BS, Shuman S. Distinctive kinetics and substrate specificities of plant and fungal tRNA ligases. Rna (New York, N.Y.). 20: 462-73. PMID 24554441 DOI: 10.1261/Rna.043752.113  0.478
2014 Schmier BJ, Shuman S. Effects of 3'-OH and 5'-PO4 base mispairs and damaged base lesions on the fidelity of nick sealing by Deinococcus radiodurans RNA ligase. Journal of Bacteriology. 196: 1704-12. PMID 24532777 DOI: 10.1128/Jb.00020-14  0.424
2014 Schwer B, Shuman S. Structure-function analysis of the Yhc1 subunit of yeast U1 snRNP and genetic interactions of Yhc1 with Mud2, Nam8, Mud1, Tgs1, U1 snRNA, SmD3 and Prp28. Nucleic Acids Research. 42: 4697-711. PMID 24497193 DOI: 10.1093/Nar/Gku097  0.409
2014 Das U, Wang LK, Smith P, Jacewicz A, Shuman S. Structures of bacterial polynucleotide kinase in a Michaelis complex with GTP•Mg2+ and 5'-OH oligonucleotide and a product complex with GDP•Mg2+ and 5'-PO4 oligonucleotide reveal a mechanism of general acid-base catalysis and the determinants of phosphoacceptor recognition. Nucleic Acids Research. 42: 1152-61. PMID 24150947 DOI: 10.1093/Nar/Gkt936  0.394
2013 Mbogning J, Nagy S, Pagé V, Schwer B, Shuman S, Fisher RP, Tanny JC. The PAF complex and Prf1/Rtf1 delineate distinct Cdk9-dependent pathways regulating transcription elongation in fission yeast. Plos Genetics. 9: e1004029. PMID 24385927 DOI: 10.1371/Journal.Pgen.1004029  0.365
2013 Das U, Chakravarty AK, Remus BS, Shuman S. Rewriting the rules for end joining via enzymatic splicing of DNA 3'-PO4 and 5'-OH ends. Proceedings of the National Academy of Sciences of the United States of America. 110: 20437-42. PMID 24218597 DOI: 10.1073/Pnas.1314289110  0.451
2013 Chauleau M, Shuman S. Kinetic mechanism of nick sealing by T4 RNA ligase 2 and effects of 3'-OH base mispairs and damaged base lesions. Rna (New York, N.Y.). 19: 1840-7. PMID 24158792 DOI: 10.1261/Rna.041731.113  0.476
2013 Unciuleac MC, Shuman S. Discrimination of RNA from DNA by polynucleotide phosphorylase. Biochemistry. 52: 6702-11. PMID 23980617 DOI: 10.1021/Bi401041V  0.513
2013 Das U, Shuman S. 2'-Phosphate cyclase activity of RtcA: a potential rationale for the operon organization of RtcA with an RNA repair ligase RtcB in Escherichia coli and other bacterial taxa. Rna (New York, N.Y.). 19: 1355-62. PMID 23945037 DOI: 10.1261/Rna.039917.113  0.458
2013 Gao P, Ascano M, Zillinger T, Wang W, Dai P, Serganov AA, Gaffney BL, Shuman S, Jones RA, Deng L, Hartmann G, Barchet W, Tuschl T, Patel DJ. Structure-function analysis of STING activation by c[G(2',5')pA(3',5')p] and targeting by antiviral DMXAA. Cell. 154: 748-62. PMID 23910378 DOI: 10.1016/J.Cell.2013.07.023  0.329
2013 Schwer B, Chang J, Shuman S. Structure-function analysis of the 5' end of yeast U1 snRNA highlights genetic interactions with the Msl5*Mud2 branchpoint-binding complex and other spliceosome assembly factors. Nucleic Acids Research. 41: 7485-500. PMID 23754852 DOI: 10.1093/Nar/Gkt490  0.395
2013 Das U, Wang LK, Smith P, Shuman S. Structural and biochemical analysis of the phosphate donor specificity of the polynucleotide kinase component of the bacterial pnkp•hen1 RNA repair system. Biochemistry. 52: 4734-43. PMID 23721485 DOI: 10.1021/Bi400412X  0.484
2013 Wang LK, Smith P, Shuman S. Structure and mechanism of the 2',3' phosphatase component of the bacterial Pnkp-Hen1 RNA repair system. Nucleic Acids Research. 41: 5864-73. PMID 23595150 DOI: 10.1093/Nar/Gkt221  0.514
2013 Unciuleac MC, Shuman S. Distinctive effects of domain deletions on the manganese-dependent DNA polymerase and DNA phosphorylase activities of Mycobacterium smegmatis polynucleotide phosphorylase. Biochemistry. 52: 2967-81. PMID 23560592 DOI: 10.1021/Bi400281W  0.582
2013 Ordonez H, Shuman S. Mycobacterium smegmatis Lhr Is a DNA-dependent ATPase and a 3'-to-5' DNA translocase and helicase that prefers to unwind 3'-tailed RNA:DNA hybrids. The Journal of Biological Chemistry. 288: 14125-34. PMID 23549043 DOI: 10.1074/Jbc.M113.466854  0.531
2013 Remus BS, Shuman S. A kinetic framework for tRNA ligase and enforcement of a 2'-phosphate requirement for ligation highlights the design logic of an RNA repair machine. Rna (New York, N.Y.). 19: 659-69. PMID 23515942 DOI: 10.1261/Rna.038406.113  0.496
2013 Yakovleva L, Shuman S. Chemical mutagenesis of vaccinia DNA topoisomerase lysine 167 provides insights to the catalysis of DNA transesterification. Biochemistry. 52: 984-91. PMID 23317114 DOI: 10.1021/Bi301643H  0.425
2013 Gupta R, Ryzhikov M, Koroleva O, Unciuleac M, Shuman S, Korolev S, Glickman MS. A dual role for mycobacterial RecO in RecA-dependent homologous recombination and RecA-independent single-strand annealing. Nucleic Acids Research. 41: 2284-95. PMID 23295671 DOI: 10.1093/Nar/Gks1298  0.582
2013 Das U, Shuman S. Mechanism of RNA 2',3'-cyclic phosphate end healing by T4 polynucleotide kinase-phosphatase. Nucleic Acids Research. 41: 355-65. PMID 23118482 DOI: 10.1093/Nar/Gks977  0.469
2012 Zhu H, Bhattarai H, Yan HG, Shuman S, Glickman MS. Characterization of Mycobacterium smegmatis PolD2 and PolD1 as RNA/DNA polymerases homologous to the POL domain of bacterial DNA ligase D. Biochemistry. 51: 10147-58. PMID 23198659 DOI: 10.1021/Bi301202E  0.697
2012 Wang LK, Das U, Smith P, Shuman S. Structure and mechanism of the polynucleotide kinase component of the bacterial Pnkp-Hen1 RNA repair system. Rna (New York, N.Y.). 18: 2277-86. PMID 23118415 DOI: 10.1261/Rna.036061.112  0.487
2012 Schwer B, Sanchez AM, Shuman S. Punctuation and syntax of the RNA polymerase II CTD code in fission yeast. Proceedings of the National Academy of Sciences of the United States of America. 109: 18024-9. PMID 23071310 DOI: 10.1073/Pnas.1208995109  0.344
2012 Qiu ZR, Chico L, Chang J, Shuman S, Schwer B. Genetic interactions of hypomorphic mutations in the m7G cap-binding pocket of yeast nuclear cap binding complex: an essential role for Cbc2 in meiosis via splicing of MER3 pre-mRNA. Rna (New York, N.Y.). 18: 1996-2011. PMID 23002122 DOI: 10.1261/Rna.033746.112  0.578
2012 Simoes-Barbosa A, Chakrabarti K, Pearson M, Benarroch D, Shuman S, Johnson PJ. Box H/ACA snoRNAs are preferred substrates for the trimethylguanosine synthase in the divergent unicellular eukaryote Trichomonas vaginalis. Rna (New York, N.Y.). 18: 1656-65. PMID 22847815 DOI: 10.1261/Rna.034249.112  0.319
2012 Meineke B, Kast A, Schwer B, Meinhardt F, Shuman S, Klassen R. A fungal anticodon nuclease ribotoxin exploits a secondary cleavage site to evade tRNA repair. Rna (New York, N.Y.). 18: 1716-24. PMID 22836353 DOI: 10.1261/Rna.034132.112  0.485
2012 Samai P, Shuman S. Kinetic analysis of DNA strand joining by Chlorella virus DNA ligase and the role of nucleotidyltransferase motif VI in ligase adenylylation. The Journal of Biological Chemistry. 287: 28609-18. PMID 22745124 DOI: 10.1074/Jbc.M112.380428  0.828
2012 Chakravarty AK, Shuman S. The sequential 2',3'-cyclic phosphodiesterase and 3'-phosphate/5'-OH ligation steps of the RtcB RNA splicing pathway are GTP-dependent. Nucleic Acids Research. 40: 8558-67. PMID 22730297 DOI: 10.1093/Nar/Gks558  0.445
2012 Yakovleva L, Shuman S. Mycobacterium smegmatis SftH exemplifies a distinctive clade of superfamily II DNA-dependent ATPases with 3' to 5' translocase and helicase activities. Nucleic Acids Research. 40: 7465-75. PMID 22641846 DOI: 10.1093/Nar/Gks417  0.503
2012 Cao H, Dai P, Wang W, Li H, Yuan J, Wang F, Fang CM, Pitha PM, Liu J, Condit RC, McFadden G, Merghoub T, Houghton AN, Young JW, Shuman S, et al. Innate immune response of human plasmacytoid dendritic cells to poxvirus infection is subverted by vaccinia E3 via its Z-DNA/RNA binding domain. Plos One. 7: e36823. PMID 22606294 DOI: 10.1371/Journal.Pone.0036823  0.377
2012 Chakravarty AK, Subbotin R, Chait BT, Shuman S. RNA ligase RtcB splices 3'-phosphate and 5'-OH ends via covalent RtcB-(histidinyl)-GMP and polynucleotide-(3')pp(5')G intermediates. Proceedings of the National Academy of Sciences of the United States of America. 109: 6072-7. PMID 22474365 DOI: 10.1073/Pnas.1201207109  0.501
2012 Meineke B, Shuman S. Structure-function relations in the NTPase domain of the antiviral tRNA ribotoxin Escherichia coli PrrC. Virology. 427: 144-50. PMID 22386822 DOI: 10.1016/J.Virol.2012.02.008  0.417
2012 Smith P, Wang LK, Nair PA, Shuman S. The adenylyltransferase domain of bacterial Pnkp defines a unique RNA ligase family. Proceedings of the National Academy of Sciences of the United States of America. 109: 2296-301. PMID 22308407 DOI: 10.1073/Pnas.1116827109  0.5
2012 Chang J, Schwer B, Shuman S. Structure-function analysis and genetic interactions of the yeast branchpoint binding protein Msl5. Nucleic Acids Research. 40: 4539-52. PMID 22287628 DOI: 10.1093/Nar/Gks049  0.439
2012 Ordonez H, Unciuleac M, Shuman S. Mycobacterium smegmatis RqlH defines a novel clade of bacterial RecQ-like DNA helicases with ATP-dependent 3'-5' translocase and duplex unwinding activities. Nucleic Acids Research. 40: 4604-14. PMID 22287622 DOI: 10.1093/Nar/Gks046  0.489
2012 Meineke B, Shuman S. Determinants of the cytotoxicity of PrrC anticodon nuclease and its amelioration by tRNA repair. Rna (New York, N.Y.). 18: 145-54. PMID 22101242 DOI: 10.1261/Rna.030171.111  0.487
2012 Natarajan A, Dutta K, Temel DB, Nair PA, Shuman S, Ghose R. Solution structure and DNA-binding properties of the phosphoesterase domain of DNA ligase D. Nucleic Acids Research. 40: 2076-88. PMID 22084199 DOI: 10.1093/Nar/Gkr950  0.517
2012 Das U, Smith P, Shuman S. Structural insights to the metal specificity of an archaeal member of the LigD 3'-phosphoesterase DNA repair enzyme family. Nucleic Acids Research. 40: 828-36. PMID 21965539 DOI: 10.1093/Nar/Gkr767  0.412
2011 Chakravarty AK, Smith P, Shuman S. Structures of RNA 3'-phosphate cyclase bound to ATP reveal the mechanism of nucleotidyl transfer and metal-assisted catalysis. Proceedings of the National Academy of Sciences of the United States of America. 108: 21034-9. PMID 22167800 DOI: 10.1073/Pnas.1115560108  0.44
2011 Tanaka N, Chakravarty AK, Maughan B, Shuman S. Novel mechanism of RNA repair by RtcB via sequential 2',3'-cyclic phosphodiesterase and 3'-Phosphate/5'-hydroxyl ligation reactions. The Journal of Biological Chemistry. 286: 43134-43. PMID 22045815 DOI: 10.1074/Jbc.M111.302133  0.496
2011 Dai P, Cao H, Merghoub T, Avogadri F, Wang W, Parikh T, Fang CM, Pitha PM, Fitzgerald KA, Rahman MM, McFadden G, Hu X, Houghton AN, Shuman S, Deng L. Myxoma virus induces type I interferon production in murine plasmacytoid dendritic cells via a TLR9/MyD88-, IRF5/IRF7-, and IFNAR-dependent pathway. Journal of Virology. 85: 10814-25. PMID 21835795 DOI: 10.1128/Jvi.00104-11  0.336
2011 Qiu ZR, Schwer B, Shuman S. Defining the Mer1 and Nam8 meiotic splicing regulons by cDNA rescue. Rna (New York, N.Y.). 17: 1648-54. PMID 21788335 DOI: 10.1261/Rna.2792011  0.606
2011 Tanaka N, Meineke B, Shuman S. RtcB, a novel RNA ligase, can catalyze tRNA splicing and HAC1 mRNA splicing in vivo. The Journal of Biological Chemistry. 286: 30253-7. PMID 21757685 DOI: 10.1074/Jbc.C111.274597  0.496
2011 Schwer B, Shuman S. Deciphering the RNA polymerase II CTD code in fission yeast. Molecular Cell. 43: 311-8. PMID 21684186 DOI: 10.1016/J.Molcel.2011.05.024  0.44
2011 Ghosh A, Shuman S, Lima CD. Structural insights to how mammalian capping enzyme reads the CTD code. Molecular Cell. 43: 299-310. PMID 21683636 DOI: 10.1016/J.Molcel.2011.06.001  0.507
2011 Jain R, Poulos MG, Gros J, Chakravarty AK, Shuman S. Substrate specificity and mutational analysis of Kluyveromyces lactis gamma-toxin, a eukaryal tRNA anticodon nuclease. Rna (New York, N.Y.). 17: 1336-43. PMID 21610213 DOI: 10.1261/Rna.2722711  0.667
2011 Schwer B, Erdjument-Bromage H, Shuman S. Composition of yeast snRNPs and snoRNPs in the absence of trimethylguanosine caps reveals nuclear cap binding protein as a gained U1 component implicated in the cold-sensitivity of tgs1Δ cells. Nucleic Acids Research. 39: 6715-28. PMID 21558325 DOI: 10.1093/Nar/Gkr279  0.401
2011 Samai P, Shuman S. Structure-function analysis of the OB and latch domains of chlorella virus DNA ligase. The Journal of Biological Chemistry. 286: 22642-52. PMID 21527793 DOI: 10.1074/Jbc.M111.245399  0.842
2011 Qiu ZR, Shuman S, Schwer B. An essential role for trimethylguanosine RNA caps in Saccharomyces cerevisiae meiosis and their requirement for splicing of SAE3 and PCH2 meiotic pre-mRNAs. Nucleic Acids Research. 39: 5633-46. PMID 21398639 DOI: 10.1093/Nar/Gkr083  0.615
2011 Simsek D, Furda A, Gao Y, Artus J, Brunet E, Hadjantonakis AK, Van Houten B, Shuman S, McKinnon PJ, Jasin M. Crucial role for DNA ligase III in mitochondria but not in Xrcc1-dependent repair. Nature. 471: 245-8. PMID 21390132 DOI: 10.1038/Nature09794  0.463
2011 Tanaka N, Smith P, Shuman S. Crystal structure of Rcl1, an essential component of the eukaryal pre-rRNA processosome implicated in 18s rRNA biogenesis. Rna (New York, N.Y.). 17: 595-602. PMID 21367972 DOI: 10.1261/Rna.2571811  0.518
2011 Samai P, Shuman S. Functional dissection of the DNA interface of the nucleotidyltransferase domain of chlorella virus DNA ligase. The Journal of Biological Chemistry. 286: 13314-26. PMID 21335605 DOI: 10.1074/Jbc.M111.226191  0.841
2011 Tanaka N, Shuman S. RtcB is the RNA ligase component of an Escherichia coli RNA repair operon. The Journal of Biological Chemistry. 286: 7727-31. PMID 21224389 DOI: 10.1074/Jbc.C111.219022  0.469
2011 Gupta R, Barkan D, Redelman-Sidi G, Shuman S, Glickman MS. Mycobacteria exploit three genetically distinct DNA double-strand break repair pathways. Molecular Microbiology. 79: 316-30. PMID 21219454 DOI: 10.1111/J.1365-2958.2010.07463.X  0.585
2011 Dutta K, Natarajan A, Nair PA, Shuman S, Ghose R. Sequence-specific 1H, 13C and 15N assignments of the phosphoesterase (PE) domain of Pseudomonas aeruginosa DNA ligase D (LigD). Biomolecular Nmr Assignments. 5: 151-5. PMID 21213076 DOI: 10.1007/S12104-010-9289-7  0.487
2011 Smith P, Nair PA, Das U, Zhu H, Shuman S. Structures and activities of archaeal members of the LigD 3'-phosphoesterase DNA repair enzyme superfamily. Nucleic Acids Research. 39: 3310-20. PMID 21208981 DOI: 10.1093/Nar/Gkq1163  0.515
2011 Qiu ZR, Schwer B, Shuman S. Determinants of Nam8-dependent splicing of meiotic pre-mRNAs. Nucleic Acids Research. 39: 3427-45. PMID 21208980 DOI: 10.1093/Nar/Gkq1328  0.624
2011 Jain R, Shuman S. Active site mapping and substrate specificity of bacterial Hen1, a manganese-dependent 3' terminal RNA ribose 2'O-methyltransferase. Rna (New York, N.Y.). 17: 429-38. PMID 21205839 DOI: 10.1261/Rna.2500711  0.644
2011 Chakravarty AK, Shuman S. RNA 3'-phosphate cyclase (RtcA) catalyzes ligase-like adenylylation of DNA and RNA 5'-monophosphate ends. The Journal of Biological Chemistry. 286: 4117-22. PMID 21098490 DOI: 10.1074/Jbc.M110.196766  0.525
2011 Meineke B, Schwer B, Schaffrath R, Shuman S. Determinants of eukaryal cell killing by the bacterial ribotoxin PrrC. Nucleic Acids Research. 39: 687-700. PMID 20855293 DOI: 10.1093/Nar/Gkq831  0.443
2010 Samai P, Smith P, Shuman S. Structure of a CRISPR-associated protein Cas2 from Desulfovibrio vulgaris. Acta Crystallographica. Section F, Structural Biology and Crystallization Communications. 66: 1552-6. PMID 21139194 DOI: 10.1107/S1744309110039801  0.805
2010 Unciuleac MC, Shuman S. Double strand break unwinding and resection by the mycobacterial helicase-nuclease AdnAB in the presence of single strand DNA-binding protein (SSB). The Journal of Biological Chemistry. 285: 34319-29. PMID 20736178 DOI: 10.1074/Jbc.M110.162925  0.489
2010 Koster DA, Crut A, Shuman S, Bjornsti MA, Dekker NH. Cellular strategies for regulating DNA supercoiling: a single-molecule perspective. Cell. 142: 519-30. PMID 20723754 DOI: 10.1016/J.Cell.2010.08.001  0.433
2010 Nair PA, Smith P, Shuman S. Structure of bacterial LigD 3'-phosphoesterase unveils a DNA repair superfamily. Proceedings of the National Academy of Sciences of the United States of America. 107: 12822-7. PMID 20616014 DOI: 10.1073/Pnas.1005830107  0.494
2010 Patel A, Yakovleva L, Shuman S, Mondragón A. Crystal structure of a bacterial topoisomerase IB in complex with DNA reveals a secondary DNA binding site. Structure (London, England : 1993). 18: 725-33. PMID 20541510 DOI: 10.1016/J.Str.2010.03.007  0.485
2010 Tanaka N, Smith P, Shuman S. Structure of the RNA 3'-phosphate cyclase-adenylate intermediate illuminates nucleotide specificity and covalent nucleotidyl transfer. Structure (London, England : 1993). 18: 449-57. PMID 20399182 DOI: 10.1016/J.Str.2010.01.016  0.456
2010 Chang J, Schwer B, Shuman S. Mutational analyses of trimethylguanosine synthase (Tgs1) and Mud2: proteins implicated in pre-mRNA splicing. Rna (New York, N.Y.). 16: 1018-31. PMID 20360394 DOI: 10.1261/Rna.2082610  0.455
2010 Schneider S, Pei Y, Shuman S, Schwer B. Separable functions of the fission yeast Spt5 carboxyl-terminal domain (CTD) in capping enzyme binding and transcription elongation overlap with those of the RNA polymerase II CTD. Molecular and Cellular Biology. 30: 2353-64. PMID 20231361 DOI: 10.1128/Mcb.00116-10  0.489
2010 Zhu H, Shuman S. Gap filling activities of Pseudomonas DNA ligase D (LigD) polymerase and functional interactions of LigD with the DNA end-binding Ku protein. The Journal of Biological Chemistry. 285: 4815-25. PMID 20018881 DOI: 10.1074/Jbc.M109.073874  0.519
2010 Jain R, Shuman S. Bacterial Hen1 is a 3' terminal RNA ribose 2'-O-methyltransferase component of a bacterial RNA repair cassette. Rna (New York, N.Y.). 16: 316-23. PMID 20007328 DOI: 10.1261/Rna.1926510  0.676
2010 Wang LK, Shuman S. Mutational analysis of the 5'-OH oligonucleotide phosphate acceptor site of T4 polynucleotide kinase. Nucleic Acids Research. 38: 1304-11. PMID 19966275 DOI: 10.1093/Nar/Gkp1096  0.46
2010 Benarroch D, Jankowska-Anyszka M, Stepinski J, Darzynkiewicz E, Shuman S. Cap analog substrates reveal three clades of cap guanine-N2 methyltransferases with distinct methyl acceptor specificities Rna. 16: 211-220. PMID 19926722 DOI: 10.1261/Rna.1872110  0.318
2010 Unciuleac MC, Shuman S. Characterization of the mycobacterial AdnAB DNA motor provides insights into the evolution of bacterial motor-nuclease machines Journal of Biological Chemistry. 285: 2632-2641. PMID 19920138 DOI: 10.1074/Jbc.M109.076133  0.426
2010 Piserchio A, Nair PA, Shuman S, Ghose R. Solution NMR studies of Chlorella virus DNA ligase-adenylate. Journal of Molecular Biology. 395: 291-308. PMID 19913033 DOI: 10.1016/J.Jmb.2009.11.007  0.468
2009 Tanaka N, Shuman S. Structure-activity relationships in human RNA 3′-phosphate cyclase Rna. 15: 1865-1874. PMID 19690099 DOI: 10.1261/Rna.1771509  0.499
2009 Piserchio A, Nair PA, Shuman S, Ghose R. Sequence-specific 1H N, 13C, and 15N backbone resonance assignments of the 34 kDa Paramecium bursaria Chlorella virus 1 (PBCV1) DNA ligase. Biomolecular Nmr Assignments. 3: 77-80. PMID 19636951 DOI: 10.1007/S12104-009-9145-9  0.449
2009 Sinha KM, Unciuleac MC, Glickman MS, Shuman S. AdnAB: A new DSB-resecting motor-nuclease from mycobacteria Genes and Development. 23: 1423-1437. PMID 19470566 DOI: 10.1101/Gad.1805709  0.653
2009 Schwer B, Schneider S, Pei Y, Aronova A, Shuman S. Characterization of the Schizosaccharomyces pombe Spt5-Spt4 complex. Rna (New York, N.Y.). 15: 1241-50. PMID 19460865 DOI: 10.1261/Rna.1572709  0.443
2009 Keppetipola N, Jain R, Meineke B, Diver M, Shuman S. Structure-activity relationships in Kluyveromyces lactis γ-toxin, a eukaryal tRNA anticodon nuclease Rna. 15: 1036-1044. PMID 19383764 DOI: 10.1261/Rna.1637809  0.819
2009 Shuman S. DNA ligases: Progress and prospects Journal of Biological Chemistry. 284: 17365-17369. PMID 19329793 DOI: 10.1074/Jbc.R900017200  0.507
2009 Sinha KM, Glickman MS, Shuman S. Mutational analysis of mycobacterium UvrD1 identifies functional groups required for ATP hydrolysis, DNA unwinding, and chemomechanical coupling Biochemistry. 48: 4019-4030. PMID 19317511 DOI: 10.1021/Bi900103D  0.68
2009 Jain R, Shuman S. Characterization of a thermostable archaeal polynucleotide kinase homologous to human Clp1 Rna. 15: 923-931. PMID 19299550 DOI: 10.1261/Rna.1492809  0.665
2009 Benarroch D, Qiu ZR, Schwer B, Shuman S. Characterization of a mimivirus RNA cap guanine-N2 methyltransferase Rna. 15: 666-674. PMID 19218551 DOI: 10.1261/Rna.1462109  0.627
2009 Wang LK, Zhu H, Shuman S. Structure-guided Mutational Analysis of the Nucleotidyltransferase Domain of Escherichia coli DNA Ligase (LigA). The Journal of Biological Chemistry. 284: 8486-94. PMID 19150981 DOI: 10.1074/Jbc.M808476200  0.53
2009 Natarajan A, Zhu H, Nair PA, Shuman S, Ghose R. Structure/function Correlations in P. aeruginosa DNA Ligase LigD Biophysical Journal. 96: 58a-59a. DOI: 10.1016/J.Bpj.2008.12.199  0.552
2009 Piserchio A, Nair PA, Shuman SS, Ghose R. Functional Dynamics in Chlorella virus DNA Ligase Biophysical Journal. 96: 322a. DOI: 10.1016/J.Bpj.2008.12.1614  0.406
2008 Ghosh A, Shuman S, Lima CD. The structure of Fcp1, an essential RNA polymerase II CTD phosphatase. Molecular Cell. 32: 478-90. PMID 19026779 DOI: 10.1016/J.Molcel.2008.09.021  0.49
2008 Zheng S, Shuman S. Mutational analysis of vaccinia virus mRNA cap (guanine-N7) methyltransferase reveals essential contributions of the N-terminal peptide that closes over the active site Rna. 14: 2297-2304. PMID 18799596 DOI: 10.1261/Rna.1201308  0.433
2008 Jain R, Shuman S. Polyphosphatase activity of CthTTM, a bacterial triphosphate tunnel metalloenzyme. The Journal of Biological Chemistry. 283: 31047-57. PMID 18782773 DOI: 10.1074/Jbc.M805392200  0.622
2008 Hausmann S, Zheng S, Costanzo M, Brost RL, Garcin D, Boone C, Shuman S, Schwer B. Genetic and biochemical analysis of yeast and human cap trimethylguanosine synthase: functional overlap of 2,2,7-trimethylguanosine caps, small nuclear ribonucleoprotein components, pre-mRNA splicing factors, and RNA decay pathways. The Journal of Biological Chemistry. 283: 31706-18. PMID 18775984 DOI: 10.1074/Jbc.M806127200  0.464
2008 Keppetipola N, Shuman S. A phosphate-binding histidine of binuclear metallophosphodiesterase enzymes is a determinant of 2',3'-cyclic nucleotide phosphodiesterase activity. The Journal of Biological Chemistry. 283: 30942-9. PMID 18757371 DOI: 10.1074/Jbc.M805064200  0.792
2008 Deng L, Dai P, Parikh T, Cao H, Bhoj V, Sun Q, Chen Z, Merghoub T, Houghton A, Shuman S. Vaccinia virus subverts a mitochondrial antiviral signaling protein-dependent innate immune response in keratinocytes through its double-stranded RNA binding protein, E3 Journal of Virology. 82: 10735-10746. PMID 18715932 DOI: 10.1128/Jvi.01305-08  0.377
2008 Sinha KM, Stephanou NC, Unciuleac MC, Glickman MS, Shuman S. Domain requirements for DNA unwinding by mycobacterial UvrD2, an essential DNA helicase. Biochemistry. 47: 9355-64. PMID 18702526 DOI: 10.1021/Bi800725Q  0.65
2008 Nandakumar J, Schwer B, Schaffrath R, Shuman S. RNA repair: an antidote to cytotoxic eukaryal RNA damage. Molecular Cell. 31: 278-86. PMID 18657509 DOI: 10.1016/J.Molcel.2008.05.019  0.461
2008 Ramirez A, Shuman S, Schwer B. Human RNA 5'-kinase (hClp1) can function as a tRNA splicing enzyme in vivo. Rna (New York, N.Y.). 14: 1737-45. PMID 18648070 DOI: 10.1261/Rna.1142908  0.492
2008 Wang LK, Nair PA, Shuman S. Structure-guided mutational analysis of the OB, HhH, and BRCT domains of Escherichia coli DNA ligase. The Journal of Biological Chemistry. 283: 23343-52. PMID 18515356 DOI: 10.1074/Jbc.M802945200  0.501
2008 Crut A, Nair PA, Koster DA, Shuman S, Dekker NH. Dynamics of phosphodiester synthesis by DNA ligase. Proceedings of the National Academy of Sciences of the United States of America. 105: 6894-9. PMID 18458338 DOI: 10.1073/Pnas.0800113105  0.442
2008 Benarroch D, Smith P, Shuman S. Characterization of a trifunctional mimivirus mRNA capping enzyme and crystal structure of the RNA triphosphatase domain. Structure (London, England : 1993). 16: 501-12. PMID 18400173 DOI: 10.1016/J.Str.2008.01.009  0.53
2008 Yakovleva L, Chen S, Hecht SM, Shuman S. Chemical and traditional mutagenesis of vaccinia DNA topoisomerase provides insights to cleavage site recognition and transesterification chemistry. The Journal of Biological Chemistry. 283: 16093-103. PMID 18367446 DOI: 10.1074/Jbc.M801595200  0.512
2008 Aniukwu J, Glickman MS, Shuman S. The pathways and outcomes of mycobacterial NHEJ depend on the structure of the broken DNA ends. Genes & Development. 22: 512-27. PMID 18281464 DOI: 10.1101/Gad.1631908  0.652
2008 Zheng S, Shuman S. Structure-function analysis of vaccinia virus mRNA cap (guanine-N7) methyltransferase Rna. 14: 696-705. PMID 18256245 DOI: 10.1261/Rna.928208  0.497
2008 Zhu H, Shuman S. Bacterial nonhomologous end joining ligases preferentially seal breaks with a 3′-OH monoribonucleotide Journal of Biological Chemistry. 283: 8331-8339. PMID 18203718 DOI: 10.1074/Jbc.M705476200  0.508
2008 Schwer B, Aronova A, Ramirez A, Braun P, Shuman S. Mammalian 2',3' cyclic nucleotide phosphodiesterase (CNP) can function as a tRNA splicing enzyme in vivo. Rna (New York, N.Y.). 14: 204-10. PMID 18094118 DOI: 10.1261/Rna.858108  0.486
2007 Raymond A, Shuman S. Deinococcus radiodurans RNA ligase exemplifies a novel ligase clade with a distinctive N-terminal module that is important for 5'-PO 4 nick sealing and ligase adenylylation but dispensable for phosphodiester formation at an adenylylated nick. Nucleic Acids Research. 35: 839-849. PMID 28383729 DOI: 10.1093/nar/gkl1090  0.396
2007 Keppetipola N, Shuman S. Characterization of the 2',3' cyclic phosphodiesterase activities of Clostridium thermocellum polynucleotide kinase-phosphatase and bacteriophage lambda phosphatase. Nucleic Acids Research. 35: 7721-32. PMID 17986465 DOI: 10.1093/Nar/Gkm868  0.824
2007 Shuman S, Glickman MS. Bacterial DNA repair by non-homologous end joining. Nature Reviews. Microbiology. 5: 852-61. PMID 17938628 DOI: 10.1038/Nrmicro1768  0.6
2007 Zheng S, Shuman S, Schwer B. Sinefungin resistance of Saccharomyces cerevisiae arising from Sam3 mutations that inactivate the AdoMet transporter or from increased expression of AdoMet synthase plus mRNA cap guanine-N7 methyltransferase. Nucleic Acids Research. 35: 6895-903. PMID 17932050 DOI: 10.1093/Nar/Gkm817  0.352
2007 Deng L, Dai P, Ciro A, Smee DF, Djaballah H, Shuman S. Identification of novel antipoxviral agents: mitoxantrone inhibits vaccinia virus replication by blocking virion assembly. Journal of Virology. 81: 13392-402. PMID 17928345 DOI: 10.1128/Jvi.00770-07  0.327
2007 Shuman S. Transcriptional Networking Cap-tures the 7SK RNA 5′-γ-Methyltransferase Molecular Cell. 27: 517-519. PMID 17707222 DOI: 10.1016/J.Molcel.2007.08.001  0.393
2007 Nair PA, Nandakumar J, Smith P, Odell M, Lima CD, Shuman S. Structural basis for nick recognition by a minimal pluripotent DNA ligase. Nature Structural & Molecular Biology. 14: 770-8. PMID 17618295 DOI: 10.1038/Nsmb1266  0.487
2007 Wang LK, Nandakumar J, Schwer B, Shuman S. The C-terminal domain of T4 RNA ligase 1 confers specificity for tRNA repair. Rna (New York, N.Y.). 13: 1235-44. PMID 17585047 DOI: 10.1261/Rna.591807  0.499
2007 Stephanou NC, Gao F, Bongiorno P, Ehrt S, Schnappinger D, Shuman S, Glickman MS. Mycobacterial nonhomologous end joining mediates mutagenic repair of chromosomal double-strand DNA breaks. Journal of Bacteriology. 189: 5237-46. PMID 17496093 DOI: 10.1128/Jb.00332-07  0.575
2007 Zhu H, Smith P, Wang LK, Shuman S. Structure-function analysis of the 3' phosphatase component of T4 polynucleotide kinase/phosphatase. Virology. 366: 126-36. PMID 17493655 DOI: 10.1016/J.Virol.2007.03.059  0.439
2007 Keppetipola N, Nandakumar J, Shuman S. Reprogramming the tRNA-splicing activity of a bacterial RNA repair enzyme. Nucleic Acids Research. 35: 3624-30. PMID 17488852 DOI: 10.1093/Nar/Gkm110  0.826
2007 Zhu H, Shuman S. Characterization of Agrobacterium tumefaciens DNA ligases C and D Nucleic Acids Research. 35: 3631-3645. PMID 17488851 DOI: 10.1093/Nar/Gkm145  0.523
2007 Nandakumar J, Nair PA, Shuman S. Last stop on the road to repair: structure of E. coli DNA ligase bound to nicked DNA-adenylate. Molecular Cell. 26: 257-71. PMID 17466627 DOI: 10.1016/J.Molcel.2007.02.026  0.491
2007 Sinha KM, Stephanou NC, Gao F, Glickman MS, Shuman S. Mycobacterial UvrD1 is a Ku-dependent DNA helicase that plays a role in multiple DNA repair events, including double-strand break repair. The Journal of Biological Chemistry. 282: 15114-25. PMID 17376770 DOI: 10.1074/Jbc.M701167200  0.63
2007 Keppetipola N, Jain R, Shuman S. Novel triphosphate phosphohydrolase activity of Clostridium thermocellum TTM, a member of the triphosphate tunnel metalloenzyme superfamily. The Journal of Biological Chemistry. 282: 11941-9. PMID 17303560 DOI: 10.1074/Jbc.M611328200  0.83
2007 Hausmann S, Ramirez A, Schneider S, Schwer B, Shuman S. Biochemical and genetic analysis of RNA cap guanine-N2 methyltransferases from Giardia lamblia and Schizosaccharomyces pombe. Nucleic Acids Research. 35: 1411-20. PMID 17284461 DOI: 10.1093/Nar/Gkl1150  0.45
2007 Raymond A, Shuman S. Deinococcus radiodurans RNA ligase exemplifies a novel ligase clade with a distinctive N-terminal module that is important for 5′-PO4 nick sealing and ligase adenylylation but dispensable for phosphodiester formation at an adenylylated nick Nucleic Acids Research. 35: 839-849. PMID 17204483 DOI: 10.1093/Nar/Gkl1090  0.498
2007 Tian L, Shuman S. Vaccinia topoisomerase mutants illuminate roles for Phe59, Gly73, Gln69 and Phe215. Virology. 359: 466-76. PMID 17059840 DOI: 10.1016/J.Virol.2006.08.056  0.681
2007 Benarroch D, Claverie JM, Raoult D, Shuman S. Characterization of mimivirus DNA topoisomerase IB suggests horizontal gene transfer between eukaryal viruses and bacteria. Journal of Virology. 80: 314-21. PMID 16352556 DOI: 10.1128/Jvi.80.1.314-321.2006  0.445
2006 Wang LK, Schwer B, Shuman S. Structure-guided mutational analysis of T4 RNA ligase 1. Rna (New York, N.Y.). 12: 2126-34. PMID 17068206 DOI: 10.1261/Rna.271706  0.528
2006 Nandakumar J, Shuman S, Lima CD. RNA ligase structures reveal the basis for RNA specificity and conformational changes that drive ligation forward. Cell. 127: 71-84. PMID 17018278 DOI: 10.1016/J.Cell.2006.08.038  0.519
2006 Yakovleva L, Lai J, Kool ET, Shuman S. Nonpolar nucleobase analogs illuminate requirements for site-specific DNA cleavage by vaccinia topoisomerase. The Journal of Biological Chemistry. 281: 35914-21. PMID 17005552 DOI: 10.1074/Jbc.M608349200  0.475
2006 Zheng S, Hausmann S, Liu Q, Ghosh A, Schwer B, Lima CD, Shuman S. Mutational analysis of Encephalitozoon cuniculi mRNA cap (guanine-N7) methyltransferase, structure of the enzyme bound to sinefungin, and evidence that cap methyltransferase is the target of sinefungin's antifungal activity. The Journal of Biological Chemistry. 281: 35904-13. PMID 16971388 DOI: 10.1074/Jbc.M607292200  0.422
2006 Benarroch D, Shuman S. Characterization of mimivirus NAD+-dependent DNA ligase Virology. 353: 133-143. PMID 16844179 DOI: 10.1016/J.Virol.2006.04.032  0.549
2006 Yakovleva L, Shuman S. Nucleotide misincorporation, 3′-mismatch extension, and responses to abasic sites and DNA adducts by the polymerase component of bacterial DNA ligase D Journal of Biological Chemistry. 281: 25026-25040. PMID 16816388 DOI: 10.1074/Jbc.M603302200  0.529
2006 Gong C, Smith P, Shuman S. Structure-function analysis of Plasmodium RNA triphosphatase and description of a triphosphate tunnel metalloenzyme superfamily that includes Cet1-like RNA triphosphatases and CYTH proteins. Rna (New York, N.Y.). 12: 1468-74. PMID 16809816 DOI: 10.1261/Rna.119806  0.687
2006 Yakovleva L, Handy CJ, Yagi H, Sayer JM, Jerina DM, Shuman S. Intercalating polycyclic aromatic hydrocarbon-DNA adducts poison DNA religation by Vaccinia topoisomerase and act as roadblocks to digestion by exonuclease III. Biochemistry. 45: 7644-53. PMID 16768460 DOI: 10.1021/Bi060158H  0.468
2006 Schwer B, Shuman S. Genetic analysis of poxvirus mRNA cap methyltransferase: suppression of conditional mutations in the stimulatory D12 subunit by second-site mutations in the catalytic D1 subunit. Virology. 352: 145-56. PMID 16716374 DOI: 10.1016/J.Virol.2006.03.050  0.442
2006 Schwer B, Hausmann S, Schneider S, Shuman S. Poxvirus mRNA cap methyltransferase. Bypass of the requirement for the stimulatory subunit by mutations in the catalytic subunit and evidence for intersubunit allostery. The Journal of Biological Chemistry. 281: 18953-60. PMID 16707499 DOI: 10.1074/Jbc.M602867200  0.472
2006 Keppetipola N, Shuman S. Distinct enzymic functional groups are required for the phosphomonoesterase and phosphodiesterase activities of Clostridium thermocellum polynucleotide kinase/phosphatase. The Journal of Biological Chemistry. 281: 19251-9. PMID 16675457 DOI: 10.1074/Jbc.M602549200  0.8
2006 Zhu H, Shuman S. Substrate specificity and structure-function analysis of the 3′-phosphoesterase component of the bacterial NHEJ protein, DNA ligase D Journal of Biological Chemistry. 281: 13873-13881. PMID 16540477 DOI: 10.1074/Jbc.M600055200  0.517
2006 Akey D, Martins A, Aniukwu J, Glickman MS, Shuman S, Berger JM. Crystal structure and nonhomologous end-joining function of the ligase component of Mycobacterium DNA ligase D. The Journal of Biological Chemistry. 281: 13412-23. PMID 16476729 DOI: 10.1074/Jbc.M513550200  0.682
2006 Zhu H, Nandakumar J, Aniukwu J, Wang LK, Glickman MS, Lima CD, Shuman S. Atomic structure and nonhomologous end-joining function of the polymerase component of bacterial DNA ligase D. Proceedings of the National Academy of Sciences of the United States of America. 103: 1711-6. PMID 16446439 DOI: 10.1073/Pnas.0509083103  0.696
2006 Pei Y, Du H, Singer J, Stamour C, Granitto S, Shuman S, Fisher RP. Cyclin-dependent kinase 9 (Cdk9) of fission yeast is activated by the CDK-activating kinase Csk1, overlaps functionally with the TFIIH-associated kinase Mcs6, and associates with the mRNA cap methyltransferase Pcm1 in vivo. Molecular and Cellular Biology. 26: 777-88. PMID 16428435 DOI: 10.1128/Mcb.26.3.777-788.2006  0.4
2006 Wang LK, Schwer B, Englert M, Beier H, Shuman S. Structure-function analysis of the kinase-CPD domain of yeast tRNA ligase (Trl1) and requirements for complementation of tRNA splicing by a plant Trl1 homolog. Nucleic Acids Research. 34: 517-27. PMID 16428247 DOI: 10.1093/Nar/Gkj441  0.495
2006 Patel A, Shuman S, Mondragón A. Crystal structure of a bacterial type IB DNA topoisomerase reveals a preassembled active site in the absence of DNA. The Journal of Biological Chemistry. 281: 6030-7. PMID 16368685 DOI: 10.1074/Jbc.M512332200  0.534
2006 Keppetipola N, Shuman S. Mechanism of the phosphatase component of Clostridium thermocellum polynucleotide kinase-phosphatase. Rna (New York, N.Y.). 12: 73-82. PMID 16301605 DOI: 10.1261/Rna.2196406  0.821
2005 Suh MH, Ye P, Zhang M, Hausmann S, Shuman S, Gnatt AL, Fu J. Fcp1 directly recognizes the C-terminal domain (CTD) and interacts with a site on RNA polymerase II distinct from the CTD. Proceedings of the National Academy of Sciences of the United States of America. 102: 17314-9. PMID 16301539 DOI: 10.1073/Pnas.0507987102  0.427
2005 Khalid MF, Damha MJ, Shuman S, Schwer B. Structure-function analysis of yeast RNA debranching enzyme (Dbr1), a manganese-dependent phosphodiesterase. Nucleic Acids Research. 33: 6349-60. PMID 16275784 DOI: 10.1093/Nar/Gki934  0.544
2005 Moreno-Herrero F, Holtzer L, Koster DA, Shuman S, Dekker C, Dekker NH. Atomic force microscopy shows that vaccinia topoisomerase IB generates filaments on DNA in a cooperative fashion Nucleic Acids Research. 33: 5945-5953. PMID 16237128 DOI: 10.1093/Nar/Gki906  0.425
2005 Keppetipola N, Shuman S. Characterization of a thermophilic ATP-dependent DNA ligase from the euryarchaeon Pyrococcus horikoshii. Journal of Bacteriology. 187: 6902-8. PMID 16199559 DOI: 10.1128/Jb.187.20.6902-6908.2005  0.818
2005 Hausmann S, Koiwa H, Krishnamurthy S, Hampsey M, Shuman S. Different strategies for carboxyl-terminal domain (CTD) recognition by serine 5-specific CTD phosphatases. The Journal of Biological Chemistry. 280: 37681-8. PMID 16148005 DOI: 10.1074/Jbc.M505292200  0.42
2005 Hausmann S, Shuman S. Giardia lamblia RNA cap guanine-N2 methyltransferase (Tgs2) Journal of Biological Chemistry. 280: 32101-32106. PMID 16046409 DOI: 10.1074/Jbc.M506438200  0.341
2005 Zhu H, Wang LK, Shuman S. Essential constituents of the 3'-phosphoesterase domain of bacterial DNA ligase D, a nonhomologous end-joining enzyme. The Journal of Biological Chemistry. 280: 33707-15. PMID 16046407 DOI: 10.1074/Jbc.M506838200  0.516
2005 Martins A, Shuman S. An end-healing enzyme from Clostridium thermocellum with 5′ kinase, 2′,3′ phosphatase, and adenylyltransferase activities Rna. 11: 1271-1280. PMID 15987807 DOI: 10.1261/Rna.2690505  0.568
2005 Li KW, Shuman S. Structure-function analysis of yeast tRNA ligase Rna. 11: 966-975. PMID 15923379 DOI: 10.1261/Rna.2170305  0.557
2005 Zhu H, Shuman S. Novel 3′-ribonuclease and 3′-phosphatase activities of the bacterial non-homologous end-joining protein, DNA ligase D Journal of Biological Chemistry. 280: 25973-25981. PMID 15897197 DOI: 10.1074/Jbc.M504002200  0.53
2005 Nandakumar J, Shuman S. Dual mechanisms whereby a broken RNA end assists the catalysis of its repair by T4 RNA ligase 2. The Journal of Biological Chemistry. 280: 23484-9. PMID 15851476 DOI: 10.1074/Jbc.M500831200  0.46
2005 Tian L, Claeboe CD, Hecht SM, Shuman S. Mechanistic plasticity of DNA topoisomerase IB: phosphate electrostatics dictate the need for a catalytic arginine. Structure (London, England : 1993). 13: 513-20. PMID 15837190 DOI: 10.1016/J.Str.2005.02.001  0.684
2005 Koster DA, Croquette V, Dekker C, Shuman S, Dekker NH. Friction and torque govern the relaxation of DNA supercoils by eukaryotic topoisomerase IB. Nature. 434: 671-4. PMID 15800630 DOI: 10.1038/Nature03395  0.442
2005 Gong C, Bongiorno P, Martins A, Stephanou NC, Zhu H, Shuman S, Glickman MS. Mechanism of nonhomologous end-joining in mycobacteria: a low-fidelity repair system driven by Ku, ligase D and ligase C. Nature Structural & Molecular Biology. 12: 304-12. PMID 15778718 DOI: 10.1038/Nsmb915  0.732
2005 Hausmann S, Zheng S, Fabrega C, Schneller SW, Lima CD, Shuman S. Encephalitozoon cuniculi mRNA cap (guanine N-7) methyltransferase: methyl acceptor specificity, inhibition BY S-adenosylmethionine analogs, and structure-guided mutational analysis. The Journal of Biological Chemistry. 280: 20404-12. PMID 15760890 DOI: 10.1074/Jbc.M501073200  0.357
2005 Changela A, Martins A, Shuman S, Mondragón A. Crystal structure of baculovirus RNA triphosphatase complexed with phosphate. The Journal of Biological Chemistry. 280: 17848-56. PMID 15713658 DOI: 10.1074/Jbc.M500885200  0.487
2005 Zhu H, Shuman S. Structure-guided mutational analysis of the nucleotidyltransferase domain of Escherichia coli NAD+-dependent DNA ligase (LigA) Journal of Biological Chemistry. 280: 12137-12144. PMID 15671015 DOI: 10.1074/Jbc.M413685200  0.505
2005 Sawaya R, Schwer B, Shuman S. Structure-function analysis of the yeast NAD+-dependent tRNA 2'-phosphotransferase Tpt1. Rna (New York, N.Y.). 11: 107-13. PMID 15611301 DOI: 10.1261/Rna.7193705  0.669
2005 Hausmann S, Shuman S. Specificity and mechanism of RNA cap guanine-N2 methyltransferase (Tgs1) Journal of Biological Chemistry. 280: 4021-4024. PMID 15590684 DOI: 10.1074/Jbc.C400554200  0.414
2005 Hausmann S, Altura MA, Witmer M, Singer SM, Elmendorf HG, Shuman S. Yeast-like mRNA capping apparatus in Giardia lamblia. The Journal of Biological Chemistry. 280: 12077-86. PMID 15556935 DOI: 10.1074/Jbc.M412063200  0.329
2005 Zhu H, Shuman S. A primer-dependent polymerase function of Pseudomonas aeruginosa ATP-dependent DNA ligase (LigD) Journal of Biological Chemistry. 280: 418-427. PMID 15520014 DOI: 10.1074/Jbc.M410110200  0.553
2004 Shuman S, Lima CD. The polynucleotide ligase and RNA capping enzyme superfamily of covalent nucleotidyltransferases. Current Opinion in Structural Biology. 14: 757-64. PMID 15582400 DOI: 10.1016/J.Sbi.2004.10.006  0.589
2004 Nandakumar J, Shuman S. How an RNA ligase discriminates RNA versus DNA damage. Molecular Cell. 16: 211-21. PMID 15494308 DOI: 10.1016/J.Molcel.2004.09.022  0.523
2004 Koiwa H, Hausmann S, Bang WY, Ueda A, Kondo N, Hiraguri A, Fukuhara T, Bahk JD, Yun DJ, Bressan RA, Hasegawa PM, Shuman S. Arabidopsis C-terminal domain phosphatase-like 1 and 2 are essential Ser-5-specific C-terminal domain phosphatases. Proceedings of the National Academy of Sciences of the United States of America. 101: 14539-44. PMID 15388846 DOI: 10.1073/Pnas.0403174101  0.502
2004 Martins A, Shuman S. An RNA ligase from Deinococcus radiodurans Journal of Biological Chemistry. 279: 50654-50661. PMID 15333634 DOI: 10.1074/Jbc.M407657200  0.53
2004 Shuman S. NAD+ specificity of bacterial DNA ligase revealed Structure. 12: 1335-1336. PMID 15296724 DOI: 10.1016/J.Str.2004.07.002  0.451
2004 Tian L, Sayer JM, Jerina DM, Shuman S. Individual nucleotide bases, not base pairs, are critical for triggering site-specific DNA cleavage by vaccinia topoisomerase. The Journal of Biological Chemistry. 279: 39718-26. PMID 15252055 DOI: 10.1074/Jbc.M407376200  0.643
2004 Hausmann S, Schwer B, Shuman S. An encephalitozoon cuniculi ortholog of the RNA polymerase II carboxyl-terminal domain (CTD) serine phosphatase Fcp1. Biochemistry. 43: 7111-20. PMID 15170348 DOI: 10.1021/Bi0499617  0.495
2004 Nandakumar J, Ho CK, Lima CD, Shuman S. RNA substrate specificity and structure-guided mutational analysis of bacteriophage T4 RNA ligase 2. The Journal of Biological Chemistry. 279: 31337-47. PMID 15084599 DOI: 10.1074/Jbc.M402394200  0.542
2004 Zhu H, Yin S, Shuman S. Characterization of polynucleotide kinase/phosphatase enzymes from Mycobacteriophages omega and Cjw1 and vibriophage KVP40. The Journal of Biological Chemistry. 279: 26358-69. PMID 15056675 DOI: 10.1074/Jbc.M403200200  0.504
2004 Yakovleva L, Handy CJ, Sayer JM, Pirrung M, Jerina DM, Shuman S. Benzo[c]phenanthrene adducts and nogalamycin inhibit DNA transesterification by vaccinia topoisomerase. The Journal of Biological Chemistry. 279: 23335-42. PMID 15044474 DOI: 10.1074/Jbc.M401203200  0.445
2004 Gong C, Martins A, Bongiorno P, Glickman M, Shuman S. Biochemical and genetic analysis of the four DNA ligases of mycobacteria. The Journal of Biological Chemistry. 279: 20594-606. PMID 14985346 DOI: 10.1074/Jbc.M401841200  0.736
2004 Schwer B, Sawaya R, Ho CK, Shuman S. Portability and fidelity of RNA-repair systems. Proceedings of the National Academy of Sciences of the United States of America. 101: 2788-93. PMID 14973195 DOI: 10.1073/Pnas.0305859101  0.684
2004 Yin S, Kiong Ho C, Miller ES, Shuman S. Characterization of bacteriophage KVP40 and T4 RNA ligase 2. Virology. 319: 141-51. PMID 14967495 DOI: 10.1016/J.Virol.2003.10.037  0.491
2004 Schroeder SC, Zorio DA, Schwer B, Shuman S, Bentley D. A function of yeast mRNA cap methyltransferase, Abd1, in transcription by RNA polymerase II. Molecular Cell. 13: 377-87. PMID 14967145 DOI: 10.1016/S1097-2765(04)00007-3  0.393
2004 Ho CK, Wang LK, Lima CD, Shuman S. Structure and mechanism of RNA ligase. Structure (London, England : 1993). 12: 327-39. PMID 14962393 DOI: 10.1016/J.Str.2004.01.011  0.532
2004 Liao S, Mao C, Birktoft JJ, Shuman S, Seeman NC. Resolution of undistorted symmetric immobile DNA junctions by vaccinia topoisomerase I. Biochemistry. 43: 1520-31. PMID 14769028 DOI: 10.1021/Bi0358061  0.447
2004 Martins A, Shuman S. Characterization of a Baculovirus Enzyme with RNA Ligase, Polynucleotide 5′-Kinase, and Polynucleotide 3′-Phosphatase Activities Journal of Biological Chemistry. 279: 18220-18231. PMID 14747466 DOI: 10.1074/Jbc.M313386200  0.527
2004 Fabrega C, Hausmann S, Shen V, Shuman S, Lima CD. Structure and mechanism of mRNA cap (guanine-N7) methyltransferase. Molecular Cell. 13: 77-89. PMID 14731396 DOI: 10.1016/S1097-2765(03)00522-7  0.337
2004 Tian L, Claeboe CD, Hecht SM, Shuman S. Remote phosphate contacts trigger assembly of the active site of DNA topoisomerase IB. Structure (London, England : 1993). 12: 31-40. PMID 14725763 DOI: 10.1016/J.Str.2003.11.025  0.668
2004 Odell M, Malinina L, Sriskanda V, Teplova M, Shuman S. Analysis of the DNA joining repertoire of Chlorella virus DNA ligase and a new crystal structure of the ligase-adenylate intermediate. Nucleic Acids Research. 31: 5090-100. PMID 12930960 DOI: 10.1093/Nar/Gkg665  0.51
2003 Hausmann S, Erdjument-Bromage H, Shuman S. Schizosaccharomyces pombe carboxyl-terminal domain (CTD) phosphatase Fcp1: distributive mechanism, minimal CTD substrate, and active site mapping. The Journal of Biological Chemistry. 279: 10892-900. PMID 14701811 DOI: 10.1074/Jbc.M312513200  0.453
2003 Gong C, Martins A, Shuman S. Structure-function analysis of Trypanosoma brucei RNA triphosphatase and evidence for a two-metal mechanism. The Journal of Biological Chemistry. 278: 50843-52. PMID 14525979 DOI: 10.1074/Jbc.M309188200  0.709
2003 Sawaya R, Schwer B, Shuman S. Genetic and biochemical analysis of the functional domains of yeast tRNA ligase. The Journal of Biological Chemistry. 278: 43928-38. PMID 12933796 DOI: 10.1074/Jbc.M307839200  0.705
2003 Yakovleva L, Tian L, Sayer JM, Kalena GP, Kroth H, Jerina DM, Shuman S. Site-specific DNA transesterification by vaccinia topoisomerase: effects of benzo[alpha]pyrene-dA, 8-oxoguanine, 8-oxoadenine and 2-aminopurine modifications. The Journal of Biological Chemistry. 278: 42170-7. PMID 12909623 DOI: 10.1074/Jbc.M308079200  0.646
2003 Pei Y, Shuman S. Characterization of the Schizosaccharomyces pombe Cdk9/Pch1 protein kinase: Spt5 phosphorylation, autophosphorylation, and mutational analysis. The Journal of Biological Chemistry. 278: 43346-56. PMID 12904290 DOI: 10.1074/Jbc.M307319200  0.401
2003 Tian L, Claeboe CD, Hecht SM, Shuman S. Guarding the genome: electrostatic repulsion of water by DNA suppresses a potent nuclease activity of topoisomerase IB. Molecular Cell. 12: 199-208. PMID 12887905 DOI: 10.1016/S1097-2765(03)00263-6  0.665
2003 Sawaya R, Shuman S. Mutational analysis of the guanylyltransferase component of Mammalian mRNA capping enzyme. Biochemistry. 42: 8240-9. PMID 12846573 DOI: 10.1021/Bi034396D  0.707
2003 Fabrega C, Shen V, Shuman S, Lima CD. Structure of an mRNA capping enzyme bound to the phosphorylated carboxy-terminal domain of RNA polymerase II. Molecular Cell. 11: 1549-61. PMID 12820968 DOI: 10.1016/S1097-2765(03)00187-4  0.489
2003 Saha N, Shuman S, Schwer B. Yeast-based genetic system for functional analysis of poxvirus mRNA cap methyltransferase. Journal of Virology. 77: 7300-7. PMID 12805428 DOI: 10.1128/Jvi.77.13.7300-7307.2003  0.459
2003 Hausmann S, Pei Y, Shuman S. Homodimeric quaternary structure is required for the in vivo function and thermal stability of Saccharomyces cerevisiae and Schizosaccharomyces pombe RNA triphosphatases. The Journal of Biological Chemistry. 278: 30487-96. PMID 12788946 DOI: 10.1074/Jbc.M303060200  0.496
2003 Wang LK, Ho CK, Pei Y, Shuman S. Mutational analysis of bacteriophage T4 RNA ligase 1. Different functional groups are required for the nucleotidyl transfer and phosphodiester bond formation steps of the ligation reaction. The Journal of Biological Chemistry. 278: 29454-62. PMID 12766156 DOI: 10.1074/Jbc.M304320200  0.545
2003 Gong C, Shuman S. Mapping the active site of vaccinia virus RNA triphosphatase. Virology. 309: 125-34. PMID 12726733 DOI: 10.1016/S0042-6822(03)00002-3  0.691
2003 Yin S, Ho CK, Shuman S. Structure-function analysis of T4 RNA ligase 2. The Journal of Biological Chemistry. 278: 17601-8. PMID 12611899 DOI: 10.1074/Jbc.M300817200  0.561
2003 Martins A, Shuman S. Mapping the triphosphatase active site of baculovirus mRNA capping enzyme LEF4 and evidence for a two-metal mechanism Nucleic Acids Research. 31: 1455-1463. PMID 12595553 DOI: 10.1093/Nar/Gkg244  0.5
2003 Hausmann S, Shuman S. Defining the active site of Schizosaccharomyces pombe C-terminal domain phosphatase Fcp1 Journal of Biological Chemistry. 278: 13627-13632. PMID 12556522 DOI: 10.1074/Jbc.M213191200  0.491
2003 Tian L, Sayer JM, Kroth H, Kalena G, Jerina DM, Shuman S. Benzo[a]pyrene-dG adduct interference illuminates the interface of vaccinia topoisomerase with the DNA minor groove. The Journal of Biological Chemistry. 278: 9905-11. PMID 12524450 DOI: 10.1074/Jbc.M212468200  0.623
2003 Pei Y, Schwer B, Shuman S. Interactions between fission yeast Cdk9, its cyclin partner Pch1, and mRNA capping enzyme Pct1 suggest an elongation checkpoint for mRNA quality control. The Journal of Biological Chemistry. 278: 7180-8. PMID 12475973 DOI: 10.1074/Jbc.M211713200  0.481
2002 Martins A, Shuman S. The domain order of mammalian capping enzyme can be inverted and baculovirus phosphatase can function in cap formation in vivo Virology. 304: 167-175. PMID 12504559 DOI: 10.1006/Viro.2002.1606  0.522
2002 Martins A, Shuman S. Mutational analysis of baculovirus phosphatase identifies structural residues important for triphosphatase activity in vitro and in vivo Biochemistry. 41: 13403-13409. PMID 12416985 DOI: 10.1021/Bi0265426  0.517
2002 Chiu YL, Ho CK, Saha N, Schwer B, Shuman S, Rana TM. Tat stimulates cotranscriptional capping of HIV mRNA. Molecular Cell. 10: 585-97. PMID 12408826 DOI: 10.1016/S1097-2765(02)00630-5  0.325
2002 Ho CK, Shuman S. Bacteriophage T4 RNA ligase 2 (gp24.1) exemplifies a family of RNA ligases found in all phylogenetic domains. Proceedings of the National Academy of Sciences of the United States of America. 99: 12709-14. PMID 12228725 DOI: 10.1073/Pnas.192184699  0.487
2002 Shuman S. What messenger RNA capping tells us about eukaryotic evolution Nature Reviews Molecular Cell Biology. 3: 619-625. PMID 12154373 DOI: 10.1038/Nrm880  0.464
2002 Wang LK, Lima CD, Shuman S. Structure and mechanism of T4 polynucleotide kinase: an RNA repair enzyme. The Embo Journal. 21: 3873-80. PMID 12110598 DOI: 10.1093/Emboj/Cdf397  0.503
2002 Hausmann S, Shuman S. Characterization of the CTD phosphatase Fcp1 from fission yeast. Preferential dephosphorylation of serine 2 versus serine 5 Journal of Biological Chemistry. 277: 21213-21220. PMID 11934898 DOI: 10.1074/Jbc.M202056200  0.472
2002 Pei Y, Shuman S. Interactions between fission yeast mRNA capping enzymes and elongation factor Spt5. The Journal of Biological Chemistry. 277: 19639-48. PMID 11893740 DOI: 10.1074/Jbc.M200015200  0.473
2002 Gong C, Shuman S. Chlorella virus RNA triphosphatase. Mutational analysis and mechanism of inhibition by tripolyphosphate. The Journal of Biological Chemistry. 277: 15317-24. PMID 11844801 DOI: 10.1074/Jbc.M200532200  0.706
2002 Wang LK, Shuman S. Mutational analysis defines the 5′-kinase and 3′-phosphatase active sites of T4 polynucleotide kinase Nucleic Acids Research. 30: 1073-1080. PMID 11842120 DOI: 10.1093/Nar/30.4.1073  0.441
2002 Sriskanda V, Shuman S. Role of nucleotidyltransferase motifs I, III and IV in the catalysis of phosphodiester bond formation by Chlorella virus DNA ligase Nucleic Acids Research. 30: 903-911. PMID 11842101 DOI: 10.1093/Nar/30.4.903  0.523
2002 Krogh BO, Shuman S. A poxvirus-like type IB topoisomerase family in bacteria Proceedings of the National Academy of Sciences of the United States of America. 99: 1853-1858. PMID 11830640 DOI: 10.1073/Pnas.032613199  0.491
2002 Sriskanda V, Shuman S. Conserved residues in domain Ia are required for the reaction of Escherichia coli DNA ligase with NAD+ Journal of Biological Chemistry. 277: 9695-9700. PMID 11781321 DOI: 10.1074/Jbc.M111164200  0.536
2002 Krogh BO, Shuman S. Proton relay mechanism of general acid catalysis by DNA topoisomerase IB Journal of Biological Chemistry. 277: 5711-5714. PMID 11756402 DOI: 10.1074/Jbc.C100681200  0.473
2002 Sriskanda V, Shuman S. Role of nucleotidyl transferase motif V in strand joining by Chlorella virus DNA ligase Journal of Biological Chemistry. 277: 9661-9667. PMID 11751916 DOI: 10.1074/Jbc.M110613200  0.547
2002 Odell M, Sriskanda V, Shuman S, Nikolov DB. Crystal structure of eukaryotic DNA ligase-adenylate illuminates the mechanism of nick sensing and strand joining. Molecular Cell. 6: 1183-93. PMID 11106756 DOI: 10.1016/S1097-2765(00)00115-5  0.518
2001 Sriskanda V, Shuman S. A second NAD+-dependent DNA ligase (LigB) in Escherichia coli Nucleic Acids Research. 29: 4930-4934. PMID 11812821 DOI: 10.1093/Nar/29.24.4930  0.498
2001 Pei Y, Schwer B, Saiz J, Fisher RP, Shuman S. RNA triphosphatase is essential in Schizosaccharomyces pombe and Candida albicans Bmc Microbiology [Electronic Resource]. 1: 29. PMID 11737862 DOI: 10.1186/1471-2180-1-29  0.428
2001 Hausmann S, Vivarès CP, Shuman S. Characterization of the mRNA capping apparatus of the microsporidian parasite Encephalitozoon cuniculi. The Journal of Biological Chemistry. 277: 96-103. PMID 11687593 DOI: 10.1074/jbc.M109649200  0.313
2001 Ho CK, Shuman S. Trypanosoma brucei RNA triphosphatase. Antiprotozoal drug target and guide to eukaryotic phylogeny. The Journal of Biological Chemistry. 276: 46182-6. PMID 11553645 DOI: 10.1074/Jbc.M108706200  0.416
2001 Martins A, Shuman S. Mutational Analysis of Baculovirus Capping Enzyme Lef4 Delineates an Autonomous Triphosphatase Domain and Structural Determinants of Divalent Cation Specificity Journal of Biological Chemistry. 276: 45522-45529. PMID 11553638 DOI: 10.1074/Jbc.M107615200  0.529
2001 Saha N, Shuman S. Effects of alanine cluster mutations in the D12 subunit of vaccinia virus mRNA (guanine-N7) methyltransferase Virology. 287: 40-48. PMID 11504540 DOI: 10.1006/Viro.2001.1006  0.354
2001 Hausmann S, Ho CK, Schwer B, Shuman S. An Essential Function of Saccharomyces cerevisiae RNA Triphosphatase Cet1 Is to Stabilize RNA Guanylyltransferase Ceg1 against Thermal Inactivation Journal of Biological Chemistry. 276: 36116-36124. PMID 11463793 DOI: 10.1074/Jbc.M105856200  0.466
2001 Sriskanda V, Moyer RW, Shuman S. NAD+-dependent DNA ligase encoded by a eukaryotic virus. The Journal of Biological Chemistry. 276: 36100-9. PMID 11459847 DOI: 10.1074/jbc.M105643200  0.401
2001 Krogh BO, Shuman S. Vaccinia topoisomerase mutants illuminate conformational changes during closure of the protein clamp and assembly of a functional active site. The Journal of Biological Chemistry. 276: 36091-9. PMID 11441004 DOI: 10.1074/Jbc.M102609200  0.473
2001 Krogh BO, Claeboe CD, Hecht SM, Shuman S. Effect of 2'-5' phosphodiesters on DNA transesterification by vaccinia topoisomerase. The Journal of Biological Chemistry. 276: 20907-12. PMID 11399773 DOI: 10.1074/Jbc.M102312200  0.393
2001 Bisaillon M, Shuman S. Functional Groups Required for the Stability of Yeast RNA Triphosphatase in Vitro and in Vivo Journal of Biological Chemistry. 276: 30514-30520. PMID 11395522 DOI: 10.1074/Jbc.M104936200  0.45
2001 Pei Y, Hausmann S, Ho CK, Schwer B, Shuman S. The Length, Phosphorylation State, and Primary Structure of the RNA Polymerase II Carboxyl-terminal Domain Dictate Interactions with mRNA Capping Enzymes Journal of Biological Chemistry. 276: 28075-28082. PMID 11387325 DOI: 10.1074/Jbc.M102170200  0.496
2001 Changela A, Ho CK, Martins A, Shuman S, Mondragón A. Structure and mechanism of the RNA triphosphatase component of mammalian mRNA capping enzyme. The Embo Journal. 20: 2575-86. PMID 11350947 DOI: 10.1093/Emboj/20.10.2575  0.504
2001 Wang LK, Shuman S. Domain Structure and Mutational Analysis of T4 Polynucleotide Kinase Journal of Biological Chemistry. 276: 26868-26874. PMID 11335730 DOI: 10.1074/Jbc.M103663200  0.43
2001 Bisaillon M, Shuman S. Structure-Function Analysis of the Active Site Tunnel of Yeast RNA Triphosphatase Journal of Biological Chemistry. 276: 17261-17266. PMID 11279161 DOI: 10.1074/Jbc.M100980200  0.481
2001 Lehman K, Ho CK, Shuman S. Importance of homodimerization for the in vivo function of yeast RNA triphosphatase. The Journal of Biological Chemistry. 276: 14996-5002. PMID 11279098 DOI: 10.1074/Jbc.M100588200  0.716
2001 Chiu YL, Coronel E, Ho CK, Shuman S, Rana TM. HIV-1 Tat Protein Interacts with Mammalian Capping Enzyme and Stimulates Capping of TAR RNA Journal of Biological Chemistry. 276: 12959-12966. PMID 11278368 DOI: 10.1074/Jbc.M007901200  0.438
2001 Ho CK, Shuman S. A yeast-like mRNA capping apparatus in Plasmodium falciparum Proceedings of the National Academy of Sciences of the United States of America. 98: 3050-3055. PMID 11248030 DOI: 10.1073/pnas.061636198  0.313
2001 Ho CK, Gong C, Shuman S. RNA triphosphatase component of the mRNA capping apparatus of Paramecium bursaria Chlorella virus 1. Journal of Virology. 75: 1744-50. PMID 11160672 DOI: 10.1128/Jvi.75.4.1744-1750.2001  0.682
2001 Jankowsky E, Gross CH, Shuman S, Pyle AM. Active disruption of an RNA-protein interaction by a DExH/D RNA helicase. Science (New York, N.Y.). 291: 121-5. PMID 11141562 DOI: 10.1126/Science.291.5501.121  0.411
2001 Pei Y, Schwer B, Hausmann S, Shuman S. Characterization of Schizosaccharomyces pombe RNA triphospatase Nucleic Acids Research. 29: 387-396. PMID 11139608 DOI: 10.1093/Nar/29.2.387  0.491
2001 Shuman S. Analysis of topoisomerase-DNA interactions by electrophoretic mobility shift assay Methods in Molecular Biology (Clifton, N.J.). 95: 65-74. PMID 11089220 DOI: 10.1385/1-59259-057-8:65  0.36
2001 Schwer B, Lehman K, Saha N, Shuman S. Characterization of the mRNA capping apparatus of Candida albicans. The Journal of Biological Chemistry. 276: 1857-64. PMID 11035009 DOI: 10.1074/Jbc.M006072200  0.736
2000 Shuman S. Structure, mechanism, and evolution of the mRNA capping apparatus Progress in Nucleic Acid Research and Molecular Biology. 66: 1-40. PMID 11051760 DOI: 10.1016/S0079-6603(00)66025-7  0.426
2000 Cheng C, Shuman S. Recombinogenic flap ligation pathway for intrinsic repair of topoisomerase IB-induced double-strand breaks. Molecular and Cellular Biology. 20: 8059-68. PMID 11027276 DOI: 10.1128/Mcb.20.21.8059-8068.2000  0.457
2000 Schroeder SC, Schwer B, Shuman S, Bentley D. Dynamic association of capping enzymes with transcribing RNA polymerase II. Genes & Development. 14: 2435-40. PMID 11018011 DOI: 10.1101/Gad.836300  0.452
2000 Martins A, Shuman S. Mechanism of phosphoanhydride cleavage by baculovirus phosphatase Journal of Biological Chemistry. 275: 35070-35076. PMID 10954717 DOI: 10.1074/Jbc.M005748200  0.512
2000 Woodfield G, Cheng C, Shuman S, Burgin AB. Vaccinia topoisomerase and Cre recombinase catalyze direct ligation of activated DNA substrates containing a 3'-para-nitrophenyl phosphate ester. Nucleic Acids Research. 28: 3323-31. PMID 10954601 DOI: 10.1093/nar/28.17.3323  0.386
2000 Krogh BO, Shuman S. Catalytic mechanism of DNA topoisomerase IB. Molecular Cell. 5: 1035-41. PMID 10911997 DOI: 10.1016/S1097-2765(00)80268-3  0.504
2000 Sekiguchi J, Cheng C, Shuman S. Resolution of a Holliday junction by vaccinia topoisomerase requires a spacer DNA segment 3' of the CCCTT/ cleavage sites. Nucleic Acids Research. 28: 2658-63. PMID 10908320 DOI: 10.1093/Nar/28.14.2658  0.386
2000 Klemm M, Cheng C, Cassell G, Shuman S, Segall AM. Peptide inhibitors of DNA cleavage by tyrosine recombinases and topoisomerases Journal of Molecular Biology. 299: 1203-1216. PMID 10873446 DOI: 10.1006/Jmbi.2000.3829  0.429
2000 Sriskanda V, Kelman Z, Hurwitz J, Shuman S. Characterization of an ATP-dependent DNA ligase from the the thermophilic archaeon Methanobacterium thermoautotrophicum Nucleic Acids Research. 28: 2221-2228. PMID 10871342 DOI: 10.1093/Nar/28.11.2221  0.535
2000 Krogh BO, Shuman S. DNA strand transfer catalyzed by vaccinia topoisomerase: peroxidolysis and hydroxylaminolysis of the covalent protein-DNA intermediate. Biochemistry. 39: 6422-32. PMID 10828956 DOI: 10.1021/Bi000184U  0.467
2000 Ho CK, Martins A, Shuman S. A yeast-based genetic system for functional analysis of viral mRNA capping enzymes. Journal of Virology. 74: 5486-94. PMID 10823853 DOI: 10.1128/Jvi.74.12.5486-5494.2000  0.523
2000 Stivers JT, Jagadeesh GJ, Nawrot B, Stec WJ, Shuman S. Stereochemical outcome and kinetic effects of Rp- and Sp-phosphorothioate substitutions at the cleavage site of vaccinia type I DNA topoisomerase. Biochemistry. 39: 5561-72. PMID 10820030 DOI: 10.1021/Bi992429C  0.446
2000 Cheng C, Shuman S. DNA strand transfer catalyzed by vaccinia topoisomerase: ligation of DNAs containing a 3' mononucleotide overhang. Nucleic Acids Research. 28: 1893-8. PMID 10756188 DOI: 10.1093/Nar/28.9.1893  0.469
2000 Pei Y, Lehman K, Tian L, Shuman S. Characterization of Candida albicans RNA triphosphatase and mutational analysis of its active site. Nucleic Acids Research. 28: 1885-92. PMID 10756187 DOI: 10.1093/Nar/28.9.1885  0.805
2000 Jankowsky E, Gross CH, Shuman S, Pyle AM. The DExH protein NPH-II is a processive and directional motor for unwinding RNA. Nature. 403: 447-51. PMID 10667799 DOI: 10.1038/35000239  0.446
1999 Cheng C, Shuman S. Site-specific DNA transesterification by vaccinia topoisomerase: role of specific phosphates and nucleosides. Biochemistry. 38: 16599-612. PMID 10600122 DOI: 10.1021/Bi992001D  0.496
1999 Lima CD, Wang LK, Shuman S. Structure and mechanism of yeast RNA triphosphatase: An essential component of the mRNA capping apparatus Cell. 99: 533-543. PMID 10589681 DOI: 10.1016/S0092-8674(00)81541-X  0.502
1999 Ho CK, Lehman K, Shuman S. An essential surface motif (WAQKW) of yeast RNA triphosphatase mediates formation of the mRNA capping enzyme complex with RNA guanylyltransferase. Nucleic Acids Research. 27: 4671-8. PMID 10572165 DOI: 10.1093/Nar/27.24.4671  0.734
1999 Krogh BO, Cheng C, Burgin A, Shuman S. Melanoplus sanguinipes entomopoxvirus DNA topoisomerase: site-specific DNA transesterification and effects of 5'-bridging phosphorothiolates. Virology. 264: 441-51. PMID 10562506 DOI: 10.1006/Viro.1999.0022  0.47
1999 Pei Y, Ho CK, Schwer B, Shuman S. Mutational analyses of yeast RNA triphosphatases highlight a common mechanism of metal-dependent NTP hydrolysis and a means of targeting enzymes to Pre-mRNAs in vivo by fusion to the guanylyltransferase component of the capping apparatus Journal of Biological Chemistry. 274: 28865-28874. PMID 10506129 DOI: 10.1074/Jbc.274.41.28865  0.535
1999 Sriskanda V, Schwer B, Ho KC, Shuman S. Mutational analysis of Escherichia coli DNA ligase identifies amino acids required for nick-ligation in vitro and for in vivo complementation of the growth of yeast cells deleted for CDC9 and LIG4 Nucleic Acids Research. 27: 3953-3963. PMID 10497258 DOI: 10.1093/Nar/27.20.3953  0.505
1999 Lehman K, Schwer B, Ho CK, Rouzankina I, Shuman S. A conserved domain of yeast RNA triphosphatase flanking the catalytic core regulates self-association and interaction with the guanylyltransferase component of the mRNA capping apparatus. The Journal of Biological Chemistry. 274: 22668-78. PMID 10428848 DOI: 10.1074/Jbc.274.32.22668  0.724
1999 Saha N, Schwer B, Shuman S. Characterization of human, Schizosaccharomyces pombe, and Candida albicans mRNA cap methyltransferases and complete replacement of the yeast capping apparatus by mammalian enzymes Journal of Biological Chemistry. 274: 16553-16562. PMID 10347220 DOI: 10.1074/Jbc.274.23.16553  0.461
1999 Odell M, Shuman S. Footprinting of Chlorella virus DNA ligase bound at a nick in duplex DNA Journal of Biological Chemistry. 274: 14032-14039. PMID 10318816 DOI: 10.1074/Jbc.274.20.14032  0.494
1999 Ho CK, Shuman S. Distinct roles for CTD Ser-2 and Ser-5 phosphorylation in the recruitment and allosteric activation of mammalian mRNA capping enzyme. Molecular Cell. 3: 405-11. PMID 10198643 DOI: 10.1016/S1097-2765(00)80468-2  0.419
1999 Martins A, Gross CH, Shuman S. Mutational analysis of vaccinia virus nucleoside triphosphate phosphohydrolase I, a DNA-dependent ATPase of the DExH box family. Journal of Virology. 73: 1302-8. PMID 9882335 DOI: 10.1128/Jvi.73.2.1302-1308.1999  0.499
1999 Ho CK, Pei Y, Shuman S. Yeast and viral RNA 5' triphosphatases comprise a new nucleoside triphosphatase family. The Journal of Biological Chemistry. 273: 34151-6. PMID 9852075 DOI: 10.1074/Jbc.273.51.34151  0.545
1998 McCracken S, Rosonina E, Fong N, Sikes M, Beyer A, O'Hare K, Shuman S, Bentley D. Role of RNA polymerase II carboxy-terminal domain in coordinating transcription with RNA processing. Cold Spring Harbor Symposia On Quantitative Biology. 63: 301-9. PMID 10384294 DOI: 10.1101/Sqb.1998.63.301  0.431
1998 Gross CH, Shuman S. RNA 5'-triphosphatase, nucleoside triphosphatase, and guanylyltransferase activities of baculovirus LEF-4 protein Journal of Virology. 72: 10020-10028. PMID 9811740 DOI: 10.1128/Jvi.72.12.10020-10028.1998  0.488
1998 Sriskanda V, Shuman S. Mutational analysis of Chlorella virus DNA ligase: Catalytic roles of domain I and motif VI Nucleic Acids Research. 26: 4618-4625. PMID 9753729 DOI: 10.1093/Nar/26.20.4618  0.525
1998 Shuman S. Vaccinia virus DNA topoisomerase: A model eukaryotic type IB enzyme Biochimica Et Biophysica Acta - Gene Structure and Expression. 1400: 321-337. PMID 9748643 DOI: 10.1016/S0167-4781(98)00144-4  0.549
1998 Kiong Ho C, Schwer B, Shuman S. Genetic, physical, and functional interactions between the triphosphatase and guanylyltransferase components of the yeast mRNA capping apparatus Molecular and Cellular Biology. 18: 5189-5198. PMID 9710603 DOI: 10.1128/Mcb.18.9.5189  0.497
1998 Gross CH, Shuman S. Characterization of a baculovirus-encoded RNA 5'-triphosphatase Journal of Virology. 72: 7057-7063. PMID 9696798 DOI: 10.1128/Jvi.72.9.7057-7063.1998  0.493
1998 Sriskanda V, Shuman S. Specificity and fidelity of strand joining by Chlorella virus DNA ligase Nucleic Acids Research. 26: 3536-3541. PMID 9671815 DOI: 10.1093/Nar/26.15.3536  0.516
1998 Shuman S. Polynucleotide ligase activity of eukaryotic topoisomerase I Molecular Cell. 1: 741-748. PMID 9660957 DOI: 10.1016/S1097-2765(00)80073-8  0.499
1998 Gross CH, Shuman S. The nucleoside triphosphatase and helicase activities of vaccinia virus NPH-II are essential for virus replication Journal of Virology. 72: 4729-4736. PMID 9573237 DOI: 10.1128/Jvi.72.6.4729-4736.1998  0.457
1998 Cheng C, Shuman S. A catalytic domain of eukaryotic DNA topoisomerase I. The Journal of Biological Chemistry. 273: 11589-95. PMID 9565576 DOI: 10.1074/Jbc.273.19.11589  0.507
1998 Schwer B, Mao X, Shuman S. Accelerated mRNA decay in conditional mutants of yeast mRNA capping enzyme Nucleic Acids Research. 26: 2050-2057. PMID 9547258 DOI: 10.1093/Nar/26.9.2050  0.348
1998 Ho CK, Sriskanda V, McCracken S, Bentley D, Schwer B, Shuman S. The guanylyltransferase domain of mammalian mRNA capping enzyme binds to the phosphorylated carboxyl-terminal domain of RNA polymerase II. The Journal of Biological Chemistry. 273: 9577-85. PMID 9545288 DOI: 10.1074/Jbc.273.16.9577  0.522
1998 Cheng C, Kussie P, Pavletich N, Shuman S. Conservation of structure and mechanism between eukaryotic topoisomerase I and site-specific recombinases Cell. 92: 841-850. PMID 9529259 DOI: 10.1016/S0092-8674(00)81411-7  0.52
1998 Deng L, Shuman S. Vaccinia NPH-I, a DExH-box ATPase, is the energy coupling factor for mRNA transcription termination Genes and Development. 12: 538-546. PMID 9472022 DOI: 10.1101/Gad.12.4.538  0.488
1998 Schwer B, Linder P, Shuman S. Effects of deletion mutations in the yeast Ces1 protein on cell growth and morphology and on high copy suppression of mutations in mRNA capping enzyme and translation initiation factor 4A Nucleic Acids Research. 26: 803-809. PMID 9443973 DOI: 10.1093/Nar/26.3.803  0.398
1998 Sriskanda V, Shuman S. Chlorella virus DNA ligase: Nick recognition and mutational analysis Nucleic Acids Research. 26: 525-531. PMID 9421510 DOI: 10.1093/Nar/26.2.502  0.514
1998 Wittschieben J, Petersen BO, Shuman S. Replacement of the active site tyrosine of vaccinia DNA topoisomerase by glutamate, cysteine or histidine converts the enzyme into a site-specific endonuclease. Nucleic Acids Research. 26: 490-6. PMID 9421505 DOI: 10.1093/Nar/26.2.490  0.5
1997 Sekiguchi J, Shuman S. Site-specific ribonuclease activity of eukaryotic DNA topoisomerase I Molecular Cell. 1: 89-97. PMID 9659906 DOI: 10.1016/S1097-2765(00)80010-6  0.574
1997 McCracken S, Fong N, Rosonina E, Yankulov K, Brothers G, Siderovski D, Hessel A, Foster S, Shuman S, Bentley DL. 5'-Capping enzymes are targeted to pre-mRNA by binding to the phosphorylated carboxy-terminal domain of RNA polymerase II. Genes & Development. 11: 3306-18. PMID 9407024 DOI: 10.1101/Gad.11.24.3306  0.462
1997 Deng L, Shuman S. Elongation properties of vaccinia virus RNA polymerase: Pausing, slippage, 3' end addition, and termination site choice Biochemistry. 36: 15892-15899. PMID 9398322 DOI: 10.1021/Bi972037A  0.436
1997 Shuman S. Origins of mRNA identity: Capping enzymes bind to the phosphorylated C- terminal domain of RNA polymerase II Proceedings of the National Academy of Sciences of the United States of America. 94: 12758-12760. PMID 9398072 DOI: 10.1073/Pnas.94.24.12758  0.439
1997 Yu L, Martins A, Deng L, Shuman S. Structure-function analysis of the triphosphatase component of vaccinia virus mRNA capping enzyme. Journal of Virology. 71: 9837-43. PMID 9371657 DOI: 10.1128/Jvi.71.12.9837-9843.1997  0.487
1997 Sekiguchi J, Shuman S. Nick sensing by vaccinia virus DNA ligase requires a 5' phosphate at the nick and occupancy of the adenylate binding site on the enzyme Journal of Virology. 71: 9679-9684. PMID 9371633 DOI: 10.1128/Jvi.71.12.9679-9684.1997  0.495
1997 Shuman S, Bear DG, Sekiguchi J. Intramolecular synapsis of duplex DNA by vaccinia topoisomerase. The Embo Journal. 16: 6584-6589. PMID 9351838 DOI: 10.1093/Emboj/16.21.6584  0.479
1997 Sekiguchi J, Shuman S. Novobiocin inhibits vaccinia virus replication by blocking virus assembly Virology. 235: 129-137. PMID 9300044 DOI: 10.1006/Viro.1997.8684  0.371
1997 Sekiguchi J, Shuman S. Mutational analysis of vaccinia virus topoisomerase identifies residues involved in DNA binding Nucleic Acids Research. 25: 3649-3656. PMID 9278486 DOI: 10.1093/Nar/25.18.3649  0.519
1997 Wang SP, Deng L, Ho CK, Shuman S. Phylogeny of mRNA capping enzymes. Proceedings of the National Academy of Sciences of the United States of America. 94: 9573-8. PMID 9275164 DOI: 10.1073/Pnas.94.18.9573  0.551
1997 Wittschieben J, Shuman S. Mechanism of DNA transesterification by vaccinia topoisomerase: Catalytic contributions of essential residues Arg-130, Gly-132, Tyr-136 and Lys-167 Nucleic Acids Research. 25: 3001-3008. PMID 9224599 DOI: 10.1093/Nar/25.15.3001  0.539
1997 Sekiguchi J, Shuman S. Ligation of RNA-containing duplexes by vaccinia DNA ligase Biochemistry. 36: 9073-9079. PMID 9220997 DOI: 10.1021/Bi970705M  0.535
1997 Wang LK, Wittschieben J, Shuman S. Mutational analysis of 26 residues of vaccinia DNA topoisomerase identifies Ser-204 as important for DNA binding and cleavage. Biochemistry. 36: 7944-50. PMID 9201940 DOI: 10.1021/Bi970498Q  0.527
1997 Sekiguchi J, Cheng C, Shuman S. Kinetic analysis of DNA and RNA strand transfer reactions catalyzed by vaccinia topoisomerase. The Journal of Biological Chemistry. 272: 15721-8. PMID 9188465 DOI: 10.1074/Jbc.272.25.15721  0.525
1997 Wang SP, Shuman S. Structure-function analysis of the mRNA cap methyltransferase of Saccharomyces cerevisiae Journal of Biological Chemistry. 272: 14683-14689. PMID 9169431 DOI: 10.1074/Jbc.272.23.14683  0.465
1997 Håkansson K, Doherty AJ, Shuman S, Wigley DB. X-ray crystallography reveals a large conformational change during guanyl transfer by mRNA capping enzymes. Cell. 89: 545-53. PMID 9160746 DOI: 10.1016/S0092-8674(00)80236-6  0.385
1997 Petersen B, Shuman S. DNA strand transfer reactions catalyzed by vaccinia topoisomerase: Hydrolysis and glycerololysis of the covalent protein-DNA intermediate Nucleic Acids Research. 25: 2091-2097. PMID 9153307 DOI: 10.1093/Nar/25.11.2091  0.496
1997 Petersen BO, Hall RL, Moyer RW, Shuman S. Characterization of a DNA topoisomerase encoded by Amsacta moore entomopoxvirus. Virology. 230: 197-206. PMID 9143275 DOI: 10.1006/Viro.1997.8495  0.471
1997 Wang LK, Shuman S. Deletions at the carboxyl terminus of vaccinia DNA topoisomerase affect DNA binding and enhance distributivity in DNA relaxation Biochemistry. 36: 3909-3916. PMID 9092821 DOI: 10.1021/Bi962754P  0.5
1997 Cheng C, Wang LK, Sekiguchi J, Shuman S. Mutational analysis of 39 residues of vaccinia DNA topoisomerase identifies Lys-220, Arg-223, and Asn-228 as important for covalent catalysis. The Journal of Biological Chemistry. 272: 8263-9. PMID 9079646 DOI: 10.1074/Jbc.272.13.8263  0.514
1997 Cheng C, Shuman S. Characterization of an ATP-dependent DNA ligase encoded by Haemophilus influenzae. Nucleic Acids Research. 25: 1369-74. PMID 9060431 DOI: 10.1093/Nar/25.7.1369  0.516
1997 Ho CK, Van Etten JL, Shuman S. Characterization of an ATP-dependent DNA ligase encoded by Chlorella virus PBCV-1. Journal of Virology. 71: 1931-7. PMID 9032324 DOI: 10.1128/Jvi.71.3.1931-1937.1997  0.533
1997 Petersen B, Shuman S. Histidine 265 is important for covalent catalysis by vaccinia topoisomerase and is conserved in all eukaryotic type I enzymes Journal of Biological Chemistry. 272: 3891-3896. PMID 9020090 DOI: 10.1074/Jbc.272.7.3891  0.487
1997 Sekiguchi J, Shuman S. Domain structure of vaccinia DNA ligase Nucleic Acids Research. 25: 727-734. PMID 9016621 DOI: 10.1093/Nar/25.4.727  0.488
1997 Deng L, Shuman S. Transcription termination by vaccinia RNA polymerase entails recognition of specific phosphates in the nascent RNA Journal of Biological Chemistry. 272: 695-698. PMID 8995314 DOI: 10.1074/Jbc.272.1.695  0.47
1996 Gross CH, Shuman S. Vaccinia virions lacking the RNA helicase nucleoside triphosphate phosphohydrolase II are defective in early transcription Journal of Virology. 70: 8549-8557. PMID 8970979  0.378
1996 Petersen BO, Wittschieben J, Shuman S. Mutations within a conserved region of vaccinia topoisomerase affect the DNA cleavage-religation equilibrium. Journal of Molecular Biology. 263: 181-95. PMID 8913300 DOI: 10.1006/Jmbi.1996.0568  0.474
1996 Deng L, Shuman S. An ATPase component of the transcription elongation complex is required for factor-dependent transcription termination by vaccinia RNA polymerase Journal of Biological Chemistry. 271: 29386-29392. PMID 8910603 DOI: 10.1074/Jbc.271.46.29386  0.419
1996 Schwer B, Shuman S. Multicopy suppressors of temperature-sensitive mutations of yeast mRNA capping enzyme Gene Expression. 5: 331-344. PMID 8836740  0.377
1996 Shuman S. Closing the gap on DNA ligase Structure. 4: 653-656. PMID 8805556 DOI: 10.1016/S0969-2126(96)00070-6  0.463
1996 Ho CK, Van Etten JL, Shuman S. Expression and characterization of an RNA capping enzyme encoded by Chlorella virus PBCV-1. Journal of Virology. 70: 6658-64. PMID 8794301 DOI: 10.1128/Jvi.70.10.6658-6664.1996  0.494
1996 Yu L, Shuman S. Mutational analysis of the RNA triphosphatase component of vaccinia virus mRNA capping enzyme Journal of Virology. 70: 6162-6168. PMID 8709242  0.379
1996 Deng L, Hagler J, Shuman S. Factor-dependent release of nascent RNA by ternary complexes of vaccinia RNA polymerase. The Journal of Biological Chemistry. 271: 19556-62. PMID 8702649 DOI: 10.1074/Jbc.271.32.19556  0.441
1996 Sekiguchi J, Shuman S. Covalent DNA binding by vaccinia topoisomerase results in unpairing of the thymine base 5' of the scissile bond Journal of Biological Chemistry. 271: 19436-19442. PMID 8702632 DOI: 10.1074/Jbc.271.32.19436  0.443
1996 Sekiguchi J, Shuman S. Identification of contacts between topoisomerase I and its target DNA by site-specific photocrosslinking Embo Journal. 15: 3448-3457. PMID 8670847 DOI: 10.1002/J.1460-2075.1996.Tb00711.X  0.512
1996 Gross CH, Shuman S. Vaccinia virus RNA helicase: Nucleic acid specificity in duplex unwinding Journal of Virology. 70: 2615-2619. PMID 8642695  0.443
1996 Ho CK, Shuman S. Mutational analysis of the vaccinia virus E3 protein defines amino acid residues involved in E3 binding to double-stranded RNA Journal of Virology. 70: 2611-2614. PMID 8642694  0.35
1996 Mao X, Shuman S. Vaccinia virus mRNA (guanine-7-)methyltransferase: Mutational effects on cap methylation and AdoHcy-dependent photo-cross-linking of the cap to the methyl acceptor site Biochemistry. 35: 6900-6910. PMID 8639642 DOI: 10.1021/Bi960221A  0.422
1996 Gross CH, Shuman S. The QRxGRxGRxxxG motif of the vaccinia virus DExH box RNA helicase NPH-II is required for ATP hydrolysis and RNA unwinding but not for RNA binding Journal of Virology. 70: 1706-1713. PMID 8627691  0.405
1996 Ho CK, Shuman S. Physical and functional characterization of the double-stranded RNA binding protein encoded by the vaccinia virus E3 gene Virology. 217: 272-284. PMID 8599212 DOI: 10.1006/Viro.1996.0114  0.423
1996 Sekiguchi J, Seeman NC, Shuman S. Resolution of Holliday junctions by eukaryotic DNA topoisomerase I. Proceedings of the National Academy of Sciences of the United States of America. 93: 785-9. PMID 8570635 DOI: 10.1073/Pnas.93.2.785  0.457
1996 Sekiguchi J, Stivers JT, Mildvan AS, Shuman S. Mechanism of inhibition of vaccinia DNA topoisomerase by novobiocin and coumermycin. The Journal of Biological Chemistry. 271: 2313-22. PMID 8567695 DOI: 10.1074/Jbc.271.4.2313  0.439
1996 Mao X, Schwer B, Shuman S. Mutational analysis of the Saccharomyces cerevisiae ABD1 gene: Cap methyltransferase activity is essential for cell growth Molecular and Cellular Biology. 16: 475-480. PMID 8552073 DOI: 10.1128/Mcb.16.2.475  0.442
1995 Shuman S, Schwer B. RNA capping enzyme and DNA ligase: A superfamily of covalent nucleotidyl transferases Molecular Microbiology. 17: 405-410. PMID 8559059 DOI: 10.1111/J.1365-2958.1995.Mmi_17030405.X  0.535
1995 Shuman S. Vaccinia virus DNA ligase: Specificity, fidelity, and inhibition Biochemistry. 34: 16138-16147. PMID 8519771 DOI: 10.1021/Bi00049A029  0.506
1995 Shuman S. Capping enzyme in eukaryotic mRNA synthesis Progress in Nucleic Acid Research and Molecular Biology. 50: 101-129. PMID 7754031 DOI: 10.1016/S0079-6603(08)60812-0  0.452
1995 Luo Y, Mao X, Deng L, Cong P, Shuman S. The D1 and D12 subunits are both essential for the transcription termination factor activity of vaccinia virus capping enzyme. Journal of Virology. 69: 3852-6. PMID 7745734 DOI: 10.1128/Jvi.69.6.3852-3856.1995  0.44
1995 Sekiguchi J, Shuman S. Proteolytic footprinting of vaccinia topoisomerase bound to DNA Journal of Biological Chemistry. 270: 11636-11645. PMID 7744804 DOI: 10.1074/Jbc.270.19.11636  0.513
1995 Kane EM, Shuman S. Adenosine N1-oxide inhibits vaccinia virus replication by blocking translation of viral early mRNAs. Journal of Virology. 69: 6352-8. PMID 7666536 DOI: 10.1128/Jvi.69.10.6352-6358.1995  0.361
1995 Shuman S, Ru XM. Mutational analysis of vaccinia DNA ligase defines residues essential for covalent catalysis Virology. 211: 73-83. PMID 7645238 DOI: 10.1006/Viro.1995.1380  0.555
1995 Mao X, Schwer B, Shuman S. Yeast mRNA cap methyltransferase is a 50-kilodalton protein encoded by an essential gene Molecular and Cellular Biology. 15: 4167-4174. PMID 7623811 DOI: 10.1128/Mcb.15.8.4167  0.423
1995 Gross CH, Shuman S. Mutational analysis of vaccinia virus nucleoside triphosphate phosphohydrolase II, a DExH box RNA helicase Journal of Virology. 69: 4727-4736. PMID 7609038  0.402
1995 Cong P, Shuman S. Mutational analysis of mRNA capping enzyme identifies amino acids involved in GTP binding, enzyme-guanylate formation, and GMP transfer to RNA Molecular and Cellular Biology. 15: 6222-6231. PMID 7565775 DOI: 10.1128/Mcb.15.11.6222  0.532
1994 Stivers JT, Shuman S, Mildvan AS. Vaccinia DNA topoisomerase I: single-turnover and steady-state kinetic analysis of the DNA strand cleavage and ligation reactions. Biochemistry. 33: 327-39. PMID 8286354 DOI: 10.1021/Bi00167A043  0.474
1994 Schwer B, Shuman S. Mutational analysis of yeast mRNA capping enzyme Proceedings of the National Academy of Sciences of the United States of America. 91: 4328-4332. PMID 8183907 DOI: 10.1073/Pnas.91.10.4328  0.529
1994 Shuman S, Liu Y, Schwer B. Covalent catalysis in nucleotidyl transfer reactions: Essential motifs in Saccharomyces cerevisiae RNA capping enzyme are conserved in Schizosaccharomyces pombe and viral capping enzymes and among polynucleotide ligases Proceedings of the National Academy of Sciences of the United States of America. 91: 12046-12050. PMID 7991582 DOI: 10.1073/Pnas.91.25.12046  0.478
1994 Sekiguchi J, Shuman S. Vaccinia topoisomerase binds circumferentially to DNA Journal of Biological Chemistry. 269: 31731-31734. PMID 7989346  0.376
1994 Wittschieben J, Shuman S. Mutational analysis of vaccinia DNA topoisomerase defines amino acid residues essential for covalent catalysis Journal of Biological Chemistry. 269: 29978-29983. PMID 7961997  0.387
1994 Mao X, Shuman S. Intrinsic RNA (Guanine-7) Methyltransferase Activity of the Vaccinia Virus Capping Enzyme D1 Subunit Is Stimulated by the D12 Subunit: Identification of Amino Acid Residues in the D1 Protein Required for Subunit Association and Methyl Group Transfer Journal of Biological Chemistry. 269: 24472-24479. PMID 7929111  0.304
1994 Sekiguchi J, Shuman S. Requirements for noncovalent binding of vaccinia topoisomerase I to duplex DNA Nucleic Acids Research. 22: 5360-5365. PMID 7816626 DOI: 10.1093/Nar/22.24.5360  0.466
1994 Shuman S. Novel approach to molecular cloning and polynucleotide synthesis using vaccinia DNA topoisomerase Journal of Biological Chemistry. 269: 32678-32684. PMID 7798275  0.365
1993 Shuman S. Vaccinia virus RNA helicase: Directionality and substrate specificity Journal of Biological Chemistry. 268: 11798-11802. PMID 8505308  0.419
1993 Luo Y, Shuman S. RNA binding properties of vaccinia virus capping enzyme Journal of Biological Chemistry. 268: 21253-21262. PMID 8407963  0.385
1993 Kane EM, Shuman S. Vaccinia virus morphogenesis is blocked by a temperature-sensitive mutation in the I7 gene that encodes a virion component. Journal of Virology. 67: 2689-98. PMID 8386272 DOI: 10.1128/Jvi.67.5.2689-2698.1993  0.373
1993 Cong P, Shuman S. Covalent catalysis in nucleotidyl transfer: A KTDG motif essential for enzyme-GMP complex formation by mRNA capping enzyme is conserved at the active sites of RNA and DNA ligases Journal of Biological Chemistry. 268: 7256-7260. PMID 8385101  0.438
1993 Shuman S, Turner J. Site-specific interaction of vaccinia virus topoisomerase I with base and sugar moieties in duplex DNA Journal of Biological Chemistry. 268: 18943-18950. PMID 7689562  0.45
1993 Hagler J, Shuman S. Nascent RNA cleavage by purified ternary complexes of vaccinia RNA polymerase Journal of Biological Chemistry. 268: 2166-2173. PMID 7678416  0.349
1992 Hagler J, Shuman S. Stability of ternary transcription complexes of vaccinia virus RNA polymerase at promoter-proximal positions Journal of Biological Chemistry. 267: 7644-7654. PMID 1559999  0.375
1992 Hagler J, Shuman S. A freeze-frame view of eukaryotic transcription during elongation and capping of nascent mRNA Science. 255: 983-986. PMID 1546295 DOI: 10.1126/Science.1546295  0.458
1992 Kane EM, Shuman S. Temperature-sensitive mutations in the vaccinia virus H4 gene encoding a component of the virion RNA polymerase. Journal of Virology. 66: 5752-62. PMID 1527841 DOI: 10.1128/Jvi.66.10.5752-5762.1992  0.398
1992 Hagler J, Shuman S. Structural analysis of ternary complexes of vaccinia RNA polymerase Proceedings of the National Academy of Sciences of the United States of America. 89: 10099-10103. PMID 1438198  0.434
1992 Hagler J, Shuman S. Ternary complex formation by vaccinia virus RNA polymerase at an early viral promoter: Analysis by native gel electrophoresis Journal of Virology. 66: 2982-2989. PMID 1373199  0.369
1992 Shuman S. Vaccinia virus RNA helicase: An essential enzyme related to the DE-H family of RNA-dependent NTPases Proceedings of the National Academy of Sciences of the United States of America. 89: 10935-10939. PMID 1332061 DOI: 10.1073/Pnas.89.22.10935  0.47
1992 Shuman S. Two classes of DNA end-joining reactions catalyzed by vaccinia topoisomerase I Journal of Biological Chemistry. 267: 16755-16758. PMID 1324909  0.366
1992 Gong P, Shuman S. Methyltransferase and subunit association domains of vaccinia virus mRNA capping enzyme Journal of Biological Chemistry. 267: 16424-16429. PMID 1322901  0.39
1992 Morham SG, Shuman S. Covalent and noncovalent DNA binding by mutants of vaccinia DNA topoisomerse I Journal of Biological Chemistry. 267: 15984-15992. PMID 1322412  0.425
1992 Shuman S. DNA strand transfer reactions catalyzed by vaccinia topoisomerase I Journal of Biological Chemistry. 267: 8620-8627. PMID 1314832  0.377
1991 Luo Y, Shuman S. Antitermination of vaccinia virus early transcription: Possible role of RNA secondary structure Virology. 185: 432-436. PMID 1926785 DOI: 10.1016/0042-6822(91)90793-B  0.456
1991 Shuman S. Site-specific DNA cleavage by vaccinia virus DNA topoisomerase I: Role of nucleotide sequence and DNA secondary structure Journal of Biological Chemistry. 266: 1796-1803. PMID 1846364  0.376
1991 Shuman S. Recombination mediated by vaccinia virus DNA topoisomerase I in Escherichia coli is sequence specific Proceedings of the National Academy of Sciences of the United States of America. 88: 10104-10108. PMID 1658796 DOI: 10.1073/Pnas.88.22.10104  0.489
1991 Shuman S. Site-specific interaction of vaccinia virus topoisomerase I with duplex DNA minimal DNA substrate for strand cleavage in vitro Journal of Biological Chemistry. 266: 11372-11379. PMID 1645733  0.425
1990 Shuman S, Prescott J. Specific DNA cleavage and binding by vaccinia virus DNA topoisomerase I Journal of Biological Chemistry. 265: 17826-17836. PMID 2170398  0.376
1990 Shuman S, Moss B. Purification and use of vaccinia virus messenger RNA capping enzyme Methods in Enzymology. 181: 170-180. PMID 2166212 DOI: 10.1016/0076-6879(90)81119-F  0.448
1990 Shuman S, Morham SG. Domain structure of vaccinia virus mRNA capping enzyme: Activity of the Mr 95,000 subunit expressed in Escherichia coli Journal of Biological Chemistry. 265: 11967-11972. PMID 2164023  0.328
1990 Shuman S. Catalytic activity of vaccinia mRNA capping enzyme subunits coexpressed in Escherichia coli Journal of Biological Chemistry. 265: 11960-11966. PMID 2164022  0.385
1989 Shuman S, Moss B. Bromouridine triphosphate inhibits transcription termination and mRNA release by vaccinia virions Journal of Biological Chemistry. 264: 21356-21360. PMID 2592381  0.31
1989 Shuman S, Kane EM, Morham SG. Mapping the active-site tyrosine of vaccinia virus DNA topoisomerase I. Proceedings of the National Academy of Sciences of the United States of America. 86: 9793-7. PMID 2557629 DOI: 10.1073/Pnas.86.24.9793  0.512
1989 Shuman S. Vaccinia DNA topoisomerase I promotes illegitimate recombination in Escherichia coli Proceedings of the National Academy of Sciences of the United States of America. 86: 3489-3493. PMID 2542933 DOI: 10.1073/Pnas.86.10.3489  0.476
1989 Shuman S. Functional domains of vaccinia virus mRNA capping enzyme. Analysis by limited tryptic digestion Journal of Biological Chemistry. 264: 9690-9695. PMID 2542318  0.372
1988 Shuman S, Moss B. Vaccinia virus poly(A) polymerase. Specificity for nucleotides and nucleotide analogs Journal of Biological Chemistry. 263: 8405-8412. PMID 2836422  0.361
1988 Shuman S, Moss B. Factor-dependent transcription termination by vaccinia virus RNA polymerase. Evidence that the cis-acting termination signal is in nascent RNA Journal of Biological Chemistry. 263: 6220-6225. PMID 2834368  0.384
1987 Shuman S, Moss B. Identification of a vaccinia virus gene encoding a type I DNA topoisomerase Proceedings of the National Academy of Sciences of the United States of America. 84: 7478-7482. PMID 2823264 DOI: 10.1073/Pnas.84.21.7478  0.388
1982 Shuman S. RNA capping by HeLa cell RNA guanylyltransferase. Characterization of a covalent protein-guanylate intermediate Journal of Biological Chemistry. 257: 7237-7245. PMID 6282835  0.34
1982 Shuman S, Hurwitz J. 9 Capping Enzyme Enzymes. 15: 245-265. DOI: 10.1016/S1874-6047(08)60281-4  0.469
1981 Shuman S, Hurwitz J. Mechanism of mRNA capping by vaccinia virus guanylyltransferase: Characterization of an enzyme-guanylate intermediate Proceedings of the National Academy of Sciences of the United States of America. 78: 187-191. PMID 6264433 DOI: 10.1073/Pnas.78.1.187  0.45
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