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James Herschel Hurley - Publications

1998-2013 Laboratory of Molecular Biology National Institute of Diabetes and Digestive and Kidney Diseases 
 2013- Molecular & Cell Biology University of California, Berkeley, Berkeley, CA 
protein-membrane interaction

202 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2021 Chang C, Jensen LE, Hurley JH. Autophagosome biogenesis comes out of the black box. Nature Cell Biology. PMID 33903736 DOI: 10.1038/s41556-021-00669-y  1
2021 Chang C, Shi X, Jensen LE, Yokom AL, Fracchiolla D, Martens S, Hurley JH. Reconstitution of cargo-induced LC3 lipidation in mammalian selective autophagy. Science Advances. 7. PMID 33893090 DOI: 10.1126/sciadv.abg4922  1
2021 Klionsky DJ, Abdel-Aziz AK, Abdelfatah S, Abdellatif M, Abdoli A, Abel S, Abeliovich H, Abildgaard MH, Abudu YP, Acevedo-Arozena A, Adamopoulos IE, Adeli K, Adolph TE, Adornetto A, Aflaki E, ... ... Hurley JH, et al. Guidelines for the use and interpretation of assays for monitoring autophagy (4th edition). Autophagy. 1-382. PMID 33634751 DOI: 10.1080/15548627.2020.1797280  1
2021 Flower TG, Hurley JH. Crystallographic molecular replacement using an in silico-generated search model of SARS-CoV-2 ORF8. Protein Science : a Publication of the Protein Society. PMID 33625752 DOI: 10.1002/pro.4050  0.64
2021 Flower TG, Hurley JH. Crystallographic molecular replacement using an -generated search model of SARS-CoV-2 ORF8. Biorxiv : the Preprint Server For Biology. PMID 33442695 DOI: 10.1101/2021.01.05.425441  0.64
2021 Flower TG, Buffalo CZ, Hooy RM, Allaire M, Ren X, Hurley JH. Structure of SARS-CoV-2 ORF8, a rapidly evolving immune evasion protein. Proceedings of the National Academy of Sciences of the United States of America. 118. PMID 33361333 DOI: 10.1073/pnas.2021785118  1
2020 Painter MM, Zimmerman GE, Merlino MS, Robertson AW, Terry VH, Ren X, McLeod MR, Gomez-Rodriguez L, Garcia KA, Leonard JA, Leopold KE, Neevel AJ, Lubow J, Olson E, Piechocka-Trocha A, ... ... Hurley JH, et al. Concanamycin A counteracts HIV-1 Nef to enhance immune clearance of infected primary cells by cytotoxic T lymphocytes. Proceedings of the National Academy of Sciences of the United States of America. PMID 32900948 DOI: 10.1073/Pnas.2008615117  1
2020 Flower TG, Buffalo CZ, Hooy RM, Allaire M, Ren X, Hurley JH. Structure of SARS-CoV-2 ORF8, a rapidly evolving coronavirus protein implicated in immune evasion. Biorxiv : the Preprint Server For Biology. PMID 32869027 DOI: 10.1101/2020.08.27.270637  1
2020 Fromm SA, Lawrence RE, Hurley JH. Structural mechanism for amino acid-dependent Rag GTPase nucleotide state switching by SLC38A9. Nature Structural & Molecular Biology. PMID 32868926 DOI: 10.1038/s41594-020-0490-9  0.32
2020 Su MY, Fromm SA, Zoncu R, Hurley JH. Structure of the C9orf72 ARF GAP complex that is haploinsufficient in ALS and FTD. Nature. PMID 32848248 DOI: 10.1038/S41586-020-2633-X  1
2020 Shi X, Chang C, Yokom AL, Jensen LE, Hurley JH. The autophagy adaptor NDP52 and the FIP200 coiled-coil allosterically activate ULK1 complex membrane recruitment. Elife. 9. PMID 32773036 DOI: 10.7554/eLife.59099  1
2020 Bhargava HK, Tabata K, Byck JM, Hamasaki M, Farrell DP, Anishchenko I, DiMaio F, Im YJ, Yoshimori T, Hurley JH. Structural basis for autophagy inhibition by the human Rubicon-Rab7 complex. Proceedings of the National Academy of Sciences of the United States of America. PMID 32632011 DOI: 10.1073/Pnas.2008030117  1
2020 Shi X, Yokom AL, Wang C, Young LN, Youle RJ, Hurley JH. ULK complex organization in autophagy by a C-shaped FIP200 N-terminal domain dimer. The Journal of Cell Biology. 219. PMID 32516362 DOI: 10.1083/Jcb.201911047  1
2020 Fracchiolla D, Chang C, Hurley JH, Martens S. A PI3K-WIPI2 positive feedback loop allosterically activates LC3 lipidation in autophagy. The Journal of Cell Biology. 219. PMID 32437499 DOI: 10.1083/jcb.201912098  1
2020 Flower TG, Takahashi Y, Hudait A, Rose K, Tjahjono N, Pak AJ, Yokom AL, Liang X, Wang HG, Bouamr F, Voth GA, Hurley JH. A helical assembly of human ESCRT-I scaffolds reverse-topology membrane scission. Nature Structural & Molecular Biology. PMID 32424346 DOI: 10.1038/S41594-020-0426-4  0.64
2020 Prinz WA, Hurley JH. A firehose for phospholipids. The Journal of Cell Biology. 219. PMID 32339216 DOI: 10.1083/jcb.202003132  1
2019 Lawrence RE, Fromm SA, Fu Y, Yokom AL, Kim DJ, Thelen AM, Young LN, Lim CY, Samelson AJ, Hurley JH, Zoncu R. Structural mechanism of a Rag GTPase activation checkpoint by the lysosomal folliculin complex. Science (New York, N.Y.). PMID 31672913 DOI: 10.1126/Science.Aax0364  1
2019 Young LN, Goerdeler F, Hurley JH. Structural pathway for allosteric activation of the autophagic PI 3-kinase complex I. Proceedings of the National Academy of Sciences of the United States of America. PMID 31591221 DOI: 10.1073/Pnas.1911612116  1
2019 Buffalo CZ, Iwamoto Y, Hurley JH, Ren X. How HIV Nef Proteins Hijack Membrane Traffic to Promote Infection. Journal of Virology. PMID 31578291 DOI: 10.1128/Jvi.01322-19  1
2019 Horst BG, Yokom AL, Rosenberg DJ, Morris KL, Hammel M, Hurley JH, Marletta MA. Allosteric activation of the nitric oxide receptor soluble guanylate cyclase mapped by cryo-electron microscopy. Elife. 8. PMID 31566566 DOI: 10.7554/Elife.50634  1
2019 Buffalo CZ, Stürzel CM, Heusinger E, Kmiec D, Kirchhoff F, Hurley JH, Ren X. Structural Basis for Tetherin Antagonism as a Barrier to Zoonotic Lentiviral Transmission. Cell Host & Microbe. PMID 31447307 DOI: 10.1016/J.Chom.2019.08.002  1
2019 Turco E, Witt M, Abert C, Bock-Bierbaum T, Su MY, Trapannone R, Sztacho M, Danieli A, Shi X, Zaffagnini G, Gamper A, Schuschnig M, Fracchiolla D, Bernklau D, Romanov J, ... ... Hurley JH, et al. How RB1CC1/FIP200 claws its way to autophagic engulfment of SQSTM1/p62-ubiquitin condensates. Autophagy. PMID 31066340 DOI: 10.1080/15548627.2019.1615306  1
2019 Chang C, Young LN, Hurley JH. The BARA Necessities of PtdIns 3-Kinase Activation in Autophagy. Autophagy. PMID 30894086 DOI: 10.1080/15548627.2019.1596501  1
2019 Turco E, Witt M, Abert C, Bock-Bierbaum T, Su MY, Trapannone R, Sztacho M, Danieli A, Shi X, Zaffagnini G, Gamper A, Schuschnig M, Fracchiolla D, Bernklau D, Romanov J, ... ... Hurley JH, et al. FIP200 Claw Domain Binding to p62 Promotes Autophagosome Formation at Ubiquitin Condensates. Molecular Cell. PMID 30853400 DOI: 10.1016/J.Molcel.2019.01.035  1
2019 Brier LW, Ge L, Stjepanovic G, Thelen AM, Hurley J, Schekman R. Regulation of LC3 Lipidation by the Autophagy-Specific Class III Phosphatidylinostitol-3 Kinase Complex. Molecular Biology of the Cell. mbcE18110743. PMID 30811270 DOI: 10.1091/Mbc.E18-11-0743  1
2018 Chang C, Young LN, Morris KL, von Bülow S, Schöneberg J, Yamamoto-Imoto H, Oe Y, Yamamoto K, Nakamura S, Stjepanovic G, Hummer G, Yoshimori T, Hurley JH. Bidirectional Control of Autophagy by BECN1 BARA Domain Dynamics. Molecular Cell. PMID 30581147 DOI: 10.1016/J.Molcel.2018.10.035  1
2018 Schöneberg J, Pavlin MR, Yan S, Righini M, Lee IH, Carlson LA, Bahrami AH, Goldman DH, Ren X, Hummer G, Bustamante C, Hurley JH. ATP-dependent force generation and membrane scission by ESCRT-III and Vps4. Science (New York, N.Y.). 362: 1423-1428. PMID 30573630 DOI: 10.1126/Science.Aat1839  1
2018 Schulze-Gahmen U, Hurley JH. Structural mechanism for HIV-1 TAR loop recognition by Tat and the super elongation complex. Proceedings of the National Academy of Sciences of the United States of America. 115: 12973-12978. PMID 30514815 DOI: 10.1073/pnas.1806438115  0.56
2018 Lawrence RE, Cho KF, Rappold R, Thrun A, Tofaute M, Kim DJ, Moldavski O, Hurley JH, Zoncu R. A nutrient-induced affinity switch controls mTORC1 activation by its Rag GTPase-Ragulator lysosomal scaffold. Nature Cell Biology. PMID 30061680 DOI: 10.1038/S41556-018-0148-6  1
2018 Morris KL, Buffalo CZ, Stürzel CM, Heusinger E, Kirchhoff F, Ren X, Hurley JH. HIV-1 Nefs Are Cargo-Sensitive AP-1 Trimerization Switches in Tetherin Downregulation. Cell. 174: 659-671.e14. PMID 30053425 DOI: 10.1016/J.Cell.2018.07.004  1
2018 Lin MG, Schöneberg J, Davies CW, Ren X, Hurley JH. The dynamic Atg13-free conformation of the Atg1 EAT domain is required for phagophore expansion. Molecular Biology of the Cell. PMID 29540529 DOI: 10.1091/Mbc.E17-04-0258  1
2018 Gardner BM, Castanzo DT, Chowdhury S, Stjepanovic G, Stefely MS, Hurley JH, Lander GC, Martin A. The peroxisomal AAA-ATPase Pex1/Pex6 unfolds substrates by processive threading. Nature Communications. 9: 135. PMID 29321502 DOI: 10.1038/S41467-017-02474-4  1
2017 Stjepanovic G, Baskaran S, Lin MG, Hurley JH. Unveiling the role of VPS34 kinase domain dynamics in regulation of the autophagic PI3K complex. Molecular & Cellular Oncology. 4: e1367873. PMID 29209653 DOI: 10.1080/23723556.2017.1367873  1
2017 Su MY, Morris KL, Kim DJ, Fu Y, Lawrence R, Stjepanovic G, Zoncu R, Hurley JH. Hybrid Structure of the RagA/C-Ragulator mTORC1 Activation Complex. Molecular Cell. PMID 29107538 DOI: 10.1016/J.Molcel.2017.10.016  1
2017 Bahrami AH, Lin MG, Ren X, Hurley JH, Hummer G. Scaffolding the cup-shaped double membrane in autophagy. Plos Computational Biology. 13: e1005817. PMID 29065154 DOI: 10.1371/Journal.Pcbi.1005817  1
2017 Stjepanovic G, Baskaran S, Lin MG, Hurley JH. Vps34 Kinase Domain Dynamics Regulate the Autophagic PI 3-Kinase Complex. Molecular Cell. 67: 528-534.e3. PMID 28757208 DOI: 10.1016/J.Molcel.2017.07.003  1
2017 Mandadapu KK, Hurley JH. Friction at the BAR Leads to Membrane Breakup. Cell. 170: 14-16. PMID 28666116 DOI: 10.1016/J.Cell.2017.06.027  0.01
2017 Hurley JH, Young LN. Mechanisms of Autophagy Initiation. Annual Review of Biochemistry. PMID 28301741 DOI: 10.1146/Annurev-Biochem-061516-044820  1
2017 Qi S, Li Z, Schulze-Gahmen U, Stjepanovic G, Zhou Q, Hurley JH. Structural basis for ELL2 and AFF4 activation of HIV-1 proviral transcription. Nature Communications. 8: 14076. PMID 28134250 DOI: 10.1038/Ncomms14076  1
2017 Tooze SA, Hurley JH. Molecular Mechanisms of Autophagy-Part B. Journal of Molecular Biology. PMID 28087262 DOI: 10.1016/j.jmb.2017.01.009  0.01
2016 Schulze-Gahmen U, Echeverria I, Stjepanovic G, Bai Y, Lu H, Schneidman-Duhovny D, Doudna JA, Zhou Q, Sali A, Hurley JH. Insights into HIV-1 proviral transcription from the structure and dynamics of the Tat:AFF4:P-TEFb:TAR complex. Elife. 5. PMID 27731797 DOI: 10.7554/Elife.15910  1
2016 Schöneberg J, Lee IH, Iwasa JH, Hurley JH. Reverse-topology membrane scission by the ESCRT proteins. Nature Reviews. Molecular Cell Biology. PMID 27703243 DOI: 10.1038/Nrm.2016.121  1
2016 Hurley JH, Nogales E. Next-generation electron microscopy in autophagy research. Current Opinion in Structural Biology. 41: 211-216. PMID 27614295 DOI: 10.1016/J.Sbi.2016.08.006  0.48
2016 Young LN, Cho K, Lawrence R, Zoncu R, Hurley JH. Dynamics and architecture of the NRBF2-containing phosphatidylinositol 3-kinase complex I of autophagy. Proceedings of the National Academy of Sciences of the United States of America. PMID 27385829 DOI: 10.1073/Pnas.1603650113  1
2016 Carlson LA, Bai Y, Keane SC, Doudna JA, Hurley JH. Reconstitution of selective HIV-1 RNA packaging in vitro by membrane-bound Gag assemblies. Elife. 5. PMID 27343348 DOI: 10.7554/Elife.14663  1
2016 Hurley JH. Editorial overview: Molecular mechanisms of autophagy - part I. Journal of Molecular Biology. PMID 27037195 DOI: 10.1016/j.jmb.2016.03.019  1
2016 Hershey DM, Ren X, Melnyk RA, Browne PJ, Ozyamak E, Jones SR, Chang MC, Hurley JH, Komeili A. MamO Is a Repurposed Serine Protease that Promotes Magnetite Biomineralization through Direct Transition Metal Binding in Magnetotactic Bacteria. Plos Biology. 14: e1002402. PMID 26981620 DOI: 10.1371/Journal.Pbio.1002402  1
2016 Lin MG, Hurley JH. Structure and function of the ULK1 complex in autophagy. Current Opinion in Cell Biology. 39: 61-68. PMID 26921696 DOI: 10.1016/  1
2016 Klionsky DJ, Abdelmohsen K, Abe A, Abedin MJ, Abeliovich H, Acevedo Arozena A, Adachi H, Adams CM, Adams PD, Adeli K, Adhihetty PJ, Adler SG, Agam G, Agarwal R, Aghi MK, ... ... Hurley JH, et al. Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition). Autophagy. 12: 1-222. PMID 26799652 DOI: 10.1080/15548627.2015.1100356  0.01
2015 Lee IH, Kai H, Carlson LA, Groves JT, Hurley JH. Negative membrane curvature catalyzes nucleation of endosomal sorting complex required for transport (ESCRT)-III assembly. Proceedings of the National Academy of Sciences of the United States of America. PMID 26668364 DOI: 10.1073/Pnas.1518765113  1
2015 Carlson LA, Shen QT, Pavlin MR, Hurley JH. ESCRT Filaments as Spiral Springs. Developmental Cell. 35: 397-398. PMID 26609952 DOI: 10.1016/J.Devcel.2015.11.007  1
2015 Shen QT, Ren X, Zhang R, Lee IH, Hurley JH. HIV-1 Nef hijacks clathrin coats by stabilizing AP-1:Arf1 polygons. Science (New York, N.Y.). 350: aac5137. PMID 26494761 DOI: 10.1126/Science.Aac5137  1
2015 Hurley JH. ESCRTs are everywhere. The Embo Journal. 34: 2398-407. PMID 26311197 DOI: 10.15252/embj.201592484  1
2015 Qi S, Kim do J, Stjepanovic G, Hurley JH. Structure of the Human Atg13-Atg101 HORMA Heterodimer: an Interaction Hub within the ULK1 Complex. Structure (London, England : 1993). 23: 1848-57. PMID 26299944 DOI: 10.1016/J.Str.2015.07.011  1
2015 Yang B, Stjepanovic G, Shen Q, Martin A, Hurley JH. Vps4 disassembles an ESCRT-III filament by global unfolding and processive translocation. Nature Structural & Molecular Biology. 22: 492-8. PMID 25938660 DOI: 10.1038/Nsmb.3015  0.36
2015 Köfinger J, Ragusa MJ, Lee IH, Hummer G, Hurley JH. Solution structure of the Atg1 complex: implications for the architecture of the phagophore assembly site. Structure (London, England : 1993). 23: 809-18. PMID 25817386 DOI: 10.1016/J.Str.2015.02.012  1
2015 Davies CW, Stjepanovic G, Hurley JH. How the Atg1 complex assembles to initiate autophagy. Autophagy. 11: 185-6. PMID 25700739 DOI: 10.4161/15548627.2014.984281  1
2014 Baskaran S, Carlson LA, Stjepanovic G, Young LN, Kim do J, Grob P, Stanley RE, Nogales E, Hurley JH. Architecture and dynamics of the autophagic phosphatidylinositol 3-kinase complex. Elife. 3. PMID 25490155 DOI: 10.7554/Elife.05115  1
2014 Qi S, O'Hayre M, Gutkind JS, Hurley JH. Insights into β2-adrenergic receptor binding from structures of the N-terminal lobe of ARRDC3. Protein Science : a Publication of the Protein Society. 23: 1708-16. PMID 25220262 DOI: 10.1002/Pro.2549  1
2014 Stjepanovic G, Davies CW, Stanley RE, Ragusa MJ, Kim do J, Hurley JH. Assembly and dynamics of the autophagy-initiating Atg1 complex. Proceedings of the National Academy of Sciences of the United States of America. 111: 12793-8. PMID 25139988 DOI: 10.1073/Pnas.1407214111  1
2014 Hurley JH, Schulman BA. Atomistic autophagy: the structures of cellular self-digestion. Cell. 157: 300-11. PMID 24725401 DOI: 10.1016/J.Cell.2014.01.070  1
2014 Ge L, Baskaran S, Schekman R, Hurley JH. The protein-vesicle network of autophagy. Current Opinion in Cell Biology. 29: 18-24. PMID 24681112 DOI: 10.1016/J.Ceb.2014.02.005  1
2014 Ren X, Park SY, Bonifacino JS, Hurley JH. How HIV-1 Nef hijacks the AP-2 clathrin adaptor to downregulate CD4. Elife. 3: e01754. PMID 24473078 DOI: 10.7554/Elife.01754  1
2014 Qi S, O'Hayre M, Gutkind JS, Hurley JH. Structural and biochemical basis for ubiquitin ligase recruitment by arrestin-related domain-containing protein-3 (ARRDC3). The Journal of Biological Chemistry. 289: 4743-52. PMID 24379409 DOI: 10.1074/Jbc.M113.527473  1
2014 Hurley JH, Yang B. Making sense of Vps4. Journal of Molecular Biology. 426: 503-6. PMID 24184199 DOI: 10.1016/j.jmb.2013.10.038  1
2014 Stanley RE, Ragusa MJ, Hurley JH. The beginning of the end: how scaffolds nucleate autophagosome biogenesis. Trends in Cell Biology. 24: 73-81. PMID 23999079 DOI: 10.1016/J.Tcb.2013.07.008  1
2013 Nemecek D, Boura E, Wu W, Cheng N, Plevka P, Qiao J, Mindich L, Heymann JB, Hurley JH, Steven AC. Subunit folds and maturation pathway of a dsRNA virus capsid. Structure (London, England : 1993). 21: 1374-83. PMID 23891288 DOI: 10.1016/J.Str.2013.06.007  1
2013 Gutierrez-Uzquiza A, Colon-Gonzalez F, Leonard TA, Canagarajah BJ, Wang H, Mayer BJ, Hurley JH, Kazanietz MG. Coordinated activation of the Rac-GAP β2-chimaerin by an atypical proline-rich domain and diacylglycerol. Nature Communications. 4: 1849. PMID 23673634 DOI: 10.1038/Ncomms2834  1
2013 Jao CC, Ragusa MJ, Stanley RE, Hurley JH. What the N-terminal domain of Atg13 looks like and what it does: a HORMA fold required for PtdIns 3-kinase recruitment. Autophagy. 9: 1112-4. PMID 23670046 DOI: 10.4161/Auto.24896  1
2013 Jao CC, Ragusa MJ, Stanley RE, Hurley JH. A HORMA domain in Atg13 mediates PI 3-kinase recruitment in autophagy. Proceedings of the National Academy of Sciences of the United States of America. 110: 5486-91. PMID 23509291 DOI: 10.1073/Pnas.1220306110  1
2013 Canagarajah BJ, Ren X, Bonifacino JS, Hurley JH. The clathrin adaptor complexes as a paradigm for membrane-associated allostery. Protein Science : a Publication of the Protein Society. 22: 517-29. PMID 23424177 DOI: 10.1002/Pro.2235  1
2013 Ren X, Farías GG, Canagarajah BJ, Bonifacino JS, Hurley JH. Structural basis for recruitment and activation of the AP-1 clathrin adaptor complex by Arf1. Cell. 152: 755-67. PMID 23415225 DOI: 10.1016/J.Cell.2012.12.042  1
2013 Mardones GA, Burgos PV, Lin Y, Kloer DP, Magadán JG, Hurley JH, Bonifacino JS. Structural basis for the recognition of tyrosine-based sorting signals by the μ3A subunit of the AP-3 adaptor complex. The Journal of Biological Chemistry. 288: 9563-71. PMID 23404500 DOI: 10.1074/Jbc.M113.450775  1
2012 Hurley JH, Hinshaw JE. Dynamin: membrane scission meets physics. Current Biology : Cb. 22: R1047-8. PMID 23257190 DOI: 10.1016/J.Cub.2012.11.008  0.08
2012 Ragusa MJ, Stanley RE, Hurley JH. Architecture of the Atg17 complex as a scaffold for autophagosome biogenesis. Cell. 151: 1501-12. PMID 23219485 DOI: 10.1016/J.Cell.2012.11.028  1
2012 Różycki B, Boura E, Hurley JH, Hummer G. Membrane-elasticity model of Coatless vesicle budding induced by ESCRT complexes. Plos Computational Biology. 8: e1002736. PMID 23093927 DOI: 10.1371/Journal.Pcbi.1002736  1
2012 van Weering JR, Sessions RB, Traer CJ, Kloer DP, Bhatia VK, Stamou D, Carlsson SR, Hurley JH, Cullen PJ. Molecular basis for SNX-BAR-mediated assembly of distinct endosomal sorting tubules. The Embo Journal. 31: 4466-80. PMID 23085988 DOI: 10.1038/Emboj.2012.283  1
2012 Carlson LA, Hurley JH. In vitro reconstitution of the ordered assembly of the endosomal sorting complex required for transport at membrane-bound HIV-1 Gag clusters. Proceedings of the National Academy of Sciences of the United States of America. 109: 16928-33. PMID 23027949 DOI: 10.1073/Pnas.1211759109  1
2012 Baskaran S, Ragusa MJ, Hurley JH. How Atg18 and the WIPIs sense phosphatidylinositol 3-phosphate. Autophagy. 8: 1851-2. PMID 22996041 DOI: 10.4161/Auto.22077  1
2012 Wilson SM, Schmutzler BS, Brittain JM, Dustrude ET, Ripsch MS, Pellman JJ, Yeum TS, Hurley JH, Hingtgen CM, White FA, Khanna R. Inhibition of transmitter release and attenuation of anti-retroviral-associated and tibial nerve injury-related painful peripheral neuropathy by novel synthetic Ca2+ channel peptides. The Journal of Biological Chemistry. 287: 35065-77. PMID 22891239 DOI: 10.1074/Jbc.M112.378695  1
2012 Hurley JH, Bonifacino JS. Nef-arious goings-on at the Golgi. Nature Structural & Molecular Biology. 19: 661-2. PMID 22767237 DOI: 10.1038/Nsmb.2304  1
2012 Hurley JH, Odorizzi G. Get on the exosome bus with ALIX. Nature Cell Biology. 14: 654-5. PMID 22743708 DOI: 10.1038/Ncb2530  1
2012 Boura E, Ivanov V, Carlson LA, Mizuuchi K, Hurley JH. Endosomal sorting complex required for transport (ESCRT) complexes induce phase-separated microdomains in supported lipid bilayers. The Journal of Biological Chemistry. 287: 28144-51. PMID 22718754 DOI: 10.1074/Jbc.M112.378646  1
2012 Baskaran S, Ragusa MJ, Boura E, Hurley JH. Two-site recognition of phosphatidylinositol 3-phosphate by PROPPINs in autophagy. Molecular Cell. 47: 339-48. PMID 22704557 DOI: 10.1016/J.Molcel.2012.05.027  1
2012 Ripsch MS, Ballard CJ, Khanna M, Hurley JH, White FA, Khanna R. A PEPTIDE UNCOUPLING CRMP-2 FROM THE PRESYNAPTIC Ca(2+) CHANNEL COMPLEX DEMONSTRATES EFFICACY IN ANIMAL MODELS OF MIGRAINE AND AIDS THERAPY-INDUCED NEUROPATHY. Translational Neuroscience. 3: 1-8. PMID 22662308 DOI: 10.2478/S13380-012-0002-4  1
2012 Boura E, Różycki B, Chung HS, Herrick DZ, Canagarajah B, Cafiso DS, Eaton WA, Hummer G, Hurley JH. Solution structure of the ESCRT-I and -II supercomplex: implications for membrane budding and scission. Structure (London, England : 1993). 20: 874-86. PMID 22579254 DOI: 10.1016/J.Str.2012.03.008  1
2012 Klionsky DJ, Hurley JH. Self-eating with your fingers. Cell Research. 22: 783-5. PMID 22410794 DOI: 10.1038/Cr.2012.39  1
2012 Boura E, Hurley JH. Structural basis for membrane targeting by the MVB12-associated β-prism domain of the human ESCRT-I MVB12 subunit. Proceedings of the National Academy of Sciences of the United States of America. 109: 1901-6. PMID 22232651 DOI: 10.1073/Pnas.1117597109  1
2012 Lee HH, Nemecek D, Schindler C, Smith WJ, Ghirlando R, Steven AC, Bonifacino JS, Hurley JH. Assembly and architecture of biogenesis of lysosome-related organelles complex-1 (BLOC-1). The Journal of Biological Chemistry. 287: 5882-90. PMID 22203680 DOI: 10.1074/Jbc.M111.325746  1
2011 Leonard TA, Hurley JH. Regulation of protein kinases by lipids. Current Opinion in Structural Biology. 21: 785-91. PMID 22142590 DOI: 10.1016/J.Sbi.2011.07.006  1
2011 Wilson SM, Brittain JM, Piekarz AD, Ballard CJ, Ripsch MS, Cummins TR, Hurley JH, Khanna M, Hammes NM, Samuels BC, White FA, Khanna R. Further insights into the antinociceptive potential of a peptide disrupting the N-type calcium channel-CRMP-2 signaling complex. Channels (Austin, Tex.). 5: 449-56. PMID 21829088 DOI: 10.4161/Chan.5.5.17363  1
2011 Hurley JH. Nipped in the bud: how the AMSH MIT domain helps deubiquitinate lysosome-bound cargo. Structure (London, England : 1993). 19: 1033-5. PMID 21827939 DOI: 10.1016/J.Str.2011.07.002  0.01
2011 Kim SE, Liu F, Im YJ, Stephen AG, Fivash MJ, Waheed AA, Freed EO, Fisher RJ, Hurley JH, Burke TR. Elucidation of New Binding Interactions with the Tumor Susceptibility Gene 101 (Tsg101) Protein Using Modified HIV-1 Gag-p6 Derived Peptide Ligands. Acs Medicinal Chemistry Letters. 2: 337-341. PMID 21643473 DOI: 10.1021/Ml1002579  1
2011 Brittain JM, Duarte DB, Wilson SM, Zhu W, Ballard C, Johnson PL, Liu N, Xiong W, Ripsch MS, Wang Y, Fehrenbacher JC, Fitz SD, Khanna M, Park CK, Schmutzler BS, ... ... Hurley JH, et al. Suppression of inflammatory and neuropathic pain by uncoupling CRMP-2 from the presynaptic Ca²⁺ channel complex. Nature Medicine. 17: 822-9. PMID 21642979 DOI: 10.1038/Nm.2345  1
2011 Boura E, Rózycki B, Herrick DZ, Chung HS, Vecer J, Eaton WA, Cafiso DS, Hummer G, Hurley JH. Solution structure of the ESCRT-I complex by small-angle X-ray scattering, EPR, and FRET spectroscopy. Proceedings of the National Academy of Sciences of the United States of America. 108: 9437-42. PMID 21596998 DOI: 10.1073/Pnas.1101763108  1
2011 Ren X, Hurley JH. Proline-rich regions and motifs in trafficking: from ESCRT interaction to viral exploitation. Traffic (Copenhagen, Denmark). 12: 1282-90. PMID 21518163 DOI: 10.1111/J.1600-0854.2011.01208.X  1
2011 Ren X, Hurley JH. Structural basis for endosomal recruitment of ESCRT-I by ESCRT-0 in yeast. The Embo Journal. 30: 2130-9. PMID 21505419 DOI: 10.1038/Emboj.2011.122  1
2011 Elia N, Sougrat R, Spurlin TA, Hurley JH, Lippincott-Schwartz J. Dynamics of endosomal sorting complex required for transport (ESCRT) machinery during cytokinesis and its role in abscission. Proceedings of the National Academy of Sciences of the United States of America. 108: 4846-51. PMID 21383202 DOI: 10.1073/Pnas.1102714108  1
2011 Hurley JH, Stenmark H. Molecular mechanisms of ubiquitin-dependent membrane traffic. Annual Review of Biophysics. 40: 119-42. PMID 21332354 DOI: 10.1146/Annurev-Biophys-042910-155404  0.01
2011 Leonard TA, Różycki B, Saidi LF, Hummer G, Hurley JH. Crystal structure and allosteric activation of protein kinase C βII. Cell. 144: 55-66. PMID 21215369 DOI: 10.1016/J.Cell.2010.12.013  1
2010 Hurley JH, Boura E, Carlson LA, Różycki B. Membrane budding. Cell. 143: 875-87. PMID 21145455 DOI: 10.1016/j.cell.2010.11.030  1
2010 Im YJ, Kuo L, Ren X, Burgos PV, Zhao XZ, Liu F, Burke TR, Bonifacino JS, Freed EO, Hurley JH. Crystallographic and functional analysis of the ESCRT-I /HIV-1 Gag PTAP interaction. Structure (London, England : 1993). 18: 1536-47. PMID 21070952 DOI: 10.1016/J.Str.2010.08.010  1
2010 Renvoisé B, Parker RL, Yang D, Bakowska JC, Hurley JH, Blackstone C. SPG20 protein spartin is recruited to midbodies by ESCRT-III protein Ist1 and participates in cytokinesis. Molecular Biology of the Cell. 21: 3293-303. PMID 20719964 DOI: 10.1091/Mbc.E09-10-0879  1
2010 Yang D, Hurley JH. Structural role of the Vps4-Vta1 interface in ESCRT-III recycling. Structure (London, England : 1993). 18: 976-84. PMID 20696398 DOI: 10.1016/J.Str.2010.04.014  1
2010 Hurley JH. The ESCRT complexes. Critical Reviews in Biochemistry and Molecular Biology. 45: 463-87. PMID 20653365 DOI: 10.3109/10409238.2010.502516  0.01
2010 Hurley JH, Hanson PI. Membrane budding and scission by the ESCRT machinery: it's all in the neck. Nature Reviews. Molecular Cell Biology. 11: 556-66. PMID 20588296 DOI: 10.1038/Nrm2937  1
2010 Wollert T, Hurley JH. Molecular mechanism of multivesicular body biogenesis by ESCRT complexes. Nature. 464: 864-9. PMID 20305637 DOI: 10.1038/Nature08849  1
2010 Burgos PV, Mardones GA, Rojas AL, daSilva LL, Prabhu Y, Hurley JH, Bonifacino JS. Sorting of the Alzheimer's disease amyloid precursor protein mediated by the AP-4 complex. Developmental Cell. 18: 425-36. PMID 20230749 DOI: 10.1016/J.Devcel.2010.01.015  1
2010 Ren X, Hurley JH. VHS domains of ESCRT-0 cooperate in high-avidity binding to polyubiquitinated cargo. The Embo Journal. 29: 1045-54. PMID 20150893 DOI: 10.1038/Emboj.2010.6  1
2010 Kloer DP, Rojas R, Ivan V, Moriyama K, van Vlijmen T, Murthy N, Ghirlando R, van der Sluijs P, Hurley JH, Bonifacino JS. Assembly of the biogenesis of lysosome-related organelles complex-3 (BLOC-3) and its interaction with Rab9. The Journal of Biological Chemistry. 285: 7794-804. PMID 20048159 DOI: 10.1074/Jbc.M109.069088  1
2009 Reider A, Barker SL, Mishra SK, Im YJ, Maldonado-Báez L, Hurley JH, Traub LM, Wendland B. Syp1 is a conserved endocytic adaptor that contains domains involved in cargo selection and membrane tubulation. The Embo Journal. 28: 3103-16. PMID 19713939 DOI: 10.1038/Emboj.2009.248  1
2009 Im YJ, Wollert T, Boura E, Hurley JH. Structure and function of the ESCRT-II-III interface in multivesicular body biogenesis. Developmental Cell. 17: 234-43. PMID 19686684 DOI: 10.1016/J.Devcel.2009.07.008  1
2009 Wollert T, Yang D, Ren X, Lee HH, Im YJ, Hurley JH. The ESCRT machinery at a glance. Journal of Cell Science. 122: 2163-6. PMID 19535731 DOI: 10.1242/Jcs.029884  1
2009 Hurley JH, Ballard CJ, Edenberg HJ. Altering the relative abundance of GABA A receptor subunits changes GABA- and ethanol-responses in Xenopus oocytes. Alcoholism, Clinical and Experimental Research. 33: 1089-96. PMID 19382902 DOI: 10.1111/J.1530-0277.2009.00930.X  1
2009 Hurley JH, Ren X. The circuitry of cargo flux in the ESCRT pathway. The Journal of Cell Biology. 185: 185-7. PMID 19380875 DOI: 10.1083/jcb.200903013  1
2009 Ren X, Kloer DP, Kim YC, Ghirlando R, Saidi LF, Hummer G, Hurley JH. Hybrid structural model of the complete human ESCRT-0 complex. Structure (London, England : 1993). 17: 406-16. PMID 19278655 DOI: 10.1016/J.Str.2009.01.012  1
2009 Wollert T, Wunder C, Lippincott-Schwartz J, Hurley JH. Membrane scission by the ESCRT-III complex. Nature. 458: 172-7. PMID 19234443 DOI: 10.1038/Nature07836  1
2009 Hurley JH, Im YJ, Lee HH, Ren X, Wollert T, Yang D. Piecing together the ESCRTs. Biochemical Society Transactions. 37: 161-6. PMID 19143623 DOI: 10.1042/Bst0370161  1
2008 Yang D, Rismanchi N, Renvoisé B, Lippincott-Schwartz J, Blackstone C, Hurley JH. Structural basis for midbody targeting of spastin by the ESCRT-III protein CHMP1B. Nature Structural & Molecular Biology. 15: 1278-86. PMID 18997780 DOI: 10.1038/Nsmb.1512  1
2008 Lee HH, Elia N, Ghirlando R, Lippincott-Schwartz J, Hurley JH. Midbody targeting of the ESCRT machinery by a noncanonical coiled coil in CEP55. Science (New York, N.Y.). 322: 576-80. PMID 18948538 DOI: 10.1126/Science.1162042  1
2008 Im YJ, Hurley JH. Integrated structural model and membrane targeting mechanism of the human ESCRT-II complex. Developmental Cell. 14: 902-13. PMID 18539118 DOI: 10.1016/J.Devcel.2008.04.004  1
2008 Bonifacino JS, Hurley JH. Retromer. Current Opinion in Cell Biology. 20: 427-36. PMID 18472259 DOI: 10.1016/  1
2008 Canagarajah BJ, Hummer G, Prinz WA, Hurley JH. Dynamics of cholesterol exchange in the oxysterol binding protein family. Journal of Molecular Biology. 378: 737-48. PMID 18377932 DOI: 10.1016/J.Jmb.2008.01.075  1
2008 Hurley JH. ESCRT complexes and the biogenesis of multivesicular bodies. Current Opinion in Cell Biology. 20: 4-11. PMID 18222686 DOI: 10.1016/J.Ceb.2007.12.002  0.01
2008 Hurley JH, Yang D. MIT domainia. Developmental Cell. 14: 6-8. PMID 18194647 DOI: 10.1016/j.devcel.2007.12.013  1
2008 Lindwasser OW, Smith WJ, Chaudhuri R, Yang P, Hurley JH, Bonifacino JS. A diacidic motif in human immunodeficiency virus type 1 Nef is a novel determinant of binding to AP-2. Journal of Virology. 82: 1166-74. PMID 18032517 DOI: 10.1128/Jvi.01874-07  1
2008 Fox AP, Cahill AL, Currie KP, Grabner C, Harkins AB, Herring B, Hurley JH, Xie Z. N- and P/Q-type Ca2+ channels in adrenal chromaffin cells. Acta Physiologica (Oxford, England). 192: 247-61. PMID 18021320 DOI: 10.1111/J.1748-1716.2007.01817.X  1
2008 Effantin G, Hierro A, Rojas AL, Rojas R, Murthy N, Kajava AV, Bonifacino JS, Hurley JH, Steven AC. Functional architecture of the retromer cargo-recognition complex Microscopy and Microanalysis. 14: 1568-1569. DOI: 10.1017/S1431927608086200  1
2007 Fujii K, Hurley JH, Freed EO. Beyond Tsg101: the role of Alix in 'ESCRTing' HIV-1. Nature Reviews. Microbiology. 5: 912-6. PMID 17982468 DOI: 10.1038/Nrmicro1790  0.32
2007 Hierro A, Rojas AL, Rojas R, Murthy N, Effantin G, Kajava AV, Steven AC, Bonifacino JS, Hurley JH. Functional architecture of the retromer cargo-recognition complex. Nature. 449: 1063-7. PMID 17891154 DOI: 10.1017/S1431927608086200  1
2007 Leonard TA, Hurley JH. Two kinase family dramas. Cell. 129: 1037-8. PMID 17574014 DOI: 10.1016/J.Cell.2007.06.001  1
2007 Prag G, Watson H, Kim YC, Beach BM, Ghirlando R, Hummer G, Bonifacino JS, Hurley JH. The Vps27/Hse1 complex is a GAT domain-based scaffold for ubiquitin-dependent sorting. Developmental Cell. 12: 973-86. PMID 17543868 DOI: 10.1016/J.Devcel.2007.04.013  1
2007 Kostelansky MS, Schluter C, Tam YY, Lee S, Ghirlando R, Beach B, Conibear E, Hurley JH. Molecular architecture and functional model of the complete yeast ESCRT-I heterotetramer. Cell. 129: 485-98. PMID 17442384 DOI: 10.1016/J.Cell.2007.03.016  1
2007 Lee S, Joshi A, Nagashima K, Freed EO, Hurley JH. Structural basis for viral late-domain binding to Alix. Nature Structural & Molecular Biology. 14: 194-9. PMID 17277784 DOI: 10.1038/Nsmb1203  1
2007 Chaudhuri R, Lindwasser OW, Smith WJ, Hurley JH, Bonifacino JS. Downregulation of CD4 by human immunodeficiency virus type 1 Nef is dependent on clathrin and involves direct interaction of Nef with the AP2 clathrin adaptor. Journal of Virology. 81: 3877-90. PMID 17267500 DOI: 10.1128/Jvi.02725-06  1
2007 Munshi UM, Kim J, Nagashima K, Hurley JH, Freed EO. An Alix fragment potently inhibits HIV-1 budding: characterization of binding to retroviral YPXL late domains. The Journal of Biological Chemistry. 282: 3847-55. PMID 17158451 DOI: 10.1074/Jbc.M607489200  1
2006 Hurley JH, Lee S, Prag G. Ubiquitin-binding domains. The Biochemical Journal. 399: 361-72. PMID 17034365 DOI: 10.1042/Bj20061138  1
2006 Shi H, Rojas R, Bonifacino JS, Hurley JH. The retromer subunit Vps26 has an arrestin fold and binds Vps35 through its C-terminal domain. Nature Structural & Molecular Biology. 13: 540-8. PMID 16732284 DOI: 10.1038/Nsmb1103  1
2006 Hurley JH, Emr SD. The ESCRT complexes: structure and mechanism of a membrane-trafficking network. Annual Review of Biophysics and Biomolecular Structure. 35: 277-98. PMID 16689637 DOI: 10.1146/Annurev.Biophys.35.040405.102126  1
2006 Wang H, Yang C, Leskow FC, Sun J, Canagarajah B, Hurley JH, Kazanietz MG. Phospholipase Cgamma/diacylglycerol-dependent activation of beta2-chimaerin restricts EGF-induced Rac signaling. The Embo Journal. 25: 2062-74. PMID 16628218 DOI: 10.1038/Sj.Emboj.7601098  1
2006 Hurley JH. Membrane binding domains. Biochimica Et Biophysica Acta. 1761: 805-11. PMID 16616874 DOI: 10.1016/J.Bbalip.2006.02.020  0.01
2006 Kostelansky MS, Sun J, Lee S, Kim J, Ghirlando R, Hierro A, Emr SD, Hurley JH. Structural and functional organization of the ESCRT-I trafficking complex. Cell. 125: 113-26. PMID 16615894 DOI: 10.1016/J.Cell.2006.01.049  1
2006 Raychaudhuri S, Im YJ, Hurley JH, Prinz WA. Nonvesicular sterol movement from plasma membrane to ER requires oxysterol-binding protein-related proteins and phosphoinositides. The Journal of Cell Biology. 173: 107-19. PMID 16585271 DOI: 10.1083/Jcb.200510084  1
2006 Lee S, Tsai YC, Mattera R, Smith WJ, Kostelansky MS, Weissman AM, Bonifacino JS, Hurley JH. Structural basis for ubiquitin recognition and autoubiquitination by Rabex-5. Nature Structural & Molecular Biology. 13: 264-71. PMID 16462746 DOI: 10.1038/Nsmb1064  1
2006 Canagarajah B, Smith WJ, Hurley JH. Structural Mechanisms of Allosteric Regulation by Membrane-binding Domains Protein-Lipid Interactions: From Membrane Domains to Cellular Networks. 423-436. DOI: 10.1002/3527606769.ch17  1
2005 Hierro A, Kim J, Hurley JH. Polycistronic expression and purification of the ESCRT-II endosomal trafficking complex. Methods in Enzymology. 403: 322-32. PMID 16473598 DOI: 10.1016/S0076-6879(05)03027-2  1
2005 Im YJ, Raychaudhuri S, Prinz WA, Hurley JH. Structural mechanism for sterol sensing and transport by OSBP-related proteins. Nature. 437: 154-8. PMID 16136145 DOI: 10.1038/Nature03923  1
2005 Kim J, Sitaraman S, Hierro A, Beach BM, Odorizzi G, Hurley JH. Structural basis for endosomal targeting by the Bro1 domain. Developmental Cell. 8: 937-47. PMID 15935782 DOI: 10.1016/J.Devcel.2005.04.001  1
2005 Miller GJ, Wilson MP, Majerus PW, Hurley JH. Specificity determinants in inositol polyphosphate synthesis: crystal structure of inositol 1,3,4-trisphosphate 5/6-kinase. Molecular Cell. 18: 201-12. PMID 15837423 DOI: 10.1016/J.Molcel.2005.03.016  1
2005 Prag G, Lee S, Mattera R, Arighi CN, Beach BM, Bonifacino JS, Hurley JH. Structural mechanism for ubiquitinated-cargo recognition by the Golgi-localized, gamma-ear-containing, ADP-ribosylation-factor-binding proteins. Proceedings of the National Academy of Sciences of the United States of America. 102: 2334-9. PMID 15701688 DOI: 10.1073/Pnas.0500118102  1
2004 Canagarajah B, Leskow FC, Ho JY, Mischak H, Saidi LF, Kazanietz MG, Hurley JH. Structural mechanism for lipid activation of the Rac-specific GAP, beta2-chimaerin. Cell. 119: 407-18. PMID 15507211 DOI: 10.1016/J.Cell.2004.10.012  1
2004 Fritz TA, Hurley JH, Trinh LB, Shiloach J, Tabak LA. The beginnings of mucin biosynthesis: the crystal structure of UDP-GalNAc:polypeptide alpha-N-acetylgalactosaminyltransferase-T1. Proceedings of the National Academy of Sciences of the United States of America. 101: 15307-12. PMID 15486088 DOI: 10.1073/Pnas.0405657101  1
2004 Miller GJ, Hurley JH. Crystal structure of the catalytic core of inositol 1,4,5-trisphosphate 3-kinase. Molecular Cell. 15: 703-11. PMID 15350215 DOI: 10.1016/J.Molcel.2004.08.005  0.96
2004 Hierro A, Sun J, Rusnak AS, Kim J, Prag G, Emr SD, Hurley JH. Structure of the ESCRT-II endosomal trafficking complex. Nature. 431: 221-5. PMID 15329733 DOI: 10.1038/Nature02914  1
2004 Chi Y, Zhou B, Wang WQ, Chung SK, Kwon YU, Ahn YH, Chang YT, Tsujishita Y, Hurley JH, Zhang ZY. Comparative mechanistic and substrate specificity study of inositol polyphosphate 5-phosphatase Schizosaccharomyces pombe Synaptojanin and SHIP2. The Journal of Biological Chemistry. 279: 44987-95. PMID 15316017 DOI: 10.1074/Jbc.M406416200  1
2004 Hickenbottom SJ, Kimmel AR, Londos C, Hurley JH. Structure of a lipid droplet protein; the PAT family member TIP47. Structure (London, England : 1993). 12: 1199-207. PMID 15242596 DOI: 10.1016/J.Str.2004.04.021  0.01
2003 Miller GJ, Mattera R, Bonifacino JS, Hurley JH. Recognition of accessory protein motifs by the gamma-adaptin ear domain of GGA3. Nature Structural Biology. 10: 599-606. PMID 12858162 DOI: 10.1038/Nsb953  1
2003 Zhang G, Hurley JH. Crystallization of the protein kinase Cdelta C1B domain. Methods in Molecular Biology (Clifton, N.J.). 233: 299-304. PMID 12840517 DOI: 10.1385/1-59259-397-6:299  1
2003 Trievel RC, Flynn EM, Houtz RL, Hurley JH. Mechanism of multiple lysine methylation by the SET domain enzyme Rubisco LSMT. Nature Structural Biology. 10: 545-52. PMID 12819771 DOI: 10.1038/Nsb946  1
2003 Prag G, Misra S, Jones EA, Ghirlando R, Davies BA, Horazdovsky BF, Hurley JH. Mechanism of ubiquitin recognition by the CUE domain of Vps9p. Cell. 113: 609-20. PMID 12787502 DOI: 10.1016/S0092-8674(03)00364-7  1
2003 Corbin JD, Blount MA, Weeks JL, Beasley A, Kuhn KP, Ho YS, Saidi LF, Hurley JH, Kotera J, Francis SH. [3H]sildenafil binding to phosphodiesterase-5 is specific, kinetically heterogeneous, and stimulated by cGMP. Molecular Pharmacology. 63: 1364-72. PMID 12761347 DOI: 10.1124/Mol.63.6.1364  1
2003 Suer S, Misra S, Saidi LF, Hurley JH. Structure of the GAT domain of human GGA1: a syntaxin amino-terminal domain fold in an endosomal trafficking adaptor. Proceedings of the National Academy of Sciences of the United States of America. 100: 4451-6. PMID 12668765 DOI: 10.1073/Pnas.0831133100  1
2003 Shih SC, Prag G, Francis SA, Sutanto MA, Hurley JH, Hicke L. A ubiquitin-binding motif required for intramolecular monoubiquitylation, the CUE domain. The Embo Journal. 22: 1273-81. PMID 12628920 DOI: 10.1093/Emboj/Cdg140  1
2003 Hurley JH. Membrane proteins: adapting to life at the interface. Chemistry & Biology. 10: 2-3. PMID 12573692 DOI: 10.1016/S1074-5521(03)00006-1  0.01
2002 Hurley JH, Wendland B. Endocytosis: driving membranes around the bend. Cell. 111: 143-6. PMID 12408856 DOI: 10.1016/S0092-8674(02)01044-9  1
2002 Trievel RC, Beach BM, Dirk LM, Houtz RL, Hurley JH. Structure and catalytic mechanism of a SET domain protein methyltransferase. Cell. 111: 91-103. PMID 12372303 DOI: 10.1016/S0092-8674(02)01000-0  1
2002 Kato Y, Misra S, Puertollano R, Hurley JH, Bonifacino JS. Phosphoregulation of sorting signal-VHS domain interactions by a direct electrostatic mechanism Nature Structural Biology. 9: 532-536. PMID 12032548 DOI: 10.1038/Nsb807  1
2002 Aasland R, Abrams C, Ampe C, Ball LJ, Bedford MT, Cesareni G, Gimona M, Hurley JH, Jarchau T, Lehto VP, Lemmon MA, Linding R, Mayer BJ, Nagai M, Sudol M, et al. Normalization of nomenclature for peptide motifs as ligands of modular protein domains. Febs Letters. 513: 141-4. PMID 11911894 DOI: 10.1016/S0014-5793(01)03295-1  1
2002 Misra S, Puertollano R, Kato Y, Bonifacino JS, Hurley JH. Structural basis for acidic-clusterdileucine sorting-signal recognition by VHS domains Nature. 415: 933-937. PMID 11859375 DOI: 10.1038/415933A  1
2002 Hurley JH, Anderson DE, Beach B, Canagarajah B, Ho YS, Jones E, Miller G, Misra S, Pearson M, Saidi L, Suer S, Trievel R, Tsujishita Y. Structural genomics and signaling domains. Trends in Biochemical Sciences. 27: 48-53. PMID 11796224 DOI: 10.1016/S0968-0004(01)02022-9  1
2001 Misra S, Miller GJ, Hurley JH. Recognizing phosphatidylinositol 3-phosphate. Cell. 107: 559-62. PMID 11733055 DOI: 10.1016/S0092-8674(01)00594-3  1
2001 Tsujishita Y, Guo S, Stolz LE, York JD, Hurley JH. Specificity determinants in phosphoinositide dephosphorylation: crystal structure of an archetypal inositol polyphosphate 5-phosphatase. Cell. 105: 379-89. PMID 11348594 DOI: 10.1016/S0092-8674(01)00326-9  1
2001 Hurley JH, Meyer T. Subcellular targeting by membrane lipids. Current Opinion in Cell Biology. 13: 146-52. PMID 11248547 DOI: 10.1016/S0955-0674(00)00191-5  0.01
2000 Hurley JH, Tsujishita Y, Pearson MA. Floundering about at cell membranes: A structural view of phospholipid signaling Current Opinion in Structural Biology. 10: 737-743. PMID 11114512 DOI: 10.1016/S0959-440X(00)00144-5  1
2000 Misra S, Beach BM, Hurley JH. Structure of the VHS domain of human Tom1 (target of myb 1): Insights into interactions with proteins and membranes Biochemistry. 39: 11282-11290. PMID 10985773 DOI: 10.1021/Bi0013546  1
2000 Hurley JH, Misra S. Signaling and subcellular targeting by membrane-binding domains. Annual Review of Biophysics and Biomolecular Structure. 29: 49-79. PMID 10940243 DOI: 10.1146/Annurev.Biophys.29.1.49  1
2000 Hurley JH, Cahill AL, Currie KP, Fox AP. The role of dynamic palmitoylation in Ca2+ channel inactivation. Proceedings of the National Academy of Sciences of the United States of America. 97: 9293-8. PMID 10900273 DOI: 10.1073/Pnas.160589697  1
2000 Tsujishita Y, Hurley JH. Structure and lipid transport mechanism of a StAR-related domain. Nature Structural Biology. 7: 408-14. PMID 10802740 DOI: 10.1038/75192  1
2000 Kunz J, Wilson MP, Kisseleva M, Hurley JH, Majerus PW, Anderson RA. The activation loop of phosphatidylinositol phosphate kinases determines signaling specificity. Molecular Cell. 5: 1-11. PMID 10678164 DOI: 10.1016/S1097-2765(00)80398-6  1
1999 Burden LM, Rao VD, Murray D, Ghirlando R, Doughman SD, Anderson RA, Hurley JH. The flattened face of type IIβ phosphatidylinositol phosphate kinase binds acidic phospholipid membranes Biochemistry. 38: 15141-15149. PMID 10563796 DOI: 10.1021/Bi991571A  1
1999 Misra S, Hurley JH. Crystal structure of a phosphatidylinositol 3-phosphate-specific membrane-targeting motif, the FYVE domain of Vps27p. Cell. 97: 657-66. PMID 10367894 DOI: 10.1016/S0092-8674(00)80776-X  1
1999 Hurley JH, Bloem LJ, Pavalko F, Liu J, Tian M, Simon JR, Yu L. Structure-function studies of the eighth hydrophobic domain of a serotonin receptor. Journal of Neurochemistry. 72: 413-21. PMID 9886095 DOI: 10.1046/J.1471-4159.1999.0720413.X  1
1998 Rao VD, Misra S, Boronenkov IV, Anderson RA, Hurley JH. Structure of type IIbeta phosphatidylinositol phosphate kinase: a protein kinase fold flattened for interfacial phosphorylation. Cell. 94: 829-39. PMID 9753329 DOI: 10.1016/S0092-8674(00)81741-9  1
1998 Tucker CL, Hurley JH, Miller TR, Hurley JB. Two amino acid substitutions convert a guanylyl cyclase, RetGC-1, into an adenylyl cyclase Proceedings of the National Academy of Sciences of the United States of America. 95: 5993-5997. PMID 9600905 DOI: 10.1073/Pnas.95.11.5993  1
1997 Liu Y, Ruoho AE, Rao VD, Hurley JH. Catalytic mechanism of the adenylyl and guanylyl cyclases: modeling and mutational analysis. Proceedings of the National Academy of Sciences of the United States of America. 94: 13414-9. PMID 9391039 DOI: 10.1073/Pnas.94.25.13414  1
1997 Hurley JH, Grobler JA. Protein kinase C and phospholipase C: bilayer interactions and regulation. Current Opinion in Structural Biology. 7: 557-65. PMID 9266179 DOI: 10.1016/S0959-440X(97)80122-4  0.12
1997 Hurley JH, Newton AC, Parker PJ, Blumberg PM, Nishizuka Y. Taxonomy and function of C1 protein kinase C homology domains. Protein Science : a Publication of the Protein Society. 6: 477-80. PMID 9041654 DOI: 10.1002/Pro.5560060228  1
1997 Chen R, Greer AF, Dean AM, Hurley JH. Engineering secondary structure to invert coenzyme specificity in isopropylmalate dehydrogenase Techniques in Protein Chemistry. 8: 809-816. DOI: 10.1016/S1080-8914(97)80078-6  1
1996 Endrizzi J, Zhang G, Xiong WC, Hurley JH, Remington SJ, Colman RF. Crystallization and preliminary diffraction analysis of porcine heart mitochondrial NADP(+)-dependent isocitrate dehydrogenase. Acta Crystallographica. Section D, Biological Crystallography. 52: 1024-6. PMID 15299615 DOI: 10.1107/S0907444996006154  1
1996 Chen R, Grobler JA, Hurley JH, Dean AM. Second-site suppression of regulatory phosphorylation in Escherichia coli isocitrate dehydrogenase. Protein Science : a Publication of the Protein Society. 5: 287-95. PMID 8745407 DOI: 10.1002/Pro.5560050213  1
1996 Hurley JH, Chen R, Dean AM. Determinants of cofactor specificity in isocitrate dehydrogenase: structure of an engineered NADP+ --> NAD+ specificity-reversal mutant. Biochemistry. 35: 5670-8. PMID 8639526 DOI: 10.1021/Bi953001Q  1
1995 Zhang G, Kazanietz MG, Blumberg PM, Hurley JH. Crystal structure of the cys2 activator-binding domain of protein kinase C delta in complex with phorbol ester. Cell. 81: 917-24. PMID 7781068 DOI: 10.1016/0092-8674(95)90011-X  1
1994 Hurley JH, Dean AM. Structure of 3-isopropylmalate dehydrogenase in complex with NAD+: ligand-induced loop closing and mechanism for cofactor specificity. Structure (London, England : 1993). 2: 1007-16. PMID 7881901 DOI: 10.1016/S0969-2126(94)00104-9  1
1993 Hurley JH, Faber HR, Worthylake D, Meadow ND, Roseman S, Pettigrew DW, Remington SJ. Structure of the regulatory complex of Escherichia coli IIIGlc with glycerol kinase. Science (New York, N.Y.). 259: 673-7. PMID 8430315  1
1993 Anderson DE, Hurley JH, Nicholson H, Baase WA, Matthews BW. Hydrophobic core repacking and aromatic-aromatic interaction in the thermostable mutant of T4 lysozyme Ser 117 → Phe Protein Science. 2: 1285-1290. PMID 8401213 DOI: 10.1002/Pro.5560020811  1
1992 Hurley JH, Baase WA, Matthews BW. Design and structural analysis of alternative hydrophobic core packing arrangements in bacteriophage T4 lysozyme. Journal of Molecular Biology. 224: 1143-59. PMID 1569571 DOI: 10.1016/0022-2836(92)90475-Y  1
1992 Finer-Moore JS, Kossiakoff AA, Hurley JH, Earnest T, Stroud RM. Solvent structure in crystals of trypsin determined by X-ray and neutron diffraction. Proteins. 12: 203-22. PMID 1557349 DOI: 10.1002/Prot.340120302  1
1992 Hurley JH, Mason DA, Matthews BW. Flexible-geometry conformational energy maps for the amino acid residue preceding a proline. Biopolymers. 32: 1443-6. PMID 1457725 DOI: 10.1002/Bip.360321104  1
1991 Hurley JH, Dean AM, Koshland DE, Stroud RM. Catalytic mechanism of NADP(+)-dependent isocitrate dehydrogenase: implications from the structures of magnesium-isocitrate and NADP+ complexes. Biochemistry. 30: 8671-8. PMID 1888729 DOI: 10.1021/Bi00099A026  1
1990 Hurley JH, Dean AM, Thorsness PE, Koshland DE, Stroud RM. Regulation of isocitrate dehydrogenase by phosphorylation involves no long-range conformational change in the free enzyme. The Journal of Biological Chemistry. 265: 3599-602. PMID 2406256 DOI: 10.2210/Pdb4Icd/Pdb  1
1990 Hurley JH, Dean AM, Sohl JL, Koshland DE, Stroud RM. Regulation of an enzyme by phosphorylation at the active site. Science (New York, N.Y.). 249: 1012-6. PMID 2204109 DOI: 10.1126/Science.2204109  1
1989 Hurley JH, Thorsness PE, Ramalingam V, Helmers NH, Koshland DE, Stroud RM. Structure of a bacterial enzyme regulated by phosphorylation, isocitrate dehydrogenase Proceedings of the National Academy of Sciences of the United States of America. 86: 8635-8639. PMID 2682654 DOI: 10.1073/Pnas.86.22.8635  1
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