Stephen J. Elledge - Publications

Affiliations: 
1989-2003 Baylor College of Medicine, Houston, TX 
 2003- Genetics Harvard Medical School, Boston, MA, United States 
Area:
response to DNA damage and regulation of the cell cycle
Website:
http://genetics.med.harvard.edu/faculty/elledge

250 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any innacuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2019 Haigis KM, Cichowski K, Elledge SJ. Tissue-specificity in cancer: The rule, not the exception. Science (New York, N.Y.). 363: 1150-1151. PMID 30872507 DOI: 10.1126/science.aaw3472  0.48
2019 Mengwasser KE, Adeyemi RO, Leng Y, Choi MY, Clairmont C, D'Andrea AD, Elledge SJ. Genetic Screens Reveal FEN1 and APEX2 as BRCA2 Synthetic Lethal Targets. Molecular Cell. PMID 30686591 DOI: 10.1016/j.molcel.2018.12.008  0.68
2018 Rousseaux MWC, Vázquez-Vélez GE, Al-Ramahi I, Jeong HH, Bajic A, Revelli JP, Ye H, Phan ET, Deger JM, Perez AM, Kim JY, Lavery LA, Xu Q, Li MZ, Kang H, ... ... Elledge SJ, et al. A druggable genome screen identifies modifiers of α-synuclein levels via a tiered cross-species validation approach. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. PMID 30249792 DOI: 10.1523/JNEUROSCI.0254-18.2018  1
2018 Hernandez N, Melki I, Jing H, Habib T, Huang SSY, Danielson J, Kula T, Drutman S, Belkaya S, Rattina V, Lorenzo-Diaz L, Boulai A, Rose Y, Kitabayashi N, Rodero MP, ... ... Elledge SJ, et al. Life-threatening influenza pneumonitis in a child with inherited IRF9 deficiency. The Journal of Experimental Medicine. PMID 30143481 DOI: 10.1084/jem.20180628  0.6
2018 Liao S, Maertens O, Cichowski K, Elledge SJ. Genetic modifiers of the BRD4-NUT dependency of NUT midline carcinoma uncovers a synergism between BETis and CDK4/6is. Genes & Development. PMID 30135075 DOI: 10.1101/gad.315648.118  0.68
2018 Koren I, Timms RT, Kula T, Xu Q, Li MZ, Elledge SJ. The Eukaryotic Proteome Is Shaped by E3 Ubiquitin Ligases Targeting C-Terminal Degrons. Cell. PMID 29779948 DOI: 10.1016/j.cell.2018.04.028  1
2018 Lin HC, Yeh CW, Chen YF, Lee TT, Hsieh PY, Rusnac DV, Lin SY, Elledge SJ, Zheng N, Yen HS. C-Terminal End-Directed Protein Elimination by CRL2 Ubiquitin Ligases. Molecular Cell. 70: 602-613.e3. PMID 29775578 DOI: 10.1016/j.molcel.2018.04.006  0.56
2018 Sack LM, Davoli T, Li MZ, Li Y, Xu Q, Naxerova K, Wooten EC, Bernardi RJ, Martin TD, Chen T, Leng Y, Liang AC, Scorsone KA, Westbrook TF, Wong KK, ... Elledge SJ, et al. Profound Tissue Specificity in Proliferation Control Underlies Cancer Drivers and Aneuploidy Patterns. Cell. PMID 29576454 DOI: 10.1016/j.cell.2018.02.037  1
2018 Brumbaugh J, Di Stefano B, Wang X, Borkent M, Forouzmand E, Clowers KJ, Ji F, Schwarz BA, Kalocsay M, Elledge SJ, Chen Y, Sadreyev RI, Gygi SP, Hu G, Shi Y, et al. Nudt21 Controls Cell Fate by Connecting Alternative Polyadenylation to Chromatin Signaling. Cell. 172: 629-631. PMID 29373832 DOI: 10.1016/j.cell.2017.12.035  0.92
2017 Mazzucco AE, Smogorzewska A, Kang C, Luo J, Schlabach MR, Xu Q, Patel R, Elledge SJ. Corrigendum: Genetic interrogation of replicative senescence uncovers a dual role for USP28 in coordinating the p53 and GATA4 branches of the senescence program. Genes & Development. 31: 2310. PMID 29284711 DOI: 10.1101/gad.309864.117  1
2017 Brumbaugh J, Di Stefano B, Wang X, Borkent M, Forouzmand E, Clowers KJ, Ji F, Schwarz BA, Kalocsay M, Elledge SJ, Chen Y, Sadreyev RI, Gygi SP, Hu G, Shi Y, et al. Nudt21 Controls Cell Fate by Connecting Alternative Polyadenylation to Chromatin Signaling. Cell. PMID 29249356 DOI: 10.1016/j.cell.2017.11.023  0.92
2017 Mazzucco AE, Smogorzewska A, Kang C, Luo J, Schlabach MR, Xu Q, Patel R, Elledge SJ. Genetic interrogation of replicative senescence uncovers a dual role for USP28 in coordinating the p53 and GATA4 branches of the senescence program. Genes & Development. 31: 1933-1938. PMID 29089421 DOI: 10.1101/gad.304857.117  1
2017 Martin TD, Cook DR, Choi MY, Li MZ, Haigis KM, Elledge SJ. A Role for Mitochondrial Translation in Promotion of Viability in K-Ras Mutant Cells. Cell Reports. 20: 427-438. PMID 28700943 DOI: 10.1016/j.celrep.2017.06.061  1
2017 Shah AA, Xu G, Rosen A, Hummers LK, Wigley FM, Elledge SJ, Casciola-Rosen L. Reply to "Understanding the role of antibodies as markers of cancer coexistence in systemic sclerosis" by Bernal-Bello et al. Arthritis & Rheumatology (Hoboken, N.J.). PMID 28454209 DOI: 10.1002/art.40132  0.52
2017 Shah AA, Xu G, Rosen A, Hummers LK, Wigley FM, Elledge SJ, Casciola-Rosen L. Anti-RNPC3 Antibodies as a Marker of Cancer-Associated Scleroderma. Arthritis & Rheumatology (Hoboken, N.J.). PMID 28217959 DOI: 10.1002/art.40065  0.52
2017 Liao S, Davoli T, Leng Y, Li MZ, Xu Q, Elledge SJ. A genetic interaction analysis identifies cancer drivers that modify EGFR dependency. Genes & Development. PMID 28167502 DOI: 10.1101/gad.291948.116  1
2017 Davoli T, Uno H, Wooten EC, Elledge SJ. Tumor aneuploidy correlates with markers of immune evasion and with reduced response to immunotherapy. Science (New York, N.Y.). 355. PMID 28104840 DOI: 10.1126/science.aaf8399  0.72
2016 Davoli T, Mengwasser KE, Duan J, Chen T, Christensen C, Wooten EC, Anselmo AN, Li MZ, Wong KK, Kahle KT, Elledge SJ. Functional genomics reveals that tumors with activating phosphoinositide 3-kinase mutations are dependent on accelerated protein turnover. Genes & Development. 30: 2684-2695. PMID 28087713 DOI: 10.1101/gad.290122.116  1
2016 Xu GJ, Shah AA, Li MZ, Xu Q, Rosen A, Casciola-Rosen L, Elledge SJ. Systematic autoantigen analysis identifies a distinct subtype of scleroderma with coincident cancer. Proceedings of the National Academy of Sciences of the United States of America. PMID 27821747 DOI: 10.1073/pnas.1615990113  1
2016 Zhang J, Gao G, Begum G, Wang J, Khanna AR, Shmukler BE, Daubner GM, de Los Heros P, Davies P, Varghese J, Bhuiyan MI, Duan J, Zhang J, Duran D, Alper SL, ... ... Elledge SJ, et al. Functional kinomics establishes a critical node of volume-sensitive cation-Cl(-) cotransporter regulation in the mammalian brain. Scientific Reports. 6: 35986. PMID 27782176 DOI: 10.1038/srep35986  0.56
2016 Sack LM, Davoli T, Xu Q, Li M, Elledge SJ. Sources of Error in Mammalian Genetic Screens. G3 (Bethesda, Md.). PMID 27402361 DOI: 10.1534/g3.116.030973  0.92
2016 Zhou C, Elia AE, Naylor ML, Dephoure N, Ballif BA, Goel G, Xu Q, Ng A, Chou DM, Xavier RJ, Gygi SP, Elledge SJ. Profiling DNA damage-induced phosphorylation in budding yeast reveals diverse signaling networks. Proceedings of the National Academy of Sciences of the United States of America. PMID 27298372 DOI: 10.1073/pnas.1602827113  1
2016 Willis NA, Zhou C, Elia AE, Murray JM, Carr AM, Elledge SJ, Rhind N. Identification of S-phase DNA damage-response targets in fission yeast reveals conservation of damage-response networks. Proceedings of the National Academy of Sciences of the United States of America. PMID 27298342 DOI: 10.1073/pnas.1525620113  1
2016 Kang C, Elledge SJ. How autophagy both activates and inhibits cellular senescence. Autophagy. 12: 898-9. PMID 27129029 DOI: 10.1080/15548627.2015.1121361  0.68
2016 Borkent M, Bennett BD, Lackford B, Bar-Nur O, Brumbaugh J, Wang L, Du Y, Fargo DC, Apostolou E, Cheloufi S, Maherali N, Elledge SJ, Hu G, Hochedlinger K. A Serial shRNA Screen for Roadblocks to Reprogramming Identifies the Protein Modifier SUMO2. Stem Cell Reports. PMID 26947976 DOI: 10.1016/j.stemcr.2016.02.004  1
2016 Wang Y, Xu Q, Sack L, Kang C, Elledge SJ. A gain-of-function senescence bypass screen identifies the homeobox transcription factor DLX2 as a regulator of ATM-p53 signaling. Genes & Development. 30: 293-306. PMID 26833729 DOI: 10.1101/gad.271445.115  1
2015 Tripathi S, Pohl MO, Zhou Y, Rodriguez-Frandsen A, Wang G, Stein DA, Moulton HM, DeJesus P, Che J, Mulder LC, Yángüez E, Andenmatten D, Pache L, Manicassamy B, Albrecht RA, ... ... Elledge S, et al. Meta- and Orthogonal Integration of Influenza "OMICs" Data Defines a Role for UBR4 in Virus Budding. Cell Host & Microbe. 18: 723-735. PMID 26651948 DOI: 10.1016/j.chom.2015.11.002  1
2015 Elia AE, Wang DC, Willis NA, Boardman AP, Hajdu I, Adeyemi RO, Lowry E, Gygi SP, Scully R, Elledge SJ. RFWD3-Dependent Ubiquitination of RPA Regulates Repair at Stalled Replication Forks. Molecular Cell. 60: 280-93. PMID 26474068 DOI: 10.1016/j.molcel.2015.09.011  1
2015 Kang C, Xu Q, Martin TD, Li MZ, Demaria M, Aron L, Lu T, Yankner BA, Campisi J, Elledge SJ. The DNA damage response induces inflammation and senescence by inhibiting autophagy of GATA4. Science (New York, N.Y.). 349: aaa5612. PMID 26404840 DOI: 10.1126/science.aaa5612  1
2015 Huang H, Santoso N, Power D, Simpson S, Dieringer M, Miao H, Gurova K, Giam CZ, Elledge S, Zhu J. FACT Proteins, SUPT16H and SSRP1, are Transcriptional Suppressors of HIV-1 and HTLV-1 that Facilitate Viral Latency. The Journal of Biological Chemistry. PMID 26378236 DOI: 10.1074/jbc.M115.652339  1
2015 Elledge SJ. Accidents and Damage Control. Cell. 162: 1196-200. PMID 26359977 DOI: 10.1016/j.cell.2015.08.042  1
2015 Elledge SJ. The DNA Damage Response--Self-awareness for DNA: The 2015 Albert Lasker Basic Medical Research Award. Jama. 314: 1111-2. PMID 26348099 DOI: 10.1001/jama.2015.10387  1
2015 Elia AE, Boardman AP, Wang DC, Huttlin EL, Everley RA, Dephoure N, Zhou C, Koren I, Gygi SP, Elledge SJ. Quantitative Proteomic Atlas of Ubiquitination and Acetylation in the DNA Damage Response. Molecular Cell. PMID 26051181 DOI: 10.1016/j.molcel.2015.05.006  1
2015 Xu GJ, Kula T, Xu Q, Li MZ, Vernon SD, Ndung'u T, Ruxrungtham K, Sanchez J, Brander C, Chung RT, O'Connor KC, Walker B, Larman HB, Elledge SJ. Viral immunology. Comprehensive serological profiling of human populations using a synthetic human virome. Science (New York, N.Y.). 348: aaa0698. PMID 26045439 DOI: 10.1126/science.aaa0698  1
2015 Izhar L, Adamson B, Ciccia A, Lewis J, Pontano-Vaites L, Leng Y, Liang AC, Westbrook TF, Harper JW, Elledge SJ. A Systematic Analysis of Factors Localized to Damaged Chromatin Reveals PARP-Dependent Recruitment of Transcription Factors. Cell Reports. 11: 1486-500. PMID 26004182 DOI: 10.1016/j.celrep.2015.04.053  1
2015 Gao J, Kim HM, Elia AE, Elledge SJ, Colaiácovo MP. NatB domain-containing CRA-1 antagonizes hydrolase ACER-1 linking acetyl-CoA metabolism to the initiation of recombination during C. elegans meiosis. Plos Genetics. 11: e1005029. PMID 25768301 DOI: 10.1371/journal.pgen.1005029  1
2015 Ceccaldi R, Liu JC, Amunugama R, Hajdu I, Primack B, Petalcorin MI, O'Connor KW, Konstantinopoulos PA, Elledge SJ, Boulton SJ, Yusufzai T, D'Andrea AD. Homologous-recombination-deficient tumours are dependent on Polθ-mediated repair. Nature. 518: 258-62. PMID 25642963 DOI: 10.1038/nature14184  0.36
2015 Naxerova K, Elledge SJ. Taking the brakes off telomerase Elife. 4: 1-3. DOI: 10.7554/eLife.09519  1
2015 Ceccaldi R, Liu JC, Amunugama R, Hajdu I, Primack B, Petalcorin MIR, O'Connor KW, Konstantinopoulos PA, Elledge SJ, Boulton SJ, Yusufzai T, D'Andrea AD. Homologous-recombination-deficient tumours are dependent on Polθ -mediated repair Nature. 518: 258-262. DOI: 10.1038/nature14184  1
2014 Ciccia A, Huang JW, Izhar L, Sowa ME, Harper JW, Elledge SJ. Treacher Collins syndrome TCOF1 protein cooperates with NBS1 in the DNA damage response. Proceedings of the National Academy of Sciences of the United States of America. 111: 18631-6. PMID 25512513 DOI: 10.1073/pnas.1422488112  1
2014 Wang R, Persky NS, Yoo B, Ouerfelli O, Smogorzewska A, Elledge SJ, Pavletich NP. DNA repair. Mechanism of DNA interstrand cross-link processing by repair nuclease FAN1. Science (New York, N.Y.). 346: 1127-30. PMID 25430771 DOI: 10.1126/science.1258973  0.68
2014 Zhu J, Davoli T, Perriera JM, Chin CR, Gaiha GD, John SP, Sigiollot FD, Gao G, Xu Q, Qu H, Pertel T, Sims JS, Smith JA, Baker RE, Maranda L, ... ... Elledge SJ, et al. Comprehensive identification of host modulators of HIV-1 replication using multiple orthologous RNAi reagents. Cell Reports. 9: 752-66. PMID 25373910 DOI: 10.1016/j.celrep.2014.09.031  1
2014 Seo M, Lee S, Kim JH, Lee WH, Hu G, Elledge SJ, Suk K. RNAi-based functional selection identifies novel cell migration determinants dependent on PI3K and AKT pathways. Nature Communications. 5: 5217. PMID 25347953 DOI: 10.1038/ncomms6217  0.64
2014 Tan X, Elledge SJ. When noise makes music: HIV reactivation with transcriptional noise enhancers. Genome Medicine. 6: 55. PMID 25276233 DOI: 10.1186/s13073-014-0055-9  1
2014 Finton KA, Friend D, Jaffe J, Gewe M, Holmes MA, Larman HB, Stuart A, Larimore K, Greenberg PD, Elledge SJ, Stamatatos L, Strong RK. Ontogeny of recognition specificity and functionality for the broadly neutralizing anti-HIV antibody 4E10. Plos Pathogens. 10: e1004403. PMID 25254371 DOI: 10.1371/journal.ppat.1004403  1
2014 Li J, Zhu S, Kozono D, Ng K, Futalan D, Shen Y, Akers JC, Steed T, Kushwaha D, Schlabach M, Carter BS, Kwon CH, Furnari F, Cavenee W, Elledge S, et al. Genome-wide shRNA screen revealed integrated mitogenic signaling between dopamine receptor D2 (DRD2) and epidermal growth factor receptor (EGFR) in glioblastoma. Oncotarget. 5: 882-93. PMID 24658464  1
2014 Yoon JC, Ling AJ, Isik M, Lee DY, Steinbaugh MJ, Sack LM, Boduch AN, Blackwell TK, Sinclair DA, Elledge SJ. GLTSCR2/PICT1 links mitochondrial stress and Myc signaling. Proceedings of the National Academy of Sciences of the United States of America. 111: 3781-6. PMID 24556985 DOI: 10.1073/pnas.1400705111  1
2014 Olive AJ, Haff MG, Emanuele MJ, Sack LM, Barker JR, Elledge SJ, Starnbach MN. Chlamydia trachomatis-induced alterations in the host cell proteome are required for intracellular growth. Cell Host & Microbe. 15: 113-24. PMID 24439903 DOI: 10.1016/j.chom.2013.12.009  1
2014 Larman HB, Liang AC, Elledge SJ, Zhu J. Discovery of protein interactions using parallel analysis of translated ORFs (PLATO) Nature Protocols. 9: 90-103. PMID 24336473 DOI: 10.1038/nprot.2013.167  1
2014 Wang R, Persky NS, Yoo B, Ouerfelli O, Smogorzewska A, Elledge SJ, Pavletich NP. Mechanism of DNA interstrand cross-link processing by repair nuclease FAN1 Science. 346: 1127-1130. DOI: 10.1126/science.1258973  1
2014 Seo M, Lee S, Kim JH, Lee WH, Hu G, Elledge SJ, Suk K. RNAi-based functional selection identifies novel cell migration determinants dependent on PI3K and AKT pathways Nature Communications. 5. DOI: 10.1038/ncomms6217  1
2013 Lin TY, Chin CR, Everitt AR, Clare S, Perreira JM, Savidis G, Aker AM, John SP, Sarlah D, Carreira EM, Elledge SJ, Kellam P, Brass AL. Amphotericin B increases influenza A virus infection by preventing IFITM3-mediated restriction. Cell Reports. 5: 895-908. PMID 24268777 DOI: 10.1016/j.celrep.2013.10.033  1
2013 Davoli T, Xu AW, Mengwasser KE, Sack LM, Yoon JC, Park PJ, Elledge SJ. Cumulative haploinsufficiency and triplosensitivity drive aneuploidy patterns and shape the cancer genome. Cell. 155: 948-62. PMID 24183448 DOI: 10.1016/j.cell.2013.10.011  1
2013 Finton KAK, Larimore K, Larman HB, Friend D, Correnti C, Rupert PB, Elledge SJ, Greenberg PD, Strong RK. Autoreactivity and Exceptional CDR Plasticity (but Not Unusual Polyspecificity) Hinder Elicitation of the Anti-HIV Antibody 4E10 Plos Pathogens. 9. PMID 24086134 DOI: 10.1371/journal.ppat.1003639  1
2013 Altindis E, Alpar MA, Aksay E, Beckwith J, Bökel C, Curl RF, Darnell RB, Elledge SJ, Erman B, Frahm J, Goff SP, Greengard P, Hoffmann R, Ilhan B, Kaslin J, et al. Turkey must end violent response to protests. Science (New York, N.Y.). 341: 236. PMID 23869001 DOI: 10.1126/science.341.6143.236-a  1
2013 Tajonar A, Maehr R, Hu G, Sneddon JB, Rivera-Feliciano J, Cohen DE, Elledge SJ, Melton DA. Brief report: VGLL4 is a novel regulator of survival in human embryonic stem cells. Stem Cells (Dayton, Ohio). 31: 2833-41. PMID 23765749 DOI: 10.1002/stem.1445  1
2013 Pavlova NN, Pallasch C, Elia AE, Braun CJ, Westbrook TF, Hemann M, Elledge SJ. A role for PVRL4-driven cell-cell interactions in tumorigenesis. Elife. 2: e00358. PMID 23682311 DOI: 10.7554/eLife.00358  1
2013 John SP, Chin CR, Perreira JM, Feeley EM, Aker AM, Savidis G, Smith SE, Elia AE, Everitt AR, Vora M, Pertel T, Elledge SJ, Kellam P, Brass AL. The CD225 domain of IFITM3 is required for both IFITM protein association and inhibition of influenza A virus and dengue virus replication. Journal of Virology. 87: 7837-52. PMID 23658454 DOI: 10.1128/JVI.00481-13  1
2013 Larman HB, Salajegheh M, Nazareno R, Lam T, Sauld J, Steen H, Kong SW, Pinkus JL, Amato AA, Elledge SJ, Greenberg SA. Cytosolic 5'-nucleotidase 1A autoimmunity in sporadic inclusion body myositis. Annals of Neurology. 73: 408-18. PMID 23596012 DOI: 10.1002/ana.23840  1
2013 Zhu J, Larman HB, Gao G, Somwar R, Zhang Z, Laserson U, Ciccia A, Pavlova N, Church G, Zhang W, Kesari S, Elledge SJ. Protein interaction discovery using parallel analysis of translated ORFs (PLATO). Nature Biotechnology. 31: 331-4. PMID 23503679 DOI: 10.1038/nbt.2539  1
2013 Larman HB, Laserson U, Querol L, Verhaeghen K, Solimini NL, Xu GJ, Klarenbeek PL, Church GM, Hafler DA, Plenge RM, Nigrovic PA, De Jager PL, Weets I, Martens GA, O'Connor KC, ... Elledge SJ, et al. PhIP-Seq characterization of autoantibodies from patients with multiple sclerosis, type 1 diabetes and rheumatoid arthritis. Journal of Autoimmunity. 43: 1-9. PMID 23497938 DOI: 10.1016/j.jaut.2013.01.013  0.96
2013 Liu Q, Xu C, Kirubakaran S, Zhang X, Hur W, Liu Y, Kwiatkowski NP, Wang J, Westover KD, Gao P, Ercan D, Niepel M, Thoreen CC, Kang SA, Patricelli MP, ... ... Elledge SJ, et al. Characterization of Torin2, an ATP-competitive inhibitor of mTOR, ATM, and ATR. Cancer Research. 73: 2574-86. PMID 23436801 DOI: 10.1158/0008-5472.CAN-12-1702  1
2013 Solimini NL, Liang AC, Xu C, Pavlova NN, Xu Q, Davoli T, Li MZ, Wong KK, Elledge SJ. STOP gene Phactr4 is a tumor suppressor. Proceedings of the National Academy of Sciences of the United States of America. 110: E407-14. PMID 23319639 DOI: 10.1073/pnas.1221385110  1
2013 Wang CI, Alekseyenko AA, LeRoy G, Elia AE, Gorchakov AA, Britton LM, Elledge SJ, Kharchenko PV, Garcia BA, Kuroda MI. Chromatin proteins captured by ChIP-mass spectrometry are linked to dosage compensation in Drosophila. Nature Structural & Molecular Biology. 20: 202-9. PMID 23295261 DOI: 10.1038/nsmb.2477  1
2012 Larman HB, Xu GJ, Pavlova NN, Elledge SJ. Construction of a rationally designed antibody platform for sequencing-assisted selection Proceedings of the National Academy of Sciences of the United States of America. 109: 18523-18528. PMID 23064642 DOI: 10.1073/pnas.1215549109  1
2012 Tan X, Hu L, Luquette LJ, Gao G, Liu Y, Qu H, Xi R, Lu ZJ, Park PJ, Elledge SJ. Systematic identification of synergistic drug pairs targeting HIV. Nature Biotechnology. 30: 1125-30. PMID 23064238 DOI: 10.1038/nbt.2391  1
2012 Zhu J, Gaiha GD, John SP, Pertel T, Chin CR, Gao G, Qu H, Walker BD, Elledge SJ, Brass AL. Reactivation of latent HIV-1 by inhibition of BRD4. Cell Reports. 2: 807-16. PMID 23041316 DOI: 10.1016/j.celrep.2012.09.008  1
2012 Ciccia A, Nimonkar AV, Hu Y, Hajdu I, Achar YJ, Izhar L, Petit SA, Adamson B, Yoon JC, Kowalczykowski SC, Livingston DM, Haracska L, Elledge SJ. Polyubiquitinated PCNA recruits the ZRANB3 translocase to maintain genomic integrity after replication stress. Molecular Cell. 47: 396-409. PMID 22704558 DOI: 10.1016/j.molcel.2012.05.024  1
2012 Solimini NL, Xu Q, Mermel CH, Liang AC, Schlabach MR, Luo J, Burrows AE, Anselmo AN, Bredemeyer AL, Li MZ, Beroukhim R, Meyerson M, Elledge SJ. Recurrent hemizygous deletions in cancers may optimize proliferative potential. Science (New York, N.Y.). 337: 104-9. PMID 22628553 DOI: 10.1126/science.1219580  1
2012 Elia AEH, Elledge SJ. BRCA1 as tumor suppressor: Lord without its RING? Breast Cancer Research. 14. PMID 22494569 DOI: 10.1186/bcr3118  1
2012 Aceto N, Sausgruber N, Brinkhaus H, Gaidatzis D, Martiny-Baron G, Mazzarol G, Confalonieri S, Quarto M, Hu G, Balwierz PJ, Pachkov M, Elledge SJ, Van Nimwegen E, Stadler MB, Bentires-Alj M. Tyrosine phosphatase SHP2 promotes breast cancer progression and maintains tumor-initiating cells via activation of key transcription factors and a positive feedback signaling loop Nature Medicine. 18: 529-537. PMID 22388088 DOI: 10.1038/nm.2645  1
2012 Adamson B, Smogorzewska A, Sigoillot FD, King RW, Elledge SJ. A genome-wide homologous recombination screen identifies the RNA-binding protein RBMX as a component of the DNA-damage response. Nature Cell Biology. 14: 318-28. PMID 22344029 DOI: 10.1038/ncb2426  1
2012 Li MZ, Elledge SJ. SLIC: A method for sequence- and ligation-independent cloning Methods in Molecular Biology. 852: 51-59. PMID 22328425 DOI: 10.1007/978-1-61779-564-0_5  1
2012 Tan X, Lu ZJ, Gao G, Xu Q, Hu L, Fellmann C, Li MZ, Qu H, Lowe SW, Hannon GJ, Elledge SJ. Tiling genomes of pathogenic viruses identifies potent antiviral shRNAs and reveals a role for secondary structure in shRNA efficacy Proceedings of the National Academy of Sciences of the United States of America. 109: 869-874. PMID 22219365 DOI: 10.1073/pnas.1119873109  1
2012 Kessler JD, Kahle KT, Sun T, Meerbrey KL, Schlabach MR, Schmitt EM, Skinner SO, Xu Q, Li MZ, Hartman ZC, Rao M, Yu P, Dominguez-Vidana R, Liang AC, Solimini NL, ... ... Elledge SJ, et al. A SUMOylation-dependent transcriptional subprogram is required for Myc-driven tumorigenesis. Science (New York, N.Y.). 335: 348-53. PMID 22157079 DOI: 10.1126/science.1212728  1
2011 Feeley EM, Sims JS, John SP, Chin CR, Pertel T, Chen LM, Gaiha GD, Ryan BJ, Donis RO, Elledge SJ, Brass AL. IFITM3 inhibits influenza A virus infection by preventing cytosolic entry. Plos Pathogens. 7: e1002337. PMID 22046135 DOI: 10.1371/journal.ppat.1002337  1
2011 Emanuele MJ, Elia AEH, Xu Q, Thoma CR, Izhar L, Leng Y, Guo A, Chen YN, Rush J, Hsu PWC, Yen HCS, Elledge SJ. Global identification of modular cullin-RING ligase substrates Cell. 147: 459-474. PMID 21963094 DOI: 10.1016/j.cell.2011.09.019  1
2011 Hajdu I, Ciccia A, Lewis SM, Elledge SJ. Wolf - Hirschhorn syndrome candidate 1 is involved in the cellular response to DNA damage Proceedings of the National Academy of Sciences of the United States of America. 108: 13130-13134. PMID 21788515 DOI: 10.1073/pnas.1110081108  1
2011 Joo W, Xu G, Persky NS, Smogorzewska A, Rudge DG, Buzovetsky O, Elledge SJ, Pavletich NP. Structure of the FANCI-FANCD2 complex: Insights into the Fanconi anemia DNA repair pathway Science. 333: 312-316. PMID 21764741 DOI: 10.1126/science.1205805  1
2011 Cotta-Ramusino C, McDonald ER, Hurov K, Sowa ME, Harper JW, Elledge SJ. A DNA damage response screen identifies RHINO, a 9-1-1 and topBP1 interacting protein required for ATR signaling Science. 332: 1313-1317. PMID 21659603 DOI: 10.1126/science.1203430  1
2011 Emanuele MJ, Ciccia A, Elia AEH, Elledge SJ. Proliferating cell nuclear antigen (PCNA)-associated KIAA0101/PAF15 protein is a cell cycle-regulated anaphase-promoting complex/cyclosome substrate Proceedings of the National Academy of Sciences of the United States of America. 108: 9845-9850. PMID 21628590 DOI: 10.1073/pnas.1106136108  1
2011 Larman HB, Zhao Z, Laserson U, Li MZ, Ciccia A, Gakidis MA, Church GM, Kesari S, Leproust EM, Solimini NL, Elledge SJ. Autoantigen discovery with a synthetic human peptidome. Nature Biotechnology. 29: 535-41. PMID 21602805 DOI: 10.1038/nbt.1856  1
2011 Sun T, Aceto N, Meerbrey KL, Kessler JD, Zhou C, Migliaccio I, Nguyen DX, Pavlova NN, Botero M, Huang J, Bernardi RJ, Schmitt E, Hu G, Li MZ, Dephoure N, ... ... Elledge SJ, et al. Activation of multiple proto-oncogenic tyrosine kinases in breast cancer via loss of the PTPN12 phosphatase. Cell. 144: 703-18. PMID 21376233 DOI: 10.1016/j.cell.2011.02.003  1
2011 Fellmann C, Zuber J, McJunkin K, Chang K, Malone CD, Dickins RA, Xu Q, Hengartner MO, Elledge SJ, Hannon GJ, Lowe SW. Functional identification of optimized RNAi triggers using a massively parallel sensor assay. Molecular Cell. 41: 733-46. PMID 21353615 DOI: 10.1016/j.molcel.2011.02.008  1
2011 Meerbrey KL, Hu G, Kessler JD, Roarty K, Li MZ, Fang JE, Herschkowitz JI, Burrows AE, Ciccia A, Sun T, Schmitt EM, Bernardi RJ, Fu X, Bland CS, Cooper TA, ... ... Elledge SJ, et al. The pINDUCER lentiviral toolkit for inducible RNA interference in vitro and in vivo. Proceedings of the National Academy of Sciences of the United States of America. 108: 3665-70. PMID 21307310 DOI: 10.1073/pnas.1019736108  1
2011 Huang IC, Bailey CC, Weyer JL, Radoshitzky SR, Becker MM, Chiang JJ, Brass AL, Ahmed AA, Chi X, Dong L, Longobardi LE, Boltz D, Kuhn JH, Elledge SJ, Bavari S, et al. Distinct patterns of IFITM-mediated restriction of filoviruses, SARS coronavirus, and influenza A virus. Plos Pathogens. 7: e1001258. PMID 21253575 DOI: 10.1371/journal.ppat.1001258  1
2010 Kapitzky L, Beltrao P, Berens TJ, Gassner N, Zhou C, Wüster A, Wu J, Babu MM, Elledge SJ, Toczyski D, Lokey RS, Krogan NJ. Cross-species chemogenomic profiling reveals evolutionarily conserved drug mode of action. Molecular Systems Biology. 6: 451. PMID 21179023 DOI: 10.1038/msb.2010.107  1
2010 O'Connell BC, Adamson B, Lydeard JR, Sowa ME, Ciccia A, Bredemeyer AL, Schlabach M, Gygi SP, Elledge SJ, Harper J. Wade JW. A Genome-wide Camptothecin Sensitivity Screen Identifies a Mammalian MMS22L-NFKBIL2 Complex Required for Genomic Stability Molecular Cell. 40: 645-657. PMID 21055985 DOI: 10.1016/j.molcel.2010.10.022  1
2010 Ciccia A, Elledge SJ. The DNA Damage Response: Making It Safe to Play with Knives Molecular Cell. 40: 179-204. PMID 20965415 DOI: 10.1016/j.molcel.2010.09.019  1
2010 Chou DM, Adamson B, Dephoure NE, Tan X, Nottke AC, Hurov KE, Gygi SP, Colaiácovo MP, Elledge SJ. A chromatin localization screen reveals poly (ADP ribose)-regulated recruitment of the repressive polycomb and NuRD complexes to sites of DNA damage Proceedings of the National Academy of Sciences of the United States of America. 107: 18475-18480. PMID 20937877 DOI: 10.1073/pnas.1012946107  1
2010 Hurov KE, Cotta-Ramusino C, Elledge SJ. A genetic screen identifies the Triple T complex required for DNA damage signaling and ATM and ATR stability Genes and Development. 24: 1939-1950. PMID 20810650 DOI: 10.1101/gad.1934210  1
2010 Burrows AE, Smogorzewska A, Elledge SJ. Polybromo-associated BRG1-associated factor components BRD7 and BAF180 are critical regulators of p53 required for induction of replicative senescence Proceedings of the National Academy of Sciences of the United States of America. 107: 14280-14285. PMID 20660729 DOI: 10.1073/pnas.1009559107  1
2010 Yoon JC, Ng A, Kim BH, Bianco A, Xavier RJ, Elledge SJ. Wnt signaling regulates mitochondrial physiology and insulin sensitivity Genes and Development. 24: 1507-1518. PMID 20634317 DOI: 10.1101/gad.1924910  1
2010 Smogorzewska A, Desetty R, Saito TT, Schlabach M, Lach FP, Sowa ME, Clark AB, Kunkel TA, Harper JW, Colaiácovo MP, Elledge SJ. A Genetic Screen Identifies FAN1, a Fanconi Anemia-Associated Nuclease Necessary for DNA Interstrand Crosslink Repair Molecular Cell. 39: 36-47. PMID 20603073 DOI: 10.1016/j.molcel.2010.06.023  1
2010 Song EJ, Werner SL, Neubauer J, Stegmeier F, Aspden J, Rio D, Harper JW, Elledge SJ, Kirschner MW, Rape M. The Prp19 complex and the Usp4Sart3 deubiquitinating enzyme control reversible ubiquitination at the spliceosome. Genes & Development. 24: 1434-47. PMID 20595234 DOI: 10.1101/gad.1925010  1
2010 Fishler T, Li YY, Wang RH, Kim HS, Sengupta K, Vassilopoulos A, Lahusen T, Xu X, Lee MH, Liu Q, Elledge SJ, Ried T, Deng CX. Genetic instability and mammary tumor formation in mice carrying mammary-specific disruption of Chk1 and p53. Oncogene. 29: 4007-17. PMID 20473325 DOI: 10.1038/onc.2010.163  1
2010 Swedlow JR, Cotta-Ramusino C, Elledge SJ. Cell biology forum: Genome-wide view of mitosis Nature. 464: 684-685. PMID 20360724 DOI: 10.1038/464684a  1
2010 Schlabach MR, Hu JK, Li M, Elledge SJ. Synthetic design of strong promoters Proceedings of the National Academy of Sciences of the United States of America. 107: 2538-2543. PMID 20133776 DOI: 10.1073/pnas.0914803107  1
2009 Brass AL, Huang IC, Benita Y, John SP, Krishnan MN, Feeley EM, Ryan BJ, Weyer JL, van der Weyden L, Fikrig E, Adams DJ, Xavier RJ, Farzan M, Elledge SJ. The IFITM Proteins Mediate Cellular Resistance to Influenza A H1N1 Virus, West Nile Virus, and Dengue Virus Cell. 139: 1243-1254. PMID 20064371 DOI: 10.1016/j.cell.2009.12.017  1
2009 Knipscheer P, Räschle M, Smogorzewska A, Enoiu M, Ho TV, Schärer OD, Elledge SJ, Walter JC. The Fanconi anemia pathway promotes replication-dependent DNA interstrand cross-link repair. Science (New York, N.Y.). 326: 1698-701. PMID 19965384 DOI: 10.1126/science.1182372  1
2009 Ciccia A, Bredemeyer AL, Sowa ME, Terret ME, Jallepalli PV, Harper JW, Elledge SJ. The SIOD disorder protein SMARCAL1 is an RPA-interacting protein involved in replication fork restart Genes and Development. 23: 2415-2425. PMID 19793862 DOI: 10.1101/gad.1832309  1
2009 Shen X, Do H, Li Y, Chung WH, Tomasz M, de Winter JP, Xia B, Elledge SJ, Wang W, Li L. Recruitment of Fanconi Anemia and Breast Cancer Proteins to DNA Damage Sites Is Differentially Governed by Replication Molecular Cell. 35: 716-723. PMID 19748364 DOI: 10.1016/j.molcel.2009.06.034  1
2009 Li Q, Brass AL, Ng A, Hu Z, Xavier RJ, Liang TJ, Elledge SJ. A genome-wide genetic screen for host factors required for hepatitis C virus propagation Proceedings of the National Academy of Sciences of the United States of America. 106: 16410-16415. PMID 19717417 DOI: 10.1073/pnas.0907439106  1
2009 Svendsen JM, Smogorzewska A, Sowa ME, O'Connell BC, Gygi SP, Elledge SJ, Harper JW. Mammalian BTBD12/SLX4 Assembles A Holliday Junction Resolvase and Is Required for DNA Repair Cell. 138: 63-77. PMID 19596235 DOI: 10.1016/j.cell.2009.06.030  1
2009 Naylor ML, Li JM, Osborn AJ, Elledge SJ. Mrc1 phosphorylation in response to DNA replication stress is required for Mec1 accumulation at the stalled fork. Proceedings of the National Academy of Sciences of the United States of America. 106: 12765-70. PMID 19515819 DOI: 10.1073/pnas.0904623106  1
2009 Luo J, Emanuele MJ, Li D, Creighton CJ, Schlabach MR, Westbrook TF, Wong KK, Elledge SJ. A Genome-wide RNAi Screen Identifies Multiple Synthetic Lethal Interactions with the Ras Oncogene Cell. 137: 835-848. PMID 19490893 DOI: 10.1016/j.cell.2009.05.006  1
2009 Hu G, Kim J, Xu Q, Leng Y, Orkin SH, Elledge SJ. A genome-wide RNAi screen identifies a new transcriptional module required for self-renewal Genes and Development. 23: 837-848. PMID 19339689 DOI: 10.1101/gad.1769609  1
2009 Luo J, Solimini NL, Elledge SJ. Principles of cancer therapy: oncogene and non-oncogene addiction. Cell. 136: 823-37. PMID 19269363 DOI: 10.1016/j.cell.2009.02.024  1
2009 Wang B, Hurov K, Hofmann K, Elledge SJ. NBA1, a new player in the Brcal A complex, is required for DNA damage resistance and checkpoint control Genes and Development. 23: 729-739. PMID 19261749 DOI: 10.1101/gad.1770309  1
2009 Xu Q, Schlabach MR, Hannon GJ, Elledge SJ. Design of 240,000 orthogonal 25mer DNA barcode probes Proceedings of the National Academy of Sciences of the United States of America. 106: 2289-2294. PMID 19171886 DOI: 10.1073/pnas.0812506106  1
2009 Zhang L, Lee SY, Beznoussenko GV, Peters PJ, Yang JS, Gilbert HY, Brassd AL, Elledge SJ, Isaacs SN, Moss B, Mironov A, Hsu VW. A role for the host coatomer and KDEL receptor in early vaccinia biogenesis Proceedings of the National Academy of Sciences of the United States of America. 106: 163-168. PMID 19109439 DOI: 10.1073/pnas.0811631106  1
2009 Xiao A, Li H, Shechter D, Ahn SH, Fabrizio LA, Erdjument-Bromage H, Ishibe-Murakami S, Wang B, Tempst P, Hofmann K, Patel DJ, Elledge SJ, Allis CD. WSTF regulates the H2A.X DNA damage response via a novel tyrosine kinase activity. Nature. 457: 57-62. PMID 19092802 DOI: 10.1038/nature07668  1
2009 Luo J, Solimini NL, Elledge SJ. Principles of Cancer Therapy: Oncogene and Non-oncogene Addiction (DOI:10.1016/j.cell.2009.02.024) Cell. 138: 807. DOI: 10.1016/j.cell.2009.08.006  1
2008 Mulligan P, Westbrook TF, Ottinger M, Pavlova N, Chang B, Macia E, Shi YJ, Barretina J, Liu J, Howley PM, Elledge SJ, Shi Y. CDYL Bridges REST and Histone Methyltransferases for Gene Repression and Suppression of Cellular Transformation Molecular Cell. 32: 718-726. PMID 19061646 DOI: 10.1016/j.molcel.2008.10.025  1
2008 Collis SJ, Ciccia A, Deans AJ, Ho?ejší Z, Martin JS, Maslen SL, Skehel JM, Elledge SJ, West SC, Boulton SJ. FANCM and FAAP24 Function in ATR-Mediated Checkpoint Signaling Independently of the Fanconi Anemia Core Complex Molecular Cell. 32: 313-324. PMID 18995830 DOI: 10.1016/j.molcel.2008.10.014  1
2008 Yen HCS, Elledge SJ. Identification of SCF ubiquitin ligase substrates by global protein stability profiling Science. 322: 923-929. PMID 18988848 DOI: 10.1126/science.1160462  1
2008 Yen HCS, Xu Q, Chou DM, Zhao Z, Elledge SJ. Global protein stability profiling in mammalian cells Science. 322: 918-923. PMID 18988847 DOI: 10.1126/science.1160489  1
2008 Li JM, Tetzlaff MT, Elledge SJ. Identification of MSA1, a cell cycle-regulated, dosage suppressor of drc1/sld2 and dpb11 mutants Cell Cycle. 7: 3388-3398. PMID 18948746  1
2008 Ishiai M, Kitao H, Smogorzewska A, Tomida J, Kinomura A, Uchida E, Saberi A, Kinoshita E, Kinoshita-Kikuta E, Koike T, Tashiro S, Elledge SJ, Takata M. FANCI phosphorylation functions as a molecular switch to turn on the Fanconi anemia pathway Nature Structural and Molecular Biology. 15: 1138-1146. PMID 18931676 DOI: 10.1038/nsmb.1504  1
2008 Lee YD, Wang J, Stubbe J, Elledge SJ. Dif1 is a DNA-damage-regulated facilitator of nuclear import for ribonucleotide reductase. Molecular Cell. 32: 70-80. PMID 18851834 DOI: 10.1016/j.molcel.2008.08.018  1
2008 Krishnan MN, Ng A, Sukumaran B, Gilfoy FD, Uchil PD, Sultana H, Brass AL, Adametz R, Tsui M, Qian F, Montgomery RR, Lev S, Mason PW, Koski RA, Elledge SJ, et al. RNA interference screen for human genes associated with West Nile virus infection. Nature. 455: 242-5. PMID 18690214 DOI: 10.1038/nature07207  1
2008 Dephoure N, Zhou C, Villén J, Beausoleil SA, Bakalarski CE, Elledge SJ, Gygi SP. A quantitative atlas of mitotic phosphorylation Proceedings of the National Academy of Sciences of the United States of America. 105: 10762-10767. PMID 18669648 DOI: 10.1073/pnas.0805139105  1
2008 Luo J, Elledge SJ. Cancer: Deconstructing oncogenesis Nature. 453: 995-996. PMID 18563141 DOI: 10.1038/453995a  1
2008 Burrows AE, Elledge SJ. How ATR turns on: TopBP1 goes on ATRIP with ATR Genes and Development. 22: 1416-1421. PMID 18519633 DOI: 10.1101/gad.1685108  1
2008 Westbrook TF, Hu G, Ang XL, Mulligan P, Pavlova NN, Liang A, Leng Y, Maehr R, Shi Y, Harper JW, Elledge SJ. SCFβ-TRCP controls oncogenic transformation and neural differentiation through REST degradation Nature. 452: 370-374. PMID 18354483 DOI: 10.1038/nature06780  1
2008 Schlabach MR, Luo J, Solimini NL, Hu G, Xu Q, Li MZ, Zhao Z, Smogorzewska A, Sowa ME, Ang XL, Westbrook TF, Liang AC, Chang K, Hackett JA, Harper JW, ... ... Elledge SJ, et al. Cancer proliferation gene discovery through functional genomics Science. 319: 620-624. PMID 18239126 DOI: 10.1126/science.1149200  1
2008 Schlabach MR, Luo J, Solimini NL, Hu G, Xu Q, Li MZ, Zhao Z, Smogorzewska A, Sowa ME, Ang XL, Westbrook TF, Liang AC, Chang K, Hackett JA, Harper JW, ... ... Elledge SJ, et al. Cancer proliferation gene discovery through functional genomics Science. 319: 620-624. PMID 18239126 DOI: 10.1126/science.1149200  1
2008 Silva JM, Marran K, Parker JS, Silva J, Golding M, Schlabach MR, Elledge SJ, Hannon GJ, Chang K. Profiling essential genes in human mammary cells by multiplex RNAi screening Science. 319: 617-620. PMID 18239125 DOI: 10.1126/science.1149185  1
2008 Brass AL, Dykxhoorn DM, Benita Y, Yan N, Engelman A, Xavier RJ, Lieberman J, Elledge SJ. Identification of host proteins required for HIV infection through a functional genomic screen. Science (New York, N.Y.). 319: 921-6. PMID 18187620 DOI: 10.1126/science.1152725  0.52
2007 Harper JW, Elledge SJ. The DNA Damage Response: Ten Years After Molecular Cell. 28: 739-745. PMID 18082599 DOI: 10.1016/j.molcel.2007.11.015  1
2007 Wang B, Elledge SJ. Ubc13/Rnf8 ubiquitin ligases control foci formation of the Rap80/Abraxas/Brca1/Brcc36 complex in response to DNA damage Proceedings of the National Academy of Sciences of the United States of America. 104: 20759-20763. PMID 18077395 DOI: 10.1073/pnas.0710061104  1
2007 Stewart GS, Stankovic T, Byrd PJ, Wechsler T, Miller ES, Huissoon A, Drayson MT, West SC, Elledge SJ, Taylor AM. RIDDLE immunodeficiency syndrome is linked to defects in 53BP1-mediated DNA damage signaling. Proceedings of the National Academy of Sciences of the United States of America. 104: 16910-5. PMID 17940005 DOI: 10.1073/pnas.0708408104  1
2007 Stewart GS, Stankovic T, Byrd PJ, Wechsler T, Miller ES, Huissoon A, Drayson MT, West SC, Elledge SJ, Taylor AM. RIDDLE immunodeficiency syndrome is linked to defects in 53BP1-mediated DNA damage signaling. Proceedings of the National Academy of Sciences of the United States of America. 104: 16910-5. PMID 17940005 DOI: 10.1073/pnas.0708408104  1
2007 Solimini NL, Luo J, Elledge SJ. Non-Oncogene Addiction and the Stress Phenotype of Cancer Cells Cell. 130: 986-988. PMID 17889643 DOI: 10.1016/j.cell.2007.09.007  1
2007 Popov N, Wanzel M, Madiredjo M, Zhang D, Beijersbergen R, Bernards R, Moll R, Elledge SJ, Eilers M. The ubiquitin-specific protease USP28 is required for MYC stability. Nature Cell Biology. 9: 765-74. PMID 17558397 DOI: 10.1038/ncb1601  1
2007 Popov N, Wanzel M, Madiredjo M, Zhang D, Beijersbergen R, Bernards R, Moll R, Elledge SJ, Eilers M. The ubiquitin-specific protease USP28 is required for MYC stability. Nature Cell Biology. 9: 765-74. PMID 17558397 DOI: 10.1038/ncb1601  1
2007 Wang B, Matsuoka S, Ballif BA, Zhang D, Smogorzewska A, Gygi SP, Elledge SJ. Abraxas and RAP80 form a BRCA1 protein complex required for the DNA damage response Science. 316: 1194-1198. PMID 17525340 DOI: 10.1126/science.1139476  1
2007 Matsuoka S, Ballif BA, Smogorzewska A, McDonald ER, Hurov KE, Luo J, Bakalarski CE, Zhao Z, Solimini N, Lerenthal Y, Shiloh Y, Gygi SP, Elledge SJ. ATM and ATR substrate analysis reveals extensive protein networks responsive to DNA damage Science. 316: 1160-1166. PMID 17525332 DOI: 10.1126/science.1140321  1
2007 Stegmeier F, Sowa ME, Nalepa G, Gygi SP, Harper JW, Elledge SJ. The tumor suppressor CYLD regulates entry into mitosis Proceedings of the National Academy of Sciences of the United States of America. 104: 8869-8874. PMID 17495026 DOI: 10.1073/pnas.0703268104  1
2007 Stegmeier F, Rape M, Draviam VM, Nalepa G, Sowa ME, Ang XL, McDonald ER, Li MZ, Hannon GJ, Sorger PK, Kirschner MW, Harper JW, Elledge SJ. Anaphase initiation is regulated by antagonistic ubiquitination and deubiquitination activities. Nature. 446: 876-81. PMID 17443180 DOI: 10.1038/nature05694  1
2007 Draviam VM, Stegmeier F, Nalepa G, Sowa ME, Chen J, Liang A, Hannon GJ, Sorger PK, Harper JW, Elledge SJ. A functional genomic screen identifies a role for TAO1 kinase in spindle-checkpoint signalling. Nature Cell Biology. 9: 556-64. PMID 17417629 DOI: 10.1038/ncb1569  1
2007 Smogorzewska A, Matsuoka S, Vinciguerra P, McDonald ER, Hurov KE, Luo J, Ballif BA, Gygi SP, Hofmann K, D'Andrea AD, Elledge SJ. Identification of the FANCI protein, a monoubiquitinated FANCD2 paralog required for DNA repair. Cell. 129: 289-301. PMID 17412408 DOI: 10.1016/j.cell.2007.03.009  1
2007 Zaugg K, Su YW, Reilly PT, Moolani Y, Cheung CC, Hakem R, Hirao A, Liu Q, Elledge SJ, Mak TW. Cross-talk between Chk1 and Chk2 in double-mutant thymocytes. Proceedings of the National Academy of Sciences of the United States of America. 104: 3805-10. PMID 17360434 DOI: 10.1073/pnas.0611584104  1
2007 Li MZ, Elledge SJ. Harnessing homologous recombination in vitro to generate recombinant DNA via SLIC Nature Methods. 4: 251-256. PMID 17293868 DOI: 10.1038/nmeth1010  1
2007 Stegmeier F, Rape M, Draviam VM, Nalepa G, Sowa ME, Ang XL, McDonald ER, Li MZ, Hannon GJ, Sorger PK, Kirschner MW, Harper JW, Elledge SJ. Anaphase initiation is regulated by antagonistic ubiquitination and deubiquitination activities Nature. 447: 876-881.  1
2007 Stegmeier F, Rape M, Draviam VM, Nalepa G, Sowa ME, Ang XL, McDonald ER, Li MZ, Hannon GJ, Sorger PK, Kirschner MW, Harper JW, Elledge SJ. Anaphase initiation is regulated by antagonistic ubiquitination and deubiquitination activities Nature. 447: 876-881.  1
2006 Chou DM, Elledge SJ. Tipin and Timeless form a mutually protective complex required for genotoxic stress resistance and checkpoint function Proceedings of the National Academy of Sciences of the United States of America. 103: 18143-18147. PMID 17116885 DOI: 10.1073/pnas.0609251103  1
2006 Chang K, Elledge SJ, Hannon GJ. Lessons from Nature: microRNA-based shRNA libraries Nature Methods. 3: 707-714. PMID 16929316 DOI: 10.1038/nmeth923  1
2006 Zhang D, Zaugg K, Mak TW, Elledge SJ. A Role for the Deubiquitinating Enzyme USP28 in Control of the DNA-Damage Response Cell. 126: 529-542. PMID 16901786 DOI: 10.1016/j.cell.2006.06.039  1
2006 Wang X, Zou L, Lu T, Bao S, Hurov KE, Hittelman WN, Elledge SJ, Li L. Rad17 Phosphorylation Is Required for Claspin Recruitment and Chk1 Activation in Response to Replication Stress Molecular Cell. 23: 331-341. PMID 16885023 DOI: 10.1016/j.molcel.2006.06.022  1
2006 Cao L, Kim S, Xiao C, Wang RH, Coumoul X, Wang X, Li WM, Xu XL, De Soto JA, Takai H, Mai S, Elledge SJ, Motoyama N, Deng CX. ATM-Chk2-p53 activation prevents tumorigenesis at an expense of organ homeostasis upon Brca1 deficiency. The Embo Journal. 25: 2167-77. PMID 16675955 DOI: 10.1038/sj.emboj.7601115  1
2006 Lee YD, Elledge SJ. Control of ribonucleotide reductase localization through an anchoring mechanism involving Wtm1 Genes and Development. 20: 334-344. PMID 16452505 DOI: 10.1101/gad.1380506  1
2005 Westbrook TF, Stegmeier F, Elledge SJ. Dissecting cancer pathways and vulnerabilities with RNAi Cold Spring Harbor Symposia On Quantitative Biology. 70: 435-444. PMID 16869781 DOI: 10.1101/sqb.2005.70.031  1
2005 Turnell AS, Stewart GS, Grand RJA, Rookes SM, Martin A, Yamano H, Elledge SJ, Gallimore PH. The APC/C and CBP/p300 cooperate to regulate transcription and cell-cycle progression Nature. 438: 690-695. PMID 16319895 DOI: 10.1038/nature04151  1
2005 Adams MM, Wang B, Xia Z, Morales JC, Lu X, Donehower LA, Bochar DA, Elledge SJ, Carpenter PB. 53BP1 oligomerization is independent of its methylation by PRMT1. Cell Cycle (Georgetown, Tex.). 4: 1854-61. PMID 16294047  1
2005 Elledge SJ, Hannon GJ. An open letter to cancer researchers [1] Science. 310: 439-441. PMID 16239460  1
2005 Lin SY, Rai R, Li K, Xu ZX, Elledge SJ. BRIT1/MCPH1 is a DNA damage responsive protein that regulates the Brca1-Chk1 pathway, implicating checkpoint dysfunction in microcephaly Proceedings of the National Academy of Sciences of the United States of America. 102: 15105-15109. PMID 16217032 DOI: 10.1073/pnas.0507722102  1
2005 Silva JM, Li MZ, Chang K, Ge W, Golding MC, Rickles RJ, Siolas D, Hu G, Paddison PJ, Schlabach MR, Sheth N, Bradshaw J, Burchard J, Kulkarni A, Cavet G, ... ... Elledge SJ, et al. Second-generation shRNA libraries covering the mouse and human genomes. Nature Genetics. 37: 1281-8. PMID 16200065 DOI: 10.1038/ng1650  1
2005 Perry KL, Elledge SJ, Mitchell BB, Marsh L, Walker GC. umuDC and mucAB operons whose products are required for UV light- and chemical-induced mutagenesis: UmuD, MucA, and LexA proteins share homology. 1985. Dna Repair. 4: 1054-8. PMID 16196126  1
2005 Stegmeier F, Hu G, Rickles RJ, Hannon GJ, Elledge SJ. A lentiviral microRNA-based system for single-copy polymerase II-regulated RNA interference in mammalian cells. Proceedings of the National Academy of Sciences of the United States of America. 102: 13212-7. PMID 16141338 DOI: 10.1073/pnas.0506306102  1
2005 Westbrook TF, Martin ES, Schlabach MR, Leng Y, Liang AC, Feng B, Zhao JJ, Roberts TM, Mandel G, Hannon GJ, Depinho RA, Chin L, Elledge SJ. A genetic screen for candidate tumor suppressors identifies REST. Cell. 121: 837-48. PMID 15960972 DOI: 10.1016/j.cell.2005.03.033  1
2005 Altman S, Bassler BL, Beckwith J, Belfort M, Berg HC, Bloom B, Brenchley JE, Campbell A, Collier RJ, Connell N, Cozzarelli NR, Craig NL, Darst S, Ebright RH, Elledge SJ, et al. An open letter to Elias Zerhouni. Science (New York, N.Y.). 307: 1409-10. PMID 15746409 DOI: 10.1126/science.307.5714.1409c  1
2005 Li MZ, Elledge SJ. MAGIC, an in vivo genetic method for the rapid construction of recombinant DNA molecules Nature Genetics. 37: 311-319. PMID 15731760 DOI: 10.1038/ng1505  1
2005 Li JM, Li Y, Elledge SJ. Genetic analysis of the kinetochore DASH complex reveals an antagonistic relationship with the Ras/protein kinase A pathway and a novel subunit required for Ask1 association Molecular and Cellular Biology. 25: 767-778. PMID 15632076 DOI: 10.1128/MCB.25.2.767-778.2005  1
2004 Jin J, Cardozo T, Lovering RC, Elledge SJ, Pagano M, Harper JW. Systematic analysis and nomenclature of mammalian F-box proteins. Genes & Development. 18: 2573-80. PMID 15520277 DOI: 10.1101/gad.1255304  1
2004 Ye X, Nalepa G, Welcker M, Kessler BM, Spooner E, Qin J, Elledge SJ, Clurman BE, Harper JW. Recognition of phosphodegron motifs in human cyclin E by the SCF Fbw7 ubiquitin ligase Journal of Biological Chemistry. 279: 50110-50119. PMID 15364936 DOI: 10.1074/jbc.M409226200  1
2004 Lam MH, Liu Q, Elledge SJ, Rosen JM. Chk1 is haploinsufficient for multiple functions critical to tumor suppression. Cancer Cell. 6: 45-59. PMID 15261141 DOI: 10.1016/j.ccr.2004.06.015  1
2004 Cortez D, Glick G, Elledge SJ. Minichromosome maintenance proteins are direct targets of the ATM and ATR checkpoint kinases Proceedings of the National Academy of Sciences of the United States of America. 101: 10078-10083. PMID 15210935 DOI: 10.1073/pnas.0403410101  1
2004 Lin SY, Li K, Stewart GS, Elledge SJ. Human Claspin works with BRCA1 to both positively and negatively regulate cell proliferation Proceedings of the National Academy of Sciences of the United States of America. 101: 6484-6489. PMID 15096610 DOI: 10.1073/pnas.0401847101  1
2004 Paddison PJ, Silva JM, Conklin DS, Schlabach M, Li M, Aruleba S, Balija V, O'Shaughnessy A, Gnoj L, Scobie K, Chang K, Westbrook T, Cleary M, Sachidanandam R, McCombie WR, ... Elledge SJ, et al. A resource for large-scale RNA-interference-based screens in mammals. Nature. 428: 427-31. PMID 15042091 DOI: 10.1038/nature02370  1
2004 Tetzlaff MT, Bai C, Finegold M, Wilson J, Harper JW, Mahon KA, Elledge SJ. Cyclin F Disruption Compromises Placental Development and Affects Normal Cell Cycle Execution Molecular and Cellular Biology. 24: 2487-2498. PMID 14993286 DOI: 10.1128/MCB.24.6.2487-2498.2004  1
2004 Tetzlaff MT, Yu W, Li M, Zhang P, Finegold M, Mahon K, Harper JW, Schwartz RJ, Elledge SJ. Defective cardiovascular development and elevated cyclin E and Notch proteins in mice lacking the Fbw7 F-box protein Proceedings of the National Academy of Sciences of the United States of America. 101: 3338-3345. PMID 14766969 DOI: 10.1073/pnas.0307875101  1
2003 Jin J, Shirogane T, Xu L, Nalepa G, Qin J, Elledge SJ, Harper JW. SCFbeta-TRCP links Chk1 signaling to degradation of the Cdc25A protein phosphatase. Genes & Development. 17: 3062-74. PMID 14681206 DOI: 10.1101/gad.1157503  1
2003 Zou L, Liu D, Elledge SJ. Replication protein A-mediated recruitment and activation of Rad17 complexes Proceedings of the National Academy of Sciences of the United States of America. 100: 13827-13832. PMID 14605214 DOI: 10.1073/pnas.2336100100  1
2003 Bernstein E, Kim SY, Carmell MA, Murchison EP, Alcorn H, Li MZ, Mills AA, Elledge SJ, Anderson KV, Hannon GJ. Dicer is essential for mouse development. Nature Genetics. 35: 215-7. PMID 14528307 DOI: 10.1038/ng1253  1
2003 Xu L, Wei Y, Reboul J, Vaglio P, Shin TH, Vidal M, Elledge SJ, Harper JW. BTB proteins are substrate-specific adaptors in an SCF-like modular ubiquitin ligase containing CUL-3. Nature. 425: 316-21. PMID 13679922 DOI: 10.1038/nature01985  1
2003 Osborn AJ, Elledge SJ. Mrc1 is a replication fork component whose phosphorylation in response to DNA replication stress activates Rad53 Genes and Development. 17: 1755-1767. PMID 12865299 DOI: 10.1101/gad.1098303  1
2003 Lin SY, Elledge SJ. Multiple tumor suppressor pathways negatively regulate telomerase Cell. 113: 881-889. PMID 12837246 DOI: 10.1016/S0092-8674(03)00430-6  1
2003 Zou L, Elledge SJ. Sensing DNA damage through ATRIP recognition of RPA-ssDNA complexes Science. 300: 1542-1548. PMID 12791985 DOI: 10.1126/science.1083430  1
2003 Li Y, Elledge SJ. The DASH complex component Ask1 is a cell cycle-regulated Cdk substrate in Saccharomyces cerevisiae Cell Cycle (Georgetown, Tex.). 2: 143-148. PMID 12695666  1
2003 Wang X, Zou L, Zheng H, Wei Q, Elledge SJ, Li L. Genomic instability and endoreduplication triggered by RAD17 deletion Genes and Development. 17: 965-970. PMID 12672690 DOI: 10.1101/gad.1065103  1
2003 Wang Y, Shirogane T, Liu D, Harper JW, Elledge SJ. Exit from exit: Resetting the cell cycle through Amn1 inhibition of G protein signaling Cell. 112: 697-709. PMID 12628189 DOI: 10.1016/S0092-8674(03)00121-1  1
2003 Stewart GS, Wang B, Bigneli CR, Taylor AMR, Elledge SJ. MDC1 is a mediator of the mammalian DNA damage checkpoint Nature. 421: 961-966. PMID 12607005 DOI: 10.1038/nature01446  1
2003 Morales JC, Xia Z, Lu T, Aldrich MB, Wang B, Rosales C, Kellems RE, Hittelman WN, Elledge SJ, Carpenter PB. Role for the BRCA1 C-terminal repeats (BRCT) protein 53BP1 in maintaining genomic stability. The Journal of Biological Chemistry. 278: 14971-7. PMID 12578828 DOI: 10.1074/jbc.M212484200  1
2002 Hu F, Elledge SJ. Bub2 is a cell cycle regulated phospho-protein controlled by multiple checkpoints Cell Cycle (Georgetown, Tex.). 1: 351-355. PMID 12461298  1
2002 Osborn AJ, Elledge SJ, Zou L. Checking on the fork: The DNA-replication stress-response pathway Trends in Cell Biology. 12: 509-516. PMID 12446112 DOI: 10.1016/S0962-8924(02)02380-2  1
2002 Wang B, Matsuoka S, Carpenter PB, Elledge SJ. 53BP1, a mediator of the DNA damage checkpoint Science. 298: 1435-1438. PMID 12364621 DOI: 10.1126/science.1076182  1
2002 Wilson JH, Elledge SJ. Cancer: BRCA2 enters the fray Science. 297: 1822-1823. PMID 12228708 DOI: 10.1126/science.1077171  1
2002 Hirao A, Cheung A, Duncan G, Girard PM, Elia AJ, Wakeham A, Okada H, Sarkissian T, Wong JA, Sakai T, De Stanchina E, Bristow RG, Suda T, Lowe SW, Jeggo PA, ... Elledge SJ, et al. Chk2 is a tumor suppressor that regulates apoptosis in both an ataxia telangiectasia mutated (ATM)-dependent and an ATM-independent manner. Molecular and Cellular Biology. 22: 6521-32. PMID 12192050 DOI: 10.1128/MCB.22.18.6521-6532.2002  1
2002 Stewart G, Elledge SJ. The two faces of BRCA2, a FANCtastic discovery Molecular Cell. 10: 2-4. PMID 12150898 DOI: 10.1016/S1097-2765(02)00580-4  1
2002 Elledge SJ, Amon A. The BRCA1 suppressor hypothesis: an explanation for the tissue-specific tumor development in BRCA1 patients. Cancer Cell. 1: 129-32. PMID 12086871 DOI: 10.1016/S1535-6108(02)00041-7  1
2002 Bachant J, Alcasabas A, Blat Y, Kleckner N, Elledge SJ. The SUMO-1 isopeptidase Smt4 is linked to centromeric cohesion through SUMO-1 modification of DNA topoisomerase II. Molecular Cell. 9: 1169-82. PMID 12086615 DOI: 10.1016/S1097-2765(02)00543-9  1
2002 Wang H, Elledge SJ. Genetic and physical interactions between DPB11 and DDC1 in the yeast DNA damage response pathway Genetics. 160: 1295-1304. PMID 11973288  1
2002 Zheng N, Schulman BA, Song L, Miller JJ, Jeffrey PD, Wang P, Chu C, Koepp DM, Elledge SJ, Pagano M, Conaway RC, Conaway JW, Harper JW, Pavletich NP. Structure of the Cul1-Rbx1-Skp1-F boxSkp2 SCF ubiquitin ligase complex Nature. 416: 703-709. PMID 11961546 DOI: 10.1038/416703a  1
2002 Zou L, Cortez D, Elledge SJ. Regulation of ATR substrate selection by Rad17-dependent loading of Rad9 complexes onto chromatin Genes and Development. 16: 198-208. PMID 11799063 DOI: 10.1101/gad.950302  1
2002 Li Y, Bachant J, Alcasabas AA, Wang Y, Qin J, Elledge SJ. The mitotic spindle is required for loading of the DASH complex onto the kinetochore Genes and Development. 16: 183-197. PMID 11799062 DOI: 10.1101/gad.959402  1
2002 Weiss RS, Matsuoka S, Elledge SJ, Leder P. Hus1 acts upstream of chk1 in a mammalian DNA damage response pathway. Current Biology : Cb. 12: 73-7. PMID 11790307 DOI: 10.1016/S0960-9822(01)00626-1  1
2002 Zhang P, Li MZ, Elledge SJ. Towards genetic genome projects: Genomic library screening and gene-targeting vector construction in a single step Nature Genetics. 30: 31-39. PMID 11753384 DOI: 10.1038/ng797  1
2001 Zou L, Elledge SJ. Sensing and signaling DNA damage: roles of Rad17 and Rad9 complexes in the cellular response to DNA damage Harvey Lectures. 97: 1-15. PMID 14562514  1
2001 Hu F, Wang Y, Liu D, Li Y, Qin J, Elledge SJ. Regulation of the Bub2/Bfa1 GAP complex by Cdc5 and cell cycle checkpoints Cell. 107: 655-665. PMID 11733064 DOI: 10.1016/S0092-8674(01)00580-3  1
2001 Cortez D, Guntuku S, Qin J, Elledge SJ. ATR and ATRIP: Partners in checkpoint signaling Science. 294: 1713-1716. PMID 11721054 DOI: 10.1126/science.1065521  1
2001 Alcasabas AA, Osborn AJ, Bachant J, Hu F, Werler PJ, Bousset K, Furuya K, Diffley JF, Carr AM, Elledge SJ. Mrc1 transduces signals of DNA replication stress to activate Rad53. Nature Cell Biology. 3: 958-65. PMID 11715016 DOI: 10.1038/ncb1101-958  1
2001 Gasch AP, Huang M, Metzner S, Botstein D, Elledge SJ, Brown PO. Genomic expression responses to DNA-damaging agents and the regulatory role of the yeast ATR homolog Mec1p. Molecular Biology of the Cell. 12: 2987-3003. PMID 11598186  1
2001 Koepp DM, Schaefer LK, Ye X, Keyomarsi K, Chu C, Harper JW, Elledge SJ. Phosphorylation-dependent ubiquitination of cyctin E by the SCFFbw7 ubiquitin ligase Science. 294: 173-177. PMID 11533444 DOI: 10.1126/science.1065203  1
2001 Matsuoka S, Nakagawa T, Masuda A, Haruki N, Elledge SJ, Takahashi T. Reduced expression and impaired kinase activity of a Chk2 mutant identified in human lung cancer Cancer Research. 61: 5362-5365. PMID 11454675  1
2001 Wang H, Liu D, Wang Y, Qin J, Elledge SJ. Pds1 phosphorylation in response to DNA damage is essential for its DNA damage checkpoint function Genes and Development. 15: 1361-1372. PMID 11390356 DOI: 10.1101/gad.893201  1
2001 Paull TT, Cortez D, Bowers B, Elledge SJ, Gellert M. Direct DNA binding by Brca1 Proceedings of the National Academy of Sciences of the United States of America. 98: 6086-6091. PMID 11353843 DOI: 10.1073/pnas.111125998  1
2001 Hu F, Alcasabas AA, Elledge SJ. Asf1 links Rad53 to control of chromatin assembly Genes and Development. 15: 1061-1066. PMID 11331602 DOI: 10.1101/gad.873201  1
2001 Cho RJ, Huang M, Campbell MJ, Dong H, Steinmetz L, Sapinoso L, Hampton G, Elledge SJ, Davis RW, Lockhart DJ. Transcriptional regulation and function during the human cell cycle. Nature Genetics. 27: 48-54. PMID 11137997 DOI: 10.1038/83751  1
2001 Goldberg AL, Elledge SJ, Wade Harper J. The Cellular Chamber of Doom Scientific American. 284: 56-61.  1
2000 Huang M, Elledge SJ. The FHA domain, a phosphoamino acid binding domain involved in the DNA damage response pathway Cold Spring Harbor Symposia On Quantitative Biology. 65: 413-421. PMID 12760057  1
2000 Tibbetts RS, Cortez D, Brumbaugh KM, Scully R, Livingston D, Elledge SJ, Abraham RT. Functional interactions between BRCA1 and the checkpoint kinase ATR during genotoxic stress Genes and Development. 14: 2989-3002. PMID 11114888 DOI: 10.1101/gad.851000  1
2000 Zhou BBS, Elledge SJ. The DNA damage response: Putting checkpoints in perspective Nature. 408: 433-439. PMID 11100718 DOI: 10.1038/35044005  1
2000 Schulman BA, Carrano AC, Jeffrey PD, Bowen Z, Kinnucan ERE, Finnin MS, Elledge SJ, Harper JW, Pagano M, Pavletich NP. Insights into SCF ubiquitin ligases from the structure of the Skp1-Skp2 complex Nature. 408: 381-386. PMID 11099048 DOI: 10.1038/35042620  1
2000 Wang Y, Hu F, Elledge SJ. The Bfa1/Bub2 GAP complex comprises a universal checkpoint required to prevent mitotic exit Current Biology. 10: 1379-1382. PMID 11084339 DOI: 10.1016/S0960-9822(00)00779-X  1
2000 Liu Q, Li MZ, Liu D, Elledge SJ. Rapid construction of recombinant DNA by the univector plasmid-fusion system Methods in Enzymology. 328: 530-549. PMID 11075365  1
2000 Matsuoka S, Rotman G, Ogawa A, Shiloh Y, Tamai K, Elledge SJ. Ataxia telangiectasia-mutated phosphorylates Chk2 in vivo and in vitro Proceedings of the National Academy of Sciences of the United States of America. 97: 10389-10394. PMID 10973490  1
2000 Cortez D, Elledge SJ. Conducting the mitotic symphony Nature. 406: 354-356. PMID 10935617  1
2000 Liu Q, Guntuku S, Cui XS, Matsuoka S, Cortez D, Tamai K, Luo G, Carattini-Rivera S, DeMayo F, Bradley A, Donehower LA, Elledge SJ. Chk1 is an essential kinase that is regulated by Atr and required for the G2/M DNA damage checkpoint Genes and Development. 14: 1448-1459. PMID 10859164  1
2000 Gripp KW, Wotton D, Edwards MC, Roessler E, Ades L, Meinecke P, Richieri-Costa A, Zackai EH, Massagué J, Muenke M, Elledge SJ. Mutations in TGIF cause holoprosencephaly and link NODAL signalling to human neural axis determination Nature Genetics. 25: 205-208. PMID 10835638 DOI: 10.1038/76074  1
2000 Wang Y, Cortez D, Yazdi P, Neff N, Elledge SJ, Qin J. BASC, a super complex of BRCA1-associated proteins involved in the recognition and repair of aberrant DNA structures Genes and Development. 14: 927-939. PMID 10783165  1
2000 Lozano G, Elledge SJ. p53 Sends nucleotides to repair DNA Nature. 404: 24-25. PMID 10716425 DOI: 10.1038/35003670  1
1999 Caspary T, Cleary MA, Perlman EJ, Zhang P, Elledge SJ, Tilghman SM. Oppositely imprinted genes p57(Kip2) and Igf2 interact in a mouse model for Beckwith-Wiedemann syndrome Genes and Development. 13: 3115-3124. PMID 10601037 DOI: 10.1101/gad.13.23.3115  1
1999 Harper JW, Elledge SJ. Skipping into the E2F1-destruction pathway Nature Cell Biology. 1: E5-7. PMID 10559870  1
1999 Sanchez Y, Bachant J, Wang H, Hu F, Liu D, Tetzlaff M, Elledge SJ. Control of the DNA damage checkpoint by Chk1 and Rad53 protein kinases through distinct mechanisms Science. 286: 1166-1171. PMID 10550056 DOI: 10.1126/science.286.5442.1166  1
1999 Cortez D, Wang Y, Qin J, Elledge SJ. Requirement of ATM-dependent phosphorylation of Brca1 in the DNA damage response to double-strand breaks Science. 286: 1162-1166. PMID 10550055 DOI: 10.1126/science.286.5442.1162  1
1999 Winston JT, Koepp DM, Cihui Z, Elledge SJ, Harper JW. A family of mammalian F-box proteins Current Biology. 9: 1180-1182. PMID 10531037 DOI: 10.1016/S0960-9822(00)80021-4  1
1999 Ouspenski II, Elledge SJ, Brinkley BR. New yeast genes important for chromosome integrity and segregation identified by dosage effects on genome stability Nucleic Acids Research. 27: 3001-3008. PMID 10454593 DOI: 10.1093/nar/27.15.3001  1
1999 Kitagawa K, Skowyra D, Elledge SJ, Harper JW, Hieter P. SGT1 encodes an essential component of the yeast kinetochore assembly pathway and a novel subunit of the SCF ubiquitin ligase complex Molecular Cell. 4: 21-33. PMID 10445024 DOI: 10.1016/S1097-2765(00)80184-7  1
1999 Koepp DM, Harper JW, Elledge SJ. How the cyclin became a cyclin: Regulated proteolysis in the cell cycle Cell. 97: 431-434. PMID 10338207 DOI: 10.1016/S0092-8674(00)80753-9  1
1999 Bachant JB, Elledge SJ. Mitotic treasures in the nucleolus Nature. 398: 757-758. PMID 10235256 DOI: 10.1038/19641  1
1992 Ramer SW, Elledge SJ, Davis RW. Dominant genetics using a yeast genomic library under the control of a strong inducible promoter. Proceedings of the National Academy of Sciences of the United States of America. 89: 11589-93. PMID 1454852  0.96
1991 Elledge SJ, Mulligan JT, Ramer SW, Spottswood M, Davis RW. Lambda YES: a multifunctional cDNA expression vector for the isolation of genes by complementation of yeast and Escherichia coli mutations. Proceedings of the National Academy of Sciences of the United States of America. 88: 1731-5. PMID 1848010  0.96
1990 Elledge SJ, Davis RW. Two genes differentially regulated in the cell cycle and by DNA-damaging agents encode alternative regulatory subunits of ribonucleotide reductase. Genes & Development. 4: 740-51. PMID 2199320  0.96
1990 Jasin M, Elledge SJ, Davis RW, Berg P. Gene targeting at the human CD4 locus by epitope addition. Genes & Development. 4: 157-66. PMID 1692556  0.96
1989 Elledge SJ, Davis RW. Identification of the DNA damage-responsive element of RNR2 and evidence that four distinct cellular factors bind it. Molecular and Cellular Biology. 9: 5373-86. PMID 2685561  0.96
1989 Elledge SJ, Sugiono P, Guarente L, Davis RW. Genetic selection for genes encoding sequence-specific DNA-binding proteins. Proceedings of the National Academy of Sciences of the United States of America. 86: 3689-93. PMID 2657725  0.96
1989 Elledge SJ, Davis RW. Position and density effects on repression by stationary and mobile DNA-binding proteins. Genes & Development. 3: 185-97. PMID 2523839  0.96
1989 Elledge SJ, Davis RW. DNA damage induction of ribonucleotide reductase. Molecular and Cellular Biology. 9: 4932-40. PMID 2513480  0.96
1988 Elledge SJ, Davis RW. A family of versatile centromeric vectors designed for use in the sectoring-shuffle mutagenesis assay in Saccharomyces cerevisiae. Gene. 70: 303-12. PMID 3063604  0.96
1987 Elledge SJ, Davis RW. Identification and isolation of the gene encoding the small subunit of ribonucleotide reductase from Saccharomyces cerevisiae: DNA damage-inducible gene required for mitotic viability. Molecular and Cellular Biology. 7: 2783-93. PMID 3313004  0.96
1985 Perry KL, Elledge SJ, Mitchell BB, Marsh L, Walker GC. umuDC and mucAB operons whose products are required for UV light- and chemical-induced mutagenesis: UmuD, MucA, and LexA proteins share homology. Proceedings of the National Academy of Sciences of the United States of America. 82: 4331-5. PMID 2989816 DOI: 10.1073/pnas.82.13.4331  1
1985 Elledge SJ, Walker GC. Phasmid vectors for identification of genes by complementation of Escherichia coli mutants. Journal of Bacteriology. 162: 777-83. PMID 2985547  1
1985 Winans SC, Elledge SJ, Krueger JH, Walker GC. Site-directed insertion and deletion mutagenesis with cloned fragments in Escherichia coli. Journal of Bacteriology. 161: 1219-21. PMID 2982787  1
1983 Elledge SJ, Walker GC. The muc genes of pKM101 are induced by DNA damage. Journal of Bacteriology. 155: 1306-15. PMID 6350267  1
1983 Walker GC, Elledge SJ, Perry KL, Bagg A, Kenyon CJ. Regulation and function of cellular gene products involved in UV and chemical mutagenesis in E. coli. Basic Life Sciences. 23: 181-202. PMID 6340657  1
1983 Elledge SJ, Walker GC. Proteins required for ultraviolet light and chemical mutagenesis. Identification of the products of the umuC locus of Escherichia coli. Journal of Molecular Biology. 164: 175-92. PMID 6302271 DOI: 10.1016/0022-2836(83)90074-8  1
1983 Krueger JH, Elledge SJ, Walker GC. Isolation and characterization of Tn5 insertion mutations in the lexA gene of Escherichia coli. Journal of Bacteriology. 153: 1368-78. PMID 6298183  0.96
1982 Walker GC, Elledge SJ, Kenyon CJ, Krueger JH, Perry KL. Mutagenesis and other responses induced by DNA damage in Escherichia coli. Biochimie. 64: 607-10. PMID 6291635 DOI: 10.1016/S0300-9084(82)80097-7  1
1982 Walker GC, Kenyon CJ, Bagg A, Elledge SJ, Perry KL, Shanabruch WG. Regulation and functions of Escherichia coli genes induced by DNA damage. Basic Life Sciences. 20: 43-63. PMID 6287997  1
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