William F. DeGrado, Ph.D. - Publications

Affiliations: 
1996-2011 University of Pennsylvania, Philadelphia, PA, United States 
 2011- Pharmaceutical Chemistry University of California, San Francisco, San Francisco, CA 
Area:
Organic Chemistry, Chemical Biology, De Novo Protein Design
Website:
http://www.degradolab.org/index.php

430 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2021 Thomaston JL, Samways ML, Konstantinidi A, Ma C, Hu Y, Bruce Macdonald HE, Wang J, Essex JW, DeGrado WF, Kolocouris A. Rimantadine Binds to and Inhibits the Influenza A M2 Proton Channel without Enantiomeric Specificity. Biochemistry. PMID 34342217 DOI: 10.1021/acs.biochem.1c00437  0.307
2021 Scott AJ, Niitsu A, Kratochvil HT, Lang EJM, Sengel JT, Dawson WM, Mahendran KR, Mravic M, Thomson AR, Brady RL, Liu L, Mulholland AJ, Bayley H, DeGrado WF, Wallace MI, et al. Constructing ion channels from water-soluble α-helical barrels. Nature Chemistry. PMID 33972753 DOI: 10.1038/s41557-021-00688-0  0.3
2020 Boyce JH, Dang B, Ary B, Edmondson Q, Craik CS, DeGrado WF, Seiple IB. Platform to Discover Protease-Activated Antibiotics and Application to Siderophore-Antibiotic Conjugates. Journal of the American Chemical Society. PMID 33301681 DOI: 10.1021/jacs.0c06987  0.776
2020 Sundaram A, Chen C, Isik Reed N, Liu S, Ki Yeon S, McIntosh J, Tang YZ, Yang H, Adler M, Beresis R, Seiple IB, Sheppard D, DeGrado WF, Jo H. Dual antagonists of α5β1/ αvβ1 integrin for airway hyperresponsiveness. Bioorganic & Medicinal Chemistry Letters. 127578. PMID 33007395 DOI: 10.1016/j.bmcl.2020.127578  0.729
2020 Watkins LC, DeGrado WF, Voth GA. Influenza A M2 Inhibitor Binding Understood through Mechanisms of Excess Proton Stabilization and Channel Dynamics. Journal of the American Chemical Society. 142: 17425-17433. PMID 32933245 DOI: 10.1021/Jacs.0C06419  0.338
2020 Newberry RW, Arhar T, Costello J, Hartoularos GC, Maxwell AM, Naing ZZC, Pittman M, Reddy NR, Schwarz DMC, Wassarman DR, Wu TS, Barrero D, Caggiano C, Catching A, Cavazos TB, ... ... DeGrado WF, et al. Robust Sequence Determinants of α-Synuclein Toxicity in Yeast Implicate Membrane Binding. Acs Chemical Biology. PMID 32786289 DOI: 10.1021/Acschembio.0C00339  0.379
2020 Newberry RW, Leong JT, Chow ED, Kampmann M, DeGrado WF. Deep mutational scanning reveals the structural basis for α-synuclein activity. Nature Chemical Biology. PMID 32152544 DOI: 10.1038/S41589-020-0480-6  0.398
2020 Korendovych IV, DeGrado WF. protein design, a retrospective. Quarterly Reviews of Biophysics. 53: e3. PMID 32041676 DOI: 10.1017/S0033583519000131  0.71
2020 Thomaston JL, Konstantinidi A, Liu L, Lambrinidis G, Tan J, Caffrey M, Wang J, Degrado WF, Kolocouris A. X-ray crystal structures of the influenza M2 proton channel drug-resistant V27A mutant bound to a spiro-adamantyl amine inhibitor reveal the mechanism of adamantane resistance. Biochemistry. PMID 31894969 DOI: 10.2210/Pdb6Nv1/Pdb  0.428
2019 Park J, Selvaraj B, McShan AC, Boyken SE, Wei KY, Oberdorfer G, DeGrado W, Sgourakis NG, Cuneo MJ, Myles DA, Baker D. De novo design of a homo-trimeric amantadine-binding protein. Elife. 8. PMID 31854299 DOI: 10.7554/Elife.47839  0.412
2019 Del Cid JS, Isik Reed N, Molnar K, Liu S, Dang B, Jensen SA, DeGrado W, Handford PA, Sheppard D, Sundaram AB. A disease associated mutation in fibrillin-1 differentially regulates integrin mediated cell adhesion. The Journal of Biological Chemistry. PMID 31640988 DOI: 10.1074/Jbc.Ra119.011109  0.331
2019 Dregni AJ, Mandala VS, Wu H, Elkins MR, Wang HK, Hung I, DeGrado WF, Hong M. In vitro 0N4R tau fibrils contain a monomorphic β-sheet core enclosed by dynamically heterogeneous fuzzy coat segments. Proceedings of the National Academy of Sciences of the United States of America. PMID 31358628 DOI: 10.1073/Pnas.1906839116  0.335
2019 Watkins LC, Liang R, Swanson JMJ, DeGrado WF, Voth GA. Proton Induced Conformational and Hydration Dynamics in the Influenza A M2 Channel. Journal of the American Chemical Society. PMID 31264413 DOI: 10.1021/Jacs.9B05136  0.343
2019 Thomaston JL, Wu Y, Polizzi N, Liu L, Wang J, DeGrado WF. X-ray crystal structure of the influenza A M2 proton channel S31N mutant in two conformational states: an open and shut case. Journal of the American Chemical Society. PMID 31184871 DOI: 10.1021/Jacs.9B02196  0.443
2019 Litvinov RI, Mravic M, Zhu H, Weisel JW, DeGrado WF, Bennett JS. Unique transmembrane domain interactions differentially modulate integrin αvβ3 and αIIbβ3 function. Proceedings of the National Academy of Sciences of the United States of America. PMID 31160446 DOI: 10.1073/Pnas.1904867116  0.353
2019 Yang B, Wang N, Schnier PD, Zheng F, Zhu H, Polizzi NF, Ittuveetil A, Saikam V, DeGrado W, Wang Q, Wang PG, Wang L. Genetically Introducing Biochemically Reactive Amino Acids Dehydroalanine and Dehydrobutyrine in Proteins. Journal of the American Chemical Society. PMID 31038942 DOI: 10.1021/Jacs.9B02611  0.326
2019 Wu H, Saltzberg DJ, Kratochvil HT, Jo H, Sali A, DeGrado WF. Glutamine side chain 13C=18O as a non-perturbative IR probe of amyloid fibril hydration and assembly. Journal of the American Chemical Society. PMID 30998340 DOI: 10.1021/Jacs.9B00577  0.358
2019 Zhang K, Ahmed IA, Kratochvil HT, DeGrado WF, Gai F, Jo H. Synthesis and application of the blue fluorescent amino acid l-4-cyanotryptophan to assess peptide-membrane interactions. Chemical Communications (Cambridge, England). PMID 30957824 DOI: 10.1039/C9Cc01152H  0.533
2019 Dang B, Mravic M, Hu H, Schmidt N, Mensa B, DeGrado WF. SNAC-tag for sequence-specific chemical protein cleavage. Nature Methods. 16: 319-322. PMID 30923372 DOI: 10.1038/S41592-019-0357-3  0.363
2019 Mravic M, Thomaston JL, Tucker M, Solomon PE, Liu L, DeGrado WF. Packing of apolar side chains enables accurate design of highly stable membrane proteins. Science (New York, N.Y.). 363: 1418-1423. PMID 30923216 DOI: 10.1126/Science.Aav7541  0.427
2019 Acharyya A, Ge Y, Wu H, DeGrado WF, Voelz VA, Gai F. Exposing the Nucleation Site in α-Helix Folding: A Joint Experimental and Simulation Study. The Journal of Physical Chemistry. B. PMID 30694671 DOI: 10.1021/Acs.Jpcb.8B12220  0.401
2019 Park J, Selvaraj B, McShan AC, Boyken SE, Wei KY, Oberdorfer G, DeGrado W, Sgourakis NG, Cuneo MJ, Myles DA, Baker D. Author response: De novo design of a homo-trimeric amantadine-binding protein Elife. DOI: 10.7554/Elife.47839.Sa2  0.353
2019 Fong KPY, Ahmed IA, Mravic M, Jo H, DeGrado WF, Gai F, Bennett JS. Direct Visualization of Platelet Integrins Using ANTI-Transmembrane Domain Peptides Containing a BLUE Fluorescent Amino Acid Blood. 134: 2344-2344. DOI: 10.1182/Blood-2019-128363  0.332
2019 Thomaston J, Wu Y, Liu L, Wang J, DeGrado W. Structural basis of adamantane resistance in the influenza A M2 proton channel Acta Crystallographica Section A. 75. DOI: 10.1107/S2053273319094166  0.373
2018 Yang B, Wu H, Schnier PD, Liu Y, Liu J, Wang N, DeGrado WF, Wang L. Proximity-enhanced SuFEx chemical cross-linker for specific and multitargeting cross-linking mass spectrometry. Proceedings of the National Academy of Sciences of the United States of America. PMID 30322930 DOI: 10.1073/Pnas.1813574115  0.338
2018 Chino M, Zhang SQ, Pirro F, Leone L, Maglio O, Lombardi A, DeGrado WF. Spectroscopic and metal binding properties of a de novo metalloprotein binding a tetrazinc cluster. Biopolymers. e23339. PMID 30203532 DOI: 10.1002/Bip.23229  0.68
2018 Thomaston JL, Polizzi NF, Konstantinidi A, Wang J, Kolocouris A, DeGrado WF. Inhibitors of the M2 proton channel engage and disrupt transmembrane networks of hydrogen-bonded waters. Journal of the American Chemical Society. PMID 30165017 DOI: 10.1021/Jacs.8B06741  0.443
2018 Liu J, Cheng R, Wu H, Li S, Wang PG, DeGrado WF, Rozovsky S, Wang L. Building and Breaking Bonds via a Compact S-propargyl-cysteine to Chemically Control Enzymes and Modify Proteins. Angewandte Chemie (International Ed. in English). PMID 30118570 DOI: 10.1002/Anie.201806197  0.371
2018 Bokoch MP, Jo H, Valcourt JR, Srinivasan Y, Pan AC, Capponi S, Grabe M, Dror RO, Shaw DE, DeGrado WF, Coughlin SR. Entry from the lipid bilayer: a possible pathway for inhibition of a peptide G protein-coupled receptor by a lipophilic small molecule. Biochemistry. PMID 30102523 DOI: 10.1021/Acs.Biochem.8B00577  0.365
2018 Zhang SQ, Huang H, Yang J, Kratochvil HT, Lolicato M, Liu Y, Shu X, Liu L, DeGrado WF. Designed peptides that assemble into cross-α amyloid-like structures. Nature Chemical Biology. PMID 30061717 DOI: 10.1038/S41589-018-0105-5  0.695
2018 Mravic M, Hu H, Lu Z, Bennett JS, Sanders CR, Orr AW, DeGrado WF. De novo designed transmembrane peptides activating the α5β1 integrin. Protein Engineering, Design & Selection : Peds. PMID 29992271 DOI: 10.1093/Protein/Gzy014  0.422
2018 Kang ES, Kim YT, Ko YS, Kim NH, Cho G, Huh YH, Kim JH, Nam J, Thach TT, Youn D, Kim YD, Yun WS, DeGrado WF, Kim SY, Hammond PT, et al. Peptide-Programmable Nanoparticle Superstructures with Tailored Electrocatalytic Activity. Acs Nano. PMID 29842775 DOI: 10.1021/Acsnano.8B01146  0.381
2018 Bhate MP, Lemmin T, Kuenze G, Mensa B, Ganguly S, Peters J, Schmidt N, Pelton JG, Gross C, Meiler J, DeGrado WF. Structure and function of the transmembrane domain of NsaS, an antibiotic sensing histidine kinase in S. aureus. Journal of the American Chemical Society. PMID 29771498 DOI: 10.1021/Jacs.7B09670  0.393
2018 Wu H, Acharyya A, Wu Y, Liu L, Jo H, Gai F, DeGrado W. Design of a short thermally stable α-helix embedded in a macrocycle. Chembiochem : a European Journal of Chemical Biology. PMID 29417711 DOI: 10.1002/Cbic.201800026  0.486
2018 Nick M, Wu Y, Schmidt NW, Prusiner SB, Stöhr J, DeGrado WF. A long-lived aβ oligomer resistant to fibrillization. Biopolymers. PMID 29319162 DOI: 10.1002/Bip.23096  0.356
2018 Litvinov RI, Fong KPY, Kim OV, Molnar KI, Billings PC, Sternisha A, Wells JA, Weisel JW, DeGrado WF, Bennett JS. Active Calpain Promotes Fibrin Clot Contraction By Strengthening the Coupling of Fibrin-Bound αIIbβ3 to the Platelet Cytoskeleton Blood. 132: 1128-1128. DOI: 10.1182/Blood-2018-99-113063  0.35
2018 Zhang S, Liu L, Yang J, Lolicato M, Kratochvil H, Shu X, DeGrado WF. De Novo Design of Cross-α Amyloid-Like Fibrils with Cellular Activity Biophysical Journal. 114: 410a. DOI: 10.1016/J.Bpj.2017.11.2272  0.631
2017 Yang B, Tang S, Ma C, Li ST, Shao GC, Dang B, DeGrado WF, Dong MQ, Wang PG, Ding S, Wang L. Spontaneous and specific chemical cross-linking in live cells to capture and identify protein interactions. Nature Communications. 8: 2240. PMID 29269770 DOI: 10.1038/S41467-017-02409-Z  0.359
2017 Zhang SQ, Chino M, Liu L, Tang Y, Hu X, DeGrado WF, Lombardi A. De Novo Design of Tetranuclear Transition Metal Clusters Stabilized by Hydrogen-Bonded Networks in Helical Bundles. Journal of the American Chemical Society. PMID 29249157 DOI: 10.1021/Jacs.7B08261  0.676
2017 Polizzi NF, Wu Y, Lemmin T, Maxwell AM, Zhang SQ, Rawson J, Beratan DN, Therien MJ, DeGrado WF. De novo design of a hyperstable non-natural protein-ligand complex with sub-Å accuracy. Nature Chemistry. 9: 1157-1164. PMID 29168496 DOI: 10.1038/Nchem.2846  0.676
2017 Schnaider L, Brahmachari S, Schmidt NW, Mensa B, Shaham-Niv S, Bychenko D, Adler-Abramovich L, Shimon LJW, Kolusheva S, DeGrado WF, Gazit E. Self-assembling dipeptide antibacterial nanostructures with membrane disrupting activity. Nature Communications. 8: 1365. PMID 29118336 DOI: 10.1038/S41467-017-01447-X  0.343
2017 Dang B, Wu H, Mulligan VK, Mravic M, Wu Y, Lemmin T, Ford A, Silva DA, Baker D, DeGrado WF. De novo design of covalently constrained mesosize protein scaffolds with unique tertiary structures. Proceedings of the National Academy of Sciences of the United States of America. PMID 28973862 DOI: 10.1073/Pnas.1710695114  0.461
2017 Stöhr J, Wu H, Nick M, Wu Y, Bhate M, Condello C, Johnson N, Rodgers J, Lemmin T, Acharya S, Becker J, Robinson K, Kelly MJS, Gai F, Stubbs G, ... ... DeGrado WF, et al. A 31-residue peptide induces aggregation of tau's microtubule-binding region in cells. Nature Chemistry. 9: 874-881. PMID 28837163 DOI: 10.1038/Nchem.2754  0.394
2017 Joh NH, Grigoryan G, Wu Y, DeGrado WF. Design of self-assembling transmembrane helical bundles to elucidate principles required for membrane protein folding and ion transport. Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences. 372. PMID 28630154 DOI: 10.1098/Rstb.2016.0214  0.706
2017 Lee M, Wang T, Makhlynets OV, Wu Y, Polizzi NF, Wu H, Gosavi PM, Stöhr J, Korendovych IV, DeGrado WF, Hong M. Zinc-binding structure of a catalytic amyloid from solid-state NMR. Proceedings of the National Academy of Sciences of the United States of America. PMID 28566494 DOI: 10.1073/Pnas.1706179114  0.82
2017 Wang T, Jo H, DeGrado WF, Hong M. Water Distribution, Dynamics and Interactions with Alzheimer's β-Amyloid Fibrils Investigated by Solid-State NMR. Journal of the American Chemical Society. PMID 28406028 DOI: 10.1021/Jacs.7B02089  0.301
2017 Findeisen F, Campiglio M, Jo H, Abderemane-Ali F, Rumpf CH, Pope L, Rossen ND, Flucher BE, DeGrado WF, Minor DL. Stapled voltage-gated calcium channel (CaV) α-interaction domain (AID) peptides act as selective protein-protein interaction inhibitors of CaV function. Acs Chemical Neuroscience. PMID 28278376 DOI: 10.1021/Acschemneuro.6B00454  0.413
2017 Hu Y, Musharrafieh R, Ma C, Zhang J, Smee DF, DeGrado WF, Wang J. An M2-V27A channel blocker demonstrates potent in vitro and in vivo antiviral activities against amantadine-sensitive and -resistant influenza A viruses. Antiviral Research. PMID 28087313 DOI: 10.1016/J.Antiviral.2017.01.006  0.36
2017 Dang B, Wu H, Mulligan VK, Mravic M, Wu Y, Lemmin T, Ford A, Silva D, Baker D, DeGrado WF. De Novo Design of Novel Covalent Constrained Meso-size Peptide Scaffolds with Unique Tertiary Structures Journal of Back and Musculoskeletal Rehabilitation. DOI: 10.2210/Pdb5V2G/Pdb  0.408
2017 Lee M, Wang T, Makhlynets OV, Wu Y, Polizzi N, Wu H, Gosavi PM, Korendovych IV, DeGrado WF, Hong M. Zinc-Binding Structure of a Catalytic Amyloid from Solid-State NMR Spectroscopy Journal of Back and Musculoskeletal Rehabilitation. DOI: 10.13018/Bmr30227  0.792
2017 Mustata G, Wanunu M, Gregoryan G, Ho Kim Y, Zhang J, DeGrado WF. Designer Peptides Self-Assemble on Graphene to Create Remarkably Stable, Precisely Organized Substrates Biophysical Journal. 112: 156a. DOI: 10.1016/J.Bpj.2016.11.859  0.379
2017 Wilhelm MJ, Mensa B, Sharifian Gh. M, DeGrado WF, Dai H. Real-Time Characterization of an Antimicrobial Mechanism-of-Action with Nonlinear Optical Scattering Biophysical Journal. 112: 382a. DOI: 10.1016/J.Bpj.2016.11.2077  0.326
2016 Schmidt NW, Grigoryan G, DeGrado WF. The accommodation index measures the perturbation associated with insertions and deletions in coiled-coils. Application to understand signaling in histidine kinases. Protein Science : a Publication of the Protein Society. PMID 27977891 DOI: 10.1002/Pro.3095  0.713
2016 Markiewicz BN, Lemmin T, Zhang W, Ahmed IA, Jo H, Fiorin G, Troxler T, DeGrado WF, Gai F. Infrared and fluorescence assessment of the hydration status of the tryptophan gate in the influenza A M2 proton channel. Physical Chemistry Chemical Physics : Pccp. PMID 27725984 DOI: 10.1039/C6Cp03426H  0.317
2016 Elkins MR, Wang T, Nick M, Jo H, Lemmin T, Prusiner SB, DeGrado WF, Stoehr J, Hong M. Structural Polymorphism of Alzheimer's β-Amyloid Fibrils as Controlled by an E22 Switch: A Solid-State NMR Study. Journal of the American Chemical Society. PMID 27414264 DOI: 10.1021/Jacs.6B03715  0.35
2016 Mustata GM, Kim YH, Zhang J, DeGrado WF, Grigoryan G, Wanunu M. Graphene Symmetry Amplified by Designed Peptide Self-Assembly. Biophysical Journal. 110: 2507-2516. PMID 27276268 DOI: 10.1016/J.Bpj.2016.04.037  0.699
2016 To TL, Medzihradszky KF, Burlingame AL, DeGrado WF, Jo H, Shu X. Photoactivatable protein labeling by singlet oxygen mediated reactions. Bioorganic & Medicinal Chemistry Letters. PMID 27220724 DOI: 10.1016/J.Bmcl.2016.05.034  0.33
2016 Kim KH, Ko DK, Kim YT, Kim NH, Paul J, Zhang SQ, Murray CB, Acharya R, DeGrado WF, Kim YH, Grigoryan G. Protein-directed self-assembly of a fullerene crystal. Nature Communications. 7: 11429. PMID 27113637 DOI: 10.1038/Ncomms11429  0.775
2016 Fong KP, Zhu H, Span LM, Moore DT, Yoon K, Tamura R, Yin HH, DeGrado WF, Bennett JS. Directly Activating αIIbβ3 Initiates Outside-In Signaling by Causing αIIbβ3 Clustering. The Journal of Biological Chemistry. PMID 27056329 DOI: 10.1074/Jbc.M116.716613  0.344
2016 Li F, Ma C, DeGrado WF, Wang J. Discovery of highly potent inhibitors targeting the predominant drug-resistant S31N mutant of the influenza A virus M2 proton channel. Journal of Medicinal Chemistry. PMID 26771709 DOI: 10.1021/Acs.Jmedchem.5B01910  0.369
2015 Thomaston JL, Alfonso-Prieto M, Woldeyes RA, Fraser JS, Klein ML, Fiorin G, DeGrado WF. High-resolution structures of the M2 channel from influenza A virus reveal dynamic pathways for proton stabilization and transduction. Proceedings of the National Academy of Sciences of the United States of America. 112: 14260-5. PMID 26578770 DOI: 10.1073/Pnas.1518493112  0.334
2015 Snyder RA, Betzu J, Butch SE, Reig AJ, DeGrado WF, Solomon EI. Systematic Perturbations of Binuclear Non-heme Iron Sites: Structure and Dioxygen Reactivity of de Novo Due Ferri Proteins. Biochemistry. 54: 4637-51. PMID 26154739 DOI: 10.1021/Acs.Biochem.5B00324  0.3
2015 Snyder RA, Butch SE, Reig AJ, DeGrado WF, Solomon EI. Molecular level insight into the differential oxidase and oxygenase reactivities of de novo Due Ferri proteins. Journal of the American Chemical Society. PMID 26090726 DOI: 10.1021/Jacs.5B03524  0.312
2015 Reed NI, Jo H, Chen C, Tsujino K, Arnold TD, DeGrado WF, Sheppard D. The αvβ1 integrin plays a critical in vivo role in tissue fibrosis. Science Translational Medicine. 7: 288ra79. PMID 25995225 DOI: 10.1126/Scitranslmed.Aaa5094  0.302
2015 Bhate MP, Molnar KS, Goulian M, DeGrado WF. Signal Transduction in Histidine Kinases: Insights from New Structures. Structure (London, England : 1993). 23: 981-994. PMID 25982528 DOI: 10.1016/J.Str.2015.04.002  0.309
2015 Zhang SQ, Kulp DW, Schramm CA, Mravic M, Samish I, DeGrado WF. The membrane- and soluble-protein helix-helix interactome: similar geometry via different interactions. Structure (London, England : 1993). 23: 527-41. PMID 25703378 DOI: 10.1016/J.Str.2015.01.009  0.828
2015 Zhang Y, Bartz R, Grigoryan G, Bryant M, Aaronson J, Beck S, Innocent N, Klein L, Procopio W, Tucker T, Jadhav V, Tellers DM, DeGrado WF. Computational design and experimental characterization of peptides intended for pH-dependent membrane insertion and pore formation. Acs Chemical Biology. 10: 1082-93. PMID 25630033 DOI: 10.1021/Cb500759P  0.733
2015 Huang S, Green B, Thompson M, Chen R, Thomaston J, DeGrado WF, Howard KP. C-terminal juxtamembrane region of full-length M2 protein forms a membrane surface associated amphipathic helix. Protein Science : a Publication of the Protein Society. 24: 426-9. PMID 25545360 DOI: 10.1002/Pro.2631  0.388
2015 Gianti E, Carnevale V, DeGrado WF, Klein ML, Fiorin G. Hydrogen-bonded water molecules in the M2 channel of the influenza A virus guide the binding preferences of ammonium-based inhibitors. The Journal of Physical Chemistry. B. 119: 1173-83. PMID 25353315 DOI: 10.1021/Jp506807Y  0.346
2014 Joh NH, Wang T, Bhate MP, Acharya R, Wu Y, Grabe M, Hong M, Grigoryan G, DeGrado WF. De novo design of a transmembrane Zn²⁺-transporting four-helix bundle. Science (New York, N.Y.). 346: 1520-4. PMID 25525248 DOI: 10.1126/Science.1261172  0.718
2014 Wu Y, Canturk B, Jo H, Ma C, Gianti E, Klein ML, Pinto LH, Lamb RA, Fiorin G, Wang J, DeGrado WF. Flipping in the pore: discovery of dual inhibitors that bind in different orientations to the wild-type versus the amantadine-resistant S31N mutant of the influenza A virus M2 proton channel. Journal of the American Chemical Society. 136: 17987-95. PMID 25470189 DOI: 10.1021/Ja508461M  0.388
2014 Dong H, Fiorin G, DeGrado WF, Klein ML. Proton release from the histidine-tetrad in the M2 channel of the influenza A virus. The Journal of Physical Chemistry. B. 118: 12644-51. PMID 25317959 DOI: 10.1021/Jp5102225  0.324
2014 Seither KM, McMahon HA, Singh N, Wang H, Cushman-Nick M, Montalvo GL, DeGrado WF, Shorter J. Specific aromatic foldamers potently inhibit spontaneous and seeded Aβ42 and Aβ43 fibril assembly. The Biochemical Journal. 464: 85-98. PMID 25142005 DOI: 10.1042/Bj20131609  0.786
2014 Molnar KS, Bonomi M, Pellarin R, Clinthorne GD, Gonzalez G, Goldberg SD, Goulian M, Sali A, DeGrado WF. Cys-scanning disulfide crosslinking and bayesian modeling probe the transmembrane signaling mechanism of the histidine kinase, PhoQ. Structure (London, England : 1993). 22: 1239-51. PMID 25087511 DOI: 10.1016/J.Str.2014.04.019  0.789
2014 Gonzalez G, Hannigan B, DeGrado WF. A real-time all-atom structural search engine for proteins. Plos Computational Biology. 10: e1003750. PMID 25079944 DOI: 10.1371/Journal.Pcbi.1003750  0.793
2014 Korendovych IV, DeGrado WF. Catalytic efficiency of designed catalytic proteins. Current Opinion in Structural Biology. 27: 113-21. PMID 25048695 DOI: 10.1016/J.Sbi.2014.06.006  0.641
2014 Ghosh A, Wang J, Moroz YS, Korendovych IV, Zanni M, DeGrado WF, Gai F, Hochstrasser RM. 2D IR spectroscopy reveals the role of water in the binding of channel-blocking drugs to the influenza M2 channel. The Journal of Chemical Physics. 140: 235105. PMID 24952572 DOI: 10.1063/1.4881188  0.751
2014 Mensa B, Howell GL, Scott R, DeGrado WF. Comparative mechanistic studies of brilacidin, daptomycin, and the antimicrobial peptide LL16. Antimicrobial Agents and Chemotherapy. 58: 5136-45. PMID 24936592 DOI: 10.1128/Aac.02955-14  0.315
2014 Pavone V, Zhang SQ, Merlino A, Lombardi A, Wu Y, DeGrado WF. Crystal structure of an amphiphilic foldamer reveals a 48-mer assembly comprising a hollow truncated octahedron. Nature Communications. 5: 3581. PMID 24705140 DOI: 10.1038/Ncomms4581  0.666
2014 Rufo CM, Moroz YS, Moroz OV, Stöhr J, Smith TA, Hu X, DeGrado WF, Korendovych IV. Short peptides self-assemble to produce catalytic amyloids. Nature Chemistry. 6: 303-9. PMID 24651196 DOI: 10.1038/Nchem.1894  0.813
2014 Montalvo GL, Zhang Y, Young TM, Costanzo MJ, Freeman KB, Wang J, Clements DJ, Magavern E, Kavash RW, Scott RW, Liu D, Degrado WF. De novo design of self-assembling foldamers that inhibit heparin-protein interactions. Acs Chemical Biology. 9: 967-75. PMID 24491145 DOI: 10.1021/Cb500026X  0.802
2014 Polishchuk AL, Cristian L, Pinto LH, Lear JD, DeGrado WF. Mechanistic insights from functional characterization of an unnatural His37 mutant of the influenza A/M2 protein. Biochimica Et Biophysica Acta. 1838: 1082-7. PMID 24269540 DOI: 10.1016/J.Bbamem.2013.11.011  0.59
2014 Montalvo GL, Gai F, Roder H, DeGrado WF. Slow folding-unfolding kinetics of an octameric β-peptide bundle. Acs Chemical Biology. 9: 276-81. PMID 24164344 DOI: 10.1021/Cb400621Y  0.818
2014 Molnar KS, Goldberg SD, Sali A, Goulian M, Bonomi M, DeGrado WF, Clinthorne GD, Gonzalez G, Pellarin R. Multi-state modeling of the PhoQ two-component system Structure. 22: 1239-1251. DOI: 10.5281/Zenodo.46600  0.756
2014 Wang T, Joh N, Wu Y, DeGrado W, Hong M. ssNMR structure of a designed rocker protein Journal of Back and Musculoskeletal Rehabilitation. DOI: 10.2210/Pdb2Muz/Pdb  0.388
2014 Span L, Nygren P, Wu Y, Zhu H, Moore DT, Cheng H, Roder H, DeGrado WF, Bennett JS. Integrin αIIbβ3-Mediated c-Src Activation: Differential Binding to Inactive and Active c-Src Blood. 124: 4158-4158. DOI: 10.1182/Blood.V124.21.4158.4158  0.335
2014 Campiglio M, Findeisen F, Jo H, DeGrado WF, Minor DL, Flucher BE. Differential Stability of CaVβ2a and CaVβ3 in a CaV1.2 Calcium Channel Complex Biophysical Journal. 106: 136a. DOI: 10.1016/J.Bpj.2013.11.797  0.357
2014 Zhang S, Jiang J, Ulas G, Wu Y, Tong W, DeGrado WF. Deciphering Regulatory Mechanism of the Juxtamembrane Region in Thrombopoietin Receptor Activation Biophysical Journal. 106: 103a. DOI: 10.1016/J.Bpj.2013.11.639  0.635
2014 Wang J, Wu Y, DeGrado WF. Structure and Inhibition of the M2 Proton Channel from the Influenza a Virus Biophysical Journal. 106: 549a. DOI: 10.1016/J.Bpj.2013.11.3060  0.405
2013 Roxbury D, Zhang SQ, Mittal J, Degrado WF, Jagota A. Structural Stability and Binding Strength of a Designed Peptide-Carbon Nanotube Hybrid. The Journal of Physical Chemistry. C, Nanomaterials and Interfaces. 117: 26255-26261. PMID 24466357 DOI: 10.1021/Jp405618P  0.704
2013 Nanda V, Cristian L, Toptygin D, Brand L, Degrado WF. Nanosecond Dynamics of InfluenzaA/M2TM and an Amantadine Resistant Mutant Probed by Time-Dependent Red Shifts of a Native Tryptophan. Chemical Physics. 422. PMID 24273370 DOI: 10.1016/J.Chemphys.2012.12.018  0.676
2013 Rey-Carrizo M, Torres E, Ma C, Barniol-Xicota M, Wang J, Wu Y, Naesens L, DeGrado WF, Lamb RA, Pinto LH, Vázquez S. 3-Azatetracyclo[5.2.1.1(5,8).0(1,5)]undecane derivatives: from wild-type inhibitors of the M2 ion channel of influenza A virus to derivatives with potent activity against the V27A mutant. Journal of Medicinal Chemistry. 56: 9265-74. PMID 24237039 DOI: 10.1021/Jm401340P  0.362
2013 Markiewicz BN, Jo H, Culik RM, DeGrado WF, Gai F. Assessment of local friction in protein folding dynamics using a helix cross-linker. The Journal of Physical Chemistry. B. 117: 14688-96. PMID 24205975 DOI: 10.1021/Jp409334H  0.339
2013 Ma C, Fiorin G, Carnevale V, Wang J, Lamb RA, Klein ML, Wu Y, Pinto LH, DeGrado WF. Asp44 stabilizes the Trp41 gate of the M2 proton channel of influenza A virus. Structure (London, England : 1993). 21: 2033-41. PMID 24139991 DOI: 10.1016/J.Str.2013.08.029  0.41
2013 Dong H, Fiorin G, Degrado WF, Klein ML. Exploring Histidine Conformations in the M2 Channel Lumen of the Influenza A Virus at Neutral pH via Molecular Simulations. The Journal of Physical Chemistry Letters. 4: 3067-3071. PMID 24069512 DOI: 10.1021/Jz401672H  0.31
2013 Rudick JG, Laakso MM, Schloss AC, DeGrado WF. Template-constrained cyclic sulfopeptide HIV-1 entry inhibitors. Organic & Biomolecular Chemistry. 11: 7096-100. PMID 24065278 DOI: 10.1039/C3Ob41395K  0.673
2013 Schmidt NW, Mishra A, Wang J, DeGrado WF, Wong GC. Influenza virus A M2 protein generates negative Gaussian membrane curvature necessary for budding and scission. Journal of the American Chemical Society. 135: 13710-9. PMID 23962302 DOI: 10.1021/Ja400146Z  0.428
2013 Koerber JT, Thomsen ND, Hannigan BT, Degrado WF, Wells JA. Nature-inspired design of motif-specific antibody scaffolds. Nature Biotechnology. 31: 916-21. PMID 23955275 DOI: 10.1038/Nbt.2672  0.784
2013 Fry HC, Lehmann A, Sinks LE, Asselberghs I, Tronin A, Krishnan V, Blasie JK, Clays K, DeGrado WF, Saven JG, Therien MJ. Computational de novo design and characterization of a protein that selectively binds a highly hyperpolarizable abiological chromophore. Journal of the American Chemical Society. 135: 13914-26. PMID 23931685 DOI: 10.1021/Ja4067404  0.642
2013 Williams JK, Tietze D, Wang J, Wu Y, DeGrado WF, Hong M. Drug-induced conformational and dynamical changes of the S31N mutant of the influenza M2 proton channel investigated by solid-state NMR. Journal of the American Chemical Society. 135: 9885-97. PMID 23758317 DOI: 10.1021/Ja4041412  0.454
2013 Wang J, Ma C, Wang J, Jo H, Canturk B, Fiorin G, Pinto LH, Lamb RA, Klein ML, DeGrado WF. Discovery of novel dual inhibitors of the wild-type and the most prevalent drug-resistant mutant, S31N, of the M2 proton channel from influenza A virus. Journal of Medicinal Chemistry. 56: 2804-12. PMID 23437766 DOI: 10.1021/Jm301538E  0.364
2013 Balgi AD, Wang J, Cheng DY, Ma C, Pfeifer TA, Shimizu Y, Anderson HJ, Pinto LH, Lamb RA, DeGrado WF, Roberge M. Inhibitors of the influenza A virus M2 proton channel discovered using a high-throughput yeast growth restoration assay. Plos One. 8: e55271. PMID 23383318 DOI: 10.1371/Journal.Pone.0055271  0.368
2013 Lemmin T, Soto CS, Clinthorne G, DeGrado WF, Dal Peraro M. Assembly of the transmembrane domain of E. coli PhoQ histidine kinase: implications for signal transduction from molecular simulations. Plos Computational Biology. 9: e1002878. PMID 23359663 DOI: 10.1371/Journal.Pcbi.1002878  0.802
2013 Mao L, Wang J, DeGrado WF, Inouye M. An assay suitable for high throughput screening of anti-influenza drugs. Plos One. 8: e54070. PMID 23326573 DOI: 10.1371/Journal.Pone.0054070  0.363
2013 Wang J, Wu Y, Ma C, Fiorin G, Wang J, Pinto LH, Lamb RA, Klein ML, Degrado WF. Structure and inhibition of the drug-resistant S31N mutant of the M2 ion channel of influenza A virus. Proceedings of the National Academy of Sciences of the United States of America. 110: 1315-20. PMID 23302696 DOI: 10.1073/Pnas.1216526110  0.419
2013 Thomaston JL, Nguyen PA, Brown EC, Upshur MA, Wang J, DeGrado WF, Howard KP. Detection of drug-induced conformational change of a transmembrane protein in lipid bilayers using site-directed spin labeling. Protein Science : a Publication of the Protein Society. 22: 65-73. PMID 23139077 DOI: 10.1002/Pro.2186  0.458
2013 Wu Y, Wang J, DeGrado W. Solution NMR structure of the influenza A virus S31N mutant (19-49) in presence of drug M2WJ332 Journal of Back and Musculoskeletal Rehabilitation. DOI: 10.2210/Pdb2Ly0/Pdb  0.372
2013 Zhu H, Moore DT, DeGrado WF, Bennett JS. Activating Individual αIIbβ3 Molecules Using An Anti-αIIb-Transmembrane Domain Peptide Causes αIIbβ3 Oligomerization and αIIbβ3-Mediated Outside-In Signaling Blood. 122: 3506-3506. DOI: 10.1182/Blood.V122.21.3506.3506  0.338
2012 Reig AJ, Pires MM, Snyder RA, Wu Y, Jo H, Kulp DW, Butch SE, Calhoun JR, Szyperski T, Szyperski TG, Solomon EI, DeGrado WF. Alteration of the oxygen-dependent reactivity of de novo Due Ferri proteins. Nature Chemistry. 4: 900-6. PMID 23089864 DOI: 10.1038/Nchem.1454  0.805
2012 Hong M, DeGrado WF. Structural basis for proton conduction and inhibition by the influenza M2 protein. Protein Science : a Publication of the Protein Society. 21: 1620-33. PMID 23001990 DOI: 10.1002/Pro.2158  0.376
2012 Jo H, Meinhardt N, Wu Y, Kulkarni S, Hu X, Low KE, Davies PL, DeGrado WF, Greenbaum DC. Development of α-helical calpain probes by mimicking a natural protein-protein interaction. Journal of the American Chemical Society. 134: 17704-13. PMID 22998171 DOI: 10.1021/Ja307599Z  0.45
2012 Schramm CA, Hannigan BT, Donald JE, Keasar C, Saven JG, Degrado WF, Samish I. Knowledge-based potential for positioning membrane-associated structures and assessing residue-specific energetic contributions. Structure (London, England : 1993). 20: 924-35. PMID 22579257 DOI: 10.1016/J.Str.2012.03.016  0.83
2012 Culik RM, Jo H, DeGrado WF, Gai F. Using thioamides to site-specifically interrogate the dynamics of hydrogen bond formation in β-sheet folding. Journal of the American Chemical Society. 134: 8026-9. PMID 22540162 DOI: 10.1021/Ja301681V  0.342
2012 Lanci CJ, MacDermaid CM, Kang SG, Acharya R, North B, Yang X, Qiu XJ, DeGrado WF, Saven JG. Computational design of a protein crystal. Proceedings of the National Academy of Sciences of the United States of America. 109: 7304-9. PMID 22538812 DOI: 10.1073/Pnas.1112595109  0.808
2012 Montero M, Gulzar N, Klaric KA, Donald JE, Lepik C, Wu S, Tsai S, Julien JP, Hessell AJ, Wang S, Lu S, Burton DR, Pai EF, Degrado WF, Scott JK. Neutralizing epitopes in the membrane-proximal external region of HIV-1 gp41 are influenced by the transmembrane domain and the plasma membrane. Journal of Virology. 86: 2930-41. PMID 22238313 DOI: 10.1128/Jvi.06349-11  0.342
2012 Moore DT, Nygren P, Jo H, Boesze-Battaglia K, Bennett JS, DeGrado WF. Affinity of talin-1 for the β3-integrin cytosolic domain is modulated by its phospholipid bilayer environment. Proceedings of the National Academy of Sciences of the United States of America. 109: 793-8. PMID 22210111 DOI: 10.1073/Pnas.1117220108  0.337
2012 Nygren P, Span LM, Moore DT, Cheng H, Roder H, DeGrado WF, Bennett JS. Analysis of β3 Binding to the c-Src SH3 Domain Blood. 120: 383-383. DOI: 10.1182/Blood.V120.21.383.383  0.398
2012 Reig AJ, Pires MM, Snyder RA, Wu Y, Jo H, Kulp DW, Butch SE, Calhoun JR, Szyperski T, Solomon EI, DeGrado WF. Erratum: Alteration of the oxygen-dependent reactivity of de novo Due Ferri proteins Nature Chemistry. 4: 1050-1050. DOI: 10.1038/Nchem.1519  0.768
2012 Korendovych IV, Shandler SJ, Montalvo GL, Degrado WF. Erratum: Environment- and sequence-dependence of helical type in membrane-spanning peptides composed of β 3-amino acids (Organic Letters (3475)) Organic Letters. 14. DOI: 10.1021/Ol301388F  0.797
2012 Fiorin G, Carnevale V, Wang J, Ma C, Wang T, Hu F, Lamb R, Pinto L, Hong M, DeGrado W, Klein M. Mapping Water Density to Design New Blockers Against a Viral Proton Channel Biophysical Journal. 102: 682a. DOI: 10.1016/J.Bpj.2011.11.3708  0.406
2012 Joh NH, Grigoryan G, Hu Y, DeGrado WF. Testing the Structural Mechanism of Transmembrane Translocation using De-Novo Designed Soft-Metal Transporters with Inverted Dual Topology Biophysical Journal. 102: 231a. DOI: 10.1016/J.Bpj.2011.11.1269  0.697
2011 Kim YH, Donald JE, Grigoryan G, Leser GP, Fadeev AY, Lamb RA, DeGrado WF. Capture and imaging of a prehairpin fusion intermediate of the paramyxovirus PIV5. Proceedings of the National Academy of Sciences of the United States of America. 108: 20992-7. PMID 22178759 DOI: 10.1073/Pnas.1116034108  0.721
2011 Soto CS, Hannigan BT, DeGrado WF. A photon-free approach to transmembrane protein structure determination. Journal of Molecular Biology. 414: 596-610. PMID 22024595 DOI: 10.1016/J.Jmb.2011.10.016  0.812
2011 Mensa B, Kim YH, Choi S, Scott R, Caputo GA, DeGrado WF. Antibacterial mechanism of action of arylamide foldamers. Antimicrobial Agents and Chemotherapy. 55: 5043-53. PMID 21844313 DOI: 10.1128/Aac.05009-11  0.65
2011 Wang J, Ma C, Wu Y, Lamb RA, Pinto LH, DeGrado WF. Exploring organosilane amines as potent inhibitors and structural probes of influenza a virus M2 proton channel. Journal of the American Chemical Society. 133: 13844-7. PMID 21819109 DOI: 10.1021/Ja2050666  0.408
2011 Shandler SJ, Korendovych IV, Moore DT, Smith-Dupont KB, Streu CN, Litvinov RI, Billings PC, Gai F, Bennett JS, DeGrado WF. Computational design of a β-peptide that targets transmembrane helices. Journal of the American Chemical Society. 133: 12378-81. PMID 21780757 DOI: 10.1021/Ja204215F  0.829
2011 Wang J, Ma C, Fiorin G, Carnevale V, Wang T, Hu F, Lamb RA, Pinto LH, Hong M, Klein ML, DeGrado WF. Molecular dynamics simulation directed rational design of inhibitors targeting drug-resistant mutants of influenza A virus M2. Journal of the American Chemical Society. 133: 12834-41. PMID 21744829 DOI: 10.1021/Ja204969M  0.394
2011 Wang J, Ma C, Balannik V, Pinto LH, Lamb RA, Degrado WF. Exploring the Requirements for the Hydrophobic Scaffold and Polar Amine in inhibitors of M2 from Influenza A Virus. Acs Medicinal Chemistry Letters. 2: 307-312. PMID 21691418 DOI: 10.1021/Ml100297W  0.378
2011 Korendovych IV, Shandler SJ, Montalvo GL, DeGrado WF. Environment- and sequence-dependence of helical type in membrane-spanning peptides composed of β3-amino acids. Organic Letters. 13: 3474-7. PMID 21651308 DOI: 10.1021/Ol201218Y  0.812
2011 Remorino A, Korendovych IV, Wu Y, DeGrado WF, Hochstrasser RM. Residue-specific vibrational echoes yield 3D structures of a transmembrane helix dimer. Science (New York, N.Y.). 332: 1206-9. PMID 21636774 DOI: 10.1126/Science.1202997  0.68
2011 Grigoryan G, Kim YH, Acharya R, Axelrod K, Jain RM, Willis L, Drndic M, Kikkawa JM, DeGrado WF. Computational design of virus-like protein assemblies on carbon nanotube surfaces. Science (New York, N.Y.). 332: 1071-6. PMID 21617073 DOI: 10.1126/Science.1198841  0.695
2011 Grigoryan G, Moore DT, DeGrado WF. Transmembrane communication: general principles and lessons from the structure and function of the M2 proton channel, K⁺ channels, and integrin receptors. Annual Review of Biochemistry. 80: 211-37. PMID 21548783 DOI: 10.1146/Annurev-Biochem-091008-152423  0.665
2011 Korendovych IV, Kulp DW, Wu Y, Cheng H, Roder H, DeGrado WF. Design of a switchable eliminase. Proceedings of the National Academy of Sciences of the United States of America. 108: 6823-7. PMID 21482808 DOI: 10.1073/Pnas.1018191108  0.791
2011 Duque MD, Ma C, Torres E, Wang J, Naesens L, Juárez-Jiménez J, Camps P, Luque FJ, DeGrado WF, Lamb RA, Pinto LH, Vázquez S. Exploring the size limit of templates for inhibitors of the M2 ion channel of influenza A virus. Journal of Medicinal Chemistry. 54: 2646-57. PMID 21466220 DOI: 10.1021/Jm101334Y  0.389
2011 Rogers JM, Polishchuk AL, Guo L, Wang J, DeGrado WF, Gai F. Photoinduced electron transfer and fluorophore motion as a probe of the conformational dynamics of membrane proteins: application to the influenza a M2 proton channel. Langmuir : the Acs Journal of Surfaces and Colloids. 27: 3815-21. PMID 21401044 DOI: 10.1021/La200480D  0.619
2011 Cady SD, Wang J, Wu Y, DeGrado WF, Hong M. Specific binding of adamantane drugs and direction of their polar amines in the pore of the influenza M2 transmembrane domain in lipid bilayers and dodecylphosphocholine micelles determined by NMR spectroscopy. Journal of the American Chemical Society. 133: 4274-84. PMID 21381693 DOI: 10.1021/Ja102581N  0.463
2011 Chakraborty S, Kravitz JY, Thulstrup PW, Hemmingsen L, DeGrado WF, Pecoraro VL. Design of a three-helix bundle capable of binding heavy metals in a triscysteine environment. Angewandte Chemie (International Ed. in English). 50: 2049-53. PMID 21344549 DOI: 10.1002/Anie.201006413  0.588
2011 Donald JE, Zhang Y, Fiorin G, Carnevale V, Slochower DR, Gai F, Klein ML, DeGrado WF. Transmembrane orientation and possible role of the fusogenic peptide from parainfluenza virus 5 (PIV5) in promoting fusion. Proceedings of the National Academy of Sciences of the United States of America. 108: 3958-63. PMID 21321234 DOI: 10.1073/Pnas.1019668108  0.521
2011 Donald JE, Kulp DW, DeGrado WF. Salt bridges: geometrically specific, designable interactions. Proteins. 79: 898-915. PMID 21287621 DOI: 10.1002/Prot.22927  0.723
2011 Wang J, Qiu JX, Soto C, DeGrado WF. Structural and dynamic mechanisms for the function and inhibition of the M2 proton channel from influenza A virus. Current Opinion in Structural Biology. 21: 68-80. PMID 21247754 DOI: 10.1016/J.Sbi.2010.12.002  0.41
2011 Fadeev AY, DeGrado WF. Lipid membranes supported on optically transparent nanosilicas: synthesis and application in characterization of protein-membrane interactions. Journal of Colloid and Interface Science. 355: 265-8. PMID 21193202 DOI: 10.1016/J.Jcis.2010.11.064  0.317
2011 Grigoryan G, Degrado WF. Probing designability via a generalized model of helical bundle geometry. Journal of Molecular Biology. 405: 1079-100. PMID 20932976 DOI: 10.1016/J.Jmb.2010.08.058  0.724
2011 Korendovych I, Kulp D, Wu Y, Cheng H, Roder H, DeGrado W. Calmodulin, C-terminal domain, F92E mutant Journal of Back and Musculoskeletal Rehabilitation. DOI: 10.2210/Pdb2Kz2/Pdb  0.745
2011 Pires M, Wu Y, Mills J, Reig A, Englander W, DeGrado W, Szyperski T. Solution structure of Diiron protein in presence of 8 eq Zn2+, Northeast Structural Genomics consortium target OR21 Journal of Back and Musculoskeletal Rehabilitation. DOI: 10.13018/Bmr17751  0.311
2011 Streu CN, Nygren P, Billings PC, Moore DT, Molnar KS, DeGrado WF, Bennett JS. Kindlin-3 Undergoes Endoproteolysis in Stored Platelets and After Platelet Stimulation Blood. 118: 1255-1255. DOI: 10.1182/Blood.V118.21.1255.1255  0.372
2011 Fiorin G, Donald JE, Zhang Y, Carnevale V, Slochower DR, Gai F, Klein ML, DeGrado WF. Association of Transmembrane Helices in Viral Fusion Peptides Suggests a Protein-Centric Mechanism of Membrane Fusion Biophysical Journal. 100: 633a. DOI: 10.1016/J.Bpj.2010.12.3637  0.538
2011 Chakraborty S, Yudenfreund Kravitz J, Thulstrup PW, Hemmingsen L, DeGrado WF, Pecoraro VL. Inside Cover: Design of a Three-Helix Bundle Capable of Binding Heavy Metals in a Triscysteine Environment (Angew. Chem. Int. Ed. 9/2011) Angewandte Chemie International Edition. 50: 1948-1948. DOI: 10.1002/Anie.201100297  0.517
2011 Chakraborty S, Yudenfreund Kravitz J, Thulstrup PW, Hemmingsen L, DeGrado WF, Pecoraro VL. Innentitelbild: Design of a Three-Helix Bundle Capable of Binding Heavy Metals in a Triscysteine Environment (Angew. Chem. 9/2011) Angewandte Chemie. 123: 1990-1990. DOI: 10.1002/Ange.201100297  0.517
2010 Carnevale V, Fiorin G, Levine BG, Degrado WF, Klein ML. Multiple Proton Confinement in the M2 Channel from the Influenza A Virus. The Journal of Physical Chemistry. C, Nanomaterials and Interfaces. 114: 20856-20863. PMID 21359105 DOI: 10.1021/Jp107431G  0.324
2010 Metcalf DG, Moore DT, Wu Y, Kielec JM, Molnar K, Valentine KG, Wand AJ, Bennett JS, DeGrado WF. NMR analysis of the alphaIIb beta3 cytoplasmic interaction suggests a mechanism for integrin regulation. Proceedings of the National Academy of Sciences of the United States of America. 107: 22481-6. PMID 21156831 DOI: 10.1073/Pnas.1015545107  0.784
2010 Jo H, Culik RM, Korendovych IV, Degrado WF, Gai F. Selective incorporation of nitrile-based infrared probes into proteins via cysteine alkylation. Biochemistry. 49: 10354-6. PMID 21077670 DOI: 10.1021/Bi101711A  0.677
2010 Polishchuk AL, Lear JD, Ma C, Lamb RA, Pinto LH, Degrado WF. A pH-dependent conformational ensemble mediates proton transport through the influenza A/M2 protein. Biochemistry. 49: 10061-71. PMID 20968306 DOI: 10.1021/Bi101229M  0.58
2010 Fiorin G, Carnevale V, DeGrado WF. Structural biology. The flu's proton escort. Science (New York, N.Y.). 330: 456-8. PMID 20966238 DOI: 10.1126/Science.1197748  0.311
2010 Korendovych IV, Senes A, Kim YH, Lear JD, Fry HC, Therien MJ, Blasie JK, Walker FA, Degrado WF. De novo design and molecular assembly of a transmembrane diporphyrin-binding protein complex. Journal of the American Chemical Society. 132: 15516-8. PMID 20945900 DOI: 10.1021/Ja107487B  0.818
2010 Korendovych IV, Kim YH, Ryan AH, Lear JD, Degrado WF, Shandler SJ. Computational design of a self-assembling β-peptide oligomer. Organic Letters. 12: 5142-5. PMID 20945888 DOI: 10.1021/Ol102092R  0.819
2010 Donald JE, Zhu H, Litvinov RI, DeGrado WF, Bennett JS. Identification of interacting hot spots in the beta3 integrin stalk using comprehensive interface design. The Journal of Biological Chemistry. 285: 38658-65. PMID 20929856 DOI: 10.1074/Jbc.M110.170670  0.331
2010 Lau WL, Degrado WF, Roder H. The effects of pK(a) tuning on the thermodynamics and kinetics of folding: design of a solvent-shielded carboxylate pair at the a-position of a coiled-coil. Biophysical Journal. 99: 2299-308. PMID 20923665 DOI: 10.1016/J.Bpj.2010.07.059  0.679
2010 Ivankin A, Livne L, Mor A, Caputo GA, Degrado WF, Meron M, Lin B, Gidalevitz D. Role of the conformational rigidity in the design of biomimetic antimicrobial compounds. Angewandte Chemie (International Ed. in English). 49: 8462-5. PMID 20872385 DOI: 10.1002/Anie.201003104  0.659
2010 Leiding T, Wang J, Martinsson J, DeGrado WF, Arsköld SP. Proton and cation transport activity of the M2 proton channel from influenza A virus. Proceedings of the National Academy of Sciences of the United States of America. 107: 15409-14. PMID 20713739 DOI: 10.1073/Pnas.1009997107  0.4
2010 Acharya R, Carnevale V, Fiorin G, Levine BG, Polishchuk AL, Balannik V, Samish I, Lamb RA, Pinto LH, DeGrado WF, Klein ML. Structure and mechanism of proton transport through the transmembrane tetrameric M2 protein bundle of the influenza A virus. Proceedings of the National Academy of Sciences of the United States of America. 107: 15075-80. PMID 20689043 DOI: 10.1073/Pnas.1007071107  0.597
2010 Zhu H, Metcalf DG, Streu CN, Billings PC, Degrado WF, Bennett JS. Specificity for homooligomer versus heterooligomer formation in integrin transmembrane helices. Journal of Molecular Biology. 401: 882-91. PMID 20615419 DOI: 10.1016/J.Jmb.2010.06.062  0.772
2010 Su Y, DeGrado WF, Hong M. Orientation, dynamics, and lipid interaction of an antimicrobial arylamide investigated by 19F and 31P solid-state NMR spectroscopy. Journal of the American Chemical Society. 132: 9197-205. PMID 20536141 DOI: 10.1021/Ja103658H  0.33
2010 Shandler SJ, Shapovalov MV, Dunbrack RL, DeGrado WF. Development of a rotamer library for use in beta-peptide foldamer computational design. Journal of the American Chemical Society. 132: 7312-20. PMID 20446685 DOI: 10.1021/Ja906700X  0.819
2010 Goldberg SD, Clinthorne GD, Goulian M, DeGrado WF. Transmembrane polar interactions are required for signaling in the Escherichia coli sensor kinase PhoQ. Proceedings of the National Academy of Sciences of the United States of America. 107: 8141-6. PMID 20404199 DOI: 10.1073/Pnas.1003166107  0.8
2010 Montalvo G, Waegele MM, Shandler S, Gai F, DeGrado WF. Infrared signature and folding dynamics of a helical beta-peptide. Journal of the American Chemical Society. 132: 5616-8. PMID 20373737 DOI: 10.1021/Ja100459A  0.81
2010 Fry HC, Lehmann A, Saven JG, DeGrado WF, Therien MJ. Computational design and elaboration of a de novo heterotetrameric alpha-helical protein that selectively binds an emissive abiological (porphinato)zinc chromophore. Journal of the American Chemical Society. 132: 3997-4005. PMID 20192195 DOI: 10.1021/Ja907407M  0.38
2010 Cady SD, Schmidt-Rohr K, Wang J, Soto CS, Degrado WF, Hong M. Structure of the amantadine binding site of influenza M2 proton channels in lipid bilayers. Nature. 463: 689-92. PMID 20130653 DOI: 10.1038/Nature08722  0.47
2010 Berger BW, Kulp DW, Span LM, DeGrado JL, Billings PC, Senes A, Bennett JS, DeGrado WF. Consensus motif for integrin transmembrane helix association. Proceedings of the National Academy of Sciences of the United States of America. 107: 703-8. PMID 20080739 DOI: 10.1073/Pnas.0910873107  0.812
2010 Balannik V, Carnevale V, Fiorin G, Levine BG, Lamb RA, Klein ML, Degrado WF, Pinto LH. Functional studies and modeling of pore-lining residue mutants of the influenza a virus M2 ion channel. Biochemistry. 49: 696-708. PMID 20028125 DOI: 10.1021/Bi901799K  0.329
2010 Balannik V, Obrdlik P, Inayat S, Steensen C, Wang J, Rausch JM, DeGrado WF, Kelety B, Pinto LH. Solid-supported membrane technology for the investigation of the influenza A virus M2 channel activity. PflüGers Archiv : European Journal of Physiology. 459: 593-605. PMID 19946785 DOI: 10.1007/S00424-009-0760-1  0.381
2010 Tew GN, Scott RW, Klein ML, Degrado WF. De novo design of antimicrobial polymers, foldamers, and small molecules: from discovery to practical applications. Accounts of Chemical Research. 43: 30-9. PMID 19813703 DOI: 10.1021/Ar900036B  0.617
2010 Cady S, Schmidt-Rohr K, Wang J, Soto C, DeGrado W, Hong M. Solid-state NMR structure of the M2 transmembrane peptide of the influenza A virus in DMPC lipid bilayers bound to deuterated amantadine Journal of Back and Musculoskeletal Rehabilitation. DOI: 10.2210/Pdb2Kqt/Pdb  0.451
2010 Streu CN, Moore DT, Billings PC, Nygren P, Fong KP, Metcalf DG, Wu Y, DeGrado WF, Bennett JS. Assessing the Biochemistry of Kindlin-3 In Human Platelets Blood. 116: 2011-2011. DOI: 10.1182/Blood.V116.21.2011.2011  0.771
2010 Ivankin A, Antipova A, Radzishevsky I, Mor A, Caputo GA, DeGrado WF, Gidalevitz D. Towards Design of Novel Antimicrobial Agents: Role of the Conformational Rigidity Biophysical Journal. 98: 85a. DOI: 10.1016/J.Bpj.2009.12.482  0.666
2010 Leiding T, Polishchuk A, DeGrado W, Hägerhäll C, Vinogradov S, Årsköld SP. Monitoring Proton Flux Quantitatively; Influenza Proton Channel A/M2 Biophysical Journal. 98: 224a. DOI: 10.1016/J.Bpj.2009.12.1212  0.583
2010 Cheng RP, Gellman SH, DeGrado WF. ChemInform Abstract: β-Peptides: From Structure to Function Cheminform. 32: no-no. DOI: 10.1002/chin.200152275  0.609
2010 DeGrado WF, Schneider JP, Hamuro Y. ChemInform Abstract: The Twists and Turns of β-Peptides Cheminform. 31: no-no. DOI: 10.1002/chin.200006298  0.498
2010 BETZ SF, BRYSON JW, PASSADOR MC, BROWN RJ, O'NEIL KT, DEGRADO WF. ChemInform Abstract: Expression of de novo Designed α-Helical Bundles Cheminform. 27: no-no. DOI: 10.1002/chin.199647296  0.637
2010 AKERFELDT KS, LEAR JD, WASSERMAN ZR, CHUNG LA, DEGRADO WF. ChemInform Abstract: Synthetic Peptides as Models for Ion Channel Proteins Cheminform. 24: no-no. DOI: 10.1002/chin.199332304  0.688
2009 Faiella M, Andreozzi C, de Rosales RT, Pavone V, Maglio O, Nastri F, DeGrado WF, Lombardi A. An artificial di-iron oxo-protein with phenol oxidase activity. Nature Chemical Biology. 5: 882-4. PMID 19915535 DOI: 10.1038/Nchembio.257  0.389
2009 Balannik V, Wang J, Ohigashi Y, Jing X, Magavern E, Lamb RA, Degrado WF, Pinto LH. Design and pharmacological characterization of inhibitors of amantadine-resistant mutants of the M2 ion channel of influenza A virus. Biochemistry. 48: 11872-82. PMID 19905033 DOI: 10.1021/Bi9014488  0.395
2009 Zhang Y, Kulp DW, Lear JD, DeGrado WF. Experimental and computational evaluation of forces directing the association of transmembrane helices. Journal of the American Chemical Society. 131: 11341-3. PMID 19722646 DOI: 10.1021/Ja904625B  0.699
2009 Kuhlman B, DeGrado WF. Engineering and design: editorial overview. Current Opinion in Structural Biology. 19: 440-1. PMID 19683427 DOI: 10.1016/J.Sbi.2009.07.010  0.499
2009 He F, Nair GR, Soto CS, Chang Y, Hsu L, Ronzone E, DeGrado WF, Binns AN. Molecular basis of ChvE function in sugar binding, sugar utilization, and virulence in Agrobacterium tumefaciens. Journal of Bacteriology. 191: 5802-13. PMID 19633083 DOI: 10.1128/Jb.00451-09  0.34
2009 Ma C, Polishchuk AL, Ohigashi Y, Stouffer AL, Schön A, Magavern E, Jing X, Lear JD, Freire E, Lamb RA, DeGrado WF, Pinto LH. Identification of the functional core of the influenza A virus A/M2 proton-selective ion channel. Proceedings of the National Academy of Sciences of the United States of America. 106: 12283-8. PMID 19590009 DOI: 10.1073/Pnas.0905726106  0.816
2009 Metcalf DG, Kulp DW, Bennett JS, DeGrado WF. Multiple approaches converge on the structure of the integrin alphaIIb/beta3 transmembrane heterodimer. Journal of Molecular Biology. 392: 1087-101. PMID 19527732 DOI: 10.1016/J.Jmb.2009.06.032  0.807
2009 Wang J, Cady SD, Balannik V, Pinto LH, DeGrado WF, Hong M. Discovery of spiro-piperidine inhibitors and their modulation of the dynamics of the M2 proton channel from influenza A virus. Journal of the American Chemical Society. 131: 8066-76. PMID 19469531 DOI: 10.1021/Ja900063S  0.439
2009 Choi S, Isaacs A, Clements D, Liu D, Kim H, Scott RW, Winkler JD, DeGrado WF. De novo design and in vivo activity of conformationally restrained antimicrobial arylamide foldamers. Proceedings of the National Academy of Sciences of the United States of America. 106: 6968-73. PMID 19359494 DOI: 10.1073/Pnas.0811818106  0.366
2009 Tang J, Yin H, Qiu J, Tucker MJ, DeGrado WF, Gai F. Using two fluorescent probes to dissect the binding, insertion, and dimerization kinetics of a model membrane peptide. Journal of the American Chemical Society. 131: 3816-7. PMID 19256494 DOI: 10.1021/Ja809007F  0.612
2009 Signarvic RS, Degrado WF. Metal-binding dependent disruption of membranes by designed helices. Journal of the American Chemical Society. 131: 3377-84. PMID 19209932 DOI: 10.1021/Ja809580B  0.817
2009 Khurana E, Dal Peraro M, DeVane R, Vemparala S, DeGrado WF, Klein ML. Molecular dynamics calculations suggest a conduction mechanism for the M2 proton channel from influenza A virus. Proceedings of the National Academy of Sciences of the United States of America. 106: 1069-74. PMID 19144924 DOI: 10.1073/Pnas.0811720106  0.346
2009 Miller MW, Basra S, Kulp DW, Billings PC, Choi S, Beavers MP, McCarty OJ, Zou Z, Kahn ML, Bennett JS, DeGrado WF. Small-molecule inhibitors of integrin alpha2beta1 that prevent pathological thrombus formation via an allosteric mechanism. Proceedings of the National Academy of Sciences of the United States of America. 106: 719-24. PMID 19141632 DOI: 10.1073/Pnas.0811622106  0.726
2009 Bissonnette ML, Donald JE, DeGrado WF, Jardetzky TS, Lamb RA. Functional analysis of the transmembrane domain in paramyxovirus F protein-mediated membrane fusion. Journal of Molecular Biology. 386: 14-36. PMID 19121325 DOI: 10.1016/J.Jmb.2008.12.029  0.375
2009 Bell CB, Calhoun JR, Bobyr E, Wei PP, Hedman B, Hodgson KO, Degrado WF, Solomon EI. Spectroscopic definition of the biferrous and biferric sites in de novo designed four-helix bundle DFsc peptides: implications for O2 reactivity of binuclear non-heme iron enzymes. Biochemistry. 48: 59-73. PMID 19090676 DOI: 10.1021/Bi8016087  0.78
2009 Kuroda K, Caputo GA, DeGrado WF. The role of hydrophobicity in the antimicrobial and hemolytic activities of polymethacrylate derivatives. Chemistry (Weinheim An Der Bergstrasse, Germany). 15: 1123-33. PMID 19072946 DOI: 10.1002/Chem.200801523  0.696
2009 Basani RB, Zhu H, Thornton MA, Soto CS, Degrado WF, Kowalska MA, Bennett JS, Poncz M. Species differences in small molecule binding to alpha IIb beta 3 are the result of sequence differences in 2 loops of the alpha IIb beta propeller. Blood. 113: 902-10. PMID 18987357 DOI: 10.1182/Blood-2008-09-177337  0.349
2009 Moore DT, Nygren P, Molnar K, Boesze-Battaglia K, Bennett JS, DeGrado WF. Protein-Protein and Protein-Lipid Interactions Modulate αIIbβ3 Inside-out Signaling. Blood. 114: 152-152. DOI: 10.1182/Blood.V114.22.152.152  0.374
2009 Balannik V, Steensen C, Obrdlik P, Kelety B, Wang J, DeGrado WF, Pinto LH. Reversibility of Amantadine Inhibition in the M2 Proton Channel of Influenza A Virus Biophysical Journal. 96: 668a. DOI: 10.1016/J.Bpj.2008.12.3531  0.393
2009 Ma C, Polishchuk A, Ohigashi Y, DeGrado WF, Lamb RA, Pinto LH. Determining the Functional Core for Proton Transport, Ion Selectivity and Amantadine Sensitivity of the A/M2 Protein from Influenza A Virus Biophysical Journal. 96: 668a. DOI: 10.1016/J.Bpj.2008.12.3529  0.599
2008 Weeks CL, Polishchuk A, Getahun Z, Degrado WF, Spiro TG. Investigation of an unnatural amino acid for use as a resonance Raman probe: Detection limits, solvent and temperature dependence of the νC≡N band of 4-cyanophenylalanine. Journal of Raman Spectroscopy : Jrs. 39: 1606-1613. PMID 20648227 DOI: 10.1002/Jrs.2067  0.573
2008 Scott RW, DeGrado WF, Tew GN. De novo designed synthetic mimics of antimicrobial peptides. Current Opinion in Biotechnology. 19: 620-7. PMID 18996193 DOI: 10.1016/J.Copbio.2008.10.013  0.594
2008 Nguyen PA, Soto CS, Polishchuk A, Caputo GA, Tatko CD, Ma C, Ohigashi Y, Pinto LH, DeGrado WF, Howard KP. pH-induced conformational change of the influenza M2 protein C-terminal domain. Biochemistry. 47: 9934-6. PMID 18754675 DOI: 10.1021/Bi801315M  0.741
2008 McAllister KA, Zou H, Cochran FV, Bender GM, Senes A, Fry HC, Nanda V, Keenan PA, Lear JD, Saven JG, Therien MJ, Blasie JK, DeGrado WF. Using alpha-helical coiled-coils to design nanostructured metalloporphyrin arrays. Journal of the American Chemical Society. 130: 11921-7. PMID 18710226 DOI: 10.1021/Ja800697G  0.807
2008 Caputo GA, Litvinov RI, Li W, Bennett JS, Degrado WF, Yin H. Computationally designed peptide inhibitors of protein-protein interactions in membranes. Biochemistry. 47: 8600-6. PMID 18642886 DOI: 10.1021/Bi800687H  0.768
2008 Shu JY, Tan C, DeGrado WF, Xu T. New design of helix bundle peptide-polymer conjugates. Biomacromolecules. 9: 2111-7. PMID 18627200 DOI: 10.1021/Bm800113G  0.791
2008 Stouffer AL, Ma C, Cristian L, Ohigashi Y, Lamb RA, Lear JD, Pinto LH, DeGrado WF. The interplay of functional tuning, drug resistance, and thermodynamic stability in the evolution of the M2 proton channel from the influenza A virus. Structure (London, England : 1993). 16: 1067-76. PMID 18611380 DOI: 10.1016/J.Str.2008.04.011  0.799
2008 Moore DT, Berger BW, DeGrado WF. Protein-protein interactions in the membrane: sequence, structural, and biological motifs. Structure (London, England : 1993). 16: 991-1001. PMID 18611372 DOI: 10.1016/J.Str.2008.05.007  0.693
2008 Calhoun JR, Bell CB, Smith TJ, Thamann TJ, DeGrado WF, Solomon EI. Oxygen reactivity of the biferrous site in the de novo designed four helix bundle peptide DFsc: nature of the "intermediate" and reaction mechanism. Journal of the American Chemical Society. 130: 9188-9. PMID 18572936 DOI: 10.1021/Ja801657Y  0.794
2008 Grigoryan G, Degrado WF. Modest membrane hydrogen bonds deliver rich results. Nature Chemical Biology. 4: 393-4. PMID 18560430 DOI: 10.1038/Nchembio0708-393  0.668
2008 Goldberg SD, Soto CS, Waldburger CD, Degrado WF. Determination of the physiological dimer interface of the PhoQ sensor domain. Journal of Molecular Biology. 379: 656-65. PMID 18468622 DOI: 10.1016/J.Jmb.2008.04.023  0.38
2008 Ma C, Soto CS, Ohigashi Y, Taylor A, Bournas V, Glawe B, Udo MK, Degrado WF, Lamb RA, Pinto LH. Identification of the pore-lining residues of the BM2 ion channel protein of influenza B virus. The Journal of Biological Chemistry. 283: 15921-31. PMID 18408016 DOI: 10.1074/Jbc.M710302200  0.369
2008 Calhoun JR, Liu W, Spiegel K, Dal Peraro M, Klein ML, Valentine KG, Wand AJ, DeGrado WF. Solution NMR structure of a designed metalloprotein and complementary molecular dynamics refinement. Structure (London, England : 1993). 16: 210-5. PMID 18275812 DOI: 10.1016/J.Str.2007.11.011  0.79
2008 Stouffer AL, Acharya R, Salom D, Levine AS, Di Costanzo L, Soto CS, Tereshko V, Nanda V, Stayrook S, DeGrado WF. Structural basis for the function and inhibition of an influenza virus proton channel. Nature. 451: 596-9. PMID 18235504 DOI: 10.1038/Nature06528  0.795
2008 Span LM, Grigoryan G, Bennett JS, DeGrado WF. Factors That Influence the Homo- and Hetero-Oligomerization of the Leukocyte Integrin Transmembrane Domains Blood. 112: 3556-3556. DOI: 10.1182/Blood.V112.11.3556.3556  0.712
2008 Metcalf DG, Kielec JM, Valentine KG, Wand AJ, DeGrado WF, Bennett JS. NMR Structure of a Disulfide-Crosslinked αIIbβ3 Cytoplasmic Domain Heterodimer Blood. 112: 2866-2866. DOI: 10.1182/Blood.V112.11.2866.2866  0.79
2008 Berger BW, Span LM, Kulp DW, Billings PC, DeGrado WF, Bennett JS. A Conserved Transmembrane Domain Interface Regulates Integrin Function Blood. 112: 2858-2858. DOI: 10.1182/Blood.V112.11.2858.2858  0.764
2008 Moore DdT, Ganjiwale A, Cheng H, Roder H, DeGrado WF, Bennett JS. Characterization of the Weak Interaction of C-Src with the β3 Cytoplasmic Tail Blood. 112: 2856-2856. DOI: 10.1182/Blood.V112.11.2856.2856  0.38
2008 Stouffer AL, Acharya R, Salom D, Levine AS, Di Costanzo L, Soto CS, Tereshko V, Nanda V, Stayrook S, DeGrado WF. Structural basis for the function and inhibition of an influenza virus proton channel (Nature (2008) 451, (596-599)) Nature. 452: 380. DOI: 10.1038/nature06845  0.776
2007 Tang J, Signarvic RS, DeGrado WF, Gai F. Role of helix nucleation in the kinetics of binding of mastoparan X to phospholipid bilayers. Biochemistry. 46: 13856-63. PMID 17994771 DOI: 10.1021/Bi7018404  0.823
2007 Mukherjee S, Chowdhury P, DeGrado WF, Gai F. Site-specific hydration status of an amphipathic peptide in AOT reverse micelles. Langmuir : the Acs Journal of Surfaces and Colloids. 23: 11174-9. PMID 17910485 DOI: 10.1021/La701686G  0.426
2007 Balakrishnan G, Hu Y, Bender GM, Getahun Z, DeGrado WF, Spiro TG. Enthalpic and entropic stages in alpha-helical peptide unfolding, from laser T-jump/UV Raman spectroscopy. Journal of the American Chemical Society. 129: 12801-8. PMID 17910449 DOI: 10.1021/Ja073366L  0.797
2007 Bender GM, Lehmann A, Zou H, Cheng H, Fry HC, Engel D, Therien MJ, Blasie JK, Roder H, Saven JG, DeGrado WF. De novo design of a single-chain diphenylporphyrin metalloprotein. Journal of the American Chemical Society. 129: 10732-40. PMID 17691729 DOI: 10.1021/Ja071199J  0.814
2007 Finikova OS, Troxler T, Senes A, DeGrado WF, Hochstrasser RM, Vinogradov SA. Energy and electron transfer in enhanced two-photon-absorbing systems with triplet cores. The Journal of Physical Chemistry. A. 111: 6977-90. PMID 17608457 DOI: 10.1021/Jp071586F  0.626
2007 White TC, Berny MA, Robinson DK, Yin H, DeGrado WF, Hanson SR, McCarty OJ. The leech product saratin is a potent inhibitor of platelet integrin alpha2beta1 and von Willebrand factor binding to collagen. The Febs Journal. 274: 1481-91. PMID 17489103 DOI: 10.1111/J.1742-4658.2007.05689.X  0.518
2007 Goodman CM, Choi S, Shandler S, DeGrado WF. Foldamers as versatile frameworks for the design and evolution of function. Nature Chemical Biology. 3: 252-62. PMID 17438550 DOI: 10.1038/Nchembio876  0.829
2007 Cady SD, Goodman C, Tatko CD, DeGrado WF, Hong M. Determining the orientation of uniaxially rotating membrane proteins using unoriented samples: a 2H, 13C, AND 15N solid-state NMR investigation of the dynamics and orientation of a transmembrane helical bundle. Journal of the American Chemical Society. 129: 5719-29. PMID 17417850 DOI: 10.1021/Ja070305E  0.399
2007 Yin H, Slusky JS, Berger BW, Walters RS, Vilaire G, Litvinov RI, Lear JD, Caputo GA, Bennett JS, DeGrado WF. Computational design of peptides that target transmembrane helices. Science (New York, N.Y.). 315: 1817-22. PMID 17395823 DOI: 10.1126/Science.1136782  0.822
2007 Metcalf DG, Law PB, DeGrado WF. Mutagenesis data in the automated prediction of transmembrane helix dimers. Proteins. 67: 375-84. PMID 17311347 DOI: 10.1002/Prot.21265  0.758
2007 Senes A, Chadi DC, Law PB, Walters RF, Nanda V, Degrado WF. E(z), a depth-dependent potential for assessing the energies of insertion of amino acid side-chains into membranes: derivation and applications to determining the orientation of transmembrane and interfacial helices. Journal of Molecular Biology. 366: 436-48. PMID 17174324 DOI: 10.1016/J.Jmb.2006.09.020  0.764
2007 Lee MH, Adams CS, Boettiger D, Degrado WF, Shapiro IM, Composto RJ, Ducheyne P. Adhesion of MC3T3-E1 cells to RGD peptides of different flanking residues: detachment strength and correlation with long-term cellular function. Journal of Biomedical Materials Research. Part A. 81: 150-60. PMID 17111408 DOI: 10.1002/Jbm.A.31065  0.375
2007 Zhu H, Metcalf DG, Li W, Gorelik R, Soto C, DeGrado WF, Bennett JS. Identification of Oligomerization Motifs in the β3 Transmembrane Domain. Blood. 110: 416-416. DOI: 10.1182/Blood.V110.11.416.416  0.772
2007 Metcalf DG, Kielec JM, Valentine KG, Joshua A, DeGrado WF, Bennett JS. Characterization of a Disulfide-Crosslinked αIIbβ3 Cytoplasmic Domain Heterodimer by NMR. Blood. 110: 415-415. DOI: 10.1182/Blood.V110.11.415.415  0.79
2007 Miller MW, Basra S, Billings PC, Gewirtz J, DeGrado WF, Bennett JS. The Design and Synthesis of Small Molecule Inhibitors of Collagen Binding to Integrin α2β1 as Antithrombotic Agents. Blood. 110: 306-306. DOI: 10.1182/Blood.V110.11.306.306  0.552
2007 White T, Berny M, Robinson D, Yin H, DeGrado W, Hanson S, McCarty O. THE LEECH PRODUCT SARATIN IS A POTENT INHIBITOR OF PLATELET INTEGRIN ALPHA2BETA1 AND VWF BINDING TO COLLAGEN Journal of Thrombosis and Haemostasis. 5: P-M-347-P-M-347. DOI: 10.1111/J.1538-7836.2007.Tb01268.X  0.44
2006 Fang C, Senes A, Cristian L, DeGrado WF, Hochstrasser RM. Amide vibrations are delocalized across the hydrophobic interface of a transmembrane helix dimer. Proceedings of the National Academy of Sciences of the United States of America. 103: 16740-5. PMID 17075037 DOI: 10.1073/Pnas.0608243103  0.675
2006 Yin H, Litvinov RI, Vilaire G, Zhu H, Li W, Caputo GA, Moore DT, Lear JD, Weisel JW, Degrado WF, Bennett JS. Activation of platelet alphaIIbbeta3 by an exogenous peptide corresponding to the transmembrane domain of alphaIIb. The Journal of Biological Chemistry. 281: 36732-41. PMID 17032655 DOI: 10.1074/Jbc.M605877200  0.749
2006 Bunagan MR, Cristian L, DeGrado WF, Gai F. Truncation of a cross-linked GCN4-p1 coiled coil leads to ultrafast folding. Biochemistry. 45: 10981-6. PMID 16953584 DOI: 10.1021/Bi0606142  0.376
2006 Wade H, Stayrook SE, Degrado WF. The structure of a designed diiron(III) protein: implications for cofactor stabilization and catalysis. Angewandte Chemie (International Ed. in English). 45: 4951-4. PMID 16819737 DOI: 10.1002/Anie.200600042  0.789
2006 North B, Cristian L, Fu Stowell X, Lear JD, Saven JG, Degrado WF. Characterization of a membrane protein folding motif, the Ser zipper, using designed peptides. Journal of Molecular Biology. 359: 930-9. PMID 16697010 DOI: 10.1016/J.Jmb.2006.04.001  0.843
2006 Yin H, Gerlach LO, Miller MW, Moore DT, Liu D, Vilaire G, Bennett JS, DeGrado WF. Arylamide derivatives as allosteric inhibitors of the integrin alpha2beta1/type I collagen interaction. Bioorganic & Medicinal Chemistry Letters. 16: 3380-2. PMID 16678410 DOI: 10.1016/J.Bmcl.2006.04.037  0.664
2006 Litvinov RI, Vilaire G, Li W, DeGrado WF, Weisel JW, Bennett JS. Activation of individual alphaIIbbeta3 integrin molecules by disruption of transmembrane domain interactions in the absence of clustering. Biochemistry. 45: 4957-64. PMID 16605263 DOI: 10.1021/Bi0526581  0.327
2006 Tatko CD, Nanda V, Lear JD, Degrado WF. Polar networks control oligomeric assembly in membranes. Journal of the American Chemical Society. 128: 4170-1. PMID 16568959 DOI: 10.1021/Ja055561A  0.597
2006 Ivanov I, Vemparala S, Pophristic V, Kuroda K, DeGrado WF, McCammon JA, Klein ML. Characterization of nonbiological antimicrobial polymers in aqueous solution and at water-lipid interfaces from all-atom molecular dynamics. Journal of the American Chemical Society. 128: 1778-9. PMID 16464062 DOI: 10.1021/Ja0564665  0.576
2006 Nanda V, DeGrado WF. Computational design of heterochiral peptides against a helical target. Journal of the American Chemical Society. 128: 809-16. PMID 16417370 DOI: 10.1021/Ja054452T  0.634
2006 Yin H, Frederick KK, Liu D, Wand AJ, Degrado WF. Arylamide derivatives as peptidomimetic inhibitors of calmodulin. Organic Letters. 8: 223-5. PMID 16408880 DOI: 10.1021/Ol052478J  0.602
2006 White TC, Robinson DK, Yin H, DeGrado WF, Hanson SR, McCarty OJT. The Leech Product Saratin Is a Potent Inhibitor of Both VWF and Integrin α2β1 Binding to Collagen. Blood. 108: 3928-3928. DOI: 10.1182/Blood.V108.11.3928.3928  0.518
2006 Berger BW, Gorelik R, DeGrado WF, Bennett JS. Factors Influencing the Homomeric and Heteromeric Association of Platelet Integrin Transmembrane Domains. Blood. 108: 212-212. DOI: 10.1182/Blood.V108.11.212.212  0.629
2006 Metcalf DG, DeGrado WF, Bennett JS. Computational Design of a Model for the Platelet Integrin αIIbβ3. Blood. 108: 1528-1528. DOI: 10.1182/Blood.V108.11.1528.1528  0.786
2006 Yin H, Slusky JS, Berger BW, Litvinov RI, Vilaire G, Lear JD, DeGrado WF, Bennett JS. Regulation of the Function of αvβ3 in Platelets by a Designed Peptide Targeting the αv Transmembrane Domain. Blood. 108: 1504-1504. DOI: 10.1182/Blood.V108.11.1504.1504  0.824
2006 Cochran FV, Wu SP, Wang W, Nanda V, Saven JG, Therien aMJ, DeGrado WF. Computational De Novo Design and Characterization of a Four-Helix Bundle Protein that Selectively Binds a Nonbiological Cofactor [J. Am. Chem. Soc. 2005, 127, 1346−1347]. Journal of the American Chemical Society. 128: 663-663. DOI: 10.1021/Ja059923Q  0.588
2006 Stouffer AL, DeGrado WF, Lear JD. Analytical ultracentrifugation studies of the influenza M2 homotetramerization equilibrium in detergent solutions Progress in Colloid and Polymer Science. 131: 108-115. DOI: 10.1007/2882_010  0.762
2005 Geremia S, Di Costanzo L, Randaccio L, Engel DE, Lombardi A, Nastri F, DeGrado WF. Response of a designed metalloprotein to changes in metal ion coordination, exogenous ligands, and active site volume determined by X-ray crystallography. Journal of the American Chemical Society. 127: 17266-76. PMID 16332076 DOI: 10.1021/Ja054199X  0.792
2005 Wei PP, Skulan AJ, Wade H, DeGrado WF, Solomon EI. Spectroscopic and computational studies of the de novo designed protein DF2t: correlation to the biferrous active site of ribonucleotide reductase and factors that affect O2 reactivity. Journal of the American Chemical Society. 127: 16098-106. PMID 16287296 DOI: 10.1021/Ja053661A  0.759
2005 Wang T, Lau WL, DeGrado WF, Gai F. T-jump infrared study of the folding mechanism of coiled-coil GCN4-p1. Biophysical Journal. 89: 4180-7. PMID 16150962 DOI: 10.1529/Biophysj.105.068809  0.634
2005 Summa CM, Levitt M, Degrado WF. An atomic environment potential for use in protein structure prediction. Journal of Molecular Biology. 352: 986-1001. PMID 16126228 DOI: 10.1016/J.Jmb.2005.07.054  0.768
2005 Engel DE, DeGrado WF. Alpha-alpha linking motifs and interhelical orientations. Proteins. 61: 325-37. PMID 16104016 DOI: 10.1002/Prot.20522  0.796
2005 Maglio O, Nastri F, Calhoun JR, Lahr S, Wade H, Pavone V, DeGrado WF, Lombardi A. Artificial di-iron proteins: solution characterization of four helix bundles containing two distinct types of inter-helical loops. Journal of Biological Inorganic Chemistry : Jbic : a Publication of the Society of Biological Inorganic Chemistry. 10: 539-49. PMID 16091937 DOI: 10.1007/S00775-005-0002-8  0.823
2005 Kovalenko OV, Metcalf DG, DeGrado WF, Hemler ME. Structural organization and interactions of transmembrane domains in tetraspanin proteins. Bmc Structural Biology. 5: 11. PMID 15985154 DOI: 10.1186/1472-6807-5-11  0.784
2005 Cristian L, Nanda V, Lear JD, DeGrado WF. Synergistic interactions between aqueous and membrane domains of a designed protein determine its fold and stability. Journal of Molecular Biology. 348: 1225-33. PMID 15854657 DOI: 10.1016/J.Jmb.2005.03.053  0.661
2005 Nanda V, Rosenblatt MM, Osyczka A, Kono H, Getahun Z, Dutton PL, Saven JG, Degrado WF. De novo design of a redox-active minimal rubredoxin mimic. Journal of the American Chemical Society. 127: 5804-5. PMID 15839675 DOI: 10.1021/Ja050553F  0.597
2005 Slovic AM, Stayrook SE, North B, Degrado WF. X-ray structure of a water-soluble analog of the membrane protein phospholamban: sequence determinants defining the topology of tetrameric and pentameric coiled coils. Journal of Molecular Biology. 348: 777-87. PMID 15826670 DOI: 10.1016/J.Jmb.2005.02.040  0.825
2005 Adamian L, Nanda V, DeGrado WF, Liang J. Empirical lipid propensities of amino acid residues in multispan alpha helical membrane proteins. Proteins. 59: 496-509. PMID 15789404 DOI: 10.1002/Prot.20456  0.609
2005 Slovic AM, Lear JD, DeGrado WF. De novo design of a pentameric coiled-coil: decoding the motif for tetramer versus pentamer formation in water-soluble phospholamban. The Journal of Peptide Research : Official Journal of the American Peptide Society. 65: 312-21. PMID 15787961 DOI: 10.1111/J.1399-3011.2005.00244.X  0.828
2005 Kuroda K, DeGrado WF. Amphiphilic polymethacrylate derivatives as antimicrobial agents. Journal of the American Chemical Society. 127: 4128-9. PMID 15783168 DOI: 10.1021/Ja044205+  0.487
2005 Nanda V, DeGrado WF. Automated use of mutagenesis data in structure prediction. Proteins. 59: 454-66. PMID 15768404 DOI: 10.1002/Prot.20382  0.604
2005 Duong-Ly KC, Nanda V, Degrado WF, Howard KP. The conformation of the pore region of the M2 proton channel depends on lipid bilayer environment. Protein Science : a Publication of the Protein Society. 14: 856-61. PMID 15741338 DOI: 10.1110/Ps.041185805  0.639
2005 Howard KP, Liu W, Crocker E, Nanda V, Lear J, Degrado WF, Smith SO. Rotational orientation of monomers within a designed homo-oligomer transmembrane helical bundle. Protein Science : a Publication of the Protein Society. 14: 1019-24. PMID 15741331 DOI: 10.1110/Ps.041110605  0.641
2005 Stouffer AL, Nanda V, Lear JD, DeGrado WF. Sequence determinants of a transmembrane proton channel: an inverse relationship between stability and function. Journal of Molecular Biology. 347: 169-79. PMID 15733926 DOI: 10.1016/J.Jmb.2005.01.023  0.81
2005 Lahr SJ, Engel DE, Stayrook SE, Maglio O, North B, Geremia S, Lombardi A, DeGrado WF. Analysis and design of turns in alpha-helical hairpins. Journal of Molecular Biology. 346: 1441-54. PMID 15713492 DOI: 10.1016/J.Jmb.2004.12.016  0.819
2005 Calhoun JR, Nastri F, Maglio O, Pavone V, Lombardi A, DeGrado WF. Artificial diiron proteins: from structure to function. Biopolymers. 80: 264-78. PMID 15700297 DOI: 10.1002/Bip.20230  0.8
2005 Cochran FV, Wu SP, Wang W, Nanda V, Saven JG, Therien MJ, DeGrado WF. Computational de novo design and characterization of a four-helix bundle protein that selectively binds a nonbiological cofactor. Journal of the American Chemical Society. 127: 1346-7. PMID 15686346 DOI: 10.1021/Ja044129A  0.636
2005 Li W, Metcalf DG, Gorelik R, Li R, Mitra N, Nanda V, Law PB, Lear JD, Degrado WF, Bennett JS. A push-pull mechanism for regulating integrin function. Proceedings of the National Academy of Sciences of the United States of America. 102: 1424-9. PMID 15671157 DOI: 10.1073/Pnas.0409334102  0.789
2005 Li R, Bennett JS, Degrado WF. Structural basis for integrin alphaIIbbeta3 clustering. Biochemical Society Transactions. 32: 412-5. PMID 15157149 DOI: 10.1042/Bst0320412  0.578
2005 Yin H, Zhu H, Vilaire G, Li W, Litvinov RI, DeGrado WF, Bennett JS. Activation of Platelet α Iibβ 3 by Exogenous Peptides Corresponding to the Transmembrane Domains of α Iib and β 3. Blood. 106: 384-384. DOI: 10.1182/Blood.V106.11.384.384  0.586
2005 Basani RB, Thornton MA, Sachais BS, Kowalska MA, Degrado WF, Bennett JS, Poncz M. Two Specific Domains on the Upper Surface of the αIib β Propeller Determine the Sensitivity of αIibβ3 for RGD-Containing Peptides. Blood. 106: 2653-2653. DOI: 10.1182/Blood.V106.11.2653.2653  0.393
2005 Choi S, Clements DJ, Pophristic V, Ivanov I, Vemparala S, Bennett JS, Klein ML, Winkler JD, DeGrado WF. Titelbild: The Design and Evaluation of Heparin-Binding Foldamers (Angew. Chem. 41/2005) Angewandte Chemie. 117: 6757-6757. DOI: 10.1002/Ange.200590136  0.3
2004 Wang T, Zhu Y, Getahun Z, Du D, Huang CY, Degrado WF, Gai F. Length Dependent Helix-Coil Transition Kinetics of Nine Alanine-Based Peptides. The Journal of Physical Chemistry. B. 108. PMID 24307864 DOI: 10.1021/Jp037272J  0.397
2004 Ghirlanda G, Hilcove SA, Pidikiti R, Johansson JS, Lear JD, Degrado WF, Eckenhoff RG. Volatile anesthetic modulation of oligomerization equilibria in a hexameric model peptide. Febs Letters. 578: 140-4. PMID 15581631 DOI: 10.1016/J.Febslet.2004.10.087  0.608
2004 Nanda V, Degrado WF. Simulated evolution of emergent chiral structures in polyalanine. Journal of the American Chemical Society. 126: 14459-67. PMID 15521766 DOI: 10.1021/Ja0461825  0.605
2004 Doerksen RJ, Chen B, Liu D, Tew GN, Degrado WF, Klein ML. Controlling the conformation of arylamides: computational studies of intramolecular hydrogen bonds between amides and ethers or thioethers. Chemistry (Weinheim An Der Bergstrasse, Germany). 10: 5008-16. PMID 15372664 DOI: 10.1002/Chem.200400176  0.523
2004 Lear JD, Stouffer AL, Gratkowski H, Nanda V, Degrado WF. Association of a model transmembrane peptide containing gly in a heptad sequence motif. Biophysical Journal. 87: 3421-9. PMID 15315956 DOI: 10.1529/Biophysj.103.032839  0.815
2004 Senes A, Engel DE, DeGrado WF. Folding of helical membrane proteins: the role of polar, GxxxG-like and proline motifs. Current Opinion in Structural Biology. 14: 465-79. PMID 15313242 DOI: 10.1016/J.Sbi.2004.07.007  0.82
2004 Kaplan J, DeGrado WF. De novo design of catalytic proteins. Proceedings of the National Academy of Sciences of the United States of America. 101: 11566-70. PMID 15292507 DOI: 10.1073/Pnas.0404387101  0.347
2004 Ghirlanda G, Osyczka A, Liu W, Antolovich M, Smith KM, Dutton PL, Wand AJ, DeGrado WF. De novo design of a D2-symmetrical protein that reproduces the diheme four-helix bundle in cytochrome bc1. Journal of the American Chemical Society. 126: 8141-7. PMID 15225055 DOI: 10.1021/Ja039935G  0.682
2004 Tucker MJ, Getahun Z, Nanda V, DeGrado WF, Gai F. A new method for determining the local environment and orientation of individual side chains of membrane-binding peptides. Journal of the American Chemical Society. 126: 5078-9. PMID 15099085 DOI: 10.1021/Ja032015D  0.622
2004 Li R, Gorelik R, Nanda V, Law PB, Lear JD, DeGrado WF, Bennett JS. Dimerization of the transmembrane domain of Integrin alphaIIb subunit in cell membranes. The Journal of Biological Chemistry. 279: 26666-73. PMID 15067009 DOI: 10.1074/Jbc.M314168200  0.686
2004 Engel DE, DeGrado WF. Amino acid propensities are position-dependent throughout the length of alpha-helices. Journal of Molecular Biology. 337: 1195-205. PMID 15046987 DOI: 10.1016/J.Jmb.2004.02.004  0.784
2004 Slovic AM, Kono H, Lear JD, Saven JG, DeGrado WF. Computational design of water-soluble analogues of the potassium channel KcsA. Proceedings of the National Academy of Sciences of the United States of America. 101: 1828-33. PMID 14766985 DOI: 10.1073/Pnas.0306417101  0.816
2004 Lau WL, Ege DS, Lear JD, Hammer DA, DeGrado WF. Oligomerization of fusogenic peptides promotes membrane fusion by enhancing membrane destabilization. Biophysical Journal. 86: 272-84. PMID 14695269 DOI: 10.1016/S0006-3495(04)74103-X  0.686
2004 Li W, Metcalf D, Gorelik R, Li R, Mitra N, Nanda V, Law PB, Lear JD, DeGrado WF, Bennett JS. Heteromeric and Homomeric Transmembrane Domain Associations Regulate αIIbβ3 Function. Blood. 104: 329-329. DOI: 10.1182/Blood.V104.11.329.329  0.798
2004 Tang J, Mei E, Green C, Kaplan J, Degrado WF, Smith AB, Hochstrasser RM. Probing structural dynamics of individual calmodulin:Peptide complexes in hydrogels by single-molecule confocal microscopy Journal of Physical Chemistry B. 108: 15910-15918. DOI: 10.1021/Jp0480798  0.333
2003 Zhu Y, Alonso DO, Maki K, Huang CY, Lahr SJ, Daggett V, Roder H, DeGrado WF, Gai F. Ultrafast folding of alpha3D: a de novo designed three-helix bundle protein. Proceedings of the National Academy of Sciences of the United States of America. 100: 15486-91. PMID 14671331 DOI: 10.1073/Pnas.2136623100  0.378
2003 Cristian L, Lear JD, DeGrado WF. Use of thiol-disulfide equilibria to measure the energetics of assembly of transmembrane helices in phospholipid bilayers. Proceedings of the National Academy of Sciences of the United States of America. 100: 14772-7. PMID 14657351 DOI: 10.1073/Pnas.2536751100  0.433
2003 Calhoun JR, Kono H, Lahr S, Wang W, DeGrado WF, Saven JG. Computational design and characterization of a monomeric helical dinuclear metalloprotein. Journal of Molecular Biology. 334: 1101-15. PMID 14643669 DOI: 10.1016/J.Jmb.2003.10.004  0.82
2003 Signarvic RS, DeGrado WF. De novo design of a molecular switch: phosphorylation-dependent association of designed peptides. Journal of Molecular Biology. 334: 1-12. PMID 14596795 DOI: 10.1016/J.Jmb.2003.09.041  0.819
2003 Cristian L, Lear JD, DeGrado WF. Determination of membrane protein stability via thermodynamic coupling of folding to thiol-disulfide interchange. Protein Science : a Publication of the Protein Society. 12: 1732-40. PMID 12876322 DOI: 10.1110/Ps.0378603  0.422
2003 Lear JD, Gratkowski H, Adamian L, Liang J, DeGrado WF. Position-dependence of stabilizing polar interactions of asparagine in transmembrane helical bundles. Biochemistry. 42: 6400-7. PMID 12767221 DOI: 10.1021/Bi020573J  0.834
2003 Li R, Mitra N, Gratkowski H, Vilaire G, Litvinov R, Nagasami C, Weisel JW, Lear JD, DeGrado WF, Bennett JS. Activation of integrin alphaIIbbeta3 by modulation of transmembrane helix associations. Science (New York, N.Y.). 300: 795-8. PMID 12730600 DOI: 10.1126/Science.1079441  0.794
2003 DeGrado WF, Gratkowski H, Lear JD. How do helix-helix interactions help determine the folds of membrane proteins? Perspectives from the study of homo-oligomeric helical bundles. Protein Science : a Publication of the Protein Society. 12: 647-65. PMID 12649422 DOI: 10.1110/Ps.0236503  0.833
2003 Li R, Hoess RH, Bennett JS, DeGrado WF. Use of phage display to probe the evolution of binding specificity and affinity in integrins. Protein Engineering. 16: 65-72. PMID 12646694 DOI: 10.1093/Proeng/Gzg002  0.567
2003 Walsh ST, Cheng RP, Wright WW, Alonso DO, Daggett V, Vanderkooi JM, DeGrado WF. The hydration of amides in helices; a comprehensive picture from molecular dynamics, IR, and NMR. Protein Science : a Publication of the Protein Society. 12: 520-31. PMID 12592022 DOI: 10.1110/Ps.0223003  0.738
2003 DeGrado WF, Di Costanzo L, Geremia S, Lombardi A, Pavone V, Randaccio L. Sliding helix and change of coordination geometry in a model di-MnII protein. Angewandte Chemie (International Ed. in English). 42: 417-20. PMID 12569505 DOI: 10.1002/Anie.200390127  0.321
2003 Slovic AM, Summa CM, Lear JD, DeGrado WF. Computational design of a water-soluble analog of phospholamban. Protein Science : a Publication of the Protein Society. 12: 337-48. PMID 12538897 DOI: 10.1110/Ps.0226603  0.813
2003 Papoian GA, DeGrado WF, Klein ML. Probing the configurational space of a metalloprotein core: an ab initio molecular dynamics study of Duo Ferro 1 binuclear Zn cofactor. Journal of the American Chemical Society. 125: 560-9. PMID 12517172 DOI: 10.1021/Ja028161L  0.333
2003 Bennett J, Li R, Vilaire G, Gratkowski H, Mitra N, Li W, Lear JD, DeGrado WF. Activation of the platelet integrin alphaIIbbeta3 by thermodynamic modulation of transmembrane helix associations Journal of Thrombosis and Haemostasis. 1: OC409-OC409. DOI: 10.1111/J.1538-7836.2003.Tb05896.X  0.44
2003 Magistrato A, DeGrado WF, Laio A, Rothlisberger U, VandeVondele J, Klein ML. Characterization of the Dizinc Analogue of the Synthetic Diiron Protein DF1 Using ab Initio and Hybrid Quantum/Classical Molecular Dynamics Simulations The Journal of Physical Chemistry B. 107: 4182-4188. DOI: 10.1021/Jp027032O  0.304
2003 Wade HV, Stayrook S, DeGrado WF. Structural analysis of a de novo designed metalloprotein Journal of Inorganic Biochemistry. 96: 246. DOI: 10.1016/S0162-0134(03)80798-5  0.771
2002 Li R, Babu CR, Valentine K, Lear JD, Wand AJ, Bennett JS, DeGrado WF. Characterization of the monomeric form of the transmembrane and cytoplasmic domains of the integrin beta 3 subunit by NMR spectroscopy. Biochemistry. 41: 15618-24. PMID 12501190 DOI: 10.1021/Bi026822L  0.593
2002 Huang CY, He S, DeGrado WF, McCafferty DG, Gai F. Light-induced helix formation. Journal of the American Chemical Society. 124: 12674-5. PMID 12392410 DOI: 10.1021/Ja028084U  0.341
2002 Cheng RP, DeGrado WF. Long-range interactions stabilize the fold of a non-natural oligomer. Journal of the American Chemical Society. 124: 11564-5. PMID 12296699 DOI: 10.1021/Ja020728A  0.663
2002 Summa CM, Rosenblatt MM, Hong JK, Lear JD, DeGrado WF. Computational de novo design, and characterization of an A(2)B(2) diiron protein. Journal of Molecular Biology. 321: 923-38. PMID 12206771 DOI: 10.1016/S0022-2836(02)00589-2  0.806
2002 Gratkowski H, Dai QH, Wand AJ, DeGrado WF, Lear JD. Cooperativity and specificity of association of a designed transmembrane peptide. Biophysical Journal. 83: 1613-9. PMID 12202385 DOI: 10.1016/S0006-3495(02)73930-1  0.823
2002 Howard KP, Lear JD, DeGrado WF. Sequence determinants of the energetics of folding of a transmembrane four-helix-bundle protein. Proceedings of the National Academy of Sciences of the United States of America. 99: 8568-72. PMID 12084917 DOI: 10.1073/Pnas.132266099  0.444
2002 Ghirlanda G, Lear JD, Ogihara NL, Eisenberg D, DeGrado WF. A hierarchic approach to the design of hexameric helical barrels. Journal of Molecular Biology. 319: 243-53. PMID 12051949 DOI: 10.1016/S0022-2836(02)00233-4  0.633
2002 Tew GN, Liu D, Chen B, Doerksen RJ, Kaplan J, Carroll PJ, Klein ML, DeGrado WF. De novo design of biomimetic antimicrobial polymers. Proceedings of the National Academy of Sciences of the United States of America. 99: 5110-4. PMID 11959961 DOI: 10.1073/Pnas.082046199  0.617
2002 Huang CY, Getahun Z, Zhu Y, Klemke JW, DeGrado WF, Gai F. Helix formation via conformation diffusion search. Proceedings of the National Academy of Sciences of the United States of America. 99: 2788-93. PMID 11867741 DOI: 10.1073/Pnas.052700099  0.359
2002 Di Costanzo L, Wade H, Geremia S, Randaccio L, Pavone V, DeGrado WF, Lombardi A. Toward the de novo design of a catalytically active helix bundle: a substrate-accessible carboxylate-bridged dinuclear metal center. Journal of the American Chemical Society. 123: 12749-57. PMID 11749531 DOI: 10.1021/Ja010506X  0.79
2002 Di Costanzo L, Geremia S, Randaccio L, DeGrado WF, Lombardi A, Pavone V. Phasing by maximal-minimal non-isomorphic sub-super-groups relationship in four-helix bundle designed protein Acta Crystallographica Section a Foundations of Crystallography. 58: c294-c294. DOI: 10.1107/S0108767302096733  0.308
2001 Tang Y, Ghirlanda G, Petka WA, Nakajima T, DeGrado WF, Tirrell DA. Fluorinated Coiled-Coil Proteins Prepared In Vivo Display Enhanced Thermal and Chemical Stability. Angewandte Chemie (International Ed. in English). 40: 1494-1496. PMID 29712367 DOI: 10.1002/1521-3773(20010417)40:8<1494::Aid-Anie1494>3.0.Co;2-X  0.584
2001 Cheng RP, Suich DJ, Cheng H, Roder H, DeGrado WF. Template-constrained somatostatin analogues: a biphenyl linker induces a type-V' turn. Journal of the American Chemical Society. 123: 12710-1. PMID 11741449 DOI: 10.1021/Ja0116932  0.572
2001 Huang CY, Getahun Z, Wang T, DeGrado WF, Gai F. Time-resolved infrared study of the helix-coil transition using (13)C-labeled helical peptides. Journal of the American Chemical Society. 123: 12111-2. PMID 11724630 DOI: 10.1021/Ja016631Q  0.347
2001 Cheng RP, Gellman SH, DeGrado WF. beta-Peptides: from structure to function. Chemical Reviews. 101: 3219-32. PMID 11710070 DOI: 10.1021/Cr000045I  0.64
2001 Walsh ST, Lee AL, DeGrado WF, Wand AJ. Dynamics of a de novo designed three-helix bundle protein studied by 15N, 13C, and 2H NMR relaxation methods. Biochemistry. 40: 9560-9. PMID 11583155 DOI: 10.1021/Bi0105274  0.611
2001 Huang CY, Klemke JW, Getahun Z, DeGrado WF, Gai F. Temperature-dependent helix-coil transition of an alanine based peptide. Journal of the American Chemical Society. 123: 9235-8. PMID 11562202 DOI: 10.1021/Ja0158814  0.334
2001 North B, Summa CM, Ghirlanda G, DeGrado WF. D(n)-symmetrical tertiary templates for the design of tubular proteins. Journal of Molecular Biology. 311: 1081-90. PMID 11531341 DOI: 10.1006/Jmbi.2001.4900  0.825
2001 Lear JD, Gratkowski H, DeGrado WF. De novo design, synthesis and characterization of membrane-active peptides Biochemical Society Transactions. 29: 559-564. PMID 11498028 DOI: 10.1042/Bst0290559  0.829
2001 Cheng RP, DeGrado WF. De novo design of a monomeric helical beta-peptide stabilized by electrostatic interactions. Journal of the American Chemical Society. 123: 5162-3. PMID 11457373 DOI: 10.1021/Ja010438E  0.662
2001 Tang Y, Ghirlanda G, Petka WA, Nakajima T, DeGrado WF, Tirrell DA. Fluorinated Coiled-Coil Proteins Prepared In Vivo Display Enhanced Thermal and Chemical Stability This work was supported by a grant from the U.S. Army Research Office. Y. Tang is supported by a Whitaker Graduate Research Fellowship. We thank Dr. Gary Hathaway for performing matrix-assisted laser desorption/ionization analyses. Angewandte Chemie (International Ed. in English). 40: 1494-1496. PMID 11317312 DOI: 10.1002/1521-3773(20010417)40:8<1494::AID-ANIE1494>3.0.CO;2-X  0.456
2001 Tang Y, Ghirlanda G, Vaidehi N, Kua J, Mainz DT, Goddard III WA, DeGrado WF, Tirrell DA. Stabilization of coiled-coil peptide domains by introduction of trifluoroleucine. Biochemistry. 40: 2790-6. PMID 11258889 DOI: 10.1021/Bi0022588  0.628
2001 Dalby PA, Hoess RH, DeGrado WF. Evolution of binding affinity in a WW domain probed by phage display. Protein Science : a Publication of the Protein Society. 9: 2366-76. PMID 11206058 DOI: 10.1110/Ps.9.12.2366  0.664
2001 Ogihara NL, Ghirlanda G, Bryson JW, Gingery M, DeGrado WF, Eisenberg D. Design of three-dimensional domain-swapped dimers and fibrous oligomers. Proceedings of the National Academy of Sciences of the United States of America. 98: 1404-9. PMID 11171963 DOI: 10.1073/Pnas.98.4.1404  0.587
2001 Gratkowski H, Lear JD, DeGrado WF. Polar side chains drive the association of model transmembrane peptides Proceedings of the National Academy of Sciences of the United States of America. 98: 880-885. PMID 11158564 DOI: 10.1073/Pnas.98.3.880  0.829
2001 Walsh ST, Sukharev VI, Betz SF, Vekshin NL, DeGrado WF. Hydrophobic core malleability of a de novo designed three-helix bundle protein. Journal of Molecular Biology. 305: 361-73. PMID 11124911 DOI: 10.1006/Jmbi.2000.4184  0.786
2001 Li R, Babu CR, Lear JD, Wand AJ, Bennett JS, DeGrado WF. Oligomerization of the integrin α∥bβ3: Roles of the transmembrane and cytoplasmic domains Proceedings of the National Academy of Sciences of the United States of America. 98: 12462-12467. DOI: 10.1073/Pnas.221463098  0.556
2001 Cheng RP, Gellman SH, DeGrado WF. β-peptides: From structure to function Chemical Reviews. 101: 3219-3232. DOI: 10.1021/cr000045i  0.633
2001 Hill RB, Raleigh DP, Lombardi A, Degrado WF. ChemInform Abstract: De novo Design of Helical Bundles as Models for Understanding Protein Folding and Function Cheminform. 32: no-no. DOI: 10.1002/chin.200106253  0.753
2000 Talaga DS, Lau WL, Roder H, Tang J, Jia Y, DeGrado WF, Hochstrasser RM. Dynamics and folding of single two-stranded coiled-coil peptides studied by fluorescent energy transfer confocal microscopy. Proceedings of the National Academy of Sciences of the United States of America. 97: 13021-6. PMID 11087856 DOI: 10.1073/Pnas.97.24.13021  0.657
2000 Salom D, Hill BR, Lear JD, DeGrado WF. pH-dependent tetramerization and amantadine binding of the transmembrane helix of M2 from the influenza A virus. Biochemistry. 39: 14160-70. PMID 11087364 DOI: 10.1021/Bi001799U  0.388
2000 Hill RB, Raleigh DP, Lombardi A, Degrado WF. De novo design of helical bundles as models for understanding protein folding and function Accounts of Chemical Research. 33: 745-754. PMID 11087311 DOI: 10.1021/Ar970004H  0.78
2000 Lombardi A, Summa CM, Geremia S, Randaccio L, Pavone V, DeGrado WF. Retrostructural analysis of metalloproteins: application to the design of a minimal model for diiron proteins. Proceedings of the National Academy of Sciences of the United States of America. 97: 6298-305. PMID 10841536 DOI: 10.1073/Pnas.97.12.6298  0.796
2000 Hill RB, DeGrado WF. A polar, solvent-exposed residue can be essential for native protein structure. Structure (London, England : 1993). 8: 471-9. PMID 10801493 DOI: 10.1016/S0969-2126(00)00130-1  0.727
2000 Choma C, Gratkowski H, Lear JD, DeGrado WF. Asparagine-mediated self-association of a model transmembrane helix. Nature Structural Biology. 7: 161-6. PMID 10655620 DOI: 10.1038/72440  0.826
2000 Hamm P, Lim M, DeGrado WF, Hochstrasser RM. Pump/probe self heterodyned 2D spectroscopy of vibrational transitions of a small globular peptide Journal of Chemical Physics. 112: 1907-1916. DOI: 10.1063/1.480772  0.345
2000 Hill RB, Hong JK, DeGrado WF. Hydrogen bonded cluster can specify the native state of a protein [18] Journal of the American Chemical Society. 122: 746-747. DOI: 10.1021/Ja9919332  0.659
2000 Hill RB, Bracken C, Degrado WF, Palmer AG. Molecular motions and protein folding: Characterization of the backbone dynamics and folding equilibrium of α2D using 13C NMR spin relaxation Journal of the American Chemical Society. 122: 11610-11619. DOI: 10.1021/Ja001129B  0.715
1999 DeGrado WF, Summa CM, Pavone V, Nastri F, Lombardi A. De novo design and structural characterization of proteins and metalloproteins. Annual Review of Biochemistry. 68: 779-819. PMID 10872466 DOI: 10.1146/Annurev.Biochem.68.1.779  0.791
1999 DeGrado WF, Schneider JP, Hamuro Y. The twists and turns of beta-peptides. The Journal of Peptide Research : Official Journal of the American Peptide Society. 54: 206-17. PMID 10517158 DOI: 10.1034/J.1399-3011.1999.00131.X  0.594
1999 Kochendoerfer GG, Salom D, Lear JD, Wilk-Orescan R, Kent SB, DeGrado WF. Total chemical synthesis of the integral membrane protein influenza A virus M2: role of its C-terminal domain in tetramer assembly. Biochemistry. 38: 11905-13. PMID 10508393 DOI: 10.1021/Bi990720M  0.463
1999 Summa CM, Lombardi A, Lewis M, DeGrado WF. Tertiary templates for the design of diiron proteins. Current Opinion in Structural Biology. 9: 500-8. PMID 10449377 DOI: 10.1016/S0959-440X(99)80071-2  0.789
1999 Patterson WR, Anderson DH, DeGrado WF, Cascio D, Eisenberg D. Centrosymmetric bilayers in the 0.75 A resolution structure of a designed alpha-helical peptide, D,L-Alpha-1. Protein Science : a Publication of the Protein Society. 8: 1410-22. PMID 10422829 DOI: 10.1110/Ps.8.7.1410  0.357
1999 Walsh ST, Cheng H, Bryson JW, Roder H, DeGrado WF. Solution structure and dynamics of a de novo designed three-helix bundle protein. Proceedings of the National Academy of Sciences of the United States of America. 96: 5486-91. PMID 10318910 DOI: 10.1073/Pnas.96.10.5486  0.668
1999 Hamm P, Lim M, DeGrado WF, Hochstrasser RM. The two-dimensional IR nonlinear spectroscopy of a cyclic penta-peptide in relation to its three-dimensional structure. Proceedings of the National Academy of Sciences of the United States of America. 96: 2036-41. PMID 10051590 DOI: 10.1073/Pnas.96.5.2036  0.354
1999 Gandhi CS, Shuck K, Lear JD, Dieckmann GR, DeGrado WF, Lamb RA, Pinto LH. Cu(II) inhibition of the proton translocation machinery of the influenza A virus M2 protein. The Journal of Biological Chemistry. 274: 5474-82. PMID 10026160 DOI: 10.1074/Jbc.274.9.5474  0.695
1999 Dieckmann GR, Lear JD, Zhong Q, Klein ML, DeGrado WF, Sharp KA. Exploration of the structural features defining the conduction properties of a synthetic ion channel Biophysical Journal. 76: 618-630. PMID 9929468 DOI: 10.1016/S0006-3495(99)77230-9  0.688
1999 Hamm P, Lim M, DeGrado WF, Hochstrasser RM. Stimulated photon echoes from amide I vibrations Journal of Physical Chemistry A. 103: 10049-10053. DOI: 10.1021/Jp9917650  0.304
1999 Hamuro Y, Schneider JP, DeGrado WF. De novo design of antibacterial β-peptides [9] Journal of the American Chemical Society. 121: 12200-12201. DOI: 10.1021/Ja992728P  0.573
1999 Summa CM, Lombardi A, Lewis M, DeGrado WF. Corrigendum: Tertiary templates for the design of diiron proteins (Current Opinion in Structural Biology (1999) 9 (500-508)) Current Opinion in Structural Biology. 9: 649. DOI: 10.1016/S0959-440X(99)00021-4  0.784
1999 Jia Y, Talaga DS, Lau WL, Lu HSM, DeGrado WF, Hochstrasser RM. Folding dynamics of single GCN-4 peptides by fluorescence resonant energy transfer confocal microscopy Chemical Physics. 247: 69-83. DOI: 10.1016/S0301-0104(99)00127-5  0.615
1998 Forrest LR, Degrado WF, Dieckmann GR, Sansom MSP. Two models of the influenza A M2 channel domain: Verification by comparison Folding and Design. 3: 443-448. PMID 9889158 DOI: 10.1016/S1359-0278(98)00061-3  0.718
1998 Ghirlanda G, Lear JD, Lombardi A, Degrado WF. From synthetic coiled coils to functional proteins: Automated design of a receptor for the calmodulin-binding domain of calcineurin Journal of Molecular Biology. 281: 379-391. PMID 9698554 DOI: 10.1006/Jmbi.1998.1912  0.552
1998 Dieckmann GR, McRorie DK, Lear JD, Sharp KA, DeGrado WF, Pecoraro VL. The role of protonation and metal chelation preferences in defining the properties of mercury-binding coiled coils. Journal of Molecular Biology. 280: 897-912. PMID 9671558 DOI: 10.1006/Jmbi.1998.1891  0.779
1998 Bryson JW, Desjarlais JR, Handel TM, DeGrado WF. From coiled coils to small globular proteins: design of a native-like three-helix bundle. Protein Science : a Publication of the Protein Society. 7: 1404-14. PMID 9655345 DOI: 10.1002/Pro.5560070617  0.67
1998 Schneider JP, Lombardi A, DeGrado WF. Analysis and design of three-stranded coiled coils and three-helix bundles. Folding & Design. 3: R29-40. PMID 9565750 DOI: 10.1016/S1359-0278(98)00011-X  0.584
1998 Hill RB, DeGrado WF. Solution Structure of α2D, a Nativelike de Novo Designed Protein Journal of the American Chemical Society. 120: 1138-1145. DOI: 10.1021/Ja9733649  0.47
1998 Schneider JP, DeGrado WF. The Design of Efficient α-Helical C-Capping Auxiliaries Journal of the American Chemical Society. 120: 2764-2767. DOI: 10.1021/Ja9726771  0.541
1997 Pinto LH, Dieckmann GR, Gandhi CS, Papworth CG, Braman J, Shaughnessy MA, Lear JD, Lamb RA, DeGrado WF. A functionally defined model for the M2 proton channel of influenza A virus suggests a mechanism for its ion selectivity. Proceedings of the National Academy of Sciences of the United States of America. 94: 11301-6. PMID 9326604 DOI: 10.1073/Pnas.94.21.11301  0.686
1997 Dieckmann GR, Degrado WF. Modeling transmembrane helical oligomers Current Opinion in Structural Biology. 7: 486-494. PMID 9266169 DOI: 10.1016/S0959-440X(97)80111-X  0.711
1997 Betz SF, Liebman PA, DeGrado WF. De novo design of native proteins: characterization of proteins intended to fold into antiparallel, rop-like, four-helix bundles. Biochemistry. 36: 2450-8. PMID 9054549 DOI: 10.1021/Bi961704H  0.759
1997 Volk M, Kholodenko Y, Lu HSM, Gooding EA, DeGrado WF, Hochstrasser RM. Peptide conformational dynamics and vibrational Stark effects following photoinitiated disulfide cleavage Journal of Physical Chemistry B. 101: 8607-8616. DOI: 10.1021/Jp971951A  0.379
1997 Lombardi A, Bryson JW, Ghirlanda G, DeGrado WF. Design of a Synthetic Receptor for the Calmodulin-Binding Domain of Calcineurin Journal of the American Chemical Society. 119: 12378-12379. DOI: 10.1021/Ja972973D  0.546
1997 Lu HSM, Volk M, Kholodenko Y, Gooding E, Hochstrasser RM, DeGrado WF. Aminothiotyrosine disulfide, an optical trigger for initiation of protein folding Journal of the American Chemical Society. 119: 7173-7180. DOI: 10.1021/Ja970567O  0.39
1997 Schneider JP, Lear JD, DeGrado WF. A Designed Buried Salt Bridge in a Heterodimeric Coiled Coil Journal of the American Chemical Society. 119: 5742-5743. DOI: 10.1021/Ja970493G  0.555
1997 Dieckmann GR, MoRorie DK, Tierney DL, Utschig LM, Singer CP, O'Halloran TV, Penner-Hahn JE, DeGrado WF, Pecoraro VL. De novo design of mercury-binding two- and three-helical bundles Journal of the American Chemical Society. 119: 6195-6196. DOI: 10.1021/Ja964351I  0.731
1997 Lear JD, Schneider JP, Kienker PK, DeGrado WF. Electrostatic effects on ion selectivity and rectification in designed ion channel peptides Journal of the American Chemical Society. 119: 3212-3217. DOI: 10.1021/Ja9629672  0.584
1996 Sosnick TR, Jackson S, Wilk RR, Englander SW, DeGrado WF. The role of helix formation in the folding of a fully alpha-helical coiled coil. Proteins. 24: 427-32. PMID 9162943 DOI: 10.1002/(Sici)1097-0134(199604)24:4<427::Aid-Prot2>3.0.Co;2-B  0.398
1996 Betz SF, Raleigh DP, DeGrado WF, Lovejoy B, Anderson D, Ogihara N, Eisenberg D. Crystallization of a designed peptide from a molten globule ensemble Folding and Design. 1: 57-64. PMID 9079364 DOI: 10.1016/S1359-0278(96)00012-0  0.79
1996 Lombardi A, Bryson JW, DeGrado WF. De novo design of heterotrimeric coiled coils. Biopolymers. 40: 495-504. PMID 9062072 DOI: 10.1002/(Sici)1097-0282(1996)40:5<495::Aid-Bip7>3.0.Co;2-R  0.491
1996 Boice JA, Dieckmann GR, DeGrado WF, Fairman R. Thermodynamic analysis of a designed three-stranded coiled coil Biochemistry. 35: 14480-14485. PMID 8931544 DOI: 10.1021/Bi961831D  0.81
1996 Betz SF, Bryson JW, Passador MC, Brown RJ, O'Neil KT, DeGrado WF. Expression of de novo designed alpha-helical bundles. Acta Chemica Scandinavica (Copenhagen, Denmark : 1989). 50: 688-96. PMID 8756357 DOI: 10.3891/Acta.Chem.Scand.50-0688  0.721
1996 DeGrado WF, Sosnick TR. Protein minimization: downsizing through mutation. Proceedings of the National Academy of Sciences of the United States of America. 93: 5680-1. PMID 8650151 DOI: 10.1073/Pnas.93.12.5680  0.498
1996 Betz SF, DeGrado WF. Controlling topology and native-like behavior of de novo-designed peptides: design and characterization of antiparallel four-stranded coiled coils. Biochemistry. 35: 6955-62. PMID 8639647 DOI: 10.1021/Bi960095A  0.767
1996 Ogihara NL, Weiss MS, DeGrado WF, Eisenberg D. The structure of a designed peptide refined to 2.1 Å resolution Acta Crystallographica Section a Foundations of Crystallography. 52: C215-C215. DOI: 10.1107/S0108767396090769  0.401
1996 Suich DJ, Ballinger MD, Wells JA, DeGrado WF. Fmoc-based synthesis of glycolate ester peptides for the assembly of de novo designed multimeric proteins using subtiligase Tetrahedron Letters. 37: 6653-6656. DOI: 10.1016/S0040-4039(96)01444-X  0.434
1996 Rabanal F, DeGrado WF, Dutton P. Use of 2,2′-dithiobis(5-nitropyridine) for the heterodimerization of cysteine containing peptides. Introduction of the 5-nitro-2-pyridinesulfenyl group Tetrahedron Letters. 37: 1347-1350. DOI: 10.1016/0040-4039(96)00019-6  0.384
1995 Betz SF, Bryson JW, DeGrado WF. Native-like and structurally characterized designed alpha-helical bundles. Current Opinion in Structural Biology. 5: 457-63. PMID 8528761 DOI: 10.1016/0959-440X(95)80029-8  0.699
1995 Betz S, Fairman R, O'Neil K, Lear J, Degrado W. Design of two-stranded and three-stranded coiled-coil peptides. Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences. 348: 81-8. PMID 7770490 DOI: 10.1098/Rstb.1995.0048  0.807
1995 Regan L, Rockwell A, Wasserman Z, DeGrado W. Disulfide crosslinks to probe the structure and flexibility of a designed four-helix bundle protein. Protein Science : a Publication of the Protein Society. 3: 2419-27. PMID 7756995 DOI: 10.1002/Pro.5560031225  0.609
1995 O'Neil KT, Hoess RH, Raleigh DP, DeGrado WF. Thermodynamic genetics of the folding of the B1 immunoglobulin-binding domain from streptococcal protein G Proteins: Structure, Function and Genetics. 21: 11-21. PMID 7716165 DOI: 10.1002/Prot.340210103  0.58
1995 Bryson JW, Betz SF, Lu HS, Suich DJ, Zhou HX, O'Neil KT, DeGrado WF. Protein design: a hierarchic approach. Science (New York, N.Y.). 270: 935-41. PMID 7481798 DOI: 10.1126/Science.270.5238.935  0.746
1995 Raleigh DP, Betz SF, DeGrado WF. A de novo designed protein mimics the native state of natural proteins Journal of the American Chemical Society. 117: 7558-7559. DOI: 10.1021/Ja00133A035  0.754
1994 Robertson DE, Farid RS, Moser CC, Urbauer JL, Mulholland SE, Pidikiti R, Lear JD, Wand AJ, DeGrado WF, Dutton PL. Design and synthesis of multi-haem proteins. Nature. 368: 425-32. PMID 8133888 DOI: 10.1038/368425A0  0.445
1994 Farid RS, Robertson DE, Moser CC, Pilloud D, DeGrado WF, Dutton PL. Design and synthesis of simplified energy-converting proteins. Biochemical Society Transactions. 22: 689-93. PMID 7821665 DOI: 10.1042/Bst0220689  0.392
1994 Kienker PK, DeGrado WF, Lear JD. A helical-dipole model describes the single-channel current rectification of an uncharged peptide ion channel. Proceedings of the National Academy of Sciences of the United States of America. 91: 4859-63. PMID 7515180 DOI: 10.1073/Pnas.91.11.4859  0.377
1994 Choma CT, Lear JD, Nelson MJ, Dutton PL, Robertson DE, DeGrado WF. Design of a heme-binding four-helix bundle Journal of the American Chemical Society. 116: 856-865. DOI: 10.1021/Ja00082A005  0.404
1994 Choma CT, Kaestle K, Åkerfeldt KS, Kim RM, Groves JT, DeGrado WF. A general method for coupling unprotected peptides to bromoacetamido porphyrin templates Tetrahedron Letters. 35: 6191-6194. DOI: 10.1016/S0040-4039(00)73388-0  0.71
1994 Åkerfeldt KS, DeGrado WF. Synthesis and per-functionalization of heptakis(6-O-carboxymethyl-2,3-di-O-methyl)cyclomaltoheptaose Tetrahedron Letters. 35: 4489-4492. DOI: 10.1016/S0040-4039(00)60708-6  0.653
1994 Sogah DY, Perle-Treves D, Voyer N, Degrado WF. Design and synthesis of polytripeptide (leuglnpro)n based upon the matrix protein amelogenin Macromolecular Symposia. 88: 149-163. DOI: 10.1002/Masy.19940880112  0.578
1993 Lovejoy B, Choe S, Cascio D, McRorie DK, DeGrado WF, Eisenberg D. Crystal structure of a synthetic triple-stranded alpha-helical bundle. Science (New York, N.Y.). 259: 1288-93. PMID 8446897 DOI: 10.1126/Science.8446897  0.403
1993 Handel TM, Williams SA, DeGrado WF. Metal ion-dependent modulation of the dynamics of a designed protein Science. 261: 879-885. PMID 8346440 DOI: 10.1126/Science.8346440  0.665
1993 Fairman R, Beran-Steed RK, Anthony-Cahill SJ, Lear JD, Stafford WF, DeGrado WF, Benfield PA, Brenner SL. Multiple oligomeric states regulate the DNA binding of helix-loop-helix peptides. Proceedings of the National Academy of Sciences of the United States of America. 90: 10429-33. PMID 8248126 DOI: 10.1073/Pnas.90.22.10429  0.816
1993 Lovejoy B, Akerfeldt KS, DeGrado WF, Eisenberg D. Crystallization of proton channel peptides. Protein Science : a Publication of the Protein Society. 1: 1073-7. PMID 1284681 DOI: 10.1002/Pro.5560010812  0.704
1993 Handel TM, Williams SA, Menyhard D, DeGrado WF. Introduction of a Trp residue into .alpha.4 as a probe of dynamics Journal of the American Chemical Society. 115: 4457-4460. DOI: 10.1021/Ja00064A006  0.644
1993 Akerfeldt KS, Lear JD, Wasserman ZR, Chung LA, DeGrado WF. Synthetic peptides as models for ion channel proteins Accounts of Chemical Research. 26: 191-197. DOI: 10.1021/Ar00028A009  0.711
1993 Betz SF, Raleigh DP, DeGrado WF. De novo protein design: from molten globules to native-like states. Current opinion in structural biology 1993, 3:601-610 Current Opinion in Structural Biology. 3: 601-610. DOI: 10.1016/0959-440X(93)90090-8  0.768
1993 Choma C, Åkerfeldt K, Dutton L, Lear J, Nelson M, Robertson D, DeGrado WF. Design of a heme-binding four-helix bundle Journal of Inorganic Biochemistry. 51: 58. DOI: 10.1016/0162-0134(93)85094-O  0.333
1992 Epand RM, Cheetham JJ, Epand RF, Yeagle PL, Richardson CD, Rockwell A, Degrado WF. Peptide models for the membrane destabilizing actions of viral fusion proteins. Biopolymers. 32: 309-14. PMID 1623124 DOI: 10.1002/Bip.360320403  0.42
1992 Rao U, Teeter MM, Erickson-Viitanen S, DeGrado WF. Calmodulin binding to alpha 1-purothionin: solution binding and modeling of the complex. Proteins. 14: 127-38. PMID 1409564 DOI: 10.1002/Prot.340140202  0.356
1992 Anthony-Cahill SJ, Benfield PA, Fairman R, Wasserman ZR, Brenner SL, Stafford WF, Altenbach C, Hubbell WL, DeGrado WF. Molecular characterization of helix-loop-helix peptides. Science (New York, N.Y.). 255: 979-83. PMID 1312255 DOI: 10.1126/Science.1312255  0.821
1992 Raleigh DP, DeGrado WF. A de novo designed protein shows a thermally induced transition from a native to a molten globule-like state Journal of the American Chemical Society. 114: 10079-10081. DOI: 10.1021/Ja00051A061  0.548
1992 Akerfeldt KS, Kim RM, Camac D, Groves JT, Lear JD, DeGrado WF. Tetraphilin: a four-helix proton channel built on a tetraphenylporphyrin framework Journal of the American Chemical Society. 114: 9656-9657. DOI: 10.1021/Ja00050A054  0.665
1992 Fairman R, Anthony-Cahill SJ, DeGrado WF. The helix-forming propensity of D-alanine in a right-handed α-helix Journal of the American Chemical Society. 114: 5458-5459. DOI: 10.1021/Ja00039A086  0.773
1992 Osterhout JJ, Handel T, Na G, Toumadje A, Long RC, Connolly PJ, Hoch JC, Johnson WC, Live D, DeGrado WF. Characterization of the structural properties of .alpha.1B, a peptide designed to form a four-helix bundle Journal of the American Chemical Society. 114: 331-337. DOI: 10.1021/Ja00027A043  0.625
1991 DeGrado WF, Raleigh DP, Handel T. De novo protein design: what are we learning? Current Opinion in Structural Biology. 1: 984-993. DOI: 10.1016/0959-440X(91)90095-B  0.574
1990 Hill CP, Anderson DH, Wesson L, DeGrado WF, Eisenberg D. Crystal structure of alpha 1: implications for protein design. Science (New York, N.Y.). 249: 543-6. PMID 2382133 DOI: 10.1126/Science.2382133  0.421
1990 DeGrado WF, Lear JD. Conformationally constrained α-helical peptide models for protein ion channels Biopolymers. 29: 205-213. PMID 1691664 DOI: 10.1002/Bip.360290125  0.407
1990 Handel T, DeGrado WF. De novo design of a Zn2+-binding protein Journal of the American Chemical Society. 112: 6710-6711. DOI: 10.1021/Ja00174A039  0.606
1989 Degrado WF, May SW. Emil Thomas Kaiser 1938-1988 Journal of Molecular Recognition : Jmr. 1: i-ii. PMID 2698723 DOI: 10.1002/jmr.300010408  0.442
1988 Eisenberg D, Wilcox W, Eshita SM, Pryciak PM, Ho SP, DeGrado WF. The design, synthesis, and crystallization of an alpha-helical peptide. Proteins. 1: 16-22. PMID 3449847 DOI: 10.1002/Prot.340010105  0.403
1988 Regan L, DeGrado WF. Characterization of a helical protein designed from first principles. Science (New York, N.Y.). 241: 976-8. PMID 3043666 DOI: 10.1126/Science.3043666  0.627
1987 DeGrado WF, Regan L, Ho SP. The design of a four-helix bundle protein. Cold Spring Harbor Symposia On Quantitative Biology. 52: 521-6. PMID 3454275 DOI: 10.1101/Sqb.1987.052.01.059  0.617
1985 Briggs MS, Gierasch LM, Zlotnick A, Lear JD, DeGrado WF. In vivo function and membrane binding properties are correlated for Escherichia coli LamB signal peptides Science. 228: 1096-1099. PMID 3158076 DOI: 10.1126/Science.3158076  0.402
1983 DEGRADO WF, KAISER ET. ChemInform Abstract: SOLID-PHASE SYNTHESIS OF PROTECTED PEPTIDES ON A POLYMER-BOUND OXIME: PREPARATION OF SEGMENTS COMPRISING THE SEQUENCE OF A CYTOTOXIC 26-PEPTIDE ANALOG Chemischer Informationsdienst. 14. DOI: 10.1002/chin.198303338  0.501
1982 DeGrado WF, Musso GF, Lieber M, Kaiser ET, Kézdy FJ. Kinetics and mechanism of hemolysis induced by melittin and by a synthetic melittin analogue. Biophysical Journal. 37: 329-38. PMID 7055625 DOI: 10.1016/S0006-3495(82)84681-X  0.593
1981 DeGrado WF, Kezdy FJ, Kaiser ET. Design, synthesis, and characterization of a cytotoxic peptide with melittin-like activity Journal of the American Chemical Society. 103: 679-681. DOI: 10.1021/ja00393a035  0.527
1981 DeGrado WF, Kézdy FJ, Kaiser ET. Design, synthesis and characterization of a cytotoxic peptide with melittin-like activity Journal of the American Chemical Society. 103: 679-681. DOI: 10.1021/Ja00393A035  0.579
1981 DEGRADO WF, KEZDY FJ, KAISER ET. ChemInform Abstract: DESIGN, SYNTHESIS, AND CHARACTERIZATION OF A CYTOTOXIC PEPTIDE WITH MELITTIN-LIKE ACTIVITY Chemischer Informationsdienst. 12. DOI: 10.1002/chin.198121334  0.526
1980 DeGrado WF, Kaiser ET. Polymer-bound oxime esters as supports for solid-phase peptide synthesis. The preparation of protected peptide fragments The Journal of Organic Chemistry. 45: 1295-1300. DOI: 10.1021/jo01295a026  0.494
1980 Degrado WF, Kaiser ET. Polymer-bound oxime esters as supports for solid-phase peptide synthesis. Preparation of protected peptide fragments Journal of Organic Chemistry. 45: 1295-1300. DOI: 10.1021/Jo01295A026  0.55
1980 Bramson HN, Thomas N, DeGrado WF, Kaiser ET. Development of a convenient spectrophotometric assay for peptide phosphorylation catalyzed by adenosine 3',5'-monophosphate dependent protein kinase Journal of the American Chemical Society. 102: 7156-7157. DOI: 10.1021/ja00543a068  0.493
1980 DEGRADO WF, KAISER ET. ChemInform Abstract: POLYMER-BOUND OXIME ESTERS AS SUPPORTS FOR SOLID-PHASE PEPTIDE SYNTHESIS. THE PREPARATION OF PROTECTED PEPTIDE FRAGMENTS Chemischer Informationsdienst. 11. DOI: 10.1002/chin.198029331  0.494
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